Health Science Reports最新文献_第9页

Prevalence of Intestinal Parasites and Associated Factors Among Public Primary Second-Cycle Schoolchildren in Debre Markos Town, Northwest Ethiopia: A Cross-Sectional Study 埃塞俄比亚西北部 Debre Markos 镇公立小学第二周期学童肠道寄生虫流行率及相关因素：一项横断面研究。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-13 DOI: 10.1002/hsr2.70339

Abtie Abebaw, Gebreselassie Demeke, Hylemariam Mihiretie Mengist, Mengistu Endalamaw, Gizew Damtie Demeke

Background and Aims

Intestinal parasitic infection is a common disease that causes significant morbidity and mortality in developing countries, including Ethiopia. The burden of intestinal parasites is worse in schoolchildren, which leads to absenteeism from school, lower cognitive ability, affects academic performance, and causes malnutrition and anemia. While many studies have been reported, there is a paucity of published data in Debre Markos. Therefore, this study aimed to assess the prevalence of intestinal parasites and associated factors among public primary second-cycle schoolchildren in Debre Markos Town, Northwest Ethiopia.

Methods

A school-based cross-sectional study was conducted among three selected public primary second-cycle schools in Debre Markos town from May 1 to 30, 2022. Study participants were selected by using random and systematic sampling techniques with proportional allocation to each grade. Data were collected using semi-structured questionnaires. A single stool specimen was collected from the study participants and processed using direct wet mount and formol ether concentration technique. Binary logistic regression models were applied to assess the association between independent and outcome variables at a 95% confidence level.

Results

A total of 343 students were included in the study. The overall prevalence of intestinal parasites was 12% (41/343) with a predominance of hookworms (5.2%, 18/343), followed by Ascaris lumbricoides 2.3% (8/343), Entamoeba histolytica/dispar 1.2% (4/343), Hymenolepis nana 0.9% (3/343), Strongyloides stercoralis 0.9% (3/343), Giardia lamblia 0.9% (3/343), and Trichuris trichiura 0.6% (2/343). The habit of open-field defecation (AOR, 95% CI; 2.43 [1.16–5.09]), not using soap to wash hands (AOR, 95% CI; 2.93 [1.33–6.42]), and not wearing closed shoes (AOR, 95% CI; 3.12 [1.19–8.23]) were factors significantly associated with the prevalence of intestinal parasitic infection.

Conclusion

The prevalence of intestinal parasites was comparatively low in the study area. Open-field defecation, not using soap to wash hands, and not wearing closed shoes were identified as independent predictors.

背景和目的：肠道寄生虫感染是一种常见病，在包括埃塞俄比亚在内的发展中国家引起严重的发病率和死亡率。肠道寄生虫的负担在学龄儿童中更为严重，导致缺课、认知能力下降、影响学习成绩，并导致营养不良和贫血。虽然有许多研究报告，但在德布雷马科斯发表的数据很少。因此，本研究旨在评估埃塞俄比亚西北部Debre Markos镇公立小学二周期学生肠道寄生虫的患病率及其相关因素。方法：于2022年5月1日至30日在Debre Markos镇选定的三所公立小学二周期学校进行了以学校为基础的横断面研究。研究参与者采用随机和系统抽样技术，按比例分配到每个年级。数据采用半结构化问卷收集。从研究参与者中收集了一份粪便标本，并使用直接湿装和福尔摩醚浓缩技术进行处理。采用二元logistic回归模型评估自变量和结果变量之间的相关性，置信度为95%。结果：共纳入343名学生。肠道寄生虫总体检出率为12%(41/343)，以钩虫为优势（5.2%,18/343），其次为类蚓蛔虫2.3%（8/343）、溶组织内阿米巴1.2%（4/343）、小膜膜绦虫0.9%（3/343）、粪线虫0.9%（3/343）、兰第鞭毛虫0.9%（3/343）、毛滴虫0.6%（2/343）。露天排便习惯(AOR, 95% CI；2.43[1.16-5.09])，不使用肥皂洗手(AOR, 95% CI；2.93[1.33-6.42])，未穿闭合鞋(AOR, 95% CI；3.12[1.19-8.23])是与肠道寄生虫感染患病率显著相关的因素。结论：研究区肠道寄生虫患病率较低。露天排便、不使用肥皂洗手和不穿封闭鞋被认为是独立的预测因素。

{"title":"Prevalence of Intestinal Parasites and Associated Factors Among Public Primary Second-Cycle Schoolchildren in Debre Markos Town, Northwest Ethiopia: A Cross-Sectional Study","authors":"Abtie Abebaw, Gebreselassie Demeke, Hylemariam Mihiretie Mengist, Mengistu Endalamaw, Gizew Damtie Demeke","doi":"10.1002/hsr2.70339","DOIUrl":"10.1002/hsr2.70339","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Intestinal parasitic infection is a common disease that causes significant morbidity and mortality in developing countries, including Ethiopia. The burden of intestinal parasites is worse in schoolchildren, which leads to absenteeism from school, lower cognitive ability, affects academic performance, and causes malnutrition and anemia. While many studies have been reported, there is a paucity of published data in Debre Markos. Therefore, this study aimed to assess the prevalence of intestinal parasites and associated factors among public primary second-cycle schoolchildren in Debre Markos Town, Northwest Ethiopia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A school-based cross-sectional study was conducted among three selected public primary second-cycle schools in Debre Markos town from May 1 to 30, 2022. Study participants were selected by using random and systematic sampling techniques with proportional allocation to each grade. Data were collected using semi-structured questionnaires. A single stool specimen was collected from the study participants and processed using direct wet mount and formol ether concentration technique. Binary logistic regression models were applied to assess the association between independent and outcome variables at a 95% confidence level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 343 students were included in the study. The overall prevalence of intestinal parasites was 12% (41/343) with a predominance of hookworms (5.2%, 18/343), followed by <i>Ascaris lumbricoides</i> 2.3% (8/343), <i>Entamoeba histolytica/dispar</i> 1.2% (4/343), <i>Hymenolepis nana</i> 0.9% (3/343), <i>Strongyloides stercoralis</i> 0.9% (3/343), G<i>iardia lamblia</i> 0.9% (3/343), and <i>Trichuris trichiura</i> 0.6% (2/343). The habit of open-field defecation (AOR, 95% CI; 2.43 [1.16–5.09]), not using soap to wash hands (AOR, 95% CI; 2.93 [1.33–6.42]), and not wearing closed shoes (AOR, 95% CI; 3.12 [1.19–8.23]) were factors significantly associated with the prevalence of intestinal parasitic infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The prevalence of intestinal parasites was comparatively low in the study area. Open-field defecation, not using soap to wash hands, and not wearing closed shoes were identified as independent predictors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Value of Fine Needle Aspiration Cytology and Cell Morphology in Determining the Histogenesis of Pancreatic Lesions With Review of Literature, Overview and Cytological Experience of 25 Years: Original Research 细针穿刺细胞学和细胞形态学在确定胰腺病变组织发生中的价值——文献回顾、综述和25年细胞学经验：原创性研究。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-12 DOI: 10.1002/hsr2.70347

