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Scheduling-Based Transmit Signal Shaping in Energy-Constrained Molecular Communications 能量受限分子通信中基于调度的传输信号整形
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-11-08 DOI: 10.1109/TMBMC.2023.3329801
Mustafa Can Gursoy;Urbashi Mitra
Diffusion-based molecular communications (DBMC) systems rely on diffusive propagation of molecules to convey information. In a DBMC system, as each emitted molecule experiences a stochastic delay, pulse shaping is crucial for a DBMC system’s reliability and overall performance. To this end, acknowledging the inherent resource-limited nature of a DBMC system, a novel framework to model and optimize a DBMC transmitter is introduced in this paper. Leveraging tools from wireless packet scheduling theory, the DBMC pulse shaping problem is formulated as an energy-constrained resource allocation problem. Through the developed framework, it is shown that the provably optimal pulse shape that minimizes the error probability is the delayed-spike pulse, where the incurred delay is a decreasing function of the available energy budget. The framework is then extended to both absorbing and passive/observing receiver structures, as well as systems where molecules can degrade in the transmitter body prior to release. Numerical results corroborate the developed analysis, and show that the delayed-spike outperforms conventional, non-zero-width pulse shapes in terms of error performance.
基于扩散的分子通信(DBMC)系统依靠分子的扩散传播来传递信息。在 DBMC 系统中,由于每个发射的分子都会经历随机延迟,因此脉冲整形对 DBMC 系统的可靠性和整体性能至关重要。为此,考虑到 DBMC 系统固有的资源有限性,本文引入了一个新颖的框架来模拟和优化 DBMC 发射器。利用无线数据包调度理论的工具,DBMC 脉冲整形问题被表述为一个能量受限的资源分配问题。通过所开发的框架,可以证明误差概率最小的最佳脉冲形状是延迟尖峰脉冲,其中产生的延迟是可用能量预算的递减函数。该框架随后被扩展到吸收式和被动/观测式接收器结构,以及在释放前分子会在发射器体内降解的系统。数值结果证实了所做的分析,并表明延迟尖峰在误差性能方面优于传统的非零宽度脉冲形状。
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引用次数: 0
Channel Characterization of Molecular Communications for Cytokine Storm in COVID-19 Patients COVID-19 患者细胞因子风暴分子通讯的通道特征
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-10-26 DOI: 10.1109/TMBMC.2023.3327869
Saswati Pal;Sudip Misra;Nabiul Islam;Sasitharan Balasubramaniam
In the most severe COVID-19 cases, often the cytokine molecules produced by the immune system to fight off coronavirus infection become hyperactive. This leads to “cytokine storm”, which is a serious adverse medical condition causing multiple organ failures. In this work, we propose a system model that captures the transmission of cytokines from the alveoli, the propagation via the vascular channel, and the reception in the blood vessel wall. We analyze the impact of different diseases on induced cytokine storm. The proposed analytical model helps observe the behavior of cytokine storm in different medical conditions. We perform particle-based simulations to analyze the proposed end-to-end channel model describing the cytokine storm in terms of gain and delay, which is inspired from the existing molecular communication channel models from literature. We observe that the channel gain mostly remains unaffected for upto three times increase in the channel length, while, with four times increase, the gain increases upto 16% at 1000 rad/s frequency. We analyze the channel response to the different stimuli of interactions between the cytokines and their varying release rates. We evaluate the cytokine signal at the receiver and observe that lesser diffusion leads to higher cytokine concentration at the receiver.
