Pub Date : 2023-07-01DOI: 10.21516/2072-0076-2023-16-2-124-129
A. Fursova, A. S. Derbeneva, I. Amir, O. Kozhevnikova, D. V. Telegina, V. Devyatkin
Purpose: to analyze intraocular fluid (IOF) cytokine concentrations in patients with diabetic macular edema (DME) after intravitreal therapy with angiogenesis inhibitors or corticosteroids (CS).Materials and methods. 44 patients (45 eyes) were divided in 2 groups depending on the therapy: group 1 (n = 19) received an angiogenesis inhibitor (aflibercept) while group2 (n = 26) received CS (dexamethasone implant). They were tested for IOF cytokine levels by Milliplex® Map Human Cytokine/Chemokine Panel at treatment start and 3 months after either 3 monthly injections of aflibercept or a single dexamethasone implant injection.Results. The concentrations of ten cytokines (IL-8/CXCL8, IP-10/CXCL10, MCP-1/CCL2, PDGF-AA, GROα/CXCL1, VEGF-A, MIP-1β/CCL4, IL-15, IL-7, IL-6) were found to fall significantly in both groups of therapy. IL-6 and IL-5 levels showed the most significant drop as compared to other cytokines, with a more pronounced decrease in the aflibercept treatment group. In both groups, VEGF-A concentration showed a significant drop, and the share of the eyes that responded to the treatment was 94.7 % in the aflibercept therapy group and 96.2 % in in the dexamethasone implant group.Conclusion. The IOF concentration assessment of a number of pro-inflammatory cytokines/chemokines shows that both the anti-VEGF agent — aflibercept and CS — dexamethasone implant contribute to a decrease of inflammation which is observed 3 months after the start of treatment.
{"title":"Aqeuous humor cytokines concentration changes in patients with diabetic macular edema after intravitreal pharmacotherapy","authors":"A. Fursova, A. S. Derbeneva, I. Amir, O. Kozhevnikova, D. V. Telegina, V. Devyatkin","doi":"10.21516/2072-0076-2023-16-2-124-129","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-124-129","url":null,"abstract":"Purpose: to analyze intraocular fluid (IOF) cytokine concentrations in patients with diabetic macular edema (DME) after intravitreal therapy with angiogenesis inhibitors or corticosteroids (CS).Materials and methods. 44 patients (45 eyes) were divided in 2 groups depending on the therapy: group 1 (n = 19) received an angiogenesis inhibitor (aflibercept) while group2 (n = 26) received CS (dexamethasone implant). They were tested for IOF cytokine levels by Milliplex® Map Human Cytokine/Chemokine Panel at treatment start and 3 months after either 3 monthly injections of aflibercept or a single dexamethasone implant injection.Results. The concentrations of ten cytokines (IL-8/CXCL8, IP-10/CXCL10, MCP-1/CCL2, PDGF-AA, GROα/CXCL1, VEGF-A, MIP-1β/CCL4, IL-15, IL-7, IL-6) were found to fall significantly in both groups of therapy. IL-6 and IL-5 levels showed the most significant drop as compared to other cytokines, with a more pronounced decrease in the aflibercept treatment group. In both groups, VEGF-A concentration showed a significant drop, and the share of the eyes that responded to the treatment was 94.7 % in the aflibercept therapy group and 96.2 % in in the dexamethasone implant group.Conclusion. The IOF concentration assessment of a number of pro-inflammatory cytokines/chemokines shows that both the anti-VEGF agent — aflibercept and CS — dexamethasone implant contribute to a decrease of inflammation which is observed 3 months after the start of treatment.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46452700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21516/2072-0076-2023-16-2-67-73
S. Petrov, O. M. Kalinina, L. V. Yakubova, S. M. Kosakyan, L. V. Vasilenkova, O. M. Filippova, A. Zhuravleva, O. I. Markelova
Purpose: a comparative study of the efficacy and safety of the combination drug Brinzopt Plus and the original drug Azarga used as adjunctive therapy in patients with primary open-angle glaucoma (POAG) previously treated with latanoprost.Material and methods. 30 patients (42 eyes) with advanced and far advanced POAG were randomly divided into 2 groups of equal size. The patients of the main group (21 eyes) received Brinzopt Plus, those of the control group had the original drug Azarga, one instillation 2 times a day. The target points were intraocular pressure (IOP), visual acuity, perimetric indices (MD, PSD), mean retinal nerve fiber layer thickness, minimal neuroretinal rim width, retinal nerve fiber layer thickness in the macula, ganglion cell layer thickness in the macula, inner plexiform layer thickness, as well as the number of adverse events. The observation period was 12 weeks. IOP was measured at 4 and 12 weeks.Results. After 2 weeks, both groups showed a statistically significant decrease in IOP, which remained stable after 4 and 12 weeks. The average decrease in IOP in Brinzopt Plus recipients was 25% and revealed no statistically significant differences with the original drug at any control point. A positive dynamic of visual acuity, static perimetry and optical coherence tomography values, which showed no significant intergroup differences, was recorded. Among the adverse events, manifestations of mild local discomfort were recorded in 4 out of 15 patients of the main group and in 3 out of 15 patients of the control group. No serious or systemic adverse events were noted.Conclusion. Brinzopt Plus has an efficacy comparable to the original drug and a favorable safety profile.
