Pub Date : 2024-04-26DOI: 10.1016/j.xinn.2024.100630
Xiuqi You, Ximin Chen, Yi Jiang, Huan Chen, Juan Liu, Zhen Wu, Weiling Sun, Jinren Ni
Photosynthetic carbon fixation by cyanobacteria plays a pivotal role in the global carbon cycle but is threatened by environmental pollutants. To date, the impact of quinones, with electron shuttling properties, on cyanobacterial photosynthesis is unknown. Here, we present the first study investigating the effects of an emerging quinone pollutant, i.e., 6PPD-Q (N-(1,3-dimethylbutyl)-N′-phenyl--phenylenediamine-quinone), on the cyanobacterium sp. over a 400-generation exposure period. sp. exhibited distinct sequential phases, including hormesis, toxicity, and eventual recovery, throughout this exposure. Extensive evidence, including results of thylakoid membrane morphological and photosynthetic responses, carbon fixation rate, and key gene/protein analyses, strongly indicates that 6PPD-Q is a potent disruptor of photosynthesis. 6PPD-Q accepts photosynthetic electrons at the Q site in photosystem II (PSII) and the A site in PSI, leading to a sustained decrease in the carbon fixation of cyanobacteria after an ephemeral increase. This work revealed the specific mechanism by which 6PPD-Q interferes with photosynthetic carbon fixation in cyanobacteria, which is highly important for the global carbon cycle.
{"title":"6PPD-quinone affects the photosynthetic carbon fixation in cyanobacteria by extracting photosynthetic electrons","authors":"Xiuqi You, Ximin Chen, Yi Jiang, Huan Chen, Juan Liu, Zhen Wu, Weiling Sun, Jinren Ni","doi":"10.1016/j.xinn.2024.100630","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100630","url":null,"abstract":"Photosynthetic carbon fixation by cyanobacteria plays a pivotal role in the global carbon cycle but is threatened by environmental pollutants. To date, the impact of quinones, with electron shuttling properties, on cyanobacterial photosynthesis is unknown. Here, we present the first study investigating the effects of an emerging quinone pollutant, i.e., 6PPD-Q (N-(1,3-dimethylbutyl)-N′-phenyl--phenylenediamine-quinone), on the cyanobacterium sp. over a 400-generation exposure period. sp. exhibited distinct sequential phases, including hormesis, toxicity, and eventual recovery, throughout this exposure. Extensive evidence, including results of thylakoid membrane morphological and photosynthetic responses, carbon fixation rate, and key gene/protein analyses, strongly indicates that 6PPD-Q is a potent disruptor of photosynthesis. 6PPD-Q accepts photosynthetic electrons at the Q site in photosystem II (PSII) and the A site in PSI, leading to a sustained decrease in the carbon fixation of cyanobacteria after an ephemeral increase. This work revealed the specific mechanism by which 6PPD-Q interferes with photosynthetic carbon fixation in cyanobacteria, which is highly important for the global carbon cycle.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"61 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140882784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-05DOI: 10.1016/j.xinn.2024.100621
Ziyan Chen, Xin Liu, Zixi Jiang, Huayi Wu, Tao Yang, Lanyuan Peng, Lisha Wu, Zhongling Luo, Mi Zhang, Juan Su, Yan Tang, Jinmao Li, Yang Xie, Han Shan, Qibo Lin, Xiuli Wang, Xiang Chen, Hanmin Peng, Shuang Zhao, Zeyu Chen
With over a million cases detected each year, skin disease is a global public health problem that diminishes the quality of life due to its difficulty to eradicate, propensity for recurrence, and potential for post-treatment scarring. Photodynamic therapy (PDT) is a treatment with minimal invasiveness or scarring and few side effects, making it well tolerated by patients. However, this treatment requires further research and development to improve its effective clinical use. Here, a piezoelectric-driven microneedle (PDMN) platform that achieves high efficiency, safety, and non-invasiveness for enhanced PDT is proposed. This platform induces deep tissue cavitation, increasing the level of protoporphyrin IX and significantly enhancing drug penetration. A clinical trial involving 25 patients with skin disease was conducted to investigate the timeliness and efficacy of PDMN-assisted PDT (PDMN-PDT). Our findings suggested that PDMN-PDT boosted treatment effectiveness and reduced the required incubation time and drug concentration by 25% and 50%, respectively, without any anesthesia compared to traditional PDT. These findings suggest that PDMN-PDT is a safe and minimally invasive approach for skin disease treatment, which may improve the therapeutic efficacy of topical medications and enable translation for future clinical applications.
