Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2021-1-29-33
P. Zhelezny, S. P. Zhelezny, Yu.K. Zheleznaya, A. Zheleznaya, K. S. Shchelkunov, M. V. Nikolskaya, E. Piven
Long-term clinical observations on the treatment and rehabilitation of 117 children with tumors and tumor-like formations of the maxillofacial region are presented. To replace jaw defects, we used transplants preserved in various ways: frozen — in 48 patients, preserved in 0,5% formalin — in 7 patients, Kostma — in 7 pati¬ents, Deprotex — in 28 patients, Orgamax — in 27 patients. In the postoperative period, orthopedic and orthodontic rehabilitation of patients was carried out using removable and non-removable orthodontic appliances and dental implant systems. In the near term, no complications were revealed in 108 patients; consolidation of the graft with the bone bed occurred. 9 patients developed a purulent inflammatory process with allograft sequestration. The follow-ups of the patients showed that after transplantation, the allograft was gradually resorbed and replaced with a full-fledged organotypic regenerate within a period of 1,0 to 3 years. During the long-term up to 10 years follow-up, 92 patients (89,3 %) obtained good anatomical, functional and aesthetic results of rehabilitation, characterized by full restoration of the function of the dentition and facial aesthetics. In 11 patients (10,7 %), the results were satisfactory.
{"title":"PRESERVED ALLOPLASTIC MATERIAL IN TREATMENT OF TUMORS AND ODONTOGENIC CYSTS IN CHILDREN","authors":"P. Zhelezny, S. P. Zhelezny, Yu.K. Zheleznaya, A. Zheleznaya, K. S. Shchelkunov, M. V. Nikolskaya, E. Piven","doi":"10.31549/2541-8289-2021-1-29-33","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-1-29-33","url":null,"abstract":"Long-term clinical observations on the treatment and rehabilitation of 117 children with tumors and tumor-like formations of the maxillofacial region are presented. To replace jaw defects, we used transplants preserved in various ways: frozen — in 48 patients, preserved in 0,5% formalin — in 7 patients, Kostma — in 7 pati¬ents, Deprotex — in 28 patients, Orgamax — in 27 patients. In the postoperative period, orthopedic and orthodontic rehabilitation of patients was carried out using removable and non-removable orthodontic appliances and dental implant systems. In the near term, no complications were revealed in 108 patients; consolidation of the graft with the bone bed occurred. 9 patients developed a purulent inflammatory process with allograft sequestration. The follow-ups of the patients showed that after transplantation, the allograft was gradually resorbed and replaced with a full-fledged organotypic regenerate within a period of 1,0 to 3 years. During the long-term up to 10 years follow-up, 92 patients (89,3 %) obtained good anatomical, functional and aesthetic results of rehabilitation, characterized by full restoration of the function of the dentition and facial aesthetics. In 11 patients (10,7 %), the results were satisfactory.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116426129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2021-4-19-22
N. Yasakova, S. Mashak, O. V. Lisichenko, S. Zalavina, I.M. Samatova
{"title":"LYMPHOCYTE NUCLEUS AS POPULATION MONITORING TOOL FOR IDENTIFYING FETAL CHROMOSOME PATHOLOGY RISK GROUPS","authors":"N. Yasakova, S. Mashak, O. V. Lisichenko, S. Zalavina, I.M. Samatova","doi":"10.31549/2541-8289-2021-4-19-22","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-4-19-22","url":null,"abstract":"","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116579332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-2-43-47
Yu.K. Zheleznaya, S. P. Zhelezny, E. Piven
Introduction. Currently, there is no consensus in the literature about the incidence of secondary deformities of the dentitions and their age characteristics. Thus, the question of the prevalence and features of secondary dentoalveolar deformities and anomalies of the dental arches in different age groups is relevant. Aim of the research. To study the prevalence, nature, features of secondary dentoalveolar deformities and anomalies of the dentition in different age groups. Materials and methods. For our study, we selected patients of different age groups who consulted the orthopedic dentistry clinic of the FSBEI HE Novosibirsk State Medical University of the Ministry of Health of Russia, as well as the 2–5 year students of the Faculty of Dentistry. Group 1 — 150 students aged 18–27 years, group 2 — 130 patients aged 30–45 years, group 3 — 140 patients aged 46–60 years. Results. In group 1, 150 second-fifth year students of the Faculty of Dentistry of the Novosibirsk State Medical University, aged 18–27 years, were examined. In 13 of them, the teeth were intact. Signs of secondary dentition deformities in patients of the first group were observed in 63 (42%) students. In group 2, 130 patients aged 30 to 45 years were examined, in 5 patients the dentitions were intact. Signs of secondary deformities of dentitions in the examined group 2 were observed in 71 (56%) patients. In group 3, 140 patients aged 46 to 60 years were examined, 18 of them had intact dentitions. In 122 of them, partial loss of teeth was observed. Signs of secondary deformities of the dentition in the examined group 3 were observed in 55 people (40%). Conclusion. The study shows that secondary dentition deformities can be observed both with preserved dentition in cases of multiple carious lesions of the occlusal surfaces of the teeth, anatomically incorrect restoration of the occlusal surfaces of the crowns of chewing teeth, or their contact surfaces after filling, and with partial loss of teeth in all age groups.
