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Dielectric Properties of Ni-Co Nanoferrites Synthesized using GreenSynthesis Process 采用绿色合成工艺合成的镍钴纳米铁氧体的介电性能
Pub Date : 2023-12-04 DOI: 10.2174/0126661454279603231113165113
Neetu Dhanda, P. Thakur, A. Thakur
A series of nickel doped cobalt (NixCo1-xFe2O4, x=0.0 to 1.0) were successfully synthesized using green synthesized process.Tensile strain of all positive slope samples observed from the W-H (WilliamsonHall) plot. It was discovered that as Ni-substitution increased, the dielectric constant (є’) increased from 148.07 to 243.62. Conversely, when the amount of Ni-substitution increases, thedielectric loss (tan δ from 0.23 to 0.05), imaginary part (є’’ from 98.81 to 17.87), and ac conductivity (σac from 1.62 to 0.15) all decreases at 1MHz frequency.The purpose of current work is to investigate Williamson Hall effect and dielectric properties to find out the effects of nickel doping on the vibrational mode and crystal structure of cobalt ferrite.This demonstrates that when Ni-substitution increases, energy losses at high frequencies decrease. Dielectric constant and ac conductivity, of all samples act in accordance withKoop's theory, the Maxwell-Wagner polarization procedure, and electron hoppingThis makes them suitable materials for high-frequency applications
采用绿色合成方法成功合成了一系列镍掺杂钴(NixCo1-xFe2O4, x=0.0 ~ 1.0)。从W-H (WilliamsonHall)图中观察到的所有正斜率样品的拉伸应变。发现随着ni取代量的增加,介电常数(n′)从148.07增加到243.62。相反,随着ni取代量的增加,在1MHz频率下,介质损耗(tan δ从0.23增加到0.05)、赝部(n′从98.81增加到17.87)和交流电导率(σac从1.62增加到0.15)均降低。本工作的目的是研究Williamson Hall效应和介电性能,以了解镍掺杂对钴铁氧体的振动模式和晶体结构的影响。这表明,当镍取代增加时,高频能量损失减少。所有样品的介电常数和交流电导率都符合koop理论,麦克斯韦-瓦格纳极化过程和电子跳变,这使它们成为高频应用的合适材料
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引用次数: 0
Compatibility and Thermal Decomposition Kinetics of Hexahydro-1,3,5-trinitro-1,3,5-triazine with Different Polyester-based Polyurethanes 六氢-1,3,5-三硝基-1,3,5-三嗪与不同聚酯基聚氨酯的兼容性和热分解动力学
Pub Date : 2023-12-04 DOI: 10.2174/0126661454271269231114130046
Rajesh Kumar, Arjun Singh, Prateek Kishor, P. Thakur, P. Soni, A. Thakur
The compatibility study is an important aspect beforepre-formulation of the energetic composites. Any sort of the incompatibilitybetween the ingredients of the energetic composites greatly affects the safetyand functionality of the energetic composites. Therefore, to develope saferenergetic composites, the compatibility between the different ingredients of theenergetic formulations and their thermal decomposition kinetics is importantstudy as it is directly linked with the safety and functionality of the energetic composites.The compatibility of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) withdifferent polyester-based polyurethanes (PUs) were studied by using vacuum stabilitytester (VST) and differential scanning calorimetry (DSC) methods as outlined byNorth Atlantic Treaty Organisation Standardisation Agreement (STANAG 4147).The mixture of RDX with polyester-based PUs was cured with MDI (4,4’-methylenediphenyl diisocyanate), IPDI (isophorone diisocyanate) and TMDI (2,2,4-trimethylhexamethylene diisocyanate) as curatives to get polyester-based PUs. TheVST measurements were carried out at isothermal temperature of 100℃ for 40 h. Forkinetic study, all the samples were subjected to heat from 25-600℃ at different heating rates under flow rate of nitrogen gas of 40 mL/minThe VST results revealed that energetic RDX was compatible with all polyester-based PUs and was chemically stable. The thermal decomposition behaviourwas studied by employing thermogravimetric analysis (TGA) and DSC. The DSC results indicated that peak temperature difference (∆Tp) between pure RDX and binarymixture of RDX and polyester-based PUs i.e., RDX/PE/MDI, RDX/PE/IPDI andRDX/PE/TMDI were found to be greater than 4℃, indicating that RDX was not compatible with all types polyester-based PUs. The thermal stability in terms of Tmax values of RDX/PE/MDI, RDX/PE/IPDI and RDX/PE/TMDI was found to be significantly reduced as compared to pure RDX. The activation energy obtained by the Kissinger method for RDX/PE/MDI, RDX/PE/IPDI and RDX/PE/TMDI samples was foundto be 220.2, 271.5 and 210.4 kJ/mol, respectively. The experimental results showedthat the values are comparable and in good agreement with the values obtained byOzawa method.This study provides useful information for selecting polyester-based PUs as polymeric binder for the preparation of RDX-based energeticcomposites.
