Pub Date : 2023-03-29DOI: 10.51523/2708-6011.2023-20-1-17
I. Novikova, A. A. Romaniva, A. Salivonchik, S. Khoduleva, S. S. Prokopovich
The article presents a clinical case of a rare primary immunodeficiency syndrome Hyperimmunoglobulinemia E. Typical clinical symptoms, diagnostic and treatment tactics have been demonstrated.
{"title":"Hyperimmunoglobulin E syndrome","authors":"I. Novikova, A. A. Romaniva, A. Salivonchik, S. Khoduleva, S. S. Prokopovich","doi":"10.51523/2708-6011.2023-20-1-17","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-17","url":null,"abstract":"The article presents a clinical case of a rare primary immunodeficiency syndrome Hyperimmunoglobulinemia E. Typical clinical symptoms, diagnostic and treatment tactics have been demonstrated.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125383444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-29DOI: 10.51523/2708-6011.2023-20-1-18
A. V. Voropaeva, A. Borsuk, N. Shevchenko, S. .. Martynenko
Objective. To study primary resistance of H. pylori to clarithromycin in residents of Gomel region by real-time polymerase chain reaction (PCR RT) using TaqMan® MGB probes.Materials and methods. The study included 184 patients diagnosed with gastritis and duodenitis, K29, median age 48.5 years (25% and 75% were 37 and 61 years old). According to the patients’ questionnaires, no clarithromycin-based eradication therapy was administered. To determine the resistance of H. pylori to clarithromycin, a PCR RV method using TagMan® MGB probes was used.Results. All 184 tested DNA samples were positive for the Rnase P gene (ICS) and were considered in further analysis (Ct, HEX 20.20-34.14). DNA from the cagH gene (Ct, FAM 21.26-33.04), indicating infection with the bacterium, was confirmed in 152 samples (82.6%). DNA from the 23SrRNA gene (point mutations A2142G and A2143G) was detected in 16 of 152 DNA samples 10.5 % (Ct, Hex 20.24-31.17). The positive control samples had characteristic curve growth in the corresponding detection channels; no curve growth was observed in the negative samples.Conclusion. The primary resistance of H. pylori to clarithromycin in the residents of Gomel region was 10.5%, and the use of triple first-line eradication therapy, including PPIs, amoxicillin and clarithromycin, as empirical in this region is consistent with the Maastricht III-VI recommendations and Decree of the Ministry of Health of the Republic of Belarus of 01.06.2017 № 54: clinical protocol “Diagnosis and treatment of patients with digestive diseases.” The use of PCR RT using TaqMan® MGB probes is justified to determine the resistance of H. pylori to clarithromycin, to prescribe individualized treatment and to evaluate the effectiveness of eradication regimens.
{"title":"Determination of Helicobacter pylori resistance to clarithromycin in biopsy samples of gastric mucosa using TaqMan® MGB probes","authors":"A. V. Voropaeva, A. Borsuk, N. Shevchenko, S. .. Martynenko","doi":"10.51523/2708-6011.2023-20-1-18","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-18","url":null,"abstract":"Objective. To study primary resistance of H. pylori to clarithromycin in residents of Gomel region by real-time polymerase chain reaction (PCR RT) using TaqMan® MGB probes.Materials and methods. The study included 184 patients diagnosed with gastritis and duodenitis, K29, median age 48.5 years (25% and 75% were 37 and 61 years old). According to the patients’ questionnaires, no clarithromycin-based eradication therapy was administered. To determine the resistance of H. pylori to clarithromycin, a PCR RV method using TagMan® MGB probes was used.Results. All 184 tested DNA samples were positive for the Rnase P gene (ICS) and were considered in further analysis (Ct, HEX 20.20-34.14). DNA from the cagH gene (Ct, FAM 21.26-33.04), indicating infection with the bacterium, was confirmed in 152 samples (82.6%). DNA from the 23SrRNA gene (point mutations A2142G and A2143G) was detected in 16 of 152 DNA samples 10.5 % (Ct, Hex 20.24-31.17). The positive control samples had characteristic curve growth in the corresponding detection channels; no curve growth was observed in the negative samples.Conclusion. The primary resistance of H. pylori to clarithromycin in the residents of Gomel region was 10.5%, and the use of triple first-line eradication therapy, including PPIs, amoxicillin and clarithromycin, as empirical in this region is consistent with the Maastricht III-VI recommendations and Decree of the Ministry of Health of the Republic of Belarus of 01.06.2017 № 54: clinical protocol “Diagnosis and treatment of patients with digestive diseases.” The use of PCR RT using TaqMan® MGB probes is justified to determine the resistance of H. pylori to clarithromycin, to prescribe individualized treatment and to evaluate the effectiveness of eradication regimens.