{"title":"Adjunctive antihypertensive therapy of primary glaucoma with a fixed combination drug of 1% brinzolamide and 0.5% timolol: efficacy and safety","authors":"S. Petrov, O. M. Kalinina, L. V. Yakubova, S. M. Kosakyan, L. V. Vasilenkova, O. M. Filippova, A. Zhuravleva, O. I. Markelova","doi":"10.21516/2072-0076-2023-16-2-67-73","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-67-73","url":null,"abstract":"Purpose: a comparative study of the efficacy and safety of the combination drug Brinzopt Plus and the original drug Azarga used as adjunctive therapy in patients with primary open-angle glaucoma (POAG) previously treated with latanoprost.Material and methods. 30 patients (42 eyes) with advanced and far advanced POAG were randomly divided into 2 groups of equal size. The patients of the main group (21 eyes) received Brinzopt Plus, those of the control group had the original drug Azarga, one instillation 2 times a day. The target points were intraocular pressure (IOP), visual acuity, perimetric indices (MD, PSD), mean retinal nerve fiber layer thickness, minimal neuroretinal rim width, retinal nerve fiber layer thickness in the macula, ganglion cell layer thickness in the macula, inner plexiform layer thickness, as well as the number of adverse events. The observation period was 12 weeks. IOP was measured at 4 and 12 weeks.Results. After 2 weeks, both groups showed a statistically significant decrease in IOP, which remained stable after 4 and 12 weeks. The average decrease in IOP in Brinzopt Plus recipients was 25% and revealed no statistically significant differences with the original drug at any control point. A positive dynamic of visual acuity, static perimetry and optical coherence tomography values, which showed no significant intergroup differences, was recorded. Among the adverse events, manifestations of mild local discomfort were recorded in 4 out of 15 patients of the main group and in 3 out of 15 patients of the control group. No serious or systemic adverse events were noted.Conclusion. Brinzopt Plus has an efficacy comparable to the original drug and a favorable safety profile.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49267410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21516/2072-0076-2023-16-2-119-123
S. Saakyan, D. A. Skladnev, A. P. Alekseeva, V. Sorokin, O. Beznos
Purpose: to compare the regenerative activity of benign and malignant conjunctival tumors.Material and methods. The study was performed on 86 tumor biopsies from patients with a clinically diagnosed conjunctival neoplasm. Healthy tissues from the same eye were taken as a control sample. The optical density of the reaction mixture containing biogenic nanoparticles formed in the presence of conjunctival tumors and the corresponding paired healthy tissue samples from the control group was measured by spectrophotometry. The data obtained were later verified by a pathohistological analysis.Results. A significantly higher level of in situ formation of biogenic silver nanoparticles was recorded in the reaction mixture with malignant tumors of the conjunctiva (3.0 ± 1.1, (n = 32) compared to benign tumors (1.3 ± 0.2, n = 54). No differences were found between various types of benign tumors. In samples of malignant tumors, the indicators of recovery activity in melanoma (3.4 ± 1.0, n = 14) and lymphoma (2.8 ± 1.0, n = 7) were significantly higher than in squamous cell carcinoma (2.0 ± 0.6, n = 11), but no significant differences were found between the two types of tumors.Conclusion. The method of spectrophotometric measurement of the regenerative activity of conjunctival tumors can be used in preoperative or intraoperative diagnostics thanks to the fact that the results can be obtained rapidly, which will help to quickly determine the extent of surgical intervention needed and optimize the treatment tactics.