相容性研究是含能复合材料预配制前的一个重要方面。高能复合材料各成分之间的任何一种不相容都极大地影响着高能复合材料的安全性和功能性。因此,为了开发更安全的含能复合材料,研究含能配方中不同成分之间的相容性及其热分解动力学是很重要的,因为它直接关系到含能复合材料的安全性和功能性。根据北大西洋公约组织标准化协议(STANAG 4147),采用真空稳定性测试仪(VST)和差示扫描量热法(DSC)研究了六氢-1,3,5-三硝基-1,3,5-三嗪(RDX)与不同聚酯基聚氨酯(pu)的相容性。以MDI(4,4′-亚甲基二苯基二异氰酸酯)、IPDI(异福尔酮二异氰酸酯)和TMDI(2,2,4-三甲基六亚甲基二异氰酸酯)为固化剂固化RDX -聚酯基pu,得到聚酯基pu。在100℃的等温条件下进行了40 h的VST测量,在40 mL/min的氮气流速下进行了25 ~ 600℃的不同加热速率的VST研究,结果表明RDX与所有聚酯基pu兼容,化学性质稳定。采用热重分析(TGA)和差热分析(DSC)对其热分解行为进行了研究。DSC结果表明,纯RDX与RDX与聚酯基pu的二元混合物(RDX/PE/MDI、RDX/PE/IPDI和RDX/PE/TMDI)的峰值温差(∆Tp)均大于4℃,表明RDX与所有类型的聚酯基pu均不相容。与纯RDX相比,RDX/PE/MDI、RDX/PE/IPDI和RDX/PE/TMDI的热稳定性Tmax值明显降低。RDX/PE/MDI、RDX/PE/IPDI和RDX/PE/TMDI的活化能分别为220.2、271.5和210.4 kJ/mol。实验结果表明,所得结果与小泽法所得结果具有较好的可比性和一致性。该研究为选择聚酯基pu作为聚合粘合剂制备rdx基能量复合材料提供了有益的信息。
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引用次数: 0
Cyclic Voltammetry and Photoluminescence Studies of Ag-doped ZnO Nanoparticles ag掺杂ZnO纳米颗粒的循环伏安法和光致发光研究
Pub Date : 2023-11-09 DOI: 10.2174/0126661454269682231024165319
Amitender Singh, Kavita Yadav, Preeti Thakur, Atul Thakur
Aims: Synthesis of Zinc oxide (ZnO) and silver (Ag) doped ZnO nanoparticles (NPs) using simple, fast, effective and economic co-precipitation method and study of Cyclic Voltammetry and Photoluminescence characteristics. Background: Herein, we prepared Zinc oxide (ZnO) and silver (Ag) doped ZnO nanoparticles (NPs) using simple, fast, effective and economic co-precipitation method. The superior surface characteristics and antibacterial effects in the nanoscale range of ZnO encourage us to work on the ZnO NPs. Also, Ag has long been employed for its antibacterial qualities. X-ray diffraction (XRD) results show that ZnO NPs show hexagonal phase and additional peak obtained with Ag doping in ZnO. Photoluminescence (PL) spectroscopy is being used for the investigation of electronic structure and defects in NPs. According to the PL study, Ag doping results in a decrease in the intensity of near band edge emission (NBE) and enhanced intensity of broad visible emission (BVE) with Ag doping in ZnO. Measurements from cyclic voltammetry (CV) demonstrate approximately symmetric peaks which are related with anodic and cathodic behaviors of the NPs based electrode. It is found that the peak separation increases with Ag doping in ZnO, which could be associated with the variations in the transfer of electrons at the interface between working electrode and the solution. Since peak potentials in the case of ZnO and Ag-ZnO are totally different which confirm the incorporation of Ag doping into ZnO NPs. Enhancement in the cathodic peaks with silver doping clarifies that number of electrons incorporated into photocatalysis process enhance with each repeated cycle, confirming an increase in the reaction activity of Ag-ZnO NPs. The obtained results indicate that Ag doped ZnO NPs may find application as efficient photocatalytic material. Objective: Synthesis of Zinc oxide (ZnO) and silver (Ag) doped ZnO nanoparticles (NPs) using simple, fast, effective and economic co-precipitation method. Study of Cyclic Voltammetry and Photoluminescence characteristics. Method: Simple, fast, effective