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2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)最新文献

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An active TX/RX NMR probe for real-time monitoring of MRI field imperfections 一种用于实时监测核磁共振场缺陷的主动TX/RX核磁共振探针
Pub Date : 2013-12-12 DOI: 10.1109/BIOCAS.2013.6679672
J. Handwerker, M. Ortmanns, J. Anders, M. Eschelbach, P. Chang, A. Henning, K. Scheffler
In this paper, we present a PCB-based active miniaturized MR field probe for real-time monitoring of the magnetization's phase evolution during magnetic resonance (MR) experiments. The data obtained with the presented sensor can be used to correct gradient field imperfections which uncorrected result in significant distortions in the reconstructed MR images. The presented active field probe consists of a susceptibility matched solenoidal MR coil and a complete homodyne transceiver. Thanks to the local generation of the radio frequency signal required for the excitation of the spin ensemble and the downconversion of the recorded MR signal to low frequencies, the proposed architecture significantly reduces the crosstalk between the probe head and the MR imaging object compared to existing designs. MR measurements performed in an ultra high field 9.4 T full-body scanner prove the compatibility of the presented sensor with commercial MR imaging systems and demonstrate its excellent MR phase tracking performance.
在本文中,我们提出了一种基于pcb的有源小型化磁共振场探头,用于实时监测磁共振(MR)实验中磁化的相位演变。利用该传感器获得的数据可用于校正梯度场缺陷,这些缺陷在重建的MR图像中会导致显著的畸变。提出的有源磁场探头由磁化率匹配的螺线管磁流变线圈和一个完整的纯差收发器组成。由于自旋系综激发所需的射频信号在局部产生,并将记录的MR信号下转换为低频,与现有设计相比,所提出的架构显著减少了探头与MR成像对象之间的串扰。在超高场9.4 T全身扫描仪上进行的MR测量证明了该传感器与商用MR成像系统的兼容性,并展示了其出色的MR相位跟踪性能。
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引用次数: 6
Multi-electrode amperometric biosensor for neurotransmitters detection 用于神经递质检测的多电极安培生物传感器
Pub Date : 2013-12-12 DOI: 10.1109/BIOCAS.2013.6679664
G. Massicotte, M. Sawan, G. Micheli, S. Carrara
Multi-target detection of neurochemicals is crucial to elucidate brain chemical signaling interplay. We describe in this paper an efficient experimental method to detect 2 types of neurotransmitters and the subsequent implementation of a dedicated potentiostat custom circuit. The experimental method is based on a biosensor performing constant-potential amperometry for an efficient detection of neurotransmitters, such as dopamine and glutamate, using a Carbon-nanotube (CNT)-based multi-working electrode sensor, which offers high sensitivity and selectivity. The custom CMOS time-based potentiostat circuit, designed to accommodate the detection of a wide variety of neurochemicals, is used as transducer. The proposed design is characterized through post-layout simulations, showing a wide dynamic input current range of 20 pA to 800 nA, and an input referred noise of 0.13 pA/√Hz. The circuit dissipates 56 μW for a minimum sampling frequency of 1.25 kHz. Circuit performances fully satisfies the requirements for the developed dopamine and glutamate sensors. The proposed biosensor configuration can be extended to the detection of a large number of neurochemicals.
神经化学物质的多靶点检测对于阐明脑化学信号相互作用至关重要。在本文中,我们描述了一种有效的实验方法来检测两种类型的神经递质,并随后实现了一个专用的恒电位器定制电路。该实验方法是基于一种生物传感器进行恒电位安培法,用于有效检测神经递质,如多巴胺和谷氨酸,使用基于碳纳米管(CNT)的多工作电极传感器,具有高灵敏度和选择性。定制的CMOS基于时间的恒电位器电路,设计用于适应各种神经化学物质的检测,被用作传感器。通过布局后仿真验证了该设计的特点,其动态输入电流范围为20 pA至800 nA,输入参考噪声为0.13 pA/√Hz。电路功耗为56 μW,最小采样频率为1.25 kHz。电路性能完全满足发达的多巴胺和谷氨酸传感器的要求。提出的生物传感器配置可以扩展到大量的神经化学物质的检测。
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引用次数: 5
A spiking neural network architecture for visual motion estimation 一种用于视觉运动估计的峰值神经网络结构
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679698
G. Orchard, R. Benosman, R. Etienne-Cummings, N. Thakor
Current interest in neuromorphic computing continues to drive development of sensors and hardware for spike-based computation. Here we describe a hierarchical architecture for visual motion estimation which uses a spiking neural network to exploit the sparse high temporal resolution data provided by neuromorphic vision sensors. Although spike-based computation differs from traditional computer vision approaches, our architecture is similar in principle to the canonical Lucas-Kanade algorithm. Output spikes from the architecture represent the direction of motion to the nearest 45 degrees, and the speed within a factor of √2 over the range 0.02 to 0.27 pixels/ms.
