The Acute Respiratory Distress Syndrome (ARDS) is one of the major heterogeneous clinical manifestations of severe respiratory failure developing in response to pathogenetic mechanisms and several inflammatory insults. The translocation of gut microbiota has a crucial impact on the pathogenesis of ARDS. Hence, a deeper understanding of the interplay of the gut microbiota would allow shedding valuable insights into both the pathogenesis of ARDS and the development of effective therapeutic interventions. Moreover, the modulation of gut-lung axis could also play a pivotal role in minimizing the lung dysbiosis with gut microbiota. There is little question that greater study of the gut-lung axis in critically ill patients is required to establish causal links between the shifted microbiota, infections, inflammation, and acute lung damage. It is worth mentioning that the lack of effective preventative measures is one of the main reasons for the increased mortality rate of 30-40% in ARDS patients. Some antibiotics and nanosized drugs showed positive results in ARDS management to some extent in pre-clinical or even first stages of clinical trials but large-scale results had been controversial. However, Sphingosine-1-Phosphate (S1P) showed hopeful results in ARDS patients by facilitating both systemic and endothelial integrity. Numerous investigations have shown the immunological connection between the gastrointestinal tract and the respiratory system. As the SphKs /S1P /S1PL metabolic pathway is associated with a wide variety of human illnesses (including respiratory diseases), it should come as no surprise that influencing intracellular S1P levels would have therapeutic promise in reducing the severity of lung diseases like ARDS.
{"title":"Association of gut microbiota in the pathogenesis of acute respiratory distress syndrome and possible pharmacotherapy by sphingosine-1-phosphate","authors":"Tasbir Amin, Fahd Zahed","doi":"10.5455/jabet.2023.d151","DOIUrl":"https://doi.org/10.5455/jabet.2023.d151","url":null,"abstract":"The Acute Respiratory Distress Syndrome (ARDS) is one of the major heterogeneous clinical manifestations of severe respiratory failure developing in response to pathogenetic mechanisms and several inflammatory insults. The translocation of gut microbiota has a crucial impact on the pathogenesis of ARDS. Hence, a deeper understanding of the interplay of the gut microbiota would allow shedding valuable insights into both the pathogenesis of ARDS and the development of effective therapeutic interventions. Moreover, the modulation of gut-lung axis could also play a pivotal role in minimizing the lung dysbiosis with gut microbiota. There is little question that greater study of the gut-lung axis in critically ill patients is required to establish causal links between the shifted microbiota, infections, inflammation, and acute lung damage. It is worth mentioning that the lack of effective preventative measures is one of the main reasons for the increased mortality rate of 30-40% in ARDS patients. Some antibiotics and nanosized drugs showed positive results in ARDS management to some extent in pre-clinical or even first stages of clinical trials but large-scale results had been controversial. However, Sphingosine-1-Phosphate (S1P) showed hopeful results in ARDS patients by facilitating both systemic and endothelial integrity. Numerous investigations have shown the immunological connection between the gastrointestinal tract and the respiratory system. As the SphKs /S1P /S1PL metabolic pathway is associated with a wide variety of human illnesses (including respiratory diseases), it should come as no surprise that influencing intracellular S1P levels would have therapeutic promise in reducing the severity of lung diseases like ARDS.","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Many countries have been seen two wave patterns of reported cases of coronavirus diseases. Still, a limited number of studies compared the epidemiological attributes of the first wave and second wave of coronavirus diseases 2019 (COVID-19) outbreak. This study was carried out to compare the epidemics of two waves in Bangladesh. This observational study data of suspected cases was collected from June 2020 to April 2021 from a local authorized diagnostic center. From June 27, 2020, to July 27, 2020, was considered as the first wave and from March 20, 2021, to April 20, 2021, was considered a second wave. This period was determined because of observing the highest number of positive cases during that period. Out of 21,359 cases, including 2429 (11.37%) individuals in the first wave and 4989 (23.36%) individuals in the second wave had RT-PCR test for disease confirmation. Among them, 315 people in the first wave and 630 in the second wave were positive for SARS-CoV-2 RNA. Male were more vernalized to the positive case, including 204 (64.8%) and 421 (66.8%) during the first and second waves, respectively. People under 41 found 56.2% positive cases during the first wave while it was 65.6% in the second wave. We also found 128 positive cases among international travelers. In conclusion, a large extent of different epidemiological attributes was found in the second wave compared to the first wave of the outbreaks.
