Health Science Reports最新文献_第8页

Unlocking the Healing Potential: A Comprehensive Review of Ecology and Biology of Medical-Grade Honey in Wound Management and Tissue Regeneration 解锁愈合潜力：药用级蜂蜜在伤口管理和组织再生中的生态学和生物学综合综述。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-16 DOI: 10.1002/hsr2.70240

Parmis Barazesh, Helia Hajihassani, Fatemeh Motalebi, Seyedeh Mobina Hosseini Neiresi, Romina Hajihassani, Ahmad Reza Mehrabian

Background and Aims

Honey has long been studied for its healing abilities in wound care. This narrative review examines its properties and their impact on wound healing, particularly its ability to accelerate wound closure and promote tissue regeneration. The review focuses on how honey's botanical origins affect its medical properties and wound-healing capabilities. Finally, clinical studies on honey's effectiveness in wound healing were reviewed compared to traditional treatments.

Methods

Relevant keywords were searched in databases, yielding 1250 documents. After excluding nonrelevant sources, 450 documents were refined, and 167 articles were selected based on thematic alignment and originality. Data extraction focused on study design, intervention details, and outcomes, with quality assessed using standardized criteria. The study adhered to CONSORT and SANRA guidelines to ensure methodological rigor and reporting transparency.

Results

Honey-based medical products have demonstrated significant antibacterial, anti-inflammatory, and tissue-regenerative properties, making them highly effective in improving wound healing outcomes, particularly in chronic and burn wounds. These products have also been shown to reduce infection rates and hospital stays. While some studies have reported positive outcomes in accelerating the healing process, others have found no significant difference compared to conventional treatments.

Conclusion

Medical-grade honey (MGH) holds potential for wound care due to its versatility, though variations in its composition present challenges. Further research is needed to optimize its clinical use. The effectiveness of MGH in wound healing remains debated, with mixed results from trials. Genetic modification of bees to enhance MGH's properties could make it more competitive against conventional treatments. Honey-based medications could reduce costs, improve energy efficiency, and have minimal side effects. Rigorous research is necessary to determine optimal use and fully unlock MGH's potential, which could revolutionize wound management globally.

背景和目的：长期以来，人们一直在研究蜂蜜在伤口护理中的愈合能力。本文综述了其特性及其对伤口愈合的影响，特别是其加速伤口愈合和促进组织再生的能力。这篇综述的重点是蜂蜜的植物来源如何影响其医学特性和伤口愈合能力。最后，对蜂蜜在伤口愈合中的临床研究进行了综述，并与传统治疗方法进行了比较。方法：在数据库中检索相关关键词，得到1250篇文献。在排除非相关来源后，对450份文件进行了提炼，并根据主题一致性和独创性选择了167篇文章。数据提取侧重于研究设计、干预细节和结果，并使用标准化标准评估质量。该研究遵循CONSORT和SANRA指南，以确保方法的严谨性和报告的透明度。结果：蜂蜜为基础的医疗产品已经证明了显著的抗菌、抗炎和组织再生特性，使它们在改善伤口愈合结果方面非常有效，特别是在慢性和烧伤伤口。这些产品也被证明可以降低感染率和住院时间。虽然一些研究报告了加速愈合过程的积极结果，但其他研究发现与传统治疗相比没有显着差异。结论：医用级蜂蜜（MGH）由于其多功能性而具有伤口护理的潜力，尽管其成分的变化带来了挑战。需要进一步研究以优化其临床应用。MGH在伤口愈合中的有效性仍存在争议，试验结果好坏参半。对蜜蜂进行基因改造以增强MGH的特性，可能使其与传统疗法相比更具竞争力。以蜂蜜为基础的药物可以降低成本，提高能源效率，并且副作用最小。必须进行严格的研究，以确定最佳使用方法并充分释放MGH的潜力，这可能会给全球伤口管理带来革命性的变化。

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引用次数: 0

Comparative Analysis of COVID-19 Severity and Mortality Among Vaccinated and Unvaccinated Individuals During the Delta Variant Surge in a Tertiary Care Center: A Cohort Study 三级医疗中心Delta变异激增期间接种疫苗和未接种疫苗个体COVID-19严重程度和死亡率的比较分析：一项队列研究

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-16 DOI: 10.1002/hsr2.70346

Fatemeh Hasani, Zahra Norouzi, Kimia Jazi, Gholamreza Roshandel, Alireza Norouzi

Background and Aims

On March 11, 2020, the World Health Organization declared Coronavirus disease 2019 (COVID-19) as a pandemic. The spread of the Delta variant of coronavirus started in June 2021 and accounted for the fifth peak of COVID-19 in Iran in July 2021. According to reports from other countries, vaccination protects against severe diseases caused by COVID-19, including the Delta variant. Studies have also shown that vaccination provides strong protection against SARS-CoV-2 infection, COVID-19-related hospitalization, and mortality. This retrospective cohort study was designed based on the medical care monitoring center database of Sayyad Shirazi Hospital.

