M. Stupar, V. Vidović, V. Baltic, Ljuba Štrbac, D. Lukač
We are starting to understand the fundamental biological processes which underlie the DNA physical properties. Of particular importance is the field of epigenetics, which literally means 'outside conventional genetics', now used to describe the study of stable alterations in gene expression potential that arise during development and cell proliferation. Epigenetic changes are modifications of DNA, which occur without any alteration in the DNA sequence. Modern directions in the field of epigenetic research aimed to decipher the epigenetic signals that give stem cells their unique ability to self-renew and differentiate into different types. Stem cell-based regenerative medicine holds great promise for repair of diseased tissue. If epigenetic process are reversible, than there is the ability to cure cancer through stem cell therapy.
{"title":"Epigenetic DNA changes and stem cells therapy","authors":"M. Stupar, V. Vidović, V. Baltic, Ljuba Štrbac, D. Lukač","doi":"10.2298/AOO1301024S","DOIUrl":"https://doi.org/10.2298/AOO1301024S","url":null,"abstract":"We are starting to understand the fundamental biological processes which underlie the DNA physical properties. Of particular importance is the field of epigenetics, which literally means 'outside conventional genetics', now used to describe the study of stable alterations in gene expression potential that arise during development and cell proliferation. Epigenetic changes are modifications of DNA, which occur without any alteration in the DNA sequence. Modern directions in the field of epigenetic research aimed to decipher the epigenetic signals that give stem cells their unique ability to self-renew and differentiate into different types. Stem cell-based regenerative medicine holds great promise for repair of diseased tissue. If epigenetic process are reversible, than there is the ability to cure cancer through stem cell therapy.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"24-27"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1301024S","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bacterial flora on the surface of oral squamous cell carcinoma","authors":"M. Čanković, M. Bokor-Bratić, J. Loncar, Jovan Marinoski, M. Ilić","doi":"10.2298/AOO1302062C","DOIUrl":"https://doi.org/10.2298/AOO1302062C","url":null,"abstract":"4 patients (13.3%), mucocele in 4 patients (13.3%), capillary mucous haemangioma in 3 patients (10.0%), mucosal polyp in 3 patients (10.0%), chronic nonspecific sialadenitis in 3 patients (10.0%), mucosal papilloma in 2 patients (6.7%), retention cyst in 2 patients (6.7%), and subacute nonspecific inflammation in 1 patient (3.3%).","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"62-64"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1302062C","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ljiljana Tadić-Latinović, Aleksandra Salapura-Dugonjic, Ž. Eri, S. Knežević-Ušaj, Milana Panjković, L. Amidžić, I. Baroš, B. Jakovljević
www.onk.ns.ac.rs/Archive Vol 21, No. 3-4, December 2013 INTRODUCTION Lung cancer is one of the leading causes of death throughout the world. Approximately one million people, 850,000 men and 330,000 women, die of lung cancer per year (1). Despite some advances in the diagnosis and treatment of lung cancer in the last several decades, the prognosis of lung cancer remains poor. The overall 5-year survival rate of lung cancer is approximately 12.4% of all newly detected cases in the world, and <9% in developing countries (2, 3). The MMP family comprises 23 human enzymes that traditionally have long been associated with cancer invasion and metastasis because of their ability to degrade the extracellular matrix. However, recent studies have showed that the roles of MMPs in tumour development and metastasis are much more complex than was originally envisioned. In vitro and animal studies have demonstrated that MMPs are also the key mediators of growth factor activation, bioavailability and receptor signalling, cell adhesion and motility, apoptosis and survival mechanisms, angiogenesis, and inflammatory responses and immune surveillance (4). Matrix metalloproteinases (MMP) are the group of enzymes responsible for degradation of certain extracellular matrix proteins such as collagen, proteoglycan, elastin, laminin and fibronectin. Malignant diseases are accompanied with higher expression of matrix metalloproteinases and lower concentrations of the tissue inhibitors of matrix metalloproteinases (TIMP), also resulting in an increased proteolytic activity. The presence of matrix metalloproteinases was discovered on the surface of invasive tumor cells (5). Degradation of the basal membrane and extracellular matrix presents the key step in the process of intravasation and extravasation of tumor cells (6). MMP-9 belongs to the gelatinases group, synthesized by keratinocytes, monocytes, alveolar macrophages, polymorphonuclear neutrophil granulocytes, and in