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Human Skeletal Muscle Fiber Type Switching Revisited 人类骨骼肌纤维类型转换再研究
Q4 Health Professions Pub Date : 2023-11-30 DOI: 10.15857/ksep.2023.00507
Takayuki Akimoto
Skeletal muscles are composed of several fiber types that differ in their structure, molecular composition, metabolic activity, and functional properties. The four major myosin heavy chain (MyHC) isoforms, slow-twitch oxidative (type I), fast-twitch oxidative (type IIa), fast-twitch oxidative glycolytic (type IId/x), and fast-twitch glycolytic (type IIb), are hetero-geneously distributed in the skeletal muscles of mammals, and are useful markers for the muscle fiber types [1]. In humans, MyHC IIb is not detectable in skeletal muscles, but MYH4 , the gene encoding this protein, is present in our genome. Muscle performance is, at least partly, dictated by the composition of muscle fiber types, and precise understanding of the fiber type has attracted much attention from sports scientists. In addition, increased interest in the role of skeletal muscle in metabolic diseases has extended the awareness of muscle fiber types to a wide audience in clinical medicine [2].
骨骼肌由几种纤维类型组成,它们的结构、分子组成、代谢活动和功能特性各不相同。四种主要的肌球蛋白重链(MyHC)异构体,即慢肌腱氧化型(I型)、快肌腱氧化型(IIa型)、快肌腱氧化糖酵解型(IId/x型)和快肌腱糖酵解型(IIb型),在哺乳动物的骨骼肌中呈异基因分布,是肌肉纤维类型的有用标记[1]。在人类的骨骼肌中检测不到 MyHC IIb,但我们的基因组中存在编码这种蛋白质的基因 MYH4。肌肉的表现至少部分是由肌肉纤维类型的组成决定的,对肌肉纤维类型的精确了解已引起运动科学家的极大关注。此外,由于人们对骨骼肌在代谢性疾病中的作用越来越感兴趣,临床医学领域的广大受众也开始认识到肌肉纤维类型的重要性[2]。
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引用次数: 0
Effects of an Intervention Program on Lumber Muscle Function in Non-Specific Chronic Low Back Pain 非特异性慢性腰痛干预方案对腰肌功能的影响
Q4 Health Professions Pub Date : 2023-11-01 DOI: 10.15857/ksep.2023.00290
Dong-Jin Kim, Seung-Taek Lim, Ji-Hoon Cho
PURPOSE: This study compared the effects of different intervention programs of resistance exercise, stretching
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引用次数: 0
Effects of an Intervention Program on Lumber Muscle Function in Non-Specific Chronic Low Back Pain 非特异性慢性腰痛干预方案对腰肌功能的影响
Q4 Health Professions Pub Date : 2023-11-01 DOI: 10.15857/ksep.2023.00437
Dong-Jin Kim, Seung-Taek Lim, Ji-Hoon Cho
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引用次数: 0
Different Effects of Single-leg Stance Exercise and Bridging Exercise with Core Stability Exercise on Older Adults Balance 单腿站立运动与核心稳定性桥接运动对老年人平衡的不同影响
Q4 Health Professions Pub Date : 2023-08-31 DOI: 10.15857/ksep.2023.00206
Brissa Isabel Salsabila, Farid Rahman, Yenny Lindoyo
PURPOSE: Older adults experience a degenerative process that causes several health problems such as an increased risk of falling due to poor balance. However, to reduce the risk of falling exercise is used as an early intervention. The study aimed to understand the differences in the effect of single-leg stance exercises and bridging exercises with core stability exercises on increasing balance in older adults.METHODS: A quasi-experimental study was conducted at the Salus Medica Physical Medicine and Rehabilitation Clinic using a sample of 30 individuals divided into two groups. The interventions were conducted twice weekly for one month. The evaluation included first, middle, and final evaluations using the Berg Balance Scale. Moreover, the statistical test was used to determine the effect of intergroup administration on increasing the balance of older adults, whereas the independent t-test was used to determine the effects of intergroup administration on increasing balance among older adults.RESULTS: The results of the repeated-measures analysis of variance revealed that the p-value assumed sphericity in both groups (p=.000), which implies that the two groups improved the balance of the older adults. The independent t-test identified that the p-value equal variances were assumed (p=.572), which indicated no difference in the effect between the two groups in increasing the balance of older adults.CONCLUSIONS: No significant difference between single-leg stance exercises with core stability exercises and bridging exercises with core stability exercises in improving balance among older adults was observed.
