Pub Date : 2023-10-11DOI: 10.21516/2072-0076-2023-16-3-81-86
T. D. Sizova, V. M. Khokkanen, E. V. Boiko
Effective treatment of HIV-infected patients has changed the previous view of the clinical picture of cytomegalovirus uveitis (CMV uveitis). Purpose : to determine the prevalence and structure of clinical forms of CMV uveitis in HIV-infected patients. Material and methods . 66 patients (97 eyes), aged 39.6 ± 3.91, were diagnosed with stage 4c HIV infection. In 35 patients (53%), the duration of infection exceeded 5 years, in 13 patients (19.7%), it exceeded 10 years, and another 13 patients (19.7%) had the condition for over 15 years. The ophthalmological follow-up of patients diagnosed with CMV uveitis ranged from 6 months to 13 years (the median of 45.5 months). Results . By the time CMV uveitis was detected, the median CD4 cell count was 34 cells/μL (the norm being 570–1100 cells/μL). The content of whole blood CMV DNA was 2.43 lg copies/10 5 cells. The main form of the disease was chorioretinitis, diffuse and generalized forms of the disease were diagnosed in 68.0% of cases. In predicting visual acuity, the leading regression criterion was the clinical form of the disease. Conclusion . Diffuse and generalized forms of the disease prevailed in clinical practice. The prevalence of chorioretinal lesion determined visual acuity, which in 39.2% of the eyes met the criteria for blindness according to the WHO classification (1977)
{"title":"Cytomegalovirus uveitis in HIV-infected patients: the main clinical forms","authors":"T. D. Sizova, V. M. Khokkanen, E. V. Boiko","doi":"10.21516/2072-0076-2023-16-3-81-86","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-81-86","url":null,"abstract":"Effective treatment of HIV-infected patients has changed the previous view of the clinical picture of cytomegalovirus uveitis (CMV uveitis). Purpose : to determine the prevalence and structure of clinical forms of CMV uveitis in HIV-infected patients. Material and methods . 66 patients (97 eyes), aged 39.6 ± 3.91, were diagnosed with stage 4c HIV infection. In 35 patients (53%), the duration of infection exceeded 5 years, in 13 patients (19.7%), it exceeded 10 years, and another 13 patients (19.7%) had the condition for over 15 years. The ophthalmological follow-up of patients diagnosed with CMV uveitis ranged from 6 months to 13 years (the median of 45.5 months). Results . By the time CMV uveitis was detected, the median CD4 cell count was 34 cells/μL (the norm being 570–1100 cells/μL). The content of whole blood CMV DNA was 2.43 lg copies/10 5 cells. The main form of the disease was chorioretinitis, diffuse and generalized forms of the disease were diagnosed in 68.0% of cases. In predicting visual acuity, the leading regression criterion was the clinical form of the disease. Conclusion . Diffuse and generalized forms of the disease prevailed in clinical practice. The prevalence of chorioretinal lesion determined visual acuity, which in 39.2% of the eyes met the criteria for blindness according to the WHO classification (1977)","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136253663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-11DOI: 10.21516/2072-0076-2023-16-3-118-126
N. A. Bakunina, L. M. Balashova
Purpose : to clarify the pathogenetic classification of primary angle-closure glaucoma (PACG) based on genetic studies and retrospective analysis. Material and methods . 28 patients (44 eyes) aged 40 to 75 years with various forms of initial, advanced, advanced and terminal stages of PACG, as well as combined glaucoma, were observed. Results . Pathogenetically significant genetic polymorphisms responsible for synechiogenesis in chronic PACG have been found. Clinical and genetic analysis of PACG showed that the classification based on the clinical course, the mechanisms of closure of the iridocorneal angle (ICA), the distribution by stages of primary closure of the ICA, the severity of the pathological process and the level of intraocular pressure, fail to take into account the genetic characteristics of patients with PACG: these are predetermined at birth. In appositional closure of the ICA, preventive laser iridotomy is indicated, while in synechial closure, preventive iridotomy may aggravate synechiogenesis. Conclusion . A pathogenetic classification of PACG has been proposed, which takes account of its hereditary nature. This classification, is advisable to use when choosing a treatment tactics.