{"title":"MORPHOFUNCTIONAL CHARACTERISTICS AND FEATURES OF SECONDARY DENTITION DEFORMITIES IN DIFFERENT AGE PERIODS","authors":"Yu.K. Zheleznaya, S. P. Zhelezny, E. Piven","doi":"10.31549/2541-8289-2022-6-2-43-47","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-2-43-47","url":null,"abstract":"Introduction. Currently, there is no consensus in the literature about the incidence of secondary deformities of the dentitions and their age characteristics. Thus, the question of the prevalence and features of secondary dentoalveolar deformities and anomalies of the dental arches in different age groups is relevant. Aim of the research. To study the prevalence, nature, features of secondary dentoalveolar deformities and anomalies of the dentition in different age groups. Materials and methods. For our study, we selected patients of different age groups who consulted the orthopedic dentistry clinic of the FSBEI HE Novosibirsk State Medical University of the Ministry of Health of Russia, as well as the 2–5 year students of the Faculty of Dentistry. Group 1 — 150 students aged 18–27 years, group 2 — 130 patients aged 30–45 years, group 3 — 140 patients aged 46–60 years. Results. In group 1, 150 second-fifth year students of the Faculty of Dentistry of the Novosibirsk State Medical University, aged 18–27 years, were examined. In 13 of them, the teeth were intact. Signs of secondary dentition deformities in patients of the first group were observed in 63 (42%) students. In group 2, 130 patients aged 30 to 45 years were examined, in 5 patients the dentitions were intact. Signs of secondary deformities of dentitions in the examined group 2 were observed in 71 (56%) patients. In group 3, 140 patients aged 46 to 60 years were examined, 18 of them had intact dentitions. In 122 of them, partial loss of teeth was observed. Signs of secondary deformities of the dentition in the examined group 3 were observed in 55 people (40%). Conclusion. The study shows that secondary dentition deformities can be observed both with preserved dentition in cases of multiple carious lesions of the occlusal surfaces of the teeth, anatomically incorrect restoration of the occlusal surfaces of the crowns of chewing teeth, or their contact surfaces after filling, and with partial loss of teeth in all age groups.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124094179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-2-17-21
E. V. Vostrikova, Yu.V. Panyushkina, A.K. Yakusheva, P. Pilipenko, M.A. Epalintseva
The article presents the analyzed anamnestic data of 118 patients with Parkinson's disease (40 men and 78 wo¬men). Patients were divided into groups according to the severity of the disease. The number of patients with the first degree of severity was 11 people, with the second — 36 people, with the third — 62 people, with the fourth degree — 9 people. According to the results of the study, it was found that non-motor symptoms were detected before the onset of motor symptoms of Parkinson's disease, and were also present in 100% of patients. Therefore, the understanding of the non-motor symptoms' pathology in this disease, and providing an early, accurate diagnosis and appropriate therapeutic approach at the prodromal stage, remains a major and challenging task in the treatment of Parkinson's disease.