在最严重的 COVID-19 病例中,免疫系统为抵御冠状病毒感染而产生的细胞因子分子往往变得异常活跃。这将导致 "细胞因子风暴",而 "细胞因子风暴 "是一种严重的不良医疗状况,会导致多个器官衰竭。在这项工作中,我们提出了一个系统模型,该模型捕捉了细胞因子从肺泡传播、通过血管通道传播以及在血管壁接收的过程。我们分析了不同疾病对诱发细胞因子风暴的影响。所提出的分析模型有助于观察细胞因子风暴在不同病症下的行为。我们从现有的分子通讯信道模型中汲取灵感,以粒子为基础进行仿真,分析了从增益和延迟角度描述细胞因子风暴的端到端信道模型。我们观察到,在信道长度增加三倍的情况下,信道增益大多不受影响,而在频率为 1000 rad/s 的情况下,信道长度增加四倍时,增益最多可增加 16%。我们分析了通道对细胞因子之间相互作用的不同刺激及其不同释放率的响应。我们对接收器中的细胞因子信号进行了评估,发现较小的扩散会导致接收器中细胞因子浓度较高。
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引用次数: 0
Terahertz Induced Protein Interactions in a Random Medium 随机介质中的太赫兹诱导蛋白质相互作用
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-10-24 DOI: 10.1109/TMBMC.2023.3327302
Hadeel Elayan;Andrew W. Eckford;Raviraj S. Adve
Folding of proteins into their correct native structure is key to their function. Simultaneously, the intricate interplay between cell movement and protein conformation highlights the complex nature of cellular processes. In this work, we demonstrate the impact of Terahertz (THz) signaling on controlling protein conformational changes in a random medium. Our system of interest consists of a communication link that involves a nanoantenna transmitter, a protein receiver, and a channel composed of moving red blood cells. Due to the system dynamics, we investigate the influence of both the fast and slow channel variations on protein folding. Specifically, we analyze the system’s selectivity to asses the effectiveness of the induced THz interaction in targeting a specific group of proteins under fading conditions. By optimizing the selectivity metric with respect to the nanoantenna power and frequency, it is possible to enhance the controllability of protein interactions. Our probabilistic analysis provides a new perspective regarding electromagnetically triggered protein molecules, their micro-environment and their interaction with surrounding particles. It helps elucidate how external conditions impact the protein folding kinetics and pathways. This results in not only understanding the mechanisms underlying THz-induced protein interactions but also engineering these still-emerging tools.
蛋白质折叠成正确的原生结构是其发挥功能的关键。同时,细胞运动与蛋白质构象之间错综复杂的相互作用凸显了细胞过程的复杂性。在这项工作中,我们展示了太赫兹(THz)信号对控制随机介质中蛋白质构象变化的影响。我们感兴趣的系统由一个通信链路组成,其中包括一个纳米天线发射器、一个蛋白质接收器和一个由移动的红细胞组成的通道。由于系统是动态的,我们研究了快速和慢速信道变化对蛋白质折叠的影响。具体来说,我们分析了系统的选择性,以评估在衰减条件下,诱导太赫兹相互作用针对特定蛋白质组的有效性。通过优化与纳米天线功率和频率相关的选择性指标,可以增强蛋白质相互作用的可控性。我们的概率分析为电磁触发蛋白质分子、其微环境及其与周围粒子的相互作用提供了一个新的视角。它有助于阐明外部条件如何影响蛋白质折叠动力学和路径。这不仅有助于了解太赫兹诱导蛋白质相互作用的基本机制,还有助于对这些仍在新兴的工具进行工程化。
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引用次数: 0
Channel Parameter Studies of a Molecular Communication Testbed With Biocompatible Information Carriers: Methods and Data 使用生物兼容信息载体的分子通信试验台的信道参数研究:方法与数据
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-10-19 DOI: 10.1109/TMBMC.2023.3325405
Max Bartunik;Janina Teller;Georg Fischer;Jens Kirchner
Testbeds play an essential role in the development of real-life molecular communication applications and experimental validation of communication channel models. Although some testbed concepts have been published in recent years, very few setups are inherently suitable for biomedical applications. Furthermore, systematic experimental data of a wide parameter field for molecular communication is scarce and often difficult to generate. In this work, a biocompatible testbed for molecular communication with magnetic nanoparticles is used to investigate a series of transmission channel parameters. The observed results are discussed in the context of a laminar flow channel. All experimental data regarding the parameter studies as well as an additional data set for a large binary transmission sequence is provided as a supplement to this publication. The data is available on a public server to allow for further use by other researchers.
