Endocrine and Metabolic Science最新文献

{"title":"Effects of a novel weight-loss combination product containing orlistat and resveratrol on obesity: A multicenter randomized controlled study (EC-FIT)","authors":"Khin Maung Win ,&nbsp;Tint Swe Latt ,&nbsp;Aung Hlaing Bwa ,&nbsp;Khin Maung Aye ,&nbsp;Kyaw Soe Tun ,&nbsp;Hardik Gandhi","doi":"10.1016/j.endmts.2025.100218","DOIUrl":"10.1016/j.endmts.2025.100218","url":null,"abstract":"<div><h3>Background</h3><div>Orlistat, a weight loss medication, is often less effective due to poor adherence to the dietary and exercise recommendations. However, its effectiveness is often compromised by poor adherence to recommended lifestyle changes and side effects like steatorrhea. Combining orlistat with resveratrol may enhance weight loss and offer additional metabolic benefits.</div></div><div><h3>Objective</h3><div>This study evaluated the real-world efficacy and safety of orlistat combined with resveratrol versus orlistat alone in overweight or obese individuals in Myanmar.</div></div><div><h3>Method</h3><div>Obese adults (BMI ≥ 25 kg/m²) were randomized into two groups for a 12-week study. The Orlistat (O) group received orlistat 120 mg three times daily, while the Orlistat &amp; Resveratrol (O-R) group took orlistat 120 mg plus resveratrol 100 mg thrice daily. Primary outcome measured was weight change; secondary outcomes included Total Cholesterol, LDL-cholesterol, Blood pressure, HbA1c, alanine transaminase (ALT), controlled attenuation parameter (CAP), Liver stiffness, and Total Body Fat. Adverse events were also recorded.</div></div><div><h3>Result</h3><div>The O-R group lost more weight (−3.31 kg, 95 % CI: 2.36–5.04, <em>p</em> &lt; 0.001) than the O group (−2.92 kg, 95 % CI: −2.6442–4.5471, <em>p</em> &lt; 0.001). Additionally, the O-R group showed greater reductions in total body fat (−4.93 %), diastolic blood pressure (78.38 mmHg vs 75.93 mmHg; 95 % CI: 0.4473–4.4707, <em>p</em> &lt; 0.05), and CAP score (276.62 dB/m vs 253.16 dB/m; 95 % CI: 8.46–38.85, <em>p</em> &lt; 0.05). Significant weight loss in the O-R group was observed in obese patients with steatosis (S1–S3) or fibrosis (F2–F4), and in diabetic patients, particularly those with a BMI ≥30 (−2.79 kg vs −1.04 kg, <em>p</em> &lt; 0.05) and steatosis (−2.17 kg vs −0.44 kg, <em>p</em> &lt; 0.05). Steatorrhea occurred in both groups, while diarrhoea was noted only in the O group.</div></div><div><h3>Conclusion</h3><div>Addition of resveratrol to orlistat provides synergistic benefits to weight loss with additional benefit in terms of reducing total body fat and diastolic BP. These benefits were also apparent in subgroup of patients with diabetes suffering from obesity or steatosis.</div><div>Trial registration number: ISRCTN10642495.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleeve gastrectomy and pancreatic omentoplasty decrease insulin resistance: Impact on pro-inflammatory and anti-inflammatory cytokine gene expression","authors":"Abdul Mughni ,&nbsp;Reno Rudiman ,&nbsp;Tjokorda Gde Dalem Pemayun ,&nbsp;Bella Renata ,&nbsp;Endang Mahati ,&nbsp;Suharyo Hadisaputro ,&nbsp;Ignatius Riwanto","doi":"10.1016/j.endmts.2025.100217","DOIUrl":"10.1016/j.endmts.2025.100217","url":null,"abstract":"<div><h3>Background</h3><div>Chronic systemic inflammation in obesity impairs insulin sensitivity and contributes to insulin resistance. Laparoscopic sleeve gastrectomy results in substantial weight loss and improved diabetic status, although 25 % of patients do not achieve optimal insulin production due to pancreatic fat accumulation. Addressing pancreatic inflammation is essential for better glycemic control. Pancreatic omentoplasty may enhance vascularization and reduce inflammation. This study examines the effects of sleeve gastrectomy and pancreatic omentoplasty on insulin resistance by analyzing the gene expression of pro- and anti-inflammatory cytokines and their correlation with HOMA-IR values.</div></div><div><h3>Method</h3><div>An experimental study with post-test only control design was conducted with obese and type 2 diabetes mellitus (T2DM) rat subjects which underwent sleeve gastrectomy treatment (SG), a combination of pancreatic omentoplasty and sleeve gastrectomy (SG + PO), without any intervention or a positive control group (+control), and rats which were neither obese nor T2DM or a negative control group (−control). On day 10 after surgery, blood samples from the rats were taken to assess blood glucose and insulin level in order to calculate HOMA-IR. Then, the pancreatic tissue of each rats was taken to extract the mRNA of TNF-α, IL-1, IL-6, and IL-10 by reverse-transcription polymerase chain reaction.