many cancer cells. Tumor invasion is a multi-phase process in which the cell motility is associated with controlled proteolysis and includes interaction between tumor cells and extracellular matrix. During the invasion process, malignant tumor cells are detached from the primary tumor, migrate through structural barriers such as the basal membrane and surrounding extracellular matrix rich in collagen. Degradation of the stromal extracellular matrix is also considered one of the key steps in the process of tumor angiogenesis (7). It has been proved that the activity of matrix metalloproteinases is necessary for increased motility of epithelial cells, as well as for the growth of metastatic deposits. Research has confirmed that MMP-2 and MMP-9 have an exceptionally significant role in metastasizing, due to their ability to degrade type IV The prognostic value of mmp-9 expression in lung adenocarcinoma
{"title":"The prognostic value of MMP-9 expression in lung adenocarcinoma","authors":"Ljiljana Tadić-Latinović, Aleksandra Salapura-Dugonjic, Ž. Eri, S. Knežević-Ušaj, Milana Panjković, L. Amidžić, I. Baroš, B. Jakovljević","doi":"10.2298/AOO1304109T","DOIUrl":"https://doi.org/10.2298/AOO1304109T","url":null,"abstract":"www.onk.ns.ac.rs/Archive Vol 21, No. 3-4, December 2013 INTRODUCTION Lung cancer is one of the leading causes of death throughout the world. Approximately one million people, 850,000 men and 330,000 women, die of lung cancer per year (1). Despite some advances in the diagnosis and treatment of lung cancer in the last several decades, the prognosis of lung cancer remains poor. The overall 5-year survival rate of lung cancer is approximately 12.4% of all newly detected cases in the world, and <9% in developing countries (2, 3). The MMP family comprises 23 human enzymes that traditionally have long been associated with cancer invasion and metastasis because of their ability to degrade the extracellular matrix. However, recent studies have showed that the roles of MMPs in tumour development and metastasis are much more complex than was originally envisioned. In vitro and animal studies have demonstrated that MMPs are also the key mediators of growth factor activation, bioavailability and receptor signalling, cell adhesion and motility, apoptosis and survival mechanisms, angiogenesis, and inflammatory responses and immune surveillance (4). Matrix metalloproteinases (MMP) are the group of enzymes responsible for degradation of certain extracellular matrix proteins such as collagen, proteoglycan, elastin, laminin and fibronectin. Malignant diseases are accompanied with higher expression of matrix metalloproteinases and lower concentrations of the tissue inhibitors of matrix metalloproteinases (TIMP), also resulting in an increased proteolytic activity. The presence of matrix metalloproteinases was discovered on the surface of invasive tumor cells (5). Degradation of the basal membrane and extracellular matrix presents the key step in the process of intravasation and extravasation of tumor cells (6). MMP-9 belongs to the gelatinases group, synthesized by keratinocytes, monocytes, alveolar macrophages, polymorphonuclear neutrophil granulocytes, and in many cancer cells. Tumor invasion is a multi-phase process in which the cell motility is associated with controlled proteolysis and includes interaction between tumor cells and extracellular matrix. During the invasion process, malignant tumor cells are detached from the primary tumor, migrate through structural barriers such as the basal membrane and surrounding extracellular matrix rich in collagen. Degradation of the stromal extracellular matrix is also considered one of the key steps in the process of tumor angiogenesis (7). It has been proved that the activity of matrix metalloproteinases is necessary for increased motility of epithelial cells, as well as for the growth of metastatic deposits. Research has confirmed that MMP-2 and MMP-9 have an exceptionally significant role in metastasizing, due to their ability to degrade type IV The prognostic value of mmp-9 expression in lung adenocarcinoma","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"109-114"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Dobanovacki, N. Vuckovic, S. Marinković, J. Kolarovic, S. Bukarica
Tumors are rarely diagnosed in newborns. Natural history of such tumors, their type, and response to treatment differ from those seen in older children. The etiology is still unclear. In this paper, a retrospective study is presented of diagnostics and management of neonatal tumors from 2008 to 2012. Out of 518 neonatal admissions in that period, tumors were diagnosed in 15 patients (2.8%), in only 3 of them (20.0%) prenatally. The diagnosed tumors were teratomas (4), retroperitoneal (4), and liver tumors (7). Ten of them (66.6%) had a natural history of benign tumors. Complete surgical excision was the treatment of choice in 10 (66.6%) cases and there was no need for adjuvant chemotherapy.
