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An evaluation of modelling of propagation using COMSOL for a singlemode-multimode-singlemode structure 利用COMSOL对单模-多模-单模结构的传播建模进行评价
Q4 Engineering Pub Date : 2026-01-26 DOI: 10.1016/j.measen.2026.101992
Thomas Freir , Arun Kumar Mallik , Yuliya Semenova , Gerald Farrell
This paper presents simulation models developed for investigating singlemode-multimode-singlemode (SMS) structures, with the intention of utilising precise nano-scale 3D printing to print the center-section of the structures modelled. The models allow the design of structures for use in SMS fiber sensors, replacing the silica fiber center-section structures commonly used, with 3D printed elements. The paper discusses the process of evaluating and validating COMSOL propagation models by comparison to existing reported results and proposes the use of SMS self-imaging length and the transmission spectra as useful metrics for model comparisons. Both 2D and 3D COMSOL models are developed, and both show good agreement in calculating self-imaging length with the other referenced models. In particular, the 3D model not only simulates the self-imaging length with high accuracy, but also shows good spectral agreement with the referenced models and an analytical calculation. In addition, results from previously published work by the group are used for comparison with the 3D COMSOL model.
本文介绍了为研究单模-多模-单模(SMS)结构而开发的仿真模型,目的是利用精确的纳米级3D打印来打印模型结构的中心部分。这些模型允许设计用于SMS光纤传感器的结构,用3D打印元件取代常用的二氧化硅纤维中心部分结构。本文通过与现有报告的结果进行比较,讨论了评估和验证COMSOL传播模型的过程,并提出使用SMS自成像长度和传输光谱作为模型比较的有用指标。建立了二维和三维COMSOL模型,两者在计算自成像长度方面与其他参考模型具有较好的一致性。特别是,三维模型不仅能较好地模拟自成像长度,而且与参考模型和解析计算结果具有较好的光谱一致性。此外,该小组先前发表的工作结果用于与3D COMSOL模型进行比较。
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引用次数: 0
Heterogeneous models with synergistic feature fusion for real-time apple recognition in robust apple harvesting robotics 基于协同特征融合的异构模型鲁棒苹果收获机器人实时苹果识别
Q4 Engineering Pub Date : 2026-01-16 DOI: 10.1016/j.measen.2026.101991
Changdong Yin , Jun Yao , Jianfei Xu , Zhou Xu , Luanfei Wan , Qiang Liu , Dongdong Ye
The advancement of agricultural automation intensifies demands for highly reliable visual recognition systems in orchard harvesting robots. However, it is difficult to achieve robust fruit detection for balancing high accuracy and real-time performance under complex orchard conditions with variable illumination, occlusions, and phenotypic diversity. This study proposes a collaborative framework integrating adaptive image processing with heterogeneous model inference. The methodology begins with Lab color space conversion to ensure illumination invariance. It further utilizes dual-threshold HSV segmentation for handling both red and green apples, alongside morphological optimization with elliptical structuring elements to address occlusion. A novel architecture allocates real-time screening to an embedded Random Forest (RF) classifier and precise localization to a host-based lightweight YOLOv5 model through fused color-morphological features. Experimental results demonstrate that morphological feature enhancement consistently outperforms color-based approaches across both models. The models with dual-feature input achieves optimal performance that the RF classifier attains accuracy of 83.35 %, while lightweight YOLOv5 reaches 98.90 % accuracy. Quantitative analysis reveals dual-feature fusion with color and morphology improving all metrics by over 3 % compared to non-enhanced baselines. Notably, the observed accuracy improvement exceeded the sum of gains from individual features, confirming a synergistic effect and proving the necessity of feature fusion. This work provides a computationally viable solution for reliable apple recognition in unstructured environments.
