Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-4-13-23
L. Shpagina, M. Zenkova, I. Shpagin, E. Anikina, O. Kotova, E. Logashenko
Introduction. Occupational chronic obstructive pulmonary disease (OCOPD) is characterized by steadily progressive persistent bronchial obstruction and emphysema, which leads to disability and reduced life expectancy of patients. Industrial aerosols are one of the main occupational health risks. According to Federal State Statistics Service, 4.5% of all workers are exposed to aerosols of predominantly fibrogenic action, 7.7% – to a chemical factor. At present, the determination of the physicochemical properties of nanoparticles and the study of their effect on the phenotype of occupational bronchopulmonary pathology are still insufficiently studied. Aim of the research. To identify clinical, functional, cellular and molecular features of the phenotype of occupational chronic obstructive pulmonary disease under exposure to aerosols with unintentional nanoparticles of various compositions. Materials and methods. A single-center cohort study was performed. Patients with OCOPD (GOLD 2011-2021 criteria) who worked under conditions of exposure to aerosols containing unintentional nanoparticles were included (n = 70). Comparison group – COPD due to tobacco smoking (n = 70), control – conditionally healthy (n = 70). The groups are comparable in terms of demographic indicators, duration of the disease. Nanoparticles in the air of the working area were determined by inductively coupled plasma atomic emission spectrometry (ICP-AES) and scanning electron microscopy. At the workplaces, in 36 persons, the mass concentration of metal nanoparticles was the highest, in 34 persons – that of silica nanoparticles. Spirography, body plethysmography, assessment of the diffusing capacity of the lungs (DLco/Va) for carbon monoxide (DLco/Va), cytological examination of induced sputum were performed. Markers of cellular inflammation and fibrosis were studied: interleukin-1β (IL1-β), interleukin-5 (IL-5), C-reactive protein (CRP), fibroblast growth factor-2 (FGF-2), transforming growth factor-β1 (TGF-β1), procollagen type 3 N-terminal propeptide (PIIINP), matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-9 (MMP-9), soluble vascular cell adhesion molecule-1 (sVCAM 1) and distribution subpopulations of blood monocytes by flow cytometry. Correlations were determined by the method of linear regression. Results. The clinical and functional peculiar characteristics of COPD when exposed to aerosols with metal nanoparticles are: the greatest severity of dyspnea according to mMRC scale 2.35 ± 0.120 points, dry cough with paroxysms 75.0%, low quality of life 70.8 ± 5.68 points, ventilation function of the lungs with the greatest severity of bronchial obstruction (Raw 0.66 kPa s/l, FEV1 36%) and static pulmonary hyperinflation (functional residual capacity (FRC) 192%, residual volume of the lungs (PRV) 187%), maximum pulmonary hypertension (37 mm Hg), the lowest values of DLco 36%. The cellular and molecular composition in OCOPD from exposure to metal nanoparticles is chara
{"title":"CLINICAL AND FUNCTIONAL, CELLULAR AND MOLECULAR CHARACTERISTICS OF OCCUPATIONAL CHRONIC OBSTRUCTIVE PULMONARY DISEASE DEPENDING ON THE COMPOSITION OF UNINTENTIONAL NANOPARTICLES","authors":"L. Shpagina, M. Zenkova, I. Shpagin, E. Anikina, O. Kotova, E. Logashenko","doi":"10.31549/2541-8289-2022-6-4-13-23","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-4-13-23","url":null,"abstract":"Introduction. Occupational chronic obstructive pulmonary disease (OCOPD) is characterized by steadily progressive persistent bronchial obstruction and emphysema, which leads to disability and reduced life expectancy of patients. Industrial aerosols are one of the main occupational health risks. According to Federal State Statistics Service, 4.5% of all workers are exposed to aerosols of predominantly fibrogenic action, 7.7% – to a chemical factor. At present, the determination of the physicochemical properties of nanoparticles and the study of their effect on the phenotype of occupational bronchopulmonary pathology are still insufficiently studied. Aim of the research. To identify clinical, functional, cellular and molecular features of the phenotype of occupational chronic obstructive pulmonary disease under exposure to aerosols with unintentional nanoparticles of various compositions. Materials and methods. A single-center cohort study was performed. Patients with OCOPD (GOLD 2011-2021 criteria) who worked under conditions of exposure to aerosols containing unintentional nanoparticles were included (n = 70). Comparison group – COPD due to tobacco smoking (n = 70), control – conditionally healthy (n = 70). The groups are comparable in terms of demographic indicators, duration of the disease. Nanoparticles in the air of the working area were determined by inductively coupled plasma atomic emission spectrometry (ICP-AES) and scanning electron microscopy. At the workplaces, in 36 persons, the mass concentration of metal nanoparticles was the highest, in 34 persons – that of silica nanoparticles. Spirography, body plethysmography, assessment of the diffusing capacity of the lungs (DLco/Va) for carbon monoxide (DLco/Va), cytological examination of induced