Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-173-177
M. M. Yablokov, O. Fabrikantov, N. Yablokova
The article presents a literature review regarding the use of silicone oil tamponade (ST) in rhegmatogenous retinal detachment (RRD) treatment. Vitrectomy, which produces a stable anatomical result in most patients, is currently recognized as one of the main methods of treating RRD. In complicated retinal detachments, vitrectomy is followed by ST tamponade of the vitreous cavity (VC). Despite the many benefits of ST, it carries the risk of a number of complications arising at different times after surgery. The duration of ST presence in the vitreous cavity during RRD treatment may vary substantially. The review presents ST complications, including an unexpected and hard to explain vision deterioration after silicone oil removal, and the correlation between the complications and the duration of ST presence in the vitreous cavity.
{"title":"Silicone oil tamponade in surgical treatment of rhegmatogenous retinal detachment","authors":"M. M. Yablokov, O. Fabrikantov, N. Yablokova","doi":"10.21516/2072-0076-2022-15-4-173-177","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-173-177","url":null,"abstract":"The article presents a literature review regarding the use of silicone oil tamponade (ST) in rhegmatogenous retinal detachment (RRD) treatment. Vitrectomy, which produces a stable anatomical result in most patients, is currently recognized as one of the main methods of treating RRD. In complicated retinal detachments, vitrectomy is followed by ST tamponade of the vitreous cavity (VC). Despite the many benefits of ST, it carries the risk of a number of complications arising at different times after surgery. The duration of ST presence in the vitreous cavity during RRD treatment may vary substantially. The review presents ST complications, including an unexpected and hard to explain vision deterioration after silicone oil removal, and the correlation between the complications and the duration of ST presence in the vitreous cavity.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46158388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-49-57
V. Neroev, T. N. Kiseleva, E. K. Eliseeva, A. Baeva, K. V. Lugovkina
Purpose: to develop objective acoustic criteria of the condition of the optic nerve and its sheaths for an early diagnosis of intracranial hypertension (IH). Material and methods. The research involved 24 patients (average age 35.8 ± 8.5 years) with suspected IH. The control group consisted of 48 healthy subjects (average age 28.5 ± 9.5 years). Ultrasound examination of the retrobulbar part of the optic nerve (ON) included the measurement of the ON thickness with sheaths (ONSD) and without sheaths (OND) and the calculation of the ratio K = ONSD/ OND. Echodensitometry was used to evaluate the echographic density of the parenchyma and the sheaths of the optic nerve. All patients were tested with magnetic resonance imaging (MRI) to analyse brain images. Results. The biometrical parameters of ON in healthy subjects were as follows: ONS 2.64 ± 0.21 mm and ONSD — 4.60 ± 0.34 mm. In patients with suspected IH the average parameters of the ON diameter were as follows: ONS — 2.57 ± 0.25 mm and ONSD — 5.81 ± 0.42 mm. A comparative assessment of the ON thickness with and without sheaths showed that in the control group the values of ONS did not exceed 3.5 mm and ONSD did not exceed 5.0 mm. In patients with IH, the values of ONSD were significantly higher than those in the control group (p < 0.05). The ratio coefficient (K)=ONSD/ONS in the group of healthy subjects ranged from 1.53 to 2.0 and averaged 1.75 ± 0.14. In patients with IH the values of K exceeded 2.0 (2,40 ± 0.18). The analysis of acoustic density data showed a significant variability in the parameters of the ON sheaths echodensitometry in IH patients as compared to the norm. Conclusion. The echography of the ON makes it possible to determine the acoustic and biometric parameters of the ON with high accuracy, to assess its structure and relationship with the surrounding tissues. The ratio coefficient (K) of ONSD/ONS makes it possible to determine IH in the early stages of the disease, even in the absence of objective clinical criteria.