随着农业自动化的发展,对果园收获机器人的视觉识别系统的要求越来越高。然而,在光照、遮挡和表型多样性多变的复杂果园条件下,很难实现高精度和实时性的鲁棒水果检测。本研究提出了一种融合自适应图像处理和异构模型推理的协同框架。该方法从Lab色彩空间转换开始,以确保光照不变性。它进一步利用双阈值HSV分割来处理红苹果和青苹果,同时使用椭圆结构元素进行形态学优化来解决遮挡问题。一种新的架构将实时筛选分配给嵌入式随机森林(RF)分类器,并通过融合颜色形态特征将精确定位分配给基于主机的轻量级YOLOv5模型。实验结果表明,形态特征增强在两种模型中始终优于基于颜色的方法。在双特征输入模型中,射频分类器的准确率达到83.35 %,轻量级YOLOv5的准确率达到98.90 %。定量分析显示,与未增强的基线相比,颜色和形态的双特征融合使所有指标提高了3 %以上。值得注意的是,观察到的精度提高超过了单个特征的增益总和,证实了协同效应,证明了特征融合的必要性。这项工作为非结构化环境下可靠的苹果识别提供了一个计算上可行的解决方案。
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引用次数: 0
Editorial article (Special Issue): Measurement, control and security of systems for smart cities 社论文章(特刊):智慧城市系统的测量、控制与安全
Q4 Engineering Pub Date : 2026-01-13 DOI: 10.1016/j.measen.2026.101990
V.B. Murali Krishna , Hossein Fotouhi , Rajesh Cheruku , Abdul Wahid , Tien Anh Tran
The transition to truly smart cities demands more than layered technologies; it requires convergent intelligence that unifies physical sensing, adaptive control, and ethical security. This editorial paper brief about the special issue entitled “Measurement, Control and Security of Systems for Smart Cities”. As smart cities are among the most active research areas, the call for papers for this special issue, “VSI: Systems for Smart Cities” attracted a wide range of manuscripts spanning multiple disciplines, including Computer Science, Electrical and Electronics Engineering, Communication Engineering, Civil Engineering, Mechanical Engineering, Urban Construction, Artificial Intelligence and Machine Learning, Cybersecurity, and Renewable Energy etc. Notably, authors from 16 different countries, including Algeria, Chile, China, Egypt, England, Ethiopia, India, Iran, Jordan, Kosovo, Nigeria, Portugal, Saudi Arabia and United Arab Emirates have contributed their research articles. In this editorial, we synthesize insights from all 30 published articles to present a holistic vision of next-generation urban ecosystems. Together, these works span renewable energy, structural health, healthcare, transportation, noise pollution, public space, and data security, these works collectively redefine what it means to build intelligent infrastructure that is sustainable, equitable, resilient, and trustworthy. We organize these advances around three interwoven pillars: (1) Measurement for Awareness, (2) Control for Adaptation, and (3) Security and Ethics for Trust-and demonstrate how fractional-order controllers, lightweight crack detectors, edge-based triage systems, multimodal transport models, and secure data-mining frameworks all contribute to a human-centered urban future. This synthesis serves as both a technical roadmap and a philosophical compass for the responsible evolution of smart cities.
向真正的智慧城市过渡需要的不仅仅是分层技术;它需要融合智能,将物理感知、自适应控制和道德安全统一起来。这篇社论简要介绍了题为“智能城市系统的测量、控制和安全”的特刊。由于智慧城市是最活跃的研究领域之一,本期《VSI: Systems for smart cities》特刊的论文征稿吸引了广泛的稿件,涉及多个学科,包括计算机科学、电气与电子工程、通信工程、土木工程、机械工程、城市建设、人工智能与机器学习、网络安全、可再生能源等。值得注意的是,来自阿尔及利亚、智利、中国、埃及、英国、埃塞俄比亚、印度、伊朗、约旦、科索沃、尼日利亚、葡萄牙、沙特阿拉伯和阿拉伯联合酋长国等16个不同国家的作者贡献了他们的研究文章。在这篇社论中,我们综合了所有30篇已发表文章的见解,以呈现下一代城市生态系统的整体愿景。这些作品涵盖了可再生能源、结构健康、医疗保健、交通运输、噪音污染、公共空间和数据安全,这些作品共同重新定义了建设可持续、公平、有弹性和值得信赖的智能基础设施的意义。我们围绕三个相互交织的支柱来组织这些进展:(1)意识测量,(2)适应控制,(3)信任安全和道德,并展示分数阶控制器、轻量级裂缝检测器、基于边缘的分类系统、多式联运模式和安全数据挖掘框架如何为以人为中心的城市未来做出贡献。这种综合既可以作为技术路线图,也可以作为智慧城市负责任发展的哲学指南针。
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引用次数: 0
Effect of deposition time on microstructure and optoelectronic properties of lead selenide thin films 沉积时间对硒化铅薄膜微观结构及光电性能的影响
Q4 Engineering Pub Date : 2026-01-05 DOI: 10.1016/j.measen.2026.101983
Yanyan Zheng , Zhibo Yang , Xiaoshui Zhang , Wei Li , Ruiqin Gu , Hongjun Ren
