首页 > 最新文献

Clinical Practice and Epidemiology in Mental Health最新文献

英文 中文
Patterns and Predictors of Internet Gaming Disorder: An Observational Study from Jordan. 网络游戏障碍的模式和预测因素:来自约旦的一项观察性研究。
Q2 Medicine Pub Date : 2021-12-22 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010217
Reema Karasneh, Sayer Al-Azzam, Karem H Alzoubi, Mohammad B Nusair, Sahar Hawamdeh, Amal T Nusir

Objective: Internet Gaming Disorder (IGD) is a rapidly growing public health problem that may have detrimental effects. The purpose of this study is to identify factors associated with IGD status.

Methods: In this cross-sectional observational study, a convenient sample of gamers in Jordan was recruited and asked to participate in an online survey based on the nine criteria of the 20-item Internet Gaming Disorder (IGD-20) used to assess gaming disorder. Sociodemographic and psychosocial data were also obtained.

Results: A total of 504 gamers participated in this study. The mean age of respondents was 21.6 ± 3.90 years. Using the standard IGD-20 scale, 96 participants (19%) were classified as potential IGD cases, compared to 408 (80.9%) non-disordered gamers. Males were dominant among the population, constituting 348 (69%) of gamers. Males also played significantly more hours per week [17.8 ±16.75] compared to females [13 ± 17.65]. The majority of gamers (411 (81.5%)) were students, although unemployed adults played for the highest total time [23.9 ± 30.84 hours/week]. Device type used for gaming also significantly (p <0.05) affected the time spent playing. Predictors of IGD included educational level (p< 0.05) and playing hours/week (p< 005). Conversely, no significant associations were found between IGD and gender, age, employment, or sleeping hours. IGD is increasingly being diagnosed among both genders and presents a health challenge for internet users.

Conclusion: Establishing gamer profiles and recognizing predictors of IGD is therefore vital for guiding clinical classification and diagnosis of the disease.

目的:网络游戏障碍(IGD)是一个快速增长的公共卫生问题,可能有有害的影响。本研究的目的是确定与IGD状态相关的因素。方法:在这项横断面观察性研究中,招募了约旦的游戏玩家,并要求他们参与一项基于20项网络游戏障碍(IGD-20)的9项标准的在线调查,用于评估游戏障碍。还获得了社会人口学和社会心理数据。结果:共有504名游戏玩家参与了本研究。受访者平均年龄为21.6±3.90岁。使用标准IGD-20量表,96名参与者(19%)被归类为潜在的IGD病例,相比之下,408名(80.9%)非障碍玩家被归类为潜在的IGD病例。男性玩家占多数,占348人(69%)。男性每周玩游戏的时间(17.8±16.75)也明显多于女性(13±17.65)。大多数玩家(411人(81.5%))是学生,尽管无业成年人玩游戏的总时间最高(23.9±30.84小时/周)。结论:因此,建立玩家档案和识别IGD的预测因素对于指导临床分类和诊断疾病至关重要。
{"title":"Patterns and Predictors of Internet Gaming Disorder: An Observational Study from Jordan.","authors":"Reema Karasneh,&nbsp;Sayer Al-Azzam,&nbsp;Karem H Alzoubi,&nbsp;Mohammad B Nusair,&nbsp;Sahar Hawamdeh,&nbsp;Amal T Nusir","doi":"10.2174/1745017902117010217","DOIUrl":"https://doi.org/10.2174/1745017902117010217","url":null,"abstract":"<p><strong>Objective: </strong>Internet Gaming Disorder (IGD) is a rapidly growing public health problem that may have detrimental effects. The purpose of this study is to identify factors associated with IGD status.</p><p><strong>Methods: </strong>In this cross-sectional observational study, a convenient sample of gamers in Jordan was recruited and asked to participate in an online survey based on the nine criteria of the 20-item Internet Gaming Disorder (IGD-20) used to assess gaming disorder. Sociodemographic and psychosocial data were also obtained.</p><p><strong>Results: </strong>A total of 504 gamers participated in this study. The mean age of respondents was 21.6 ± 3.90 years. Using the standard IGD-20 scale, 96 participants (19%) were classified as potential IGD cases, compared to 408 (80.9%) non-disordered gamers. Males were dominant among the population, constituting 348 (69%) of gamers. Males also played significantly more hours per week [17.8 ±16.75] compared to females [13 ± 17.65]. The majority of gamers (411 (81.5%)) were students, although unemployed adults played for the highest total time [23.9 ± 30.84 hours/week]. Device type used for gaming also significantly (p <0.05) affected the time spent playing. Predictors of IGD included educational level (p< 0.05) and playing hours/week (p< 005). Conversely, no significant associations were found between IGD and gender, age, employment, or sleeping hours. IGD is increasingly being diagnosed among both genders and presents a health challenge for internet users.</p><p><strong>Conclusion: </strong>Establishing gamer profiles and recognizing predictors of IGD is therefore vital for guiding clinical classification and diagnosis of the disease.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sex, Digital Devices, Social Media, and Social Isolation: A Study on Sexual Behavioral During COVID -19 Pandemic. 性、数字设备、社交媒体和社会隔离:COVID -19大流行期间性行为的研究
Q2 Medicine Pub Date : 2021-12-22 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010235
Isabela A Melca, Antonio E Nardi, Lucio L Gonçalves, Rachel M Ferreira, Mariana S K Lins de Padua, Anna L S King

Introduction: Coronavirus (COVID-19) pandemic has caused social and economic damages. People have adapted to a new reality of physical distance.

Objective: The study aimed to assess the use of digital devices and social media, focusing on psychosocial and demographic factors of people´s sexual behavior during the pandemic.