{"title":"Possibilities of spectrometric diagnostics of benign and malignant conjunctival tumors","authors":"S. Saakyan, D. A. Skladnev, A. P. Alekseeva, V. Sorokin, O. Beznos","doi":"10.21516/2072-0076-2023-16-2-119-123","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-119-123","url":null,"abstract":"Purpose: to compare the regenerative activity of benign and malignant conjunctival tumors.Material and methods. The study was performed on 86 tumor biopsies from patients with a clinically diagnosed conjunctival neoplasm. Healthy tissues from the same eye were taken as a control sample. The optical density of the reaction mixture containing biogenic nanoparticles formed in the presence of conjunctival tumors and the corresponding paired healthy tissue samples from the control group was measured by spectrophotometry. The data obtained were later verified by a pathohistological analysis.Results. A significantly higher level of in situ formation of biogenic silver nanoparticles was recorded in the reaction mixture with malignant tumors of the conjunctiva (3.0 ± 1.1, (n = 32) compared to benign tumors (1.3 ± 0.2, n = 54). No differences were found between various types of benign tumors. In samples of malignant tumors, the indicators of recovery activity in melanoma (3.4 ± 1.0, n = 14) and lymphoma (2.8 ± 1.0, n = 7) were significantly higher than in squamous cell carcinoma (2.0 ± 0.6, n = 11), but no significant differences were found between the two types of tumors.Conclusion. The method of spectrophotometric measurement of the regenerative activity of conjunctival tumors can be used in preoperative or intraoperative diagnostics thanks to the fact that the results can be obtained rapidly, which will help to quickly determine the extent of surgical intervention needed and optimize the treatment tactics.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49236745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21516/2072-0076-2023-16-2-92-98
E. Tarutta
Purpose: evaluation of the remote functional and refractive results of mixed astigmatism correction in preschool children with “plus” cylinders in the framework of a long-time longitudinal study.Material and methods. 38 children (75 eyes) aged 1.5–7 years (averagely 4.2 years) with mixed astigmatism of 0.75 to 4.25 D (averagely 1.85 D) were followed up for 6-15 (averagely 7.3) years. At the first examination, all children were prescribed to permanently wear (+) cylinders of 0.5 D to 3.5 D. Over the follow-up period, (+) Cyl could be weakened in 24 eyes (32 %) due to a decrease in astigmatism, while (-) Sph had to be added in 24 eyes (32 %). due to an increased refraction. In cases when the full correction using a “plus” cylinder left an excessively large myopic defocus, the power of the “plus” cylinder was reduced so as not to add a “minus” sphere, and a second pair of glasses was prescribed for near vision, which offered a full correction of astigmatism with the “plus” cylinder.Results. After 6–15 years, astigmatism changed in 85 % of the examined eyes: it increased in 7 eyes (averagely, by 0.3 D) and decreased in 53 (averagely, by 0.9 D, p < 0.05; with the maximum reduction of 2.75 D). The spheric-equivalent refraction changed in 51 % of eyes, with an average increase of 0.53 D. The maximum increase of refraction was 2.8 D, while the maximum drop was 1.4 D. Visual acuity of the children who wore the prescribed eyeglasses permanently, showed after two years an increase, average achieving the level of 0.84, which by the end of the follow-up period achieved 0.99.Conclusion. The proposed plan of mixed astigmatism correction, which preserves residual weak myopic defocus, fully ensured both tactical and strategic effects: prevention and elimination of amblyopia, and containment of refraction myopization.
{"title":"Strategically oriented correction of mixed astigmatism in children","authors":"E. Tarutta","doi":"10.21516/2072-0076-2023-16-2-92-98","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-92-98","url":null,"abstract":"Purpose: evaluation of the remote functional and refractive results of mixed astigmatism correction in preschool children with “plus” cylinders in the framework of a long-time longitudinal study.Material and methods. 38 children (75 eyes) aged 1.5–7 years (averagely 4.2 years) with mixed astigmatism of 0.75 to 4.25 D (averagely 1.85 D) were followed up for 6-15 (averagely 7.3) years. At the first examination, all children were prescribed to permanently wear (+) cylinders of 0.5 D to 3.5 D. Over the follow-up period, (+) Cyl could be weakened in 24 eyes (32 %) due to a decrease in astigmatism, while (-) Sph had to be added in 24 eyes (32 %). due to an increased refraction. In cases when the full correction using a “plus” cylinder left an excessively large myopic defocus, the power of the “plus” cylinder was reduced so as not to add a “minus” sphere, and a second pair of glasses was prescribed for near vision, which offered a full correction of astigmatism with the “plus” cylinder.Results. After 6–15 years, astigmatism changed in 85 % of the examined eyes: it increased in 7 eyes (averagely, by 0.3 D) and decreased in 53 (averagely, by 0.9 D, p < 0.05; with the maximum reduction of 2.75 D). The spheric-equivalent refraction changed in 51 % of eyes, with an average increase of 0.53 D. The maximum increase of refraction was 2.8 D, while the maximum drop was 1.4 D. Visual acuity of the children who wore the prescribed eyeglasses permanently, showed after two years an increase, average achieving the level of 0.84, which by the end of the follow-up period achieved 0.99.Conclusion. The proposed plan of mixed astigmatism correction, which preserves residual weak myopic defocus, fully ensured both tactical and strategic effects: prevention and elimination of amblyopia, and containment of refraction myopization.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"30 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41258933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21516/2072-0076-2023-16-2-74-82