Lead selenide (PbSe) thin films are promising materials for mid-infrared photodetection owing to their narrow bandgap (0.2–0.4 eV), high carrier mobility, and tunable optoelectronic properties. However, current fabrication processes for PbSe detectors still face challenges in producing large-area, high-performance photosensitive films, which has hindered the commercialization of large-format, high-performance PbSe infrared imaging systems. In the chemical bath deposition (CBD) of PbSe thin films, deposition time is a critical parameter influencing film thickness, crystallinity, grain size, compactness, surface morphology, and stoichiometry. This study systematically investigates the role of deposition time in tailoring the morphology, crystallinity, and photoresponse of CBD-prepared PbSe films. Experimentally, the PbSe film deposited for 4.5 h exhibited a dark resistance of 3.078 MΩ and a photoresponse ratio of 20.4 %. In comparison, films deposited for 3 h and 5.5 h showed higher dark resistances of 7.396 MΩ and 6.84 MΩ, respectively. XRD and SEM characterization revealed a U-shaped relationship between deposition time and the optoelectronic properties of the PbSe films. Therefore, systematic optimization of deposition time is a key step toward obtaining high-performance PbSe films. This work provides valuable insights for the application of PbSe materials in infrared detection.
硒化铅(PbSe)薄膜由于其窄带隙(0.2-0.4 eV)、高载流子迁移率和可调谐的光电特性而成为中红外光电探测的重要材料。然而,目前的PbSe探测器的制造工艺仍然面临着生产大面积、高性能光敏薄膜的挑战,这阻碍了大画幅、高性能PbSe红外成像系统的商业化。在PbSe薄膜的化学浴沉积(CBD)中,沉积时间是影响薄膜厚度、结晶度、晶粒尺寸、致密性、表面形貌和化学计量学的关键参数。本研究系统地研究了沉积时间对cbd制备的PbSe薄膜的形貌、结晶度和光响应的影响。实验结果表明,沉积时间为4.5 h的PbSe薄膜耐暗性为3.078 MΩ,光响应比为20.4 %。相比之下,沉积时间为3 h和5.5 h的膜的抗暗性更高,分别为7.396 MΩ和6.84 MΩ。XRD和SEM表征表明,沉积时间与PbSe薄膜的光电性能呈u型关系。因此,系统地优化沉积时间是获得高性能PbSe薄膜的关键步骤。这项工作为PbSe材料在红外探测中的应用提供了有价值的见解。
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引用次数: 0
UAV-based object detection model for smart surveillance using deep neural network 基于深度神经网络的无人机智能监控目标检测模型
Q4 Engineering Pub Date : 2025-12-25 DOI: 10.1016/j.measen.2025.101982
Gyanendra Kumar , Sur Singh Rawat , Jyoti Gautam , Ayodeji Olalekan Salau
Unmanned aerial vehicles (UAVs) have become indispensable in both civilian and military domains, enabling applications such as smart surveillance, environmental monitoring, and search-and-rescue operations. However, effective object detection in UAV imagery remains challenging due to the small size of targets, high object density, frequent occlusions, and complex backgrounds resulting from varying altitudes and viewpoints. Existing algorithms, such as You Only Look Once (YOLO) v5, exhibit limited accuracy in detecting targets in UAV images. To address these challenges, this study proposes an enhanced YOLOv5-based detection model. The model incorporates an optimized detection module with three prediction heads for multi-scale bounding box predictions. Additionally, self-attention mechanisms and a Convolutional Block Attention Module (CBAM) are integrated to focus on salient regions and mitigate the impact of occlusions. Furthermore, we introduce a ConvELU layer, which replaces the default SiLU activation with the Exponential Linear Unit (ELU). This modified ConvELU layer is applied to the backbone, neck, and head components, effectively improving the model's feature extraction capabilities. Experimental results of the VisDrone dataset demonstrate that the proposed model achieves a precision of 95.1 %, a recall of 86.3 %, and a mean Average Precision (mAP) of 91.6 %, outperforming the standard YOLOv5 and other state-of-the-art detectors.