Methods: A total of 1,357 Brazilian adults participated in a cross-sectional online survey. They were recruited through social media to obtain information regarding sexual behavior and the use of digital devices and social media.

Results: Digital devices and social media were used by 38.8% of the participants. Among the group that used technological devices, most claimed to have changed their sexual behavior, with 76.9% consuming more sexual content through movies or series.

Conclusion: In a smaller group, technological resources appeared as an alternative for safer sex, reducing the risks of COVID-19 transmission.

新型冠状病毒(COVID-19)大流行造成了社会和经济损失。人们已经适应了物理距离的新现实。目的:该研究旨在评估数字设备和社交媒体的使用情况,重点关注疫情期间人们性行为的社会心理和人口因素。方法:共有1357名巴西成年人参加了一项横断面在线调查。他们通过社交媒体被招募,以获取有关性行为、数字设备和社交媒体使用情况的信息。结果:38.8%的参与者使用数字设备和社交媒体。在使用科技设备的人群中,大多数人声称改变了他们的性行为,76.9%的人通过电影或电视剧消费了更多的性内容。结论:在一个较小的群体中,技术资源作为安全性行为的替代方案出现,降低了COVID-19传播的风险。
{"title":"Sex, Digital Devices, Social Media, and Social Isolation: A Study on Sexual Behavioral During COVID -19 Pandemic.","authors":"Isabela A Melca,&nbsp;Antonio E Nardi,&nbsp;Lucio L Gonçalves,&nbsp;Rachel M Ferreira,&nbsp;Mariana S K Lins de Padua,&nbsp;Anna L S King","doi":"10.2174/1745017902117010235","DOIUrl":"https://doi.org/10.2174/1745017902117010235","url":null,"abstract":"<p><strong>Introduction: </strong>Coronavirus (COVID-19) pandemic has caused social and economic damages. People have adapted to a new reality of physical distance.</p><p><strong>Objective: </strong>The study aimed to assess the use of digital devices and social media, focusing on psychosocial and demographic factors of people´s sexual behavior during the pandemic.</p><p><strong>Methods: </strong>A total of 1,357 Brazilian adults participated in a cross-sectional online survey. They were recruited through social media to obtain information regarding sexual behavior and the use of digital devices and social media.</p><p><strong>Results: </strong>Digital devices and social media were used by 38.8% of the participants. Among the group that used technological devices, most claimed to have changed their sexual behavior, with 76.9% consuming more sexual content through movies or series.</p><p><strong>Conclusion: </strong>In a smaller group, technological resources appeared as an alternative for safer sex, reducing the risks of COVID-19 transmission.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39929572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Relationship Between Gender and Clinician's Subjective Experience during the Interaction with Psychiatric Patients. 临床医师与精神病患者互动过程中主观体验与性别的关系
Q2 Medicine Pub Date : 2021-12-22 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010190
Federico Dazzi, Laura Fonzi, Mauro Pallagrosi, Marina Duro, Massimo Biondi, Angelo Picardi

Introduction: The clinician's subjective experience can be a valuable element for diagnosis and treatment. A few factors have been recognized that affect it, such as the patient's personality, the severity of psychopathology, and diagnosis. Other factors, such as patient's and clinician's gender, have not been specifically investigated. The aim of this study is to explore the impact of gender differences on the clinician's subjective experience in a large sample of psychiatric patients.

Methods: The study involved 61 psychiatrists and 960 patients attending several inpatient and outpatient psychiatric settings. The clinicians completed the Assessment of Clinician's Subjective Experience (ACSE) questionnaire after observing each patient for the first time.

Results: In multivariate analysis, higher scores on the Difficulty in Attunement (p < 0.001), Engagement (p<0.05), and Impotence (p<0.01) scales were significantly associated with female clinician gender, whereas higher scores on the Tension and Disconfirmation scales were significantly associated with male clinician gender. The scores on all ACSE dimensions were also associated with the severity of psychopathology.

Conclusion: The findings suggest that clinician's gender might affect a clinician's emotional response toward patients. Specific attention to this issue might be useful in clinical situations, not only in terms of promoting gender-balanced teams but also in terms of enhancing self-observation in clinicians evaluating patients for the first time.

