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Multifocal biliary carcinoma; whether synchronous or metastatic: A need to conquer 多灶性胆道癌;无论是同步的还是转移的:需要征服
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.027
Anju Shukla, Fatema Shareh Naqvi, Shashank Chaudhary
Multiple synchronous primary carcinoma involving gall bladder, liver and common bile duct are rare and difficult to differentiate with hepatic and extrahepatic bile duct metastasis from single primary. Radiological features, molecular landscape, and even integrated mutational profiling are not of much help. We describe a case of 48-year-old male who presented with jaundice and follow up CT scan raised the suspicion of gall bladder carcinoma with hepatic metastasis. Peroperative frozen section examination revealed adenocarcinoma with involvement of cystic duct margin; however revised common duct margin was free from tumor invasion. Final histopathology on resected gall bladder revealed multifocal adenocarcinoma, while histomorphology of hepatic nodule was consistent with cholangiocarcinoma. Common bile duct a one focus had also revealed adenocarcinoma while cut margins were negative form malignancy. In view of different morphology of gall bladder and hepatic tumor, no continuity of three tumors and single large, firm, non umblicated hepatic nodule, diagnosis of multiple synchronous carcinoma was suggested.
累及胆囊、肝脏及胆总管的多发原发癌较为罕见,且难以与单一原发癌的肝及肝外胆管转移相鉴别。放射学特征,分子景观,甚至综合突变谱都没有太大帮助。我们描述了一个48岁男性的病例,他表现为黄疸,随后的CT扫描提出了胆囊癌伴肝转移的怀疑。术中冰冻切片检查显示腺癌累及囊管边缘;而改良后的共管缘无肿瘤侵袭。切除胆囊的最终组织病理学显示为多灶性腺癌,而肝结节的组织形态学与胆管癌一致。一个病灶的胆总管也显示腺癌,而切缘为阴性。鉴于胆囊和肝脏肿瘤形态不同,三个肿瘤不连续性,单个大、硬、不重合的肝结节,建议诊断多发性同步癌。
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引用次数: 0
An unusually extensive orthokeratinized odontogenic cyst: A case report 异常广泛的形角化牙源性囊肿1例报告
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.026
S. Sachdev, Y. Adhane, M. A. Sardar, Priyanka Gajare, T. Chettiankandy
While odontogenic keratocysts (OKC) are fairly common and well-known, orthokeratinized odontogenic cysts (OOCs) are quite rare accounting for less than 1% of odontogenic cysts. The entity is characterized by the presence of a predominant orthokeratinized lining. OOC is much less aggressive as compared to OKC and simple enucleation is discerned as adequate treatment with minimal chances of recurrence. The present case report describes an extensive OOC that involved most of the angle and ramus of the mandible in a 25-year-old female.
虽然牙源性角化囊肿(OKC)是相当常见和众所周知的,但正角化牙源性囊肿(OOCs)相当罕见,占牙源性囊肿的不到1%。该实体的特征是存在一个主要的塑形角化衬里。与OKC相比,OOC的侵袭性要小得多,简单的去核被认为是一种足够的治疗方法,复发的可能性很小。本病例报告描述了一名25岁女性的广泛OOC,涉及下颌骨的大部分角度和分支。
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引用次数: 0
Breast hamartoma: A case series of 4 hamartoma cases including a rare myoid hamartoma of male breast 乳房错构瘤:报告4例错构瘤,包括一例罕见的男性乳房肌样错构瘤
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.028
D. Cherian, M. Siddiqui, S. Dhule, Piyush Prakash Narkhede, T. Fatima
Hamartomas by definition are masses of disorganised mature tissue indigenous to the particular site. They are seen in anatomical sites like skin, spleen and lungs where the latter is the most common site. Breast hamartomas are benign lesions not that commonly encountered in clinical practice. It is also synonymously known by other terms like adenolipoma. Terms like fibroadenolipoma and adenolipofibroma which were previously used are not recommended by the WHO. Hamartomas of the breast are composed of fibrous glandular or fat tissue. Breast hamartomas are rare in females and rarest in males. We report 4 cases of breast hamartomas one of which was myoid hamartoma in 38-year-old male and hamartoma with PASH (pseudoaangiomatous stromal hyperplasia) in a 32 year old female.
