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2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)最新文献

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An energy efficient inverter based readout circuit for capacitive sensor 一种基于逆变器的电容式传感器读出电路
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679705
T. Nguyen, P. Häfliger
This paper presents a high energy efficient, parasitic free and low complex readout integrated circuit for capacitive sensors. A very low power consumption is achieved by replacing a power hungry operation amplifier by a subthreshold inverter instead in a switched capacitor amplifier(SC-amp) and reducing the supply voltage of all digital circuits in the system. A fast respond finite gain compensation method is utilized to reduce the gain error of the SC-amp and increase the energy efficiency of the readout circuit. A two-step auto calibration is applied to eliminate the offset from nonideal effects of the SC-amp and comparator delay. The readout system is implemented and simulated in TSMC 90 nm CMOS technology. With supply voltage of 1 V, simulation shows that the circuit can achieve 10.4 bit resolution while consuming only 3 μW during 640 μs conversion time. The digital output code has little sensitivity to temperature variation.
提出了一种高能效、无寄生、低复杂读出的电容式传感器集成电路。通过在开关电容放大器(SC-amp)中用亚阈值逆变器取代耗电运算放大器,并降低系统中所有数字电路的供电电压,实现了非常低的功耗。采用快速响应的有限增益补偿方法,减小了sc放大器的增益误差,提高了读出电路的能量效率。两步自动校准应用于消除sc放大器和比较器延迟的非理想影响的偏移。采用台积电90nm CMOS技术对读出系统进行了仿真。仿真结果表明,在电源电压为1 V时,电路在640 μs转换时间内,功耗仅为3 μW,可实现10.4 bit的分辨率。数字输出码对温度变化的敏感性很小。
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引用次数: 13
Efficient scene preparation and downscaling prior to stimulation in retinal prosthesis 视网膜假体刺激前的有效场景准备和缩小尺寸
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679669
W. Al-Atabany, P. Degenaar
Retinal prostheses are moving towards providing a return to some functional vision for those with the Retinitis Pigmentosa disease. Optoelectronic/optogenetic retinal prosthesis holds particular promise. As the various techniques are unlikely to return perfect vision in the first instance, we need to explore how best to present the visual scene. The key task is to restore mobility and scene recognition to the patients. Therefore, some form of reduction for the visual information should be applied before transfer to the retina. In particular, scene segmentation can reduce unimportant textures, thus increasing the contrast of the key features and objects. Based on the thermal characteristics of objects, in this paper we present a new processing platform to just transfer important objects segmented using mixed visible-infra red imaging. With this new segmentation approach, complex objects are still distinguishable even with low effective resolution.
视网膜假体正朝着为色素性视网膜炎患者提供一些功能视力的方向发展。光电/光基因视网膜假体具有特殊的前景。由于各种技术都不可能在第一时间返回完美的视觉效果,我们需要探索如何最好地呈现视觉场景。关键任务是恢复患者的活动能力和场景识别能力。因此,在将视觉信息转移到视网膜之前,应该对其进行某种形式的还原。特别是场景分割可以减少不重要的纹理,从而增加关键特征和物体的对比度。基于物体的热特性,本文提出了一种新的处理平台,可以对可见光-红外混合成像分割出的重要物体进行仅仅转移。利用这种新的分割方法,即使在较低的有效分辨率下,仍然可以区分复杂的目标。
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引用次数: 3
Skin insertion mechanisms of microneedle-based dry electrodes for physiological signal monitoring 用于生理信号监测的微针干电极皮肤插入机制
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679642
C. O’Mahony, F. Pini, Liza Vereschagina, A. Blake, J. O'Brien, C. Webster, P. Galvin, K. McCarthy
This paper assesses the skin penetration mechanisms and insertion forces of a microneedle-based dry electrode for physiological signal monitoring. Using force-displacement measurements, it is shown that these ultrasharp microneedles, fabricated using a bulk micromachining process and which have tip radii as low as 50 nm, penetrate in-vivo human skin smoothly and without a measurable rupturing action. Skin staining techniques have been used to demonstrate that 95% penetration is achieved at just 20 mN per needle. These very low penetration forces facilitate the design of safe microneedle arrays and remove the requirement for applicator devices. Wearable electrode prototypes have been assembled using these arrays, and electrocardiography (ECG) recordings have been carried out to verify the functionality of the technique.