目的:老年人经历退行性过程,导致一些健康问题,如由于平衡不良而增加跌倒的风险。然而,为了减少跌倒的风险,运动被用作早期干预。该研究旨在了解单腿站立练习和桥接练习与核心稳定性练习在提高老年人平衡方面的效果差异。方法:在Salus Medica物理医学和康复诊所进行准实验研究,将30名受试者分为两组。干预每周进行两次,持续一个月。评估包括使用伯格平衡量表进行的首次、中期和最终评估。此外,采用统计检验确定组间给药对提高老年人平衡能力的影响,而采用独立t检验确定组间给药对提高老年人平衡能力的影响。结果:重复测量方差分析结果显示,两组的<i>p</i>-值均为球形(<i>p</i>=.000),说明两组均改善了老年人的平衡能力。独立t检验发现,假设<i>p</i>-值相等方差(<i>p</i>=.572),这表明两组在增加老年人平衡方面的效果没有差异。结论:单腿站立训练与核心稳定性训练、桥接训练与核心稳定性训练在改善老年人平衡方面无显著差异。
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引用次数: 0
Effects of Isotonic Core Exercise with Weight Loss on Low Back Pain, Core Strength and Balance in Obese Middle-Aged Women 减肥等张核心运动对肥胖中年妇女腰痛、核心力量和平衡的影响
Q4 Health Professions Pub Date : 2023-08-31 DOI: 10.15857/ksep.2023.00381
Woo-Jung Lee, Yun-Hwan Lee, Ji-Eun Lee, Ho-Seong Lee
PURPOSE: This study aimed to investigate the effects of concurrent core exercises and weight loss on lower back pain, core muscle strength, and balance in middle-aged obese women.METHODS: Eighteen middle-aged obese women were randomly assigned to the core exercise with weight loss (CE+WL, n=6), core exercise (CE, n=6), and control (CON, n=6) groups. Moreover, CE was conducted for 60 minutes, three times a week for 8 weeks, with a weight loss goal of approximately 0.5-1 kg per week. All participants underwent measurements of body composition (weight, body mass index, percentage body fat, muscle mass, waist-to-hip ratio (WHR), low back pain (visual analogue scale [VAS]), core muscle strength (hip flexor), and balance (sensory organization, reaction time, and motor control)) before the experiment, at 4 and 8 weeks.RESULTS: A significant decrease in WHR was observed at 4 and 8 weeks of exercise compared to that before exercise in both the CE+WL and CE groups (p<.05). Additionally, VAS scores significantly decreased at 4 and 8 weeks compared to those before exercise in the CE+WL group and a decrease was observed at 8 weeks in the CE group (p<.05). Hip flexor strength significantly increased at 8 weeks of exercise compared to that before exercise in the CE+WL group (p<.05). Furthermore, hip flexor strength also significantly increased at 4 and 8 weeks in the CE group (p<.05). Sensory organization significantly increased at C2 after 8 weeks of exercise compared with that before exercise in the CE+WL group (p<.05).CONCLUSION: The results of this study suggested that combining CE with WL concurrently leads to improvements in WHR, back pain, hip flexor strength, and sensory organization in middle-aged obese women.