{"title":"On the pathogenetic classification of primary angleclosure glaucoma","authors":"N. A. Bakunina, L. M. Balashova","doi":"10.21516/2072-0076-2023-16-3-118-126","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-118-126","url":null,"abstract":"Purpose : to clarify the pathogenetic classification of primary angle-closure glaucoma (PACG) based on genetic studies and retrospective analysis. Material and methods . 28 patients (44 eyes) aged 40 to 75 years with various forms of initial, advanced, advanced and terminal stages of PACG, as well as combined glaucoma, were observed. Results . Pathogenetically significant genetic polymorphisms responsible for synechiogenesis in chronic PACG have been found. Clinical and genetic analysis of PACG showed that the classification based on the clinical course, the mechanisms of closure of the iridocorneal angle (ICA), the distribution by stages of primary closure of the ICA, the severity of the pathological process and the level of intraocular pressure, fail to take into account the genetic characteristics of patients with PACG: these are predetermined at birth. In appositional closure of the ICA, preventive laser iridotomy is indicated, while in synechial closure, preventive iridotomy may aggravate synechiogenesis. Conclusion . A pathogenetic classification of PACG has been proposed, which takes account of its hereditary nature. This classification, is advisable to use when choosing a treatment tactics.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136253664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-11DOI: 10.21516/2072-0076-2023-16-3-100-103
D. O. Shkvorchenko, K. S. Norman, E. S. Khrisanfova, A. Yu. Kornienko, B. A. Kasygulova
Purpose : to present our experience of surgical treatment of peripheral retinoschisis without macular involvement using a scleral buckle. Material and methods . 31 patients (31 eyes) with peripheral retinoschisis (PR) without macular involvement, including 19 cases complicated by retinal detachment, underwent scleral buckling with cryoretinopexy of rupture zones and vitreoretinal degeneration and transscleral drainage of subretinal fluid. Results . In 12 (39 %) cases, the retina reattached within 24 hours after the operation, in 11 (35 %) cases, it reattached within 1 week, while in 8 (26 %) cases complete resorption of the subretinal fluid and retinal reattachment occurred 1 to 6 months after the operation. By the end of the 6-month follow-up period, retinal reattachment was achieved in all cases. Conclusion . The surgical treatment tactics of PR without macular involvement by scleral buckling is effective and pathogenetically validated, especially in the case of progressing lretinoschisis.
{"title":"Our experience of surgical treatment of peripheral retinoschisis without capturing the macular zone using scleral buckling","authors":"D. O. Shkvorchenko, K. S. Norman, E. S. Khrisanfova, A. Yu. Kornienko, B. A. Kasygulova","doi":"10.21516/2072-0076-2023-16-3-100-103","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-100-103","url":null,"abstract":"Purpose : to present our experience of surgical treatment of peripheral retinoschisis without macular involvement using a scleral buckle. Material and methods . 31 patients (31 eyes) with peripheral retinoschisis (PR) without macular involvement, including 19 cases complicated by retinal detachment, underwent scleral buckling with cryoretinopexy of rupture zones and vitreoretinal degeneration and transscleral drainage of subretinal fluid. Results . In 12 (39 %) cases, the retina reattached within 24 hours after the operation, in 11 (35 %) cases, it reattached within 1 week, while in 8 (26 %) cases complete resorption of the subretinal fluid and retinal reattachment occurred 1 to 6 months after the operation. By the end of the 6-month follow-up period, retinal reattachment was achieved in all cases. Conclusion . The surgical treatment tactics of PR without macular involvement by scleral buckling is effective and pathogenetically validated, especially in the case of progressing lretinoschisis.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136253960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-11DOI: 10.21516/2072-0076-2023-16-3-111-117
M. Abd El Latief Fathallah, R. M. Abdel-Hamid, S. H. Salah, A. F. El-Shiaty, O. M. El-Zawahry
Purpose . To evaluate the efficacy and safety profile of an innovative ab-externo technique in the management of uncontrolled open angle glaucoma (OAG) through creating filtering tracts subconjunctivally. Material and methods . This is a randomized clinical trial including 40 eyes (40 patients) divided into 2 equal groups, group (A), underwent ab-externo radiofrequency sclerostomy and group (B), underwent ab-externo radiofrequency sclerostomy with subconjunctival injection of mitomycin C. Intraoperative and postoperative complications, visual acuity, intraocular pressure (IOP) and bleb status were evaluated for 6 months. Results . The mean preoperative IOP was 28 ± 3.5 mm Hg reduced to 21.9 ± 5.2 mm Hg (p = 0.001) in group (A) and was 29.4 ± 3.4 mm Hg reduced to 20.8 ± 6.3 mm Hg (p = 0.001) in group (B), 6 months postoperatively. Both groups showed a significant percent reduction of IOP 15.1 ± 17.3%, 27.1 ± 22.4% in groups (A) and (B) respectively with group (B) showing lower values on days 1, 7, 14, 30, 90 and 180 but was not statistically significant. The number of anti-glaucoma medications was significantly reduced in both groups. Heat radiation to the cornea from radiofrequency waves was obvious in early cases — 5 (25%) in group (A), and 3 (15%) in group (B) that was reversible within the first 3 months postoperatively. Shallow anterior chamber and choroidal detachment were the most encountered early postoperative complication, which all managed conservatively. Conclusion . Ab-externo radiofrequency sclerostomy offers a promising minimally invasive, quick and simple procedure in management of early and moderate cases of OAG with effective reduction of IOP and number of glaucoma medication.