Soudah Bisharah, Abbas Mahmoud

Background and Aims

Benign lesions, inflammation, cysts and pseudocysts, as well as neoplasms of the exocrine and endocrine parts of the pancreas can be easily identified using cytological methods. The sensitivity and specificity can be increased with the help of additional examination methods. The sensitivity of intraoperative rapid cytology reaches about 99%. In the literature, the sensitivity reaches an average of about 85% for biopsies. The method is easy to use, has very low complication rates (1%–2%) and is safe for the patient.

Methods

1290 cytological samples from pancreatic lesions were processed in the institute of pathology at Hannover Medical School (MHH), as cytological smears and stained with Giemsa and PAS stains as conventional methods. They were compared with the histological specimens that were processed at the same institute. Immunocytochemistry and molecularpathology have been processed only in selected cases. In general, it is routine in the university that the patients give their written consent to participate in clinical studies. The local ethics committee has stated that there is no need for approval due to the retrospective nature of the study.

Results

In this work, we detected 20.077% malignant lesions, 63.333% benign findings and inflammation, 7.441% pseudocysts and cysts. About 9.147% samples were unrepresentative due to insufficient number of cells.

Conclusion

This work will highlight the importance of fine aspiration cytology (FNAC) of suspicious pancreatic lesions, its possibilities and limitations in routine diagnostics with discussing the differential diagnoses, pointing to its great value and safety for patients. FNAC is the gold standard, its power is strongly associated with high specificity and sensitivity in the diagnosis of pancreatic lesions, and is very useful in the differential diagnosis between malignant and inflammatory lesions in pancreas.

背景和目的：胰腺的良性病变、炎症、囊肿和假性囊肿以及胰腺外分泌和内分泌部位的肿瘤可以很容易地用细胞学方法识别。在其他检查方法的帮助下，灵敏度和特异性可以提高。术中快速细胞学检查灵敏度可达99%左右。在文献中，活检的灵敏度平均达到85%左右。该方法使用方便，并发症发生率极低（1%-2%），对患者安全。方法：在汉诺威医学院病理研究所对1290例胰腺病变细胞学标本进行细胞学涂片处理，常规方法采用Giemsa染色和PAS染色。将它们与同一研究所处理的组织学标本进行比较。免疫细胞化学和分子病理学仅在选定的病例中进行了处理。一般来说，在大学里，病人必须书面同意参加临床研究。当地伦理委员会已经声明，由于该研究的回顾性性质，不需要批准。结果：恶性病变检出率为20.077%，良性及炎症检出率为63.333%，假性囊肿及囊肿检出率为7.441%。约9.147%的样本因细胞数量不足而不具代表性。结论：本工作将强调细吸细胞学（FNAC）在可疑胰腺病变中的重要性，其在常规诊断中的可能性和局限性，并讨论其鉴别诊断，指出其对患者的巨大价值和安全性。FNAC是诊断胰腺病变的金标准，其功能与诊断胰腺病变的高特异性和敏感性密切相关，在胰腺恶性病变和炎性病变的鉴别诊断中非常有用。

{"title":"Evaluation of the Value of Fine Needle Aspiration Cytology and Cell Morphology in Determining the Histogenesis of Pancreatic Lesions With Review of Literature, Overview and Cytological Experience of 25 Years: Original Research","authors":"Soudah Bisharah, Abbas Mahmoud","doi":"10.1002/hsr2.70347","DOIUrl":"10.1002/hsr2.70347","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Benign lesions, inflammation, cysts and pseudocysts, as well as neoplasms of the exocrine and endocrine parts of the pancreas can be easily identified using cytological methods. The sensitivity and specificity can be increased with the help of additional examination methods. The sensitivity of intraoperative rapid cytology reaches about 99%. In the literature, the sensitivity reaches an average of about 85% for biopsies. The method is easy to use, has very low complication rates (1%–2%) and is safe for the patient.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>1290 cytological samples from pancreatic lesions were processed in the institute of pathology at Hannover Medical School (MHH), as cytological smears and stained with Giemsa and PAS stains as conventional methods. They were compared with the histological specimens that were processed at the same institute. Immunocytochemistry and molecularpathology have been processed only in selected cases. In general, it is routine in the university that the patients give their written consent to participate in clinical studies. The local ethics committee has stated that there is no need for approval due to the retrospective nature of the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this work, we detected 20.077% malignant lesions, 63.333% benign findings and inflammation, 7.441% pseudocysts and cysts. About 9.147% samples were unrepresentative due to insufficient number of cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This work will highlight the importance of fine aspiration cytology (FNAC) of suspicious pancreatic lesions, its possibilities and limitations in routine diagnostics with discussing the differential diagnoses, pointing to its great value and safety for patients. FNAC is the gold standard, its power is strongly associated with high specificity and sensitivity in the diagnosis of pancreatic lesions, and is very useful in the differential diagnosis between malignant and inflammatory lesions in pancreas.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological Soft Signs in Type I Bipolar Disorder and Bipolar Spectrum Patients and Their Unaffected First-Degree Relatives: A Cross-Sectional Study I型双相情感障碍和双相情感谱系患者及其未受影响的一级亲属的神经系统软症状：一项横断面研究。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-12 DOI: 10.1002/hsr2.70341

Seyed Saeed Sadr, Seyed Mehdi Samimi-Ardestani, Yousef Semnani, Narges Adel, Faezeh Tajari, Nastaran Samani

Background and Aims

This study aimed to compare neurological soft signs (NSSs) in type 1 bipolar disorder (BD), bipolar spectrum (BS) patients, and their unaffected first-degree relatives.

Methods

This descriptive cross-sectional study involved participants referred to the Psychiatric Department of Imam Hossein Hospital. Five groups (n = 25): patients with type 1 BD, patients with BS, unaffected first-degree relatives of the two groups, and a control group were evaluated using the Neurological Evaluation Scale (NES).

