Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679682
Tzu-Yun Wang, M. Lai, C. Twigg, Sheng-Yu Peng
In this paper, we present a fully reconfigurable biopotential sensing amplifier, which employs floating-gate transistors for the programming of the low-frequency cutoff corner and for and for common-mode feedback implementation without consuming any extra power. With a supply voltage of 2.5V, the measured midband gain is 40.7dB and the measured input-referred noise is 2.8 μVrms. The chip was tested under several configurations with the amplifier bandwidth being programmed to 100Hz, 1kHz, and 10 kHz. The measured noise efficiency factors in these bandwidth settings are 1.96, 2.01 and 2.25. The measured common-mode rejection and the supply rejection are above 70 dB. The measured dynamic range is 60 dB with total harmonic distortion less than 0.1%.
{"title":"A fully reconfigurable low-noise biopotential sensing amplifier","authors":"Tzu-Yun Wang, M. Lai, C. Twigg, Sheng-Yu Peng","doi":"10.1109/BioCAS.2013.6679682","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679682","url":null,"abstract":"In this paper, we present a fully reconfigurable biopotential sensing amplifier, which employs floating-gate transistors for the programming of the low-frequency cutoff corner and for and for common-mode feedback implementation without consuming any extra power. With a supply voltage of 2.5V, the measured midband gain is 40.7dB and the measured input-referred noise is 2.8 μVrms. The chip was tested under several configurations with the amplifier bandwidth being programmed to 100Hz, 1kHz, and 10 kHz. The measured noise efficiency factors in these bandwidth settings are 1.96, 2.01 and 2.25. The measured common-mode rejection and the supply rejection are above 70 dB. The measured dynamic range is 60 dB with total harmonic distortion less than 0.1%.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121732138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679629
C. M. Andreou, Yiannis Pahitas, Evdokia Pilavaki, J. Georgiou
A micro-fluidic gyroscope that mimics the natural vestibular semicircular canals (SCC) is presented. This gyro takes advantage of a hybrid MEMS process that combines micro-fluidic channels on micro-machined glass wafers with active components realized in silicon wafers. The proposed gyro offers significant advantages in terms of power consumption and reliability compared to prior art. The presented structures were fabricated using Infineon MultiMEMS process and the occupied area is 6mm2 including the pads area.
{"title":"Bio-mimetic gyroscopic sensor for vestibular prostheses","authors":"C. M. Andreou, Yiannis Pahitas, Evdokia Pilavaki, J. Georgiou","doi":"10.1109/BioCAS.2013.6679629","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679629","url":null,"abstract":"A micro-fluidic gyroscope that mimics the natural vestibular semicircular canals (SCC) is presented. This gyro takes advantage of a hybrid MEMS process that combines micro-fluidic channels on micro-machined glass wafers with active components realized in silicon wafers. The proposed gyro offers significant advantages in terms of power consumption and reliability compared to prior art. The presented structures were fabricated using Infineon MultiMEMS process and the occupied area is 6mm2 including the pads area.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"155 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125909441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679691
Hossein Kassiri, K. Abdelhalim, R. Genov
A low-distortion super-GOhm subthreshold MOS resistor is designed, fabricated and experimentally validated. The circuit is utilized as a feedback element in the body of a two-stage neural recording amplifier. Linearity is experimentally validated for 0.5 Hz to 5 kHz input frequency and over 0.3 to 0.9 V output voltage dynamic range. The implemented pseudo resistor is also tunable, making the high-pass filter pole adjustable. The circuit is fabricated in 0.13-μm CMOS process and consumes 96 nW from a 1.2 V supply to realize an over 500 GΩ resistance.