</div></div><div><h3>Result</h3><div>The expression of the pro-inflammatory cytokine TNF-α in the SG + PO group was lower compared to the SG group (<em>p</em> = 0.008), IL-1 in the SG + PO group was lower than in the SG group (<em>p</em> = 0.043), and IL-6 in the SG + PO group was lower compared to the control group (<em>p</em> = 0.001). In contrast, the anti-inflammatory cytokine IL-10 was higher in the SG + PO group compared to the SG group (<em>p</em> = 0.001). Additionally, HOMA-IR in the SG + PO group was lower compared to the SG group (p = 0.001).</div></div><div><h3>Conclusion</h3><div>The combination of sleeve gastrectomy and pancreatic omentoplasty reduces pro-inflammatory cytokints (TNF-α, IL-1, IL-6) and increases anti-inflammatory cytokine IL-10, compared to sleeve gastrectomy alone. It also significantly lowers insulin resistance (HOMA-IR), suggesting that the combined procedure improves insulin sensitivity and glycemic control, cytokine modulation.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between abdominal obesity and hyperuricaemia in individuals with type 2 diabetes mellitus: A case–control study","authors":"Ruihao Liu ,&nbsp;Yuanyuan Zhang ,&nbsp;Zhiming Hu ,&nbsp;Huijian Deng","doi":"10.1016/j.endmts.2025.100216","DOIUrl":"10.1016/j.endmts.2025.100216","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is associated with hyperuricaemia in the general population; however, that relationship has not been studied in detail in patients with type 2 diabetes mellitus (T2DM), nor has the possibility of sex differences in that relationship been investigated.</div></div><div><h3>Methods</h3><div>A retrospective case–control study was conducted. We explored the correlation between abdominal obesity and hyperuricaemia among 315 Chinese patients with T2DM aged 27–64 years who had received community health services between January 2021 and August 2022. Abdominal obesity was defined as a waist circumference ≥ 85.0 cm in females and ≥ 90.0 cm in males. Hyperuricaemia was defined as a serum uric acid level &gt; 7.0 mg/dL in males and postmenopausal females, &gt; 6.0 mg/dL in premenopausal females, or receiving medical treatment for hyperuricaemia. The male and female groups were each separately divided into two additional groups: those with abdominal obesity and those without abdominal obesity. Odds ratios (OR) and 95 % confidence intervals (CI) for the risk of hyperuricaemia were calculated using a logistic regression model.</div></div><div><h3>Results</h3><div>The prevalence of hyperuricaemia in male and female patients in the study area was 42.86 % and 28.00 %, respectively. Abdominal obesity (<em>OR</em> = 3.369, <em>95</em> <em>% CI</em> = 1.031–11.009, <em>P</em> value &lt;0.05) was the determinant variable for hyperuricaemia among male patients with T2DM but not among female patients. There was no significant difference in the prevalence of hyperuricaemia between male or female T2DM patients with different body mass index (BMI) levels.</div></div><div><h3>Conclusions</h3><div>Our study revealed that abdominal obesity, but not overall obesity, was associated with an increased risk of hyperuricaemia in male patients with T2DM. Neither abdominal obesity nor overall obesity was associated with an increased risk of hyperuricaemia in female patients with T2DM. Abdominal obesity is a more effective predictor of hyperuricaemia than overall obesity is in male patients with T2DM.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer, deuterium, and gut microbes: A novel perspective","authors":"Stephanie Seneff ,&nbsp;Anthony M. Kyriakopoulos","doi":"10.1016/j.endmts.2025.100215","DOIUrl":"10.1016/j.endmts.2025.100215","url":null,"abstract":"<div><div>Deuterium is a natural isotope of hydrogen, containing a neutron as well as a proton, which makes it twice as heavy as hydrogen. In this paper, we develop a theoretical argument that human metabolism strives to minimize the amount of deuterium in mitochondrial water, because it causes a stutter in ATPase pumps, introducing excess reactive oxygen species and reduced ATP production. Gut microbes produce hydrogen gas that is 80 % depleted in deuterium (deupleted). This gas is recycled into organic matter that supplies deupleted nutrients to the host, such as acetate, butyrate, and choline. Mitochondrial dysfunction is associated with many chronic diseases, most notably, cancer. Dehydrogenases, through proton tunneling, typically have a high deuterium kinetic isotope effect (KIE), and they supply deupleted protons to the ATPase pumps via NADH (nicotinamide adenine dinucleotide) synthesis. We propose that a tumor may arise as a consequence of mitochondrial stress in immune cells due to excess deuterium, and that the tumor microenvironment can support immune cell recovery from mitochondrial dysfunction. Cancer cells alter protein expression to support deuterium sequestration through membrane-bound vesicular ATPase, and they release deupleted nutrients, mainly lactate, into the extracellular milieu and the circulation. Deuterium depleted water (DDW) has been shown to prolong life in cancer patients. An organic high fat diet rich in B vitamins, especially niacin, riboflavin, and folate, augmented with natural prebiotics and probiotics, supports deuterium homeostasis and likely protects from cancer.