目的:本研究旨在探讨同时进行核心运动和减肥对中年肥胖女性腰痛、核心肌肉力量和平衡的影响。方法:18名中年肥胖女性随机分为核心运动减重组(CE+WL, n=6)、核心运动组(CE, n=6)和对照组(CON, n=6)。此外,CE进行60分钟,每周三次,持续8周,减肥目标约为0.5-1 kg /周。所有参与者在实验前4周和8周进行了身体组成(体重、身体质量指数、体脂百分比、肌肉质量、腰臀比(WHR)、腰背痛(视觉模拟量表[VAS])、核心肌肉力量(髋屈肌)和平衡(感觉组织、反应时间和运动控制)的测量。结果:与运动前相比,CE+WL组和CE组在运动第4周和第8周时腰宽比均显著降低(<i>p</i>< 0.05)。此外,与运动前相比,CE+WL组的VAS评分在4周和8周时显著下降,CE组在8周时观察到下降(<i>p</i>< 0.05)。与运动前相比,CE+WL组在运动8周时髋屈肌力量显著增加(<i>p</i>< 0.05)。此外,CE组在第4周和第8周时髋屈肌力量也显著增加(<i>p</i>< 0.05)。与运动前相比,CE+WL组运动8周后C2感觉组织显著增加(<i>p</i>< 0.05)。结论:本研究结果表明,CE与WL同时结合可改善中年肥胖女性的腰腰比、背痛、髋屈肌力量和感觉组织。
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引用次数: 0
Effects of Regular Aerobic Exercise Interventions on Decreased Cerebral Blood Flow-Induced Mild Cognitive Impairment 定期有氧运动干预对减少脑血流诱导的轻度认知障碍的影响
Q4 Health Professions Pub Date : 2023-08-31 DOI: 10.15857/ksep.2023.00255
Dong-Hyun Lee, Soon-Chang Sung, Kwang-Seok Hong
PURPOSE: Decreased cerebral blood flow (CBF) is a common symptom in older adults with mild cognitive impairment (MCI). Aerobic exercise is a promising therapeutic intervention for delaying or ameliorating age-related CBF deterioration in older individuals. The review outlines the differences in CBF between healthy older individuals and those with MCI, as well as the benefits of aerobic exercise in augmenting CBF in older adults.METHODS: We used academic search engines, including PubMed, Web of Science, Scopus, Google Scholar, and the Wiley Online Library, to identify studies demonstrating alterations in CBF with aging and the preventive and therapeutic effects of aerobic exercise on CBF in older adults. The keywords included ‘mild cognitive impairment,’ ‘elderly or older people,’ ‘cerebral blood flow,’ ‘cerebral perfusion,’ and ‘aerobic exercise.’RESULTS: Aerobic exercise improves or maintains health by enhancing CBF and cognitive function in healthy older individuals. The beneficial impact applies to older people with MCI, although research has been inconsistent regarding aerobic exercise-induced alterations in CBF.CONCLUSIONS: Aerobic exercise is a promising treatment for MCI in older adults and promotes CBF and cognitive function. However, some studies have reported inconsistent findings regarding changes in CBF. The inconsistencies may be due to several factors, including health and age. Further investigations are warranted to delineate the effects of aerobic exercise on CBF in older adults with MCI.