目的。目的评价一种创新的ab- external技术通过结膜下滤过束治疗非控制开角型青光眼(OAG)的有效性和安全性。材料和方法。这是一项随机临床试验，包括40只眼(40例患者)，分为2个相等的组，a组行ab-外射频巩膜造口术，B组行ab-外射频巩膜造口术并结膜下注射丝裂霉素c，为期6个月，评估术中及术后并发症、视力、眼压(IOP)和水肿状况。结果。术后6个月，A组平均IOP由28±3.5 mm Hg降至21.9±5.2 mm Hg (p = 0.001)， B组平均IOP由29.4±3.4 mm Hg降至20.8±6.3 mm Hg (p = 0.001)。(a)组和(B)组IOP分别下降15.1±17.3%、27.1±22.4%，其中(B)组在第1、7、14、30、90、180天IOP下降，但差异无统计学意义。两组抗青光眼药物的使用数量均显著减少。在早期病例中，射频波对角膜的热辐射是明显的——A组有5例(25%)，B组有3例(15%)，这些热辐射在术后3个月内是可逆的。浅前房和脉络膜脱离是术后早期最常见的并发症，均采用保守治疗。结论。ab -外部射频硬化造口术是一种微创、快速、简单的治疗早期和中度OAG的方法，可有效降低眼压和青光眼药物治疗次数。
{"title":"Efficacy and safety of ab-externo radiofrequency sclerostomy in management of open-angle glaucoma","authors":"M. Abd El Latief Fathallah, R. M. Abdel-Hamid, S. H. Salah, A. F. El-Shiaty, O. M. El-Zawahry","doi":"10.21516/2072-0076-2023-16-3-111-117","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-111-117","url":null,"abstract":"Purpose . To evaluate the efficacy and safety profile of an innovative ab-externo technique in the management of uncontrolled open angle glaucoma (OAG) through creating filtering tracts subconjunctivally. Material and methods . This is a randomized clinical trial including 40 eyes (40 patients) divided into 2 equal groups, group (A), underwent ab-externo radiofrequency sclerostomy and group (B), underwent ab-externo radiofrequency sclerostomy with subconjunctival injection of mitomycin C. Intraoperative and postoperative complications, visual acuity, intraocular pressure (IOP) and bleb status were evaluated for 6 months. Results . The mean preoperative IOP was 28 ± 3.5 mm Hg reduced to 21.9 ± 5.2 mm Hg (p = 0.001) in group (A) and was 29.4 ± 3.4 mm Hg reduced to 20.8 ± 6.3 mm Hg (p = 0.001) in group (B), 6 months postoperatively. Both groups showed a significant percent reduction of IOP 15.1 ± 17.3%, 27.1 ± 22.4% in groups (A) and (B) respectively with group (B) showing lower values on days 1, 7, 14, 30, 90 and 180 but was not statistically significant. The number of anti-glaucoma medications was significantly reduced in both groups. Heat radiation to the cornea from radiofrequency waves was obvious in early cases — 5 (25%) in group (A), and 3 (15%) in group (B) that was reversible within the first 3 months postoperatively. Shallow anterior chamber and choroidal detachment were the most encountered early postoperative complication, which all managed conservatively. Conclusion . Ab-externo radiofrequency sclerostomy offers a promising minimally invasive, quick and simple procedure in management of early and moderate cases of OAG with effective reduction of IOP and number of glaucoma medication.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136253511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-11DOI: 10.21516/2072-0076-2023-16-3-87-93
R. R. Fayzrakhmanov, M. M. Shishkin, M. E. Kalinin, O. A. Pavlovsky
Purpose : to assess morphological and functional parameters of the eyeball in patients with neovascular glaucoma (NVG) and diabetic macular edema (DME) after vitreoretinal interventions. Material and methods . This study involved 60 patients (60 eyes), aged 59 ± 12 including 34 men and 26 women. The patients were divided into three groups: group 1 — 19 patients (19 eyes) with NVG and DME after a vitreoretinal surgery (VRS) for proliferative diabetic retinopathy performed no earlier than a year ago. If DME was found within 6 months after the surgery, a drug was administered intravitreally (3 loading injections given with monthly intervals). The patients’ history contained cataract phacoemulsification with an implantation of an intraocular lens (IOL). Group 2 (23 patients, 23 eyes) consisted of persons with stage III primary open-angle glaucoma (POAG) with the duration of the glaucomatous process of up to 5 years, who received no laser or surgical antiglaucomatous interventions. The history of these patients also contained phacoemulsification operations with IOL implantation. Group 3 (18 patients, 18 eyes), which was composed of patients with pseudophakia but no symptoms of glaucoma or other eye pathology, served as control. Results . The opening of the anterior chamber angle (ACA) in NVG (group 1) was 2.73 times smaller (p = 0.034) than in POAG (Group 2) and 3.69 times smaller than in the control group (p = 0.034). Neovascularization of the iris and the ACA could primarily be seen in patients with NVG (84 %). Goniosynechiae in the ACA of group 1 patients were seen 6.35 times more often than in group 2 patients and 14.45 times more often than in group 3 patients. Rubeosis occurred in group 1 patients 4.65 times as often as in group 2 and 6.64 times more often than in group 3 patients (p = 0.034). Statistically significant