Methods

COVID-19 confirmed patients' data were extracted for this study from June 22, 2021, to September 22, 2021 including demographic characteristics, signs and symptoms, ICU admission, need for aggressive oxygen therapy, including intubation, mortality, and vaccination status.

Results

A total of 2962 patients were enrolled. Being vaccinated was associated with a 4.14-fold increase in survival (adjusted OR = 4.14; 95% CI: 2.22–7.69; p < 0.01), and individuals in a younger age group demonstrated a 5.58-fold higher likelihood of surviving (adjusted OR = 5.58; 95% CI: 4.25–8.14; p < 0.01). The risk of severe COVID-19 was significantly lower in vaccinated individuals, showing a 3.12-fold decrease in risk (adjusted OR = 3.12; 95% CI: 2.06–4.72; p < 0.01), and in younger age groups, the risk exhibited a 3.28-fold decrease (adjusted OR = 3.28; 95% CI: 2.66–4.04; p < 0.01).

Conclusion

The present results suggest that receiving at least one dose of COVID-19 vaccine had a significant relationship with decreased COVID-19 severity and mortality in vaccinated patients compared to unvaccinated patients.

背景和目的：2020年3月11日，世界卫生组织宣布2019冠状病毒病（COVID-19）为大流行。Delta型冠状病毒的传播始于2021年6月，并于2021年7月在伊朗出现了COVID-19的第五个高峰。根据其他国家的报告，接种疫苗可以预防由COVID-19引起的严重疾病，包括Delta变体。研究还表明，疫苗接种可提供强有力的保护，防止SARS-CoV-2感染、与covid -19相关的住院和死亡率。本回顾性队列研究基于Sayyad Shirazi医院医疗监护中心数据库设计。方法：提取2021年6月22日至2021年9月22日期间COVID-19确诊患者的资料，包括人口统计学特征、体征和症状、ICU入院情况、积极氧疗需求（包括插管）、死亡率和疫苗接种情况。结果：共纳入2962例患者。接种疫苗与存活增加4.14倍相关(调整OR = 4.14；95% ci: 2.22-7.69；结论：与未接种疫苗的患者相比，接种至少一剂COVID-19疫苗与COVID-19严重程度和死亡率降低有显著关系。

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引用次数: 0

Assessment of Bendopnea and Its Association With Clinical and Para-Clinical Findings in Systolic Heart Failure: A Cross-Sectional Study 收缩期心力衰竭的腹弓通气评估及其与临床和准临床表现的关系：一项横断面研究。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-16 DOI: 10.1002/hsr2.70354

Elmira Javanmardi, Tara Reshadmanesh, Sepehr Gohari, Amir Hossein Behnoush, Hassan Ahangar

Background and Aims

Bendopnea is a symptom found in patients with heart failure (HF) defined as shortness of breath when bending forward. The present study examined the correlation between bendopnea with other cardiac symptoms, echocardiographic findings, and cardiac function parameters.

Methods

This was a single-center prospective cross-sectional study of patients diagnosed with systolic HF. Medical history, bending tests, laboratory tests, electrocardiography (ECG), echocardiography, and 6-min walking test (6-MWT) were evaluated. Patients with reduced ejection fraction were followed to assess the 2-year outcomes for cardiovascular death and rehospitalization.

Results

A total of 80 patients were included in this study, of whom 54 (67.5%) were male. Bendopnea was present in 34 (42.5%) and their mean age was 62.44 years (compared to group without bendopnea, p = 0.869). Symptoms of HF such as dyspnea of exertion (DOE) and orthopnea were significantly related to the presence of bendopnea (p = 0.001, odds ratio (OR): 6.87, and p = 0.016, OR: 3.18, respectively). The bendopnea-positive group had a higher New York Heart Association (NYHA) class (p = 0.005). ECG results showed no significant difference between the two groups. The echocardiographic findings showed that the inferior vena cava (IVC) respiratory collapse was significantly lower in the bendopnea-positive group (p = 0.019, OR: 0.339, 95% CI:0.13–0.85). Moreover, they had a substantially lower performance in 6-MWT (387.39 vs. 325.58 m, p = 0.015). Neither rehospitalization nor death was related to bendopnea after a 2-year follow-up (p = 0.454).