{"title":"Low-distortion super-GOhm subthreshold-MOS resistors for CMOS neural amplifiers","authors":"Hossein Kassiri, K. Abdelhalim, R. Genov","doi":"10.1109/BioCAS.2013.6679691","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679691","url":null,"abstract":"A low-distortion super-GOhm subthreshold MOS resistor is designed, fabricated and experimentally validated. The circuit is utilized as a feedback element in the body of a two-stage neural recording amplifier. Linearity is experimentally validated for 0.5 Hz to 5 kHz input frequency and over 0.3 to 0.9 V output voltage dynamic range. The implemented pseudo resistor is also tunable, making the high-pass filter pole adjustable. The circuit is fabricated in 0.13-μm CMOS process and consumes 96 nW from a 1.2 V supply to realize an over 500 GΩ resistance.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128979220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679717
M. Madec, F. Pêcheux, Yves Gendrault, Loic Bauer, J. Haiech, C. Lallement
The topic of this paper is to develop an open-source framework to help bio-engineers through the different stages of a top-down design process for new artificial biosystems (synthetic biology). The presented tools address the upstream stages of the design, starting from a high-level behavioral description of the targeted biological function and ending with a working assembly of abstract BioBricks performing that very function. For that purpose, EDA (Electronic Design Automation) tools are indeed adapted to synthetic biology. The framework involves three main steps: the interpretation of the high-level description into a netlist of logical functions, the optimization of the netlist with respect to BioBricks capabilities and the automated generation of a SystemC-AMS abstracted simulatable netlist that can be used for further analysis (low-level simulation, optimization ...). Throughout the paper, each stage of the framework is detailed and illustrated with a simple (from a logical point of view) but complex (from the biological viewpoint) example: an in-vivo chemical species regulation system.
{"title":"EDA inspired open-source framework for synthetic biology","authors":"M. Madec, F. Pêcheux, Yves Gendrault, Loic Bauer, J. Haiech, C. Lallement","doi":"10.1109/BioCAS.2013.6679717","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679717","url":null,"abstract":"The topic of this paper is to develop an open-source framework to help bio-engineers through the different stages of a top-down design process for new artificial biosystems (synthetic biology). The presented tools address the upstream stages of the design, starting from a high-level behavioral description of the targeted biological function and ending with a working assembly of abstract BioBricks performing that very function. For that purpose, EDA (Electronic Design Automation) tools are indeed adapted to synthetic biology. The framework involves three main steps: the interpretation of the high-level description into a netlist of logical functions, the optimization of the netlist with respect to BioBricks capabilities and the automated generation of a SystemC-AMS abstracted simulatable netlist that can be used for further analysis (low-level simulation, optimization ...). Throughout the paper, each stage of the framework is detailed and illustrated with a simple (from a logical point of view) but complex (from the biological viewpoint) example: an in-vivo chemical species regulation system.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132637231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679632
Jen-Huo Wang, K. Tang, Hsin Chen
An embedded system capable of recognizing biomedical signals reliably is important for fusing sensory data of portable or implantable microsystems in biomedical applications. This paper presents the digital VLSI implementation of the probabilistic neural network, called the Continuous Restricted Boltzmann Machine (CRBM), which is able to cluster or to classify sensory data of an electronic nose. The learning algorithm of the CRBM is also realized on the same chip, such that the CRBM system is able to optimize its parameters automatically, or to compensate for sensory drifts by on-line learning.
{"title":"An embedded probabilistic neural network with on-chip learning capability","authors":"Jen-Huo Wang, K. Tang, Hsin Chen","doi":"10.1109/BioCAS.2013.6679632","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679632","url":null,"abstract":"An embedded system capable of recognizing biomedical signals reliably is important for fusing sensory data of portable or implantable microsystems in biomedical applications. This paper presents the digital VLSI implementation of the probabilistic neural network, called the Continuous Restricted Boltzmann Machine (CRBM), which is able to cluster or to classify sensory data of an electronic nose. The learning algorithm of the CRBM is also realized on the same chip, such that the CRBM system is able to optimize its parameters automatically, or to compensate for sensory drifts by on-line learning.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116936508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679713
Changhyuk Lee, Ben Johnson, A. Molnar
We demonstrate an inductively powered, orthogonal current-reuse multi-channel amplifier for power-efficient neural recording. The power rectifier uses the input swing as a self-synchronous charge pump, making it a fully passive, full-wave ladder rectifier. The rectifier supplies 10.37μW at 1.224V to the multi-channel amplifier, which includes bias generation. The prototype device is fabricated in a TSMC 65nm CMOS process, with an active area of 0.107mm2. The maximum measured power conversion efficiency (PCE) is 16.58% with a 184mV input amplitude.