and economic chemical co-precipitation method is used for synthesis of nanoparticles. Result: According to the PL study, Ag doping results in a decrease in the intensity of near band edge emission (NBE) and enhanced intensity of broad visible emission (BVE) with Ag doping in ZnO. Measurements from cyclic voltammetry (CV) demonstrate approximately symmetric peaks which are related with anodic and cathodic behaviours of the NPs based electrode. It is found that the peak separation increases with Ag doping in ZnO, which could be associated with the variations in the transfer of electrons at the interface between working electrode and the solution. Since peak potentials in the case of ZnO and Ag-ZnO are totally different which confirm the incorporation of Ag doping into ZnO NPs. Enhancement in the cathodic peaks with silver doping clarifies that number of electrons incorporated into photocata
目的:采用简单、快速、有效、经济的共沉淀法合成氧化锌(ZnO)和银(Ag)掺杂ZnO纳米粒子(NPs),并研究其循环伏安法和光致发光特性。背景:本文采用简单、快速、有效、经济的共沉淀法制备氧化锌和银掺杂ZnO纳米粒子。氧化锌优异的表面特性和纳米级的抗菌效果促使我们对氧化锌纳米粒子进行研究。此外,银因其抗菌特性而被长期使用。x射线衍射(XRD)结果表明,在ZnO中掺杂Ag后,ZnO纳米粒子呈六方相,并形成附加峰。光致发光(PL)光谱技术被用于研究NPs的电子结构和缺陷。根据PL研究,Ag掺杂导致ZnO近带边缘发射强度(NBE)降低,宽可见发射强度(BVE)增强。循环伏安法(CV)的测量表明,NPs基电极的阳极和阴极行为近似对称。结果表明,银在ZnO中的掺杂增加了峰分离,这可能与工作电极与溶液界面处电子转移的变化有关。由于ZnO和Ag-ZnO的峰电位完全不同,这证实了ZnO纳米粒子中掺杂了Ag。银掺杂后阴极峰的增强表明,随着每个重复循环,加入光催化过程的电子数量增加,证实了Ag-ZnO NPs的反应活性增加。结果表明,Ag掺杂ZnO纳米粒子可以作为高效的光催化材料。目的:采用简单、快速、有效、经济的共沉淀法合成氧化锌(ZnO)和银(Ag)掺杂ZnO纳米粒子(NPs)。循环伏安法和光致发光特性的研究。方法:采用简单、快速、有效、经济的化学共沉淀法合成纳米颗粒。结果:根据PL研究,Ag掺杂导致ZnO近带边缘发射强度(NBE)降低,宽可见发射强度(BVE)增强。循环伏安法(CV)的测量表明,NPs电极的阳极和阴极行为与近似对称的峰有关。结果表明,银在ZnO中的掺杂增加了峰分离,这可能与工作电极与溶液界面处电子转移的变化有关。由于ZnO和Ag-ZnO的峰电位完全不同,这证实了ZnO纳米粒子中掺杂了Ag。银掺杂后阴极峰的增强表明,随着每个重复循环,加入光催化过程的电子数量增加,证实了Ag-ZnO NPs的反应活性增加。结论:银掺杂ZnO纳米粒子具有良好的光催化性能和抗菌性能。
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引用次数: 0
Investigation of Development of Phonology using Artificial Intelligence: A Preliminary Study 利用人工智能对音韵学发展的调查:初步研究
Pub Date : 2023-11-06 DOI: 10.2174/0126661454266606231020074225
Vijay Kumar, Anjani Jain, Jitendra Kumar Saini, Leena Bhardwaj
Background: Investigation of the development of acquisition of phonological processes is a very important phenomenon to predict language development in childhood. Phonological development refers to the gradual acquisition of an adult-like speech system used to convey meaning in a language. Adequate phonological development can lead to higher speech intelligibility, essential for perception and speech production. The test battery approach for phonological assessment includes formal as well as informal testing modalities. Speech intelligibility is a vital parameter for the assessment of phonological development. This is done via scoring collected audio speech samples, followed by IPA transcription and scoring and analysis of data manually. The primary objective of the study was to investigate the speech intelligibility score across real-timed stimuli (rhyming, storytelling, open-ended questions, and picture description tasks) across two age categories, i.e., 3-4 and 4-5 years among 40 Hindi-speaking children. Methods: A total of 40 children (15 girls and 25 