目的:脑血流量减少(CBF)是老年人轻度认知障碍(MCI)的常见症状。有氧运动是一种很有前景的治疗干预措施,可以延缓或改善老年人与年龄相关的CBF恶化。该综述概述了健康老年人与轻度认知障碍患者之间脑血流的差异,以及有氧运动对增强老年人脑血流的益处。方法:我们使用学术搜索引擎,包括PubMed、Web of Science、Scopus、Google Scholar和Wiley Online Library,来识别证明CBF随年龄变化的研究,以及有氧运动对老年人CBF的预防和治疗作用。关键词包括“轻度认知障碍”、“老年人”、“脑血流量”、“脑灌注”和“有氧运动”。结果:有氧运动通过增强健康老年人的脑血流和认知功能来改善或维持健康。这种有益的影响适用于患有轻度认知障碍的老年人,尽管关于有氧运动引起的CBF改变的研究一直不一致。结论:有氧运动是治疗老年人轻度认知损伤的一种有希望的治疗方法,可以促进脑血流和认知功能。然而,一些研究报告了关于CBF变化的不一致的发现。这种不一致可能是由几个因素造成的,包括健康和年龄。需要进一步的研究来描述有氧运动对老年轻度认知损伤患者脑血流的影响。
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引用次数: 0
Prediction Models of Blood Glucose Change During Aerobic Exercise Using Machine Learning Techniques 利用机器学习技术预测有氧运动期间血糖变化的模型
Q4 Health Professions Pub Date : 2023-08-31 DOI: 10.15857/ksep.2023.00318
Okimitsu Oyama, Seonggyu Choi, Changgeun Oh, Eunchan Kim, Dong-Hyuk Park, Minsuk Oh, Dae-hyun Park, Hye-Kyoung Seo, jungsun Han, Dongiae Jeon, Seong-Hyok Kim, Justin Y Jeon
PURPOSE: This study aimed to explore the relationship between blood glucose level changes and body characteristics during exercise and to present six models for predicting changes in blood glucose levels during exercise.METHODS: 148 healthy men and women (age: 31.9±9.7 year, fasting blood glucose: 102.1±14.1 mg/dL, p=.032) participated in the study, and 30 of them participated in the study. Eight variables were selected to build two prediction models: 24-hour ingested carbohydrates, age, blood glucose, heart rate changes, sex, skeletal muscle mass, heart rate recovery after exercise, and resting heart rate. Logistic regression and random forest classifier models were used to predict the changes in blood glucose levels during exercise.RESULTS: A total of six models were created for all participants, male and female. Random forest classification (training set: AUC=0.837, Youden index=0.66; validation set: AUC=0.730, Youden index=0.53) and logistic regression classification models (training set: AUC=0.807, Youden index=0.55; validation set: AUC=0.735, Youden index=0.57) were built.CONCLUSION: The random forest model showed good performance in classifying internal data, whereas the logistic regression classification model demonstrated relatively good performance in classifying validation data.
目的:本研究旨在探讨运动过程中血糖水平变化与身体特征的关系,并提出6种预测运动过程中血糖水平变化的模型。方法:148名健康男女(年龄:31.9±9.7岁,空腹血糖:102.1±14.1 mg/dL, <i>p</i>= 0.032)参与研究,其中30人参加研究。选取24小时碳水化合物摄取量、年龄、血糖、心率变化、性别、骨骼肌量、运动后心率恢复、静息心率8个变量,建立2个预测模型。采用Logistic回归和随机森林分类模型预测运动期间血糖水平的变化。结果:所有参与者(男、女)共建立了6个模型。随机森林分类(训练集:AUC=0.837,约登指数=0.66;验证集:AUC=0.730,约登指数=0.53)和逻辑回归分类模型(训练集:AUC=0.807,约登指数=0.55;建立AUC=0.735, Youden指数=0.57的验证集。结论:随机森林模型对内部数据分类效果较好,而逻辑回归模型对验证数据分类效果较好。
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引用次数: 0
Effects of Resistance Exercise on Older Individuals with Sarcopenia: Sex Differences in Humans 抗阻运动对老年肌肉减少症患者的影响:人类的性别差异
Q4 Health Professions Pub Date : 2023-08-31 DOI: 10.15857/ksep.2023.00346
Ki-woong Noh, Sok Park
Sarcopenia affects tens of millions of adults worldwide, with a reported prevalence of 10-50% among older adults. A decrease in muscle strength and function due to aging reduces physical performance, causing pain and disease. Accordingly, interest in the treatment or prevention of sarcopenia through resistance exercises, which have been found to be effective in improving muscle strength and hypertrophy, is increasing. However, given the individual differences, it is difficult to determine the optimal RE method. Currently, the importance of personalized resistance exercise (RE) prescriptions is emphasized, and research on sex/gender differences needs to be conducted. Our review focused on the effects of resistance exercise on muscle strength, muscle hypertrophy, and muscle function in older adults in relation to sex differences. In this review, we aimed to analyze sex differences in the effect of RE on older adults with sarcopenia and provide meaningful information for future research on exercise programs for individuals with sarcopenia.