无人驾驶飞行器(uav)在民用和军事领域都是不可或缺的,可以实现智能监视、环境监测和搜救行动等应用。然而,由于目标尺寸小、目标密度高、频繁遮挡和不同高度和视点导致的复杂背景,在无人机图像中有效的目标检测仍然具有挑战性。现有的算法,例如You Only Look Once (YOLO) v5,在UAV图像中探测目标表现出有限的精度。为了应对这些挑战,本研究提出了一种增强的基于yolov5的检测模型。该模型结合了一个优化的检测模块,具有三个预测头,用于多尺度边界框预测。此外,自我注意机制和卷积块注意模块(CBAM)相结合,专注于突出区域,减轻闭塞的影响。此外,我们引入了一个ConvELU层,它用指数线性单元(ELU)取代了默认的SiLU激活。将改进后的ConvELU层应用于脊柱、颈部和头部部件,有效提高了模型的特征提取能力。VisDrone数据集的实验结果表明,该模型的准确率为95.1%,召回率为86.3%,平均平均精度(mAP)为91.6%,优于标准的YOLOv5和其他最先进的检测器。
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引用次数: 0
A review of electrical reflectometry applications: State of the art, positioning, bibliometric analysis and future directions 回顾电反射计的应用:现状、定位、文献计量分析和未来方向
Q4 Engineering Pub Date : 2025-12-24 DOI: 10.1016/j.measen.2025.101981
Wafa Ben Hassen, Mariem Slimani, Fabrice Auzanneau
Electrical reflectometry is widely utilized for cable diagnosis to detect and locate both hard faults (such as open or short circuits) and soft faults (such as chafing, bending radius issues, pinching, etc.). It offers the advantage of using only one end of the cable under test to inject an electromagnetic wave and simultaneously record reflected echoes at each impedance discontinuity. Then, the analysis of these echoes makes it possible to obtain information about that discontinuity. Reflectometry is valued for its simplicity of deployment, sensitivity to electrical parameter variations in the propagation medium, and accuracy in fault location. These attributes make it a promising method in various domains such as Structural Health Monitoring (SHM), complex load monitoring, environmental monitoring, etc., especially considering that the cable used for reflectometry signal propagation can also function as a sensor. In this context, this paper aims to provide an in-depth review of potential applications of electrical reflectometry beyond cable diagnostics and compare it with other established methods (e.g., acoustic, fiber optics, etc.). A bibliometric analysis is presented in this paper, which, to the best of our knowledge, is the first of its kind in the reflectometry-related literature.