sputum were performed. Markers of cellular inflammation and fibrosis were studied: interleukin-1β (IL1-β), interleukin-5 (IL-5), C-reactive protein (CRP), fibroblast growth factor-2 (FGF-2), transforming growth factor-β1 (TGF-β1), procollagen type 3 N-terminal propeptide (PIIINP), matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-9 (MMP-9), soluble vascular cell adhesion molecule-1 (sVCAM 1) and distribution subpopulations of blood monocytes by flow cytometry. Correlations were determined by the method of linear regression. Results. The clinical and functional peculiar characteristics of COPD when exposed to aerosols with metal nanoparticles are: the greatest severity of dyspnea according to mMRC scale 2.35 ± 0.120 points, dry cough with paroxysms 75.0%, low quality of life 70.8 ± 5.68 points, ventilation function of the lungs with the greatest severity of bronchial obstruction (Raw 0.66 kPa s/l, FEV1 36%) and static pulmonary hyperinflation (functional residual capacity (FRC) 192%, residual volume of the lungs (PRV) 187%), maximum pulmonary hypertension (37 mm Hg), the lowest values of DLco 36%. The cellular and molecular composition in OCOPD from exposure to metal nanoparticles is chara","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"50 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114019015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2021-2-53-56
А. Kiseleva, P. Maksimenko, А.N. Sultanova, D. Ioanidi
Aim: to assess the asthenia and depression level in children with tension-type headaches (TTH), and their social role in the bullying structure of the school class. Results and discussion: in the social relations context, it was revealed that adolescents with TTH most often have such types of accentuations as emotiveness (17,25 ± 2,12) and hyperthymicity (16,12 ± 4,51). Besides, the adolescents have subdepression with a predominance of such symptoms as ineffectiveness at school and their own ineffectiveness. The mean score for depression was 61,22 ± 12,36. A low level of asthenia was revealed (53,78 ± 7,08), the level of depression was above average (61,22 ± 12,36). In the bullying structure of the class, the use of the role of the defender is often noted (9,22 ± 2,33), the responses characteristic of the initiators of the bullying are least often chosen (4,11 ± 2,67). Conclusion: despite of the fact that children suffer from TTH, they want to remain active members of society, show goodwill towards their team, and are not prone to aggression; they cannot always assess their positive qualities objectively, which is why they can be dissatisfied with themselves, have an intrapersonal conflict in view of the prevalence of the Ideal Self over the Real Self, and also tend to form an accentuated personality with emotive and hyperthymic features.
{"title":"THE EMOTIONAL SPHERE CHARACTERISTICS OF CHILDREN AND ADOLESCENTS WITH TENSION-TYPE HEADACHES","authors":"А. Kiseleva, P. Maksimenko, А.N. Sultanova, D. Ioanidi","doi":"10.31549/2541-8289-2021-2-53-56","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-2-53-56","url":null,"abstract":"Aim: to assess the asthenia and depression level in children with tension-type headaches (TTH), and their social role in the bullying structure of the school class. Results and discussion: in the social relations context, it was revealed that adolescents with TTH most often have such types of accentuations as emotiveness (17,25 ± 2,12) and hyperthymicity (16,12 ± 4,51). Besides, the adolescents have subdepression with a predominance of such symptoms as ineffectiveness at school and their own ineffectiveness. The mean score for depression was 61,22 ± 12,36. A low level of asthenia was revealed (53,78 ± 7,08), the level of depression was above average (61,22 ± 12,36). In the bullying structure of the class, the use of the role of the defender is often noted (9,22 ± 2,33), the responses characteristic of the initiators of the bullying are least often chosen (4,11 ± 2,67). Conclusion: despite of the fact that children suffer from TTH, they want to remain active members of society, show goodwill towards their team, and are not prone to aggression; they cannot always assess their positive qualities objectively, which is why they can be dissatisfied with themselves, have an intrapersonal conflict in view of the prevalence of the Ideal Self over the Real Self, and also tend to form an accentuated personality with emotive and hyperthymic features.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128309613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2023-7-1-63-67
K. Makarov, Yu.O. Kim, N. V. Kulikova, T.A. Drobysheva, I.G. Semenenko, L. A. Yakovleva, E.Yu. Anikina
Currently, healthcare is undergoing qualitative transformations in order to meet the growing medical and social needs of the population. The availability of qualified personnel is the most important component of the quality and accessibility of medical care, therefore, one of the main directions in the process of reforming the healthcare system is the training and retraining of healthcare personnel who possesses the modern knowledge. The quality of professional training of specialists with secondary medical education undoubtedly affects the quality of nur¬sing, as well as medical care in general.