{"title":"RETROSPECTIVE ASSESSMENT OF NON-MOTOR SYMPTOMS IN PARKINSON'S DISEASE","authors":"E. V. Vostrikova, Yu.V. Panyushkina, A.K. Yakusheva, P. Pilipenko, M.A. Epalintseva","doi":"10.31549/2541-8289-2022-6-2-17-21","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-2-17-21","url":null,"abstract":"The article presents the analyzed anamnestic data of 118 patients with Parkinson's disease (40 men and 78 wo¬men). Patients were divided into groups according to the severity of the disease. The number of patients with the first degree of severity was 11 people, with the second — 36 people, with the third — 62 people, with the fourth degree — 9 people. According to the results of the study, it was found that non-motor symptoms were detected before the onset of motor symptoms of Parkinson's disease, and were also present in 100% of patients. Therefore, the understanding of the non-motor symptoms' pathology in this disease, and providing an early, accurate diagnosis and appropriate therapeutic approach at the prodromal stage, remains a major and challenging task in the treatment of Parkinson's disease.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130371671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-1-18-22
G. S. Karpovich, I. V. Kuimova, A. Shestakov, T. V. Komissarova, M. A. Mihajlenko, Yu S Serova, Yu.S. Schekin
A prospective observation of 524 pediatric patients with laboratory-verified coronavirus infection was carried out. The main epidemiological data were analyzed, including the age structure, as well as the features of the clinical course of the disease. Most often, the clinical picture was dominated by symptoms of ARVI: hyperemia of the fauces — in 501 patients (95.6% of cases), while fever — in 412 (78.6%), and cough — in 89 (16.9%). The involvement of the gastrointestinal tract was manifested mainly by the symptoms of acute gastroenteritis, and was observed in 37.6% of cases, specifically diarrhea — 21.2%, vomiting — 16.5%, abdominal pain syndrome — 9.2%. These manifestations were significantly more frequently recorded in patients under one year, as well as children of the first three years of life (p ≤ 0.05).
{"title":"FEATURES OF THE NEW CORONAVIRUS INFECTION IN CHILDREN","authors":"G. S. Karpovich, I. V. Kuimova, A. Shestakov, T. V. Komissarova, M. A. Mihajlenko, Yu S Serova, Yu.S. Schekin","doi":"10.31549/2541-8289-2022-6-1-18-22","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-1-18-22","url":null,"abstract":"A prospective observation of 524 pediatric patients with laboratory-verified coronavirus infection was carried out. The main epidemiological data were analyzed, including the age structure, as well as the features of the clinical course of the disease. Most often, the clinical picture was dominated by symptoms of ARVI: hyperemia of the fauces — in 501 patients (95.6% of cases), while fever — in 412 (78.6%), and cough — in 89 (16.9%). The involvement of the gastrointestinal tract was manifested mainly by the symptoms of acute gastroenteritis, and was observed in 37.6% of cases, specifically diarrhea — 21.2%, vomiting — 16.5%, abdominal pain syndrome — 9.2%. These manifestations were significantly more frequently recorded in patients under one year, as well as children of the first three years of life (p ≤ 0.05).","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129327873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-3-16-21
D. Nepomnyashchikh, O. Postnikova, E. Vinogradova, E. E. Abramova, T. Suvorova, Y. Ovechkina, A. Tereshchenko
Introduction. The study of HCV + HBV mixed hepatitis is a serious problem due to the varied and more severe clinical picture compared to mono-infection, as well as the presence of seronegative variants of HBV infection. In addition, mixed infection is characterized by a more rapid progression of the pathological process to cirrhosis of the liver. The frequency of mixed infection detection has been increasing in recent years. Aim of the research. To study the structural and functional characteristics of the liver in mixed infection with HCV + HBV. Materials and methods. A comprehensive clinical and pathomorphological study of HCV + HBV mixed infection was carried out, which included 112 patients with markers of chronic hepatitis C and B. The age of the patients ranged from 16 to 69 years, 68 men and 44 women. In a clinical study, in addition to a detailed study of the anamnesis, blood biochemical parameters were tested: the level of aminotransferases (AlAT and AST), alkaline phosphatase (AP), gamma-glutamyl transpeptidase (GGTP), bilirubin, total protein, albumin, cholesterol, glucose. The system of hemostasis was studied: prothrombin time, prothrombin index; peripheral blood parameters were determined — hemoglobin, erythrocytes, platelets, leukocytes, ESR. Results. With a high activity of the infectious process, a tendency was found to increase in the surface density of the granular cytoplasmic reticulum in comparison with low activity indicators, which led to rather high ratio of organelles of the protein-synthesizing compartment and mitochondria to the cytoplasm of hepatocytes. In addition, with a high degree of mixed hepatitis activity, a slightly higher structural density of lipid inclusions and a lower volumetric density of cytoplasm devastation zones were found. In general, most of the main cytoplasmic organelles of hepatocytes in chronic HCV + HBV mixed infection had similar indicators of structural density, regardless of the process activity. Conclusion. Mixed HCV + HBV infection is characterized by phenotypic heterogeneity of the hepatocyte population associated with a variety of cytopathic effects caused by complex viral exposure. Hepatitis C RNA virus attacks predominantly cytoplasmic organelles while preserving the nucleus, hepatitis B DNA virus causes degradation of the nuclear compartment with the formation of a ring-shaped nucle cricoid that can be detected by light-optics. The combination of RNA and DNA hepatitis C and B viruses caused phenotypic heterogeneity of the hepatocyte population. Hepatitis C RNA virus caused the degradation of the cytoplasmic compartment of the cell, hepatitis B DNA virus, first of all, caused the modification of the nucleus.