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133297178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-29DOI: 10.51523/2708-6011.2023-20-1-12
A. Yurkovskiy, E. I. Pismennikova, S. L. Achinovich
Objective. To study the possibility of using ultrasonography to identify mild (early), moderately severe and significantly severe dystrophic changes in the sciatic nerve.Materials and methods. To achieve this goal, we compared ultrasonographic and histological data from 15 pairs of sciatic nerves taken from 8 men and 7 women aged 58 (52; 68) years who had been treated for different oncological diseases and died in 2022 from the underlying disease.Results. Parallelism was revealed between the ultrasonographic pattern in mild, moderately severe and significantly severe dystrophic changes of the sciatic nerve, on the one hand, and the histological and immunohistochemical patterns, on the other hand.Conclusion: Ultrasonography (B-mode) allows identifying mild, moderately severe and significantly severe dystrophic changes of the sciatic nerve.
{"title":"Dystrophic changes in the sciatic nerve: a comparison of ultrasonographic and morphological data (pilot study)","authors":"A. Yurkovskiy, E. I. Pismennikova, S. L. Achinovich","doi":"10.51523/2708-6011.2023-20-1-12","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-12","url":null,"abstract":"Objective. To study the possibility of using ultrasonography to identify mild (early), moderately severe and significantly severe dystrophic changes in the sciatic nerve.Materials and methods. To achieve this goal, we compared ultrasonographic and histological data from 15 pairs of sciatic nerves taken from 8 men and 7 women aged 58 (52; 68) years who had been treated for different oncological diseases and died in 2022 from the underlying disease.Results. Parallelism was revealed between the ultrasonographic pattern in mild, moderately severe and significantly severe dystrophic changes of the sciatic nerve, on the one hand, and the histological and immunohistochemical patterns, on the other hand.Conclusion: Ultrasonography (B-mode) allows identifying mild, moderately severe and significantly severe dystrophic changes of the sciatic nerve.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117211617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-29DOI: 10.51523/2708-6011.2023-20-1-19
A. Shaforost, A. A. Ziatskov, E. Voropaev, O. Osipkina, A. V. Voropaeva, N. Bonda, I. Stoma
Objective. To review the main stages of Klebsiella pneumoniae genome sequencing using the Illumina short-read method and describe the peculiarities of sample library preparation and analysis of the obtained data.Materials and methods. Deoxyribonucleic acid (DNA) for high-throughput sequencing was isolated from Klebsiella pneumoniae cultures. Sample preparation was performed according to the manufacturer’s instructions for the Nextera XT DNA Library Prep kit. Sequencing was performed on an Illumina MiSeq platform using a 2x151 cartridge. Genome assembly to the contigs was performed using the SPAdes Genome Assembler application on the Illumina BaseSpace Sequence Hub service and a set of programs in a Linux environment. The quality of genome assembly was assessed using the QUAST service.Results. Genome sequencing of K. pneumoniae culture samples was performed, followed by an evaluation of the quality of the launch, assembly of the genome, and determination of its main parameters.Conclusion. The main steps of K. pneumoniae genome sequencing have been considered using the short-read method on the Illumina platform. The main parameters for assessing the quality of sample preparation, launch and genome assembly are described.
