Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-01
N. Bonda, I. Stoma, O. Osipkina, A. A. Ziatskov, A. Shaforost, E. V. Karpova, D. Tapalski
Objective. To evaluate genetic mechanisms of antibiotic resistance and virulence of invasive strains of Klebsiella pneumoniae isolated from inpatients using whole genome sequencing.Materials and methods. For two carbapenem-resistant multiple-antibiotic-resistant invasive strains of K.pneumoniae, as well as two carbapenem-sensitive invasive strains of K.pneumoniae, sequencing was performed using the MiSeq genomic sequencer (Illumina). Genomic sequences were assembled and annotated. Sequence type determination, search for plasmids and virulence factors, antibiotic resistance genes, and efflux mechanisms were performed.Results. K.pneumoniae strains belonged to sequence types ST395, ST101, ST111, and ST512 s and had a hypermucoid phenotype. The iutA aerobactin genes were detected in both sensitive and carbapenem-resistant strains. Virulence genes fimH, fyuA, and irp2 were detected in one strain isolated from blood. Carbapenemase genes (blaKPC, blaNDM) were detected in two strains. Aminoglycosides and fluoroquinolones resistance genes were detected in 3 of 4 strains. All strains showed the presence of different systems of active antibiotic elimination from the microbial cell.Conclusion. The possibility of identifying hypervirulent strains of K.pneumoniae using a complex phenotypic test along with hvKp genotyping is shown. The results of full-genome sequencing reflect significant resistance of hypervirulent K.pneumoniae strains isolated from blood to most antibiotics, including β-lactams, aminoglycosides, fluoroquinolones, phosphomycin, chloramphenicol and polymyxins.
{"title":"Molecular genetic markers of resistance and virulence of invasive Klebsiella pneumoniae strains according to whole genome sequencing data","authors":"N. Bonda, I. Stoma, O. Osipkina, A. A. Ziatskov, A. Shaforost, E. V. Karpova, D. Tapalski","doi":"10.51523/2708-6011.2023-20-1-01","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-01","url":null,"abstract":"Objective. To evaluate genetic mechanisms of antibiotic resistance and virulence of invasive strains of Klebsiella pneumoniae isolated from inpatients using whole genome sequencing.Materials and methods. For two carbapenem-resistant multiple-antibiotic-resistant invasive strains of K.pneumoniae, as well as two carbapenem-sensitive invasive strains of K.pneumoniae, sequencing was performed using the MiSeq genomic sequencer (Illumina). Genomic sequences were assembled and annotated. Sequence type determination, search for plasmids and virulence factors, antibiotic resistance genes, and efflux mechanisms were performed.Results. K.pneumoniae strains belonged to sequence types ST395, ST101, ST111, and ST512 s and had a hypermucoid phenotype. The iutA aerobactin genes were detected in both sensitive and carbapenem-resistant strains. Virulence genes fimH, fyuA, and irp2 were detected in one strain isolated from blood. Carbapenemase genes (blaKPC, blaNDM) were detected in two strains. Aminoglycosides and fluoroquinolones resistance genes were detected in 3 of 4 strains. All strains showed the presence of different systems of active antibiotic elimination from the microbial cell.Conclusion. The possibility of identifying hypervirulent strains of K.pneumoniae using a complex phenotypic test along with hvKp genotyping is shown. The results of full-genome sequencing reflect significant resistance of hypervirulent K.pneumoniae strains isolated from blood to most antibiotics, including β-lactams, aminoglycosides, fluoroquinolones, phosphomycin, chloramphenicol and polymyxins.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131629814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-09
V. V. Ponomarev, E. V. Reduto
Objective. To study the correlation between the neurological, immunological and neurophysiological signs of paraneoplastic polyneuropathy (PPNP) caused by small cell lung cancer (SCLC), to improve the quality of diagnosis of this pathology.Materials and methods. Clinical, immunological (anti-Hu) and neurophysiological (electromyography (EMG), electroneuromyography (ENMG), somatosensory evoked potentials (SSEP)) examination of 61 patients with PPNP caused by SCLC are presented.Results. It was established that sensory disorders in the limbs are the first and obligate clinical symptoms of PPNP, which precede the initial diagnosis of SCLC in 56% in 3-12 months, characterized by a predominance of a decrease in surface sensitivity in the form of distal hypoesthesia in 70% of cases. The motor form is characterized by an older age (67 years) than the sensory (60 years) and sensorimotor (58.0 years, p <0,05). Motor disorders in the limbs occur in 46% of cases, manifested by mild symmetrical distal paresis of the legs and subclinical damage to the motor nerves of the upper extremities according to the results of ENMG (p <0,001). Detection of anti-Hu in plasma is highly correlated with a significant increase in latency and a decrease in amplitudes component N22 in the conduct of SSEP, which indicates the defeat of the axons of the sensory