Conclusion

Bendopnea was associated with several signs and symptoms of HF, including orthopnea, DOE, NYHA class, lower IVC collapse, and impaired functional capacity measured via 6-MWT. However, there was no association between bendopnea and ECG findings, ejection fraction, and NT-proBNP levels. Further studies with larger sample sizes are needed to assess the associations with long-term outcomes and confirm our findings.

背景和目的：腹屈通气是心力衰竭（HF）患者的一种症状，定义为向前弯腰时呼吸急促。本研究探讨了腹主动脉瓣闭与其他心脏症状、超声心动图表现和心功能参数的相关性。方法：这是一项诊断为收缩期心衰的患者的单中心前瞻性横断面研究。评估病史、弯曲试验、实验室试验、心电图（ECG）、超声心动图和6分钟步行试验（6-MWT）。对射血分数降低的患者进行随访，以评估心血管死亡和再住院的2年结局。结果：本研究共纳入80例患者，其中男性54例（67.5%）。34例（42.5%）存在弯曲性呼吸障碍，平均年龄为62.44岁（与无弯曲性呼吸障碍组比较，p = 0.869）。心力衰竭的症状如用力呼吸困难（DOE）和矫形呼吸与弯曲呼吸的存在显著相关（p = 0.001，优势比（OR）： 6.87, p = 0.016, OR: 3.18）。bendopnea阳性组纽约心脏协会（NYHA）分级较高（p = 0.005）。两组心电图结果无明显差异。超声心动图结果显示，benendopnea阳性组下腔静脉（IVC）呼吸衰竭发生率明显降低（p = 0.019, OR: 0.339, 95% CI:0.13-0.85）。此外，他们在6-MWT中的表现明显较低（387.39 vs. 325.58 m, p = 0.015）。2年随访后，再住院和死亡均与弯曲通气无关（p = 0.454）。结论：弯曲通气与HF的几种体征和症状相关，包括骨科通气、DOE、NYHA分级、下腔静脉塌陷和通过6-MWT测量的功能能力受损。然而，腹主动脉瓣闭合与心电图表现、射血分数和NT-proBNP水平之间没有关联。需要更大样本量的进一步研究来评估其与长期结果的关系，并证实我们的发现。

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引用次数: 0

Using Real-Time Power BI Formative Feedback to Improve Nurse Anesthesia Students' Clinical Competence: An Educational Intervention 利用实时功率BI形成性反馈提高麻醉护理生临床能力：一种教育干预。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-16 DOI: 10.1002/hsr2.70358

Ali Khalafi, Sajjad Choopani, Nooshin Sarvi-Sarmeydani, Elham Maraghi

Background and Aims

The escalating complexity of diseases and the burgeoning demand for proficient nurse anesthetists underscore the critical need for graduates optimally equipped to deliver competent care across varying patient conditions. Given the gap between the expected and actual clinical competencies among graduates, this study aimed to evaluate the impact of formative assessment coupled with immediate online feedback on the clinical competence of anesthesia nursing students in peri-anesthesia care.

Methods

This educational intervention was conducted with the participation of nurse anesthesia students who were enrolled into intervention and control groups. The intervention entailed providing immediate, web-based feedback on students' performance through a visual dashboard on Microsoft Power BI, along with weekly assessments using the Common Clinical Assessment Tool (CCAT). The control group received traditional, verbal feedback.

Results

Statistical analysis revealed significant improvements in clinical competence scores in the intervention group compared to the control group. The intervention group showed a notable progression in clinical competency scores from baseline to endpoint (mean scores: 35.06 ± 1.62 to 79.58 ± 1.02), significantly outperforming the control group (mean scores: 29.93 ± 1.38 to 62.09 ± 1.47, p-value < 0.0001).

Conclusions

Integrating formative assessment with immediate online feedback (e.g., Microsoft Power BI) demonstrably enhances clinical competence in student nurse anesthetists. This study advocates for such advanced feedback mechanisms in competency-based nursing education to address competency gaps. These innovative approaches to education and evaluation hold promise for preparing competent nurse anesthetists, potentially leading to improved anesthesia care quality and patient safety.