{"title":"Experience of Klebsiella pneumoniae genome sequencing using the short read method on the Illumina platform","authors":"A. Shaforost, A. A. Ziatskov, E. Voropaev, O. Osipkina, A. V. Voropaeva, N. Bonda, I. Stoma","doi":"10.51523/2708-6011.2023-20-1-19","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-19","url":null,"abstract":"Objective. To review the main stages of Klebsiella pneumoniae genome sequencing using the Illumina short-read method and describe the peculiarities of sample library preparation and analysis of the obtained data.Materials and methods. Deoxyribonucleic acid (DNA) for high-throughput sequencing was isolated from Klebsiella pneumoniae cultures. Sample preparation was performed according to the manufacturer’s instructions for the Nextera XT DNA Library Prep kit. Sequencing was performed on an Illumina MiSeq platform using a 2x151 cartridge. Genome assembly to the contigs was performed using the SPAdes Genome Assembler application on the Illumina BaseSpace Sequence Hub service and a set of programs in a Linux environment. The quality of genome assembly was assessed using the QUAST service.Results. Genome sequencing of K. pneumoniae culture samples was performed, followed by an evaluation of the quality of the launch, assembly of the genome, and determination of its main parameters.Conclusion. The main steps of K. pneumoniae genome sequencing have been considered using the short-read method on the Illumina platform. The main parameters for assessing the quality of sample preparation, launch and genome assembly are described.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132291994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-02
E. G. Malaeva, L. P. Zaitseva, A. S. Knyazyuk, O. Osipkina
Objective. To determine the possibilities of cytological method of urine cellular sediment examination for diagnosis and differential diagnosis of renal and urinary tract pathology in liver cirrhosis.Materials and methods. A standard observational study of 50 inpatients with liver cirrhosis was performed. Cytological preparations of urine sediment were prepared by liquid cytology and cytocentrifugation methods and after fixation were Results. Cytological study of cellular urine sediment in hospitalized patients with cirrhosis revealed dysmorphic (leached) erythrocytes in 31% of cases, statistically significantly more frequently in patients with decompensation of the disease and 30-day mortality (p<0,05). Microflora in the urine was found in 63% of patients, more often of mixed nature (27%). In 46% of patients with decompensated liver cirrhosis, including acute renal injury, cytological preparation of urinary sediment is represented by multicellular elements with the presence of superficial and deep urothelium and renal epithelium.Conclusions. Cytological method of studying the cellular urine sediment is an accessible, informative and cheap diagnostic method, the possibilities of which are to determine the presence and origin of cellular elements (urothelium of the surface and deep layers, altered erythrocytes), microflora and its source (genital tract, urinary tract), which, in combination with other methods, allows to verify the diagnosis of the patient and to carry out differential diagnosis of acute tubular necrosis and hepatorenal syndrome.
{"title":"Cytological method of research in the diagnosis of urinary pathology in liver cirrhosis","authors":"E. G. Malaeva, L. P. Zaitseva, A. S. Knyazyuk, O. Osipkina","doi":"10.51523/2708-6011.2023-20-1-02","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-02","url":null,"abstract":"Objective. To determine the possibilities of cytological method of urine cellular sediment examination for diagnosis and differential diagnosis of renal and urinary tract pathology in liver cirrhosis.Materials and methods. A standard observational study of 50 inpatients with liver cirrhosis was performed. Cytological preparations of urine sediment were prepared by liquid cytology and cytocentrifugation methods and after fixation were Results. Cytological study of cellular urine sediment in hospitalized patients with cirrhosis revealed dysmorphic (leached) erythrocytes in 31% of cases, statistically significantly more frequently in patients with decompensation of the disease and 30-day mortality (p<0,05). Microflora in the urine was found in 63% of patients, more often of mixed nature (27%). In 46% of patients with decompensated liver cirrhosis, including acute renal injury, cytological preparation of urinary sediment is represented by multicellular elements with the presence of superficial and deep urothelium and renal epithelium.Conclusions. Cytological method of studying the cellular urine sediment is an accessible, informative and cheap diagnostic method, the possibilities of which are to determine the presence and origin of cellular elements (urothelium of the surface and deep layers, altered erythrocytes), microflora and its source (genital tract, urinary tract), which, in combination with other methods, allows to verify the diagnosis of the patient and to carry out differential diagnosis of acute tubular necrosis and hepatorenal syndrome.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122307113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-04
G. E. Litvinov, V. Smychek, N. Halinouskaya, N. A. Evseenko, A. V. Lapin
Objective. To evaluate the effectiveness of extremely high frequency (EHF) millimeter range electromagnetic radiation (EMR) of low intensity in patients with malignant neoplasms suffering from chronic pain syndrome (CPS).Materials and methods. The study included 60 patients with diagnosed malignant neoplasm (MN) who were treated in a palliative care unit. They were divided into 2 groups. The main group consisted of 30 patients who underwent additional EHF-exposure with a course of 10 sessions of 15 minutes simultaneously with the main therapeutic measures. The comparison group consisted of patients who did not undergo electromagnetic exposure 30 people. Questioning was conducted twice: on the 2nd and 14th days of treatment. Treatment efficiency was assessed using standardized questionnaires.Results. The analgesic effect of additional use of EHF therapy with a fixed frequency of 53.534 ± 0.015 GHz in patients with MN was significantly higher than the analgesic effect of standard treatment. In particular, there was an increase in mobility, as well as a decrease in depression and reactive anxiety.Conclusion. The additional use of EHF therapy in patients with MN provides the advantage of improving quality of life by reducing CPS, improving psychological well-being and improving the ability to move independently.