根据定义,错构瘤是特定部位固有的大量无组织的成熟组织。它们见于解剖部位,如皮肤、脾脏和肺部,后者是最常见的部位。乳腺错构瘤是临床上不常见的良性病变。它也与其他术语如腺脂肪瘤同义。像纤维腺脂肪瘤和腺脂肪纤维瘤这样的术语以前被世卫组织不推荐使用。乳房错构瘤由纤维腺体或脂肪组织组成。乳房错构瘤在女性和男性中都很少见。我们报告4例乳腺错构瘤,其中一例为肌样错构瘤,患者为38岁男性,另一例为错构瘤合并假血管瘤间质增生,患者为32岁女性。
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引用次数: 0
Gaucher’s disease is a common storage disorder but rare entity: Two case report 戈谢病是一种常见的存储障碍,但罕见的实体:2例报告
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.029
K. K. Verma, Nighat Hussain
Gaucher's disease is a rare, inherited autosomal recessive metabolic disorder due to deficiency of enzyme Glucocerebrosidase resulting in deposition of glucosylceramide. Deposition of glucosylceramide in different organs causes dysfunction and is responsible for specific systemic symptoms and signs. In the present cases, the first case was a 24-year-old female who presented with severe weakness with abdominal fullness due to massive splenomegaly. The unicity of the case was anti-nuclear antibody positivity. Although clinical signs and symptoms were classical in this case. The second case was a 20-year-old male who was already diagnosed case of Gaucher's disease but the only complaint was abdominal fullness due to massive splenomegaly. Special stains were play a tremendous role to highlighting Gaucher's cells.
戈谢病是一种罕见的遗传性常染色体隐性代谢性疾病,由于葡萄糖脑苷酶缺乏导致葡萄糖神经酰胺沉积。葡萄糖神经酰胺在不同器官的沉积导致功能障碍,并负责特定的全身症状和体征。在本病例中,第一位病例是一位24岁的女性,她因脾肿大而表现出严重的虚弱和腹部充盈。病例的独特性是抗核抗体阳性。虽然该病例的临床体征和症状是典型的。第二个病例是一名20岁的男性,他已经被诊断为戈谢病,但唯一的主诉是由于脾肿大引起的腹部充盈。特殊的染色剂在突出戈歇的细胞方面发挥了巨大的作用。
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引用次数: 0
Neurofibroma of Adrenal gland- A rare case report 肾上腺神经纤维瘤1例报告
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.022
Ankita N, Nagarekha K, M. Shanthi, Patil Shashirekha
Neurofibroma of the adrenal glands is rare, most common site of presentation are head and neck region and along the nerves. With the us of computed tomography , magnetic resonance imaging , an ultrasonography for the detection of adrenals masses is increasing. On computed tomography neurogenic tumours frequently appear as a distinct, smooth or lobulated mass. All varieties of neurogenic tumours may exhibit calcification But for confirmation of the lesion histopathological examination and immunohistochemistry is a must. Neurofibroma of adrenals although rare but a possibility. Immunohistochemistry plays an important role in confirming the diagnosis. IHC helps in definitive diagnosis which helps clinicians with management of the patient.
肾上腺神经纤维瘤是罕见的,最常见的表现部位是头颈部和沿神经。随着计算机断层扫描、磁共振成像、超声检查肾上腺肿块的应用越来越多。在计算机断层扫描上,神经源性肿瘤经常表现为明显的、光滑的或分叶状的肿块。所有类型的神经源性肿瘤均可出现钙化,但要确认病变必须进行组织病理学检查和免疫组织化学检查。肾上腺神经纤维瘤虽然罕见但也有可能。免疫组织化学在诊断中起重要作用。免疫健康检查有助于明确诊断,从而帮助临床医生对患者进行管理。
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引用次数: 0
A retrospective study on cervical cancer screening- In a newly opened tertiary care Centre in Eastern India 子宫颈癌筛查的回顾性研究-在印度东部新开设的三级保健中心
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.018
R. Saha, Deepika Pandey, S. Mondal, T. Santosh, Sujaya Mazumder, I. Chakrabarti
: One of the most prevalent cancers, cervical cancer is also the leading cause of mortality for women in underdeveloped nations. A fundamental test for finding infections and precancerous diseases is the Papanicolaou smear. This study aims to comprehend the function of cervical screening in detecting premalignant, malignant, and non-neoplastic lesions as well as the prevalence of different lesions in women who received a traditional pap smear technique. We screened women in the age group of 15-70 years who attended the Outpatient department of the Obstetrics and Gynaecology department of AIIMS, Kalyani. All women who gave consent for screening by Pap smear test were included. Of 2133 cases, most of the cases were benign comprising of Negative for Intraepithelial Lesion or malignancy (NILM) of about 1989 (93.24%) cases, 705 (33.05%) inflammatory. Atypical squamous cells of undetermined significance in 44 cases (2.06%), Atypical squamous cells cannot exclude HSIL in 3 (0.14%), low-grade squamous intraepithelial lesion (LSIL) in 11 (0.52%), high-grade squamous intraepithelial lesion (HSIL) in 5 (0.23%) women and Atypical glandular cell in 7 (0.33%). Out of 202 asymptomatic women (9.47%), 12 cases (0.56%) showed epithelial cell abnormality (8 ASCUS, 2 LSIL, 1 ASCH, 1HSIL) (Odds ratio=0.5056, Significance level, P=0.0362). Conventional Pap smear test is a very easy and cheap diagnostic tool to detect premalignant, malignant, and non-neoplastic lesions and the prevalence of various lesions.  As per the American Cancer Society (ACS), a pap smear should start from 25 years to be done till 65 years (repeated after every 3 years).