当前对神经形态计算的兴趣继续推动基于峰值计算的传感器和硬件的发展。本文描述了一种视觉运动估计的分层结构,该结构利用尖峰神经网络来利用神经形态视觉传感器提供的稀疏高时间分辨率数据。尽管基于峰值的计算与传统的计算机视觉方法不同,但我们的架构在原则上与经典的Lucas-Kanade算法相似。从架构的输出尖峰表示运动的方向到最近的45度,并在√2因子范围内0.02至0.27像素/ms的速度。
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引用次数: 47
A compact Gm-C filter architecture with an ultra-low corner frequency and high ground-noise rejection 一种紧凑的Gm-C滤波器结构,具有超低角频率和高地噪声抑制
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679703
Yu-Chieh Lee, Wen-Yang Hsu, Tai-Ting Huang, Hsin Chen
Active filters with a very low corner frequency (of only a few hertz or below) are usually demanded at the frontend circuitry of biomedical instruments. This paper presents a novel circuit architecture for implementing the Bessel low-pass filter with an ultra-low corner frequency and negligible interferences from the ground. Basing on the transconductance-capacitor (Gm-C) architecture, the proposed filter incorporates a differential amplifier into the negative feedback loop to scale down the corner frequency, as well as to eliminate noise coupling from the ground. To demonstrate the design concept, a second-order Bessel filter is fabricated with the 0.35μm CMOS technology. With a corner frequency of around 1Hz, the filter consumes only 1.2μW and a chip area of 0.089mm2. Moreover, the 60-Hz interference from the ground is proved to be attenuated by more than 36dB.
生物医学仪器的前端电路通常要求具有极低角频率(仅几赫兹或更低)的有源滤波器。本文提出了一种实现贝塞尔低通滤波器的新颖电路结构,该滤波器具有超低角频率和可忽略地干扰。基于跨导电容(Gm-C)结构,该滤波器在负反馈回路中加入一个差分放大器,以减小拐角频率,并消除来自地面的噪声耦合。为了验证设计理念,采用0.35μm CMOS技术制作了二阶贝塞尔滤波器。转角频率约为1Hz,滤波器功耗仅为1.2μW,芯片面积为0.089mm2。此外,来自地面的60hz干扰被证明衰减了36dB以上。
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引用次数: 8
An implantable bio-micro-system for drug monitoring 一种用于药物监测的植入式生物微系统
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679678
S. Ghoreishizadeh, Enver G. Kilinc, C. Baj-Rossi, C. Dehollain, S. Carrara, G. Micheli
Multi-target and continuous monitoring by wireless implantable devices is of increasing interest for personalized therapy. In this work an implantable system is presented which is capable of measuring different drugs with Cyclic Voltammetry (CV) method. The wireless microsystem consists of four modules, namely (i) The inductive coil; (ii) Power management IC; (iii) Readout and control IC; (iv) Biosensor array. The power management IC provides 1.8 V with as high as 2 mW power for the readout IC. The configurable readout IC is able to control the biosensor array and measure the sensor current in CV method. CV experiments performed with this microsystem well agree with a commercial equipment for two well known anti-cancer drugs, Etoposide and Mitoxantrone, detection.