{"title":"A sub-threshold voltage ladder rectifier for orthogonal current-reuse neural amplifier","authors":"Changhyuk Lee, Ben Johnson, A. Molnar","doi":"10.1109/BioCAS.2013.6679713","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679713","url":null,"abstract":"We demonstrate an inductively powered, orthogonal current-reuse multi-channel amplifier for power-efficient neural recording. The power rectifier uses the input swing as a self-synchronous charge pump, making it a fully passive, full-wave ladder rectifier. The rectifier supplies 10.37μW at 1.224V to the multi-channel amplifier, which includes bias generation. The prototype device is fabricated in a TSMC 65nm CMOS process, with an active area of 0.107mm2. The maximum measured power conversion efficiency (PCE) is 16.58% with a 184mV input amplitude.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114621337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679625
Shih-Lin Huang, Jinyong Zhang, Lei Wang
Since the fabrication of active electrodes has been reported and their beneficial effects scientifically confirmed, we present a CMOS bioelectric amplifier with DC rejection designed for active electrode in this paper. Analysis, design and post simulation results will be described in detail. The amplifier operating at ±0.9V supply voltage has a mid-band gain of 40dB with ±300mV dc offset rejection and has a power consumption of 6.7μW. The bandwidth extends from a low-frequency cutoff of 7.9mHz to a high-frequency cutoff of 2.1kHz which is suitable for ECG signals. This proposed amplifier has an input-referred noise of 5.9μVrms. This amplifier is under fabrication in 0.18μm 1P6M CMOS Process.
{"title":"A 6.7µW CMOS bioamplifier for active electrode with DC rejection","authors":"Shih-Lin Huang, Jinyong Zhang, Lei Wang","doi":"10.1109/BioCAS.2013.6679625","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679625","url":null,"abstract":"Since the fabrication of active electrodes has been reported and their beneficial effects scientifically confirmed, we present a CMOS bioelectric amplifier with DC rejection designed for active electrode in this paper. Analysis, design and post simulation results will be described in detail. The amplifier operating at ±0.9V supply voltage has a mid-band gain of 40dB with ±300mV dc offset rejection and has a power consumption of 6.7μW. The bandwidth extends from a low-frequency cutoff of 7.9mHz to a high-frequency cutoff of 2.1kHz which is suitable for ECG signals. This proposed amplifier has an input-referred noise of 5.9μVrms. This amplifier is under fabrication in 0.18μm 1P6M CMOS Process.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"262 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124277511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679690
E. Tóth, K. Iván, P. Fürjes, Z. Fekete, E. Holczer
In this work we present the design aspects of special microfluidic structures applicable to dilute and transport analyte solutions (such as whole blood) to the sensing area of biosensors. Our goal is to design and realise a reliable microfluidic system which is applicable for effective sample transport and can accomplish simple sample preparation functions such as mixing to ensure homogeneous concentration distribution of the species along the fluidic channel. The behaviour of different chaotic mixers were analysed by numerical modeling and experimentally to determine their efficiency. At first we used the concentration distribution method, however because of numerical diffusion this required higher mesh resolutions. Using the particle tracing method is more efficient according to the experimental results and requires lower computational effort. The microstructures were realised by micro-fabrication in polydimethylsiloxane (PDMS) and integrated into a real microfluidic transport system. The functional performance was verified by biological analyte.