E. S. Pirogova, O. Fabrikantov, S. I. Nikolashin
Purpose: to develop new approaches to Morgagnian cataract surgery by optimizing the phacoemulsification technique and reducing the risk of surgical complications.Material and methods. 22 patients (22 eyes) with hypermature Morgagnian cataract were divided into 2 groups. The main group I included 11 patients who underwent surgery according to the PEC technology using iridocapsular retractors, an intracapsular ring and the scaffold technique with the last nucleus fragment relocated into the anterior chamber. The comparison group II included 11 patients with PEC and IOL implantation using iridocapsular retractors and an intracapsular ring with no scaffold technique involved. In 7 patients of group I, the lens nucleus was considered “large” and in 4 patients, “small”. In 8 patients of group II, the lens nucleus was considered “large” and in 3 patients, “small”.Results. After 6 months, BCVA in group I was 0.60, whilst in group II it was 0.70. IOP in group I averaged 12.9 mm Hg, while in group II it averaged 17.90 mm Hg. The endothelial cell density (CD) in group I decreased by 241 cells and amounted to 2012.0 cells/mm2 , the endothelial cell loss was 10.70%, while in group II CD loss was greater. It dropped by 377 cells (15.60%) and amounted to 2039 cells/mm2 .Conclusions. The severity of involutional changes in the ligamentous apparatus of the lens in Morgagnian cataract was found to depend on the nucleus size. A working classification of Morganian cataract by the nucleus size has been proposed. The use of scaffold technique with the relocation of the last fragment into the anterior chamber made it possible to reduce the share of surgical complications to 18.18%. During phacoemulsification of Morgagnian cataract with small nuclei, surgical complications took place in both group I and II, which necessitates further improvement of the existing surgical technique of this type of pathology.
{"title":"An improved technique for Morgagnian cataract phacoemulsification","authors":"E. S. Pirogova, O. Fabrikantov, S. I. Nikolashin","doi":"10.21516/2072-0076-2023-16-2-74-82","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-74-82","url":null,"abstract":"Purpose: to develop new approaches to Morgagnian cataract surgery by optimizing the phacoemulsification technique and reducing the risk of surgical complications.Material and methods. 22 patients (22 eyes) with hypermature Morgagnian cataract were divided into 2 groups. The main group I included 11 patients who underwent surgery according to the PEC technology using iridocapsular retractors, an intracapsular ring and the scaffold technique with the last nucleus fragment relocated into the anterior chamber. The comparison group II included 11 patients with PEC and IOL implantation using iridocapsular retractors and an intracapsular ring with no scaffold technique involved. In 7 patients of group I, the lens nucleus was considered “large” and in 4 patients, “small”. In 8 patients of group II, the lens nucleus was considered “large” and in 3 patients, “small”.Results. After 6 months, BCVA in group I was 0.60, whilst in group II it was 0.70. IOP in group I averaged 12.9 mm Hg, while in group II it averaged 17.90 mm Hg. The endothelial cell density (CD) in group I decreased by 241 cells and amounted to 2012.0 cells/mm2 , the endothelial cell loss was 10.70%, while in group II CD loss was greater. It dropped by 377 cells (15.60%) and amounted to 2039 cells/mm2 .Conclusions. The severity of involutional changes in the ligamentous apparatus of the lens in Morgagnian cataract was found to depend on the nucleus size. A working classification of Morganian cataract by the nucleus size has been proposed. The use of scaffold technique with the relocation of the last fragment into the anterior chamber made it possible to reduce the share of surgical complications to 18.18%. During phacoemulsification of Morgagnian cataract with small nuclei, surgical complications took place in both group I and II, which necessitates further improvement of the existing surgical technique of this type of pathology.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48418363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21516/2072-0076-2023-16-2-113-118
L. Balashova, N. A. Bakunina, A. Fedorov, Y. Kuznetsova, A. Popov, M. E. Viner
Purpose: clinical and genetic research of primary chronic angle-closure glaucoma (PACG) and age-related macular degeneration (AMD) for prospective pathogenetically-oriented targeted treatment of these condition.Materials and methods. 15 patients with isolated ocular proliferative syndrome were divided into 2 groups depending on their diagnosis: 1) 7 patients (14 eyes) aged 55 to 83 with confirmed wet AMD (4 women and 3 men). 2) 8 patients (16 eyes) aged 45 to 80 with chronic PACG (5 women and 3 men). The patients were followed up for 1 to 3 years.Results. In both conditions, we found mutations in the genes of the Russian population involved in the process of proliferation: VEGF A, CFH, and COL11A1. We developed an algorithm of bioinformatic analysis of full-exome/full-genome sequencing data which takes account of the aggregate of clinical and genetic data and helps refine the prognosis of the course of proliferation. Genetic markers remain unchanged throughout the patient’s life, so it is important to conduct these studies in old age.Conclusion. To prevent the proliferative syndrome in patients with chronic PACG and AMD, and develop individual targeted pathogenetic therapy schemes for these diseases, specialized molecular genetic tests are needed, the results of which could be analyzed with the developed algorithm.