无线植入式装置的多靶点连续监测是个性化治疗的重要手段。本文介绍了一种可植入的循环伏安法药物检测系统。无线微系统由四个模块组成,即(i)感应线圈;电源管理集成电路;读出和控制集成电路;(iv)生物传感器阵列。电源管理IC为读出IC提供1.8 V和高达2 mW的功率。可配置的读出IC能够控制生物传感器阵列并以CV法测量传感器电流。用该微系统进行的CV实验与两种知名抗癌药物依托泊苷和米托蒽醌的商用检测设备非常吻合。
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引用次数: 13
Predicting effective drug combinations via network propagation 通过网络传播预测有效的药物组合
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679718
B. Ligeti, Roberto Vera, Gergely Lukács, Balázs Győrffy, S. Pongor
Drug combinations are frequently used in treating complex diseases including cancer, diabetes, arthritis and hypertension. Most drug combinations were found in empirical ways so there is a need of efficient computational methods. Here we present a novel method based on network analysis which estimates the efficacy of drug combinations from a perturbation analysis performed on a protein-protein association network. The results suggest that those drugs are likely to form effective combinations that perturb a large number of proteins in common, even if the original targets are found in seemingly unrelated pathways.
药物组合经常用于治疗复杂疾病,包括癌症、糖尿病、关节炎和高血压。大多数药物组合都是通过经验方法发现的,因此需要有效的计算方法。在这里,我们提出了一种基于网络分析的新方法,该方法通过对蛋白质-蛋白质关联网络进行的扰动分析来估计药物组合的疗效。结果表明,这些药物很可能形成有效的组合,扰乱大量共同的蛋白质,即使最初的目标是在看似不相关的途径中发现的。
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引用次数: 5
Bio-feedback iontophoresis patch for controllable transdermal drug delivery 可控透皮给药的生物反馈离子导入贴片
Pub Date : 2013-12-12 DOI: 10.1109/BIOCAS.2013.6679706
Kiseok Song, U. Ha, Jaehyuk Lee, H. Yoo
The bio-feedback iontophoresis patch is proposed for controllable transdermal drug delivery. The proposed iontophoresis patch is implemented with the bio-feedback iontophoresis integrated circuit (IC) on the planar-fashionable circuit board (P-FCB) technology. For controllable iontophoresis treatment, the bio-feedback iontophoresis IC provides programmable stimulation current (16-512μA amplitude, DC-500Hz frequency, and 3-100% duty cycle) and monitors the dual-mode (load and tissue) impedance and the skin temperature during iontophoresis treatment with the reconfigurable tetra-polar electrode configuration. The load impedance is used to determine the stimulation current level, which means the instantaneous delivered dosage, for optimized iontophoresis treatment. The measured tissue impedance is used as an indicator of the accumulated delivered dosage. The skin temperature sensor prevents the unexpected side effects, such as skin burn or tissue destruction. As a result, the proposed iontophoresis patch monitors drug delivery status and patient's status. The proposed iontophoresis system is fully implemented and verified on both in-vitro and in-vivo tests.
提出了一种生物反馈离子导入贴片,用于可控的透皮给药。所提出的离子导入贴片采用平面时尚电路板(P-FCB)技术上的生物反馈离子导入集成电路(IC)实现。为了实现可控的离子透入处理,生物反馈离子透入IC提供可编程的刺激电流(16-512μA振幅,DC-500Hz频率,3-100%占空比),并通过可重构的四极电极配置监测离子透入处理过程中的双模(负载和组织)阻抗和皮肤温度。负载阻抗用于确定刺激电流水平,即瞬时输送剂量,以优化离子导入处理。测量的组织阻抗用作累积递送剂量的指示器。皮肤温度传感器防止意外的副作用,如皮肤烧伤或组织破坏。因此,所提出的离子透入贴片监测药物递送状态和患者状态。所提出的离子透入系统在体外和体内测试中都得到了充分的实施和验证。
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引用次数: 2
Fuzzy logic, an intermediate description level for design and simulation in synthetic biology 模糊逻辑:合成生物学中设计与仿真的中间描述层次
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679716
Yves Gendrault, M. Madec, V. Wlotzko, C. Lallement, J. Haiech
Synthetic biology, or biological engineering, is a new science which may take advantage of the know-how of engineering science in order to build new in-vivo biological functions. The complete design process implies lots of modeling and simulation tasks. The design flow for this technology uses “digital” models at high level of abstraction as well as “analogue” ones at low level. Nevertheless, contrary to electronics, high-level digital descriptions are far away from low-level ones. In this paper, an intermediate modeling level using the principle of fuzzy logic is proposed to fill the gap between high and low abstraction level. The main advantage of this approach is to obtain quantitative simulation results while keeping a behavioral description of mechanisms. This is pointed out through two examples. The first one, encountered in literature, tends to prove that this modeling level is sufficient to obtain reliable results in comparison with the experimental ones. The second one, which is more theoretical, demonstrates the interest of fuzzy logic from a designing point of view.