differences of morphometric parameters of the optic disc between groups 1 and 2, on the one hand, and group 3, on the other hand were found. Meanwhile, the figures for groups 1 and 2 were statistically comparable, which is explained by the same degree of severity of the glaucomatous process in these groups. The analysis of indices of computer perimetry MD, MS and sLV showed a developed glaucomatous process in groups 1 and 2. The revealed changes are based on pathognomonic factors. In particular, they may be caused by the prior surgical intervention affecting the vitreoretinal interface in group 1 patients. Conclusion . The onset of NVG is primarily caused by a grave course of proliferative diabetic and changes in the ACA profile, due to the formation of synechiae. Regardless of the risk factors, the result of surgical treatment depends on the condition of the ischemic retina and the anterior segment of the eye. Thus, the assessment of the morphofunctional parameters of the eye in patients with NVG and DME after VRS is of great interest. Changes in such parameters as the degree of openness of the ACA, distance from the iris to the
{"title":"Changes in the morphofunctional parameters of the eye in neovascular glaucoma on the after vitreoretinal surgery","authors":"R. R. Fayzrakhmanov, M. M. Shishkin, M. E. Kalinin, O. A. Pavlovsky","doi":"10.21516/2072-0076-2023-16-3-87-93","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-87-93","url":null,"abstract":"Purpose : to assess morphological and functional parameters of the eyeball in patients with neovascular glaucoma (NVG) and diabetic macular edema (DME) after vitreoretinal interventions. Material and methods . This study involved 60 patients (60 eyes), aged 59 ± 12 including 34 men and 26 women. The patients were divided into three groups: group 1 — 19 patients (19 eyes) with NVG and DME after a vitreoretinal surgery (VRS) for proliferative diabetic retinopathy performed no earlier than a year ago. If DME was found within 6 months after the surgery, a drug was administered intravitreally (3 loading injections given with monthly intervals). The patients’ history contained cataract phacoemulsification with an implantation of an intraocular lens (IOL). Group 2 (23 patients, 23 eyes) consisted of persons with stage III primary open-angle glaucoma (POAG) with the duration of the glaucomatous process of up to 5 years, who received no laser or surgical antiglaucomatous interventions. The history of these patients also contained phacoemulsification operations with IOL implantation. Group 3 (18 patients, 18 eyes), which was composed of patients with pseudophakia but no symptoms of glaucoma or other eye pathology, served as control. Results . The opening of the anterior chamber angle (ACA) in NVG (group 1) was 2.73 times smaller (p = 0.034) than in POAG (Group 2) and 3.69 times smaller than in the control group (p = 0.034). Neovascularization of the iris and the ACA could primarily be seen in patients with NVG (84 %). Goniosynechiae in the ACA of group 1 patients were seen 6.35 times more often than in group 2 patients and 14.45 times more often than in group 3 patients. Rubeosis occurred in group 1 patients 4.65 times as often as in group 2 and 6.64 times more often than in group 3 patients (p = 0.034). Statistically significant differences of morphometric parameters of the optic disc between groups 1 and 2, on the one hand, and group 3, on the other hand were found. Meanwhile, the figures for groups 1 and 2 were statistically comparable, which is explained by the same degree of severity of the glaucomatous process in these groups. The analysis of indices of computer perimetry MD, MS and sLV showed a developed glaucomatous process in groups 1 and 2. The revealed changes are based on pathognomonic factors. In particular, they may be caused by the prior surgical intervention affecting the vitreoretinal interface in group 1 patients. Conclusion . The onset of NVG is primarily caused by a grave course of proliferative diabetic and changes in the ACA profile, due to the formation of synechiae. Regardless of the risk factors, the result of surgical treatment depends on the condition of the ischemic retina and the anterior segment of the eye. Thus, the assessment of the morphofunctional parameters of the eye in patients with NVG and DME after VRS is of great interest. Changes in such parameters as the degree of openness of the ACA, distance from the iris to the ","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136253513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-11DOI: 10.21516/2072-0076-2023-16-3-104-110