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sirtuin, irisin, and vitamin D as predictors of diabetes mellitus with uncontrolled glycemia in Indonesian patients","authors":"Elly Herwana ,&nbsp;Yenny ,&nbsp;Alvina ,&nbsp;Kurniasari ,&nbsp;Clarissa Asha Febinia ,&nbsp;Pusparini","doi":"10.1016/j.endmts.2024.100214","DOIUrl":"10.1016/j.endmts.2024.100214","url":null,"abstract":"<div><div>The incidence of type 2 diabetes mellitus is increasing in developing countries, including Indonesia. Insulin resistance is a significant contributor to elevated blood glucose levels in type-2 diabetes patients. Low levels of serum sirtuin-1, irisin, and vitamin D have been linked to insulin resistance. This study aimed to identify risk factors that could predict uncontrolled glycemia and insulin resistance in Indonesian type-2 diabetes patients. We conducted a cross-sectional study with 73 adults from South Jakarta, Indonesia, in which we examined type-2 diabetes risk factors and biomarkers, including sex, age, body mass index, waist circumference, waist–to–hip ratio, fasting blood glucose (FBG) levels, fasting insulin, sirtuin-1, irisin, and vitamin D levels. The subjects were categorized into two groups based on their glycated hemoglobin (HbA1c) level and homeostatic model assessment for insulin resistance (HOMA-IR) index to assess glycemic control and insulin resistance, respectively. We compared risk factor profiles between groups and analyzed multivariate relationships with logistic regression. Our findings revealed that 54 % of the subjects had uncontrolled glycemia, whereas only 11 % had insulin resistance. There was a significant association between uncontrolled glycemia and reduced sirtuin-1 levels (odds ratio = 4.07; <em>p</em> = 0.03), which was confirmed in the multivariate analysis (beta = 5.41, <em>p</em> = 0.014) along with FBG (beta = 36.88, <em>p</em> = 0.001). Irisin showed a marginal association with insulin resistance in both univariate (odds ratio = 0.12; <em>p</em> = 0.027) and multivariate analyses (beta = 0.09; <em>p</em> = 0.049). In conclusion, sirtuin-1, in addition to FBG, is a potential marker for assessing glycemic control in type-2 diabetes patients.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing diabetes risk assessment through Bayesian networks: An in-depth study on the Pima Indian population","authors":"Xiaoling Liang ,&nbsp;Wenhao Song ,&nbsp;Weibing Yang ,&nbsp;Zhenhua Yue","doi":"10.1016/j.endmts.2024.100212","DOIUrl":"10.1016/j.endmts.2024.100212","url":null,"abstract":"<div><div>This study aimed to enhance diabetes mellitus (DM) risk assessment using Bayesian Networks (BNs) and explore their unique capability for risk inference within the Pima Indian population. The primary goal was to move beyond traditional binary DM classification and instead focus on a comprehensive estimation of disease risk, considering the complex interplay of risk factors. The study employed the well-established Pima Indian dataset to assess diabetes risk. BNs were utilized to model the intricate interdependencies among risk factors and provide a nuanced understanding of disease susceptibility, including Bayesian risk reasoning for inferring probabilities of unknown nodes. Logistic regression (LR) was employed as a comparative benchmark to underscore BNs' advantages. BNs demonstrated a distinct advantage over conventional LR, as evidenced by their superior AUC value on the training dataset. This outcome highlighted BNs' capacity to capture intricate variable interactions and perform risk inference, thus enhancing predictive accuracy. The study also showcased BNs' resilience to real-world data distribution nuances, despite a slight decline in AUC on the testing dataset. This research substantiates the potency of BNs in augmenting diabetes risk assessment. The integration of BNs illuminates complex interplay among variables and enables a comprehensive risk evaluation, leveraging Bayesian risk reasoning for nuanced assessments. The study underscores the pivotal role of BNs in elucidating intricate causal relationships, contributing to the broader discourse on leveraging Bayesian methods for health risk prediction. The findings underscore the potential for personalized healthcare interventions aimed at managing DM and mitigating its societal burden.