背景和目的：不断升级的疾病复杂性和对熟练护士麻醉师的迅速增长的需求强调了对毕业生的迫切需求，他们有能力在不同的病人条件下提供合格的护理。鉴于毕业生的临床能力预期与实际存在差距，本研究旨在评估形成性评估结合即时在线反馈对麻醉护理学生围麻醉护理临床能力的影响。方法：采用麻醉护理专业学生参与教育干预，分为干预组和对照组。干预包括通过Microsoft Power BI上的可视化仪表板对学生的表现提供即时的、基于网络的反馈，以及使用通用临床评估工具（CCAT）进行每周评估。对照组接受传统的口头反馈。结果：经统计分析，干预组临床能力评分较对照组有显著提高。干预组临床能力得分从基线到终点均有显著提高（平均得分：35.06±1.62至79.58±1.02），显著优于对照组（平均得分：29.93±1.38至62.09±1.47，p值）结论：将形成性评估与即时在线反馈（如Microsoft Power BI）相结合，可显著提高麻醉实习护士的临床能力。本研究提倡在以能力为基础的护理教育中建立这种先进的反馈机制，以解决能力差距。这些创新的教育和评估方法有望培养合格的麻醉师护士，潜在地提高麻醉护理质量和患者安全。

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引用次数: 0

Risk Factors and Patterns of Drug-Drug Interactions in Two Categories of Level-3 Hospitals in Dhaka: A Cross-Sectional Study 达卡两类三级医院的危险因素和药物相互作用模式：一项横断面研究

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-14 DOI: 10.1002/hsr2.70355

Md. Abdus Samadd, Farhan Tanvir Patwary, Md Momin Islam, Ashfia Tasnim Munia, K. M. Yasif Kayes Sikdar, Md. Raihan Sarkar

Background and Aims

Drug-drug interactions (DDIs) are a significant health issue that may adversely affect the health and well-being of patients. This study assesses and compares potential DDI (pDDI) patterns, severity, and associated risk factors in government and private hospitals in Dhaka, Bangladesh.

Methods

A total of 188 and 206 prescriptions were collected from various government and private hospitals' outdoor departments, respectively, by capturing pictures of the prescriptions. Bivariate analyses were performed through STATA 15. MedScape drug interaction checker was applied to identify pDDIs, while their consequences were obtained from DrugBank and MedScape.

Results

Private hospitals had more pDDIs containing prescriptions than government hospitals (62.62% and 57.97%, respectively). The mean pDDIs cases were 3.29 in the private hospitals, while at government hospitals they were 3.02. Among the detected pDDIs, pharmacodynamic pDDIs were predominat, accounting for 63.32% and 66.23% of total events in government and private hospitals, respectively. Severity-wise, both types of hospitals had almost equal amounts of serious (10.34% vs. 9.18%), moderate (68.96% vs. 59.61%), and minor (20.06% vs. 21.79%) pDDIs. Polypharmacy was crucial in pDDI cases, responsible for 70.21% and 81.83% of pDDIs in government and private hospitals, respectively. Multiple comorbidities with pDDIs were more common in private hospitals (24.46% vs. 18.93%), while government hospitals displayed a higher frequency of pDDIs with one comorbidity (24.75% vs. 17.55%). Non-mention of comorbidities was correlated with both types of hospitals (p ≤ 0.01) in pDDIs cases. Furthermore, considerable amounts of pDDIs in prescription error categories were detected. Both types of hospitals had a prevalence of antihypertensive, antidiabetic, psychotic, and antiplatelet-related pDDIs.

Conclusion

The two kinds of hospitals exhibited similar pDDI patterns, while their associations were random with the risk variables. When prescribing pharmacokinetics and pharmacodynamics pDDIs, physicians should evaluate the risk-benefit ratio.

背景和目的：药物-药物相互作用（ddi）是一个重要的健康问题，可能会对患者的健康和福祉产生不利影响。本研究评估并比较了孟加拉国达卡政府医院和私立医院的潜在DDI （pDDI）模式、严重程度和相关风险因素。方法：对各公立医院和民营医院的室外科室分别采集处方188张和206张。通过STATA 15进行双变量分析。使用MedScape药物相互作用检查器识别pddi，并从DrugBank和MedScape获取其后果。结果：私立医院的pddi含处方率高于公立医院（分别为62.62%和57.97%）。私立医院平均pddi病例为3.29例，公立医院平均pddi病例为3.02例。在检测到的pddi中，以药效学pddi为主，分别占公立医院和私立医院总事件的63.32%和66.23%。从严重程度上看，两类医院的重度（10.34%对9.18%）、中度（68.96%对59.61%）和轻度（20.06%对21.79%）pddi数量几乎相等。多药联用是pDDI病例的关键，分别占公立医院和私立医院pDDI的70.21%和81.83%。私立医院多发多发pddi(24.46%比18.93%)，而公立医院多发多发多发pddi（24.75%比17.55%）。两种类型医院的pdis患者未提及合并症相关（p≤0.01）。此外，在处方错误类别中检测到相当数量的pddi。两类医院均存在抗高血压、抗糖尿病、精神病性和抗血小板相关pddi的患病率。结论：两类医院的pDDI模式相似，但其与风险变量的关联是随机的。在处方药代动力学和药效学pddi时，医生应评估风险-收益比。