{"title":"THE ROLE OF SIMULATION-BASED TRAINING IN IMPROVING THE QUALITY OF TEACHING FOR NURSES TO PROVIDE EMERGENCY CARE","authors":"K. Makarov, Yu.O. Kim, N. V. Kulikova, T.A. Drobysheva, I.G. Semenenko, L. A. Yakovleva, E.Yu. Anikina","doi":"10.31549/2541-8289-2023-7-1-63-67","DOIUrl":"https://doi.org/10.31549/2541-8289-2023-7-1-63-67","url":null,"abstract":"Currently, healthcare is undergoing qualitative transformations in order to meet the growing medical and social needs of the population. The availability of qualified personnel is the most important component of the quality and accessibility of medical care, therefore, one of the main directions in the process of reforming the healthcare system is the training and retraining of healthcare personnel who possesses the modern knowledge. The quality of professional training of specialists with secondary medical education undoubtedly affects the quality of nur¬sing, as well as medical care in general.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129334300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2023-7-2-41-47
A. Zatolokina, S. A. Loskutova, T. Belousova, N. Blagitko, I. Grinberg
Introduction. In parallel with the development of modern molecular genetic diagnostics, the frequency of diagnosing rare (orphan) syndromes in patients is increasing. Previously described clinical cases with a combination of certain syndromes, at the present stage are transformed into a genetically confirmed clinical diagnosis with the possibility of using targeted pathogenetically determined therapy. Muckle-Wells syndrome (MWS) is an autoinflammatory disease belonging to the group of Сryopyrin-Associated Periodic Syndrome (CAPS) which has an unfavorable outcome if left untreated. Aim. To demonstrate a family clinical case of a rare autoinflammatory disease. Materials and methods. History of the disease for 4 generations of the same family, clinical and laboratory manifestations in a 7-year-old patient, genetic testing to identify Muckle-Wells syndrome. Results. A clinical, genetic examination of two children and a mother from the same family was carried out, an autoinflammatory disease belonging to the group of cryopyrin-associated periodic syndromes was documented, biological therapy was prescribed. Conclusion. Increasing awareness of orphan diseases at the present stage contributes to earlier diagnosis, molecular genetic testing, taking into account family history and early administration of pathogenetic therapy with the ability to prevent the development of life-threatening complications.