{"title":"Echographic criteria for the assessment of the optic nerve condition in intracranial hypertension","authors":"V. Neroev, T. N. Kiseleva, E. K. Eliseeva, A. Baeva, K. V. Lugovkina","doi":"10.21516/2072-0076-2022-15-4-49-57","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-49-57","url":null,"abstract":"Purpose: to develop objective acoustic criteria of the condition of the optic nerve and its sheaths for an early diagnosis of intracranial hypertension (IH). Material and methods. The research involved 24 patients (average age 35.8 ± 8.5 years) with suspected IH. The control group consisted of 48 healthy subjects (average age 28.5 ± 9.5 years). Ultrasound examination of the retrobulbar part of the optic nerve (ON) included the measurement of the ON thickness with sheaths (ONSD) and without sheaths (OND) and the calculation of the ratio K = ONSD/ OND. Echodensitometry was used to evaluate the echographic density of the parenchyma and the sheaths of the optic nerve. All patients were tested with magnetic resonance imaging (MRI) to analyse brain images. Results. The biometrical parameters of ON in healthy subjects were as follows: ONS 2.64 ± 0.21 mm and ONSD — 4.60 ± 0.34 mm. In patients with suspected IH the average parameters of the ON diameter were as follows: ONS — 2.57 ± 0.25 mm and ONSD — 5.81 ± 0.42 mm. A comparative assessment of the ON thickness with and without sheaths showed that in the control group the values of ONS did not exceed 3.5 mm and ONSD did not exceed 5.0 mm. In patients with IH, the values of ONSD were significantly higher than those in the control group (p < 0.05). The ratio coefficient (K)=ONSD/ONS in the group of healthy subjects ranged from 1.53 to 2.0 and averaged 1.75 ± 0.14. In patients with IH the values of K exceeded 2.0 (2,40 ± 0.18). The analysis of acoustic density data showed a significant variability in the parameters of the ON sheaths echodensitometry in IH patients as compared to the norm. Conclusion. The echography of the ON makes it possible to determine the acoustic and biometric parameters of the ON with high accuracy, to assess its structure and relationship with the surrounding tissues. The ratio coefficient (K) of ONSD/ONS makes it possible to determine IH in the early stages of the disease, even in the absence of objective clinical criteria.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43955423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-7-17
E. V. Bobykin, R. V. Buslaev, V. Krokhalev, O. Morozova, N. S. Beresneva
Purpose: to study long-term results of anti-VEGF therapy for macular diseases of patients followed up for 60 months in real clinical practice. Materials and methods. The research group included 57 patients (43 women, 14 men; median age 62 years) who received antiVEGF therapy (ranibizumab, aflibercept) and remained under regular observation for 60 months. Of these, 24 patients had “wet” agerelated macular degeneration (wAMD), 20 had myopic choroidal neovascularization (mCNV), 10 had macular edema due to retinal vein occlusions (MERVO), and 3 patients had diabetic macular edema (DME). Statistical analysis of demographic indicators and treatment results was carried out using STATISTICA 13.3 software: conditions of normality for variables, nonparametric and parametric criteria were determined, and rank analysis of variance was carried out. The characteristics of the study group are given in the first part of this article [ROJ, 2022; 15 (3): 11–17]. Results. Over the research period, the best corrected visual acuity (BCVA) increased from 0.29 0.35 0.42 to 0.47 0.54 0.61 (p < 0.00001); 91.2 % of patients maintained the indicator or improved it with regard to the baseline. The proportion of subjects with BCVA ≥ 0.5 ranged from 61.4 to 73.7 % during the research period. The average number of intravitreal injections (IVI) received by the patients was 8.93 10.84 12.75. We revealed a tendency towards a gradual decrease in the intensity of treatment and confirmed it (p < 0.00001). The proportion of patients who received 4 IVI or more over 12 months of treatment decreased from 57.9 % in the first year to 12.3 % in the fifth year, and the proportion of cases where anti-VEGF therapy did not need to be resumed before the end of the year of treatment increased from 28.1 % (in the second year of research) to 49.1 % (in the fifth year). The need for IVI anti-VEGF drugs in wAMD and DME was significantly greater than in MERVO and mCNV. Conclusion. The results confirm high efficiency of anti-VEGF therapy. To solve the issue of ill-timed or insufficient treatment, it is necessary to start the therapy as early as possible, use the most effective (proactive) regimens, apply individualized approach to the treatment, take organizational measures aimed at facilitation of access to specialized care, and, generally, to change the attitude of the professional community.