临床医生的主观经验对诊断和治疗是有价值的因素。已经认识到影响它的几个因素,如患者的个性、精神病理的严重程度和诊断。其他因素,如患者和临床医生的性别,还没有具体调查。本研究的目的是探讨性别差异对临床医生的主观经验的影响在一个大样本的精神病患者。方法:研究涉及61名精神科医生和960名住院和门诊精神科患者。临床医生在第一次观察每位患者后完成临床医生主观经验评估(ACSE)问卷。结果:在多变量分析中,临床医生在协调困难(p < 0.001)、敬业度(p < 0.001)得分较高。结论:研究结果表明,临床医生的性别可能影响临床医生对患者的情绪反应。在临床情况下,对这个问题的特别关注可能是有用的,不仅在促进性别平衡的团队方面,而且在加强临床医生第一次评估患者的自我观察方面。
{"title":"Relationship Between Gender and Clinician's Subjective Experience during the Interaction with Psychiatric Patients.","authors":"Federico Dazzi,&nbsp;Laura Fonzi,&nbsp;Mauro Pallagrosi,&nbsp;Marina Duro,&nbsp;Massimo Biondi,&nbsp;Angelo Picardi","doi":"10.2174/1745017902117010190","DOIUrl":"https://doi.org/10.2174/1745017902117010190","url":null,"abstract":"<p><strong>Introduction: </strong>The clinician's subjective experience can be a valuable element for diagnosis and treatment. A few factors have been recognized that affect it, such as the patient's personality, the severity of psychopathology, and diagnosis. Other factors, such as patient's and clinician's gender, have not been specifically investigated. The aim of this study is to explore the impact of gender differences on the clinician's subjective experience in a large sample of psychiatric patients.</p><p><strong>Methods: </strong>The study involved 61 psychiatrists and 960 patients attending several inpatient and outpatient psychiatric settings. The clinicians completed the Assessment of Clinician's Subjective Experience (ACSE) questionnaire after observing each patient for the first time.</p><p><strong>Results: </strong>In multivariate analysis, higher scores on the Difficulty in Attunement (p < 0.001), Engagement (p<0.05), and Impotence (p<0.01) scales were significantly associated with female clinician gender, whereas higher scores on the Tension and Disconfirmation scales were significantly associated with male clinician gender. The scores on all ACSE dimensions were also associated with the severity of psychopathology.</p><p><strong>Conclusion: </strong>The findings suggest that clinician's gender might affect a clinician's emotional response toward patients. Specific attention to this issue might be useful in clinical situations, not only in terms of promoting gender-balanced teams but also in terms of enhancing self-observation in clinicians evaluating patients for the first time.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of Life and Clinical Correlates in Adults with Social Phobia: A Scoping Review. 成人社交恐惧症患者的生活质量和临床相关因素:一项范围综述。
Q2 Medicine Pub Date : 2021-12-22 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010224
Hui Miin Lau, Kai Samuel Sim, Qian Hui Chew, Kang Sim

Objective: In light of the substantial clinical and societal burden of social phobia (SP) and impact on the sense of well-being of affected individuals, we sought to summarise extant data related to quality of life and relevant correlates in adults with SP to distill clinical profiles for earlier identification and appropriate management.

Methods: A scoping review was carried out on studies examining quality of life in adults with SP and clinical correlates within different settings. PubMed/Medline and Web of Science databases were searched for relevant articles beginning from database inception until May 2021.

Results: A total of 25 papers were included. Most of the studies (92%) were cross sectional in nature (80%), conducted in the West (92%), and within clinic or community settings (88%). Patients with comorbid psychiatric conditions, and undergraduate students reported higher rates of SP compared with community population. Significant correlates of SP included demographic (such as females, younger age, living alone, fewer years of education, unemployment) and clinical factors (such as family history of anxiety disorders, suicidal ideas, avoidant personality features). SP was widely associated with decreased QoL involving several domains and especially related to complexity, greater number of feared or trigger situations, and comorbid medical and psychiatric conditions.

Conclusion: SP is not uncommon within clinical, and undergraduate populations, and has a significantly negative impact on quality of life. Awareness of its associated clinical profiles allows better identification and overall management of this condition including improvement in QoL.

目的:鉴于社交恐惧症(SP)的临床和社会负担以及对受影响个体幸福感的影响,我们试图总结现有的与生活质量相关的数据,以及与成人社交恐惧症相关的相关因素,以提取临床资料,以便早期识别和适当管理。方法:对不同环境下SP成人生活质量和临床相关性的研究进行了范围审查。检索PubMed/Medline和Web of Science数据库从数据库建立到2021年5月的相关文章。结果:共纳入25篇论文。大多数研究(92%)本质上是横断面的(80%),在西方进行(92%),在诊所或社区环境中进行(88%)。与社区人群相比,伴有精神疾病的患者和大学生的SP发生率较高。SP的显著相关因素包括人口统计学(如女性、年龄较小、独居、受教育年限较短、失业)和临床因素(如焦虑障碍家族史、自杀念头、回避型人格特征)。SP与生活质量下降广泛相关,涉及多个领域,特别是与复杂性、更多的恐惧或触发情况以及合并症和精神状况有关。结论:SP在临床和大学生人群中并不少见,并对生活质量有显著的负面影响。了解其相关的临床特征可以更好地识别和全面管理这种疾病,包括改善生活质量。
{"title":"Quality of Life and Clinical Correlates in Adults with Social Phobia: A Scoping Review.","authors":"Hui Miin Lau,&nbsp;Kai Samuel Sim,&nbsp;Qian Hui Chew,&nbsp;Kang Sim","doi":"10.2174/1745017902117010224","DOIUrl":"https://doi.org/10.2174/1745017902117010224","url":null,"abstract":"<p><strong>Objective: </strong>In light of the substantial clinical and societal burden of social phobia (SP) and impact on the sense of well-being of affected individuals, we sought to summarise extant data related to quality of life and relevant correlates in adults with SP to distill clinical profiles for earlier identification and appropriate management.</p><p><strong>Methods: </strong>A scoping review was carried out on studies examining quality of life in adults with SP and clinical correlates within different settings. PubMed/Medline and Web of Science databases were searched for relevant articles beginning from database inception until May 2021.</p><p><strong>Results: </strong>A total of 25 papers were included. Most of the studies (92%) were cross sectional in nature (80%), conducted in the West (92%), and within clinic or community settings (88%). Patients with comorbid psychiatric conditions, and undergraduate students reported higher rates of SP compared with community population. Significant correlates of SP included demographic (such as females, younger age, living alone, fewer years of education, unemployment) and clinical factors (such as family history of anxiety disorders, suicidal ideas, avoidant personality features). SP was widely associated with decreased QoL involving several domains and especially related to complexity, greater number of feared or trigger situations, and comorbid medical and psychiatric conditions.</p><p><strong>Conclusion: </strong>SP is not uncommon within clinical, and undergraduate populations, and has a significantly negative impact on quality of life. Awareness of its associated clinical profiles allows better identification and overall management of this condition including improvement in QoL.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association between Estimated Cardiorespiratory Fitness and Depression among Middle-income Country Adults: Evidence from National Health Survey. 中等收入国家成年人的估计心肺功能与抑郁之间的关系:来自全国健康调查的证据
Q2 Medicine Pub Date : 2021-12-22 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010198
Eduardo Lattari, Andreza Jesus Costa Pascouto, Bruno Ribeiro Ramalho Oliveira, Livia Soares Silva, Aldair José Oliveira, Sérgio Machado, Geraldo Albuquerque Maranhao Neto

Objective: This study assessed the relationship between cardiorespiratory fitness (CRF) and depression in adults.