本文研究了一种用于生理信号监测的微针干电极的皮肤渗透机制和插入力。通过力-位移测量,研究人员发现,这些尖端半径低至50纳米的超锋利微针可以平滑地穿透人体皮肤,并且不会产生可测量的破裂作用。已使用皮肤染色技术证明,每针仅20 mN即可达到95%的穿透力。这些非常低的穿透力有助于设计安全的微针阵列,并消除了对应用装置的要求。使用这些阵列组装了可穿戴电极原型,并进行了心电图(ECG)记录以验证该技术的功能。
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引用次数: 3
Towards automatic sleep staging via Cross-Recurrence Rate of EEG and ECG activity 通过脑电图和心电图活动的交叉复发率实现自动睡眠分期
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679673
N. Nicolaou, J. Georgiou
This paper investigates the non-linear dynamic relationship between electroencephalogram (EEG) and electrocardiogram (ECG) signals during sleep. These relationships were studied with Cross-Recurrence Rate (CRR), a non-linear measure that studies the recurrence of the phase space trajectories of dynamical systems. Data from 10 subjects during sleep were obtained from the MIT-BIH Polysomnographic database and the CRR between ECG and EEG signals was estimated. The investigations revealed strong coupling relationships between ECG and EEG that varied according to the underlying sleep stage. From a physiological perspective, the findings indicate an increase in EEG and ECG during deep sleep, while also indicating the feasibility of potential CRR application for automatic sleep staging.
研究了睡眠时脑电图(EEG)和心电图(ECG)信号之间的非线性动态关系。这些关系用交叉递归率(cross - recurrent Rate, CRR)来研究,交叉递归率是研究动力系统相空间轨迹递归的非线性度量。从MIT-BIH多导睡眠图数据库中获取10名受试者的睡眠数据,并估计心电和脑电图信号之间的CRR。调查显示,心电图和脑电图之间的耦合关系很强,根据潜在的睡眠阶段而变化。从生理学角度来看,研究结果表明深度睡眠时脑电图和心电图增加,同时也表明CRR潜在应用于自动睡眠分期的可行性。
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引用次数: 1
Non-contact ECG employing signal compensation 采用信号补偿的非接触心电
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679639
G. Peng, M. Bocko
Non-contact ECG monitoring is an attractive option in a number of applications such as long-term health monitoring where traditional adhesive ECG sensors would cause skin irritation and require frequent replacement. Also, integrating ECG sensors into furniture, automobile seats and elsewhere in the environment will enable non-invasive sensing of cardiac signals. Subject-electrode relative motion causes spurious signals and significant signal distortion. The ECG signal of interest as well as static charge and electromagnetic interference are modulated by changes in the coupling capacitance between the electrodes and subject, which leads to significant distortions. The focus of this paper is the development of a non-contacting ECG sensing system including the electrodes, interface electronics and a signal-processing unit that work together to address this issue. The subject-to-electrode distance is continuously monitored by a secondary sensing circuit that uses the ECG electrodes themselves which serve as both the primary ECG readout and the secondary subject-to-electrode distance readout. Finally, the experimental results show the secondary readout signal can be used to compensate the motion-related gain variations of the primary ECG monitoring circuit as well as the additive interference by motion events.
