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ASSESSMENT OF GLYCEMIA VARIABILITY IN PERSONS WITH TYPE 1 DIABETES MELLITUS USING THE GLINVA PROGRAM 使用glinva程序评估1型糖尿病患者血糖变异性
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2022-6-1-51-56
M. Dudina, I. Bondar
High glycemia variability (GV) has a significant impact on the progression of complications in patients with diabetes mellitus (DM). In the course of research, using the GLINVA program based on the data of continuous glucose monitoring, an in-depth analysis of GV was carried out in 12 patients with type 1 diabetes mellitus who were on the insulin pump therapy and had compensation according to the level of glycated hemoglobin. It was found out that even with good diabetes compensation, the GV remains high enough, which can influence the development of complications. The use of variability indices in assessing the glycemic profile in patients with type 1 diabetes mellitus will help in correcting insulin therapy and timely prevention of complications.
高血糖变异性(GV)对糖尿病(DM)患者并发症的进展有重要影响。在研究过程中,利用基于连续血糖监测数据的GLINVA程序,对12例接受胰岛素泵治疗并根据糖化血红蛋白水平进行代偿的1型糖尿病患者的GV进行了深入分析。研究发现,即使有良好的糖尿病代偿,GV仍然足够高,这可能会影响并发症的发生。利用变异性指标评价1型糖尿病患者的血糖状况有助于纠正胰岛素治疗和及时预防并发症。
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引用次数: 0
THE ROLE OF FUNCTIONAL HEMISPHERIC ASYMMETRY IN PSYCHOPHYSIOLOGICAL ADAPTATION OF STUDENTS 功能性半球不对称在学生心理生理适应中的作用
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2021-4-57-65
V. Kulikov, L. Antropova
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引用次数: 0
INFLUENCE OF NEURO-LIKE DYNAMIC ELECTRICAL STIMULATION ON NEURAL CONDUCTIVITY AND BASAL MICROCIRCULATION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH PERIPHERAL NEUROPATHY 神经样动态电刺激对2型糖尿病合并周围神经病变患者神经传导及基础微循环的影响
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2021-1-51-56
V. Drobyshev, L. Shpagina, G. S. Logacheva, S.Yu. Ryavkin, А.А. Vlasov, Еkaterinburg «Tronitek»
The results of the study of the electric pulse therapy effect on the state of neural conductivity and microvasculature in 60 patients with moderate type 2 diabetes mellitus (DM2), accompanied by the peripheral sensory neuropathy, are presented. A comparative double-blind, placebo-controlled study of the inclusion of neuro-like dynamic electrical stimulation in the rehabilitation course was carried out. By the end of the rehabilitation course, the patients of the experimental group showed an increase in the velocity of excitation propagation along the tibial and peroneal nerves, restoration of the impaired spontaneous activity of deafferentated central neurons at the spinal and cerebral levels, and an improvement of basal microcirculation indices.
本文报道了电脉冲治疗60例伴有周围感觉神经病变的中度2型糖尿病(DM2)患者的神经传导和微血管状态的变化。一项比较双盲,安慰剂对照研究的神经样动态电刺激纳入康复过程中进行。康复疗程结束时,实验组患者沿胫腓神经兴奋传播速度增加,脊髓和脑水平失联中枢神经元受损的自发活动恢复,基础微循环指数改善。
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引用次数: 0
THERAPEUTIC NUTRITION IN FOOD ALLERGY: NOT THAT SIMPLE 食物过敏的治疗性营养:没那么简单
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2022-6-1-30-37
N. S. Ishkova, L. Kaznacheeva, K. S. Kaznacheev, N. V. Geraschenko
Purpose of the study. To assess the effectiveness of elimination diet therapy using therapeutic formulas in children with cow's milk protein allergy according to a 5-year follow-up. Materials and methods. A prospective, single-center, open, uncontrolled study was conducted. We observed 99 children with atopic dermatitis and allergy to cow's milk protein (CMP), the average age at the beginning of the study was 4.6 ± 0.8 months. The results of clinical observation, clinical assessment of the function of the digestive organs, and the level of the IgE to CMP were used as control methods. The selection of formulas for clinical nutrition at the stage of elimination diet therapy was carried out differentially, depending on the severity of the skin syndrome and gastrointestinal manifestations. The follow-up period was 5 years. Results. Food allergy manifested itself in 34 (34.3%) children only as a skin syndrome (atopic dermatitis), in 65 (65.7%) children as a skin syndrome in combination with gastrointestinal symptoms. In 67.7% of children, the use of therapeutic formulas based on highly hydrolyzed cow's milk protein and amino acids led to the normalization of the level of specific IgE. In mild atopic dermatitis, the average duration of the elimination period was 9.43 ± 2.7 months, in moderate atopic dermatitis, 19.3 ± 9.0 months, and in severe, 35.5 ± 14.8 months (p < 0.05). The number of patients with an exacerbation of an allergic disease with of the introduction of dairy products in mild, moderate and severe form of atopic dermatitis constituted 2 of 7, 6 of 48 (12.5%), 6 of 12 (50.0%) respectively (p < 0.05). Conclusion. In children with atopic dermatitis caused by food allergy to cow's milk proteins, the elimination diet in most cases (67.7%) leads to the normalization of the level of specific IgE, which makes it possible to start expanding the diet by introducing dairy products. The duration of the elimination period depends on the clinical manifestations of the allergic disease and the level of sensitization. When expanding the diet, patients should be provided with careful clinical and laboratory monitoring, including the determination of specific IgE to CMP. The high probability of persistent sensitization to CMP must be taken into account when prescribing elimination measures and drawing up rehabilitation programs for children with allergic diseases.