在开发现实生活中的分子通信应用和通信信道模型的实验验证方面,试验台起着至关重要的作用。虽然近年来已经发布了一些试验台概念,但适合生物医学应用的试验台却很少。此外,分子通讯广泛参数领域的系统性实验数据非常稀少,而且往往难以生成。在这项工作中,利用磁性纳米粒子分子通讯的生物兼容试验台研究了一系列传输通道参数。观察到的结果将在层流通道的背景下进行讨论。有关参数研究的所有实验数据以及大型二元传输序列的附加数据集作为本出版物的补充。这些数据可在公共服务器上获取,以便其他研究人员进一步使用。
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引用次数: 0
Deterministic Identification for Molecular Communications Over the Poisson Channel 泊松信道上分子通信的确定性识别
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-10-13 DOI: 10.1109/TMBMC.2023.3324487
Mohammad Javad Salariseddigh;Vahid Jamali;Uzi Pereg;Holger Boche;Christian Deppe;Robert Schober
Various applications of molecular communications (MC) are event-triggered, and, as a consequence, the prevalent Shannon capacity may not be the right measure for performance assessment. Thus, in this paper, we motivate and establish the identification capacity as an alternative metric. In particular, we study deterministic identification (DI) for the discrete-time Poisson channel (DTPC), subject to an average and a peak molecule release rate constraint, which serves as a model for MC systems employing molecule counting receivers. It is established that the number of different messages that can be reliably identified for this channel scales as $2^{(nlog n)R}$ , where ${n}$ and ${R}$ are the codeword length and coding rate, respectively. Lower and upper bounds on the DI capacity of the DTPC are developed. The obtained large capacity of the DI channel sheds light on the performance of natural DI systems such as natural olfaction, which are known for their extremely large chemical discriminatory power in biology. Furthermore, numerical results for the empirical miss-identification and false identification error rates are provided for finite length codes. This allows us to characterize the behaviour of the error rate for increasing codeword lengths, which complements our theoretically-derived scale for asymptotically large codeword lengths.
分子通信(MC)的各种应用都是由事件触发的,因此,流行的香农容量可能不是性能评估的正确指标。因此,在本文中,我们提出并确立了识别能力作为替代指标。特别是,我们研究了离散时间泊松信道(DTPC)的确定性识别(DI),该信道受平均分子释放率和峰值分子释放率的限制,可作为采用分子计数接收器的 MC 系统的模型。研究证明,在该信道中可以可靠识别的不同信息的数量为 $2^{(nlog n)R}$ ,其中 ${n}$ 和 ${R}$ 分别为码字长度和编码率。本文提出了 DTPC 的 DI 容量的下限和上限。DI 信道所获得的大容量揭示了自然 DI 系统(如自然嗅觉)的性能,众所周知,自然嗅觉在生物学中具有极强的化学判别能力。此外,我们还提供了有限长度编码的经验误识别率和误识别错误率的数值结果。这使我们能够描述误码率在码字长度增加时的表现,从而补充了我们从理论上推导出的渐近大码字长度的规模。
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引用次数: 0
Area Rate Efficiency in Multi-Link Molecular Communications 多链路分子通信中的区域速率效率
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-10-02 DOI: 10.1109/TMBMC.2023.3321193
Lukas Brand;Sebastian Lotter;Vahid Jamali;Robert Schober;Maximilian Schäfer
We consider a multi-link diffusion-based molecular communication (MC) system where multiple spatially distributed transmitter (TX)-receiver (RX) pairs establish point-to-point communication links employing the same type of signaling molecules. To exploit the full potential of such a system, an in-depth understanding of the interplay between the spatial link density and inter-link interference (ILI) and its impact on system performance is needed. In this paper, we consider a three-dimensional unbounded domain with multiple spatially distributed point-to-point non-cooperative transmission links, where both the TXs and RXs are positioned on a regular fixed grid. For this setup, we first derive an analytical expression for the channel impulse responses (CIRs) between the TXs and RXs in the system. Then, we derive the maximum likelihood (ML) detector for the RXs and show that it reduces to a threshold-based detector. Moreover, we derive an analytical expression for the corresponding detection threshold which depends on the statistics of the desired signal from the dedicated TX, the statistics of the MC channel, and the statistics of the ILI. We also provide a low-complexity suboptimal decision threshold. Furthermore, we derive an analytical expression for the bit error rate (BER) and the achievable rate of a single transmission link. Finally, we propose two new performance metrics, namely area rate efficiency (ARE) and area and time rate efficiency (ARTE), suitable for holistically evaluating spatially distributed multi-link MC systems. In particular, ARE and ARTE capture the tradeoff between transmission link density and achievable rate per link and the tradeoff between transmission link density, achievable rate per link, and inter-symbol interference (ISI), respectively. Hence, ARE and ARTE can be exploited to determine the optimal transmission link density for maximizing the throughput of the entire system.