{"title":"Long-term results (60 months) of anti-VEGF therapy of macular diseases in real clinical practice. Part 2.","authors":"E. V. Bobykin, R. V. Buslaev, V. Krokhalev, O. Morozova, N. S. Beresneva","doi":"10.21516/2072-0076-2022-15-4-7-17","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-7-17","url":null,"abstract":"Purpose: to study long-term results of anti-VEGF therapy for macular diseases of patients followed up for 60 months in real clinical practice. Materials and methods. The research group included 57 patients (43 women, 14 men; median age 62 years) who received antiVEGF therapy (ranibizumab, aflibercept) and remained under regular observation for 60 months. Of these, 24 patients had “wet” agerelated macular degeneration (wAMD), 20 had myopic choroidal neovascularization (mCNV), 10 had macular edema due to retinal vein occlusions (MERVO), and 3 patients had diabetic macular edema (DME). Statistical analysis of demographic indicators and treatment results was carried out using STATISTICA 13.3 software: conditions of normality for variables, nonparametric and parametric criteria were determined, and rank analysis of variance was carried out. The characteristics of the study group are given in the first part of this article [ROJ, 2022; 15 (3): 11–17]. Results. Over the research period, the best corrected visual acuity (BCVA) increased from 0.29 0.35 0.42 to 0.47 0.54 0.61 (p < 0.00001); 91.2 % of patients maintained the indicator or improved it with regard to the baseline. The proportion of subjects with BCVA ≥ 0.5 ranged from 61.4 to 73.7 % during the research period. The average number of intravitreal injections (IVI) received by the patients was 8.93 10.84 12.75. We revealed a tendency towards a gradual decrease in the intensity of treatment and confirmed it (p < 0.00001). The proportion of patients who received 4 IVI or more over 12 months of treatment decreased from 57.9 % in the first year to 12.3 % in the fifth year, and the proportion of cases where anti-VEGF therapy did not need to be resumed before the end of the year of treatment increased from 28.1 % (in the second year of research) to 49.1 % (in the fifth year). The need for IVI anti-VEGF drugs in wAMD and DME was significantly greater than in MERVO and mCNV. Conclusion. The results confirm high efficiency of anti-VEGF therapy. To solve the issue of ill-timed or insufficient treatment, it is necessary to start the therapy as early as possible, use the most effective (proactive) regimens, apply individualized approach to the treatment, take organizational measures aimed at facilitation of access to specialized care, and, generally, to change the attitude of the professional community.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49010843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-30-37
M. Kovalevskaya, V. B. Antonyan, E. V. Muntianova, M. Zueva
Purpose: identification of early risk factors — predictors of POAG development in students with myopic refraction based on questionnaire and functional test data and the effects of fractal photostimulation (FS). Material and methods. The study involved two clinical groups: the main group of 24 students (48 eyes) with mild to moderate myopia, averagely aged 21.3 ± 0.7 years, and the comparison group (according to FS effects) of 29 patients (58 eyes) with an established diagnosis of stage I–III POAG, averagely aged 58 ± 18 years, and a control group consisting of 66 people (132 eyes, mean age 21.2 ± 1.3 years). The case history of patients and typical complaints were found in questionnaire data. For the two clinical groups, the impact of 10 low-intensity FS sessions was evaluated. Results. A set of features viewed as risk factors for POAG development was determined using the data of the questionaries filled in by the main and comparison groups. The changes in mean IOP values measured before and after an FS course were found to be greater in POAG patients than in myopic students. FS was shown to contribute to IOP stabilization in patients with pre-existing morphological and functional glaucoma changes and the occurrence of accompanying pathologies such as vasospasm, blood pressure fluctuations, and migraine-like pain. After a course of FS, overall photosensitivity increased significantly as compared with the baseline in students with mild and moderate myopia (p < 0.05). Also, a positive effect of an FS course on MD indices in patients with stages IIa and IIIa POAG was confirmed. Conclusion. The research results confirm the need to identify clinical and functional predictors of POAG with a progressive glaucomatous process in students with myopic refraction.