Methods: A total of 52,611 individuals aged between 18-59 years old were evaluated for symptoms of depression and CRF. The presence of depressive symptoms was self-report through the Patient Health Questionnaire (PHQ-9), and the CRF was predicted from a non-exercise equation. The association between CRF and the presence of depression was determined by crude and multivariable-adjusted logistic regressions.

Results: The associations were identified between symptoms of depression and CRF in both unadjusted and adjusted models. After adjusting for age categories, sex, body mass index categories, educational level, marital status, smoking, and alcohol use, the individuals with moderate CRF had 18% lower odds of depression (OR: 0.82, CI 95%: 0.71 - 0.95) compared to individuals with low CRF.

Conclusion: Depressive symptoms are inversely related to CRF levels in adults.

目的:本研究评估了成年人心肺功能(CRF)与抑郁症之间的关系:本研究评估了成年人心肺功能(CRF)与抑郁症之间的关系:共对 52,611 名年龄在 18-59 岁之间的人进行了抑郁症状和 CRF 评估。抑郁症状是通过患者健康问卷(PHQ-9)自我报告的,而CRF则是通过非运动方程预测的。通过粗略和多变量调整逻辑回归确定 CRF 与抑郁症状之间的关系:结果:在未调整模型和调整模型中,均发现了抑郁症状与 CRF 之间的关联。在对年龄、性别、体重指数、教育程度、婚姻状况、吸烟和酗酒等因素进行调整后,与低CRF的人相比,中度CRF的人患抑郁症的几率要低18%(OR:0.82,CI 95%:0.71 - 0.95):结论:抑郁症状与成年人的 CRF 水平成反比。
{"title":"Association between Estimated Cardiorespiratory Fitness and Depression among Middle-income Country Adults: Evidence from National Health Survey.","authors":"Eduardo Lattari, Andreza Jesus Costa Pascouto, Bruno Ribeiro Ramalho Oliveira, Livia Soares Silva, Aldair José Oliveira, Sérgio Machado, Geraldo Albuquerque Maranhao Neto","doi":"10.2174/1745017902117010198","DOIUrl":"10.2174/1745017902117010198","url":null,"abstract":"<p><strong>Objective: </strong>This study assessed the relationship between cardiorespiratory fitness (CRF) and depression in adults.</p><p><strong>Methods: </strong>A total of 52,611 individuals aged between 18-59 years old were evaluated for symptoms of depression and CRF. The presence of depressive symptoms was self-report through the Patient Health Questionnaire (PHQ-9), and the CRF was predicted from a non-exercise equation. The association between CRF and the presence of depression was determined by crude and multivariable-adjusted logistic regressions.</p><p><strong>Results: </strong>The associations were identified between symptoms of depression and CRF in both unadjusted and adjusted models. After adjusting for age categories, sex, body mass index categories, educational level, marital status, smoking, and alcohol use, the individuals with moderate CRF had 18% lower odds of depression (OR: 0.82, CI 95%: 0.71 - 0.95) compared to individuals with low CRF.</p><p><strong>Conclusion: </strong>Depressive symptoms are inversely related to CRF levels in adults.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39627052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia Underwent Hematopoietic Stem Cell Transplantation 接受造血干细胞移植的β-地中海贫血患者健康相关生活质量的系统评价和荟萃分析
Q2 Medicine Pub Date : 2021-12-08 DOI: 10.2174/17450179-v17-e211208-cpemh-2021-ht2-1910-4
O. Mulas, Ilaria Pili, Marco Sanna, Giorgio La Nasa
β-Thalassemia major (β-TM) represents one of the most important hemoglobinopathies worldwide. Remarkable improvements have been achieved in supportive therapy, based on blood transfusions and iron chelation, and nowadays this approach is capable to assure a long life in these patients in industrialized countries. The only curative treatment is represented by hematopoietic stem cell transplantation (HSCT). However, this treatment may be burdened by deterioration in the Health-Related Quality of Life (HRQoL). The aim of this paper was to evaluate with a systematic review and meta-analysis the role of HRQoL in transplanted β-TM patients. PubMed database, Web of Science and Scopus were systematically searched for studies published between January 1st, 2000 to September, 2020; the following terms were entered in the database queries: β-thalassemia, HRQoL and HSCT. The study was carried out according to the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) statement. We identified a total of 33 potential studies. Among these, 10 were finally considered in the systematic review and 5 in the meta-analysis. Overall, good scores in the principal domains of HRQoL were reported by transplanted patients. These data were confirmed by results of meta-analysis that showed significant difference between transplanted and β-TM patients treated with a conventional therapy in Physical an Emotional Function dimension, with a medium effect size (d=0.65, (95% CI (0.29-1.02) z = 3.52, p =0.0004, I2=75% and d=0.59, (95% CI (0.43-0.76) z = 6.99, p <0.00001, I2=0% respectively). HRQoL is generally good in β-TM transplanted patients and may give a significant contribute the difficult choice whether transplant or not a β-TM patient treated with conventional therapy.
β-地中海贫血(β-TM)是世界上最重要的血红蛋白病之一。在以输血和铁螯合为基础的支持治疗方面已经取得了显著的进步,如今这种方法能够确保工业化国家这些患者的长寿。唯一的治愈方法是造血干细胞移植(HSCT)。然而,这种治疗可能会因健康相关生活质量(HRQoL)的恶化而负担过重。本文的目的是通过系统回顾和荟萃分析来评估HRQoL在移植β-TM患者中的作用。系统检索PubMed数据库、Web of Science和Scopus数据库2000年1月1日至2020年9月间发表的研究;在数据库查询中输入以下术语:β-地中海贫血、HRQoL和HSCT。本研究按照系统和荟萃分析首选报告项目(PRISMA)声明进行。我们总共确定了33项潜在的研究。其中10个最终纳入系统评价,5个纳入meta分析。总的来说,移植患者在HRQoL的主要领域获得了良好的评分。meta分析结果证实了这些数据,移植β-TM患者与常规治疗的β-TM患者在生理和情绪功能维度上存在显著差异,具有中等效应量(d=0.65, 95% CI (0.29-1.02) z = 3.52, p =0.0004, I2=75%, d=0.59, 95% CI (0.43-0.76) z = 6.99, p <0.00001, I2=0%)。β-TM移植患者的HRQoL普遍较好,这可能是β-TM患者接受常规治疗是否移植的困难选择的重要因素。
{"title":"Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia Underwent Hematopoietic Stem Cell Transplantation","authors":"O. Mulas, Ilaria Pili, Marco Sanna, Giorgio La Nasa","doi":"10.2174/17450179-v17-e211208-cpemh-2021-ht2-1910-4","DOIUrl":"https://doi.org/10.2174/17450179-v17-e211208-cpemh-2021-ht2-1910-4","url":null,"abstract":"\u0000 \u0000 β-Thalassemia major (β-TM) represents one of the most important hemoglobinopathies worldwide. Remarkable improvements have been achieved in supportive therapy, based on blood transfusions and iron chelation, and nowadays this approach is capable to assure a long life in these patients in industrialized countries. The only curative treatment is represented by hematopoietic stem cell transplantation (HSCT). However, this treatment may be burdened by deterioration in the Health-Related Quality of Life (HRQoL). The aim of this paper was to evaluate with a systematic review and meta-analysis the role of HRQoL in transplanted β-TM patients.\u0000 \u0000 \u0000 \u0000 PubMed database, Web of Science and Scopus were systematically searched for studies published between January 1st, 2000 to September, 2020; the following terms were entered in the database queries: β-thalassemia, HRQoL and HSCT. The study was carried out according to the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) statement.\u0000 \u0000 \u0000 \u0000 We identified a total of 33 potential studies. Among these, 10 were finally considered in the systematic review and 5 in the meta-analysis. Overall, good scores in the principal domains of HRQoL were reported by transplanted patients. These data were confirmed by results of meta-analysis that showed significant difference between transplanted and β-TM patients treated with a conventional therapy in Physical an Emotional Function dimension, with a medium effect size (d=0.65, (95% CI (0.29-1.02) z = 3.52, p =0.0004, I2=75% and d=0.59, (95% CI (0.43-0.76) z = 6.99, p <0.00001, I2=0% respectively).\u0000 \u0000 \u0000 \u0000 HRQoL is generally good in β-TM transplanted patients and may give a significant contribute the difficult choice whether transplant or not a β-TM patient treated with conventional therapy.\u0000","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82058009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Comparative Study of the Communication Profile of Typically Developing Children and Children with Receptive-Expressive Language Disorders: A Parental Perceptive. 正常发育儿童与接受-表达性语言障碍儿童交流特征的比较研究:父母的感知。
Q2 Medicine Pub Date : 2021-12-01 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010177
Aiswarya L Varghese, Chinnu Thomas, Megha Mohan, Sudhin Karuppali