电反射法被广泛用于电缆诊断,以检测和定位硬故障(如开路或短路)和软故障(如摩擦、弯曲半径问题、夹紧等)。它的优点是只使用被测电缆的一端注入电磁波,同时记录每个阻抗不连续处的反射回波。然后,对这些回波进行分析,就有可能获得有关该不连续的信息。反射计的价值在于其部署简单,对传播介质中的电气参数变化敏感,以及故障定位的准确性。这些特性使得它在结构健康监测(SHM)、复杂载荷监测、环境监测等各个领域都有很好的应用前景,特别是考虑到用于反射信号传播的电缆也可以作为传感器。在此背景下,本文旨在深入回顾电反射法在电缆诊断之外的潜在应用,并将其与其他已建立的方法(如声学、光纤等)进行比较。本文提出了文献计量学分析,据我们所知,这是反射计量学相关文献中的第一个。
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引用次数: 0
SPR sensors enhanced by nanomaterials for monitoring heavy metal ions in water: A mathematical modeling 纳米材料增强的SPR传感器监测水中重金属离子:数学模型
Q4 Engineering Pub Date : 2025-12-12 DOI: 10.1016/j.measen.2025.101980
Talia Tene , Cristina Estefanía Ramos Araujo , Natalia Alexandra Pérez Londo , Lorenzo S. Caputi , Salvatore Straface , Cristian Vacacela Gomez
Surface plasmon resonance (SPR) sensors enable label-free readout of refractive-index (RI) changes at metal–dielectric interfaces and are promising for on-site water monitoring, whereas ICP-MS/AAS lack portability. We model prism-coupled SPR using a CaF2 prism and a Cu/Si3N4 stack overlaid with graphene-family films at 633 nm. Four overlayers—graphene, semiconducting single-wall carbon nanotubes (s-SWCNTs), graphene oxide (GO), and reduced graphene oxide (rGO)—are compared via a transfer-matrix approach. Metrics include resonance-angle shift (Δθ), angular sensitivity (S), detection accuracy (DA), quality factor (QF), figure of merit (FoM), limit of detection (LoD), and a combined sensitivity factor (CSF) in deionized water and heavy-metal solutions. Simulations reveal a dual-regime design: rGO maximizes raw sensitivity (318.21° RIU−1 for Pb2+) with LoD ≈ 1.57 × 10−5 RIU, whereas GO provides the sharpest resonances (QF ≈ 195 RIU−1; DA ≈ 0.64); graphene and s-SWCNTs are intermediate. Electric-field profiles yield a penetration depth of ≈50–52 nm with the 2D layer at the field maximum. We justify the CaF2/Cu choice, map trade-offs across 2D films, and outline functionalization, scalable fabrication, stability, and miniaturization, alongside microfluidic, multi-wavelength, and AI-assisted validation toward meeting WHO/EPA guidelines.
表面等离子体共振(SPR)传感器能够在金属-介电界面上无标签地读出折射率(RI)变化,有望用于现场水质监测,而ICP-MS/AAS缺乏便携性。我们使用CaF2棱镜和覆盖石墨烯家族薄膜的Cu/Si3N4堆叠在633 nm处模拟棱镜耦合SPR。四种覆盖层——石墨烯、半导体单壁碳纳米管(s-SWCNTs)、氧化石墨烯(GO)和还原氧化石墨烯(rGO)——通过转移矩阵方法进行了比较。指标包括去离子水和重金属溶液中的共振角位移(Δθ)、角灵敏度(S)、检测精度(DA)、质量因子(QF)、性能值(FoM)、检测限(LoD)和综合灵敏度因子(CSF)。模拟结果显示了一种双机制设计:rGO的原始灵敏度最高(Pb2+为318.21°RIU−1),LoD ≈ 1.57 × 10−5 RIU,而GO提供最强烈的共振(QF ≈ 195 RIU−1;DA ≈ 0.64);石墨烯和s-SWCNTs是中间体。电场剖面产生的穿透深度≈50-52 nm,其中2D层在电场最大时。我们证明了CaF2/Cu的选择,绘制了2D薄膜之间的权衡图,并概述了功能化、可扩展制造、稳定性和小型化,以及微流体、多波长和人工智能辅助验证,以满足WHO/EPA指南。
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引用次数: 0
Paddy leaf disease identification and K-means cluster segmentation using multi-class SVM techniques 基于多类支持向量机的水稻叶片病害识别与K-means聚类分割
Q4 Engineering Pub Date : 2025-11-13 DOI: 10.1016/j.measen.2025.101979
S. Amosedinakaran , P. Anitha , R. Kannan , K. Karthikeyan , S. Suresh , A. Bhuvanesh
The economy of any country is significantly dependent on agricultural yield. A major concern for all countries is facing leaf diseases in agriculture due to bacteria or infections that decrease the yield. To prevent the spreading of leaf diseases, early detection and diagnosis are essential. The plant disease detection technique has been utilized to avoid a reduction in yield percentage. Image processing-based solutions have been quite essential in practice and must be quick, automated, affordable, and precise. The multi-class support vector machine (multi-class SVM) technique has been adopted for this study. This technique extracts information from given samples and provides exceptional results that would help identify and classify the diseases in the plants. Paddy leaf has been adopted for study. This study is focuses clearly on four key components: (i) the research problem early and accurate detection of paddy leaf diseases using image processing; (ii) the methodological approach multi-class SVM classification combined with K-means++ segmentation and complementary descriptors such as color statistics, HOG, and GLCM; (iii) the results achieving an average recognition accuracy of 93 % and peak performance of 96 % with 17 % faster execution compared to traditional methods; and (iv) the practical implications demonstrating the method's potential for efficient, low-cost disease diagnosis in agricultural environments. This strategy has a lot of promise to help with early plant disease diagnosis and enhance crop management techniques. Its implementation has the potential to address a significant gap in agricultural disease management and contribute meaningfully to improving global food security.