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引用次数: 0

Surgical Practice in Resource-Limited Settings: Perspectives of Medical Students and Early Career Doctors: A Narrative Review 资源有限环境下的外科实践：医学生和早期职业医生的视角：叙述回顾。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-14 DOI: 10.1002/hsr2.70352

BillSmith Anyinkeng Achanga, Christian Wabene Bisimwa, Victor Oluwafemi Femi-Lawal, Nnoko Sona Akwo, Tohson Falake Toh

Introduction

Surgical practices in low-resource countries often fail to meet established standards. Both doctors and medical students have limited exposure to surgical cases, which hinders training and the development of surgical specialization. This study highlights the current state of surgical practice from a trainee's perspective, explores existing gaps in training and capacity building, and recommends practical solutions.

Methods

We conducted a literature search on PubMed, Google Scholar, and other scientific databases using search terms such as “surgical practice,” “doctors' perspectives in surgical practice,” “surgery in low- and middle-income countries,” and “solutions to surgical inadequacy.” We included studies published from 2015 to 2024, with exceptions for a few highly relevant studies published prior to 2015.

Results

We outline the limitations identified in the literature concerning surgical training and healthcare in low- and middle-income countries. Many centers lack adequate infrastructure, human resources, and training. These challenges negatively affect the skills and quality of surgical care. However, some centers demonstrate that surgical practice is feasible through collaboration with institutions established in higher-income contexts.

Conclusion

Telesurgery, task shifting and sharing, high-impact, low-cost surgeries, and collaborations with more developed health systems could effectively bridge the gap in surgical availability in LMICs.

在资源匮乏的国家，外科手术常常达不到既定标准。医生和医学生接触外科病例的机会有限，这阻碍了外科专业的培训和发展。本研究从受训者的角度强调了外科实践的现状，探讨了培训和能力建设中存在的差距，并提出了切实可行的解决方案。方法：我们对PubMed、谷歌Scholar和其他科学数据库进行了文献检索，检索词包括“外科实践”、“医生在外科实践中的观点”、“低收入和中等收入国家的外科”和“手术不足的解决方案”。我们纳入了2015年至2024年发表的研究，除了2015年之前发表的一些高度相关的研究。结果：我们概述了在低收入和中等收入国家有关外科培训和医疗保健的文献中确定的局限性。许多中心缺乏足够的基础设施、人力资源和培训。这些挑战对外科护理的技能和质量产生了负面影响。然而，一些中心表明，通过与高收入地区建立的机构合作，外科手术是可行的。结论：远程手术、任务转移和分担、高影响、低成本手术以及与更发达的卫生系统合作可以有效地弥补中低收入国家手术可及性的差距。

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引用次数: 0

Examining Gender Differences in Aggression as a Predictor of Anxiety, Depression, and Suicide in a Cross-Sectional French Sample 在法国横断面样本中研究攻击性的性别差异作为焦虑、抑郁和自杀的预测因子。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-13 DOI: 10.1002/hsr2.70359

Sylvia Martin

Background and Aims

The expected outcomes of the Covid-19 pandemic have a supposedly worsened impact on mental health and suicidal risk. Traditionally, males were supposed to have heightened Aggression and impulsivity in stressful times. We aim to measure the actual differences that existed during the COVID-19 pandemic across male and female participants.

Methods

An overall number of 288 females/95 males (mean age: men = 34.97; women = 32.90 years) participants were recruited. The protocol included questionnaires about suicidal risk, anxiety, depression, impulsivity, aggression, hopelessness, and demographics.

Results

Differences exist in the sense of loneliness, the number of persons being isolated with, anxiety, and several impulsivity subdimensions. A correlation existed for both men and women for anxiety and depression, revealing the impact of aggression. Suicide men's scores correlated with anxiety and depression, lack of premeditation, and hopelessness. Women also had such correlation, except for lack of perseverance, social dimensions, and aggression. Analyses reveal the predictive impact of hopelessness and aggression on anxiety, depression, and suicidal risk predominantly in females.

Conclusion

Our results contradict common ideas that men have heightened aggression and impulsivity. Further research needs to address aggression issues.