{"title":"The effectiveness of EHF therapy in patients with malignant neoplasms suffering from chronic pain syndrome","authors":"G. E. Litvinov, V. Smychek, N. Halinouskaya, N. A. Evseenko, A. V. Lapin","doi":"10.51523/2708-6011.2023-20-1-04","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-04","url":null,"abstract":"Objective. To evaluate the effectiveness of extremely high frequency (EHF) millimeter range electromagnetic radiation (EMR) of low intensity in patients with malignant neoplasms suffering from chronic pain syndrome (CPS).Materials and methods. The study included 60 patients with diagnosed malignant neoplasm (MN) who were treated in a palliative care unit. They were divided into 2 groups. The main group consisted of 30 patients who underwent additional EHF-exposure with a course of 10 sessions of 15 minutes simultaneously with the main therapeutic measures. The comparison group consisted of patients who did not undergo electromagnetic exposure 30 people. Questioning was conducted twice: on the 2nd and 14th days of treatment. Treatment efficiency was assessed using standardized questionnaires.Results. The analgesic effect of additional use of EHF therapy with a fixed frequency of 53.534 ± 0.015 GHz in patients with MN was significantly higher than the analgesic effect of standard treatment. In particular, there was an increase in mobility, as well as a decrease in depression and reactive anxiety.Conclusion. The additional use of EHF therapy in patients with MN provides the advantage of improving quality of life by reducing CPS, improving psychological well-being and improving the ability to move independently.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121406002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-05
L. V. Kastsova
Objective. To develop a method for determining the risk of reproductive loss in the 1st trimester of pregnancy.Materials and methods. Blood serum, whole blood, medical records of an inpatient (form No. 003/-07), and exchange cards (form No. 113/-07) of 94 pregnant women. Interleukin-6 concentration was assessed in the examined patients by immune-enzyme analysis. The level of leukocytes and monocytes was determined in whole blood by general clinical routine methods on a hematology analyzer. Statistica 10.0 software package and “R” programming language, version 4.1, were used for statistical analysis.Results. The developed logistic regression equation (sensitivity, 87.5%; specificity, 83.33%; classification accuracy, 86.17%) by determining the linear predictor Z makes it possible to assign a pregnant woman to the high risk group for the development of reproductive loss in the 1st trimester (Z > -0.4519).Conclusion. The proposed new method for determining a high risk of developing reproductive loss in the 1st trimester of pregnancy makes it possible to carry out appropriate therapeutic measures to help preserve women’s reproductive health, improve fertility, and increase the birth rate.