研究目的:通过对牛奶蛋白过敏儿童的5年随访,评估使用治疗配方消除饮食疗法的有效性。材料和方法。进行了一项前瞻性、单中心、开放、非对照研究。我们观察了99例患有特应性皮炎并对牛奶蛋白(CMP)过敏的儿童,研究开始时的平均年龄为4.6±0.8个月。以临床观察结果、消化器官功能临床评价和血清IgE to CMP水平为对照。根据皮肤综合征和胃肠道表现的严重程度,在消除饮食疗法阶段进行临床营养配方的选择。随访期为5年。结果。34例(34.3%)儿童食物过敏仅表现为皮肤综合征(特应性皮炎),65例(65.7%)儿童食物过敏表现为皮肤综合征并伴有胃肠道症状。在67.7%的儿童中,使用基于高度水解的牛奶蛋白和氨基酸的治疗配方导致特异性IgE水平正常化。轻度特应性皮炎的平均消除期为9.43±2.7个月,中度特应性皮炎的平均消除期为19.3±9.0个月,重度特应性皮炎的平均消除期为35.5±14.8个月(p < 0.05)。在轻度、中度和重度特应性皮炎患者中,7例中有2例、48例中有6例(12.5%)、12例中有6例(50.0%)出现乳制品引起的变应性疾病加重(p < 0.05)。结论。在对牛奶蛋白食物过敏引起的特应性皮炎患儿中,消除饮食在大多数情况下(67.7%)导致特异性IgE水平正常化,这使得通过引入乳制品开始扩大饮食成为可能。消除期的长短取决于变态反应性疾病的临床表现和致敏程度。在扩大饮食时,应为患者提供仔细的临床和实验室监测,包括测定CMP的特异性IgE。在为患有过敏性疾病的儿童制定消除措施和制定康复计划时,必须考虑到对CMP持续致敏的高概率。
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引用次数: 0
RESULTS OF TREATMENT OF THE ESOPHAGUS CHEMICAL BURNS IN CHILDREN 儿童食道化学烧伤的治疗效果
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2021-1-40-45
P. Pavlushin, A. Gramzin, P. Trushin, G. E. Ivanovsky, Y. Chikinev
A retrospective analysis of 49 cases of the initial hospital admission on account of chemical burn of esophagus to the Children's City Hospital No. 1 during the period from 2011 to 2015 was carried out. Patients were divided into 2 groups depending on the chemical agent: group 1 of 25 children (48,9 %) with burns of the esophagus with 70% vinegar essence, and group 2 of 24 patients, in whom burns were caused by alkaline solutions of household chemicals. Statistically significant difference between groups was found in the bed-day: in group 1, the duration of stay was 29,9 ± 16,4 days, and in group 2 — 45,2 ± 27,6 days. And also in the number of bougienages: over the 1st year, in group 1 the median was 3 bougienages per year, with the maximum value — 21, minimum — 1; in group 2, the mediam was 7 bougienages per year, with the maximum value being 24, and the minimum — 2 procedures. Thus, chemical burns of the esophagus remain an urgent problem of childhood. The nature of the lesion and the time of rehabilitation depend on the chemical agent.