E. V. Yani, T. G. Kamenskikh, E. V. Veselova, T. G. Zubkova, S. V. Stovbun, K. E. Seliverstova, V. V. Pozdnyakova, M. M. Stupakova
Ophthalmic herpes is the most common infection-related cause of blindness in developing countries. Purpose : to evaluate the therapeutic efficacy, safety and tolerability of the drug Panavir® used as part of a combination therapy for herpetic superficial dendritic keratitis. Materials and methods . The study involved 106 patients aged 18 to 65 years divided into two groups. Group 1 (54 patients; 54 eyes) received treatment with Panavir® and Acyclovir ophthalmic ointment, whilst Group 2 (52 patients; 52 eyes) received a placebo of Panavir® and Acyclovir ophthalmic ointment. The primary parameter of the efficiency was the percentage of patients achieving clinical recovery, i.e. signs of complete epithelialization of the cornea. Results . In group 2 (monotherapy), a significantly greater number of patients with mild conjunctival hyperemia was registered than in the combination therapy group 1 — 59.26 vs. 23.08 %, p < 0.001. In group 1, the proportion of patients without corneal syndrome at visits 3 and 4 was, respectively, 11.11 and 61.11 %, while in group 2 it was only 3.85 and 19.61 %, respectively. Conclusion . The drug Panavir® eye drops 0.004 % showed a high therapeutic efficiency in the combined treatment of herpetic keratitis, and good tolerance. It also reduced the time required for corneal epithelialization and conjunctiva normalization.
在发展中国家，眼疱疹是最常见的与感染有关的致盲原因。目的:评价药物Panavir®作为疱疹性浅表性树突状角膜炎联合治疗的疗效、安全性和耐受性。材料和方法。这项研究涉及106名年龄在18岁至65岁之间的患者，他们被分为两组。第一组(54例);54只眼)接受Panavir®和阿昔洛韦眼膏治疗，而2组(52例;52只眼)接受安慰剂Panavir®和阿昔洛韦眼膏。效率的主要参数是患者达到临床恢复的百分比，即角膜完全上皮化的迹象。结果。在第2组(单药治疗)中，轻度结膜充血的患者数量明显多于联合治疗组(59.26% vs. 23.08%， p <0.001. 第1组第3次和第4次就诊时无角膜综合征的患者比例分别为11.11%和61.11%，而第2组分别仅为3.85%和19.61%。结论。0.004%药物Panavir®滴眼液联合治疗疱疹性角膜炎疗效高，耐受性好。它还减少了角膜上皮化和结膜正常化所需的时间。
{"title":"The effectiveness of a new antiviral drug of plant origin in the form of eye drops in the complex therapy of ophthalmic herpes","authors":"E. V. Yani, T. G. Kamenskikh, E. V. Veselova, T. G. Zubkova, S. V. Stovbun, K. E. Seliverstova, V. V. Pozdnyakova, M. M. Stupakova","doi":"10.21516/2072-0076-2023-16-3-104-110","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-104-110","url":null,"abstract":"Ophthalmic herpes is the most common infection-related cause of blindness in developing countries. Purpose : to evaluate the therapeutic efficacy, safety and tolerability of the drug Panavir® used as part of a combination therapy for herpetic superficial dendritic keratitis. Materials and methods . The study involved 106 patients aged 18 to 65 years divided into two groups. Group 1 (54 patients; 54 eyes) received treatment with Panavir® and Acyclovir ophthalmic ointment, whilst Group 2 (52 patients; 52 eyes) received a placebo of Panavir® and Acyclovir ophthalmic ointment. The primary parameter of the efficiency was the percentage of patients achieving clinical recovery, i.e. signs of complete epithelialization of the cornea. Results . In group 2 (monotherapy), a significantly greater number of patients with mild conjunctival hyperemia was registered than in the combination therapy group 1 — 59.26 vs. 23.08 %, p < 0.001. In group 1, the proportion of patients without corneal syndrome at visits 3 and 4 was, respectively, 11.11 and 61.11 %, while in group 2 it was only 3.85 and 19.61 %, respectively. Conclusion . The drug Panavir® eye drops 0.004 % showed a high therapeutic efficiency in the combined treatment of herpetic keratitis, and good tolerance. It also reduced the time required for corneal epithelialization and conjunctiva normalization.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136253514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.21516/2072-0076-2023-16-3-47-53
V. V. Neroev, A. A. Bragin, O. V. Zaytseva
The importance of early detection and monitoring of retinal diseases determines the relevance of the study devoted to the diagnosis of retinal pathologies by OCT images using artificial intelligence (AI) tools.The purpose is to develop algorithms for diagnosing retinal pathologies from OCT images by machine learning methods. Material and methods . The study used a dataset (20,000 eyes), publicly available on the Internet, which contains OCT images of healthy retina (5,000 eyes) and retina affected by three different pathologies (choroid neovascularization, macular edema, multiple drusen, 15,000 eyes). The retinal pathology recognition system is based on a trained neural network VGG16 (developed by a visual geometry group of Oxford University). Results . The main result of the research is the development of an algorithm, implemented