{"title":"Neonatal oncology: Diagnostics and management","authors":"D. Dobanovacki, N. Vuckovic, S. Marinković, J. Kolarovic, S. Bukarica","doi":"10.2298/AOO1304125D","DOIUrl":"https://doi.org/10.2298/AOO1304125D","url":null,"abstract":"Tumors are rarely diagnosed in newborns. Natural history of such tumors, their type, and response to treatment differ from those seen in older children. The etiology is still unclear. In this paper, a retrospective study is presented of diagnostics and management of neonatal tumors from 2008 to 2012. Out of 518 neonatal admissions in that period, tumors were diagnosed in 15 patients (2.8%), in only 3 of them (20.0%) prenatally. The diagnosed tumors were teratomas (4), retroperitoneal (4), and liver tumors (7). Ten of them (66.6%) had a natural history of benign tumors. Complete surgical excision was the treatment of choice in 10 (66.6%) cases and there was no need for adjuvant chemotherapy.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"6 1","pages":"125-130"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ðuric, Mirjana Makevic-Ðuric, Dobrica Gajic, G. Damjanović
Cutaneous metastases of lung tumors are occurring in 1-12% of cases. High prevalence of lung cancer increases the likelihood of finding these changes in clinical practice. They are usually in the form of a firm, mobile and painless nodule on the head, neck and chest, and their appearance is a sign of advanced disease. Cutaneous metastases are rarely the first sign of malignancy. A 62-year-old patient presented to her doctor a fast-growing nodule on the forehead. Extirpation of the nodule and further diagnosis showed that it was a metastasis of small cell lung cancer localized in the right lung with extensive metastases to the contralateral lung, liver and spine. Cutaneous metastases may be the first sign of malignancy or the first sign of progression of already diagnosed malignancy. A diagnosis of metastatic disease should be considered in patients with risk factors or a known cancer. The presence of a skin metastasis in a patient with a lung cancer indicates poor prognosis.
{"title":"Cutaneous metastasis as the first sign of lung cancer","authors":"M. Ðuric, Mirjana Makevic-Ðuric, Dobrica Gajic, G. Damjanović","doi":"10.2298/AOO1301020D","DOIUrl":"https://doi.org/10.2298/AOO1301020D","url":null,"abstract":"Cutaneous metastases of lung tumors are occurring in 1-12% of cases. High prevalence of lung cancer increases the likelihood of finding these changes in clinical practice. They are usually in the form of a firm, mobile and painless nodule on the head, neck and chest, and their appearance is a sign of advanced disease. Cutaneous metastases are rarely the first sign of malignancy. A 62-year-old patient presented to her doctor a fast-growing nodule on the forehead. Extirpation of the nodule and further diagnosis showed that it was a metastasis of small cell lung cancer localized in the right lung with extensive metastases to the contralateral lung, liver and spine. Cutaneous metastases may be the first sign of malignancy or the first sign of progression of already diagnosed malignancy. A diagnosis of metastatic disease should be considered in patients with risk factors or a known cancer. The presence of a skin metastasis in a patient with a lung cancer indicates poor prognosis.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"20-22"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1301020D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Nersesyan, G. Parsadanyan, G. Zalinyan, N. Chobanyan
{"title":"The influence of indirect exposure to chlorine pesticides on nuclear anomalies in exfoliated buccal cells","authors":"A. Nersesyan, G. Parsadanyan, G. Zalinyan, N. Chobanyan","doi":"10.2298/AOO1304115N","DOIUrl":"https://doi.org/10.2298/AOO1304115N","url":null,"abstract":"","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"115-117"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
www.onk.ns.ac.rs/Archive Vol 21, No. 3-4, December 2013 INTRODUCTION The earliest research in the antineoplastic drug discovery was related to suppressing the synthesis and function of DNA. Today, a variety of other targets is under intensive investigation and they will provide oncologist with significant new approaches of therapy. Some of these approaches are inhibition of protease involved in metastasis, angiogenesis inhibitors, antisense technology, and G-quadruplexes. G-quadruplexes are generally formed in DNA and RNA sequences containing repeated G-G-G-G called as G-tetrad. G-quadruplexes formed from planar stacking of hoogsteen bonded G-tetrads (1, 2) folded from a single G-rich sequence by intraor inter-molecular