在许多应用中,非接触式ECG监测是一种有吸引力的选择,例如长期健康监测,传统的粘接式ECG传感器会引起皮肤刺激,需要经常更换。此外,将ECG传感器集成到家具、汽车座椅和环境中的其他地方,将使心脏信号的非侵入性感知成为可能。被测电极的相对运动会产生杂散信号和明显的信号失真。被测电极与被测对象之间耦合电容的变化会调制被测对象感兴趣的心电信号以及静电和电磁干扰,从而导致显著的畸变。本文的重点是开发一种非接触式心电传感系统,该系统包括电极、接口电子器件和信号处理单元,它们共同工作以解决这一问题。受试者与电极之间的距离由一个二级传感电路连续监测,该电路使用ECG电极本身作为主ECG读数和次级受试者与电极之间的距离读数。实验结果表明,二次读出信号可用于补偿主心电监测电路的运动相关增益变化以及运动事件的加性干扰。
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引用次数: 10
Fabrication and packaging of a fully implantable biosensor array 全植入式生物传感器阵列的制造与封装
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679665
C. Baj-Rossi, Enver G. Kilinc, S. Ghoreishizadeh, Daniele Casarino, T. R. Jost, C. Dehollain, F. Grassi, L. Pastorino, G. Micheli, S. Carrara
In this work, we showed the realization of a fully-implantable device that integrates a microfabricated sensing platform , a coil for power and data transmission and integrated circuits. We described a device intended to test the biocompatibility of the materials used for the microfabrication. Therefore, electronics measurements for data communication and remote powering will be reported in another article [1]. To ensure biocompatibility an epoxy enhanced polyurethane membrane was used to cover the device. We proved through an in-vitro characterization that the membrane was capable to retain enzyme activity up to 35 days. After 30 days of implant in mice, in-vivo experiments proved that the membrane promotes the integration of the sensor with the surrounding tissue, as demonstrated by the low inflammation level at the implant site.
在这项工作中,我们展示了一个完全可植入的设备的实现,该设备集成了一个微加工传感平台,一个用于电力和数据传输的线圈以及集成电路。我们描述了一种用于测试用于微加工的材料的生物相容性的设备。因此,数据通信和远程供电的电子测量将在另一篇文章中报道。为了确保生物相容性,使用环氧增强聚氨酯膜覆盖装置。我们通过体外表征证明,膜能够保持酶活性长达35天。在小鼠体内植入30天后,体内实验证明,该膜促进了传感器与周围组织的整合,正如植入部位的低炎症水平所证明的那样。
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引用次数: 7
Non-contact ECG recording system with real time capacitance measurement for motion artifact reduction 具有实时电容测量的非接触式心电记录系统,可减少运动伪影
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679657
T. Torfs, R. Yazicioglu
A system for non-contact ECG recording is proposed that measures the real time electrode-body capacitance concurrently with the ECG. The realized system has been bench-validated to accurately measure capacitance and initial measurements on the human body are presented that indicate a correlation between electrode motion artifacts in the ECG and the real time capacitive impedance signal. This indicates that the additional capacitance information can potentially be used to reduce electrode motion artifacts, one of the main problems in ECG recording.
提出了一种非接触式心电记录系统,该系统可在测量心电的同时实时测量电极-体电容。所实现的系统已经过台架验证,可以准确测量电容,并在人体上进行了初步测量,表明心电中电极运动伪影与实时电容阻抗信号之间存在相关性。这表明额外的电容信息可以潜在地用于减少电极运动伪影,这是ECG记录的主要问题之一。
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引用次数: 3
Multiplexed detection of waterborne pathogens with an array of microfluidic integrated high-sensitivity organic photodiodes 微流控集成高灵敏度有机光电二极管阵列多路检测水传播病原体
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679650
Nuno M. M. Pires, T. Dong
It is reported a high-throughput microfluidic system integrating organic photodetectors based on poly(2,7-carbazole) semiconducting polymer. The system reported here showed detection limits of 105-106 cells/mL for the chemiluminescence detection of two bacterial cells. The detection of viral particles as low as 10-4 μg/mL was also shown. High specificity and ability to perform multiplexed analysis in an integrated lab-on-a-chip device was demonstrated.