on Python, for the diagnosis of retinal diseases from OCT images based on convolutional neural network AI tool. The sensitivity and selectiveness of the neural network model during the diagnosis of retinal diseases were 97 and 98%, respectively. Conclusion . AI methods used in the retinal pathology automatic detection system developed at the Helmholtz National Medical Research Center of Eye Diseases as part of automated medical decision-making system have been shown to have high potential and efficiency. In the future, this service can be used to improve the effectiveness of early diagnosis and monitoring of retinal diseases in conditions of reduced availability of primary ophthalmological care in some of the territories of the Russian Federation, including that provided at the pre-doctoral stage.
{"title":"Diagnostics of retinal pathologies by optical coherence tomography images using artificial intelligence tools","authors":"V. V. Neroev, A. A. Bragin, O. V. Zaytseva","doi":"10.21516/2072-0076-2023-16-3-47-53","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-47-53","url":null,"abstract":"The importance of early detection and monitoring of retinal diseases determines the relevance of the study devoted to the diagnosis of retinal pathologies by OCT images using artificial intelligence (AI) tools.The purpose is to develop algorithms for diagnosing retinal pathologies from OCT images by machine learning methods. Material and methods . The study used a dataset (20,000 eyes), publicly available on the Internet, which contains OCT images of healthy retina (5,000 eyes) and retina affected by three different pathologies (choroid neovascularization, macular edema, multiple drusen, 15,000 eyes). The retinal pathology recognition system is based on a trained neural network VGG16 (developed by a visual geometry group of Oxford University). Results . The main result of the research is the development of an algorithm, implemented on Python, for the diagnosis of retinal diseases from OCT images based on convolutional neural network AI tool. The sensitivity and selectiveness of the neural network model during the diagnosis of retinal diseases were 97 and 98%, respectively. Conclusion . AI methods used in the retinal pathology automatic detection system developed at the Helmholtz National Medical Research Center of Eye Diseases as part of automated medical decision-making system have been shown to have high potential and efficiency. In the future, this service can be used to improve the effectiveness of early diagnosis and monitoring of retinal diseases in conditions of reduced availability of primary ophthalmological care in some of the territories of the Russian Federation, including that provided at the pre-doctoral stage.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136360393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.21516/2072-0076-2023-16-3-75-80
S. V. Saakyan, I. V. Tsapenko, E. B. Myakoshina, M. V. Zueva, V. I. Kotelin
To assess the role of multifocal electroretinography (mf-ERG) in preclinical diagnosis of tumor-associated distant maculopathy in small choroidal melanoma (CM) of extramacular localization. Material and methods . 35 patients (35 affected and 35 fellow eyes) with small CM of extramacular localization and 23 healthy volunteers (46 eyes) aged 59.67 ± 14.2 years were given general ophthalmological examinations and mf-ERG. Density (nV/deg2), culmination time of the P1 component and amplitude (μV) of the N1 component were measured for 5 response rings (R1–R5) at different distances from the fixation point: central hexagon R1: 2.3° (fovea zone); R2: 2.3–6.9° (parafovea); R3: 6.9–14.3° (perifovea); R4: 14.3–20.8° and R5: 20.8–29.9° (middle periphery areas of the retina). Results . Eyes affected by CM showed a decrease in the density of the P1 component in the R1 hexagon by 25.7% of the normal values (p = 0.03). The fellow eyes showed an increase in the density of the P1 component in the R2 ring (p < 0.05). The peak latency of the P1 component in the R1–R5 rings in the affected and fellow eye was found to elongate by 30–45% (p < 0.05). The amplitude of the N1 component in the central hexagon of CM-affected eyes increased by 12.96%, whilst in the R4–R5 rings it decreased by 36–45% as compared with healthy individuals (p < 0.05). The fellow eye showed supernormal values of the N1 amplitude in R1 and its suppression in R4 and R5 rings (p < 0.05). Conclusion . The mf-ERG method is useful for preclinical diagnosis of tumor-associated distant maculopathy in small CM of extramacular localization. Changes in mf-ERG of the fellow eye in patients with small CM have been documented.