{"title":"Genetic markers of the proliferative syndrome in age-related macular degeneration and chronic angle-closure glaucoma","authors":"L. Balashova, N. A. Bakunina, A. Fedorov, Y. Kuznetsova, A. Popov, M. E. Viner","doi":"10.21516/2072-0076-2023-16-2-113-118","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-113-118","url":null,"abstract":"Purpose: clinical and genetic research of primary chronic angle-closure glaucoma (PACG) and age-related macular degeneration (AMD) for prospective pathogenetically-oriented targeted treatment of these condition.Materials and methods. 15 patients with isolated ocular proliferative syndrome were divided into 2 groups depending on their diagnosis: 1) 7 patients (14 eyes) aged 55 to 83 with confirmed wet AMD (4 women and 3 men). 2) 8 patients (16 eyes) aged 45 to 80 with chronic PACG (5 women and 3 men). The patients were followed up for 1 to 3 years.Results. In both conditions, we found mutations in the genes of the Russian population involved in the process of proliferation: VEGF A, CFH, and COL11A1. We developed an algorithm of bioinformatic analysis of full-exome/full-genome sequencing data which takes account of the aggregate of clinical and genetic data and helps refine the prognosis of the course of proliferation. Genetic markers remain unchanged throughout the patient’s life, so it is important to conduct these studies in old age.Conclusion. To prevent the proliferative syndrome in patients with chronic PACG and AMD, and develop individual targeted pathogenetic therapy schemes for these diseases, specialized molecular genetic tests are needed, the results of which could be analyzed with the developed algorithm.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49201635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.21516/2072-0076-2023-16-2-47-53
V. Neroev, E. Tarutta, N. Khodzhabekyan, A. T. Khandzhian, S. Harutyunyan
Purpose: to compare anatomical and optical parameters and aberrations of both eyes in patients with acquired and congenital anisometropic myopia.Material and methods. 22 patients (44 eyes) aged 18–35 (averagely, 25.2) with acquired and congenital anisometropic myopia were examined using the Galilei G6 optical eye system analyzer (Ziemer, Switzerland). The analysis of total, corneal and internal aberrations of the eye was carried out on an OPD-Scan III (Nidek) aberrometer.Results. In both groups with acquired and congenital anisometropic myopia, the axial length of the higher myopic eye was greater than that of the fellow eye. A greater asphericity and higher astigmatism of the cornea were revealed in higher myopic eyes of patients with congenital myopia as compared to acquired myopia. The total RMS HOA in congenital myopia was significantly greater in the higher myopic eye compared to the fellow eye (1.07 D and 0.68 D, respectively) and greater than in cases of acquired myopia. All HOA were greater in higher myopic eyes as compared to the fellow ones in cases of congenital myopia. In case of acquired myopia only the total coma appeared to be greater in the higher myopic eye. Corneal aberrations in acquired anisometropic myopia did not differ in the paired eyes. In case of congenital myopia, the total tilt was significantly greater in the higher myopic eye, and total coma and spherical aberration have lower values, even with a transition to negative ones (p < 0.05).Conclusion. The revealed differences of the wavefront of the eyes with anisometropic congenital and acquired myopia are rather a consequence of anatomical and optical differences (the axial length of the eyes and the topography of the cornea), than the cause of anisometropia.