nerves of the limbs (p <0,05). Changes in amplitude parameters, with preserved speed indicators of nerves according to the results of ENMG indicate an axonal type of lesion (p <0,05), which, in combination with the detection of anti-Hu in plasma, are pathognomonic signs of the paraneoplastic nature of the process.Conclusion. As a result of the study, clinical, immunological and neurophysiological features of various forms of PPNP were identified. The obtained correlations make it possible to diagnose the corresponding type of nerve pathology more accurately and in a timely manner and to suspect the development of oncological disease in time. The revealed changes in the indicators of the N22 component of SSEP can serve as a marker of axonal lesion of peripheral nerves, which with high diagnostic efficiency justifies the expediency of inclusion in the protocol of the ENMG study for verification of additional signs characteristic of PPNP.
{"title":"Clinical-immunological and neurophysiological correlations in paraneoplastic polyneuropathy caused by small cell lung cancer","authors":"V. V. Ponomarev, E. V. Reduto","doi":"10.51523/2708-6011.2023-20-1-09","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-09","url":null,"abstract":"Objective. To study the correlation between the neurological, immunological and neurophysiological signs of paraneoplastic polyneuropathy (PPNP) caused by small cell lung cancer (SCLC), to improve the quality of diagnosis of this pathology.Materials and methods. Clinical, immunological (anti-Hu) and neurophysiological (electromyography (EMG), electroneuromyography (ENMG), somatosensory evoked potentials (SSEP)) examination of 61 patients with PPNP caused by SCLC are presented.Results. It was established that sensory disorders in the limbs are the first and obligate clinical symptoms of PPNP, which precede the initial diagnosis of SCLC in 56% in 3-12 months, characterized by a predominance of a decrease in surface sensitivity in the form of distal hypoesthesia in 70% of cases. The motor form is characterized by an older age (67 years) than the sensory (60 years) and sensorimotor (58.0 years, p <0,05). Motor disorders in the limbs occur in 46% of cases, manifested by mild symmetrical distal paresis of the legs and subclinical damage to the motor nerves of the upper extremities according to the results of ENMG (p <0,001). Detection of anti-Hu in plasma is highly correlated with a significant increase in latency and a decrease in amplitudes component N22 in the conduct of SSEP, which indicates the defeat of the axons of the sensory nerves of the limbs (p <0,05). Changes in amplitude parameters, with preserved speed indicators of nerves according to the results of ENMG indicate an axonal type of lesion (p <0,05), which, in combination with the detection of anti-Hu in plasma, are pathognomonic signs of the paraneoplastic nature of the process.Conclusion. As a result of the study, clinical, immunological and neurophysiological features of various forms of PPNP were identified. The obtained correlations make it possible to diagnose the corresponding type of nerve pathology more accurately and in a timely manner and to suspect the development of oncological disease in time. The revealed changes in the indicators of the N22 component of SSEP can serve as a marker of axonal lesion of peripheral nerves, which with high diagnostic efficiency justifies the expediency of inclusion in the protocol of the ENMG study for verification of additional signs characteristic of PPNP.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121157237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-11
D. Evseenko, Z. A. Dundarov, E. Nadyrov
Objective. Develop an experimental model of liver cirrhosis and describe pathomorphological changes in organs and tissues of laboratory animals.Materials and methods. Liver cirrhosis was simulated on 11 sexually mature Wistar male white rats. The control group consisted of 12 healthy laboratory animals. Acute toxic liver injury resulting in cirrhosis was induced by intraperitoneal injection of 50% tetrachloromethane (CCl4) solution on olive oil on the first day of the experiment in the dosage of 0.1 ml CCl4 + 0.4 ml olive oil per 100 g of the animal body weight, on the second day of the experiment 0.3 ml CCl4 + 0.2 ml olive oil per 100 g of the animal body weight. To synergize and potentiate the hepatotoxic effect of CCl4, animals had 10% ethanol solution freely available daily. The duration of the experiment was 65 days. Clinical and laboratory parameters were evaluated, histological evaluation of the preparations was performed. The obtained data were compared with the control group of animals.Results. Reproducibility of the model was 82% (9 animals). The indicator of lymphocyte blabbing index showed the development of liver cirrhosis in animals of the experimental group. Comprehensive morphological confirmation of the developed liver cirrhosis was obtained.Conclusion. The proposed methodology of liver cirrhosis formation correlates with pathomorphological changes in lymphocyte cell wall, changes in liver tissue and internal organs in human liver cirrhosis.