{"title":"A piezoelectric-driven microneedle platform for skin disease therapy","authors":"Ziyan Chen, Xin Liu, Zixi Jiang, Huayi Wu, Tao Yang, Lanyuan Peng, Lisha Wu, Zhongling Luo, Mi Zhang, Juan Su, Yan Tang, Jinmao Li, Yang Xie, Han Shan, Qibo Lin, Xiuli Wang, Xiang Chen, Hanmin Peng, Shuang Zhao, Zeyu Chen","doi":"10.1016/j.xinn.2024.100621","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100621","url":null,"abstract":"With over a million cases detected each year, skin disease is a global public health problem that diminishes the quality of life due to its difficulty to eradicate, propensity for recurrence, and potential for post-treatment scarring. Photodynamic therapy (PDT) is a treatment with minimal invasiveness or scarring and few side effects, making it well tolerated by patients. However, this treatment requires further research and development to improve its effective clinical use. Here, a piezoelectric-driven microneedle (PDMN) platform that achieves high efficiency, safety, and non-invasiveness for enhanced PDT is proposed. This platform induces deep tissue cavitation, increasing the level of protoporphyrin IX and significantly enhancing drug penetration. A clinical trial involving 25 patients with skin disease was conducted to investigate the timeliness and efficacy of PDMN-assisted PDT (PDMN-PDT). Our findings suggested that PDMN-PDT boosted treatment effectiveness and reduced the required incubation time and drug concentration by 25% and 50%, respectively, without any anesthesia compared to traditional PDT. These findings suggest that PDMN-PDT is a safe and minimally invasive approach for skin disease treatment, which may improve the therapeutic efficacy of topical medications and enable translation for future clinical applications.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"50 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.1016/j.xinn.2024.100622
Yi-Da Tang, Er-Dan Dong, Wen Gao
{"title":"LLMs in medicine: The need for advanced evaluation systems for disruptive technologies","authors":"Yi-Da Tang, Er-Dan Dong, Wen Gao","doi":"10.1016/j.xinn.2024.100622","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100622","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"18 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.1016/j.xinn.2024.100623
Guo-Bo Chen, Siyang Liu, Lei Zhang, Tao Huang, Xiaohua Tang, Yixue Li, Changqing Zeng
{"title":"Building and sharing medical cohorts for research","authors":"Guo-Bo Chen, Siyang Liu, Lei Zhang, Tao Huang, Xiaohua Tang, Yixue Li, Changqing Zeng","doi":"10.1016/j.xinn.2024.100623","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100623","url":null,"abstract":"","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"17 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the last decade, organoid research has entered a golden era, signifying a pivotal shift in the biomedical landscape. The year 2023 marked a milestone with the publication of thousands of papers in this arena, reflecting exponential growth. However, amid this burgeoning expansion, a comprehensive and accurate overview of the field has been conspicuously absent. Our review is intended to bridge this gap, providing a panoramic view of the rapidly evolving organoid landscape. We meticulously analyze the organoid field from eight distinctive vantage points, harnessing our rich experience in academic research, industrial application, and clinical practice. We present a deep exploration of the advances in organoid technology, underpinned by our long-standing involvement in this arena. Our narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors, including oncology, toxicology, and drug development. We delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine, enhancing high-throughput drug screening, and constructing physiologically pertinent disease models. Our comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid technology. We spotlight technological innovations, methodological evolution, and the broadening spectrum of applications, emphasizing the revolutionary influence of organoids in personalized medicine, oncology, drug discovery, and other fields. Looking ahead, we cautiously anticipate future developments in the field of organoid research, especially its potential implications for personalized patient care, new avenues of drug discovery, and clinical research. We trust that our comprehensive review will be an asset for researchers, clinicians, and patients with keen interest in personalized medical strategies. We offer a broad view of the present and prospective capabilities of organoid technology, encompassing a wide range of current and future applications. In summary, in this review we attempt a comprehensive exploration of the organoid field. We offer reflections, summaries, and projections that might be useful for current researchers and clinicians, and we hope to contribute to shaping the evolving trajectory of this dynamic and rapidly advancing field.