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiopathogenesis and management updates on the comorbidity depression – Diabetes: A review of literature","authors":"Roland Muyisa Muhindo","doi":"10.1016/j.endmts.2024.100213","DOIUrl":"10.1016/j.endmts.2024.100213","url":null,"abstract":"<div><div>Comorbidity depression – diabetes is a common condition and is often associated with complications and high mortality. Both of these conditions are due to genetic predispositions associated with environmental factors. Many mechanisms explain the occurrence of this comorbidity. Two are the most studied: the involvement of oxidative stress and chronic inflammation. For the management, the management of depression in diabetics does not consist of a simple combination of antidepressants with antidiabetics but global management including medicinal and non-drug means. New drugs targeting NRH2 are in development. They would act on comorbidity depression – diabetes at the same time.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the synergistic effects of gamma-glutamyl transferase with homocysteine, ferritin, and uric acid in patients with type II diabetes mellitus","authors":"Simin Shirvani ,&nbsp;Masomeh Halvaeezade ,&nbsp;Maryam Avazzade ,&nbsp;Morteza Golbashirzadeh ,&nbsp;Atousa Moradzadegan","doi":"10.1016/j.endmts.2024.100211","DOIUrl":"10.1016/j.endmts.2024.100211","url":null,"abstract":"<div><h3>Background and aim</h3><div>Type 2 diabetes mellitus (T2DM) is a growing public health concern, with oxidative stress implicated in its onset and progression. This study evaluates the synergistic effects of gamma-glutamyl transferase (γ-GT) as a marker of oxidative stress with homocysteine (Hcy), uric acid (UA), and ferritin in T2DM patients compared to healthy individuals.</div></div><div><h3>Material and methods</h3><div>This case-control study included 200 participants, with 100 T2DM patients and 100 age- and sex-matched healthy individuals from the Ahvaz Pasteur pathology laboratory. Serum glucose and ferritin levels were measured using the Cobas E411 autoanalyzer (ECL method), and γ-GT, Hcy, and UA levels were measured using the Pentra C400 analyzer (photometric method). Data were analyzed using XLSTAT and SPSS software.</div></div><div><h3>Results</h3><div>A significant correlation was found between fasting blood sugar (FBS) and 2-h postprandial (2hpp) glucose levels with ferritin serum levels (<em>P</em> &lt; 0.001, <em>r</em> = 0.419 and <em>P</em> = 0.002, <em>r</em> = 0.290, respectively), indicating ferritin's role in T2DM development. Ferritin levels were significantly related to γ-GT levels (<em>P</em> &lt; 0.001, <em>r</em> = 0.359) and correlated with Hcy (<em>P</em> = 0.001, <em>r</em> = 0.336) and UA (<em>P</em> = 0.02, <em>r</em> = 0.218) in T2DM patients.</div></div><div><h3>Conclusion</h3><div>This study highlights the role of oxidative stress and the synergistic effects of γ-GT and ferritin in T2DM development, underscoring their potential as cost-effective and widely available markers for predicting T2DM in clinical practice. Unlike previous studies, which focused individually on oxidative stress markers, this research uniquely combines γ-GT with Hcy, UA, and ferritin, providing a comprehensive assessment of oxidative stress in T2DM patients.</div></div><div><h3>Main points</h3><div><ul><li><span>1.</span><span><div><strong>Role of Oxidative Stress in T2DM</strong>: The study investigates the role of oxidative stress markers, particularly gamma-glutamyl transferase (γ-GT) and ferritin, in the development of Type 2 diabetes mellitus (T2DM).</div></span></li><li><span>2.</span><span><div><strong>Correlation with Other Biomarkers</strong>: Significant correlations were found between ferritin levels and other biomarkers such as fasting blood sugar (FBS), 2-hour postprandial (2hpp) glucose, homocysteine (Hcy), and uric acid (UA) in T2DM patients.</div></span></li><li><span>3.</span><span><div><strong>Predictive Value in Clinical Practice</strong>: The study highlights the potential of γ-GT and ferritin as cost-effective and widely available assays for predicting T2DM in clinical practice</div></span></li></ul></div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing nanoscale innovations for enhanced healing of diabetic foot ulcers","authors":"Marwan Al-Raeei","doi":"10.1016/j.endmts.2024.100210","DOIUrl":"10.1016/j.endmts.2024.100210","url":null,"abstract":"<div><div>In this article, we explore the transformative potential of nanomaterials in managing diabetic foot ulcers (DFUs), a significant complication affecting millions of individuals globally. These chronic wounds pose substantial challenges in diabetes care, often leading to