{"title":"Pathomorphological changes in the organs of laboratory animals with experimental liver cirrhosis","authors":"D. Evseenko, Z. A. Dundarov, E. Nadyrov","doi":"10.51523/2708-6011.2023-20-1-11","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-11","url":null,"abstract":"Objective. Develop an experimental model of liver cirrhosis and describe pathomorphological changes in organs and tissues of laboratory animals.Materials and methods. Liver cirrhosis was simulated on 11 sexually mature Wistar male white rats. The control group consisted of 12 healthy laboratory animals. Acute toxic liver injury resulting in cirrhosis was induced by intraperitoneal injection of 50% tetrachloromethane (CCl4) solution on olive oil on the first day of the experiment in the dosage of 0.1 ml CCl4 + 0.4 ml olive oil per 100 g of the animal body weight, on the second day of the experiment 0.3 ml CCl4 + 0.2 ml olive oil per 100 g of the animal body weight. To synergize and potentiate the hepatotoxic effect of CCl4, animals had 10% ethanol solution freely available daily. The duration of the experiment was 65 days. Clinical and laboratory parameters were evaluated, histological evaluation of the preparations was performed. The obtained data were compared with the control group of animals.Results. Reproducibility of the model was 82% (9 animals). The indicator of lymphocyte blabbing index showed the development of liver cirrhosis in animals of the experimental group. Comprehensive morphological confirmation of the developed liver cirrhosis was obtained.Conclusion. The proposed methodology of liver cirrhosis formation correlates with pathomorphological changes in lymphocyte cell wall, changes in liver tissue and internal organs in human liver cirrhosis.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125847468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-03
S. Goponiako
Objective. To study the levels of cytokines (γ-interferon, tumor necrosis factor α (TNF-α)) and hormones (cortisol, prolactin, estradiol, progesterone, testosterone) in blood serum of women of reproductive age with pulmonary tuberculosis (TB).Materials and methods. We studied the serum levels of γ-interferon, tumor necrosis factor α, cortisol, prolactin, estradiol, progesterone, testosterone in women 18-45 years old with newly diagnosed pulmonary TB (n = 47) compared with the same indices in women without TB and with no previous TB (n = 35).Results. Women with pulmonary TB had higher levels of cortisol (cutoff point, 196.1 nmol/L, AUC 0.75, Se 85.1 %, Sp 70.6 %) and prolactin (cutoff point, 486, 1 mEU/L, AUC 0.69, Se 59.6%, Sp 73.5%) and lower serum progesterone levels (cutoff point 3.9 nmol/L, AUC 0.71, Se 73.9%, Sp 64.7%) than women without TB. The study of the levels of γ-interferon and TNF-α showed less diagnostic significance of the parameters, and there was a slight increase in the levels of both cytokines in women with pulmonary TB.Conclusion. Changes in cytokine-hormone status in women with TB can both reflect mechanisms of anti-infective defense and be a consequence of the development of the disease.