{"title":"The role of multifocal electroretinography in the preclinical diagnosis of tumor-associated distant maculopathy in small melanoma of the choroid of extramacular localization","authors":"S. V. Saakyan, I. V. Tsapenko, E. B. Myakoshina, M. V. Zueva, V. I. Kotelin","doi":"10.21516/2072-0076-2023-16-3-75-80","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-75-80","url":null,"abstract":"To assess the role of multifocal electroretinography (mf-ERG) in preclinical diagnosis of tumor-associated distant maculopathy in small choroidal melanoma (CM) of extramacular localization. Material and methods . 35 patients (35 affected and 35 fellow eyes) with small CM of extramacular localization and 23 healthy volunteers (46 eyes) aged 59.67 ± 14.2 years were given general ophthalmological examinations and mf-ERG. Density (nV/deg2), culmination time of the P1 component and amplitude (μV) of the N1 component were measured for 5 response rings (R1–R5) at different distances from the fixation point: central hexagon R1: 2.3° (fovea zone); R2: 2.3–6.9° (parafovea); R3: 6.9–14.3° (perifovea); R4: 14.3–20.8° and R5: 20.8–29.9° (middle periphery areas of the retina). Results . Eyes affected by CM showed a decrease in the density of the P1 component in the R1 hexagon by 25.7% of the normal values (p = 0.03). The fellow eyes showed an increase in the density of the P1 component in the R2 ring (p < 0.05). The peak latency of the P1 component in the R1–R5 rings in the affected and fellow eye was found to elongate by 30–45% (p < 0.05). The amplitude of the N1 component in the central hexagon of CM-affected eyes increased by 12.96%, whilst in the R4–R5 rings it decreased by 36–45% as compared with healthy individuals (p < 0.05). The fellow eye showed supernormal values of the N1 amplitude in R1 and its suppression in R4 and R5 rings (p < 0.05). Conclusion . The mf-ERG method is useful for preclinical diagnosis of tumor-associated distant maculopathy in small CM of extramacular localization. Changes in mf-ERG of the fellow eye in patients with small CM have been documented.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"228 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136360394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.21516/2072-0076-2023-16-3-60-68
V. V. Neroev, S. Yu. Petrov, A. N. Zhuravleva, O. M. Filippova, O. M. Kalinina, L. V. Yakubova, S. M. Kosakyan, L. V. Vasilenkova
Purpose : to determine the efficacy and safety of fixed latanoprost/dorzolamide combination Dorzoprost in hypotensive treatment of primary open-angle glaucoma (POAG) patients previously treated with latanoprost. Material and methods . An observational study included 30 patients (37 eyes) with moderate and advanced POAG who had uncompensated elevated IOP receiving latanoprost monotherapy. During the screening visit, latanoprost was switched to Dorzoprost instilled once in the evening. The targets were IOP, visual acuity, MD and PSD perimetry indices, retinal nerve fiber layer thickness, minimum width of the neuroretinal rim, macula retinal nerve fiber layer thickness, and adverse events. The observation period lasted 12 weeks. IOP was measured at weeks 4 and 12. Results . After 4 weeks, a statistically significant decrease in IOP was noted, which remained stable at 12 weeks. The average additional IOP decrease of those treated with Dorzoprost was 17%. Statistically insignificant positive changes were registered in visual acuity, static perimetry and optical coherence tomography. By the end of the observation period, 6 cases revealed a decrease in the degree of conjunctival hyperemia, while all dry eye syndrome cases (5 patients) showed a decrease in the severity of the signs of the syndrome. Conclusion . Dorzoprost has a significant additive hypotensive effect and a favorable safety profile.