Background: Parental concerns pertaining to communication abilities are essential as it does aid in the identification of the children at risk of physical and mental health problems.

Objectives: The current study followed a cross sectional study design. The study focussed on developing a questionnaire targeting the parental concerns in Typically developing (TD) children and children with Receptive-Expressive Language Disorders (CWRELD) between 3.7 and 6.6 years of age; to administer the developed questionnaire on parents of TD children and CWRELD; and to analyse and compare the concerns faced by parents of TD children and CWRELD across 3.7 and 6.6 years of age.

Methods: Fifty-one parents of TD children and 51 parents of CWRELD participated in the study. The study was carried out in three phases- Phase I included the development and validation of questionnaire; Phase II included data collection using the developed questionnaire; and Phase III included performing statistical analysis. Descriptive statistics was done to determine the mean and standard deviation (SD) for both the TD and CWRELD groups.

Results: The results revealed that the concerns exhibited by parents of CWRELD were significantly higher than that of parents of TD children. Chi square results indicated statistically significant findings across all the domains between TD children and CWRELD (p<0.05).

Conclusion: The developed questionnaire can be used in clinical settings to help track parental concerns which may aid in the early identification of children at risk of various communication disorders. Additionally, this questionnaire may be considered for monitoring parental concerns throughout the course of the intervention program.