Results

The analysis revealed that patients with bipolar I disorder had the highest NES scores, with significant group differences (F(4.120) = 10.36, p < 0.001). The Bonferroni correction identified bipolar I patients as the primary source of this difference, while other groups did not significantly differ. ANCOVA showed that age (F(1.123) = 3.92, p = 0.052) and gender (F(1.123) = 0.1, p = 0.75) had no significant influence on NES scores. However, all four NES subsets significantly contributed to the overall score, except for the sensory subset. Differences were significant between bipolar I patients and most other groups, except the BS group, which showed no significant differences from the rest. No correlation was found with age, gender, or age of disease onset.

Conclusion

The higher NSS severity in type I BD compared to BS and control groups highlights its potential link to the genetic and neurodevelopmental differences in BD type I. Further research is recommended.

背景与目的：本研究旨在比较1型双相情感障碍（BD）、双相情感谱系（BS）患者及其未受影响的一级亲属的神经系统软体征（nss）。方法：这项描述性横断面研究涉及到伊玛目侯赛因医院精神科的参与者。采用神经学评估量表（NES）对1型BD患者、BS患者、两组未受影响的一级亲属和对照组进行评估，共5组（n = 25）。结果：分析显示双相I型障碍患者的NES评分最高，组间差异有统计学意义(F(4.120) = 10.36, p (1.123) = 3.92, p = 0.052)，性别（F(1.123) = 0.1, p = 0.75）对NES评分无显著影响。然而，除了感觉子集外，所有四个NES子集都对总分有显著贡献。双相I型患者与大多数其他组之间存在显著差异，但BS组与其他组无显著差异。未发现与年龄、性别或发病年龄相关。结论：与BS组和对照组相比，I型BD患者NSS严重程度较高，这表明其可能与I型BD的遗传和神经发育差异有关。

{"title":"Neurological Soft Signs in Type I Bipolar Disorder and Bipolar Spectrum Patients and Their Unaffected First-Degree Relatives: A Cross-Sectional Study","authors":"Seyed Saeed Sadr, Seyed Mehdi Samimi-Ardestani, Yousef Semnani, Narges Adel, Faezeh Tajari, Nastaran Samani","doi":"10.1002/hsr2.70341","DOIUrl":"10.1002/hsr2.70341","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>This study aimed to compare neurological soft signs (NSSs) in type 1 bipolar disorder (BD), bipolar spectrum (BS) patients, and their unaffected first-degree relatives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This descriptive cross-sectional study involved participants referred to the Psychiatric Department of Imam Hossein Hospital. Five groups (<i>n</i> = 25): patients with type 1 BD, patients with BS, unaffected first-degree relatives of the two groups, and a control group were evaluated using the Neurological Evaluation Scale (NES).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis revealed that patients with bipolar I disorder had the highest NES scores, with significant group differences (<i>F</i>(4.120) = 10.36, <i>p</i> < 0.001). The Bonferroni correction identified bipolar I patients as the primary source of this difference, while other groups did not significantly differ. ANCOVA showed that age (<i>F</i>(1.123) = 3.92, <i>p</i> = 0.052) and gender (<i>F</i>(1.123) = 0.1, <i>p</i> = 0.75) had no significant influence on NES scores. However, all four NES subsets significantly contributed to the overall score, except for the sensory subset. Differences were significant between bipolar I patients and most other groups, except the BS group, which showed no significant differences from the rest. No correlation was found with age, gender, or age of disease onset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The higher NSS severity in type I BD compared to BS and control groups highlights its potential link to the genetic and neurodevelopmental differences in BD type I. Further research is recommended.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on the Role of Human Solute Carriers Transporters in Cancer 人类溶质载体转运体在癌症中的作用综述。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-12 DOI: 10.1002/hsr2.70343

Md. Shafiul Hossen, Mohammed Shafin Ul Islam, Mohammad Yasin, Mohammed Ibrahim, Abhijit Das

Background and Aim

The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable of transporting different amino acids, cancer may develop as a result of these transporters' over-expression due to their complex formation with other biological molecules. Therefore, this review investigated the role of SLC transporters in the progression of cancer.

Methods

We retrieved data from Google Scholar, Web of Science, PubMed, Cochrane Library, and EMBASE regarding the influence of human SLCs on the development of cancer. Articles published in English before August 2024 were included in the study.

Results

The overexpression of SLCs is strongly related to tumor cell proliferation and angiogenesis in a number of cancer types including thyroid, pancreatic, lung, hepatocellular, and colon cancers. They are crucial for the stimulation of several biological signaling pathways, particularly mTOR kinase activity, which starts a signaling cascade, protein synthesis, cell growth, and proliferation, and inhibits apoptosis of cancerous cells. Furthermore, they contribute to the activation of PI3K/AKT signaling, which has an impact on the growth, invasion, and death of cancer cells. Thus, SLC transporters become a potential therapeutic target that plays a crucial role in drug resistance, tumor microenvironment regulation, and modulation of immune response.

Conclusion

The review recognized the crucial role of SLC transporters in different types of cancer progression. Therefore, to confirm our findings, a case-control study is required to investigate the role of amino acid transporters in cancer development.

背景与目的：肿瘤的高速生长导致对氨基酸的需求增加。由于溶质载体（SLC）转运蛋白能够转运不同的氨基酸，这些转运蛋白与其他生物分子形成复合物而过度表达可能导致癌症的发生。因此，本文综述了SLC转运蛋白在癌症进展中的作用。方法：我们从谷歌Scholar、Web of Science、PubMed、Cochrane Library和EMBASE检索有关人类SLCs对癌症发展的影响的数据。研究纳入了2024年8月之前发表的英文文章。结果：SLCs的过表达与甲状腺、胰腺癌、肺癌、肝细胞癌和结肠癌等多种癌症的肿瘤细胞增殖和血管生成密切相关。它们对于刺激几种生物信号通路至关重要，特别是mTOR激酶活性，它启动信号级联，蛋白质合成，细胞生长和增殖，并抑制癌细胞凋亡。此外，它们有助于激活PI3K/AKT信号，从而影响癌细胞的生长、侵袭和死亡。因此，SLC转运体成为一个潜在的治疗靶点，在耐药、肿瘤微环境调节和免疫反应调节中起着至关重要的作用。结论：本综述确认了SLC转运蛋白在不同类型癌症进展中的关键作用。因此，为了证实我们的发现，需要一项病例对照研究来调查氨基酸转运蛋白在癌症发展中的作用。