目的:比较后天性和先天性屈光参差性近视的解剖光学参数和双眼像差。材料和方法。采用瑞士Ziemer公司的Galilei G6光学眼系统分析仪对22例(44眼)18-35岁的获得性和先天性屈光参差性近视患者(平均25.2眼)进行检查。在OPD-Scan III (Nidek)像差仪上分析了眼睛的总像差、角膜像差和内部像差。在获得性和先天性屈光参差近视两组中，远视眼的眼轴长度均大于同近视眼。先天性高度近视患者的角膜非球面性和散光明显高于后天性近视。先天性近视高近视眼的总RMS HOA显著高于同近视眼(分别为1.07 D和0.68 D)，且显著高于后天性近视。高度近视患者的HOA均高于先天性近视患者。在获得性近视的情况下，只有高度近视眼的总昏迷更大。获得性屈光参差近视的角膜像差在配对眼中无差异。在先天性近视中，高度近视眼的总倾斜度显著大于高度近视眼，总昏迷和球差值较低，甚至有向负值过渡的趋势(p < 0.05)。屈光参差的先天性近视和后天性近视的波前差异，与其说是屈光参差的原因，不如说是解剖和光学差异(眼轴长度和角膜地形)的结果。
{"title":"Anatomical and optical parameters and aberrations of the optical system of the eye in anisometropic myopia","authors":"V. Neroev, E. Tarutta, N. Khodzhabekyan, A. T. Khandzhian, S. Harutyunyan","doi":"10.21516/2072-0076-2023-16-2-47-53","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-47-53","url":null,"abstract":"Purpose: to compare anatomical and optical parameters and aberrations of both eyes in patients with acquired and congenital anisometropic myopia.Material and methods. 22 patients (44 eyes) aged 18–35 (averagely, 25.2) with acquired and congenital anisometropic myopia were examined using the Galilei G6 optical eye system analyzer (Ziemer, Switzerland). The analysis of total, corneal and internal aberrations of the eye was carried out on an OPD-Scan III (Nidek) aberrometer.Results. In both groups with acquired and congenital anisometropic myopia, the axial length of the higher myopic eye was greater than that of the fellow eye. A greater asphericity and higher astigmatism of the cornea were revealed in higher myopic eyes of patients with congenital myopia as compared to acquired myopia. The total RMS HOA in congenital myopia was significantly greater in the higher myopic eye compared to the fellow eye (1.07 D and 0.68 D, respectively) and greater than in cases of acquired myopia. All HOA were greater in higher myopic eyes as compared to the fellow ones in cases of congenital myopia. In case of acquired myopia only the total coma appeared to be greater in the higher myopic eye. Corneal aberrations in acquired anisometropic myopia did not differ in the paired eyes. In case of congenital myopia, the total tilt was significantly greater in the higher myopic eye, and total coma and spherical aberration have lower values, even with a transition to negative ones (p < 0.05).Conclusion. The revealed differences of the wavefront of the eyes with anisometropic congenital and acquired myopia are rather a consequence of anatomical and optical differences (the axial length of the eyes and the topography of the cornea), than the cause of anisometropia.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46418861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.21516/2072-0076-2023-16-2-54-62
N. V. Neroeva, O. V. Zaytseva, T. D. Okhotsimskaya, N. Shvetsova, O. I. Markelova
Disorders of ocular perfusion are associated with huge amout of diseases, including such socially significant as diabetic retinopathy and glaucoma. To date, there is no gold standard for measuring ocular perfusion. An innovative method for two-dimensional assessment of eye blood flow — laser speckle flowgraphy (LSFG) — has been developed recent years and implemented in ophthalmological practice.Purpose: to evaluate the possibilities of LSFG for determining ocular blood flow and to find out the age dependence of the obtained indicators of ocular blood flow.Materials and methods. The study includes 60 healthy volunteers. The examined persons were divided into 3 groups of 20 people depending on their age — 20–40 years old, 41–60 years old, and over 61 years old. All examined persons had high visual acuity and normal blood pressure. The study was carried out on an LSFG-RetFlow device (Nidek). The shape of the pulse wave, its qualitative and quantitative characteristics including the main parameter of LSFG - MBR (Mean Blur Rate) were determined.Results. A significant decrease with age of most studied parameters of blood flow volume was revealed, the changes were significant (p £ 0.05). The highest MBR parameters were noted in the group of 20–40 years old. In the macular area, MBR values decreased more significantly in the group after 60 years age, while for the optic nerve head (ONH), a decrease has been already noted after 40 years age. In average, the decrease was 25–34 % for the ONH area and 33–38 % for the macular area. Changes of the other parameters of the pulse waveform had a similar trend.Conclusion. LSFG is a reliable method for quantifying ocular blood flow. Our data support that LSFG-derived MBR and pulse wave measurements may be useful biomarkers for ocular perfusion changes. The identified age-related blood flow changes should be taken into account during the analysis of patients data.