目标。目的探讨育龄妇女肺结核(TB)患者血清中细胞因子(γ-干扰素、肿瘤坏死因子α (TNF-α))及激素(皮质醇、催乳素、雌二醇、孕酮、睾酮)水平的变化。材料和方法。我们研究了18-45岁新诊断肺结核妇女(n = 47)的血清γ-干扰素、肿瘤坏死因子α、皮质醇、催乳素、雌二醇、孕酮、睾酮的水平，并将这些指标与未患肺结核和未患肺结核妇女(n = 35)进行了比较。与未患结核病的妇女相比，患有肺结核的妇女皮质醇(临界值，196.1 nmol/L, AUC 0.75, Se 85.1%， Sp 70.6%)和催乳素(临界值，486,1 mEU/L, AUC 0.69, Se 59.6%， Sp 73.5%)水平较高，血清黄体酮水平较低(临界值，3.9 nmol/L, AUC 0.71, Se 73.9%， Sp 64.7%)。研究γ-干扰素和TNF-α水平对诊断意义较低，两种细胞因子水平在女性肺结核患者中均有轻微升高。女性结核病患者细胞因子-激素状态的变化既可以反映抗感染防御机制，也可能是疾病发展的结果。
{"title":"Cytokine and hormone status of women of reproductive age with pulmonary tuberculosis","authors":"S. Goponiako","doi":"10.51523/2708-6011.2023-20-1-03","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-03","url":null,"abstract":"Objective. To study the levels of cytokines (γ-interferon, tumor necrosis factor α (TNF-α)) and hormones (cortisol, prolactin, estradiol, progesterone, testosterone) in blood serum of women of reproductive age with pulmonary tuberculosis (TB).Materials and methods. We studied the serum levels of γ-interferon, tumor necrosis factor α, cortisol, prolactin, estradiol, progesterone, testosterone in women 18-45 years old with newly diagnosed pulmonary TB (n = 47) compared with the same indices in women without TB and with no previous TB (n = 35).Results. Women with pulmonary TB had higher levels of cortisol (cutoff point, 196.1 nmol/L, AUC 0.75, Se 85.1 %, Sp 70.6 %) and prolactin (cutoff point, 486, 1 mEU/L, AUC 0.69, Se 59.6%, Sp 73.5%) and lower serum progesterone levels (cutoff point 3.9 nmol/L, AUC 0.71, Se 73.9%, Sp 64.7%) than women without TB. The study of the levels of γ-interferon and TNF-α showed less diagnostic significance of the parameters, and there was a slight increase in the levels of both cytokines in women with pulmonary TB.Conclusion. Changes in cytokine-hormone status in women with TB can both reflect mechanisms of anti-infective defense and be a consequence of the development of the disease.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134275799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.51523/2708-6011.2023-20-1-06
M. A. Yudenko, I. Buinevich, D. Y. Rusanau
Objective. To study demographic, clinical characteristics and concomitant pathology of patients with extrapulmonary tuberculosis (EPTB) in Gomel city and Gomel region for the period 2017-2021. To evaluate the informative value of different techniques for the detection of Mycobacterium tuberculosis (MBT) in non-respiratory samples in the diagnosis of extrapulmonary tuberculosis.Materials and methods. A retrospective study of extrapulmonary tuberculosis cases registered from 2017 to 2021 in Gomel and Gomel region (308 patients) was carried out. The results of microscopic, bacteriological and molecular genetic methods of non-respiratory and respiratory samples relevant in the diagnosis of extrapulmonary forms of tuberculosis were analyzed.Results. Demographic and clinical characteristics of patients with EPTB in Gomel and Gomel region for the period 20172021 were revealed. Concomitant pathology in patients with EPTB was analyzed, the features of EPTB diagnostics were studied. It was determined that EPTB is more susceptible to males aged 31 to 50 years and to women aged over 60 years. EPTB is more frequently diagnosed in patients from urban areas and when patients come to medical institutions with nonspecific complaints, except for intrathoracic lymph node tuberculosis (ITLN).Conclusion. In the structure of clinical forms of EPTB, lesions of bones and joints (62.7%) and intrathoracic lymph nodes (19.5%) predominate. HIV-positive patients are more common in the ITLN group. MBT is most often detected in the following localizations of extrapulmonary process: intrathoracic and peripheral lymph nodes, pleural tuberculosis. The most highly informative method of examination of biological nonrespiratory material for detection of MBT in extrapulmonary localization is molecular genetic study.