{"title":"Risk factors as glaucoma predictors in myopic students","authors":"M. Kovalevskaya, V. B. Antonyan, E. V. Muntianova, M. Zueva","doi":"10.21516/2072-0076-2022-15-4-30-37","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-30-37","url":null,"abstract":"Purpose: identification of early risk factors — predictors of POAG development in students with myopic refraction based on questionnaire and functional test data and the effects of fractal photostimulation (FS). Material and methods. The study involved two clinical groups: the main group of 24 students (48 eyes) with mild to moderate myopia, averagely aged 21.3 ± 0.7 years, and the comparison group (according to FS effects) of 29 patients (58 eyes) with an established diagnosis of stage I–III POAG, averagely aged 58 ± 18 years, and a control group consisting of 66 people (132 eyes, mean age 21.2 ± 1.3 years). The case history of patients and typical complaints were found in questionnaire data. For the two clinical groups, the impact of 10 low-intensity FS sessions was evaluated. Results. A set of features viewed as risk factors for POAG development was determined using the data of the questionaries filled in by the main and comparison groups. The changes in mean IOP values measured before and after an FS course were found to be greater in POAG patients than in myopic students. FS was shown to contribute to IOP stabilization in patients with pre-existing morphological and functional glaucoma changes and the occurrence of accompanying pathologies such as vasospasm, blood pressure fluctuations, and migraine-like pain. After a course of FS, overall photosensitivity increased significantly as compared with the baseline in students with mild and moderate myopia (p < 0.05). Also, a positive effect of an FS course on MD indices in patients with stages IIa and IIIa POAG was confirmed. Conclusion. The research results confirm the need to identify clinical and functional predictors of POAG with a progressive glaucomatous process in students with myopic refraction.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49464223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-23-29
L. Katargina, T. B. Kruglova, A. S. Mamykina, N. S. Egiyan, N. N. Arestova
After the extraction of congenital cataract in infancy, postoperative refraction changes differently in patients with bilateral and unilateral pseudophakia. Purpose: to compare myopia development in children with bilateral and unilateral pseudophakia. Material and methods. We examined 33 children (63 eyes) with bilateral and 21 children with unilateral pseudophakia for long-term results of congenital cataract extraction performed in their infancy, The evaluated parameters included the incidence and degree of myopia, refraction, general postsurgical astigmatism, and axial length of the eye. Refraction was measured by Nidek ARK-530A (Japan). The axial length was measured by ultrasound B-scan (Voluson E8, GE) or by optical biometry (AL-Scan, Nidek). Results. In bilateral pseudophakia, high myopia was detected if astigmatism was more than 3.25 D or oblique. In the latter case, the eyeball showed a greater growth as compared to with-the-rule astigmatism (4.67 mm and 3.26 mm, respectively; p < 0.05). With incomplete correction of astigmatism in the case of bilateral pseudophakia, myopia progressed to a high degree in nearly half of the cases (48.1 %), and a greater growth of the eye was detected compared with complete correction (4.45 mm and 3.42 mm respectively; p > 0.05). The type and degree of astigmatism did not affect the development and progression of myopia in unilateral pseudophakia. Conclusion. The effect of undercorrected astigmatic defocus on the development and progression of myopia in bilateral pseudophakia is apparently associated with a equivalent visual load on both eyes, while this load is significantly reduced in unilateral pseudophakia so that it fails to affect the development of myopia in such cases.