association of 2 to 4 separate strands (3, 4). The core of G-quadruplexes are formed by the stacking of several G-tetrads and joined together by sugar phosphate backbone. The binding energy for this process arises from three main factors: hydrogen bonding between the guanines in a plane, π π interaction between the guanines in adjacent planes and charge – charge interaction between partially negative oxygen of guanines and cations that typically sit in the octahedral position between the stacks (5-7). The monovalent cations such as K+ and Na+ at a physiological temperature and pH stabilize G-quadruplex by coordinating the carbonyl group of guanine at the center of G-tetrad core (5, 8). It has been estimated that there are more than 376,000 potential quadruplex sequences found in number of important biological processes (9). Intramolecular G-quadruplexes formed by single-stranded DNA are currently under intensive research due to their potential formation in telomeres and promoter sequences (10, 11). The present review reports the G-quadruplexes formed in human telomeres and proto-oncogenes.
{"title":"Insights of potential G-quadruplex sequences in telomeres and proto-oncogenes","authors":"R. Bhadane, Rupali R. Bhadane, D. Meshram","doi":"10.2298/AOO1304118B","DOIUrl":"https://doi.org/10.2298/AOO1304118B","url":null,"abstract":"www.onk.ns.ac.rs/Archive Vol 21, No. 3-4, December 2013 INTRODUCTION The earliest research in the antineoplastic drug discovery was related to suppressing the synthesis and function of DNA. Today, a variety of other targets is under intensive investigation and they will provide oncologist with significant new approaches of therapy. Some of these approaches are inhibition of protease involved in metastasis, angiogenesis inhibitors, antisense technology, and G-quadruplexes. G-quadruplexes are generally formed in DNA and RNA sequences containing repeated G-G-G-G called as G-tetrad. G-quadruplexes formed from planar stacking of hoogsteen bonded G-tetrads (1, 2) folded from a single G-rich sequence by intraor inter-molecular association of 2 to 4 separate strands (3, 4). The core of G-quadruplexes are formed by the stacking of several G-tetrads and joined together by sugar phosphate backbone. The binding energy for this process arises from three main factors: hydrogen bonding between the guanines in a plane, π π interaction between the guanines in adjacent planes and charge – charge interaction between partially negative oxygen of guanines and cations that typically sit in the octahedral position between the stacks (5-7). The monovalent cations such as K+ and Na+ at a physiological temperature and pH stabilize G-quadruplex by coordinating the carbonyl group of guanine at the center of G-tetrad core (5, 8). It has been estimated that there are more than 376,000 potential quadruplex sequences found in number of important biological processes (9). Intramolecular G-quadruplexes formed by single-stranded DNA are currently under intensive research due to their potential formation in telomeres and promoter sequences (10, 11). The present review reports the G-quadruplexes formed in human telomeres and proto-oncogenes.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"118-124"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68402249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Lukić, Z. Radovanovic, T. Petrovic, M. Breberina, A. Golubović, Svetlana Škorić-Jokić
Background: Rectal cancer treatment has been dramatically improved during the last two decades in terms of a lower local recurrence rate and prolonged survival. This improvement was achieved mainly due to a better surgical technique (implementation of a total mesorectal excision-TME) and neoadjuvant chemo and radio therapy. A more radical approach to abdominoperineal excision, extralevator abdominoperineal excision technique in the prone Jack- knife position, may improve the oncological outcome. The aim of this study is to show our early experience by using extralevator abdominoperineal excision. Methods: Extralevator abdominoperineal excision has been used routinely at Oncology Institute of Vojvodina since 2011. In the last 23 months, we had 11 operations. Clinical and pathological data were obtained from operative proto- cols, histopathological data and patients' medical history. Results: An audit of results showed reduced rate of intra-operative perforations and circumferential resection margin involvement. Late postoperative complications have occurred in two patients, sexual dysfunction in one and pelvic pain in the other. The follow up period is too short (min 2 months, max 23 months, median 8 months) for analysis of local recurrence.