{"title":"A Review on the Role of Human Solute Carriers Transporters in Cancer","authors":"Md. Shafiul Hossen, Mohammed Shafin Ul Islam, Mohammad Yasin, Mohammed Ibrahim, Abhijit Das","doi":"10.1002/hsr2.70343","DOIUrl":"10.1002/hsr2.70343","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable of transporting different amino acids, cancer may develop as a result of these transporters' over-expression due to their complex formation with other biological molecules. Therefore, this review investigated the role of SLC transporters in the progression of cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrieved data from Google Scholar, Web of Science, PubMed, Cochrane Library, and EMBASE regarding the influence of human SLCs on the development of cancer. Articles published in English before August 2024 were included in the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overexpression of SLCs is strongly related to tumor cell proliferation and angiogenesis in a number of cancer types including thyroid, pancreatic, lung, hepatocellular, and colon cancers. They are crucial for the stimulation of several biological signaling pathways, particularly mTOR kinase activity, which starts a signaling cascade, protein synthesis, cell growth, and proliferation, and inhibits apoptosis of cancerous cells. Furthermore, they contribute to the activation of PI3K/AKT signaling, which has an impact on the growth, invasion, and death of cancer cells. Thus, SLC transporters become a potential therapeutic target that plays a crucial role in drug resistance, tumor microenvironment regulation, and modulation of immune response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The review recognized the crucial role of SLC transporters in different types of cancer progression. Therefore, to confirm our findings, a case-control study is required to investigate the role of amino acid transporters in cancer development.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing Healthcare Complaints Analysis Tool for Health System: A Cross-Sectional Study 发展卫生系统医疗投诉分析工具：一项横断面研究。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-12 DOI: 10.1002/hsr2.70325

Ali Vafaee Najar, Damoon Gorji, Hoorang Nazari Ardabili, Maryam Pourshirazi, Elaheh Houshmand

Background and Aims

The role of the healthcare system in the provision, maintenance, and promotion of public health is associated with handling healthcare complaints. This notion as the principle of accountability requires the authorities' attention. This study aimed to develop the Healthcare Complaints Analysis Tool (HCAT) in Iran.

Methods

Following a comprehensive review of the country and field studies conducted in the Medical System Organization and Universities of Medical Sciences, the features of patients' complaints were extracted from medical centers and hospitals. Then, experts who were experienced in health and medical areas localized HCAT through translation and re-translation process using the Delphi technique. Finally, the healthcare complaints were classified according to the localized HCAT components.

Result

Using HCAT showed that in Iran's healthcare system, complaints were related to relative frequency and percentage of all types of complaints. However, there is a lack of a mechanized registration system, investigation, analysis, and classification of healthcare complaints.

Conclusions

Providing medical centers with such a system by the ministry of health and mandatory reporting of complaints may lead to coding complaints, measure the severity of complaints, service monitoring and organizational learning.

背景和目的：医疗保健系统在提供、维护和促进公众健康方面的作用与处理医疗投诉有关。作为问责原则的这一概念需要引起当局的注意。本研究旨在发展伊朗医疗保健投诉分析工具（HCAT）。方法：通过对医疗系统组织和医学大学进行的国家和实地研究的综合回顾，提取医疗中心和医院的患者投诉特征。然后，在卫生和医疗领域经验丰富的专家通过德尔福技术的翻译和再翻译过程对HCAT进行本地化。最后，根据局部HCAT成分对医疗投诉进行分类。结果：HCAT显示，在伊朗的医疗保健系统中，投诉与各类投诉的相对频率和百分比有关。然而，缺乏医疗投诉的机械化登记系统、调查、分析和分类。结论：卫生部为医疗中心提供此类系统，并强制报告投诉，可实现投诉编码、投诉严重程度衡量、服务监控和组织学习。

{"title":"Developing Healthcare Complaints Analysis Tool for Health System: A Cross-Sectional Study","authors":"Ali Vafaee Najar, Damoon Gorji, Hoorang Nazari Ardabili, Maryam Pourshirazi, Elaheh Houshmand","doi":"10.1002/hsr2.70325","DOIUrl":"10.1002/hsr2.70325","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>The role of the healthcare system in the provision, maintenance, and promotion of public health is associated with handling healthcare complaints. This notion as the principle of accountability requires the authorities' attention. This study aimed to develop the Healthcare Complaints Analysis Tool (HCAT) in Iran.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following a comprehensive review of the country and field studies conducted in the Medical System Organization and Universities of Medical Sciences, the features of patients' complaints were extracted from medical centers and hospitals. Then, experts who were experienced in health and medical areas localized HCAT through translation and re-translation process using the Delphi technique. Finally, the healthcare complaints were classified according to the localized HCAT components.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Using HCAT showed that in Iran's healthcare system, complaints were related to relative frequency and percentage of all types of complaints. However, there is a lack of a mechanized registration system, investigation, analysis, and classification of healthcare complaints.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Providing medical centers with such a system by the ministry of health and mandatory reporting of complaints may lead to coding complaints, measure the severity of complaints, service monitoring and organizational learning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross-Sectional Study 评估亚甲基四氢叶酸还原酶（Rs1801131 和 Rs1801133）基因多态性与 STEMI 和 NSTEMI 患者冠状动脉病变严重程度的关系：一项回顾性横断面研究。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-12 DOI: 10.1002/hsr2.70284

Behnam Nazarzadeh, Saeedeh sadat Ghazanfari, Farzaneh Karimi, Seyed ali Moezibady, Fatemeh Salmani, Kazem Dastjerdi, Hamidreza Mohammadi

Background and Aims

Mounting evidence have implicated that rs1801131 and rs1801133, located in the Methylenetetrahydrofolate reductase (MTHFR) gene, may emerge as novel biomarkers for coronary artery disease (CAD). The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score is also an appropriate predictor for revascularization strategy in patients with complex CAD. The aim of this study is to investigate the correlation between rs1801131 and rs1801133 with the severity of coronary lesions in patients with ST‑Elevation Myocardial Infarction (STEMI) and Non‑ST‑Elevation Myocardial Infarction (NSTEMI) based on the SYNTAX score.