{"title":"Age-related changes of ocular blood flow detecting by laser speckle flowgraphy","authors":"N. V. Neroeva, O. V. Zaytseva, T. D. Okhotsimskaya, N. Shvetsova, O. I. Markelova","doi":"10.21516/2072-0076-2023-16-2-54-62","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-54-62","url":null,"abstract":"Disorders of ocular perfusion are associated with huge amout of diseases, including such socially significant as diabetic retinopathy and glaucoma. To date, there is no gold standard for measuring ocular perfusion. An innovative method for two-dimensional assessment of eye blood flow — laser speckle flowgraphy (LSFG) — has been developed recent years and implemented in ophthalmological practice.Purpose: to evaluate the possibilities of LSFG for determining ocular blood flow and to find out the age dependence of the obtained indicators of ocular blood flow.Materials and methods. The study includes 60 healthy volunteers. The examined persons were divided into 3 groups of 20 people depending on their age — 20–40 years old, 41–60 years old, and over 61 years old. All examined persons had high visual acuity and normal blood pressure. The study was carried out on an LSFG-RetFlow device (Nidek). The shape of the pulse wave, its qualitative and quantitative characteristics including the main parameter of LSFG - MBR (Mean Blur Rate) were determined.Results. A significant decrease with age of most studied parameters of blood flow volume was revealed, the changes were significant (p £ 0.05). The highest MBR parameters were noted in the group of 20–40 years old. In the macular area, MBR values decreased more significantly in the group after 60 years age, while for the optic nerve head (ONH), a decrease has been already noted after 40 years age. In average, the decrease was 25–34 % for the ONH area and 33–38 % for the macular area. Changes of the other parameters of the pulse waveform had a similar trend.Conclusion. LSFG is a reliable method for quantifying ocular blood flow. Our data support that LSFG-derived MBR and pulse wave measurements may be useful biomarkers for ocular perfusion changes. The identified age-related blood flow changes should be taken into account during the analysis of patients data.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47053591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.21516/2072-0076-2023-16-2-33-39
A. Myagkov, P. Rozental
The improvement in nursing routine of premature babies with low and extremely low body weight has increased their survival rate. Along with the growing number of such children, retinopathy of prematurity (ROP) occurs relatively less often and its outcome becomes more favorable. Modern approaches to the surgical treatment have led to a significant reduction in the incidence of blindness and visual disability caused by ROP. Yet, ROP remains one of the major issues in neonatal ophthalmology, often associated with refractive disorders.Purpose: to evaluate the refractive changes in children with ROP after transpupillary laser coagulation of the retina based by clinical experience.Materials and methods. We analyzed 5 clinical cases of children with ROP treated in Children's City Clinical Hospital No 1 during the period from 2013 to 2014. All patients underwent retinal transpupillary laser coagulation; its volume determined by the stage of ROP. Eye refraction data were noted at the age of 1 and 7 years. The quality of visual functions and the axial length of the eye were determined at the age of 7.Results. All patients had hyperopia of varying degrees at 1 years old. By the age of 7, one patient developed myopia, another one had emmetropia, while the rest of children had hyperopia of varying degrees. Regardless of the refractive error type, the axial length of the eye remained significantly below the age norm. The low quality of visual functions is due to the lack of full-time optical correction and irregular outpatient observation.Conclusions. Most often, hyperopia refraction in children with ROP is accompanied by a short axial length of the eye. Full-time optical correction should be prescribed, and spectacle wearing should be monitored by parents and ophthalmologists who observe the patients.