{"title":"Method for determining the risk of developing reproductive loss in the 1st trimester of pregnancy","authors":"L. V. Kastsova","doi":"10.51523/2708-6011.2023-20-1-05","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-05","url":null,"abstract":"Objective. To develop a method for determining the risk of reproductive loss in the 1st trimester of pregnancy.Materials and methods. Blood serum, whole blood, medical records of an inpatient (form No. 003/-07), and exchange cards (form No. 113/-07) of 94 pregnant women. Interleukin-6 concentration was assessed in the examined patients by immune-enzyme analysis. The level of leukocytes and monocytes was determined in whole blood by general clinical routine methods on a hematology analyzer. Statistica 10.0 software package and “R” programming language, version 4.1, were used for statistical analysis.Results. The developed logistic regression equation (sensitivity, 87.5%; specificity, 83.33%; classification accuracy, 86.17%) by determining the linear predictor Z makes it possible to assign a pregnant woman to the high risk group for the development of reproductive loss in the 1st trimester (Z > -0.4519).Conclusion. The proposed new method for determining a high risk of developing reproductive loss in the 1st trimester of pregnancy makes it possible to carry out appropriate therapeutic measures to help preserve women’s reproductive health, improve fertility, and increase the birth rate.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126120507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-08
I. D. Shlyaga, M. O. Miazheinikava, N. P. Cheliabiyeva, I. P. Hlavatskaya, I. F. Shalyga
Objective. To analyze the incidence of lymphoid structures of the pharynx among the adult population during the period from January 2021 to August 2022 in three nosological forms: chronic decompensated tonsillitis (CDT), hypertrophy of pharyngeal tonsils (HPT), hypertrophy of lingual tonsillitis (HLT). To determine the relationship of the above pathology between the age and sex of patients at the present stage. To evaluate the role of mycobiota in the structure of pharyngeal morbidity.Materials and methods. The object of the study was 96 patients with chronic pathology of the lymphoid structures of the pharynx aged from 17 to 70 years, who were on inpatient treatment at the Gomel Regional Clinical Hospital (GRCH) during the period from January 2021 to August 2022. All patients underwent surgical intervention followed by an assessment of the pathohistological conclusions of postoperative samples of pharyngeal lymphatic formations. The patients were divided into 3 nosological study groups: CDT; HPT; HLT. Statistical data processing was performed using software: MS Excel and the programming language for statistical data analysis R (version 4.2.1), packages tidyverse (version 1.3.1), rstatix (version 0.7.0), ggstatsplot (version 0.9.5).Results. The study revealed the most common nosological groups among patients with pathology of the pharyngeal lymphatic ring of Pirogov-Waldeyer: CDT (44%) and HPT (38%). A significant difference was revealed between the incidence rates of pathology of the Pirogov-Waldeyer pharyngeal lymphatic ring in the study age groups from 17 to 25 years (p=0.0008); from 26 to 35 years (p=0.0021); 56 years and older (p=0.008). The median age of patients in the study group was 35 years (LQ 24.0; UQ 48.5), whereas in some nosological forms: CDT – 30 years (LQ 23.0; UQ 41.0), namely 28 years among women and 36 years among men; HРT – 32.5 years (LQ 24.0; UQ 43.25), namely 34.5 years among women and 31.5 years among men; HLT – 57 years (LQ 49.0; UQ 63.0), and it is 56.5 years among women and 57 years among men. Morphological examination revealed only 2 (2%) cases of mycotic lesions of the removed lymphoid masses.Conclusion. The relationship between the pathology of lymphoid structures of the pharynx in three nosological forms (CDT, HPT, HLT) and the age of patients was revealed. The role of mycobiota in the overall study group in the structure of pharyngeal morbidity at the present stage was evaluated.