{"title":"AUTO-INFLAMMATORY SYNDROMES IN DOCTOR'S PRACTICE ON THE EXAMPLE OF A FAMILY CASE OF MUKCLE-WELLS SYNDROME","authors":"A. Zatolokina, S. A. Loskutova, T. Belousova, N. Blagitko, I. Grinberg","doi":"10.31549/2541-8289-2023-7-2-41-47","DOIUrl":"https://doi.org/10.31549/2541-8289-2023-7-2-41-47","url":null,"abstract":"Introduction. In parallel with the development of modern molecular genetic diagnostics, the frequency of diagnosing rare (orphan) syndromes in patients is increasing. Previously described clinical cases with a combination of certain syndromes, at the present stage are transformed into a genetically confirmed clinical diagnosis with the possibility of using targeted pathogenetically determined therapy. Muckle-Wells syndrome (MWS) is an autoinflammatory disease belonging to the group of Сryopyrin-Associated Periodic Syndrome (CAPS) which has an unfavorable outcome if left untreated. Aim. To demonstrate a family clinical case of a rare autoinflammatory disease. Materials and methods. History of the disease for 4 generations of the same family, clinical and laboratory manifestations in a 7-year-old patient, genetic testing to identify Muckle-Wells syndrome. Results. A clinical, genetic examination of two children and a mother from the same family was carried out, an autoinflammatory disease belonging to the group of cryopyrin-associated periodic syndromes was documented, biological therapy was prescribed. Conclusion. Increasing awareness of orphan diseases at the present stage contributes to earlier diagnosis, molecular genetic testing, taking into account family history and early administration of pathogenetic therapy with the ability to prevent the development of life-threatening complications.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"27 11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130347404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2023-7-1-18-23
E. Stavsky, S. Zykov
Introduction. The use of personal protective equipment when performing work operations with especially hazardous materials largely determines the level of human performance and, finally, his activity safety. The microclimate of working areas in combination with the workload can have an unfavorable effect not only on the well-being of an employee in the process of performing important work operations, but can also result in cases of temporary disability due to illness. Aim. Physiological characteristics of the functional state of the body of women – employees of virological laboratories who used protective pneumatic suits for 2–3 years preceding this study. Materials and methods. Physiological studies were carried out in a thermal chamber, where labor loads and hygienic parameters of working areas were simulated, as well as the modes of operation of protective pneumatic suits by female virologists. The results obtained are compared with the data of studies in which the individuals of the control group took part as subjects. Results. An analysis of the results of physiological studies indicates a systematic overheating of the body of the subjects in the process of performing labor operations in protective pneumatic suits. A number of characteristic changes in physiological parameters have been established for cases observed during human adaptation to heat. Conclusion. The data obtained indicate that the pneumatic suit, in the design of which the convective method of normalizing the human temperature homeostasis is realized, requires the development of special operating modes for the implementation of continuous technological or laboratory operations in it. A set of methods for evaluating the performance of personal protective equipment in terms of the thermal state of the human body was tested, which makes it possible to determine the degree of influence of environmental factors and the labor process on the functional state of employees in order to predict it and establish the optimal mode of work.
{"title":"PHYSIOLOGICAL RESPONSES OF THE HUMAN BODY TO THE WORKING CONDITIONS IN PROTECTIVE PNEUMATIC SUITS IN VIROLOGICAL LABORATORIES","authors":"E. Stavsky, S. Zykov","doi":"10.31549/2541-8289-2023-7-1-18-23","DOIUrl":"https://doi.org/10.31549/2541-8289-2023-7-1-18-23","url":null,"abstract":"Introduction. The use of personal protective equipment when performing work operations with especially hazardous materials largely determines the level of human performance and, finally, his activity safety. The microclimate of working areas in combination with the workload can have an unfavorable effect not only on the well-being of an employee in the process of performing important work operations, but can also result in cases of temporary disability due to illness. Aim. Physiological characteristics of the functional state of the body of women – employees of virological laboratories who used protective pneumatic suits for 2–3 years preceding this study. Materials and methods. Physiological studies were carried out in a thermal chamber, where labor loads and hygienic parameters of working areas were simulated, as well as the modes of operation of protective pneumatic suits by female virologists. The results obtained are compared with the data of studies in which the individuals of the control group took part as subjects. Results. An analysis of the results of physiological studies indicates a systematic overheating of the body of the subjects in the process of performing labor operations in protective pneumatic suits. A number of characteristic changes in physiological parameters have been established for cases observed during human adaptation to heat. Conclusion. The data obtained indicate that the pneumatic suit, in the design of which the convective method of normalizing the human temperature homeostasis is realized, requires the development of special operating modes for the implementation of continuous technological or laboratory operations in it. A set of methods for evaluating the performance of personal protective equipment in terms of the thermal state of the human body was tested, which makes it possible to determine the degree of influence of environmental factors and the labor process on the functional state of employees in order to predict it and establish the optimal mode of work.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128871071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2021-4-66-71
D. V. Chebykin, Y. Khmelnitskaya, L.A. Ragozina, A.S. Borzykh
{"title":"EVALUATION OF THE EFFECTIVENESS OF DISTANT LEARNING TECHNOLOGIES USE IN THE EDUCATIONAL PROCESS AT NSMU","authors":"D. V. Chebykin, Y. Khmelnitskaya, L.A. Ragozina, A.S. Borzykh","doi":"10.31549/2541-8289-2021-4-66-71","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-4-66-71","url":null,"abstract":"","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124580517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-3-29-34
A. A. Glazkov, A. Kuznetsov, V. A. Kuznetsov, M. A. Gurkina, L. Kostina
Mastery of the intestine suture skills is one of the main competencies of a surgeon. Most of the available know¬ledge on the technical implementation of the intestinal suture is empirical, obtained over the years of the a¬uthor's practice, and transferred by him to the pages of his written work. In this regard, the study of such technical aspects of the implementation of an one-row intestinal suture is an important direction. The aim of the research is to perform a comparative evaluation of one-row extramucosal intestinal anastomoses realized with different stitch spacing. The study was carried out on preparations of the porcine small intestine after the formation of an one-row extramucosal intestinal anastomosis with different intervals between stitches. After that, an estimation of the tightness, execution time and number of stitches between study groups, was performed. The tightness was assessed by making a hydraulic test to determine the leakage pressure – the intraluminal pressure at which leakage occurred through the suture line. In the course of the study, the optimal interval between stitches was determined when applying an one-row intestinal anastomosis formed on the porcine small intestine.