boys) in the age range of 3 to 5 years were randomly selected from a junior high school in New Delhi, India. Groupwise speech intelligibility score was calculated for rhyming, storytelling, open-ended questions, and picture description tasks. Results: It was observed that the speech intelligibility score for open-ended questions was significantly higher in the 4-5 years group (94.09 ± 3.7) than the 3-4 years (89.83 ± 8.2), t (1, 38) =2.12, p =0.04). However, no significant improvement in rhyming task [t (1, 38) =1.14, p =0.18), storytelling [t (1, 38) =1.81, p =0.07), and picture description [t (1, 38) =1.89, p =0.06) was observed. Conclusion: Chances of error in conventional method of phonology assessment still persists which may be controlled using Artificial Intelligence (AI). The target phonetic stimulus can be customized based on the linguistic experience and environment.
背景:语音过程习得的发展是预测儿童语言发展的一个重要现象。语音发展是指逐渐获得一种类似成人的语言系统,用来表达语言的意思。充分的语音发展可以导致更高的语音清晰度,这对感知和语音产生至关重要。语音评估的测试单元方法包括正式和非正式的测试方式。语音可理解度是评估语音发展的重要参数。这是通过对收集到的音频语音样本进行评分,然后手动进行国际音标转录和数据评分和分析来完成的。本研究的主要目的是调查40名印地语儿童在实时刺激(押韵、讲故事、开放式问题和图片描述任务)下的语音清晰度得分,这些语音清晰度得分跨越两个年龄类别,即3-4岁和4-5岁。方法:在印度新德里一所初中随机抽取年龄在3 ~ 5岁的儿童40名,其中女孩15名,男孩25名。计算了押韵、讲故事、开放式问题和图片描述任务的群体语音清晰度得分。结果:4-5岁组开放式问题语音清晰度得分(94.09±3.7)明显高于3-4岁组(89.83±8.2),t (1,38) =2.12, p =0.04)。然而,在押韵任务[t (1,38) =1.14, p =0.18]、讲故事任务[t (1,38) =1.81, p =0.07]和图片描述任务[t (1,38) =1.89, p =0.06]方面没有显著改善。结论:传统的音系评估方法仍然存在误差,可以通过人工智能(AI)加以控制。目标语音刺激可以根据语言经验和环境进行定制。
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引用次数: 0
Chitosan Biopolymer As Sustainable Material For Chromium Removal From Waste Water Bodies 壳聚糖生物聚合物在废水脱铬中的可持续应用
Pub Date : 2023-10-25 DOI: 10.2174/0126661454248025230919055029
Seema Lal, Shilpi Bhatnagar
Abstract: Rapid industrialization by humans is a dominant source of waste materials in water bodies and has created serious environmental problems, which has made the survival of life forms on land as well as in water bodies a challenge. Water gets contaminated by human waste, domestic sewage, wastewater discharges and effluents from industrial sites such as factories, refineries, and mines, accidental spills of chemicals, agricultural run-off, toxic metals and radioactive materials. The toxic nonbiodegradable chemicals in industrial waste are treated by various methods such as adsorption, coagulation, ozonation, membrane filtration, ion exchange, chemical oxidation and biological treatments. Biopolymers such as cellulose, chitosan, alginate and keratin proteins are the most sustainable, renewable and biocompatible polymers commonly used materials for wastewater purification. Chromium VI is one of the serious aquatic pollutants released as effluent from various industries and is considered a potentially toxic metal ion for humans and aquatic life. In the past decades, various conventional methods with their own merits and demerits have been explored for Cr decontamination from wastewater bodies. The present study highlights the application of Chitosan biopolymer as an effective and sustainable material for efficiently removing Cr VI metal ions from wastewater bodies.
