Pub Date : 2023-03-15DOI: 10.18231/j.jdpo.2023.009
Preeti Joseph, N. Gupta, Lav Behl, Mehak, Sanjeev Uppal
Lymphangioma circumscriptum (LC) is a distention of lymphatic channels present in skin and subcutaneous tissues. LC is either primary (usually present at birth or develops in early childhood) or secondary due to diminished lymphatic outflow. It is commonly prone to develop in oral cavity, tongue, proximal regions of arms and legs, groin, axilla, and trunk. Primary vulvar involvement is unusual. Vulvar LC is a rare untoward outcome of hidradenitis suppurativa (HS), which causes significant physical and emotional discomfort. We report a case of acquired LC of vulva as a sequlae of HS in a 42 years old female who presented with painful papules, edema and thickening of the vulva with history of foul-smelling discharging sinuses. The patient was managed surgically by wide excision and reconstructive surgery by Plastic surgery unit.
{"title":"Acquired lymphangioma circumscriptum of the vulva in a middle aged woman with chronic hidradenitis suppurativa – A case report","authors":"Preeti Joseph, N. Gupta, Lav Behl, Mehak, Sanjeev Uppal","doi":"10.18231/j.jdpo.2023.009","DOIUrl":"https://doi.org/10.18231/j.jdpo.2023.009","url":null,"abstract":"Lymphangioma circumscriptum (LC) is a distention of lymphatic channels present in skin and subcutaneous tissues. LC is either primary (usually present at birth or develops in early childhood) or secondary due to diminished lymphatic outflow. It is commonly prone to develop in oral cavity, tongue, proximal regions of arms and legs, groin, axilla, and trunk. Primary vulvar involvement is unusual. Vulvar LC is a rare untoward outcome of hidradenitis suppurativa (HS), which causes significant physical and emotional discomfort. We report a case of acquired LC of vulva as a sequlae of HS in a 42 years old female who presented with painful papules, edema and thickening of the vulva with history of foul-smelling discharging sinuses. The patient was managed surgically by wide excision and reconstructive surgery by Plastic surgery unit.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115128404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.jdpo.2023.014
C. Gupta, Rajat Gupta
A diverse range of inflammatory, cystic and neoplastic processes affect salivary glands.Fine needle aspiration cytology (FNAC) is a reliable tool for evaluation of salivary gland lesions. To analyse the cytomorphological features of salivary gland lesions and to assess the frequency of distribution of these lesions. It was an observational study conducted in the Department of Pathology, Govt. Medical College, Jammu. FNAC was performed on patients presenting with salivary gland swelling. May-Grunwald-Giemsa (MGG) and Papanicolaou (PAP) stained smears were examined under light microscope. The cytomorphological features were analysed and diagnosis was made. There were 65 cases which included 31 (47.7%) males and 34 (52.3%) females. The mean age of patients was 42.96 years. On microscopic examination, neoplastic lesions were 35 (53.8%) and non neoplastic lesions were 30 (46.2%). Pleomorphic adenoma was the most common benign neoplastic lesion and also was the most frequently diagnosed lesion in our study (21, 32.3%). Mucoepidermoid carcinoma cases were maximum among malignant lesions (4, 6.2%). Parotid gland was involved in majority of cases. FNAC is a simple, rapid, reliable tool for the evaluation of salivary gland lesions thereby helping clinicians in deciding the further management plan.