背景:父母对沟通能力的关注是必不可少的,因为它有助于确定有身心健康问题风险的儿童。目的:本研究采用横断面研究设计。本研究针对3.7 ~ 6.6岁的典型发育(TD)儿童和接受性表达语言障碍(creworld)儿童的父母关注问题,设计了一份问卷;管理已编制的有关残疾儿童家长及幼儿护理署的问卷;并分析和比较3.7岁和6.6岁的TD儿童和creworld儿童的父母所面临的问题。方法:51名TD患儿家长和51名crwld患儿家长参与研究。研究分三个阶段进行:第一阶段包括编制和验证问卷;第二阶段包括使用开发的问卷收集数据;第三阶段包括统计分析。进行描述性统计以确定TD组和creworld组的平均值和标准差(SD)。结果:研究结果显示,cwrld患儿家长的担忧程度显著高于TD患儿家长。卡方结果显示,在TD儿童和CWRELD儿童之间的所有领域都有统计学意义的发现。结论:开发的问卷可以在临床环境中使用,帮助跟踪父母的担忧,有助于早期识别各种沟通障碍风险的儿童。此外,本问卷也可用于监测家长在整个干预过程中所关心的问题。
{"title":"A Comparative Study of the Communication Profile of Typically Developing Children and Children with Receptive-Expressive Language Disorders: A Parental Perceptive.","authors":"Aiswarya L Varghese,&nbsp;Chinnu Thomas,&nbsp;Megha Mohan,&nbsp;Sudhin Karuppali","doi":"10.2174/1745017902117010177","DOIUrl":"https://doi.org/10.2174/1745017902117010177","url":null,"abstract":"<p><strong>Background: </strong>Parental concerns pertaining to communication abilities are essential as it does aid in the identification of the children at risk of physical and mental health problems.</p><p><strong>Objectives: </strong>The current study followed a cross sectional study design. The study focussed on developing a questionnaire targeting the parental concerns in Typically developing (TD) children and children with Receptive-Expressive Language Disorders (CWRELD) between 3.7 and 6.6 years of age; to administer the developed questionnaire on parents of TD children and CWRELD; and to analyse and compare the concerns faced by parents of TD children and CWRELD across 3.7 and 6.6 years of age.</p><p><strong>Methods: </strong>Fifty-one parents of TD children and 51 parents of CWRELD participated in the study. The study was carried out in three phases- Phase I included the development and validation of questionnaire; Phase II included data collection using the developed questionnaire; and Phase III included performing statistical analysis. Descriptive statistics was done to determine the mean and standard deviation (SD) for both the TD and CWRELD groups.</p><p><strong>Results: </strong>The results revealed that the concerns exhibited by parents of CWRELD were significantly higher than that of parents of TD children. Chi square results indicated statistically significant findings across all the domains between TD children and CWRELD (p<0.05).</p><p><strong>Conclusion: </strong>The developed questionnaire can be used in clinical settings to help track parental concerns which may aid in the early identification of children at risk of various communication disorders. Additionally, this questionnaire may be considered for monitoring parental concerns throughout the course of the intervention program.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39763481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Qualitative Study Regarding COVID-19 Inpatient Family Caregivers' Need for Supportive Care. 新型冠状病毒肺炎住院患者家庭护理人员支持性护理需求的定性研究
Q2 Medicine Pub Date : 2021-11-19 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010161
Angelo Picardi, Marco Miniotti, Paolo Leombruni, Antonella Gigantesco

Background: Family caregivers of COVID-19 inpatients are exposed to multiple sources of distress. These include not only losing friends, colleagues and members of the family, but also the fear of possible losses in sociality, finances and, impoverished communication with sick family members and health care providers.

Objective: This study describes the psychological experience of COVID-19 inpatient family caregivers to highlight the main sources of distress, issues, concerns and unmet needs.

Methods: Two focus groups were independently organized with COVID-19 inpatient family caregivers and health care personnel of COVID-19 wards in order to highlight family caregivers' practical and psychological burden and related needs. A thematic analysis was conducted to analyze the data.

Results: Family caregivers mentioned they needed more information about the patient's condition with more attention being paid to their own emotional state. Feelings of impotence, concerns about how to deal with patient's discharge, significant psychological distress, and anxiety were frequently reported by study participants.

Conclusion: Study findings suggest the need to strengthen the assistance of COVID-19 patient family caregivers. In the pandemic scenario, family caregivers might represent a crucial resource, which can guarantee rapid discharges, support home health care and thus relieve pressure on hospital systems.

背景:COVID-19住院患者的家庭照顾者面临多种痛苦来源。这不仅包括失去朋友、同事和家庭成员,还包括担心可能失去社交、财务以及与生病的家庭成员和卫生保健提供者的沟通困难。目的:本研究描述新冠肺炎住院家庭护理人员的心理体验,以突出困扰的主要来源、问题、担忧和未满足的需求。方法:以新冠肺炎住院家庭护理人员和新冠肺炎病房医护人员为对象,独立组织2个焦点小组,突出家庭护理人员的现实负担和心理负担及相关需求。对数据进行了专题分析。结果:家庭照顾者表示他们需要更多关于患者病情的信息,更关注他们自己的情绪状态。研究参与者经常报告阳痿的感觉、对如何处理病人出院的担忧、严重的心理困扰和焦虑。结论:研究结果提示需要加强对COVID-19患者家庭护理人员的帮助。在大流行的情况下,家庭护理人员可能是一种关键资源,可以保证快速出院,支持家庭卫生保健,从而减轻医院系统的压力。
{"title":"A Qualitative Study Regarding COVID-19 Inpatient Family Caregivers' Need for Supportive Care.","authors":"Angelo Picardi,&nbsp;Marco Miniotti,&nbsp;Paolo Leombruni,&nbsp;Antonella Gigantesco","doi":"10.2174/1745017902117010161","DOIUrl":"https://doi.org/10.2174/1745017902117010161","url":null,"abstract":"<p><strong>Background: </strong>Family caregivers of COVID-19 inpatients are exposed to multiple sources of distress. These include not only losing friends, colleagues and members of the family, but also the fear of possible losses in sociality, finances and, impoverished communication with sick family members and health care providers.</p><p><strong>Objective: </strong>This study describes the psychological experience of COVID-19 inpatient family caregivers to highlight the main sources of distress, issues, concerns and unmet needs.</p><p><strong>Methods: </strong>Two focus groups were independently organized with COVID-19 inpatient family caregivers and health care personnel of COVID-19 wards in order to highlight family caregivers' practical and psychological burden and related needs. A thematic analysis was conducted to analyze the data.</p><p><strong>Results: </strong>Family caregivers mentioned they needed more information about the patient's condition with more attention being paid to their own emotional state. Feelings of impotence, concerns about how to deal with patient's discharge, significant psychological distress, and anxiety were frequently reported by study participants.</p><p><strong>Conclusion: </strong>Study findings suggest the need to strengthen the assistance of COVID-19 patient family caregivers. In the pandemic scenario, family caregivers might represent a crucial resource, which can guarantee rapid discharges, support home health care and thus relieve pressure on hospital systems.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39777526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
The Prevalence of Addiction to Social Network Among Students in Iran and its Factors Related: A Study Conducted in 2020. 伊朗学生社交网络成瘾的流行程度及其相关因素:一项于2020年进行的研究
Q2 Medicine Pub Date : 2021-11-19 eCollection Date: 2021-01-01 DOI: 10.2174/1745017902117010170
Hoorieh Rahiminia, Hamid Soori, Mahdi Jafari, Soheila Khodakarim