骨骼肌减少症影响着全世界数千万成年人,据报道,老年人的患病率为10-50%。由于年龄的增长,肌肉力量和功能的下降会降低身体机能,导致疼痛和疾病。因此,人们越来越关注通过抗阻运动来治疗或预防肌肉减少症,因为抗阻运动已被发现能有效地改善肌肉力量和肥厚。然而,由于个体差异,很难确定最优的RE方法。目前强调个性化抗阻运动处方的重要性,需要对性别差异进行研究。我们的综述集中在阻力运动对老年人肌肉力量、肌肉肥大和肌肉功能的影响与性别差异的关系上。在这篇综述中,我们旨在分析RE对老年肌肉减少症患者影响的性别差异,并为未来研究肌肉减少症患者的运动计划提供有意义的信息。
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引用次数: 0
Association between Weight Loss and Hand-Grip Strength with Cause-Specific Mortality in Middle-Aged and Older Adults 中老年人体重减轻和握力与死因特异性死亡率之间的关系
Q4 Health Professions Pub Date : 2023-08-31 DOI: 10.15857/ksep.2023.00332
Inhwan Lee
PURPOSE: This study investigated the association between weight loss and handgrip strength (HGS) with cause-specific mortality in middle-aged and older adults.METHODS: A total of 8,175 participants (54.1% women) aged ≥45 years, who participated in the Korean longitudinal study of aging (KLoSA) were included. Study participants were classified as stable weight and 5 kg or more weight loss group based on weight change and as high, middle, and low categories based on HGS distributions. Cox proportional hazards regression model was used to calculate hazard ratio (HR) according to weight change status and HGS levels.RESULTS: During 13.0±3.1 years of follow-up, there were 1,809 (22.1%) deaths. In all-cause mortality, middle HGS (stable weight; HR=1.289, p<.001; weight loss; HR=1.723, p<.001) and low HGS (stable weight; HR=1.665, p<.001; weight loss; HR=2.488, p<.001) resulted in an increased risk of mortality compared to stable weight and high HGS (HR=1). Similarly, in non-CVD mortality, middle HGS (stable weight; HR=1.241, p=.005; weight loss; HR=1.816, p<.001) and low HGS (stable weight; HR=1.611, p<.001; weight loss; HR=2.658, p<.001) resulted in an increased risk of mortality compared to stable weight and high HGS (HR=1). However, in the high HGS category, no significant differences in the risk of all-cause and non-CVD mortality according to weight change were observed.CONCLUSIONS: The current finding suggested that the promotion of upper body muscular strength may play an important role in preventing premature death from all-cause and non-CVD, especially among those who suffer from weight loss.
目的:本研究调查了中老年人体重减轻和握力(HGS)与病因特异性死亡率之间的关系。方法:共纳入8175名年龄≥45岁、参加韩国老龄化纵向研究(KLoSA)的参与者(54.1%为女性)。研究参与者根据体重变化分为稳定体重组和5公斤及以上减肥组,根据HGS分布分为高、中、低三类。采用Cox比例风险回归模型,根据体重变化情况和HGS水平计算风险比(HR)。结果:随访13.0±3.1年,死亡1809例(22.1%)。在全因死亡率中,中等HGS(体重稳定;HR = 1.289, & lt; i>术中;/ i> & lt;措施;减肥;HR=1.723, <i> </i><.001)和低HGS(稳定体重;HR = 1.665, & lt; i>术中;/ i> & lt;措施;减肥;HR=2.488, <i>p</i><.001)导致与稳定体重和高HGS相比死亡风险增加(HR=1)。同样,在非心血管疾病死亡率中,中等HGS(体重稳定;HR = 1.241, & lt; i>术中;/ i> = .005;减肥;HR=1.816, <i> </i><.001)和低HGS(稳定体重;HR = 1.611, & lt; i>术中;/ i> & lt;措施;减肥;HR=2.658, <i>p</i><.001)导致与稳定体重和高HGS相比死亡风险增加(HR=1)。然而,在高HGS类别中,根据体重变化,未观察到全因和非心血管疾病死亡风险的显着差异。结论:目前的研究结果表明,促进上肢肌肉力量可能在预防全因和非心血管疾病导致的过早死亡中发挥重要作用,特别是在体重减轻的人群中。