{"title":"Patterns of salivary gland lesions on fine needle aspiration cytology (FNAC)","authors":"C. Gupta, Rajat Gupta","doi":"10.18231/j.jdpo.2023.014","DOIUrl":"https://doi.org/10.18231/j.jdpo.2023.014","url":null,"abstract":"A diverse range of inflammatory, cystic and neoplastic processes affect salivary glands.Fine needle aspiration cytology (FNAC) is a reliable tool for evaluation of salivary gland lesions. To analyse the cytomorphological features of salivary gland lesions and to assess the frequency of distribution of these lesions. It was an observational study conducted in the Department of Pathology, Govt. Medical College, Jammu. FNAC was performed on patients presenting with salivary gland swelling. May-Grunwald-Giemsa (MGG) and Papanicolaou (PAP) stained smears were examined under light microscope. The cytomorphological features were analysed and diagnosis was made. There were 65 cases which included 31 (47.7%) males and 34 (52.3%) females. The mean age of patients was 42.96 years. On microscopic examination, neoplastic lesions were 35 (53.8%) and non neoplastic lesions were 30 (46.2%). Pleomorphic adenoma was the most common benign neoplastic lesion and also was the most frequently diagnosed lesion in our study (21, 32.3%). Mucoepidermoid carcinoma cases were maximum among malignant lesions (4, 6.2%). Parotid gland was involved in majority of cases. FNAC is a simple, rapid, reliable tool for the evaluation of salivary gland lesions thereby helping clinicians in deciding the further management plan.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131070635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.jdpo.2023.002
Dhanashri Rabha, J. Devi
Urine cytology is an important screening tool for detection of high grade urothelial carcinoma and follow-up of patients with treated disease. Ease of procurement, cost-effectiveness, and lower turnaround time are the major advantages of the system. We aim to determine the frequency of high grade and low grade urothelial carcinoma in urine cytology specimens and to evaluate the accuracy of Paris system. A retrospective study was conducted in the Department of Pathology (Cytology), GMCH from August 2020 to July 2022 where a total of 200 cases were included. Data along with the preserved slides of urine cytology of these cases were collected from the archives and examined for the presence of urothelial carcinoma. The results were calculated in Microsoft word and excel, and p value was calculated by using the Chi- square (χ2) test of significance, P values less than 0.05 was considered statistically significant. In our study, a total of 200 cases were analysed, 169 were males and 31 were females, the male to female ratio being 5.5: 1. The most commonly affected age group was 61-70 years, the mean age being 62 years. Of the 200 urine samples examined, 12.5% cases had High Grade Urothelial Carcinoma (HGUC), 13.5% cases had atypical urothelial cells, 9% cases were suspicious for HGUC and 2% cases had Low Grade Urothelial Neoplasm. : The Paris System is a highly sensitive and rapid tool for reporting urine cytology specimens and is particularly useful in diagnosing High Grade Urothelial Carcinoma thereby helping in early management of the patients with neoplastic lesions of the urinary bladder.
{"title":"Paris system of reporting urine cytology: An important screening tool for urothelial neoplasms","authors":"Dhanashri Rabha, J. Devi","doi":"10.18231/j.jdpo.2023.002","DOIUrl":"https://doi.org/10.18231/j.jdpo.2023.002","url":null,"abstract":"Urine cytology is an important screening tool for detection of high grade urothelial carcinoma and follow-up of patients with treated disease. Ease of procurement, cost-effectiveness, and lower turnaround time are the major advantages of the system. We aim to determine the frequency of high grade and low grade urothelial carcinoma in urine cytology specimens and to evaluate the accuracy of Paris system. A retrospective study was conducted in the Department of Pathology (Cytology), GMCH from August 2020 to July 2022 where a total of 200 cases were included. Data along with the preserved slides of urine cytology of these cases were collected from the archives and examined for the presence of urothelial carcinoma. The results were calculated in Microsoft word and excel, and p value was calculated by using the Chi- square (χ2) test of significance, P values less than 0.05 was considered statistically significant. In our study, a total of 200 cases were analysed, 169 were males and 31 were females, the male to female ratio being 5.5: 1. The most commonly affected age group was 61-70 years, the mean age being 62 years. Of the 200 urine samples examined, 12.5% cases had High Grade Urothelial Carcinoma (HGUC), 13.5% cases had atypical urothelial cells, 9% cases were suspicious for HGUC and 2% cases had Low Grade Urothelial Neoplasm. : The Paris System is a highly sensitive and rapid tool for reporting urine cytology specimens and is particularly useful in diagnosing High Grade Urothelial Carcinoma thereby helping in early management of the patients with neoplastic lesions of the urinary bladder.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115271592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.jdpo.2023.010
Khushboo, B. Kumar, R. Chandra, Vinay Mishra
Peritoneal mesothelioma being a rare tumor is difficult to diagnose and start treatment. Pleura is the most common area being affected by mesothelioma, peritoneum being the second common site, and in some cases synchronous pleural and peritoneal mesotheliomas are observed (30–45% of the cases). The presentation of mesothelioma is not up to mark leading to difficulty in diagnosis due to lack of specific symptoms and clinical findings. In addition, in the absence of previous asbestos exposure a delay in the diagnosis is not rare. Here we report a case of malignant peritoneal mesotheliomas. The diagnostic and therapeutic approaches for these rare neoplasms are discussed. A 24 year old male patient was admitted with complaints of pain abdomen (on & off) and abdominal distension since 15 days, with no inhalational exposure to asbestos, causing diagnostic confusion. He had history of unresolving haemorrhagic ascites. No drug allergy was noted. Diagnostic laproscopy was done, shows multiple omental nodules. Omental biopsy along with immunohistochemistry leads to diagnosis of malignant peritoneal mesothelioma. Peritoneal mesotheliomas are infrequent clinical entities. However, patients presenting with prolonged abdominal pain and ascitis should be considered to have atypical pathologies with peritoneal mesotheliomas being one of the differentials.