{"title":"Design, realisation and validation of microfluidic stochastic mixers integrable in bioanalytical systems using CFD modeling","authors":"E. Tóth, K. Iván, P. Fürjes, Z. Fekete, E. Holczer","doi":"10.1109/BioCAS.2013.6679690","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679690","url":null,"abstract":"In this work we present the design aspects of special microfluidic structures applicable to dilute and transport analyte solutions (such as whole blood) to the sensing area of biosensors. Our goal is to design and realise a reliable microfluidic system which is applicable for effective sample transport and can accomplish simple sample preparation functions such as mixing to ensure homogeneous concentration distribution of the species along the fluidic channel. The behaviour of different chaotic mixers were analysed by numerical modeling and experimentally to determine their efficiency. At first we used the concentration distribution method, however because of numerical diffusion this required higher mesh resolutions. Using the particle tracing method is more efficient according to the experimental results and requires lower computational effort. The microstructures were realised by micro-fabrication in polydimethylsiloxane (PDMS) and integrated into a real microfluidic transport system. The functional performance was verified by biological analyte.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124280650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679641
T. Datta, E. Naviasky, P. Abshire
This paper describes a new design for a capacitance sensor array to monitor cell viability that uses floating gate compensation techniques to mitigate device mismatch. The measurement is carried out using sensor evaluation modules that employ a charge based capacitance measurement technique to quantify differential capacitance at the sensor pixel elements. Previous results from compensated structures and new data collected from in-vitro cell culture on the surface of an uncompensated array were used to inform the design of a new array. We examine array level architectural tradeoffs and sensing electrode configurations in order to design a high density sensor array with minimal sources of variability.
{"title":"Floating-gate capacitance sensor array for cell viability monitoring","authors":"T. Datta, E. Naviasky, P. Abshire","doi":"10.1109/BioCAS.2013.6679641","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679641","url":null,"abstract":"This paper describes a new design for a capacitance sensor array to monitor cell viability that uses floating gate compensation techniques to mitigate device mismatch. The measurement is carried out using sensor evaluation modules that employ a charge based capacitance measurement technique to quantify differential capacitance at the sensor pixel elements. Previous results from compensated structures and new data collected from in-vitro cell culture on the surface of an uncompensated array were used to inform the design of a new array. We examine array level architectural tradeoffs and sensing electrode configurations in order to design a high density sensor array with minimal sources of variability.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123706566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-12-12DOI: 10.1109/BioCAS.2013.6679637
L. Constantinou, A. Demosthenous
Bioimpedance measurements are performed in a wide range of frequencies (100Hz to 1MHz) as physiological tissue information is scattered throughout this frequency band. Wideband current drivers with high output impedance are essential to maintain high injected current accuracy over a wide range of load impedances. The purpose of the work presented in this paper is the design methodology of a fully integrated, wideband current driver for bioimpedance measurement systems. The circuit has been designed and simulated in a standard CMOS 0.6-um technology delivering currents of up to 2mA pk-pk operating from a ±6V power supply. Results show an output current phase delay of -2.43° at 1MHz and an output impedance of 8MΩ at 100Hz reducing to 1.08MΩ at 1MHz.
{"title":"A wideband CMOS current driver for bioimpedance applications with output DC regulation","authors":"L. Constantinou, A. Demosthenous","doi":"10.1109/BioCAS.2013.6679637","DOIUrl":"https://doi.org/10.1109/BioCAS.2013.6679637","url":null,"abstract":"Bioimpedance measurements are performed in a wide range of frequencies (100Hz to 1MHz) as physiological tissue information is scattered throughout this frequency band. Wideband current drivers with high output impedance are essential to maintain high injected current accuracy over a wide range of load impedances. The purpose of the work presented in this paper is the design methodology of a fully integrated, wideband current driver for bioimpedance measurement systems. The circuit has been designed and simulated in a standard CMOS 0.6-um technology delivering currents of up to 2mA pk-pk operating from a ±6V power supply. Results show an output current phase delay of -2.43° at 1MHz and an output impedance of 8MΩ at 100Hz reducing to 1.08MΩ at 1MHz.","PeriodicalId":344317,"journal":{"name":"2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127736722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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