Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412373
M. Frenz, J. Niederhauser, M. Jaeger
A key element of optoacoustic diagnostics, which employs short laser pulses to generate ultrasonic pressure transients in tissues is besides a homogeneous illumination the optimum design of the pressure transducer. Different piezo-electrically and optically based pressure transducers will be compared and discussed.
{"title":"Optical and piezo-electrical pressure transducers for optoacoustic imaging and tissue diagnostics: a comparative study","authors":"M. Frenz, J. Niederhauser, M. Jaeger","doi":"10.1109/APBP.2004.1412373","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412373","url":null,"abstract":"A key element of optoacoustic diagnostics, which employs short laser pulses to generate ultrasonic pressure transients in tissues is besides a homogeneous illumination the optimum design of the pressure transducer. Different piezo-electrically and optically based pressure transducers will be compared and discussed.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121932498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412316
T. Nouchi, M. Akiba, K. Chan
We describe a parallel heterodyne detection method for real-time spectroscopic optical coherence tomography. Spectroscopic measurements using an ultrabroadband femtosecond Ti:sapphire laser has been carried out, demonstrating the feasibility of the present method.
{"title":"Spectroscopic measurement in turbid media by spectroscopic optical coherence tomography","authors":"T. Nouchi, M. Akiba, K. Chan","doi":"10.1109/APBP.2004.1412316","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412316","url":null,"abstract":"We describe a parallel heterodyne detection method for real-time spectroscopic optical coherence tomography. Spectroscopic measurements using an ultrabroadband femtosecond Ti:sapphire laser has been carried out, demonstrating the feasibility of the present method.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"10 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128738042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412377
C. Liao, Pai-Chi Li
In this paper, we present a reconstruction algorithm for backward mode optoacoustic imaging. The algorithm is developed from the optoacoustic wave equations and takes advantage of the simplification associated with line focusing, which is implemented with a synthetic aperture focusing and adaptive weighting method. Computer simulations and experiments were conducted to verify efficacy of the algorithm. Performance differences between numerical simulations and the experiments will be presented and discussed.
{"title":"Reconstruction of optical absorption distribution for backward optoacoustic imaging","authors":"C. Liao, Pai-Chi Li","doi":"10.1109/APBP.2004.1412377","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412377","url":null,"abstract":"In this paper, we present a reconstruction algorithm for backward mode optoacoustic imaging. The algorithm is developed from the optoacoustic wave equations and takes advantage of the simplification associated with line focusing, which is implemented with a synthetic aperture focusing and adaptive weighting method. Computer simulations and experiments were conducted to verify efficacy of the algorithm. Performance differences between numerical simulations and the experiments will be presented and discussed.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126464168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412338
J.i.e. Chen, T. Chiu, Wen Lo, Sung-Jan Lin, S. Jee, C. Dong
Drug delivery through skin has benefits such as its conveniences of providing controlled dosage to patients. In this article we investigate the effects of electrical characteristics of molecules on their effectiveness in transdermal drug delivery. Using multiphoton microscopy, we imaged the skin treated with fluorescent model drugs having different charges. We will present both the images obtained at different depths and axial fluorescence intensity profiles. Multiphoton microscopy is a useful technique for mechanistic analysis in transdermal drug delivery.
{"title":"The effect of electrical charge on drug delivery through skin","authors":"J.i.e. Chen, T. Chiu, Wen Lo, Sung-Jan Lin, S. Jee, C. Dong","doi":"10.1109/APBP.2004.1412338","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412338","url":null,"abstract":"Drug delivery through skin has benefits such as its conveniences of providing controlled dosage to patients. In this article we investigate the effects of electrical characteristics of molecules on their effectiveness in transdermal drug delivery. Using multiphoton microscopy, we imaged the skin treated with fluorescent model drugs having different charges. We will present both the images obtained at different depths and axial fluorescence intensity profiles. Multiphoton microscopy is a useful technique for mechanistic analysis in transdermal drug delivery.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121659931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-14DOI: 10.1109/APBP.2004.1412301
C. You, Hsin-Ming Chen, C. Chiang, Chin-Tin Chen, Chih-Yu Wang
In this study, we evaluate the feasibility of using time-resolved autofluorescence spectroscopy for differentiating normal oral mucosa (NOM) from oral premalignant lesions including verrucous hyperplasia (VH), epithelial hyperplasia (EH), and epithelial dysplasia (ED). Time-resolved autofluorescence was measured at 633 nm under 410-nm excitation for 15 VH, 9 EH, 14 ED, and 38 NOM samples, and the two-component lifetimes for each measurement were calculated and a two-dimensional scatter plot was constructed. A Fisher's discriminant analysis (FDA) were used to classify the 4 types of tissues. The result showed that 71% of EH and VH, 86% of ED, and 100% of NOM samples were correctly identified.