{"title":"Extrapulmonary tuberculosis: diagnostic features","authors":"M. A. Yudenko, I. Buinevich, D. Y. Rusanau","doi":"10.51523/2708-6011.2023-20-1-06","DOIUrl":"https://doi.org/10.51523/2708-6011.2023-20-1-06","url":null,"abstract":"Objective. To study demographic, clinical characteristics and concomitant pathology of patients with extrapulmonary tuberculosis (EPTB) in Gomel city and Gomel region for the period 2017-2021. To evaluate the informative value of different techniques for the detection of Mycobacterium tuberculosis (MBT) in non-respiratory samples in the diagnosis of extrapulmonary tuberculosis.Materials and methods. A retrospective study of extrapulmonary tuberculosis cases registered from 2017 to 2021 in Gomel and Gomel region (308 patients) was carried out. The results of microscopic, bacteriological and molecular genetic methods of non-respiratory and respiratory samples relevant in the diagnosis of extrapulmonary forms of tuberculosis were analyzed.Results. Demographic and clinical characteristics of patients with EPTB in Gomel and Gomel region for the period 20172021 were revealed. Concomitant pathology in patients with EPTB was analyzed, the features of EPTB diagnostics were studied. It was determined that EPTB is more susceptible to males aged 31 to 50 years and to women aged over 60 years. EPTB is more frequently diagnosed in patients from urban areas and when patients come to medical institutions with nonspecific complaints, except for intrathoracic lymph node tuberculosis (ITLN).Conclusion. In the structure of clinical forms of EPTB, lesions of bones and joints (62.7%) and intrathoracic lymph nodes (19.5%) predominate. HIV-positive patients are more common in the ITLN group. MBT is most often detected in the following localizations of extrapulmonary process: intrathoracic and peripheral lymph nodes, pleural tuberculosis. The most highly informative method of examination of biological nonrespiratory material for detection of MBT in extrapulmonary localization is molecular genetic study.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131698279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-05DOI: 10.51523/2708-6011.2022-19-4-18
H. V. Udovenka, D. V. Osipenko, S. P. Salivonchik, A. A. Skarakhodau, V. V. Lavachkin, O. V. Chirkova
Objective. To evaluate the efficiency and safety of using two thoracic internal arteries during myocardial revascularization.Materials and methods. The study included 32 patients over 18 years of age who were operated on for coronary artery diseases using two internal arteries as an auto-graft. The incidence of postoperative complications was assessed taking into account the proposed criteria for selecting patients.Results. No increase in the number of postoperative complications in the early postoperative period was detected during bilateral internal thoracic artery coronary artery bypass graft.Conclusion. Coronary bypass grafting using two internal thoracic arteries under general multicomponent balanced anesthesia is an effective and safe method of myocardial revascularization. It does not increase the risk of complications in the postoperative period with proper selection of patients.
{"title":"Results of myocardial revascularization using two thoracic internal arteries under general anesthesia","authors":"H. V. Udovenka, D. V. Osipenko, S. P. Salivonchik, A. A. Skarakhodau, V. V. Lavachkin, O. V. Chirkova","doi":"10.51523/2708-6011.2022-19-4-18","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-18","url":null,"abstract":"Objective. To evaluate the efficiency and safety of using two thoracic internal arteries during myocardial revascularization.Materials and methods. The study included 32 patients over 18 years of age who were operated on for coronary artery diseases using two internal arteries as an auto-graft. The incidence of postoperative complications was assessed taking into account the proposed criteria for selecting patients.Results. No increase in the number of postoperative complications in the early postoperative period was detected during bilateral internal thoracic artery coronary artery bypass graft.Conclusion. Coronary bypass grafting using two internal thoracic arteries under general multicomponent balanced anesthesia is an effective and safe method of myocardial revascularization. It does not increase the risk of complications in the postoperative period with proper selection of patients.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133573143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-05DOI: 10.51523/2708-6011.2022-19-4-17
N. N. Usova, A. P. Savostin, A. I. Savitsky
Objective. To evaluate the effectiveness of using the “Painmetrica” software for the diagnosis and selection of treatment for pain in degenerative diseases of the spine. Materials and methods. Software “Painmetrica” was developed for the diagnosis and selection of treatment for pain in degenerative diseases of the spine. Through a bidirectional nonrandomized controlled trial, its effectiveness was evaluated using telephone interviews with 42 patients. For comparison, a telephone interview was conducted with 47 patients for whom the Panimetrica program had not been used in the treatment.Results. The effectiveness of using “Painmetrica” software for the diagnosis and selection of treatment for patients with back pain was demonstrated. In the main group, the decrease in pain syndrome tended to differ due to an increase in the number of patients in whom pain was relieved by more than 50% and completely disappeared (p = 0,09 according to the two-tailed Fisher’s exact test). Patients