{"title":"Efficiency and safety of the fixed latanoprost/ dorzolamide combination in open-angle glaucoma hypotensive treatment","authors":"V. V. Neroev, S. Yu. Petrov, A. N. Zhuravleva, O. M. Filippova, O. M. Kalinina, L. V. Yakubova, S. M. Kosakyan, L. V. Vasilenkova","doi":"10.21516/2072-0076-2023-16-3-60-68","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-60-68","url":null,"abstract":"Purpose : to determine the efficacy and safety of fixed latanoprost/dorzolamide combination Dorzoprost in hypotensive treatment of primary open-angle glaucoma (POAG) patients previously treated with latanoprost. Material and methods . An observational study included 30 patients (37 eyes) with moderate and advanced POAG who had uncompensated elevated IOP receiving latanoprost monotherapy. During the screening visit, latanoprost was switched to Dorzoprost instilled once in the evening. The targets were IOP, visual acuity, MD and PSD perimetry indices, retinal nerve fiber layer thickness, minimum width of the neuroretinal rim, macula retinal nerve fiber layer thickness, and adverse events. The observation period lasted 12 weeks. IOP was measured at weeks 4 and 12. Results . After 4 weeks, a statistically significant decrease in IOP was noted, which remained stable at 12 weeks. The average additional IOP decrease of those treated with Dorzoprost was 17%. Statistically insignificant positive changes were registered in visual acuity, static perimetry and optical coherence tomography. By the end of the observation period, 6 cases revealed a decrease in the degree of conjunctival hyperemia, while all dry eye syndrome cases (5 patients) showed a decrease in the severity of the signs of the syndrome. Conclusion . Dorzoprost has a significant additive hypotensive effect and a favorable safety profile.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136360253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.21516/2072-0076-2023-16-3-69-74
O. G. Oganesyan, P. M. Ashikova, A. V. Ivanova, K. B. Letnikova, C. O. Oganesyan, P. V. Makarov
Late complications of radial keratotomy (RK), are as a rule caused by a change in the biomechanical properties of the cornea. Purpose : to study the long-term stabilizing effect of the Bowman’s layer (BL) transplantation after RK. Material and methods . In a limited, prospective, monocentric pilot study we operated 2 male patients (2 eyes) aged 60 and 55. The radial incisions had been performed 34 and 38 years ago. The indications for surgery were progressive biomechanical instability of the cornea and functional refractive visual fluctuations. Within 12 months after the operation, complications, corrected visual acuity, keratometric parameters, biomicroscopic transparency of the cornea, and patient satisfaction were assessed. Results. No complications were noted during the follow-up period, the cornea and graft retained transparency. The average thickness of the BS graft was 20±2.1 µm. The average visual acuity corrected by contact lenses increased from 0.4±0.3 to 0.65±0.1, the average indicator of keratometric astigmatism changed from 1.9±1.6 to 3.0 D, these indicators remained after 6, 9 and 12 months, which indicates that biomechanical stability of the cornea was achieved and that the refractive-visual fluctuations are absent. Conclusion . In late term RK complications, BS transplantation partially restores the normal anatomy of the anterior surface of the cornea and ensures its biomechanical stability during a 12-month follow-up period. For the conclusions to be maximally objective, more clinical cases should be studied within a longer observation period.
{"title":"Transplantation of the Bowman’s layer in cases of biomechanical instability of the cornea after radial keratotomy","authors":"O. G. Oganesyan, P. M. Ashikova, A. V. Ivanova, K. B. Letnikova, C. O. Oganesyan, P. V. Makarov","doi":"10.21516/2072-0076-2023-16-3-69-74","DOIUrl":"https://doi.org/10.21516/2072-0076-2023-16-3-69-74","url":null,"abstract":"Late complications of radial keratotomy (RK), are as a rule caused by a change in the biomechanical properties of the cornea. Purpose : to study the long-term stabilizing effect of the Bowman’s layer (BL) transplantation after RK. Material and methods . In a limited, prospective, monocentric pilot study we operated 2 male patients (2 eyes) aged 60 and 55. The radial incisions had been performed 34 and 38 years ago. The indications for surgery were progressive biomechanical instability of the cornea and functional refractive visual fluctuations. Within 12 months after the operation, complications, corrected visual acuity, keratometric parameters, biomicroscopic transparency of the cornea, and patient satisfaction were assessed. Results. No complications were noted during the follow-up period, the cornea and graft retained transparency. The average thickness of the BS graft was 20±2.1 µm. The average visual acuity corrected by contact lenses increased from 0.4±0.3 to 0.65±0.1, the average indicator of keratometric astigmatism changed from 1.9±1.6 to 3.0 D, these indicators remained after 6, 9 and 12 months, which indicates that biomechanical stability of the cornea was achieved and that the refractive-visual fluctuations are absent. Conclusion . In late term RK complications, BS transplantation partially restores the normal anatomy of the anterior surface of the cornea and ensures its biomechanical stability during a 12-month follow-up period. For the conclusions to be maximally objective, more clinical cases should be studied within a longer observation period.","PeriodicalId":36080,"journal":{"name":"Rossiiskii Oftal''mologicheskii Zhurnal","volume":"262 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136360392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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