任何国家的经济都严重依赖农业产量。所有国家关注的一个主要问题是,由于细菌或感染导致的农业叶片病害会降低产量。为了防止叶病的蔓延,早期发现和诊断是必不可少的。利用植物病害检测技术,避免了产量百分比的下降。基于图像处理的解决方案在实践中非常重要,并且必须快速、自动化、经济实惠和精确。本研究采用多类支持向量机(multi-class support vector machine,简称multi-class SVM)技术。该技术从给定的样品中提取信息,并提供有助于识别和分类植物疾病的特殊结果。以水稻叶片为研究对象。本研究明确了四个关键组成部分:(1)利用图像处理技术早期准确检测水稻叶片病害的研究问题;(ii)结合k -means++分割和互补描述符(如颜色统计、HOG和GLCM)的多类SVM分类方法;(iii)与传统方法相比,平均识别准确率达到93%,峰值性能达到96%,执行速度提高17%;(iv)证明该方法在农业环境中具有高效、低成本疾病诊断潜力的实际意义。这一策略在帮助早期植物病害诊断和提高作物管理技术方面具有很大的前景。它的实施有可能解决农业疾病管理方面的重大差距,并为改善全球粮食安全作出有意义的贡献。
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引用次数: 0
Can Excel® be used for gauge R&R study based on the analysis of variance (Anova)? 能否将Excel®用于基于方差分析(Anova)的计量R&R研究?
Q4 Engineering Pub Date : 2025-11-07 DOI: 10.1016/j.measen.2025.101978
Alban Petitjean, Olivier Musset
The Analysis of Variance (Anova) method, alongside the range method, is widely used to conduct Gauge Repeatability and Reproducibility (Gauge R&R) studies for measurement systems. While Anova provides more precise and robust statistical insights compared to the range-based approach, it is often perceived as more complex due to the necessity of calculating sum of squares, mean squares, and performing F-tests. Furthermore, this method can lead to misleading conclusions if the results—especially residuals—are not thoroughly and correctly analyzed. Despite its analytical complexity, the Anova method can be effectively implemented using spreadsheet tools such as Excel®. Excel® offers a flexible and accessible environment to perform rapid recalculations when input data are modified. In this paper, we demonstrate how to conduct a Gauge R&R study using the Anova approach within Excel®. The dual objective of this work is (i) to provide a user-friendly implementation within Excel®, and (ii) to enable rigorous and accurate interpretation of the statistical results produced.