背景和目的：Covid-19大流行的预期结果据称对心理健康和自杀风险的影响更严重。传统上，人们认为男性在压力大的时候更具攻击性和冲动性。我们的目标是衡量在COVID-19大流行期间男性和女性参与者之间存在的实际差异。方法：女性288例，男性95例，平均年龄34.97岁；女性= 32.90岁)的参与者被招募。该方案包括关于自杀风险、焦虑、抑郁、冲动、攻击、绝望和人口统计的问卷调查。结果：在孤独感、被孤立人数、焦虑和冲动几个维度上存在差异。男性和女性在焦虑和抑郁方面都存在相关性，这揭示了攻击性的影响。自杀男性的得分与焦虑、抑郁、缺乏预谋和绝望有关。女性除了缺乏毅力、社会维度和攻击性之外，也有这种相关性。分析显示，绝望和攻击对焦虑、抑郁和自杀风险的预测影响主要发生在女性身上。结论：我们的研究结果与普遍认为男性更具攻击性和冲动性的观点相矛盾。进一步的研究需要解决侵略问题。

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引用次数: 0

Analysis of Body Fluid Distribution, Phase Angle and Its Association With Maximal Oxygen Consumption in Facioscapulohumeral Dystrophy: An Observational Study 面肩肱骨营养不良患者体液分布、相位角及其与最大耗氧量的关系分析：一项观察性研究。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-13 DOI: 10.1002/hsr2.70335

Oscar Crisafulli, Renato Baptista, Patrik Drid, Luca Grattarola, Giorgio Bottoni, Emanuela Lavaselli, Massimo Negro, Rossella Tupler, Venere Quintiero, Giuseppe D'Antona

Background and Aims

Body composition parameters associated with aerobic fitness, mirrored by maximal oxygen consumption (V̇O₂max), have recently gained interest as indicators of physical efficiency in facioscapulohumeral dystrophy (FSHD). Bioimpedance analysis (BIA) allows a noninvasive and repeatable estimate of body composition but is based on the use of predictive equations which, if used in cohorts with different characteristics from those for which the equation was originally formulated, could give biased results. Instead, the phase angle (PhA), a BIA raw bioelectrical parameter reflecting body fluids distribution, could provide reliable data for such analysis.

Methods

33 clinically and genetically characterized FSHD patients (mean age 35.7; 10 females) and 27 sex and age-matched healthy controls (HC) were included in the analysis. BIA was used to evaluate body fluids distribution (intracellular water [ICW], extracellular water [ECW], and total body water [TBW]), and PhA, while cardiopulmonary exercise test was used to estimate V̇O₂max.

Results

The groups were comparable for ECW and TBW. Instead, patients showed lower values of ICW (p = 0.020), ICW/ECW ratio (p < 0.001), and PhA (p < 0.001). Moreover, patients reported lower V̇O₂max (p = 0.001 for absolute values; p = 0.002 for values expressed in relation to body weight) which, unlike HC, was not associated to PhA.

Conclusion

Based on our results, PhA of FSHD patients is lower than HC. Since PhA mirrors the ICW/ECW ratio, the lower share of ICW seems to be the basis of such difference. Given the lack of association with V̇O₂max, PhA cannot be considered a reliable indicator of aerobic fitness in FSHD.

背景和目的：与有氧适能相关的身体成分参数，通过最大耗氧量（V * O2max）来反映，最近作为面部肩胛骨营养不良（FSHD）身体效率的指标得到了关注。生物阻抗分析（BIA）允许对身体成分进行无创和可重复的估计，但它是基于预测方程的使用，如果在具有不同特征的队列中使用，则可能会给出有偏差的结果。相反，反映体液分布的BIA原始生物电参数相角（PhA）可以为此类分析提供可靠的数据。方法：33例临床和遗传特征明显的FSHD患者(平均年龄35.7岁；10名女性)和27名性别和年龄匹配的健康对照（HC）纳入分析。采用BIA评估体液分布（细胞内水分[ICW]、细胞外水分[ECW]、全身水分[TBW]）和PhA，采用心肺运动试验评估V * O2max。结果：两组ECW和TBW具有可比性。相反，患者表现出较低的ICW值（p = 0.020）， ICW/ECW比值(p = 0.001；p = 0.002表示与体重有关的值)，这与HC不同，与PhA无关。结论：FSHD患者的PhA低于HC。由于PhA反映了ICW/ECW比率，ICW的较低份额似乎是这种差异的基础。由于PhA与vo2max缺乏相关性，因此它不能被认为是FSHD患者有氧适能的可靠指标。