{"title":"Epidemiological comparison of the first and second wave of COVID-19 Pandemic in Dhaka, Bangladesh: A cross-sectional study among suspected cases.","authors":"Islam, Israk, Jahan","doi":"10.5455/jabet.2022.d101","DOIUrl":"https://doi.org/10.5455/jabet.2022.d101","url":null,"abstract":"Many countries have been seen two wave patterns of reported cases of coronavirus diseases. Still, a limited number of studies compared the epidemiological attributes of the first wave and second wave of coronavirus diseases 2019 (COVID-19) outbreak. This study was carried out to compare the epidemics of two waves in Bangladesh. This observational study data of suspected cases was collected from June 2020 to April 2021 from a local authorized diagnostic center. From June 27, 2020, to July 27, 2020, was considered as the first wave and from March 20, 2021, to April 20, 2021, was considered a second wave. This period was determined because of observing the highest number of positive cases during that period. Out of 21,359 cases, including 2429 (11.37%) individuals in the first wave and 4989 (23.36%) individuals in the second wave had RT-PCR test for disease confirmation. Among them, 315 people in the first wave and 630 in the second wave were positive for SARS-CoV-2 RNA. Male were more vernalized to the positive case, including 204 (64.8%) and 421 (66.8%) during the first and second waves, respectively. People under 41 found 56.2% positive cases during the first wave while it was 65.6% in the second wave. We also found 128 positive cases among international travelers. In conclusion, a large extent of different epidemiological attributes was found in the second wave compared to the first wave of the outbreaks.","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70795990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of process validation and equipment qualification in production of bio-therapeutics","authors":"G. Ghosh, R. Bodroth, Basabjit Dutta","doi":"10.5455/jabet.2022.d105","DOIUrl":"https://doi.org/10.5455/jabet.2022.d105","url":null,"abstract":"","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70796047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Sultana, M. Pervin, S. Sultana, Moutuza Mostaree, S. Belal, Mohammad Khan
{"title":"Pathological investigation and molecular detection of bacterial zoonotic diseases of slaughtered cattle in Bangladesh","authors":"N. Sultana, M. Pervin, S. Sultana, Moutuza Mostaree, S. Belal, Mohammad Khan","doi":"10.5455/jabet.2022.d113","DOIUrl":"https://doi.org/10.5455/jabet.2022.d113","url":null,"abstract":"","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70796181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Azad, Sharmin Ahmed, P. Biswas, M. Mia, M. Farjana, F. Arshe, S. Mily, A. Ankhi, M. Shaikat, Sabeeha Sultana, Kashfia Mawa, Z. Naim, M. Rahman, Bonglee Kim
{"title":"Quantitative analysis of the factors influencing IDA and TSH downregulation in correlation to the fluctuation of activated vitamin D3 in women","authors":"S. Azad, Sharmin Ahmed, P. Biswas, M. Mia, M. Farjana, F. Arshe, S. Mily, A. Ankhi, M. Shaikat, Sabeeha Sultana, Kashfia Mawa, Z. Naim, M. Rahman, Bonglee Kim","doi":"10.5455/jabet.2022.d118","DOIUrl":"https://doi.org/10.5455/jabet.2022.d118","url":null,"abstract":"","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70795961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Reza, Mohamad Tarik, R. Hasib, M. Alam, Md Mamunur Rahman, Mohammad Jamal
{"title":"HtrA1 and HtrA2 expression differentially modulate the clinical prognosis of cancer: a multi-omics analysis using bioinformatics approaches.","authors":"A. Reza, Mohamad Tarik, R. Hasib, M. Alam, Md Mamunur Rahman, Mohammad Jamal","doi":"10.5455/jabet.2022.d121","DOIUrl":"https://doi.org/10.5455/jabet.2022.d121","url":null,"abstract":"","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70796025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Kiti, C. Kibiti, C. Munga, J. Odalo, Paul M. Guyo, S. Mwamburi