{"title":"Malignant peritoneal mesothelioma with unresolving haemorrhagic ascites- A case report","authors":"Khushboo, B. Kumar, R. Chandra, Vinay Mishra","doi":"10.18231/j.jdpo.2023.010","DOIUrl":"https://doi.org/10.18231/j.jdpo.2023.010","url":null,"abstract":"Peritoneal mesothelioma being a rare tumor is difficult to diagnose and start treatment. Pleura is the most common area being affected by mesothelioma, peritoneum being the second common site, and in some cases synchronous pleural and peritoneal mesotheliomas are observed (30–45% of the cases). The presentation of mesothelioma is not up to mark leading to difficulty in diagnosis due to lack of specific symptoms and clinical findings. In addition, in the absence of previous asbestos exposure a delay in the diagnosis is not rare. Here we report a case of malignant peritoneal mesotheliomas. The diagnostic and therapeutic approaches for these rare neoplasms are discussed. A 24 year old male patient was admitted with complaints of pain abdomen (on & off) and abdominal distension since 15 days, with no inhalational exposure to asbestos, causing diagnostic confusion. He had history of unresolving haemorrhagic ascites. No drug allergy was noted. Diagnostic laproscopy was done, shows multiple omental nodules. Omental biopsy along with immunohistochemistry leads to diagnosis of malignant peritoneal mesothelioma. Peritoneal mesotheliomas are infrequent clinical entities. However, patients presenting with prolonged abdominal pain and ascitis should be considered to have atypical pathologies with peritoneal mesotheliomas being one of the differentials.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120927737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.jdpo.2023.001
Ekaparna Hazarika, J. Devi
Hepatobiliary and Pancreatic mass lesions are commonly occurring intra-abdominal space occupying lesions. Image guided FNAC enables exact localization of the lesion, assessment of nature and invasion and is a useful tool in the diagnosis of such lesions. The present study aims to evaluate the spectrum of hepatobiliary mass lesions diagnosed by Image guided FNAC. We have conducted a retrospective study in Department of Pathology, Gauhati Medical College & Hospital, Guwahati, for a period of 5 years, including patients of all ages and both sexes presenting with clinical and radiological suspicion of hepatic, biliary or pancreatic mass lesion. Under aseptic conditions USG guidance FNAC was done from the appropriate site and smears were examined. Out of the total 135 patients, there were 70 cases of Hepatic lesions (51.8%), followed by 54 cases taken from Gall bladder (GB) (40%), 5 cases from Common Bile Duct (CBD) (3.7%) and 6 cases (4.44%) from Pancreatic lesions. There were 51 cases of hepatic malignancies, 36 GB malignancies, 4 cases each of CBD and pancreatic malignancies. The most common Hepatic malignancies were Metastases followed by Hepatocellular carcinoma. The most common GB malignancy was Adenocarcinoma, followed by Cholangiocarcinoma. There was 1 case each of Solid Pseudopapillary Neoplasm of Pancreas, Acinar Cell carcinoma, Mucinous Adenocarcinoma and HCC. These findings were in concordance with our reference studies. Image guided FNAC has proved to be a versatile tool in provide an early and accurate diagnosis of hepatobiliary and pancreatic mass lesions.