treated with Painmetrica algorithms experienced sleep recovery due to a decrease in pain: changes persisted in 12 cases (28,6%), while in the comparison group, sleep changes remained in 24 patients (51,1%) (p=0,05 according to two-tailed Fisher’s exact test). Against the background of effective pain relief in patients who used Painmetrica, there was a decrease in the use of non-steroidal anti-inflammatory drugs (NSAIDs) (17 patients (40,5%) of the main group versus 36 patients (76,6%) of the control group, p = 0,001 according to the twotailed Fisher’s exact test ). At the same time, only 8 patients (19.1%) in the main group and 30 patients (63.8%) in the comparison group (p < 0.001 according to Fisher’s two-sided exact test) indicated the need to consult a neurologist.Conclusion. The effectiveness of the use of “Painmetrica” software for the diagnosis and selection of treatment of patients with degenerative diseases of the spine on an outpatient basis in relation to the need for patients to use nonsteroidal anti-inflammatory drugs, the need for additional consultation of a neurologist, as well as effective relief of sleep disorders caused by pain were demonstrated.
{"title":"The effectiveness of using “Painmetrica” software for the diagnosis and selection of treatment for chronic pain syndrome in degenerative diseases of the spine","authors":"N. N. Usova, A. P. Savostin, A. I. Savitsky","doi":"10.51523/2708-6011.2022-19-4-17","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-17","url":null,"abstract":"Objective. To evaluate the effectiveness of using the “Painmetrica” software for the diagnosis and selection of treatment for pain in degenerative diseases of the spine. Materials and methods. Software “Painmetrica” was developed for the diagnosis and selection of treatment for pain in degenerative diseases of the spine. Through a bidirectional nonrandomized controlled trial, its effectiveness was evaluated using telephone interviews with 42 patients. For comparison, a telephone interview was conducted with 47 patients for whom the Panimetrica program had not been used in the treatment.Results. The effectiveness of using “Painmetrica” software for the diagnosis and selection of treatment for patients with back pain was demonstrated. In the main group, the decrease in pain syndrome tended to differ due to an increase in the number of patients in whom pain was relieved by more than 50% and completely disappeared (p = 0,09 according to the two-tailed Fisher’s exact test). Patients treated with Painmetrica algorithms experienced sleep recovery due to a decrease in pain: changes persisted in 12 cases (28,6%), while in the comparison group, sleep changes remained in 24 patients (51,1%) (p=0,05 according to two-tailed Fisher’s exact test). Against the background of effective pain relief in patients who used Painmetrica, there was a decrease in the use of non-steroidal anti-inflammatory drugs (NSAIDs) (17 patients (40,5%) of the main group versus 36 patients (76,6%) of the control group, p = 0,001 according to the twotailed Fisher’s exact test ). At the same time, only 8 patients (19.1%) in the main group and 30 patients (63.8%) in the comparison group (p < 0.001 according to Fisher’s two-sided exact test) indicated the need to consult a neurologist.Conclusion. The effectiveness of the use of “Painmetrica” software for the diagnosis and selection of treatment of patients with degenerative diseases of the spine on an outpatient basis in relation to the need for patients to use nonsteroidal anti-inflammatory drugs, the need for additional consultation of a neurologist, as well as effective relief of sleep disorders caused by pain were demonstrated.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122080111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-04DOI: 10.51523/2708-6011.2022-19-4-15
R. Kamilova, A. R. Nosirova, Zh. A. Kamilov, L. Isakova
Objective. To carry out a comparative assessment of physical development indexes of pupils of general education schools with hot meals and a buffet type of catering.Materials and methods. There were examined 432 schoolchildren from 7 to 15 years old, divided into two groups: group 1 – pupils of general education schools in which there were canteens based on food raw materials and semifinished products; group 2 – pupils of general education schools with a buffet with implementation of ready meals, confectionery, drinks, etc. To study the main indexes of physical development somatometric research methods were used. Differences at p≤0,05 were considered statistically significant.Results. The absence of hot meal service contributes to an increase in the number of children with body length below average in 2.3-15.7 times (among girls aged 11-15 – p<0.001); with excess body weight – 1.2-5 times (among boys aged 7-10 – p<0.01), with reduced body weight – 1.4-1.7 times; with increased and excessive nutrition – 1.3-11.6 times (among boys - p<0.05-0.001, and among girls – p<0.05). Consequently, the absence of hot meal service in general education schools affects the indicators of the physical development of children: deviations from the mean values in body length being more frequently observed in girls, and in body weight in boys.Conclusion. The absence of hot meal service in education institutions negatively affects the physical development of students. For the harmonious development of children, the formation of hygienic skills of healthy eating and a conscious attitude to the choice of a proper diet, it is necessary to organize hot school meals and strengthen sanitary and educational work.