摘要:人类的快速工业化是水体废弃物的主要来源,造成了严重的环境问题,对陆地和水体生物的生存构成了挑战。水受到人类废物、生活污水、废水排放和工厂、炼油厂和矿山等工业场所的流出物、化学品意外泄漏、农业径流、有毒金属和放射性物质的污染。工业废水中的有毒不可生物降解化学物质可通过吸附、混凝、臭氧氧化、膜过滤、离子交换、化学氧化和生物处理等多种方法进行处理。纤维素、壳聚糖、海藻酸盐和角蛋白等生物聚合物是最具可持续性、可再生和生物相容性的聚合物,是废水净化的常用材料。六价铬是各种工业废水排放的严重水生污染物之一,被认为是对人类和水生生物具有潜在毒性的金属离子。在过去的几十年里,人们探索了各种常规方法来去除废水中的铬,各有优缺点。壳聚糖生物聚合物是一种高效、可持续去除废水中六价铬金属离子的材料。
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引用次数: 0
Marine Polysaccharides for Gene Delivery: Approaches and Prospective 用于基因传递的海洋多糖:方法和前景
Pub Date : 2023-10-24 DOI: 10.2174/0126661454257825231012191447
Shubham Kumar Thakur, Priyanshi Goyal, Rishabha Malviya
Abstract: Polysaccharides from marine sources have been increasingly used in recent research due to their availability, affordability, biocompatibility, and biodegradability. These features make them promising candidates for use in nanotechnology in a wide variety of drug delivery systems, including those for gene therapy, tissue engineering, cancer therapy, wound dressing, biosensors, and water purification. Marine polysaccharides are of particular interest due to their distinct physicochemical and biological properties like chitin, alginate, carrageenan, fucoidan, and chitosan has inspired an array of nanostructures. This article summarizes the history, chemical composition, biological functions, and nanomedical uses of these marine polysaccharides. Marine polysaccharides are the topic of this review due to their potential utility in gene transfer.
摘要:海洋多糖因其可获得性、可负担性、生物相容性和生物降解性而越来越多地应用于研究中。这些特性使它们成为纳米技术广泛应用于各种药物输送系统的有希望的候选者,包括基因治疗、组织工程、癌症治疗、伤口敷料、生物传感器和水净化。海洋多糖由于其独特的物理化学和生物学特性而引起了人们的特别关注,如几丁质、海藻酸盐、卡拉胶、岩藻聚糖和壳聚糖,它们激发了一系列纳米结构的灵感。本文综述了这些海洋多糖的历史、化学成分、生物功能和纳米医学用途。海洋多糖因其在基因转移中的潜在用途而成为本综述的主题。
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引用次数: 0
An Empirical Analysis of Renewable Energy Grid Connected Supply: A Review 可再生能源并网供电的实证分析综述
Pub Date : 2023-10-24 DOI: 10.2174/0126661454245742231010060739
Md. Shahrukh Khan, Anis Ahmad, Shyamal Kumar Kundu
Abstract: A grid is an interconnected network for electricity delivery from the producer to the consumer. This review focuses on the challenges associated with the integration of renewable energy into the grid, as well as the solutions that can be used to reduce the environmental impact of climate change and achieve sustainability. Renewable energy such as solar energy, wind energy, hydroelectricity, geothermal energy, and tidal energy are the sources which can help us to achieve the reduction of CO2 emission in the atmosphere, which is directly linked to climate change and global warming. In our study, we focussed on sustainable development and decreased CO2 emissions. The grid is essentially an interconnected network for delivering electricity from the manufacturer to the consumer, and the manufacturing segment should be replaced by renewable energy for us to meet our goal.