{"title":"Cytological evaluation of spectrum of Hepatobiliary and Pancreatic mass lesions","authors":"Ekaparna Hazarika, J. Devi","doi":"10.18231/j.jdpo.2023.001","DOIUrl":"https://doi.org/10.18231/j.jdpo.2023.001","url":null,"abstract":"Hepatobiliary and Pancreatic mass lesions are commonly occurring intra-abdominal space occupying lesions. Image guided FNAC enables exact localization of the lesion, assessment of nature and invasion and is a useful tool in the diagnosis of such lesions. The present study aims to evaluate the spectrum of hepatobiliary mass lesions diagnosed by Image guided FNAC. We have conducted a retrospective study in Department of Pathology, Gauhati Medical College & Hospital, Guwahati, for a period of 5 years, including patients of all ages and both sexes presenting with clinical and radiological suspicion of hepatic, biliary or pancreatic mass lesion. Under aseptic conditions USG guidance FNAC was done from the appropriate site and smears were examined. Out of the total 135 patients, there were 70 cases of Hepatic lesions (51.8%), followed by 54 cases taken from Gall bladder (GB) (40%), 5 cases from Common Bile Duct (CBD) (3.7%) and 6 cases (4.44%) from Pancreatic lesions. There were 51 cases of hepatic malignancies, 36 GB malignancies, 4 cases each of CBD and pancreatic malignancies. The most common Hepatic malignancies were Metastases followed by Hepatocellular carcinoma. The most common GB malignancy was Adenocarcinoma, followed by Cholangiocarcinoma. There was 1 case each of Solid Pseudopapillary Neoplasm of Pancreas, Acinar Cell carcinoma, Mucinous Adenocarcinoma and HCC. These findings were in concordance with our reference studies. Image guided FNAC has proved to be a versatile tool in provide an early and accurate diagnosis of hepatobiliary and pancreatic mass lesions.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133526858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clear cell sarcoma of soft tissue is a rare malignant neoplasm which constitutes about 1% of soft tissue tumors. It most commonly arises in the distal extremities of young adults. Peak incidence is in the third decade. More commonly seen in women than men. A 30 year old female presented with swelling in right supraclavicular region associated with pain since 3 months. CT scan findings revealed irregular and non-enhancing, hypodense lesion measuring 2.5x2x1cm in right supraclavicular region. Cytological features revealed abundant cellularity comprising of atypical cells mainly dispersed singly and arranged in loose cohesive groups. The cytoplasm was abundant, vacuolated at places, pleomorphic round to oval nucleus, placed centrally to eccentrically with prominent nucleoli. Diagnosis of malignant mesenchymal neoplasm was made on the basis of the cytomorphological details. Clear cell sarcoma was included in the differential diagnosis. Cytomorphological diagnosis was confirmed by histological and immunohistochemical diagnosis. When cytology of a soft tissue tumor shows high cellularity alongwith dispersion and loosely cohesiveness of cells, nuclear pleomorphism and conspicuous nucleoli, diagnosis of clear cell sarcoma may be considered.
{"title":"Clear cell sarcoma of soft tissue arising in the supraclavicular region: A cytological diagnosis","authors":"Pooja Rathee, R. Verma, Ritu, Vibhuti Thukral, Sumiti Gupta, Sunita Singh","doi":"10.18231/j.jdpo.2023.011","DOIUrl":"https://doi.org/10.18231/j.jdpo.2023.011","url":null,"abstract":"Clear cell sarcoma of soft tissue is a rare malignant neoplasm which constitutes about 1% of soft tissue tumors. It most commonly arises in the distal extremities of young adults. Peak incidence is in the third decade. More commonly seen in women than men. A 30 year old female presented with swelling in right supraclavicular region associated with pain since 3 months. CT scan findings revealed irregular and non-enhancing, hypodense lesion measuring 2.5x2x1cm in right supraclavicular region. Cytological features revealed abundant cellularity comprising of atypical cells mainly dispersed singly and arranged in loose cohesive groups. The cytoplasm was abundant, vacuolated at places, pleomorphic round to oval nucleus, placed centrally to eccentrically with prominent nucleoli. Diagnosis of malignant mesenchymal neoplasm was made on the basis of the cytomorphological details. Clear cell sarcoma was included in the differential diagnosis. Cytomorphological diagnosis was confirmed by histological and immunohistochemical diagnosis. When cytology of a soft tissue tumor shows high cellularity alongwith dispersion and loosely cohesiveness of cells, nuclear pleomorphism and conspicuous nucleoli, diagnosis of clear cell sarcoma may be considered.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132281160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.jdpo.2023.007
Ashutosh Ramaswamy, A.A. Khan
The rapid global spread of the novel coronavirus SARS CoV-2 has strained the existing healthcare and tested our resources. Many studies have found that the ABO blood group plays an important role in various human diseases, such as cardiovascular, oncological, and some infectious and non-infectious diseases. The present study was conducted to study the association of ABO and Rh blood groups with COVID-19 susceptibility and severity. This study was conducted on 209 COVID-19-confirmed patients admitted for their management. Cases were categorized as mild, moderate and severe as per the protocol. The ABO/Rh blood groups of these patients were determined by the gel card method. A total of 209 COVID positive patients were included in this present study. Most of the patients susceptible to COVID belonged to B positive blood group (33.01%) followed by O positive (32.06%). The severity of COVID-19 infection was most common in patients with O positive blood group (37.4%). COVID-19 infection was more common in males and more prevalent in B and O-positive blood groups.