{"title":"Comparative assessment of physical development indicators of pupils in general education schools with different types of food service operation","authors":"R. Kamilova, A. R. Nosirova, Zh. A. Kamilov, L. Isakova","doi":"10.51523/2708-6011.2022-19-4-15","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-15","url":null,"abstract":"Objective. To carry out a comparative assessment of physical development indexes of pupils of general education schools with hot meals and a buffet type of catering.Materials and methods. There were examined 432 schoolchildren from 7 to 15 years old, divided into two groups: group 1 – pupils of general education schools in which there were canteens based on food raw materials and semifinished products; group 2 – pupils of general education schools with a buffet with implementation of ready meals, confectionery, drinks, etc. To study the main indexes of physical development somatometric research methods were used. Differences at p≤0,05 were considered statistically significant.Results. The absence of hot meal service contributes to an increase in the number of children with body length below average in 2.3-15.7 times (among girls aged 11-15 – p<0.001); with excess body weight – 1.2-5 times (among boys aged 7-10 – p<0.01), with reduced body weight – 1.4-1.7 times; with increased and excessive nutrition – 1.3-11.6 times (among boys - p<0.05-0.001, and among girls – p<0.05). Consequently, the absence of hot meal service in general education schools affects the indicators of the physical development of children: deviations from the mean values in body length being more frequently observed in girls, and in body weight in boys.Conclusion. The absence of hot meal service in education institutions negatively affects the physical development of students. For the harmonious development of children, the formation of hygienic skills of healthy eating and a conscious attitude to the choice of a proper diet, it is necessary to organize hot school meals and strengthen sanitary and educational work.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127575505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-04DOI: 10.51523/2708-6011.2022-19-4-11
I. Nazarenko, A. Yurkovskiy, E. Voropaev
Objective. Тo evaluate the possibility of using instrumental methods (spirometry and ultrasound diagnostics) for dynamic monitoring of patients with COVID-19-associated lung disease.Materials and methods. To achieve this goal, we performed a comprehensive instrumental diagnosis of respiratory system lesions in 58 patients (age - 56.0 years [31; 65]) with confirmed COVID-19, followed by examination of indexes of external respiratory function and ultrasound pattern in the dynamics.Results. In the process of dynamic observation, there was a parallelism of changes in the indexes of external respiratory function and changes revealed by lung ultrasound in patients with COVID-19.Conclusion.Combination of such methods of lung condition examination as spirometry and ultrasound diagnostics allows effective dynamic monitoring of COVID-19 patients without use of imaging methods associated with radiation exposure.