我们考虑了一种基于多链路扩散的分子通信(MC)系统,在该系统中,多个空间分布的发射器(TX)-接收器(RX)对利用同类信号分子建立点对点通信链路。为了充分发挥这种系统的潜力,需要深入了解空间链路密度和链路间干扰(ILI)之间的相互作用及其对系统性能的影响。在本文中,我们考虑了一个具有多个空间分布式点对点非合作传输链路的三维无界域,其中发送端和接收端都位于一个规则的固定网格上。对于这种设置,我们首先推导出系统中发射机和接收机之间信道脉冲响应(CIR)的解析表达式。然后,我们推导出 RX 的最大似然 (ML) 检测器,并证明它可以简化为基于阈值的检测器。此外,我们还推导出了相应检测阈值的解析表达式,该阈值取决于专用 TX 的期望信号统计量、MC 信道统计量和 ILI 统计量。我们还提供了一个低复杂度的次优决策阈值。此外,我们还推导出了单个传输链路的误码率 (BER) 和可实现速率的分析表达式。最后,我们提出了两个新的性能指标,即区域速率效率(ARE)和区域与时间速率效率(ARTE),适用于整体评估空间分布式多链路 MC 系统。其中,ARE 和 ARTE 分别捕捉了传输链路密度和每个链路的可实现速率之间的权衡,以及传输链路密度、每个链路的可实现速率和符号间干扰(ISI)之间的权衡。因此,可以利用 ARE 和 ARTE 来确定最佳传输链路密度,从而最大限度地提高整个系统的吞吐量。
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引用次数: 0
IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Publication Information IEEE分子、生物学和多尺度通信出版信息汇刊
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-09-19 DOI: 10.1109/TMBMC.2023.3292628
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引用次数: 0
Guest Editorial Introduction to the Special Feature on the 7th Workshop on Molecular Communications 第七届分子通讯研讨会特稿客座编辑介绍
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-09-19 DOI: 10.1109/TMBMC.2023.3309471
Vahid Jamali;Falko Dressler;Yifan Chen;Maximilian Schäfer;Robert Schober
Molecular Communication (MC) is a highly interdisciplinary research field whose success requires the close collaboration between researchers from different fields of science. To support and highlight this interdisciplinary character, the Workshop on Molecular Communications (MolCom; https://molecularcommunications.org/) has been held annually since 2016 to provide the opportunity to meet, and share work and experience. The Workshop tries to promote research beyond the conventional disciplinary boundaries between engineering, the physical sciences, natural sciences, and medicine.
分子通讯是一个高度跨学科的研究领域,其成功需要来自不同科学领域的研究人员之间的密切合作。为了支持和强调这一跨学科性质,分子通讯讲习班(MolCom;https://molecularcommunications.org/)自2016年以来,每年都会举办一次,以提供见面、分享工作和经验的机会。该讲习班试图推动超越工程、物理科学、自然科学和医学之间传统学科界限的研究。
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引用次数: 0
IEEE Communications Society Information IEEE通信协会信息
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-09-19 DOI: 10.1109/TMBMC.2023.3292630
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引用次数: 0
Guest Editorial Special Feature on Bio-Chem-ICTs: Synergies Between Bio/Nanotechnologies and Molecular Communications 生物化学信息通信技术客座编辑特辑:生物/纳米技术与分子通信之间的协同作用
IF 2.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-09-19 DOI: 10.1109/TMBMC.2023.3309488
Murat Kuscu;Pasquale Stano;Malcolm Egan;Michael T. Barros;Bige Deniz Unluturk;Gregory F. Payne
The Transfer of ‘information’ via molecules is a theme that resonates across the realm of nature, underlying collective behavior, homeostasis, and many disorders and diseases, and potentially holding the answers to some of the life’s most profound questions. The prospects of understanding and manipulating this natural modality of communication have attracted a significant research interest from information and communication theorists (ICT) over the past two decades. The aim is to provide novel means of understanding and engineering biological systems. These efforts have produced substantial body of literature that sets the groundwork for bio-inspired, artificial Molecular Communication (MC) systems. This ICT-based perspective has also contributed to the understanding of natural MC, with many of the results from these endeavors being published in this journal.
通过分子传递“信息”是一个在自然界、潜在的集体行为、体内平衡和许多疾病领域引起共鸣的主题,并可能为生活中一些最深刻的问题找到答案。在过去的二十年里,理解和操纵这种自然的通信方式的前景吸引了信息和通信理论家的极大研究兴趣。其目的是提供理解和工程化生物系统的新方法。这些努力产生了大量的文献,为生物启发的人工分子通信(MC)系统奠定了基础。这种基于信息和通信技术的观点也有助于理解自然MC,这些努力的许多结果发表在本杂志上。
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引用次数: 0
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IEEE Transactions on Molecular, Biological, and Multi-Scale Communications
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