{"title":"EXPERIMENTAL ESTIMATION OF THE OPTIMAL INTERVAL BETWEEN STITCHES OF AN ONE-ROW INTESTINAL SUTURE WITH REGARD TO TIGHTNESS","authors":"A. A. Glazkov, A. Kuznetsov, V. A. Kuznetsov, M. A. Gurkina, L. Kostina","doi":"10.31549/2541-8289-2022-6-3-29-34","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-3-29-34","url":null,"abstract":"Mastery of the intestine suture skills is one of the main competencies of a surgeon. Most of the available know¬ledge on the technical implementation of the intestinal suture is empirical, obtained over the years of the a¬uthor's practice, and transferred by him to the pages of his written work. In this regard, the study of such technical aspects of the implementation of an one-row intestinal suture is an important direction. The aim of the research is to perform a comparative evaluation of one-row extramucosal intestinal anastomoses realized with different stitch spacing. The study was carried out on preparations of the porcine small intestine after the formation of an one-row extramucosal intestinal anastomosis with different intervals between stitches. After that, an estimation of the tightness, execution time and number of stitches between study groups, was performed. The tightness was assessed by making a hydraulic test to determine the leakage pressure – the intraluminal pressure at which leakage occurred through the suture line. In the course of the study, the optimal interval between stitches was determined when applying an one-row intestinal anastomosis formed on the porcine small intestine.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122678391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2021-4-36-39
M. Pervuninskaya, L. Shchepankevich, I. Gribacheva, T. Popova, I. Novikova, E. Petrova, M. Shchepankevich
{"title":"RELATIONSHIP OF SERUM TNF-α LEVEL WITH ELECTRONEURO-PHYSIOLOGICAL PARAMETERS OF NERVOUS FIBER CONDUCTION VELOCITY IN PERIPHERAL DIABETIC NEUROPATHY","authors":"M. Pervuninskaya, L. Shchepankevich, I. Gribacheva, T. Popova, I. Novikova, E. Petrova, M. Shchepankevich","doi":"10.31549/2541-8289-2021-4-36-39","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-4-36-39","url":null,"abstract":"","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124124298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2023-7-2-24-31
A.G. Sidorkina, A. V. Yakimova, V. Mudrov
Chronic placental insufficiency is a serious problem for obstetricians and gynecologists worldwide, as it causes fetal hypoxia and growth retardation, and is also a risk factor for preeclampsia, which in turn negatively affects perinatal outcomes. In this regard, for proper routing and timely provision of medical care, it is necessary to competently use affordable and effective methods for diagnosing placental insufficiency. According to a number of authors, a high-risk group of pregnant women for the development of placental insufficiency can be distinguished on the basis of biochemical screening indicators of the first or second trimester, as well as Doppler ultrasound of the spiral arteries or the shape and echostructure of the placenta during ultrasound at 19–21 weeks. The aim of the study was to analyze the effectiveness of modern methods for diagnosing chronic placental insufficiency. A detailed systematic analysis of domestic and foreign literature on methods for diagnosing chronic placental insufficiency was carried out. The study used such information bases as eLibrary, PubMed, FIPS from the moment of its creation until March 2023. A total of 153 sources were analyzed by keywords, 45 of them were recognized as meeting the purpose of our study. Conclusion. Diagnosis of placental insufficiency should be based on an integrated approach, since only a combination of several methods gives a more accurate result.