{"title":"Exploring the relationship between ABO and Rh blood groups and susceptibility to COVID-19 infection","authors":"Ashutosh Ramaswamy, A.A. Khan","doi":"10.18231/j.jdpo.2023.007","DOIUrl":"https://doi.org/10.18231/j.jdpo.2023.007","url":null,"abstract":"The rapid global spread of the novel coronavirus SARS CoV-2 has strained the existing healthcare and tested our resources. Many studies have found that the ABO blood group plays an important role in various human diseases, such as cardiovascular, oncological, and some infectious and non-infectious diseases. The present study was conducted to study the association of ABO and Rh blood groups with COVID-19 susceptibility and severity. This study was conducted on 209 COVID-19-confirmed patients admitted for their management. Cases were categorized as mild, moderate and severe as per the protocol. The ABO/Rh blood groups of these patients were determined by the gel card method. A total of 209 COVID positive patients were included in this present study. Most of the patients susceptible to COVID belonged to B positive blood group (33.01%) followed by O positive (32.06%). The severity of COVID-19 infection was most common in patients with O positive blood group (37.4%). COVID-19 infection was more common in males and more prevalent in B and O-positive blood groups.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117173292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nevus lipomatosis cutaneous superficialis (NLCS) is a rare cutaneous hamartomatous lesion or connective tissue nevus having two clinical forms a). classical Hoffman-Zurhelle form and b). solitary form. We report a classical case of nevus lipomatosus superficialis in a 35-year-old male in the left flank. Histopathology showed presence of ectopic mature adipocytes extending to the papillary dermis with no connection to underlying subcutaneous fat, thus clinching our diagnosis. Excision is the ultimate cure with minimal chance of recurrence.
{"title":"Nevus lipomatosis cutaneous superficialis – A rare hamartoma","authors":"Shushruta Mohanty, Ekta Mishra, Deepika Sahu, Deepika Mishra","doi":"10.18231/j.jdpo.2023.013","DOIUrl":"https://doi.org/10.18231/j.jdpo.2023.013","url":null,"abstract":"Nevus lipomatosis cutaneous superficialis (NLCS) is a rare cutaneous hamartomatous lesion or connective tissue nevus having two clinical forms a). classical Hoffman-Zurhelle form and b). solitary form. We report a classical case of nevus lipomatosus superficialis in a 35-year-old male in the left flank. Histopathology showed presence of ectopic mature adipocytes extending to the papillary dermis with no connection to underlying subcutaneous fat, thus clinching our diagnosis. Excision is the ultimate cure with minimal chance of recurrence.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115111499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-15DOI: 10.18231/j.jdpo.2022.052
Sneha Aditi, R. Naik
Benign prostatic hyperplasia (BPH) and prostate adenocarcinoma are the most common disorders affecting elderly men. The diseases are androgen-dependent and are treated by obstructing androgen receptor (AR) or their action. AR has direct relationship between the development of prostatic hyperplasia and prostatic carcinoma. Estrogens directly target prostate tissue by definite estrogen receptors (ER). The human prostate is primed with a dual system of ERs (ER-α and ER-β). Use of estrogens as hormonal agents is for suppressing prostatic tissue growth. Study aims to identify, assess and establish the significance of ER and AR as a marker in distinguishing BPH and prostatic carcinoma. A cross sectional study was conducted at a tertiary care hospital over a period of two year on 65 specimens which included 30 malignant cases and 35 benign cases. Specimens received were tru-cut biopsy, transurethral resection of prostate chips (TURP) and prostatectomy specimen for malignant cases and TURP for benign lesions. Paraffin embedded blocks was stained with H&E and IHC with ER and AR performed on representative sections and graded .the results were assessed for association with various parameters in both benign and malignant cases. Out of 30 cases of adenocarcinoma of prostate majority of specimens were needle biopsies (54%). The age of presentation was 55-84 years with mean age being 68.93 years. In cases of BPH the presenting age was 35-84 years and mean age was 63 years. Histopathological parameters assessed for malignant lesions, showed negative correlation of grade group with PNI and positive correlation with neutrophils. Higher grade showed adverse histological parameters. %PSA was <25% in malignancy. ER positivity was noted in 80% malignant and 100% benign cases with weaker positivity noted maximum in benign cases. AR positivity was noted in all cases both benign and malignant, with benign cases showing higher intensity. Hormones play a multifactorial role in the pathogenesis of BPH and prostatic carcinoma; most commonly androgen and estrogen, and can be used towards finding a better therapy.