{"title":"Analysis of chronic pathology of the pharynx according to the results of pathohistological findings","authors":"I. D. Shlyaga, M. O. Miazheinikava, N. P. Cheliabiyeva, I. P. Hlavatskaya, I. F. Shalyga","doi":"10.51523/2708-6011.2023-20-1-08","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-08","url":null,"abstract":"Objective. To analyze the incidence of lymphoid structures of the pharynx among the adult population during the period from January 2021 to August 2022 in three nosological forms: chronic decompensated tonsillitis (CDT), hypertrophy of pharyngeal tonsils (HPT), hypertrophy of lingual tonsillitis (HLT). To determine the relationship of the above pathology between the age and sex of patients at the present stage. To evaluate the role of mycobiota in the structure of pharyngeal morbidity.Materials and methods. The object of the study was 96 patients with chronic pathology of the lymphoid structures of the pharynx aged from 17 to 70 years, who were on inpatient treatment at the Gomel Regional Clinical Hospital (GRCH) during the period from January 2021 to August 2022. All patients underwent surgical intervention followed by an assessment of the pathohistological conclusions of postoperative samples of pharyngeal lymphatic formations. The patients were divided into 3 nosological study groups: CDT; HPT; HLT. Statistical data processing was performed using software: MS Excel and the programming language for statistical data analysis R (version 4.2.1), packages tidyverse (version 1.3.1), rstatix (version 0.7.0), ggstatsplot (version 0.9.5).Results. The study revealed the most common nosological groups among patients with pathology of the pharyngeal lymphatic ring of Pirogov-Waldeyer: CDT (44%) and HPT (38%). A significant difference was revealed between the incidence rates of pathology of the Pirogov-Waldeyer pharyngeal lymphatic ring in the study age groups from 17 to 25 years (p=0.0008); from 26 to 35 years (p=0.0021); 56 years and older (p=0.008). The median age of patients in the study group was 35 years (LQ 24.0; UQ 48.5), whereas in some nosological forms: CDT – 30 years (LQ 23.0; UQ 41.0), namely 28 years among women and 36 years among men; HРT – 32.5 years (LQ 24.0; UQ 43.25), namely 34.5 years among women and 31.5 years among men; HLT – 57 years (LQ 49.0; UQ 63.0), and it is 56.5 years among women and 57 years among men. Morphological examination revealed only 2 (2%) cases of mycotic lesions of the removed lymphoid masses.Conclusion. The relationship between the pathology of lymphoid structures of the pharynx in three nosological forms (CDT, HPT, HLT) and the age of patients was revealed. The role of mycobiota in the overall study group in the structure of pharyngeal morbidity at the present stage was evaluated.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116920331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-07
L. A. Cherniak, P. V. Harelik, M. V. Haretskaya, V. Sheibak
Objective. To study the effect of local photodynamic therapy (PDT) on local immunity in patients with maxillofacial region and neck phlegmonas.Materials and methods. The study included 62 patients with phlegmon of the maxillofacial region and neck. Two groups of patients were formed. Patients of the 1st group were treated locally according to the traditional methods. Patients of the second group additionally underwent local PDT on the background of the complex of traditional therapeutic measures.Results. Under the influence of local PDT with the preparation «Fotolon» in patients with maxillofacial region phlegmonomas in the postoperative wound we observed activation of phagocytosis, an increase in the population of CD3 + T-lymphocytes, subpopulation CD4 + T-helper, immunoregulatory index (IRI) with a simultaneous decrease in the level of CD8 + T-lymphocytes, The decrease of CD25+ activated Tand B-lymphocytes carrying the receptor for interleukin 2, and CD95+ activated Tand B-lymphocytes carrying the Fas-receptor, the decrease of complement activity, circulating immune complexes (CIC), IgM, IgA levels with an increase of IgG.Conclusion. Local PDT activates local immunity in patients with maxillofacial and neck phlegmons. Exposure to PDT causes a more balanced immune system response by increasing the innate immune response in patients and a pronounced immunological reactivity in the region of the postoperative wound.
{"title":"State of local immune in phegmon of the maxillofacial region and neck on the background local photodynamic therapy","authors":"L. A. Cherniak, P. V. Harelik, M. V. Haretskaya, V. Sheibak","doi":"10.51523/2708-6011.2023-20-1-07","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-07","url":null,"abstract":"Objective. To study the effect of local photodynamic therapy (PDT) on local immunity in patients with maxillofacial region and neck phlegmonas.Materials and methods. The study included 62 patients with phlegmon of the maxillofacial region and neck. Two groups of patients were formed. Patients of the 1st group were treated locally according to the traditional methods. Patients of the second group additionally underwent local PDT on the background of the complex of traditional therapeutic measures.Results. Under the influence of local PDT with the preparation «Fotolon» in patients with maxillofacial region phlegmonomas in the postoperative wound we observed activation of phagocytosis, an increase in the population of CD3 + T-lymphocytes, subpopulation CD4 + T-helper, immunoregulatory index (IRI) with a simultaneous decrease in the level of CD8 + T-lymphocytes, The decrease of CD25+ activated Tand B-lymphocytes carrying the receptor for interleukin 2, and CD95+ activated Tand B-lymphocytes carrying the Fas-receptor, the decrease of complement activity, circulating immune complexes (CIC), IgM, IgA levels with an increase of IgG.Conclusion. Local PDT activates local immunity in patients with maxillofacial and neck phlegmons. Exposure to PDT causes a more balanced immune system response by increasing the innate immune response in patients and a pronounced immunological reactivity in the region of the postoperative wound.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122528519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-10