Abstract The advent of resistant pathogenic bacteria and fungi across the globe is threatening the efficacy of antibiotic drugs. Thus, microbial infections are becoming a threat to life. Endophytic fungi remain a viable source of secondary metabolites with unique spectra of biological activities. This study isolated and characterized endophytic fungi from selected mangrove species of coastal Kenya and further ascertained their activities. A total of 18 fungal endophytes selected from mangrove species were investigated for antimicrobial activity against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. Potato dextrose agar and potato dextrose broth were used for isolation, purification, and fermentation at 28oC for 7–15 days. Extraction of fungal metabolites was achieved using ethyl acetate (1:1 v/v) and ethyl acetate in 10% methanol (9:1 v/v). Solvents were recovered in a fume hood and extracts were dissolved in 1 ml of dimethyl sulfoxide. Molecular characterization completely identified 9 species, namely: Aspergillus flavus, Aspergillus niger, Aspergillus tubingensis, Aspergillus oryzae, Rhizophora nomius, Aspergillus awamori, Aspergillus aculeatus, Aspergillus bravionivious, and Aspergillus welwitchiae. The minimum inhibitory concentration of ethyl acetate crude extracts of the most active fungal isolate, A. flavus (MT447532.1), was 0.91 0.05 mg/ml and 0.82 0.052 mg/ml against S. aureus and E. coli, respectively. Results showed that some crude extracts of mangrove fungal endophytes from coastal Kenya are effective against bacteria, hence a promising source of novel organic natural metabolites with a possible wide range of biological activities.
{"title":"Molecular characterization and antibacterial activities of mangrove fungal endophytes from coastal Kenya","authors":"H. Kiti, C. Kibiti, C. Munga, J. Odalo, Paul M. Guyo, S. Mwamburi","doi":"10.5455/jabet.2022.d144","DOIUrl":"https://doi.org/10.5455/jabet.2022.d144","url":null,"abstract":"Abstract The advent of resistant pathogenic bacteria and fungi across the globe is threatening the efficacy of antibiotic drugs. Thus, microbial infections are becoming a threat to life. Endophytic fungi remain a viable source of secondary metabolites with unique spectra of biological activities. This study isolated and characterized endophytic fungi from selected mangrove species of coastal Kenya and further ascertained their activities. A total of 18 fungal endophytes selected from mangrove species were investigated for antimicrobial activity against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. Potato dextrose agar and potato dextrose broth were used for isolation, purification, and fermentation at 28oC for 7–15 days. Extraction of fungal metabolites was achieved using ethyl acetate (1:1 v/v) and ethyl acetate in 10% methanol (9:1 v/v). Solvents were recovered in a fume hood and extracts were dissolved in 1 ml of dimethyl sulfoxide. Molecular characterization completely identified 9 species, namely: Aspergillus flavus, Aspergillus niger, Aspergillus tubingensis, Aspergillus oryzae, Rhizophora nomius, Aspergillus awamori, Aspergillus aculeatus, Aspergillus bravionivious, and Aspergillus welwitchiae. The minimum inhibitory concentration of ethyl acetate crude extracts of the most active fungal isolate, A. flavus (MT447532.1), was 0.91 0.05 mg/ml and 0.82 0.052 mg/ml against S. aureus and E. coli, respectively. Results showed that some crude extracts of mangrove fungal endophytes from coastal Kenya are effective against bacteria, hence a promising source of novel organic natural metabolites with a possible wide range of biological activities.","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70796741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasir Mawlah, M. Naji, Mustafa Jawad Al-Imari, H. Abdulabbas
{"title":"Micro-RNA evaluation, specification, and stabilization study in mixed/non-mixed body fluids as a specific molecular marker","authors":"Yasir Mawlah, M. Naji, Mustafa Jawad Al-Imari, H. Abdulabbas","doi":"10.5455/jabet.2022.d120","DOIUrl":"https://doi.org/10.5455/jabet.2022.d120","url":null,"abstract":"","PeriodicalId":36275,"journal":{"name":"Journal of Advanced Biotechnology and Experimental Therapeutics","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70796014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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