{"title":"STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF THE LIVER IN MIXED HCV+HBV INFECTION","authors":"D. Nepomnyashchikh, O. Postnikova, E. Vinogradova, E. E. Abramova, T. Suvorova, Y. Ovechkina, A. Tereshchenko","doi":"10.31549/2541-8289-2022-6-3-16-21","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-3-16-21","url":null,"abstract":"Introduction. The study of HCV + HBV mixed hepatitis is a serious problem due to the varied and more severe clinical picture compared to mono-infection, as well as the presence of seronegative variants of HBV infection. In addition, mixed infection is characterized by a more rapid progression of the pathological process to cirrhosis of the liver. The frequency of mixed infection detection has been increasing in recent years. Aim of the research. To study the structural and functional characteristics of the liver in mixed infection with HCV + HBV. Materials and methods. A comprehensive clinical and pathomorphological study of HCV + HBV mixed infection was carried out, which included 112 patients with markers of chronic hepatitis C and B. The age of the patients ranged from 16 to 69 years, 68 men and 44 women. In a clinical study, in addition to a detailed study of the anamnesis, blood biochemical parameters were tested: the level of aminotransferases (AlAT and AST), alkaline phosphatase (AP), gamma-glutamyl transpeptidase (GGTP), bilirubin, total protein, albumin, cholesterol, glucose. The system of hemostasis was studied: prothrombin time, prothrombin index; peripheral blood parameters were determined — hemoglobin, erythrocytes, platelets, leukocytes, ESR. Results. With a high activity of the infectious process, a tendency was found to increase in the surface density of the granular cytoplasmic reticulum in comparison with low activity indicators, which led to rather high ratio of organelles of the protein-synthesizing compartment and mitochondria to the cytoplasm of hepatocytes. In addition, with a high degree of mixed hepatitis activity, a slightly higher structural density of lipid inclusions and a lower volumetric density of cytoplasm devastation zones were found. In general, most of the main cytoplasmic organelles of hepatocytes in chronic HCV + HBV mixed infection had similar indicators of structural density, regardless of the process activity. Conclusion. Mixed HCV + HBV infection is characterized by phenotypic heterogeneity of the hepatocyte population associated with a variety of cytopathic effects caused by complex viral exposure. Hepatitis C RNA virus attacks predominantly cytoplasmic organelles while preserving the nucleus, hepatitis B DNA virus causes degradation of the nuclear compartment with the formation of a ring-shaped nucle cricoid that can be detected by light-optics. The combination of RNA and DNA hepatitis C and B viruses caused phenotypic heterogeneity of the hepatocyte population. Hepatitis C RNA virus caused the degradation of the cytoplasmic compartment of the cell, hepatitis B DNA virus, first of all, caused the modification of the nucleus.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129536576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-4-51-54
R.I. Seliverstov, I. Samatov, D.N. Vostrikov, V. Dudin, D. Konovalov, E. Vereshchagin
This work is devoted to the topical issue of surgery and anesthesiology, namely, anesthesia and sedation in circulatory shock, in particular, burn shock. The aim of the study was to evaluate the effectiveness and safety of ketamine analgosedation in the acute period of severe burn injury. The pilot study included 9 adult patients aged 15–70 years having a severe burn injury with an area of >40% of the body surface, who were in the intensive care unit for more than 3 days. Intensive care in burn shock was carried out according to the accepted national clinical guidelines. Ketamine after a preliminary bolus (0.25–0.5 mg/kg) was administered through a perfusor (up to 25 mg/h). According to the totality of clinical and laboratory data (dynamics of lactate level, pH, BE, urination rate), shock was controled by the end of the second day from the moment of injury. The assessment of the level of sedation on the RASS scale in patient treated with ketamine showed on average at the level of 2 points during the observation period, the need for narcotic analgesics was limited by the need to perform surgical procedures. Side effects of the use of ketamine (intestinal paresis, vomiting, development of delirium) were not observed. Thus, we can conclude that ketamine analgosedation is safe and effective in burn shock.