{"title":"Landscape of human organoids: Ideal model in clinics and research","authors":"Xinxin Han, Chunhui Cai, Wei Deng, Yanghua Shi, Lanyang Li, Chen Wang, Jian Zhang, Mingjie Rong, Jiping Liu, Bangjiang Fang, Hua He, Xiling Liu, Chuxia Deng, Xiao He, Xin Cao","doi":"10.1016/j.xinn.2024.100620","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100620","url":null,"abstract":"In the last decade, organoid research has entered a golden era, signifying a pivotal shift in the biomedical landscape. The year 2023 marked a milestone with the publication of thousands of papers in this arena, reflecting exponential growth. However, amid this burgeoning expansion, a comprehensive and accurate overview of the field has been conspicuously absent. Our review is intended to bridge this gap, providing a panoramic view of the rapidly evolving organoid landscape. We meticulously analyze the organoid field from eight distinctive vantage points, harnessing our rich experience in academic research, industrial application, and clinical practice. We present a deep exploration of the advances in organoid technology, underpinned by our long-standing involvement in this arena. Our narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors, including oncology, toxicology, and drug development. We delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine, enhancing high-throughput drug screening, and constructing physiologically pertinent disease models. Our comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid technology. We spotlight technological innovations, methodological evolution, and the broadening spectrum of applications, emphasizing the revolutionary influence of organoids in personalized medicine, oncology, drug discovery, and other fields. Looking ahead, we cautiously anticipate future developments in the field of organoid research, especially its potential implications for personalized patient care, new avenues of drug discovery, and clinical research. We trust that our comprehensive review will be an asset for researchers, clinicians, and patients with keen interest in personalized medical strategies. We offer a broad view of the present and prospective capabilities of organoid technology, encompassing a wide range of current and future applications. In summary, in this review we attempt a comprehensive exploration of the organoid field. We offer reflections, summaries, and projections that might be useful for current researchers and clinicians, and we hope to contribute to shaping the evolving trajectory of this dynamic and rapidly advancing field.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"21 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-13DOI: 10.1016/j.xinn.2024.100612
Fang Wang, Leilei Xiang, Kelvin Sze-Yin Leung, Martin Elsner, Ying Zhang, Yuming Guo, Bo Pan, Hongwen Sun, Taicheng An, Guangguo Ying, Bryan W. Brooks, Deyi Hou, Damian E. Helbling, Jianqiang Sun, Hao Qiu, Timothy M. Vogel, Wei Zhang, Yanzheng Gao, Myrna J. Simpson, Yi Luo, Scott X. Chang, Guanyong Su, Bryan M. Wong, Tzung-May Fu, Dong Zhu, Karl J. Jobst, Chengjun Ge, Frederic Coulon, Jean Damascene Harindintwali, Xiankui Zeng, Haijun Wang, Yuhao Fu, Zhong Wei, Rainer Lohmann, Changer Chen, Yang Song, Concepcion Sanchez-Cid, Yu Wang, Ali