{"title":"Refraction changes in children with retinopathy of prematurity after transpupillary laser coagulation of the retina","authors":"A. Myagkov, P. Rozental","doi":"10.21516/2072-0076-2023-16-2-33-39","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-33-39","url":null,"abstract":"The improvement in nursing routine of premature babies with low and extremely low body weight has increased their survival rate. Along with the growing number of such children, retinopathy of prematurity (ROP) occurs relatively less often and its outcome becomes more favorable. Modern approaches to the surgical treatment have led to a significant reduction in the incidence of blindness and visual disability caused by ROP. Yet, ROP remains one of the major issues in neonatal ophthalmology, often associated with refractive disorders.Purpose: to evaluate the refractive changes in children with ROP after transpupillary laser coagulation of the retina based by clinical experience.Materials and methods. We analyzed 5 clinical cases of children with ROP treated in Children's City Clinical Hospital No 1 during the period from 2013 to 2014. All patients underwent retinal transpupillary laser coagulation; its volume determined by the stage of ROP. Eye refraction data were noted at the age of 1 and 7 years. The quality of visual functions and the axial length of the eye were determined at the age of 7.Results. All patients had hyperopia of varying degrees at 1 years old. By the age of 7, one patient developed myopia, another one had emmetropia, while the rest of children had hyperopia of varying degrees. Regardless of the refractive error type, the axial length of the eye remained significantly below the age norm. The low quality of visual functions is due to the lack of full-time optical correction and irregular outpatient observation.Conclusions. Most often, hyperopia refraction in children with ROP is accompanied by a short axial length of the eye. Full-time optical correction should be prescribed, and spectacle wearing should be monitored by parents and ophthalmologists who observe the patients.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42330866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.21516/2072-0076-2023-16-2-22-27
M. Kovalevskaya, V. B. Antonyan, M. I. Sergeeva
Purpose: to evaluate the impact of Optinol treatment on the ocular surface state in medical students with various types of ametropia.Material and methods. The study involved 3 groups of patients: two clinical groups and a control group. The first clinical group consisted of 34 students (68 eyes) with mild, moderate or high hyperopia, averagely aged 20.1 ± 0.5 years. The second clinical group consisted of 47 students (94 eyes) with mild, moderate or high myopia, average aged 20.6 ± 0.9 years. The control group was composed of 60 students (120 eyes), averagely aged 21.4 ± 1.2 years, with no ophthalmic pathologies. Each group received Optinol consecutively in three different formulations: Optinol® Gentle Repair: dexpanthenol 2 % and sodium hyaluronate 0.15 %, Optinol® Deep Hydration: sodium hyaluronate 0.4 %, Optinol® Express Moisturizer: sodium hyaluronate 0.21 %. The case histories of the patients and typical complaints were revealed by the questionnaire method. The state of the eyelids and the conjunctiva was assessed by biomicroscopy. To diagnose the dry eye syndrome (DES), special tests were used: LIPKOF, Schirmer and Norn tests.Results. Despite the higher LIPKOF scores in the 1st (hyperopic) group, showing stage III as compared to the 2nd (myopic) group where it scored stage I, the Norn test score showed a stronger reduction in the 2nd group. The LIPKOF test improved in the hyperopic group, falling to 1.23 ± 0.10 mm (stage I), which corresponded to one conjunctival fold. The index of tear film stability (Norn's test) increased in group 1 by 3.1 ± 0.1 sec, and in group 2 by 2.2 ± 0.2 sec.Conclusion. DES was found to be more frequent in hyperopic students. Optinol is a pathogenetically oriented drug, targeting tear production disorders and ocular surface changes. The drug demonstrates high efficacy, good tolerability and safety profile, so that it could be recommended for managing multiple types of ametropia.
{"title":"Possibilities of dry eye syndrome therapy in various types of ametropia","authors":"M. Kovalevskaya, V. B. Antonyan, M. I. Sergeeva","doi":"10.21516/2072-0076-2023-16-2-22-27","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-2-22-27","url":null,"abstract":"Purpose: to evaluate the impact of Optinol treatment on the ocular surface state in medical students with various types of ametropia.Material and methods. The study involved 3 groups of patients: two clinical groups and a control group. The first clinical group consisted of 34 students (68 eyes) with mild, moderate or high hyperopia, averagely aged 20.1 ± 0.5 years. The second clinical group consisted of 47 students (94 eyes) with mild, moderate or high myopia, average aged 20.6 ± 0.9 years. The control group was composed of 60 students (120 eyes), averagely aged 21.4 ± 1.2 years, with no ophthalmic pathologies. Each group received Optinol consecutively in three different formulations: Optinol® Gentle Repair: dexpanthenol 2 % and sodium hyaluronate 0.15 %, Optinol® Deep Hydration: sodium hyaluronate 0.4 %, Optinol® Express Moisturizer: sodium hyaluronate 0.21 %. The case histories of the patients and typical complaints were revealed by the questionnaire method. The state of the eyelids and the conjunctiva was assessed by biomicroscopy. To diagnose the dry eye syndrome (DES), special tests were used: LIPKOF, Schirmer and Norn tests.Results. Despite the higher LIPKOF scores in the 1st (hyperopic) group, showing stage III as compared to the 2nd (myopic) group where it scored stage I, the Norn test score showed a stronger reduction in the 2nd group. The LIPKOF test improved in the hyperopic group, falling to 1.23 ± 0.10 mm (stage I), which corresponded to one conjunctival fold. The index of tear film stability (Norn's test) increased in group 1 by 3.1 ± 0.1 sec, and in group 2 by 2.2 ± 0.2 sec.Conclusion. DES was found to be more frequent in hyperopic students. Optinol is a pathogenetically oriented drug, targeting tear production disorders and ocular surface changes. The drug demonstrates high efficacy, good tolerability and safety profile, so that it could be recommended for managing multiple types of ametropia.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46056664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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