{"title":"EFFECTIVENESS AND SAFETY OF KETAMINE ANALGOSEDATION IN THE ACUTE PERIOD OF SEVERE BURN INJURY","authors":"R.I. Seliverstov, I. Samatov, D.N. Vostrikov, V. Dudin, D. Konovalov, E. Vereshchagin","doi":"10.31549/2541-8289-2022-6-4-51-54","DOIUrl":"https://doi.org/10.31549/2541-8289-2022-6-4-51-54","url":null,"abstract":"This work is devoted to the topical issue of surgery and anesthesiology, namely, anesthesia and sedation in circulatory shock, in particular, burn shock. The aim of the study was to evaluate the effectiveness and safety of ketamine analgosedation in the acute period of severe burn injury. The pilot study included 9 adult patients aged 15–70 years having a severe burn injury with an area of >40% of the body surface, who were in the intensive care unit for more than 3 days. Intensive care in burn shock was carried out according to the accepted national clinical guidelines. Ketamine after a preliminary bolus (0.25–0.5 mg/kg) was administered through a perfusor (up to 25 mg/h). According to the totality of clinical and laboratory data (dynamics of lactate level, pH, BE, urination rate), shock was controled by the end of the second day from the moment of injury. The assessment of the level of sedation on the RASS scale in patient treated with ketamine showed on average at the level of 2 points during the observation period, the need for narcotic analgesics was limited by the need to perform surgical procedures. Side effects of the use of ketamine (intestinal paresis, vomiting, development of delirium) were not observed. Thus, we can conclude that ketamine analgosedation is safe and effective in burn shock.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"287 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115242825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2021-4-40-47
G. Usenko, N. P. Velichko, A. Uskov, L. Makarova, D.A. Makhmudyan
{"title":"DETERMINATION OF THE EFFECTIVENESS OF PERSONALIZED PHARMACOTHERAPY FOR ARTERIAL HYPERTENSION IN DIFFERENT CENTRAL NERVOUS SYSTEM ACTIVITY","authors":"G. Usenko, N. P. Velichko, A. Uskov, L. Makarova, D.A. Makhmudyan","doi":"10.31549/2541-8289-2021-4-40-47","DOIUrl":"https://doi.org/10.31549/2541-8289-2021-4-40-47","url":null,"abstract":"","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"1 S1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120837701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2023-7-2-60-67
A. V. Usova, T. M. Sokolova, K. Makarov, T. V. Kiseleva, E.N. Usolkina
From July 1, 2022, restrictions related to the spread of COVID-19 were lifted in Russia. But until now, according to experts, COVID-19 remains one of the most important medical problems for the global community. In 2023, 11 thousand people died from COVID-19 in the world, about 3 million were infected. There are cases known for complications from other organ systems in patients with COVID-19. However, in the general population, the course of COVID-19 is more severe in people with dyslipidaemia, obesity and hypertension. Often, these comorbidities are associated with polycystic ovary syndrome (PCOS). It is possible that women with PCOS will experience more severe clinical manifestations in the future. For 2020–2023 many women reported experiencing menstrual irregularities for the first time, which raised concerns about the impact of SARS-CoV-2 on reproductive function. There are currently insufficient clinical and statistically significant data to establish the causes of these disorders. This material is devoted to the analysis of the probable causes of menstrual irregularities in women with PCOS after a coronavirus infection: the possible direct effect of SARS-CoV-2 on the organs of the female reproductive system depending on the PCOS phenotype.