Methods

This retrospective cross-sectional study included 96 patients diagnosed with STEMI and NSTEMI from Razi University Hospital between April and September 2019. Ninety-six patients were diagnosed with STEMI (N = 43) and NSTEMI (N = 53) were recruited from South Khorasan, Iran. The angiographical characteristics of CAD were defined by the SYNTAX score. Genomic DNA was isolated from peripheral blood and genotyped for rs1801131 and rs1801133 using the TaqMan real-time PCR method.

Results

The results of the one-way analysis of variance indicated that there is no association between rs1801131 and rs1801133 with the severity of coronary lesions in patients with STEMI (p = 0.44) and NSTEMI (p = 0.91). However, the two-way analysis of variance comparison and post-hoc test demonstrated that rs1801133 in the presence of rs1801131 is correlated with the SYNTAX score in NSTEMI (p = 0.03) and total patients (p = 0.03).

Conclusion

In conclusion, our study reveals a significant association between the MTHFR polymorphism rs1801133 and CAD severity, particularly in NSTEMI patients. While rs1801131 showed no correlation, rs1801133 may serve as a valuable genetic biomarker for assessing CAD severity. Further research with larger populations is needed to confirm these findings.

背景和目的：越来越多的证据表明，位于亚甲基四氢叶酸还原酶（MTHFR）基因中的rs1801131和rs1801133可能成为冠状动脉疾病（CAD）的新型生物标志物。经皮冠状动脉介入治疗与心脏手术（SYNTAX）评分之间的协同作用也是复杂CAD患者血运重建策略的适当预测指标。本研究的目的是基于SYNTAX评分，探讨rs1801131和rs1801133与ST段抬高型心肌梗死（STEMI）和非ST段抬高型心肌梗死（NSTEMI）患者冠脉病变严重程度的相关性。方法：本回顾性横断面研究纳入了2019年4月至9月在拉兹大学医院诊断为STEMI和NSTEMI的96例患者。从伊朗南呼罗珊招募了96例被诊断为STEMI （N = 43）和NSTEMI （N = 53）的患者。CAD的血管造影特征由SYNTAX评分定义。从外周血中分离基因组DNA，采用TaqMan实时PCR法对rs1801131和rs1801133进行基因分型。结果：单因素方差分析结果显示，rs1801131和rs1801133与STEMI患者冠状动脉病变严重程度无相关性（p = 0.44）和NSTEMI患者无相关性（p = 0.91）。然而，方差比较和事后检验的双向分析表明，rs1801131存在的rs1801133与NSTEMI患者的SYNTAX评分（p = 0.03）和总患者的SYNTAX评分（p = 0.03）相关。结论：总之，我们的研究揭示了MTHFR多态性rs1801133与CAD严重程度之间的显著相关性，特别是在NSTEMI患者中。虽然rs1801131没有相关性，但rs1801133可能作为评估CAD严重程度的有价值的遗传生物标志物。需要对更大的人群进行进一步的研究来证实这些发现。

{"title":"Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross-Sectional Study","authors":"Behnam Nazarzadeh, Saeedeh sadat Ghazanfari, Farzaneh Karimi, Seyed ali Moezibady, Fatemeh Salmani, Kazem Dastjerdi, Hamidreza Mohammadi","doi":"10.1002/hsr2.70284","DOIUrl":"10.1002/hsr2.70284","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Mounting evidence have implicated that rs1801131 and rs1801133, located in the Methylenetetrahydrofolate reductase (MTHFR) gene, may emerge as novel biomarkers for coronary artery disease (CAD). The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score is also an appropriate predictor for revascularization strategy in patients with complex CAD. The aim of this study is to investigate the correlation between rs1801131 and rs1801133 with the severity of coronary lesions in patients with ST‑Elevation Myocardial Infarction (STEMI) and Non‑ST‑Elevation Myocardial Infarction (NSTEMI) based on the SYNTAX score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cross-sectional study included 96 patients diagnosed with STEMI and NSTEMI from Razi University Hospital between April and September 2019. Ninety-six patients were diagnosed with STEMI (<i>N</i> = 43) and NSTEMI (<i>N</i> = 53) were recruited from South Khorasan, Iran. The angiographical characteristics of CAD were defined by the SYNTAX score. Genomic DNA was isolated from peripheral blood and genotyped for rs1801131 and rs1801133 using the TaqMan real-time PCR method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results of the one-way analysis of variance indicated that there is no association between rs1801131 and rs1801133 with the severity of coronary lesions in patients with STEMI (<i>p</i> = 0.44) and NSTEMI (<i>p</i> = 0.91). However, the two-way analysis of variance comparison and post-hoc test demonstrated that rs1801133 in the presence of rs1801131 is correlated with the SYNTAX score in NSTEMI (<i>p</i> = 0.03) and total patients (<i>p</i> = 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In conclusion, our study reveals a significant association between the MTHFR polymorphism rs1801133 and CAD severity, particularly in NSTEMI patients. While rs1801131 showed no correlation, rs1801133 may serve as a valuable genetic biomarker for assessing CAD severity. Further research with larger populations is needed to confirm these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propensity Score Matching Analysis for Alcohol-Related Liver Disease 酒精相关性肝病的倾向评分匹配分析

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-12 DOI: 10.1002/hsr2.70257

Fangfang Duan, Shanshan Song, Hang Zhai, Yazhi Wang, Jun Cheng, Song Yang

Objectives

This study aims to investigate the impact of comorbidity with chronic hepatitis B (CHB) on the survival rates and incidence of liver cancer in patients with alcohol-related liver disease (ARLD).

Methods

Patients with ARLD and those with ARLD co-morbid with CHB were included in this study and designated as the ARLD group and the ARLD + HBV group, respectively. Propensity score matching (PSM) was then employed to compare survival rates and liver cancer development between these two groups.

Results

Among the 404 patients, 254 were in the ARLD group and 150 in the ARLD + HBV group. After propensity score matching, each group comprised 67 patients. Initially, the ARLD + HBV group exhibited lower 5-year survival rates compared to the ARLD group (51.3% vs. 70.1%, p < 0.001). However, PSM mitigated this difference, with survival rates now comparable (61.2% vs. 60.9%, p = 0.390). Notably, the ARLD + HBV group showed a higher incidence of liver-specific mortality after matching (32.6% vs. 6.2%, p = 0.018). Furthermore, although a higher proportion of patients in the ARLD + HBV group developed liver cancer post-matching, the difference was not statistically significant compared to the ARLD group (15.7% vs. 9.8%, p = 0.170).

Conclusion

Co-morbidity with CHB in ARLD patients elevates the risk of liver-related mortality.