宫颈癌是最常见的癌症之一,也是不发达国家妇女死亡的主要原因。巴氏涂片检查是发现感染和癌前病变的一项基本检查。本研究旨在了解宫颈筛查在发现癌前病变、恶性病变和非肿瘤病变方面的作用,以及接受传统巴氏涂片技术的妇女中不同病变的患病率。我们筛选了在Kalyani AIIMS产科和妇科门诊就诊的15-70岁年龄组的妇女。所有同意接受巴氏涂片检查的妇女都包括在内。2133例中绝大多数为良性,其中上皮内病变阴性或恶性(NILM)约1989例(93.24%),炎性705例(33.05%)。非典型鳞状细胞44例(2.06%),不典型鳞状细胞不能排除HSIL 3例(0.14%),低级别鳞状上皮内病变(LSIL) 11例(0.52%),高级别鳞状上皮内病变(HSIL) 5例(0.23%),非典型腺细胞7例(0.33%)。202例无症状女性(9.47%)中,上皮细胞异常12例(0.56%)(ASCUS 8例,LSIL 2例,ASCH 1例,hsil 1例)(优势比=0.5056,显著性水平,P=0.0362)。传统的巴氏涂片检查是一种非常简单和廉价的诊断工具,可以检测癌前、恶性和非肿瘤病变以及各种病变的患病率。根据美国癌症协会(ACS)的规定,子宫颈抹片检查应从25岁开始,直到65岁(每3年重复一次)。
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引用次数: 0
Appendiceal collision tumor presented as acute appendicitis: A dissonant scenario 阑尾碰撞肿瘤表现为急性阑尾炎:一个不和谐的场景
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.020
Sushma Prasanthi Nagireddi, R. Shetty, Athira K P, Madhukar Devadiga, K. Vaidya
Renal cell carcinoma arises from the epithelium of the renal tubules and accounts for approximately 3% of adult malignancies. Tumours occur most often in older individuals usually in sixth and seventh decades of life. Bilateral multifocal papillary type of RCC is rare and its presence should prompt the suspicion of some underlying hereditary genetic predisposition thus thorough cytogenetic evaluation and detailed family history could help in finding the etiology. Bilateral RCC could be synchronous or metachronous. We hereby present the autopsy findings of a case of sudden death of a 65 years old male. On histopathological evaluation, both kidneys showed papillary variant of renal cell carcinoma as an incidental finding.
肾细胞癌起源于肾小管上皮,约占成人恶性肿瘤的3%。肿瘤最常发生在老年人身上,通常发生在六、七十岁。双侧多灶乳头状肾细胞癌是罕见的,它的存在应该提示一些潜在的遗传易感性的怀疑,因此彻底的细胞遗传学评估和详细的家族史可以帮助找到病因。双侧RCC可以是同步的,也可以是同步的。我们在此报告一名65岁男性猝死病例的尸检结果。在组织病理学评估,两个肾脏显示乳头状变异型肾细胞癌作为一个偶然发现。
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引用次数: 0
Metaplastic squamous cell carcinoma caricaturing as tuberculous mastitis-A vicissitude of clinical diagnostic misadventure 被讽刺为结核性乳腺炎的化生性鳞状细胞癌——临床诊断失误的变迁
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.021
K. Pardeshi, Hoogar Mallinath Basalingappa, Sameer Kadam, Nakul Y. Sampat, Vaishali Bhonsle, Arvind Govind Valand
Tuberculous mastitis and invasive breast cancers are known to co-exist or occur in the breast independently of each other, albeit the former being less common in developed countries. Tuberculous mastitis with its clinical presentation and morphological features can caricature invasive breast carcinoma. The overlapping features of tuberculous mastitis and metaplastic squamous cell carcinoma often lead to, if no due clinical diligence and discretion is used, bewildering misinterpretation with the vicissitude of diagnostic implications of tuberculous mastitis ensuing catastrophic and perilous ramifications. A 42-year-old woman presented with exophytic growth with extensive areas of ulceration. Clinically, the lesion was diagnosed as disseminated tuberculous mastitis based on clinical and morphological features, which was surgically resected. On histological examination, the lesion was diagnosed as invasive metaplastic squamous cell carcinoma. Thecase being presented here displays the vagary involved in clinical diagnosis of tuberculous mastitis inasmuch as it often shares clinical and morphological features with a devastatingly perilous variant of invasive duct carcinoma, metaplastic squamous cell carcinoma, the inadvertent eschewing of or misapprehending of which may engender devastating prognostic implications.