合成生物学或生物工程是一门新的科学,它可以利用工程科学的专有技术来构建新的体内生物功能。完整的设计过程意味着大量的建模和仿真任务。该技术的设计流程在高层次抽象上使用“数字”模型,在低级抽象上使用“模拟”模型。然而,与电子学相反,高级数字描述与低级数字描述相去甚远。本文提出了一种利用模糊逻辑原理的中间建模层来填补高抽象层和低抽象层之间的空白。这种方法的主要优点是在保持机制行为描述的同时获得定量模拟结果。这是通过两个例子指出的。文献中遇到的第一种倾向于证明该建模水平足以获得与实验结果相比较的可靠结果。第二种方法更理论化,从设计的角度展示了模糊逻辑的兴趣。
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引用次数: 5
Externally-coupled transcutaneous energy transmission for a ventricular assist device-Miniaturization of ferrite core and evaluation of biological effects around the transformer 心室辅助装置的外耦合经皮能量传输——铁氧体磁心的小型化和变压器周围生物效应的评估
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679675
T. Shibuya, K. Shiba
This paper reports on the miniaturization of the ferrite core of an externally-coupled transcutaneous transformer (ECTT) for a ventricular assist system. First, we designed the miniaturization of the ECTT and measured the transmission efficiency. We investigated whether the ferrite core of the ECTT could be miniaturized without a decline in the efficiency. Secondly, the electromagnetic simulator was analyzed via the specific absorption rate and the internal electric field strength in the human body by employing the transmission line modeling method. As a result, a maximum energy transmission efficiency of 98.20% (12 turns) was obtained by the miniaturization of the ECTT. Additionally, electromagnetic analysis of the biological effects revealed that the internal electric field falls well below the guidelines of the International Commission on Non-Ionizing Radiation Protection for frequencies above 300 kHz. The miniaturized ECTT is confirmed to be safe for transmission frequencies over 300 kHz.
本文报道了用于心室辅助系统的外耦合经皮变压器(ECTT)铁氧体磁芯的小型化。首先,我们设计了ECTT的小型化,并测量了其传输效率。我们研究了ECTT的铁氧体磁芯能否在不降低效率的情况下小型化。其次,采用传输线建模的方法,通过比吸收率和人体内部电场强度对电磁模拟器进行分析。结果表明,ECTT的小型化使其最大能量传输效率达到98.20%(12转)。此外,对生物效应的电磁分析显示,内部电场远远低于国际非电离辐射防护委员会对300千赫以上频率的指导方针。小型化的ECTT被证实在超过300千赫的传输频率下是安全的。
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引用次数: 6
A signal-specific approach for reducing SAR-ADC power consumption 降低SAR-ADC功耗的特定信号方法
Pub Date : 2013-12-12 DOI: 10.1109/BioCAS.2013.6679693
Ken Chia-Han Chiang, N. S. Artan, H. J. Chao
A novel power optimization technique, called adaptive tracking is proposed in this paper for successive approximation analog-to-digital converters aiming implantable device applications. A SAR-ADC can easily be equipped with the proposed tracking technique by a minor modification in its digital circuitry (SAR). This work relies on the similarity of consecutive sample values in band-limited bio-potentials. The proposed adaptive tracking scheme can reduce power consumption of a wide variety of SAR-ADCs. In particular, we show that the tracking scheme can save 30% of power in a conventional SAR-ADC, 31% of power in those using binary SAR-ADCs using a weighted DAC with split MSB capacitor, and 8% of power in those using charge sharing DAC.
针对可植入器件应用的逐次逼近模数转换器,提出了一种新的功率优化技术——自适应跟踪。通过对其数字电路(SAR)进行微小修改,SAR- adc可以很容易地配备所提出的跟踪技术。这项工作依赖于带限生物电位中连续样品值的相似性。所提出的自适应跟踪方案可以降低各种sar - adc的功耗。特别是,我们表明跟踪方案可以在传统SAR-ADC中节省30%的功率,在使用带有分裂MSB电容器的加权DAC的二进制SAR-ADC中节省31%的功率,在使用电荷共享DAC的二进制SAR-ADC中节省8%的功率。
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引用次数: 10
期刊
2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)
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