{"title":"Analysis of Body Fluid Distribution, Phase Angle and Its Association With Maximal Oxygen Consumption in Facioscapulohumeral Dystrophy: An Observational Study","authors":"Oscar Crisafulli, Renato Baptista, Patrik Drid, Luca Grattarola, Giorgio Bottoni, Emanuela Lavaselli, Massimo Negro, Rossella Tupler, Venere Quintiero, Giuseppe D'Antona","doi":"10.1002/hsr2.70335","DOIUrl":"10.1002/hsr2.70335","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Body composition parameters associated with aerobic fitness, mirrored by maximal oxygen consumption (V̇O<sub>2</sub>max), have recently gained interest as indicators of physical efficiency in facioscapulohumeral dystrophy (FSHD). Bioimpedance analysis (BIA) allows a noninvasive and repeatable estimate of body composition but is based on the use of predictive equations which, if used in cohorts with different characteristics from those for which the equation was originally formulated, could give biased results. Instead, the phase angle (PhA), a BIA raw bioelectrical parameter reflecting body fluids distribution, could provide reliable data for such analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>33 clinically and genetically characterized FSHD patients (mean age 35.7; 10 females) and 27 sex and age-matched healthy controls (HC) were included in the analysis. BIA was used to evaluate body fluids distribution (intracellular water [ICW], extracellular water [ECW], and total body water [TBW]), and PhA, while cardiopulmonary exercise test was used to estimate V̇O<sub>2</sub>max.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The groups were comparable for ECW and TBW. Instead, patients showed lower values of ICW (<i>p</i> = 0.020), ICW/ECW ratio (<i>p</i> < 0.001), and PhA (<i>p</i> < 0.001). Moreover, patients reported lower V̇O<sub>2</sub>max (<i>p</i> = 0.001 for absolute values; <i>p</i> = 0.002 for values expressed in relation to body weight) which, unlike HC, was not associated to PhA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on our results, PhA of FSHD patients is lower than HC. Since PhA mirrors the ICW/ECW ratio, the lower share of ICW seems to be the basis of such difference. Given the lack of association with V̇O<sub>2</sub>max, PhA cannot be considered a reliable indicator of aerobic fitness in FSHD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-13 DOI: 10.1002/hsr2.70338

Andrea R. Costantine, Sarah J. Urasa, Abid M. Sadiq, Elichilia R. Shao, Furaha S. Lyamuya, Elieishiupendo M. Niccodem, Eugénie M. Kamabu, Venance P. Maro, Elifuraha W. Mkwizu, Nyasatu G. Chamba, Francis F. Furia, Tumaini E. Mirai, Eliada B. Nziku, Doreen T. Eliah, Ibrahim Ali Ibrahim Muhina, Faryal M. Raza, Modesta P. Mitao, Kajiru G. Kilonzo

Background and Aims

A catheter-related bloodstream infection (CRBSI) is a life-threatening complication of hemodialysis. It is responsible for significant morbidity and mortality and a costly long hospital stay. Despite its burden, little is known about the factors associated with it and the antibiogram of its responsible causative bacteria. This study aimed to evaluate the determinants of hemodialysis CRBSI and the appropriate antibiogram for the isolated bacterial pathogens among patients attending the KCMC hemodialysis unit.

Methods

A hospital-based retrospective analytical cross-sectional study involved adult patients with CKD or AKI undergoing hemodialysis at KCMC with tunneled or non-tunneled central venous catheters who attended from January 1, 2021 to December 31, 2022. Data were collected from the hospital's electronic medical record system. Statistical analysis was performed using SPSS version 27. Multivariate logistic regression was used to determine the factors associated with CRBSI. A p-value of < 0.05 was considered statistically significant.

Results

A total of 286 patients were analyzed. The patients were predominantly males (70.6%), and more than half were above 55 years old (56%), with a mean age of 58 (SD ± 14.8) years. 56.6% developed CRBSI and were predominantly gram-positive (69.7%). Major associated factors were hypoalbuminemia of < 35 g/dL, diabetes mellitus, anemia of hemoglobin < 10 g/dL, and having a femoral central venous catheter. For gram-positive bacteria, the most efficient antibiotic was vancomycin, with an overall average efficacy of 99% for all isolates. For gram-negative bacteria, the most efficient antibiotic was meropenem, with an overall average efficacy of 82.1% for all isolates.

Conclusion

Over 50% of patients developed CRBSI and gram-positive bacteria were the major causative bacteria. Associated factors were multifactorial and preventive care would be ideal to reduce the number of CRBSI based on these findings.