目的：本研究旨在探讨慢性乙型肝炎（CHB）合并症对酒精相关性肝病（ARLD）患者生存率和肝癌发病率的影响。方法：将ARLD合并慢性乙型肝炎患者和ARLD合并慢性乙型肝炎患者纳入本研究，分别分为ARLD组和ARLD + HBV组。然后采用倾向评分匹配（PSM）来比较两组之间的生存率和肝癌发展情况。结果：404例患者中，ARLD组254例，ARLD + HBV组150例。倾向评分匹配后，每组67例。最初，与ARLD组相比，ARLD + HBV组的5年生存率较低（51.3%对70.1%,p p = 0.390）。值得注意的是，ARLD + HBV组匹配后肝脏特异性死亡率发生率更高（32.6% vs. 6.2%, p = 0.018）。此外，虽然ARLD + HBV组患者配型后发生肝癌的比例较高，但与ARLD组相比差异无统计学意义（15.7% vs. 9.8%, p = 0.170）。结论：ARLD患者合并CHB可增加肝脏相关死亡风险。

{"title":"Propensity Score Matching Analysis for Alcohol-Related Liver Disease","authors":"Fangfang Duan, Shanshan Song, Hang Zhai, Yazhi Wang, Jun Cheng, Song Yang","doi":"10.1002/hsr2.70257","DOIUrl":"10.1002/hsr2.70257","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to investigate the impact of comorbidity with chronic hepatitis B (CHB) on the survival rates and incidence of liver cancer in patients with alcohol-related liver disease (ARLD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with ARLD and those with ARLD co-morbid with CHB were included in this study and designated as the ARLD group and the ARLD + HBV group, respectively. Propensity score matching (PSM) was then employed to compare survival rates and liver cancer development between these two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 404 patients, 254 were in the ARLD group and 150 in the ARLD + HBV group. After propensity score matching, each group comprised 67 patients. Initially, the ARLD + HBV group exhibited lower 5-year survival rates compared to the ARLD group (51.3% vs. 70.1%, <i>p</i> < 0.001). However, PSM mitigated this difference, with survival rates now comparable (61.2% vs. 60.9%, <i>p</i> = 0.390). Notably, the ARLD + HBV group showed a higher incidence of liver-specific mortality after matching (32.6% vs. 6.2%, <i>p</i> = 0.018). Furthermore, although a higher proportion of patients in the ARLD + HBV group developed liver cancer post-matching, the difference was not statistically significant compared to the ARLD group (15.7% vs. 9.8%, <i>p</i> = 0.170).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Co-morbidity with CHB in ARLD patients elevates the risk of liver-related mortality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Department Type and Disability Status on Medical School Faculty Wellbeing 院系类型和残疾状况对医学院教师幸福感的影响。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-09 DOI: 10.1002/hsr2.70317

Mohammed A. A. Abulela, Bethany Schowengerdt, Heather Dorr, Amanda Termuhlen, Kristina Krohn, Claudio Violato

Purpose

Faculty wellbeing impacts student learning and is a priority among medical schools, especially as a counterbalance to growing burnout. Previous researchers found differences in burnout by sex and race among clinicians, but not for faculty with disabilities. Accordingly, the purpose was to test the association between faculty's wellbeing, burnout, and control over workload and investigate differences in wellbeing attributed to department type and ability status.

Method

The authors developed and administered a comprehensive wellbeing survey to University of Minnesota Medical School faculty, of whom 703 provided complete responses. The authors conducted two-way ANOVA followed by a post hoc analysis to test for differences in faculty wellbeing domains due to department type (basic sciences, nonsurgical, surgical, and two large departments of Medicine and Pediatrics) and disability status (yes, no). The authors also fitted a two-way ordinal model since burnout frequency and control over workload were assessed by one ordinal item each.

Results

Wellbeing domains were positively correlated with control over workload but negatively associated with burnout. Faculty with disabilities reported less support from their work environment and meeting of their basic needs. Department type had a statistically significant impact on faculty's sense of basic needs, respect, and contribution. Multiple comparisons revealed faculty in basic sciences departments had higher scores within basic needs compared to the departments of Medicine, Pediatrics, and surgical departments, who reported lower levels of respect as well. Results revealed department type and disability status affected the frequency of burnout, as faculty in basic sciences departments reported lower levels of burnout compared to other departments.

Conclusions

Results support disaggregating wellbeing by department and ability status for targeted interventions due to differences- notably among faculty with disabilities and surgical departments- in their assessment of basic needs, work environment, respect, and contribution. Results suggest revisiting interventions in these domains to account for lower reported wellbeing.

目的：教师的福利影响学生的学习，是医学院的优先事项，特别是作为对日益增长的倦怠的平衡。先前的研究人员发现，临床医生在职业倦怠方面存在性别和种族差异，但对残疾教师没有影响。因此，本研究的目的是检验教师的幸福感、职业倦怠和工作量控制之间的关系，并探讨系系类型和能力状况在幸福感方面的差异。方法：作者对明尼苏达大学医学院教师进行了一项全面的健康调查，其中703人提供了完整的回答。作者进行了双向方差分析，随后进行了事后分析，以检验由于院系类型（基础科学、非外科、外科以及两个大的医学和儿科院系）和残疾状况（是，否）而导致的教师福利领域的差异。由于倦怠频率和对工作负荷的控制分别由一个顺序项目来评估，作者还拟合了一个双向顺序模型。结果：幸福感域与工作量控制呈正相关，与职业倦怠负相关。残疾教师报告说，他们的工作环境和基本需求得到的支持较少。院系类型对教师的基本需求感、受尊重感和贡献感有显著影响。多项比较显示，与内科、儿科和外科相比，基础科学院系的教师在基本需求方面得分更高，而这些院系的尊重程度也较低。结果显示，院系类型和残疾状况影响职业倦怠的频率，基础科学院系的教师报告的职业倦怠水平低于其他院系。结论：研究结果支持按院系和能力状况对有针对性的干预进行福利分类，因为在基本需求、工作环境、尊重和贡献的评估方面存在差异，尤其是在残疾教师和外科医生之间。研究结果建议重新审视这些领域的干预措施，以解释报告中幸福感较低的原因。