Background: In the present era, the prevalence of addiction to social networks has shown that many users, including students, are detaching from the real world. Therefore, this study aims to estimate the prevalence of addiction to the social networks among students in Iran and its related factors.

Methods: This is a cross-sectional study conducted in 2020 on 1000 students in Shahid Beheshti University of Medical Sciences, Tehran, Iran. The data collection tool was a standardized questionnaire about addiction to the social networks distributed online among students. Statistical data were analyzed using Stata software version 14.

Results: Generally, 462 students (44%) had addiction to social networks, of which 449 (90.04%) had slight addiction and 13 (9.96%) had severe addiction. The results showed that age (p = 0.001), type of disciplines in the treatment-related subgroup (p = 0.03) and using nerve medicine (p = 0.0001) had significant relationships with addiction to social networks.

Conclusion: Considering that a high number of students in the present study are at high risk of addiction, it is suggested that educational programs should be implemented to improve the knowledge of parents and students for optimal use of social networks and raise awareness of the harmful consequences of addiction.

背景:在当今时代,社交网络成瘾的普遍性表明,包括学生在内的许多用户正在脱离现实世界。因此,本研究旨在估计伊朗学生对社交网络成瘾的患病率及其相关因素。方法:这是一项2020年对伊朗德黑兰Shahid Beheshti医学科学大学1000名学生进行的横断面研究。数据收集工具是一份关于学生对在线社交网络成瘾的标准化问卷。使用Stata软件14版对统计数据进行分析。结果:总体而言,462名学生(44%)有社交网络成瘾,其中449名(90.04%)有轻微成瘾,13名(9.96%)有严重成瘾。结果显示,年龄(p=0.001)、治疗相关亚组的学科类型(p=0.03)和使用神经药物(p=0.0001)与社交网络成瘾有显著关系。结论:考虑到本研究中大量学生有成瘾的高风险,建议实施教育计划,提高家长和学生对社交网络最佳使用的知识,并提高对成瘾有害后果的认识。
{"title":"The Prevalence of Addiction to Social Network Among Students in Iran and its Factors Related: A Study Conducted in 2020.","authors":"Hoorieh Rahiminia,&nbsp;Hamid Soori,&nbsp;Mahdi Jafari,&nbsp;Soheila Khodakarim","doi":"10.2174/1745017902117010170","DOIUrl":"10.2174/1745017902117010170","url":null,"abstract":"<p><strong>Background: </strong>In the present era, the prevalence of addiction to social networks has shown that many users, including students, are detaching from the real world. Therefore, this study aims to estimate the prevalence of addiction to the social networks among students in Iran and its related factors.</p><p><strong>Methods: </strong>This is a cross-sectional study conducted in 2020 on 1000 students in Shahid Beheshti University of Medical Sciences, Tehran, Iran. The data collection tool was a standardized questionnaire about addiction to the social networks distributed online among students. Statistical data were analyzed using Stata software version 14.</p><p><strong>Results: </strong>Generally, 462 students (44%) had addiction to social networks, of which 449 (90.04%) had slight addiction and 13 (9.96%) had severe addiction. The results showed that age (p = 0.001), type of disciplines in the treatment-related subgroup (p = 0.03) and using nerve medicine (p = 0.0001) had significant relationships with addiction to social networks.</p><p><strong>Conclusion: </strong>Considering that a high number of students in the present study are at high risk of addiction, it is suggested that educational programs should be implemented to improve the knowledge of parents and students for optimal use of social networks and raise awareness of the harmful consequences of addiction.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39777527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of Tyrosine Kinase Inhibitors (TKIs) in monotherapy and with add-on treatments on Health-related Quality of Life of People with Chronic Myeloid Leukemia: a systematic review of Randomized-Controlled Trials. 酪氨酸激酶抑制剂(TKIs)在单药治疗和附加治疗中对慢性髓系白血病患者健康相关生活质量的影响:随机对照试验的系统回顾
Q2 Medicine Pub Date : 2021-11-18 DOI: 10.2174/17450179-v17-e211118-cpemh-2021-ht2-1910-12
A. E. Nardi, F. Sancassiani, Vanessa Barrui, G. Kalcev, V. Uras, Giulia Meloni, Luigi Marongiu, Giorgio Tamburini, Alberto Maleci, Laiana A. Quagliato, Giorgio La Nasa, M. Carta