A. V. Kuzmenko, V. N. Zhdanovich
Objectives. To explore data on branching variants of the intrapelvic part of the superior gluteal artery in people of mesomorphic somatotype.Materials and methods. We used 48 male dead bodies (deceased aged 25 to 82) and 30 female dead bodies (deceased aged 28 to 78) whose deaths were the result of accidental causes unrelated to the pelvic organs pathology. The following methods were used to achieve the goal of the study: vascular injection, dissection, statistical processing.Results. The pattern of localization of anastomotic branches of the intrapelvic part of the superior gluteal artery (SGA) in humans of both sexes of mesomorphic somatotype was established for the first time. In men, 59.1% of all anastomotic branches of the SGA are located in the proximal third, 36.4% of anastomoses are in the middle third of this artery, and 4.5% of arterial connections are in the distal third of a. glutea superior. In women, arterial anastomoses branch from the proximal third of the intrapelvic portion of the SGA in 66.6% of cases and in the middle third of this artery in 33.3% of cases. The SGA in men of mesomorphic somatotype anastomoses more frequently than in women with the same type of build. It was found that intrathecal branches and anastomoses of the SGA in men and women of mesomorphic somatotype are predominantly localized along the proximal two thirds of this artery length. New data were obtained on the number of branches originating from a. glutea superior in the pelvic cavity, such as the lateral sacral artery (LSA), iliac-lumbar artery (ILA), obturator artery (OA), middle rectus, lower ureteric artery and rami musculares of the SGA. The SGA was found to be the most frequent source of lateral sacral artery formation in the pelvic cavity in men and women of mesomorphic somatotype.Conclusions. The patterns of branching of the intrathecal part of the SGA are presented. The results obtained are recommended to be used for endovascular occlusion of the SGA to stop bleeding from the damaged distal third of this artery.
{"title":"Surgical anatomy of the intrapelvic branches of the superior gluteal artery in people of a mesohomorphic somatotype","authors":"A. V. Kuzmenko, V. N. Zhdanovich","doi":"10.51523/2708-6011.2023-20-1-10","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-10","url":null,"abstract":"Objectives. To explore data on branching variants of the intrapelvic part of the superior gluteal artery in people of mesomorphic somatotype.Materials and methods. We used 48 male dead bodies (deceased aged 25 to 82) and 30 female dead bodies (deceased aged 28 to 78) whose deaths were the result of accidental causes unrelated to the pelvic organs pathology. The following methods were used to achieve the goal of the study: vascular injection, dissection, statistical processing.Results. The pattern of localization of anastomotic branches of the intrapelvic part of the superior gluteal artery (SGA) in humans of both sexes of mesomorphic somatotype was established for the first time. In men, 59.1% of all anastomotic branches of the SGA are located in the proximal third, 36.4% of anastomoses are in the middle third of this artery, and 4.5% of arterial connections are in the distal third of a. glutea superior. In women, arterial anastomoses branch from the proximal third of the intrapelvic portion of the SGA in 66.6% of cases and in the middle third of this artery in 33.3% of cases. The SGA in men of mesomorphic somatotype anastomoses more frequently than in women with the same type of build. It was found that intrathecal branches and anastomoses of the SGA in men and women of mesomorphic somatotype are predominantly localized along the proximal two thirds of this artery length. New data were obtained on the number of branches originating from a. glutea superior in the pelvic cavity, such as the lateral sacral artery (LSA), iliac-lumbar artery (ILA), obturator artery (OA), middle rectus, lower ureteric artery and rami musculares of the SGA. The SGA was found to be the most frequent source of lateral sacral artery formation in the pelvic cavity in men and women of mesomorphic somatotype.Conclusions. The patterns of branching of the intrathecal part of the SGA are presented. The results obtained are recommended to be used for endovascular occlusion of the SGA to stop bleeding from the damaged distal third of this artery.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"264 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116395087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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