severe infections and amputations. We emphasize that traditional treatment modalities are insufficient, thereby necessitating innovative approaches. Nanomaterials, characterized by unique physicochemical properties at the nanoscale, enhance biological interactions, facilitating accelerated healing, and targeted drug delivery. We discuss various applications of nanomaterials, from their intrinsic antimicrobial capabilities—exemplified by silver nanoparticles—to their role in promoting cell proliferation and migration critical for effective tissue repair. Furthermore, we highlight their capacity for controlled drug release and improved oxygen supply, both vital for optimal wound healing. This comprehensive review delineates the steps required for integrating nanomaterials into clinical practice, stressing the importance of thorough research, formulation, regulatory approval, and personalized treatment strategies. By leveraging these advanced materials, we assert that significant advancements in DFU management can be achieved, improving patient outcomes and quality of life. Our findings underscore the necessity for ongoing research aimed at optimizing the application of nanomaterials in wound care, thereby paving the way for innovative, evidence-based practices that address the complex challenges inherent in diabetic foot ulcer treatment.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic and meta-analyses of diabetic retinopathy and its care-related predictors after diabetic mellitus treatment initiation in Ethiopia","authors":"Aboma Motuma ,&nbsp;Abdi Birhanu ,&nbsp;Lemma Demissie Regassa ,&nbsp;Sina Tolera ,&nbsp;Alemayehu Deressa ,&nbsp;Usmael Jibro ,&nbsp;Mulugeta Gamachu ,&nbsp;Moti Tolera ,&nbsp;Adera Debella ,&nbsp;Bikila Balis ,&nbsp;Addis Eyeberu ,&nbsp;Fethia Mohammed ,&nbsp;Ibsa Mussa","doi":"10.1016/j.endmts.2024.100209","DOIUrl":"10.1016/j.endmts.2024.100209","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic retinopathy (DR) is a major complication of diabetes mellitus (DM) that affects the blood vessels of the retina and cause vision loss and blindness. DR is a major public health problem worldwide, especially in low-and middle-income countries where access to screening and treatment is limited. Although Ethiopia has implemented a strategic plan targeting DM care improvement to reduce complications from 2020 to 2025, retinopathy is a severe complication among DM patients. Therefore, this study aimed to assess diabetic retinopathy among DM patients after treatment initiation in Ethiopia from 2020/2021 to 2024/2025 after the strategy was implemented.</div></div><div><h3>Method</h3><div>Using the preferred reporting items for systematic reviews and meta-analysis guidelines, we systematically reviewed and meta-analyzed articles from Scholar, PubMed, Excerpta Medical Database (EMBASE), Cochrane Library, and MESH Medline. The data were extracted using Microsoft Excel and analyzed using STATA version 17. The pooled risk of new diabetic retinopathy among diabetes patients who started DM treatment was estimated. To minimize the effect of heterogeneity, subgroup analysis was performed by geographical region and year of publication (between 2020 and 2023). Publication bias was detected using a funnel plot, with P &lt; 0.05 assumed to indicate potential publication bias. The I² test was used to assess the heterogeneity of the studies.</div></div><div><h3>Results</h3><div>The pooled risk of diabetic retinopathy among treated DM patients was 25.43% (95% CI: 18.1, 32.7) from 2020 to 2023. The incidence of DR was 28.6% in the South Nation, Nationalities, and People (SNNPs) region, followed by Oromia (31.35%) and Amhara (22.93%). Care-related factors such as receiving a combination of DM medication (AOR=0.62, 95% CI: 0.47–0.82, n=3), having good glycemic control (AOR=0.24, 95% CI; 0.17–0.33, n=4), and comorbidities with hypertension (AOR=1.39, 95% CI; 1.17–1.87, n=4) were predictors of diabetic retinopathy development among DM patients at follow-up.</div></div><div><h3>Conclusion</h3><div>Even if the studies could not be combined due to high heterogeneity, they demonstrated that diabetic complications, particularly DR, are still high after starting treatment among DM patients in Ethiopia. Care-related factors such as treatment modalities, glycemic control levels, and comorbidities with hypertension should be appropriately screened and managed to reduce the burden of DR among DM patients receiving follow-up care in Ethiopia. Moreover, Ethiopia should evaluate the already set plan implementation status to achieve the target set by 2025.</div></div>","PeriodicalId":34427,"journal":{"name":"Endocrine and Metabolic Science","volume":"17 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}