{"title":"A comparative analysis of myopia development in children with bilateral and unilateral pseudophakia","authors":"L. Katargina, T. B. Kruglova, A. S. Mamykina, N. S. Egiyan, N. N. Arestova","doi":"10.21516/2072-0076-2022-15-4-23-29","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-23-29","url":null,"abstract":"After the extraction of congenital cataract in infancy, postoperative refraction changes differently in patients with bilateral and unilateral pseudophakia. Purpose: to compare myopia development in children with bilateral and unilateral pseudophakia. Material and methods. We examined 33 children (63 eyes) with bilateral and 21 children with unilateral pseudophakia for long-term results of congenital cataract extraction performed in their infancy, The evaluated parameters included the incidence and degree of myopia, refraction, general postsurgical astigmatism, and axial length of the eye. Refraction was measured by Nidek ARK-530A (Japan). The axial length was measured by ultrasound B-scan (Voluson E8, GE) or by optical biometry (AL-Scan, Nidek). Results. In bilateral pseudophakia, high myopia was detected if astigmatism was more than 3.25 D or oblique. In the latter case, the eyeball showed a greater growth as compared to with-the-rule astigmatism (4.67 mm and 3.26 mm, respectively; p < 0.05). With incomplete correction of astigmatism in the case of bilateral pseudophakia, myopia progressed to a high degree in nearly half of the cases (48.1 %), and a greater growth of the eye was detected compared with complete correction (4.45 mm and 3.42 mm respectively; p > 0.05). The type and degree of astigmatism did not affect the development and progression of myopia in unilateral pseudophakia. Conclusion. The effect of undercorrected astigmatic defocus on the development and progression of myopia in bilateral pseudophakia is apparently associated with a equivalent visual load on both eyes, while this load is significantly reduced in unilateral pseudophakia so that it fails to affect the development of myopia in such cases.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43587410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-156-165
N. Kurysheva, O. A. Pererva, A. D. Nikitina
In COVID-19, eye damage may develop at any stage of the disease. Viral ribonucleic acid has been found in ocular tissues, but the role of the eye as a route of infection is yet to be substantiated. Ophthalmic manifestations may be a typical feature of COVID-19 infection or they may develop several weeks after recovery. Ophthalmologists should be aware of possible relationships of an ophthalmic pathology with SARS-CoV-2 in order to obtain targeted case history, detect the specific signs, prescribe the necessary tests and thereby reduce the spread of the infection. These relationships are also important for early diagnosis and treatment of complications that threaten the patients’ life and vision. The first part of the review focuses on the possible involvement of the eye in SARS-CoV-2 infection and the spread of infection. Clinical manifestations of the anterior segment damage are considered.
{"title":"Eye damage in COVID-19. Part 1: Involvement of the eye in SARS-CoV-2 virus transmission and anterior segment complications","authors":"N. Kurysheva, O. A. Pererva, A. D. Nikitina","doi":"10.21516/2072-0076-2022-15-4-156-165","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-156-165","url":null,"abstract":"In COVID-19, eye damage may develop at any stage of the disease. Viral ribonucleic acid has been found in ocular tissues, but the role of the eye as a route of infection is yet to be substantiated. Ophthalmic manifestations may be a typical feature of COVID-19 infection or they may develop several weeks after recovery. Ophthalmologists should be aware of possible relationships of an ophthalmic pathology with SARS-CoV-2 in order to obtain targeted case history, detect the specific signs, prescribe the necessary tests and thereby reduce the spread of the infection. These relationships are also important for early diagnosis and treatment of complications that threaten the patients’ life and vision. The first part of the review focuses on the possible involvement of the eye in SARS-CoV-2 infection and the spread of infection. Clinical manifestations of the anterior segment damage are considered.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45467667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-77-83
S. Saakyan, N. V. Sklyarova, A. Tsygankov, M. G. Zhiltsova, V. R. Alikhanova, R. Tatskov
Purpose. To analyze the results of treatment and active monitoring the children with orbital rhabdomyosarcoma (RMS) with an emphasis on vital prognosis. Material and methods. We examined 32 children with RMS (18 boys, 14 girls) aged 2 months to 12 years, whose case history ranged from 1 week to 16 weeks (median, 5 weeks). The median follow-up was 60 months. The tumor was localized in the upper (n = 13), upper internal (n = 9), lower (n = 4), internal (n = 3), and external (n = 3) quadrants. The patients underwent primary surgical treatment: orbitotomy using transcutaneous (n = 26), transconjunctival (n = 2) and subperiosteal access (n = 4) followed by cytological, histological and immunohistochemical tissue verification in all cases. Results. The highest number of RMS cases was noted in in the 2- to 7-year-old group (66 % of patients). All patients were treated