{"title":"Effects of Department Type and Disability Status on Medical School Faculty Wellbeing","authors":"Mohammed A. A. Abulela, Bethany Schowengerdt, Heather Dorr, Amanda Termuhlen, Kristina Krohn, Claudio Violato","doi":"10.1002/hsr2.70317","DOIUrl":"10.1002/hsr2.70317","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Faculty wellbeing impacts student learning and is a priority among medical schools, especially as a counterbalance to growing burnout. Previous researchers found differences in burnout by sex and race among clinicians, but not for faculty with disabilities. Accordingly, the purpose was to test the association between faculty's wellbeing, burnout, and control over workload and investigate differences in wellbeing attributed to department type and ability status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The authors developed and administered a comprehensive wellbeing survey to University of Minnesota Medical School faculty, of whom 703 provided complete responses. The authors conducted two-way ANOVA followed by a post hoc analysis to test for differences in faculty wellbeing domains due to department type (basic sciences, nonsurgical, surgical, and two large departments of Medicine and Pediatrics) and disability status (yes, no). The authors also fitted a two-way ordinal model since burnout frequency and control over workload were assessed by one ordinal item each.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Wellbeing domains were positively correlated with control over workload but negatively associated with burnout. Faculty with disabilities reported less support from their work environment and meeting of their basic needs. Department type had a statistically significant impact on faculty's sense of basic needs, respect, and contribution. Multiple comparisons revealed faculty in basic sciences departments had higher scores within basic needs compared to the departments of Medicine, Pediatrics, and surgical departments, who reported lower levels of respect as well. Results revealed department type and disability status affected the frequency of burnout, as faculty in basic sciences departments reported lower levels of burnout compared to other departments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Results support disaggregating wellbeing by department and ability status for targeted interventions due to differences- notably among faculty with disabilities and surgical departments- in their assessment of basic needs, work environment, respect, and contribution. Results suggest revisiting interventions in these domains to account for lower reported wellbeing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Effectiveness, Safety, and Satisfaction Rates of Phenol 90%, Trichloroacetic Acid 100%, and Radiofrequency in Lateral Matricectomy for the Treatment of Ingrown Toenails: A Triple-Arm Clinical Trial 评价苯酚90%、三氯乙酸100%和射频侧基质切除术治疗内生趾甲的有效性、安全性和满意率：一项三臂临床试验。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-08 DOI: 10.1002/hsr2.70326

Mohammadreza Ghassemi, Zahra Keshavarz, Elham Behrangi, Afsaneh Sadeghzadeh Bazargan, Alireza Jafarzadeh, Azadeh Goodarzi

Background and Aims

This study aimed to evaluate the effectiveness, safety, and satisfaction rates of three different lateral matricectomy methods for treating ingrown toenails: 90% phenol, 100% trichloroacetic acid (TCA), and radiofrequency (RF) ablation. Our objective was to identify which method offers superior outcomes regarding postoperative pain, healing time, aesthetic results, and complication rates.

Methods

Conducted between August 2022 and June 2023, the study included 12 eligible patients divided into three groups: Group 1 underwent lateral matricectomy with 90% phenol, Group 2 with 100% TCA, and Group 3 with RF treatment. Preoperative assessments were conducted, and patients were followed up on the day after surgery and at Weeks 1, 2, and 3, as well as at Months 1, 2, 6, and 9 postoperatively (totaling nine assessments). Pain levels were measured using the Visual Analog Scale (VAS), while wound discharge and bleeding were rated on specified scales.

Results

Mean pre- and postoperative (second day) pain scores were 6.0 ± 3.3 and 0.75 ± 0.67 for Group 1, 6.25 ± 4.92 and 1.75 ± 0.58 for Group 2, and 6.25 ± 2.25 and 3.50 ± 0.50 for Group 3, with significant differences observed. RF treatment showed higher moderate postoperative pain compared to mild pain in the phenol and TCA groups. Average healing time was 22.75 ± 3.50 days (phenol), 40 ± 12.91 days (TCA), and 26.25 ± 6.70 days (RF), with phenol demonstrating faster healing, although differences were statistically insignificant. The median aesthetic outcomes favored phenol with a score of 5.0.

Conclusion

Lateral matricectomy with 90% phenol, 100% TCA, and RF all provide unique advantages for ingrown toenail treatment. Phenol exhibited high success rates, minimal complications, faster healing, and excellent aesthetic outcomes.

Trial Registration

IRCT, IRCT20220228054152N1. Registered 03 January 2023, https://www.irct.behdasht.gov.ir/trial/65907.

背景和目的：本研究旨在评估三种不同侧基质切除术治疗内生趾甲的有效性、安全性和满意度：90%苯酚、100%三氯乙酸（TCA）和射频（RF）消融。我们的目的是确定哪种方法在术后疼痛、愈合时间、美学效果和并发症发生率方面具有更好的效果。方法：该研究于2022年8月至2023年6月进行，包括12名符合条件的患者，分为三组：1组接受90%苯酚侧基质切除术，2组接受100% TCA治疗，3组接受射频治疗。进行术前评估，术后第1、2、3周及术后第1、2、6、9个月随访患者（共9次评估）。采用视觉模拟量表（VAS）测量疼痛水平，并根据规定的量表对伤口排出量和出血量进行评分。结果：1组患者术后（第2天）平均疼痛评分分别为6.0±3.3、0.75±0.67,2组患者分别为6.25±4.92、1.75±0.58,3组患者分别为6.25±2.25、3.50±0.50，差异均有统计学意义。与苯酚组和TCA组相比，射频治疗显示出更高的中度术后疼痛。平均愈合时间为22.75±3.50天（苯酚），40±12.91天（TCA）和26.25±6.70天（RF），苯酚愈合更快，但差异无统计学意义。美学结果的中位数倾向于苯酚，得分为5.0。结论：90%苯酚、100% TCA和射频侧基质切除术治疗内生趾甲具有独特的优势。苯酚显示出高的成功率、最小的并发症、更快的愈合和良好的美学效果。试验注册：IRCT， IRCT20220228054152N1。2023年1月3日注册，https://www.irct.behdasht.gov.ir/trial/65907。