报道了一种基于聚(2,7-咔唑)半导体聚合物集成有机光电探测器的高通量微流控系统。本系统对两种细菌细胞的化学发光检测的检出限为105-106个细胞/mL。病毒颗粒低至10-4 μg/mL。高专一性和能力,执行多路分析在一个集成的实验室芯片上的设备被证明。
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引用次数: 5
A highly energy-efficient compressed sensing encoder with robust subthreshold clockless pipeline for wireless BANs 一种高效节能的压缩感知编码器,具有鲁棒的亚阈值无时钟流水线
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679662
Yi Li, Xu Cheng, Yicheng Zhang, Weijing Shi, Jun Han, Xiaoyang Zeng
Compressed sensing is considered as a novel energy and bandwidth solution for wireless body area networks. In subthreshold operation, the conventional parallel structure is less energy-efficient than pipeline due to the low-frequency signals and the serious leakage energy. In this paper, we present a clockless pipeline compressed sensing encoder for highly energy-efficient purpose. Quasi-Delay-Insensitive circuits are introduced in the memory and the adder for improving the subthreshold robustness. The zero value detector in control units reduces the costs of computing power consumption and period. The full customized design is implemented in TSMC 65nm LP CMOS technology. Post-layout simulation results show that it can operate in the subthreshold supply voltage of 200mV. The most energy-efficient point is achieved as 109.8pJ at 300 mV. The max operation frequency ranges from 3KHz to 690KHz at 200mV to 600mV. For a fixed-throughput ECG signal, it improves 9.5× energy-efficiency compared with the parallel structure at 300mV and realizes minimum power consumption of 0.23μW at 200mV.
压缩感知被认为是无线体域网络中一种新的能量和带宽解决方案。在亚阈值工况下,传统并联结构由于信号频率低、能量泄漏严重,节能效果不如管道。本文提出了一种高效节能的无时钟管道压缩感知编码器。在存储器和加法器中引入准延迟不敏感电路,提高了亚阈值鲁棒性。控制单元中的零值检测器降低了计算功耗和周期成本。全定制设计采用台积电65nm LP CMOS技术实现。布置图后的仿真结果表明,该电路可以在200mV的亚阈值电压下工作。最节能的点是在300毫伏时达到109.8pJ。在200mV至600mV时,最大工作频率范围为3KHz至690KHz。对于固定吞吐量的心电信号,该结构在300mV时的能效比并联结构提高9.5倍,在200mV时实现了0.23μW的最小功耗。
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引用次数: 1
A CMOS MedRadio-band low-power integer-N cascaded phase-locked loop for implantable medical SOCs 一种用于植入式医疗soc的CMOS medradio波段低功耗整n级联锁相环
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679695
Yu-Yu Liao, Wei-Ming Chen, Chung-Yu Wu
In this paper, a low power integer-N cascaded Phase-locked loop (PLL) is proposed to provide the carrier signal and clock signals for a SOC with MedRadio-band transceiver, ADC, DSP, and 13.56-MHz wireless power supply. In the proposed cascaded PLL, the first PLL provides the sampling clocks while the second PLL provides the carrier clock. Furthermore, the 13.56-MHz signal from the receiving coil of the wireless power transmission system is utilized as the input reference signal. Ring-based voltage controlled oscillator (VCO) is designed to minimize both power consumption and chip area. The proposed cascaded PLL is designed and implemented in 0.18-μm CMOS technology. The measured phase noise is -79 dBc/Hz at 100 kHz offset under 402.9 MHz. The measured power consumptions are 0.28 mW in the first PLL and 0.46mW in the second PLL with a 1.8V supply voltage. The proposed cascaded PLL has low power dissipation, small chip area, and no off-chip components or crystal oscillator. It is suitable for the integration with implantable medical SOCs.
本文提出了一种低功耗整数n级联锁相环(PLL),为带有medradio波段收发器、ADC、DSP和13.56 mhz无线电源的SOC提供载波信号和时钟信号。在所提出的级联锁相环中,第一个锁相环提供采样时钟,第二个锁相环提供载波时钟。利用无线电力传输系统接收线圈的13.56 mhz信号作为输入参考信号。基于环的压控振荡器(VCO)的设计是为了最小化功耗和芯片面积。所提出的级联锁相环采用0.18 μm CMOS工艺设计和实现。在402.9 MHz下,测量到的相位噪声为-79 dBc/Hz,偏移量为100khz。在1.8V电源电压下,第一个锁相环的测量功耗为0.28 mW,第二个锁相环的测量功耗为0.46mW。所提出的级联锁相环具有功耗低、片面积小、无片外元件和晶体振荡器等优点。适合与植入式医疗soc集成。
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引用次数: 7
期刊
2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)
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