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引用次数: 0
Development of Handball Academy Korea Physical Fitness Test Model for Youth Handball Players 韩国手球学院青少年手球运动员体能测试模型的开发
Q4 Health Professions Pub Date : 2023-08-31 DOI: 10.15857/ksep.2023.00094
MinKi Kim, Jong Chul Park, Jee Hwan Ahn, Soo Hyun Park
PURPOSE: This study aimed to develop a Handball Academy Korea Physical Fitness Test Battery for youth handball athletes considering their characteristics using the Delphi/AHP method.METHODS: After reviewing previous studies, an expert meeting was held to draft a battery. To select physical fitness variables, 17 experts with more than 10 years of research or coaching experience in related fields were invited. The contact validity of each variable was verified using the 1st and 2nd Delphi surveys. A decision-making method based on the analytic hierarchy process (AHP) was used to assign weights to each factor in the final physical fitness battery, which was selected based on the results of the Delphi survey.RESULTS: Ten physical fitness factors, namely, length (CVR=1.00), weight (CVR=0.67), muscle strength (CVR=0.67), muscular endurance (CVR=0.83), cardiorespiratory fitness (CVR=0.83), flexibility (CVR=0.67), power (CVR=1.00), agility (CVR=1.00), speed (CVR=0.80), coordination (CVR=1.00), were determined. As test variables for physical fitness, height (CVR=0.83), arm span (CVR=0.67), lean body mass (CVR=0.64), handgrip strength (CVR=0.83), push-up (CVR=0.67), 20 m shuttle run (CVR=1.00), sitand-reach (CVR=0.83), standing long jump (CVR=0.76), countermovement jump (CVR=0.67), ball speed (CVR=0.67), rollercoaster run (CVR=0.83), visual reaction (CVR=0.83), 20 m sprint (CVR=0.83), and ball handling (CVR=0.67) were found to be valid. Weight was calculated according to the relative importance of the determined variables.CONCLUSIONS: The present findings indicate that the Handball Academy Korea Physical Fitness Test Battery can be used to evaluate the physical fitness of youth handball athletes and select potential players.
目的:本研究旨在结合青少年手球运动员的特点,采用德尔菲/层次分析法开发青少年手球运动员体能测试单元。方法:在回顾以往的研究后,召开专家会议起草一份报告。为了选择体质变量,我们邀请了17位在相关领域具有10年以上研究或教练经验的专家。每个变量的接触效度通过第一次和第二次德尔菲调查进行验证。采用基于层次分析法(AHP)的决策方法,根据德尔菲调查的结果,对最终体质单元的各个因素进行权重分配。结果:测定了身高(CVR=1.00)、体重(CVR=0.67)、肌力(CVR=0.67)、肌肉耐力(CVR=0.83)、心肺适能(CVR=0.83)、柔韧性(CVR=0.67)、力量(CVR=1.00)、敏捷性(CVR=1.00)、速度(CVR=0.80)、协调性(CVR=1.00) 10项体质指标。体能测试变量为身高(CVR=0.83)、臂展(CVR=0.67)、瘦体质量(CVR=0.64)、握力(CVR=0.83)、俯卧撑(CVR=0.67)、20米飞毛腿跑(CVR=1.00)、仰卧起坐(CVR=0.83)、立定跳远(CVR=0.76)、反向跳(CVR=0.67)、球速(CVR=0.67)、过山车跑(CVR=0.83)、视觉反应(CVR=0.83)、20米冲刺(CVR=0.83)、持球(CVR=0.67)。根据确定变量的相对重要性计算权重。结论:本研究结果表明,韩国手球学院体能测试组可用于青少年手球运动员体能评估和潜力运动员的选拔。
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引用次数: 0
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Exercise Science
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