{"title":"Possibilities of using instrumental diagnostic methods for dynamic monitoring of patients with COVID-19-associated lung disease","authors":"I. Nazarenko, A. Yurkovskiy, E. Voropaev","doi":"10.51523/2708-6011.2022-19-4-11","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-11","url":null,"abstract":"Objective. Тo evaluate the possibility of using instrumental methods (spirometry and ultrasound diagnostics) for dynamic monitoring of patients with COVID-19-associated lung disease.Materials and methods. To achieve this goal, we performed a comprehensive instrumental diagnosis of respiratory system lesions in 58 patients (age - 56.0 years [31; 65]) with confirmed COVID-19, followed by examination of indexes of external respiratory function and ultrasound pattern in the dynamics.Results. In the process of dynamic observation, there was a parallelism of changes in the indexes of external respiratory function and changes revealed by lung ultrasound in patients with COVID-19.Conclusion.Combination of such methods of lung condition examination as spirometry and ultrasound diagnostics allows effective dynamic monitoring of COVID-19 patients without use of imaging methods associated with radiation exposure.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128540628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-04DOI: 10.51523/2708-6011.2022-19-4-16
H. Ramanau, E. Rudenka, E. Platoshkin, A. A. Ramaniva
Objective. To calculate the number of lost (including healthy) years of life in patients aged 50 years and older with proximal femur fractures (PF) in the Republic of Belarus based on primary incidence data and evaluate the cost-effectiveness of the therapeutic model for the secondary prevention of osteoporotic fractures.Materials and methods. A comprehensive assessment of health losses was carried out using DALY analysis based on our own epidemiological data on the primary incidence of PF and is presented in years of life lost to due to premature mortality and the years lived with a disability. The alendronic acid (AA) prescription after a primary PF fracture was proposed for secondary prevention of PF fractures. The cost-effectiveness was calculated based on the cost of one saved (including healthy) year in relation to the national GDP per capita.Results. In the Republic of Belarus taking into account sex and age structure of the population it is expected to have a total of 2867 PF fractures in men (558 atal cases during the first year) and 7921 (2382 fatal cases) in women per year. The total number of lost (including healthy) years of life due to osteoporotic PF fractures was 8719.0 in men and 8169.9 in women. The administration of AA after PF fracture will save 1806.11 years of healthy life. The cost of one saved (incl. healthy) year was 1044.2 BYN/year for men (6.5% of GDP per capita) and 1720.1 BYN/year for women (10.8% of GDP per capita).Conclusion. Prescription of antiresorptive therapy in the form of alendronic acid to men and women aged 50 years and older after a osteoporotic PF fracture for prevention of recurrent osteoporotic fractures is highly cost-effective and can be considered when assessing the threshold of intervention in treating patients with osteoporosis in the Republic of Belarus.
{"title":"Secondary prevention of osteoporotic fractures in the Republic of Belarus: DALY-analysis and cost-effectiveness","authors":"H. Ramanau, E. Rudenka, E. Platoshkin, A. A. Ramaniva","doi":"10.51523/2708-6011.2022-19-4-16","DOIUrl":"https://doi.org/10.51523/2708-6011.2022-19-4-16","url":null,"abstract":"Objective. To calculate the number of lost (including healthy) years of life in patients aged 50 years and older with proximal femur fractures (PF) in the Republic of Belarus based on primary incidence data and evaluate the cost-effectiveness of the therapeutic model for the secondary prevention of osteoporotic fractures.Materials and methods. A comprehensive assessment of health losses was carried out using DALY analysis based on our own epidemiological data on the primary incidence of PF and is presented in years of life lost to due to premature mortality and the years lived with a disability. The alendronic acid (AA) prescription after a primary PF fracture was proposed for secondary prevention of PF fractures. The cost-effectiveness was calculated based on the cost of one saved (including healthy) year in relation to the national GDP per capita.Results. In the Republic of Belarus taking into account sex and age structure of the population it is expected to have a total of 2867 PF fractures in men (558 atal cases during the first year) and 7921 (2382 fatal cases) in women per year. The total number of lost (including healthy) years of life due to osteoporotic PF fractures was 8719.0 in men and 8169.9 in women. The administration of AA after PF fracture will save 1806.11 years of healthy life. The cost of one saved (incl. healthy) year was 1044.2 BYN/year for men (6.5% of GDP per capita) and 1720.1 BYN/year for women (10.8% of GDP per capita).Conclusion. Prescription of antiresorptive therapy in the form of alendronic acid to men and women aged 50 years and older after a osteoporotic PF fracture for prevention of recurrent osteoporotic fractures is highly cost-effective and can be considered when assessing the threshold of intervention in treating patients with osteoporosis in the Republic of Belarus.","PeriodicalId":336889,"journal":{"name":"Health and Ecology Issues","volume":"519 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123124819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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