{"title":"MODERN METHODS OF CHRONIC PLACENTAL INSUFFICIENCY DIAGNOSTICS","authors":"A.G. Sidorkina, A. V. Yakimova, V. Mudrov","doi":"10.31549/2541-8289-2023-7-2-24-31","DOIUrl":"https://doi.org/10.31549/2541-8289-2023-7-2-24-31","url":null,"abstract":"Chronic placental insufficiency is a serious problem for obstetricians and gynecologists worldwide, as it causes fetal hypoxia and growth retardation, and is also a risk factor for preeclampsia, which in turn negatively affects perinatal outcomes. In this regard, for proper routing and timely provision of medical care, it is necessary to competently use affordable and effective methods for diagnosing placental insufficiency. According to a number of authors, a high-risk group of pregnant women for the development of placental insufficiency can be distinguished on the basis of biochemical screening indicators of the first or second trimester, as well as Doppler ultrasound of the spiral arteries or the shape and echostructure of the placenta during ultrasound at 19–21 weeks. The aim of the study was to analyze the effectiveness of modern methods for diagnosing chronic placental insufficiency. A detailed systematic analysis of domestic and foreign literature on methods for diagnosing chronic placental insufficiency was carried out. The study used such information bases as eLibrary, PubMed, FIPS from the moment of its creation until March 2023. A total of 153 sources were analyzed by keywords, 45 of them were recognized as meeting the purpose of our study. Conclusion. Diagnosis of placental insufficiency should be based on an integrated approach, since only a combination of several methods gives a more accurate result.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126911224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-1-45-50
Yu.A. Shchekodko, Yu.V. Vizer, V. Drobyshev
The results of treatment of 60 patients with a verified diagnosis of ischemic stroke, acute period, with a motor deficit in the form of hemiparesis, with cognitive impairment, are presented; patients were distributed by random sampling into two groups: group 1 (30 people), the standard treatment was supplemented with a course of laser therapy, group 2 (30 people) received only the standard course of treatment. In patients, the effect of low-intensity laser radiation on the cognitive functions, short-term memory, attention, and mental abilities was studied. Efficiency was assessed using the MMSE scale, the Number Memory, Visual Memory Tests, and the method of finding numbers on Schulte Tables. It was found that the inclusion of low-level infrared laser radiation in a standard medical complex reduces the level of cognitive impairment by 2.3 times, increasing short-term memory by 1.6 times, attention by 2.2 times (p < 0.05). In the comparison group, the dynamics of these indicators is significantly lower. The inclusion of pulsed infrared low level laser therapy (LLLT) in the complex rehabilitation of patients with ACVA is a necessary link in neurorehabilitation measures as a method for compensating the impaired brain functions.
{"title":"APPLICATION OF PULSE INFRARED LOW-LEVEL LASER RADIATION IN COMPLEX TREATMENT OF PATIENTS WITH POST-STROKE COGNITIVE DISORDERS","authors":"Yu.A. Shchekodko, Yu.V. Vizer, V. Drobyshev","doi":"10.31549/2541-8289-2022-6-1-45-50","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-1-45-50","url":null,"abstract":"The results of treatment of 60 patients with a verified diagnosis of ischemic stroke, acute period, with a motor deficit in the form of hemiparesis, with cognitive impairment, are presented; patients were distributed by random sampling into two groups: group 1 (30 people), the standard treatment was supplemented with a course of laser therapy, group 2 (30 people) received only the standard course of treatment. In patients, the effect of low-intensity laser radiation on the cognitive functions, short-term memory, attention, and mental abilities was studied. Efficiency was assessed using the MMSE scale, the Number Memory, Visual Memory Tests, and the method of finding numbers on Schulte Tables. It was found that the inclusion of low-level infrared laser radiation in a standard medical complex reduces the level of cognitive impairment by 2.3 times, increasing short-term memory by 1.6 times, attention by 2.2 times (p < 0.05). In the comparison group, the dynamics of these indicators is significantly lower. The inclusion of pulsed infrared low level laser therapy (LLLT) in the complex rehabilitation of patients with ACVA is a necessary link in neurorehabilitation measures as a method for compensating the impaired brain functions.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116976825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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