The era of establishing tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) changed the outcome and the course of this life-threatening malignancy. People suffering from CML have now a better prognosis and a longer life expectancy by the development of TKIs, even if it requires long term—often lifelong— treatments that are nonetheless associated with improved Health-related Quality of life (HRQoL). However, data on the effects of TKIs on HRQoL are not always systematic: sometimes they were obtained by studies different from RCTs, or without a clear definition of what HRQoL is. The main purpose of this systematic review is to summarize all randomized-controlled trials (RCTs) including HRQoL as main or secondary outcome in patients with CML treated with TKIs or with TKIs plus an add-on treatment. Systematic review by searching for relevant papers in PubMed/Medline and Web of Science with the following keywords: “quality of life” OR “health-related quality of life” OR “QoL” OR “HRQoL” OR “H-QoL” AND “chronic myeloid leukemia”. Interval was set from January 2000 to December 2020. 40 papers were identified through the search. Out of them, 7 RCTs were included. All the studies used standardized measures to assess HRQoL, even not always specific for CML. 5 RCTs randomized subjects to 2 or 3 arms to evaluate the effects of TKIs of the first, second and third generation in monotherapy. 2 RCTs randomized subjects to TKI therapy plus an add-on treatment versus TKI therapy as usual. The results of all these trials were examined and discussed. All the included RCTs pointed out significant findings about the positive effects of TKIs on HRQoL of people with CML, both when they were used in monotherapy or, notably, with an add-on treatment to enhance TKIs effects.
建立酪氨酸激酶抑制剂(TKIs)治疗慢性髓性白血病(CML)的时代改变了这种危及生命的恶性肿瘤的结局和病程。由于tki的发展,患有CML的人现在有更好的预后和更长的预期寿命,即使它需要长期(通常是终身)治疗,但与健康相关的生活质量(HRQoL)的改善有关。然而,tki对HRQoL影响的数据并不总是系统的:有时这些数据是通过与随机对照试验不同的研究获得的,或者没有明确定义HRQoL是什么。本系统综述的主要目的是总结所有随机对照试验(RCTs),包括HRQoL作为CML患者接受TKIs治疗或TKIs加附加治疗的主要或次要结局。系统检索PubMed/Medline和Web of Science相关论文,关键词:“生活质量”或“健康相关生活质量”或“QoL”或“HRQoL”或“H-QoL”和“慢性髓性白血病”。时间间隔为2000年1月至2020年12月。通过搜索确定了40篇论文。其中纳入7项随机对照试验。所有的研究都使用标准化的方法来评估HRQoL,即使并不总是针对CML。5项随机对照试验将受试者随机分为2或3组,以评估第一代、第二代和第三代TKIs在单药治疗中的效果。2项随机对照试验将受试者随机分为TKI治疗加附加治疗组和常规TKI治疗组。对所有这些试验的结果进行了检验和讨论。所有纳入的随机对照试验都指出了TKIs对CML患者HRQoL的积极影响的显著发现,无论是在单药治疗中使用,还是在附加治疗中使用以增强TKIs的效果。
{"title":"The effects of Tyrosine Kinase Inhibitors (TKIs) in monotherapy and with add-on treatments on Health-related Quality of Life of People with Chronic Myeloid Leukemia: a systematic review of Randomized-Controlled Trials.","authors":"A. E. Nardi, F. Sancassiani, Vanessa Barrui, G. Kalcev, V. Uras, Giulia Meloni, Luigi Marongiu, Giorgio Tamburini, Alberto Maleci, Laiana A. Quagliato, Giorgio La Nasa, M. Carta","doi":"10.2174/17450179-v17-e211118-cpemh-2021-ht2-1910-12","DOIUrl":"https://doi.org/10.2174/17450179-v17-e211118-cpemh-2021-ht2-1910-12","url":null,"abstract":"\u0000 \u0000 The era of establishing tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) changed the outcome and the course of this life-threatening malignancy. People suffering from CML have now a better prognosis and a longer life expectancy by the development of TKIs, even if it requires long term—often lifelong— treatments that are nonetheless associated with improved Health-related Quality of life (HRQoL). However, data on the effects of TKIs on HRQoL are not always systematic: sometimes they were obtained by studies different from RCTs, or without a clear definition of what HRQoL is. The main purpose of this systematic review is to summarize all randomized-controlled trials (RCTs) including HRQoL as main or secondary outcome in patients with CML treated with TKIs or with TKIs plus an add-on treatment.\u0000 \u0000 \u0000 \u0000 Systematic review by searching for relevant papers in PubMed/Medline and Web of Science with the following keywords: “quality of life” OR “health-related quality of life” OR “QoL” OR “HRQoL” OR “H-QoL” AND “chronic myeloid leukemia”. Interval was set from January 2000 to December 2020.\u0000 \u0000 \u0000 \u0000 40 papers were identified through the search. Out of them, 7 RCTs were included. All the studies used standardized measures to assess HRQoL, even not always specific for CML. 5 RCTs randomized subjects to 2 or 3 arms to evaluate the effects of TKIs of the first, second and third generation in monotherapy. 2 RCTs randomized subjects to TKI therapy plus an add-on treatment versus TKI therapy as usual. The results of all these trials were examined and discussed.\u0000 \u0000 \u0000 \u0000 All the included RCTs pointed out significant findings about the positive effects of TKIs on HRQoL of people with CML, both when they were used in monotherapy or, notably, with an add-on treatment to enhance TKIs effects.\u0000","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91336408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical Practice and Epidemiology in Mental Health
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1