众所周知,结核性乳腺炎和浸润性乳腺癌在乳房中共存或独立发生,尽管前者在发达国家不太常见。结核性乳腺炎的临床表现和形态学特征可以讽刺浸润性乳腺癌。结核性乳腺炎和化脓性鳞状细胞癌的重叠特征经常导致,如果没有适当的临床调查和谨慎使用,令人困惑的误解与结核性乳腺炎的诊断意义的变化,随之而来的是灾难性和危险的后果。42岁女性,外生性生长伴大面积溃疡。临床结合临床及形态学特征诊断为弥散性结核性乳腺炎,行手术切除。经组织学检查,诊断为浸润性化生鳞状细胞癌。本病例显示了结核性乳腺炎临床诊断的不确定性,因为它通常与侵袭性导管癌、化生性鳞状细胞癌具有相同的临床和形态学特征,对其的疏忽回避或误解可能会导致毁灭性的预后影响。
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引用次数: 0
Bilateral multifocal papillary renal cell carcinoma on autopsy: A case report 双侧多灶性乳头状肾细胞癌尸检报告1例
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.019
Monika Yadav, R. Agarwal, Kulwant Singh, Yogesh Kumar, Bharat B Sidana
Renal cell carcinoma arises from the epithelium of the renal tubules and accounts for approximately 3% of adult malignancies. Tumours occur most often in older individuals usually in sixth and seventh decades of life. Bilateral multifocal papillary type of RCC is rare and its presence should prompt the suspicion of some underlying hereditary genetic predisposition thus thorough cytogenetic evaluation and detailed family history could help in finding the etiology. Bilateral RCC could be synchronous or metachronous. We hereby present the autopsy findings of a case of sudden death of a 65 years old male. On histopathological evaluation, both kidneys showed papillary variant of renal cell carcinoma as an incidental finding.
肾细胞癌起源于肾小管上皮,约占成人恶性肿瘤的3%。肿瘤最常发生在老年人身上,通常发生在六、七十岁。双侧多灶乳头状肾细胞癌是罕见的,它的存在应该提示一些潜在的遗传易感性的怀疑,因此彻底的细胞遗传学评估和详细的家族史可以帮助找到病因。双侧RCC可以是同步的,也可以是同步的。我们在此报告一名65岁男性猝死病例的尸检结果。在组织病理学评估,两个肾脏显示乳头状变异型肾细胞癌作为一个偶然发现。
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引用次数: 0
An incidental finding of microfilaria on a urine cytological smear study 尿细胞学涂片检查偶然发现微丝蚴
Pub Date : 2023-06-15 DOI: 10.18231/j.jdpo.2023.025
Patel Keval A, Parmar Riddhi A
In developing nations, lymphatic filariasis is a significant public health concern. Wuchereria bancrofti species, which are morphologically recognised as sheathed parasites with a tail tip free of nuclei, are responsible for almost 90% of the cases in India. Microfilariae have been found in a wide range of other body fluids as well as urine samples from patients with chylous and achylous hematuria. We report a case of microfilariasis in urine cytology. This study aims to raise awareness of the possibility of filariasis in bodily fluids and aspirates, particularly in areas where it is endemic. Identification results in a comprehensive diagnostic and treatment plan for the patient.
在发展中国家,淋巴丝虫病是一个重大的公共卫生问题。在形态学上被认为是一种有鞘的寄生虫,尾巴尖端没有细胞核,印度90%的病例都是这种寄生虫造成的。在乳糜和无乳性血尿患者的多种其他体液以及尿液样本中都发现了微丝蚴。我们报告一例尿细胞学中的微丝虫病。这项研究的目的是提高人们对体液和吸入物中存在丝虫病可能性的认识,特别是在流行丝虫病的地区。识别结果为患者提供全面的诊断和治疗计划。
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引用次数: 0
期刊
IP Journal of Diagnostic Pathology and Oncology
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