{"title":"Autofluorescence lifetime for identifying premalignant and normal oral tissues","authors":"C. You, Hsin-Ming Chen, C. Chiang, Chin-Tin Chen, Chih-Yu Wang","doi":"10.1109/APBP.2004.1412301","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412301","url":null,"abstract":"In this study, we evaluate the feasibility of using time-resolved autofluorescence spectroscopy for differentiating normal oral mucosa (NOM) from oral premalignant lesions including verrucous hyperplasia (VH), epithelial hyperplasia (EH), and epithelial dysplasia (ED). Time-resolved autofluorescence was measured at 633 nm under 410-nm excitation for 15 VH, 9 EH, 14 ED, and 38 NOM samples, and the two-component lifetimes for each measurement were calculated and a two-dimensional scatter plot was constructed. A Fisher's discriminant analysis (FDA) were used to classify the 4 types of tissues. The result showed that 71% of EH and VH, 86% of ED, and 100% of NOM samples were correctly identified.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127980470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.1109/APBP.2004.1412358
K. Sakaguchi, K. Yokoyama, Y. Watanabe, E. Okada
The spectral reflectance of cortical phantom is measured with a multispectral imaging system. The wavelength-dependent path length factor is estimated from the first principal component of the reflectance spectra of the phantom and is compared with the mean optical path length predicted by Monte Carlo simulation.
{"title":"Estimation of wavelength-dependent path length factor from multispectral images of cortical phantom","authors":"K. Sakaguchi, K. Yokoyama, Y. Watanabe, E. Okada","doi":"10.1109/APBP.2004.1412358","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412358","url":null,"abstract":"The spectral reflectance of cortical phantom is measured with a multispectral imaging system. The wavelength-dependent path length factor is estimated from the first principal component of the reflectance spectra of the phantom and is compared with the mean optical path length predicted by Monte Carlo simulation.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122240114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.1109/APBP.2004.1412328
N. Okui, E. Okada
Near infrared spectroscopy is an effective method to measure the concentration change in oxy-and deoxy-haemoglobin caused by brain activity. In this study, we investigate the relationship between position of focal absorption change in the brain and the cross talk in the results of near-infrared spectroscopy.
{"title":"Cross talk between oxy- and deoxy-haemoglobin in brain function measurement by near-infrared spectroscopy","authors":"N. Okui, E. Okada","doi":"10.1109/APBP.2004.1412328","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412328","url":null,"abstract":"Near infrared spectroscopy is an effective method to measure the concentration change in oxy-and deoxy-haemoglobin caused by brain activity. In this study, we investigate the relationship between position of focal absorption change in the brain and the cross talk in the results of near-infrared spectroscopy.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123493208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.1109/APBP.2004.1412288
Cheng-Jen Chang, P. Wilder-Smith
Light-induced fluorescence detection using Photofrin/sup /spl reg// topically provides a sensitive, noninvasive technique for the early identification of malignant neoplasms in the oral cavity. The development of an endoscopic fluorescence imaging system that could be used for real-time, noninvasive and diagnosis in clinical application.
{"title":"Photodynamic diagnosis of oral neoplasms","authors":"Cheng-Jen Chang, P. Wilder-Smith","doi":"10.1109/APBP.2004.1412288","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412288","url":null,"abstract":"Light-induced fluorescence detection using Photofrin/sup /spl reg// topically provides a sensitive, noninvasive technique for the early identification of malignant neoplasms in the oral cavity. The development of an endoscopic fluorescence imaging system that could be used for real-time, noninvasive and diagnosis in clinical application.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122784876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.1109/APBP.2004.1412289
H. Chien, Yitao Liao, Chin-Tin Chen
The purpose of this clinical study is to develop topical ALA-PDT as an alternative treatment of warts but without the unwanted side effects of pain and burning. Topical ALA-PDT with green LED array proved to be an effective and painless treatment modality for warts.
{"title":"Topical 5-aminolevulinic acid photodynamic therapy for the treatment of warts: comparison of red and green light-emitting diode array","authors":"H. Chien, Yitao Liao, Chin-Tin Chen","doi":"10.1109/APBP.2004.1412289","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412289","url":null,"abstract":"The purpose of this clinical study is to develop topical ALA-PDT as an alternative treatment of warts but without the unwanted side effects of pain and burning. Topical ALA-PDT with green LED array proved to be an effective and painless treatment modality for warts.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115034144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.1109/APBP.2004.1412302
Cheng-De Lin, Chien-Chung Huang, Ching-Hung Chen, Tak-Wah Wong, M. Young
Far-infrared rays (FIR) and infrared rays (IR) generate heat and were claimed to be benefit to wound healing. We compare the differences of light penetration and human skin blood flow between FIR and IR irradiation.
{"title":"Far-infrared rays penetrate deeper into mammary tissue and induce a higher skin blood flow in comparison to infrared irradiation","authors":"Cheng-De Lin, Chien-Chung Huang, Ching-Hung Chen, Tak-Wah Wong, M. Young","doi":"10.1109/APBP.2004.1412302","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412302","url":null,"abstract":"Far-infrared rays (FIR) and infrared rays (IR) generate heat and were claimed to be benefit to wound healing. We compare the differences of light penetration and human skin blood flow between FIR and IR irradiation.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134416382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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