背景和目的：导管相关性血流感染（CRBSI）是一种危及生命的血液透析并发症。它会造成严重的发病率和死亡率以及昂贵的长时间住院。尽管其负担沉重，但人们对其相关因素及其致病细菌的抗生素谱知之甚少。本研究旨在评估血液透析CRBSI的决定因素，以及在KCMC血液透析病房就诊的患者中分离的细菌病原体的适当抗生素谱。方法：一项以医院为基础的回顾性分析横断面研究，涉及2021年1月1日至2022年12月31日在KCMC使用隧道式或非隧道式中心静脉导管进行血液透析的成年CKD或AKI患者。数据是从医院的电子病历系统中收集的。采用SPSS 27版进行统计分析。采用多因素logistic回归确定与CRBSI相关的因素。结果的p值：共分析286例患者。患者以男性为主（70.6%），55岁以上占一半以上（56%），平均年龄58 （SD±14.8）岁。56.6%发生CRBSI，主要为革兰氏阳性（69.7%）。结论：超过50%的患者发生CRBSI，革兰氏阳性菌为主要致病菌。相关因素是多因素的，基于这些发现，预防性护理将是减少CRBSI数量的理想选择。

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引用次数: 0

Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross-Sectional Study 肯尼亚肯雅塔国家医院新生儿脓毒症住院时间的预测因素：一项前瞻性横断面研究。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports

Pub Date : 2025-01-13 DOI: 10.1002/hsr2.70344

Athman Khaltuma Tisho, Patrick Mwirigi Mbugua, Rose Bosire, Simon Muturi Karanja

Background and Aims

Neonatal sepsis is a major cause of neonatal mortality worldwide. It remains a detrimental bottleneck to the WHO goal of eradicating preventable deaths for children below 5 years of age by 2030. Though the risk factors for adverse clinical outcomes for neonatal sepsis have been widely studied there is no universal consensus. Length of hospitalization is considered an indicator for adverse clinical outcome of neonatal sepsis. Markedly, literature is scarce regarding the drivers of extended hospitalization for neonatal sepsis in Kenya.

Methodology

This study determined the predictors of prolonged hospital stay for neonatal sepsis at the pediatric wards, KNH, Kenya. This was prospective cross-sectional research carried out among 314 mother/neonate pairs. The neonates were confirmed to have sepsis. Logistic regression analysis was conducted to determine maternal and neonate status predictive of duration of hospitalization.

Results

The median duration of hospital stay was 11 days and the majority (52.9%) were hospitalized for more than 11 days. The findings identified that maternal age ≥ 35 years (OR = 3.72, 95% CI: 1.61–8.59, p = 0.03), UTI during pregnancy (OR = 1.82, 95% CI: 1.07–3.11, p = 0.03), not breastfeeding (OR = 2.31, 95% CI: 1.29–4.14, p = 0.005), convulsion (OR = 2.03, 95% CI: 1.22–3.37, p = 0.01), jaundice (OR = 1.45, 95% CI: 1.10–1.91, p = 0.002), reduced movements (OR = 1.72, 95% CI: 1.08–2.72, p = 0.02), low birthweight (OR = 6.1, 95% CI: 2.48–14.99, p < 0.001) and preterm birth (OR = 3.1, 95% CI: 1.64–5.86, p < 0.001) were significant predictors of longer hospital stay.

Conclusion

The findings provide insights into the factors that can be monitored to predict the prognosis of neonatal sepsis. Besides, remedies can target these variables to mitigate prolonged hospitalization and severity of neonatal sepsis.

背景和目的：新生儿败血症是全世界新生儿死亡的主要原因。它仍然是世卫组织到2030年消除5岁以下儿童可预防死亡的目标的一个有害瓶颈。虽然新生儿败血症不良临床结局的危险因素已被广泛研究，但尚未达成普遍共识。住院时间被认为是新生儿败血症不良临床结局的一个指标。显然，文献很少关于延长住院治疗新生儿败血症在肯尼亚的驱动因素。方法：本研究确定了在肯尼亚KNH儿科病房延长新生儿败血症住院时间的预测因素。这是一项对314对母亲/新生儿进行的前瞻性横断面研究。新生儿确诊为败血症。进行Logistic回归分析以确定产妇和新生儿状态对住院时间的预测。结果：患者住院时间中位数为11 d，超过11 d的占52.9%。研究结果发现,母亲的年龄≥35年(OR = 3.72, 95% CI: 1.61—-8.59,p = 0.03),泌尿道感染在怀孕期间(OR = 1.82, 95% CI: 1.07—-3.11,p = 0.03),没有母乳喂养(OR = 2.31, 95% CI: 1.29—-4.14,p = 0.005),痉挛(OR = 2.03, 95% CI: 1.22—-3.37,p = 0.01),黄疸(OR = 1.45, 95% CI: 1.10—-1.91,p = 0.002),减少运动(OR = 1.72, 95% CI: 1.08—-2.72,p = 0.02),低出生体重(OR = 6.1, 95% CI: 2.48—-14.99,p p结论:研究结果提供了洞察的因素，可以监测预测新生儿败血症的预后。此外，补救措施可以针对这些变量，以减轻长期住院治疗和新生儿败血症的严重程度。

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引用次数: 0