El-Naggar, Yiming Yao, Yanran Huang, Japhet Cheuk-Fung Law, Chenggang Gu, Huizhong Shen, Yanpeng Gao, Chao Qin, Hao Li, Tong Zhang, Natàlia Corcoll, Min Liu, Daniel S. Alessi, Hui Li, Kristian K. Brandt, Yolanda Pico, Cheng Gu, Jianhua Guo, Jianqiang Su, Philippe Corvini, Mao Ye, Teresa Rocha-Santos, Huan He, Yi Yang, Meiping Tong, Weina Zhang, Fidèle Suanon, Ferdi Brahushi, Zhenyu Wang, Syed A. Hashsham, Marko Virta, Qingbin Yuan, Gaofei Jiang, Louis A. Tremblay, Qingwei Bu, Jichun Wu, Willie Peijnenburg, Edward Topp, Xinde Cao, Xin Jiang, Minghui Zheng, Taolin Zhang, Yongming Luo, Lizhong Zhu, Xiangdong Li, Damià Barceló, Jianmin Chen, Baoshan Xing, Wulf Amelung, Zongwei Cai, Ravi Naidu, Qirong Shen, Janusz Pawliszyn, Yong-guan Zhu, Andreas Schaeffer, Matthias C. Rillig, Fengchang Wu, Gang Yu, James M. Tiedje
Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both human and ecosystem health. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the establishment of the UN’s Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition towards sustainable pollution management practices to safeguard our planet for future generations.
{"title":"Emerging Contaminants: A One Health Perspective","authors":"Fang Wang, Leilei Xiang, Kelvin Sze-Yin Leung, Martin Elsner, Ying Zhang, Yuming Guo, Bo Pan, Hongwen Sun, Taicheng An, Guangguo Ying, Bryan W. Brooks, Deyi Hou, Damian E. Helbling, Jianqiang Sun, Hao Qiu, Timothy M. Vogel, Wei Zhang, Yanzheng Gao, Myrna J. Simpson, Yi Luo, Scott X. Chang, Guanyong Su, Bryan M. Wong, Tzung-May Fu, Dong Zhu, Karl J. Jobst, Chengjun Ge, Frederic Coulon, Jean Damascene Harindintwali, Xiankui Zeng, Haijun Wang, Yuhao Fu, Zhong Wei, Rainer Lohmann, Changer Chen, Yang Song, Concepcion Sanchez-Cid, Yu Wang, Ali El-Naggar, Yiming Yao, Yanran Huang, Japhet Cheuk-Fung Law, Chenggang Gu, Huizhong Shen, Yanpeng Gao, Chao Qin, Hao Li, Tong Zhang, Natàlia Corcoll, Min Liu, Daniel S. Alessi, Hui Li, Kristian K. Brandt, Yolanda Pico, Cheng Gu, Jianhua Guo, Jianqiang Su, Philippe Corvini, Mao Ye, Teresa Rocha-Santos, Huan He, Yi Yang, Meiping Tong, Weina Zhang, Fidèle Suanon, Ferdi Brahushi, Zhenyu Wang, Syed A. Hashsham, Marko Virta, Qingbin Yuan, Gaofei Jiang, Louis A. Tremblay, Qingwei Bu, Jichun Wu, Willie Peijnenburg, Edward Topp, Xinde Cao, Xin Jiang, Minghui Zheng, Taolin Zhang, Yongming Luo, Lizhong Zhu, Xiangdong Li, Damià Barceló, Jianmin Chen, Baoshan Xing, Wulf Amelung, Zongwei Cai, Ravi Naidu, Qirong Shen, Janusz Pawliszyn, Yong-guan Zhu, Andreas Schaeffer, Matthias C. Rillig, Fengchang Wu, Gang Yu, James M. Tiedje","doi":"10.1016/j.xinn.2024.100612","DOIUrl":"https://doi.org/10.1016/j.xinn.2024.100612","url":null,"abstract":"Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both human and ecosystem health. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the establishment of the UN’s Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition towards sustainable pollution management practices to safeguard our planet for future generations.","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":"152 1","pages":""},"PeriodicalIF":32.1,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140170763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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