{"title":"Immunohistochemistry analysis of estrogen receptor and androgen receptor in benign prostatic hyperplasia and prostate carcinoma","authors":"Sneha Aditi, R. Naik","doi":"10.18231/j.jdpo.2022.052","DOIUrl":"https://doi.org/10.18231/j.jdpo.2022.052","url":null,"abstract":"Benign prostatic hyperplasia (BPH) and prostate adenocarcinoma are the most common disorders affecting elderly men. The diseases are androgen-dependent and are treated by obstructing androgen receptor (AR) or their action. AR has direct relationship between the development of prostatic hyperplasia and prostatic carcinoma. Estrogens directly target prostate tissue by definite estrogen receptors (ER). The human prostate is primed with a dual system of ERs (ER-α and ER-β). Use of estrogens as hormonal agents is for suppressing prostatic tissue growth. Study aims to identify, assess and establish the significance of ER and AR as a marker in distinguishing BPH and prostatic carcinoma. A cross sectional study was conducted at a tertiary care hospital over a period of two year on 65 specimens which included 30 malignant cases and 35 benign cases. Specimens received were tru-cut biopsy, transurethral resection of prostate chips (TURP) and prostatectomy specimen for malignant cases and TURP for benign lesions. Paraffin embedded blocks was stained with H&E and IHC with ER and AR performed on representative sections and graded .the results were assessed for association with various parameters in both benign and malignant cases. Out of 30 cases of adenocarcinoma of prostate majority of specimens were needle biopsies (54%). The age of presentation was 55-84 years with mean age being 68.93 years. In cases of BPH the presenting age was 35-84 years and mean age was 63 years. Histopathological parameters assessed for malignant lesions, showed negative correlation of grade group with PNI and positive correlation with neutrophils. Higher grade showed adverse histological parameters. %PSA was <25% in malignancy. ER positivity was noted in 80% malignant and 100% benign cases with weaker positivity noted maximum in benign cases. AR positivity was noted in all cases both benign and malignant, with benign cases showing higher intensity. Hormones play a multifactorial role in the pathogenesis of BPH and prostatic carcinoma; most commonly androgen and estrogen, and can be used towards finding a better therapy.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127608139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-15DOI: 10.18231/j.jdpo.2022.063
S. Zaheer, D. Aden, S. Ranga
A malignant intracerebral nerve sheath tumour (MINST) is a variant of MPNST arising inside the brain. They are very rare tumours that are aggressive and have strong metastatic potential. We report a case of a recurrent lesion in the brain in a 39 years male who presented as recurrent meningioma. It was finally reported as MINST with histopathology and immunohistochemistry. Surgical excision is the treatment of choice. The patient is on follow-up after an uneventful surgical excision. To the best of our knowledge, very few cases of malignant intracerebral nerve sheath tumours have been reported so far in the literature. This case is presented not only for its rarity but also to highlight that this aggressive tumour needs to be kept in mind while diagnosing such lesions with these histomorphological findings.
{"title":"Malignant intracerebral nerve sheath tumour of the brain presenting as a recurrent meningioma","authors":"S. Zaheer, D. Aden, S. Ranga","doi":"10.18231/j.jdpo.2022.063","DOIUrl":"https://doi.org/10.18231/j.jdpo.2022.063","url":null,"abstract":"A malignant intracerebral nerve sheath tumour (MINST) is a variant of MPNST arising inside the brain. They are very rare tumours that are aggressive and have strong metastatic potential. We report a case of a recurrent lesion in the brain in a 39 years male who presented as recurrent meningioma. It was finally reported as MINST with histopathology and immunohistochemistry. Surgical excision is the treatment of choice. The patient is on follow-up after an uneventful surgical excision. To the best of our knowledge, very few cases of malignant intracerebral nerve sheath tumours have been reported so far in the literature. This case is presented not only for its rarity but also to highlight that this aggressive tumour needs to be kept in mind while diagnosing such lesions with these histomorphological findings.","PeriodicalId":364340,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133267154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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