{"title":"PATHOGENETIC FEATURES OF THE INFLUENCE OF A PAST CORONAVIRUS INFECTION IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME","authors":"A. V. Usova, T. M. Sokolova, K. Makarov, T. V. Kiseleva, E.N. Usolkina","doi":"10.31549/2541-8289-2023-7-2-60-67","DOIUrl":"https://doi.org/10.31549/2541-8289-2023-7-2-60-67","url":null,"abstract":"From July 1, 2022, restrictions related to the spread of COVID-19 were lifted in Russia. But until now, according to experts, COVID-19 remains one of the most important medical problems for the global community. In 2023, 11 thousand people died from COVID-19 in the world, about 3 million were infected. There are cases known for complications from other organ systems in patients with COVID-19. However, in the general population, the course of COVID-19 is more severe in people with dyslipidaemia, obesity and hypertension. Often, these comorbidities are associated with polycystic ovary syndrome (PCOS). It is possible that women with PCOS will experience more severe clinical manifestations in the future. For 2020–2023 many women reported experiencing menstrual irregularities for the first time, which raised concerns about the impact of SARS-CoV-2 on reproductive function. There are currently insufficient clinical and statistically significant data to establish the causes of these disorders. This material is devoted to the analysis of the probable causes of menstrual irregularities in women with PCOS after a coronavirus infection: the possible direct effect of SARS-CoV-2 on the organs of the female reproductive system depending on the PCOS phenotype.","PeriodicalId":342613,"journal":{"name":"Sibirskij medicinskij vestnik","volume":"194 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122359609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.31549/2541-8289-2022-6-3-35-42
A. Yakovlev, S. Shilov, N. Yakovleva, E. Berezikova, R. S. Chernyshev, K. S. Sakhonchik, M. Kessler
Abstract. Obstructive sleep apnea syndrome (OSAS) is increasingly being considered as a factor associated with the development of nocturnal arrhythmias, as well as an increased risk of sudden cardiac death. The prevalence of OSA reaches 5-7% in the adult population. The prognostic role of pathological breathing patterns has not been sufficiently investigated, and therefore further study of the pathogenesis of arrhythmias for the subsequent intensification of therapeutic measures is promising. Aim of the Research. To study the prognostic significance of individual breathing parameters in different sleep phases for the development of atrial fibrillation and ventricular arrhythmias in patients with obstructive sleep apnea syndrome (OSAS) and chronic heart failure (CHF) with preserved ejection fraction (EF). Materials and methods. 86 men with moderate and severe OSAS (with an apnea/hypopnea index (AHI) >15 per hour) were examined. To diagnose OSAS, all patients underwent a polysomnographic study of night sleep. The severity of obstructive respiratory disorders during sleep was assessed by the apnea/hypopnea index for the total period of sleeping. Using polysomnography, we additionally investigated the following parameters of respiratory disturbances during the night sleep period: index of obstructive apnea/hypopnea selectively in REM sleep (AHIobsREM); index of respiratory distress syndrome for the entire period of sleep (IRDS); index of respiratory distress syndrome in the REM sleep phase (IRDS REM); average saturation per night; desaturation index for the total period of sleep; desaturation index in REM sleep. The observation period was 12 months, during which the presence of atrial fibrillation paroxysms lasting more than 30 s and the development of high-grade ventricular arrhythmias (III-V class according to Ryan) were assessed. Results. In the course of the study, a number of breathing parameters during the night time sleep (IAHobs, IAHobsREM, IRDS, IRDS REM) significantly correlated with the development of the studied cardiac arrhythmias. The most significant prognostic role has been stated for obstructive sleep apnea registered in the REM sleep phase. Conclusion. Breathing parameters during nighttime sleeping (IAHobs, IAHobs REM, IRDS, IRDS REM), which characterize the severity of OSAS are independent predictors of the development of paroxysmal atrial fibrillation and high-grade ventricular extrasystole in patients with OSAS and CHF with preserved EF. The results obtained make it possible to use these sleep parameters in the future in stratifying the risk of arrhythmias and determining treatment tactics in this cohort of patients.
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