方差分析(Anova)方法与量程法一起被广泛用于测量系统的测量重复性和再现性(Gauge R&;R)研究。虽然与基于范围的方法相比,方差分析提供了更精确、更稳健的统计见解,但由于需要计算平方和、均方和执行f检验,它通常被认为更复杂。此外,如果对结果(特别是残差)分析不彻底、不正确,这种方法可能会导致误导性结论。尽管其分析的复杂性,方差分析方法可以有效地实现使用电子表格工具,如Excel®。Excel®提供了一个灵活和可访问的环境,以执行输入数据修改时快速重新计算。在本文中,我们演示了如何在Excel®中使用方差分析方法进行测量R&;R研究。这项工作的双重目标是(i)在Excel®中提供一个用户友好的实现,以及(ii)对产生的统计结果进行严格和准确的解释。
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引用次数: 0
Sub-second response algorithm for wearable glucose sensors: normalized slope-based calibration and microvolumes differential compensation measurements 可穿戴式葡萄糖传感器的亚秒响应算法:标准化的基于坡度的校准和微体积差分补偿测量
Q4 Engineering Pub Date : 2025-11-03 DOI: 10.1016/j.measen.2025.101977
V. Esposito, E. Sciurti, A. Calogiuri, D. Bellisario, L. Velardi, F. Casino, L. Blasi, L. Francioso
Traditional methods of blood glucose monitoring are invasive and can cause anxiety, pain and infection, resulting in poor patient compliance. Sweat-based glucose sensing has emerged as a promising non-invasive alternative, but the significantly lower glucose concentrations (10–100 times lower than in blood) pose a challenge for sensor sensitivity and operation. Here, we present different measurement protocols for enzymatic electrochemical glucose sensors with enhanced sensitivity and sub-second response calibration algorithm. The resulting amperometric response accurately reflects glucose concentration, demonstrating the sensor's potential for non-invasive monitoring of glucose in sweat. To enhance the reliability of the measurements and mitigate the variability among sensors arising from differences in sweat composition and secretion, a post-measurement protocol was developed. This protocol exploits a Response Correction Factor (RCF) calculated from the specific sensitivity of each sensor. This approach compensates for variability among different sensors reducing the standard deviation, thereby improving calibration accuracy (R2 = 0.995 vs. R2 = 0.822 without correction) allowing the prevention of phenomena related to enzyme inactivation or allogeneic reactions that may affect individual sensors in Continuous Glucose Monitoring (CGM) systems. An in-depth analysis was also conducted using sample microvolumes (20 μL), the typical amount of sweat available in wearable devices, to study thin-layer chronoamperometry response. To enhance the linearity of the sensor response, a differential compensation algorithm based on the slope of the response curve was adopted, employing a sensor without enzyme as a reference. This measurement method enhanced the dynamic range of slope values from 0.0085 μA/s to 0.0125 μA/s. The experimental results identified in a reliable way three operational regions: physiological (60–110 μM), warning values (110–160 μM) and alert/risk (>160 μM). The proposed strategies increase the robustness and applicability of sweat-based glucose monitoring for real-world applications.
传统的血糖监测方法具有侵入性,可引起焦虑、疼痛和感染,导致患者依从性差。基于汗液的葡萄糖传感已经成为一种很有前途的非侵入性替代方法,但明显较低的葡萄糖浓度(比血液低10-100倍)对传感器的灵敏度和操作构成了挑战。在这里,我们提出了不同的测量方案的酶电化学葡萄糖传感器具有增强的灵敏度和亚秒响应校准算法。由此产生的电流响应准确地反映了葡萄糖浓度,证明了传感器在无创监测汗液中葡萄糖的潜力。为了提高测量的可靠性,并减轻因汗液成分和分泌差异而引起的传感器之间的可变性,制定了测量后协议。该协议利用响应校正因子(RCF)从每个传感器的特定灵敏度计算。这种方法补偿了不同传感器之间的可变性,减少了标准偏差,从而提高了校准精度(R2 = 0.995 vs. R2 = 0.822,未经校正),从而防止了与酶失活或异体反应相关的现象,这些现象可能会影响连续血糖监测(CGM)系统中的单个传感器。采用样品微体积(20 μL)(可穿戴设备的典型汗液量)进行深入分析,研究薄层计时电流响应。为了提高传感器响应的线性度,采用基于响应曲线斜率的微分补偿算法,以无酶传感器为参考。该测量方法将斜率值的动态范围从0.0085 μA/s提高到0.0125 μA/s。实验结果可靠地确定了三个操作区域:生理(60-110 μM)、预警值(110-160 μM)和预警/风险(>160 μM)。所提出的策略增加了基于汗液的葡萄糖监测在实际应用中的鲁棒性和适用性。
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引用次数: 0
期刊
Measurement Sensors
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