in in-patient settings. Complete macroscopic removal of tumor was performed in 17 cases, partial removal in 9 cases, and biopsy sampling in 6 cases. The embryonic type of RMS accounted for 87 % (n = 28), and the alveolar type, for 13 % (n = 6). In the postoperative period all children received combined therapy (systemic polychemotherapy and distant radiation therapy) in in-patient facilities of special oncological and radiological clinics. The survival rate of the whole group was 100%. In the long-term follow-up period (after 3 to 5 years), reconstructive surgeries were performed to correct ptosis and strabismus, and/or spectacle or prismatic correction of complex or mixed astigmatism. In cases of “dry” eye syndrome, conservative local therapy was offered. After orbital exenteration, ectoprosthesis procedures was applied. Conclusion. The analysis of our observations of 32 children with orbital rhabdomyosarcoma showed a 100 % survival rate, which testifies to the importance of timely diagnosis and combined treatment of the tumor.
{"title":"Orbital rhabdomyosarcoma in children","authors":"S. Saakyan, N. V. Sklyarova, A. Tsygankov, M. G. Zhiltsova, V. R. Alikhanova, R. Tatskov","doi":"10.21516/2072-0076-2022-15-4-77-83","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-77-83","url":null,"abstract":"Purpose. To analyze the results of treatment and active monitoring the children with orbital rhabdomyosarcoma (RMS) with an emphasis on vital prognosis. Material and methods. We examined 32 children with RMS (18 boys, 14 girls) aged 2 months to 12 years, whose case history ranged from 1 week to 16 weeks (median, 5 weeks). The median follow-up was 60 months. The tumor was localized in the upper (n = 13), upper internal (n = 9), lower (n = 4), internal (n = 3), and external (n = 3) quadrants. The patients underwent primary surgical treatment: orbitotomy using transcutaneous (n = 26), transconjunctival (n = 2) and subperiosteal access (n = 4) followed by cytological, histological and immunohistochemical tissue verification in all cases. Results. The highest number of RMS cases was noted in in the 2- to 7-year-old group (66 % of patients). All patients were treated in in-patient settings. Complete macroscopic removal of tumor was performed in 17 cases, partial removal in 9 cases, and biopsy sampling in 6 cases. The embryonic type of RMS accounted for 87 % (n = 28), and the alveolar type, for 13 % (n = 6). In the postoperative period all children received combined therapy (systemic polychemotherapy and distant radiation therapy) in in-patient facilities of special oncological and radiological clinics. The survival rate of the whole group was 100%. In the long-term follow-up period (after 3 to 5 years), reconstructive surgeries were performed to correct ptosis and strabismus, and/or spectacle or prismatic correction of complex or mixed astigmatism. In cases of “dry” eye syndrome, conservative local therapy was offered. After orbital exenteration, ectoprosthesis procedures was applied. Conclusion. The analysis of our observations of 32 children with orbital rhabdomyosarcoma showed a 100 % survival rate, which testifies to the importance of timely diagnosis and combined treatment of the tumor.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46928962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-107-114
Y. A. Huseva, O. Zharikova, A. V. Vasilevskaya
Purpose. To investigate the cell composition of the tear in healthy women and endometriosis patients in order to find the potential diagnostic criteria of endometriosis. Material and methods. Tear samples obtained from the lower fornix of the conjunctiva using a glass capillary tube were microscopically examined in 100 females aged 18 to 48: 60 healthy women, who made up the control group, and 40 patients with endometriosis. Results. The share of women with endometriosis who were found to have erythrocytes was 32.5 %, which was significantly higher as compared with the control group, where it was 25.0%. 69.2 % of women with endometriosis showed haemolacria in the follicular phase of the menstrual cycle, which significantly exceeded the percentage of women with erythrocytes in the tear (30.8 %) who had them in the luteal phase. Epitheliocytes were found in the tear of 97.5 % of patients with endometriosis, versus 75.0 % of healthy women. In all 100 % of such patients, these cells were found in the follicular phase of the menstrual cycle, compared with 74.3 % of healthy women who showed these cells in the same phase of the cycle. The share of women with endometriosis showing the ++ quantity of epitheliocytes in the tear was 56.4 %, which was significantly higher than the 20 % of the control group subject with the same level of epitheliocytes. It is to be noted that group accumulations of epitheliocytes were found in 15 % of endometriotic patients, which was significantly higher than in healthy women, of whom only 8.3 % had such accumulations. 90 % of endometriosis group cases revealed glandular cuboidal epithelial cells in the tear, which morphologically resembling endometrial cells. Conclusion. The revealed properties of the cytological composition of the tear of patients with endometriosis reflected particular links in its etiopathogenesis, which suggests that the study of tear parameters can help predict the incidence of the "endometrioid disease" and develop pathogenetically oriented treatment methods.