回顾性分析2011 - 2015年在市第一儿童医院因食道化学烧伤首次住院的49例患者。根据化学试剂的不同将患者分为两组:第一组25例(48.9%)食管烧伤患儿使用70%醋香精;第二组24例患者使用家用化学药品碱性溶液。两组住院天数比较差异有统计学意义:1组为29,9±16,4 d,2组为45,2±27,6 d。在花的数量上也是如此在第一年里,第一组的中位数是每年3朵花,最大值是21朵,最小值是1朵;组2中位数为每年7根,最大值为24根,最小值为- 2根。因此,食道的化学烧伤仍然是儿童的一个紧迫问题。损伤的性质和康复的时间取决于化学药剂。
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引用次数: 0
OVARIAN CANCER: A MODERN LOOK ON TREATMENT 卵巢癌:现代治疗观
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2021-4-12-18
A.O. Vigriyanova, V. M. Grinvald, A.A. Nikitchuk, V. Voytsitsky, V. Lebedeva, I. V. Skuridina, A. Tarkhov, O. A. Tkachuk
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引用次数: 0
COMPUTED TOMOGRAPHY VIRTUAL BRONCHOSCOPY IN PATIENTS WITH PULMONARY TUBERCULOSIS 肺结核患者的计算机断层虚拟支气管镜检查
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2021-4-23-29
Yu.A. Chaadaeva, N. Gorbunov, A. Dergilev
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引用次数: 0
PREVENTION OF INFLAMMATION OF PERIODONTAL TISSUES IN ORTHODONTIC TREATMENT OF DENTAL-MAXILLARY ANOMALIES 牙齿-上颌畸形正畸治疗牙周组织炎症的预防
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2021-1-11-15
К.S. Shchelkunov, P. Zhelezny, А.P. Zheleznaya, Е.Yu. Apraksina, М.V. Nikolskaya, E. Piven, N. V. Kuznetsova
The study was carried out in 192 patients aged 18–25 years who underwent orthodontic treatment of dental-maxillary anomalies. We singled out 3 groups of patients who, after the orthodontic appliances being put on, were implemented various preventive measures against the inflammatory process. In the period before treatment, after 7 days, after 1, 3 and 12 months in the mixed saliva, the activity of lysozyme, the level of secretory immunoglobulin A and interleukins were determined. Measurements were performed with a vertical spectrophotometer Multiscan MCC 340. In all groups of patients, there was a gradual increase in the indicators of lysozyme activity, the level of secretory immunoglobulin A and interleukins; so by 3 months and by 1 year they came to their initial values. Rapid normalization of these indicators was noted in the third group of patients, where a full range of preventive measures was carried out using professional hygiene, antibacterial and immune therapy. The use of the appliances for orthodontic treatment is accompanied by the inflammatory process. The combined use of oral hygiene, antibacterial and immune therapy is most indicated in the prevention of the inflammatory process in the treatment of dental-maxillary anomalies.
研究对象为192例年龄在18-25岁之间,接受牙齿-上颌畸形正畸治疗的患者。我们挑选了3组患者,在佩戴正畸矫治器后,对炎症过程实施了各种预防措施。分别在治疗前、治疗后7天、治疗后1个月、3个月和12个月测定混合唾液溶菌酶活性、分泌性免疫球蛋白A和白细胞介素水平。用Multiscan MCC 340垂直分光光度计进行测量。各组患者溶菌酶活性、分泌性免疫球蛋白a、白细胞介素等指标均逐渐升高;3个月和1年后,它们回到了初始值。在第三组患者中,这些指标迅速恢复正常,采用专业卫生、抗菌和免疫疗法,采取了全面的预防措施。使用矫治器进行正畸治疗是伴随着炎症过程的。口腔卫生、抗菌和免疫治疗的联合应用在预防牙颌畸形的炎症过程中最为有效。
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引用次数: 0
X-RAY DIAGNOSTICS OF BRAIN DAMAGE IN UNIDENTIFIED HIV INFECTION 不明HIV感染脑损伤的x线诊断
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2021-2-9-14
A. Sudarkina, A. Dergilev, А.А. Kuzovkova, A. P. Nadeev, N. Gorbunov
Brain damage can be observed at any stage of HIV infection, and the spectrum of its causes is extremely diverse. Neuroimaging techniques play a key role in assessing brain lesions. The article describes a clinical case of multifocal brain damage in a patient with undiagnosed HIV infection, discusses the possibilities of various methods of radiation examination for differential diagnosis, demonstrates the most important role of a comprehensive clinical examination for making a diagnosis.
在艾滋病毒感染的任何阶段都可以观察到脑损伤,其原因也非常多样。神经成像技术在评估脑损伤中起着关键作用。本文介绍了一例未确诊的HIV感染患者的多灶性脑损伤的临床病例,讨论了各种放射检查方法鉴别诊断的可能性,论证了综合临床检查对诊断的最重要作用。
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引用次数: 0
THE USE OF CONTOUR LARYNGOPLASTY IN LARYNGEAL HEMIPLEGIA IN PATIENTS WITH CORONAVIRAL INFECTION 轮廓喉成形术在冠状病毒感染喉偏瘫患者中的应用
Pub Date : 1900-01-01 DOI: 10.31549/2541-8289-2021-3-32-36
R.O. Stanishevsky, A. Kiselev
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引用次数: 0
期刊
Sibirskij medicinskij vestnik
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