{"title":"Oncologic superiority of extralevator abdominoperineal excision for low rectal cancer","authors":"D. Lukić, Z. Radovanovic, T. Petrovic, M. Breberina, A. Golubović, Svetlana Škorić-Jokić","doi":"10.2298/AOO1301011L","DOIUrl":"https://doi.org/10.2298/AOO1301011L","url":null,"abstract":"Background: Rectal cancer treatment has been dramatically improved during the last two decades in terms of a lower local recurrence rate and prolonged survival. This improvement was achieved mainly due to a better surgical technique (implementation of a total mesorectal excision-TME) and neoadjuvant chemo and radio therapy. A more radical approach to abdominoperineal excision, extralevator abdominoperineal excision technique in the prone Jack- knife position, may improve the oncological outcome. The aim of this study is to show our early experience by using extralevator abdominoperineal excision. Methods: Extralevator abdominoperineal excision has been used routinely at Oncology Institute of Vojvodina since 2011. In the last 23 months, we had 11 operations. Clinical and pathological data were obtained from operative proto- cols, histopathological data and patients' medical history. Results: An audit of results showed reduced rate of intra-operative perforations and circumferential resection margin involvement. Late postoperative complications have occurred in two patients, sexual dysfunction in one and pelvic pain in the other. The follow up period is too short (min 2 months, max 23 months, median 8 months) for analysis of local recurrence.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"11-13"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1301011L","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
2 SUMMARY Iodine is necessary for all living organisms. Deficiency of iodine in the organism leads to various diseases (including mental) and increased rates of cancer. It is well known that one third of the world's population lived in iodine-deficient areas. At present time, the primary intervention for preventing iodine deficiency disorders worldwide is through the iodization of salt. The two most common types of fortificant used to iodize salt are potassium iodide and potassium iodate. Iodine-containing compounds are also widely used in clinical medicine as a highly effective topical antimi- crobial agent that has been used clinically in the treatment of wounds. Hence, the genetic toxicology of iodine and iodine-containing compounds is very essential topic. In this literature review are analyzed the data concerning genetic toxicology and the influence of these compounds on tumor rates in epidemiological and experimental studies.
{"title":"Toxicology of iodine: A mini review","authors":"A. Ilin, A. Nersesyan","doi":"10.2298/AOO1302065I","DOIUrl":"https://doi.org/10.2298/AOO1302065I","url":null,"abstract":"2 SUMMARY Iodine is necessary for all living organisms. Deficiency of iodine in the organism leads to various diseases (including mental) and increased rates of cancer. It is well known that one third of the world's population lived in iodine-deficient areas. At present time, the primary intervention for preventing iodine deficiency disorders worldwide is through the iodization of salt. The two most common types of fortificant used to iodize salt are potassium iodide and potassium iodate. Iodine-containing compounds are also widely used in clinical medicine as a highly effective topical antimi- crobial agent that has been used clinically in the treatment of wounds. Hence, the genetic toxicology of iodine and iodine-containing compounds is very essential topic. In this literature review are analyzed the data concerning genetic toxicology and the influence of these compounds on tumor rates in epidemiological and experimental studies.","PeriodicalId":35645,"journal":{"name":"Archive of Oncology","volume":"21 1","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2298/AOO1302065I","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68401978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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