{"title":"The prognostic value of the cytological composition of the tear in the diagnosis of endometriosis","authors":"Y. A. Huseva, O. Zharikova, A. V. Vasilevskaya","doi":"10.21516/2072-0076-2022-15-4-107-114","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-107-114","url":null,"abstract":"Purpose. To investigate the cell composition of the tear in healthy women and endometriosis patients in order to find the potential diagnostic criteria of endometriosis. Material and methods. Tear samples obtained from the lower fornix of the conjunctiva using a glass capillary tube were microscopically examined in 100 females aged 18 to 48: 60 healthy women, who made up the control group, and 40 patients with endometriosis. Results. The share of women with endometriosis who were found to have erythrocytes was 32.5 %, which was significantly higher as compared with the control group, where it was 25.0%. 69.2 % of women with endometriosis showed haemolacria in the follicular phase of the menstrual cycle, which significantly exceeded the percentage of women with erythrocytes in the tear (30.8 %) who had them in the luteal phase. Epitheliocytes were found in the tear of 97.5 % of patients with endometriosis, versus 75.0 % of healthy women. In all 100 % of such patients, these cells were found in the follicular phase of the menstrual cycle, compared with 74.3 % of healthy women who showed these cells in the same phase of the cycle. The share of women with endometriosis showing the ++ quantity of epitheliocytes in the tear was 56.4 %, which was significantly higher than the 20 % of the control group subject with the same level of epitheliocytes. It is to be noted that group accumulations of epitheliocytes were found in 15 % of endometriotic patients, which was significantly higher than in healthy women, of whom only 8.3 % had such accumulations. 90 % of endometriosis group cases revealed glandular cuboidal epithelial cells in the tear, which morphologically resembling endometrial cells. Conclusion. The revealed properties of the cytological composition of the tear of patients with endometriosis reflected particular links in its etiopathogenesis, which suggests that the study of tear parameters can help predict the incidence of the \"endometrioid disease\" and develop pathogenetically oriented treatment methods.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46378396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-150-155
E. Gromakina, V. G. Mozes, K. M. Saidzhamolov, N. V. Tunina, I. M. Tsenter
The article provides an overview of endophthalmitis cases in children with open eye injury — prevalence, causes and treatment results in Great Britain, USA, China, India, Vietnam, Saudi Arabia, and other countries with different healthcare facilities, lifestyle and traditions.