{"title":"Evaluating the Effectiveness, Safety, and Satisfaction Rates of Phenol 90%, Trichloroacetic Acid 100%, and Radiofrequency in Lateral Matricectomy for the Treatment of Ingrown Toenails: A Triple-Arm Clinical Trial","authors":"Mohammadreza Ghassemi, Zahra Keshavarz, Elham Behrangi, Afsaneh Sadeghzadeh Bazargan, Alireza Jafarzadeh, Azadeh Goodarzi","doi":"10.1002/hsr2.70326","DOIUrl":"10.1002/hsr2.70326","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>This study aimed to evaluate the effectiveness, safety, and satisfaction rates of three different lateral matricectomy methods for treating ingrown toenails: 90% phenol, 100% trichloroacetic acid (TCA), and radiofrequency (RF) ablation. Our objective was to identify which method offers superior outcomes regarding postoperative pain, healing time, aesthetic results, and complication rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Conducted between August 2022 and June 2023, the study included 12 eligible patients divided into three groups: Group 1 underwent lateral matricectomy with 90% phenol, Group 2 with 100% TCA, and Group 3 with RF treatment. Preoperative assessments were conducted, and patients were followed up on the day after surgery and at Weeks 1, 2, and 3, as well as at Months 1, 2, 6, and 9 postoperatively (totaling nine assessments). Pain levels were measured using the Visual Analog Scale (VAS), while wound discharge and bleeding were rated on specified scales.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mean pre- and postoperative (second day) pain scores were 6.0 ± 3.3 and 0.75 ± 0.67 for Group 1, 6.25 ± 4.92 and 1.75 ± 0.58 for Group 2, and 6.25 ± 2.25 and 3.50 ± 0.50 for Group 3, with significant differences observed. RF treatment showed higher moderate postoperative pain compared to mild pain in the phenol and TCA groups. Average healing time was 22.75 ± 3.50 days (phenol), 40 ± 12.91 days (TCA), and 26.25 ± 6.70 days (RF), with phenol demonstrating faster healing, although differences were statistically insignificant. The median aesthetic outcomes favored phenol with a score of 5.0.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Lateral matricectomy with 90% phenol, 100% TCA, and RF all provide unique advantages for ingrown toenail treatment. Phenol exhibited high success rates, minimal complications, faster healing, and excellent aesthetic outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>IRCT, IRCT20220228054152N1. Registered 03 January 2023, https://www.irct.behdasht.gov.ir/trial/65907.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal Shock Waves Therapy for the Treatment of Acute and Chronic Wounds—A Prospective, Monocentric Clinical Trial to Examine the Effect of Shock Waves on Wound Healing 体外冲击波治疗急性和慢性伤口——一项前瞻性、单中心临床试验，研究冲击波对伤口愈合的影响。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-08 DOI: 10.1002/hsr2.70311

Kristina Landscheidt, Ahmed Alabdulmohsen, Markus Hübscher, Benjamin Geber, Jochen-Frederick Hernekamp, Ole Goertz

Introduction

The aim of our prospective blinded clinical study was to examine a possible improvement and acceleration of epithelialization by treatment with low-energy extracorporeal shock waves on skin graft donor and recipient sites in patients with chronic wounds. In addition, several secondary parameters were investigated to evaluate the compatibility of the therapeutic method, its influence on infection occurrence and bacterial colonization.

Materials and Methods

A total of 35 patients were included in the study. Of these, 25 participants were assigned to the verum-placebo group and 10 to the sham treatment group. The study of the sham control group was done to exclude a possible “remote effect” of the placebo area. Depending on the group, the wound areas were treated with low-frequency shock waves, placebo, or sham. The examinations were performed immediately on Day 0 after surgical treatment and on Days 5, 7, 9, and 12 after surgery. To record long-term results, an additional evaluation of the wound situation was performed on Day 90.

Results

Epithelialization was statistically significantly accelerated by shock wave application at both skin graft recipient sites and donor sites (0.86 vs. 0.92, p < 0.05). Furthermore, the risk of wound infection was significantly reduced by using extracorporeal shock waves. Serious side effects were not reported.

Conclusion

A repeated application of ESWT followed by standardized wound care was shown to significantly accelerate the time to re-epithelialization at the skin graft donor and recipient site compared with re-epithelialization time in patients of the sham/placebo group.

简介：本前瞻性盲法临床研究的目的是研究在慢性伤口患者中，低能量体外冲击波对皮肤移植供体和受体部位的治疗可能改善和加速上皮化。此外，研究了几个次要参数，以评估治疗方法的相容性，其对感染发生和细菌定植的影响。材料与方法：共纳入35例患者。其中，25名参与者被分配到安慰剂组，10名参与者被分配到假治疗组。对假对照组的研究是为了排除安慰剂区域可能的“远程效应”。根据组的不同，伤口部位用低频冲击波、安慰剂或假药治疗。术后第0天及术后第5、7、9、12天立即进行检查。为了记录长期结果，在第90天对伤口情况进行了额外的评估。结果：冲击波在皮肤移植受体和供体部位的应用均显著加速了皮肤移植的上皮化（0.86比0.92,p）。结论：与假/安慰剂组患者的再上皮化时间相比，重复应用ESWT并进行标准化伤口护理可显著加快皮肤移植供体和受体部位的再上皮化时间。

{"title":"Extracorporeal Shock Waves Therapy for the Treatment of Acute and Chronic Wounds—A Prospective, Monocentric Clinical Trial to Examine the Effect of Shock Waves on Wound Healing","authors":"Kristina Landscheidt, Ahmed Alabdulmohsen, Markus Hübscher, Benjamin Geber, Jochen-Frederick Hernekamp, Ole Goertz","doi":"10.1002/hsr2.70311","DOIUrl":"10.1002/hsr2.70311","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The aim of our prospective blinded clinical study was to examine a possible improvement and acceleration of epithelialization by treatment with low-energy extracorporeal shock waves on skin graft donor and recipient sites in patients with chronic wounds. In addition, several secondary parameters were investigated to evaluate the compatibility of the therapeutic method, its influence on infection occurrence and bacterial colonization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A total of 35 patients were included in the study. Of these, 25 participants were assigned to the verum-placebo group and 10 to the sham treatment group. The study of the sham control group was done to exclude a possible “remote effect” of the placebo area. Depending on the group, the wound areas were treated with low-frequency shock waves, placebo, or sham. The examinations were performed immediately on Day 0 after surgical treatment and on Days 5, 7, 9, and 12 after surgery. To record long-term results, an additional evaluation of the wound situation was performed on Day 90.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Epithelialization was statistically significantly accelerated by shock wave application at both skin graft recipient sites and donor sites (0.86 vs. 0.92, <i>p</i> < 0.05). Furthermore, the risk of wound infection was significantly reduced by using extracorporeal shock waves. Serious side effects were not reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A repeated application of ESWT followed by standardized wound care was shown to significantly accelerate the time to re-epithelialization at the skin graft donor and recipient site compared with re-epithelialization time in patients of the sham/placebo group.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0