{"title":"Endophthalmitis in children with open eye injury: epidemiology, risk factors, treatment","authors":"E. Gromakina, V. G. Mozes, K. M. Saidzhamolov, N. V. Tunina, I. M. Tsenter","doi":"10.21516/2072-0076-2022-15-4-150-155","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-150-155","url":null,"abstract":"The article provides an overview of endophthalmitis cases in children with open eye injury — prevalence, causes and treatment results in Great Britain, USA, China, India, Vietnam, Saudi Arabia, and other countries with different healthcare facilities, lifestyle and traditions.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46743465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21516/2072-0076-2022-15-4-115-120
E. Chentsova, N. Borovkova, P. Makarov, D. A. Bozhenko, I. N. Ponomarev, M. V. Storozheva, M. Makarov
Purpose: To study the biological effect of a combination of platelet lysate and amniotic membrane, preserved by various techniques, on human buccal epithelium culture. Materials and methods. Human amnion transplants were preserved using 3 methods: silicate drying, lyophilization, cryopreservation. The blood of healthy volunteers was used as a source of platelets. Platelet-rich plasma (PRP) with a platelet content over 1000 thousand/mcl and more was isolated from the donors blood, frozen at -80 °С and defrosted at 0–4 °С to prepare platelet lysate. Growth-stimulating effect of the amnion transplants was studied in different groups: control group 1 — without amnion and without PRP lysate; control group 2 — PRP lysate without amnion; experimental group 1 — amnion without PRP lysate; experimental group 2 — amnion samples combined with PRP lysate. The study was carried out on the example of human buccal epithelium culture of 3–5 passages. The dynamics of cell growth was evaluated after 1, 2 and 3 days from the moment of seeding. The number of cells and their viability were evaluated using original methods based on vital cell staining and their examination in a fluorescent microscope. Results. All samples of preserved amnions were non-toxic and did not damage the structural and functional characteristics of the buccal epithelium. On the other hand, the use of amnion without PRP lysate did not have a growth-stimulating effect on cells. Among the amnion samples combined with PRP lysate, the combination of lyophilized amnion and PRP lysate was the most effective during the entire study period. Conclusions. Silicate drying, lyophilization and cryopreservation of the amniotic membrane makes it possible to obtain biocompatible and non-toxic transplants, based on human amnion. Lyophilized amnions are the most optimal for saturating PRP lysate. The combination of lyophilized amnion and PRP lysate stimulates cell growth in vitro without violating their structural integrity.
{"title":"The biological effect of a combination of platelet lysate and amniotic membrane in buccal epithelium culture","authors":"E. Chentsova, N. Borovkova, P. Makarov, D. A. Bozhenko, I. N. Ponomarev, M. V. Storozheva, M. Makarov","doi":"10.21516/2072-0076-2022-15-4-115-120","DOIUrl":"https://doi.org/10.21516/2072-0076-2022-15-4-115-120","url":null,"abstract":"Purpose: To study the biological effect of a combination of platelet lysate and amniotic membrane, preserved by various techniques, on human buccal epithelium culture. Materials and methods. Human amnion transplants were preserved using 3 methods: silicate drying, lyophilization, cryopreservation. The blood of healthy volunteers was used as a source of platelets. Platelet-rich plasma (PRP) with a platelet content over 1000 thousand/mcl and more was isolated from the donors blood, frozen at -80 °С and defrosted at 0–4 °С to prepare platelet lysate. Growth-stimulating effect of the amnion transplants was studied in different groups: control group 1 — without amnion and without PRP lysate; control group 2 — PRP lysate without amnion; experimental group 1 — amnion without PRP lysate; experimental group 2 — amnion samples combined with PRP lysate. The study was carried out on the example of human buccal epithelium culture of 3–5 passages. The dynamics of cell growth was evaluated after 1, 2 and 3 days from the moment of seeding. The number of cells and their viability were evaluated using original methods based on vital cell staining and their examination in a fluorescent microscope. Results. All samples of preserved amnions were non-toxic and did not damage the structural and functional characteristics of the buccal epithelium. On the other hand, the use of amnion without PRP lysate did not have a growth-stimulating effect on cells. Among the amnion samples combined with PRP lysate, the combination of lyophilized amnion and PRP lysate was the most effective during the entire study period. Conclusions. Silicate drying, lyophilization and cryopreservation of the amniotic membrane makes it possible to obtain biocompatible and non-toxic transplants, based on human amnion. Lyophilized amnions are the most optimal for saturating PRP lysate. The combination of lyophilized amnion and PRP lysate stimulates cell growth in vitro without violating their structural integrity.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45797209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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