摘要:电网是一个相互连接的网络,用于从生产者到消费者的电力输送。这篇综述的重点是与可再生能源并网相关的挑战,以及可用于减少气候变化对环境的影响和实现可持续性的解决方案。可再生能源,如太阳能、风能、水电、地热能和潮汐能,可以帮助我们实现减少大气中二氧化碳的排放,这直接关系到气候变化和全球变暖。在我们的研究中,我们关注可持续发展和减少二氧化碳排放。电网本质上是一个相互连接的网络,将电力从制造商输送到消费者,为了实现我们的目标,制造业应该被可再生能源所取代。
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引用次数: 0
Impacts of Cavity Thickness and Insulating Material on Dielectric Modulated Trench Junction-less Double Gate Field Effect Transistor for Biosensing Applications 腔厚和绝缘材料对生物传感用介电调制沟槽无结双栅场效应晶体管的影响
Pub Date : 2023-10-20 DOI: 10.2174/0126661454274311231011070702
Swagata Bhattacherjee, Palasri Dhar, Sunipa Roy
Introduction: This work represents the influence of gate dielectric, and the nano-cavity gap of a dielectric modulated trench gate Junction-less Double Gate Field Effect Transistor (JL-DGFET) on the different performance indicators is investigated considering the Low-Frequency Noise. Methods:: It is noted that the gate dielectric and the nanogap, both parameters, have a substantial influence on the sensing capacity and performance of noise of the device. Results:: A double gate suitable dielectric material and cavity thickness can effectively improve the biosensor’s sensitivity with a minimum amount of noise. Conclusion:: The sensitivity is found to increase up to 9.5 for dielectric constant, k = 3.57 and 6.5 for dielectric constant, k = 2.1.
摘要:本文研究了栅极介电介质对栅极无结双栅场效应晶体管(JL-DGFET)的影响,并在考虑低频噪声的情况下,研究了JL-DGFET的纳米腔隙对不同性能指标的影响。方法:指出栅极介电介质和纳米间隙这两个参数对器件的噪声感知能力和性能有很大的影响。结果:选择合适的双栅介质材料和腔体厚度可以有效提高生物传感器的灵敏度,同时降低噪声。结论:当介电常数k = 3.57时,灵敏度可达9.5;当介电常数k = 2.1时,灵敏度可达6.5。
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引用次数: 0
Analyzing the Response of Structural Members to Impact Loads Using Finite Element Analysis: A Review 用有限元分析分析构件对冲击荷载的响应:综述
Pub Date : 2023-10-05 DOI: 10.2174/0126661454263264230926054553
Shrikant Harle
Background: The use of Finite Element Analysis (FEA) has become widespread in simulating the response of structural members subjected to impact loads. This review paper aims to provide an overview of FEA's application for predicting the response of structural members under impact loads. Objectives: The objectives of this review are to analyze the analytical and experimental methods used for studying the dynamics of vibration and impact loads, including Finite Element Analysis, Modal Analysis, Experimental Modal Analysis, Response Spectrum Analysis, and Design of Experiments Analysis. Methods: The review paper thoroughly examines the principles of FEA, the various types of impact loads, and the different structural members involved. It analyzes the definitions, causes, effects, and analytical and experimental methods used to study vibration and impact loads. Results: The review paper highlights the significance of studying these dynamics, as failure to do so can result in catastrophic failures of structures and machines. It presents a comprehensive review of the effects of vibration and impact loads on structures and machines and the advantages and limitations of different analytical and experimental methods. Conclusion: This review provides valuable insights into the dynamics of vibration and impact loads and their potential consequences on structural integrity. The findings emphasize the importance of employing appropriate analytical and experimental methods to accurately predict and assess the response of structural members under impact loads.
背景:有限元分析(FEA)在模拟结构构件在冲击载荷作用下的响应方面已经得到了广泛的应用。本文综述了有限元分析在预测结构构件在冲击荷载作用下的响应方面的应用。目的:本综述的目的是分析用于研究振动和冲击载荷动力学的分析和实验方法,包括有限元分析、模态分析、实验模态分析、响应谱分析和实验分析设计。方法:本文深入研究了有限元分析的原理、各种类型的冲击载荷以及所涉及的不同结构构件。它分析了振动和冲击载荷的定义、原因、影响以及用于研究振动和冲击载荷的分析和实验方法。结果:这篇综述论文强调了研究这些动力学的重要性,因为不这样做可能导致结构和机器的灾难性失效。它全面回顾了振动和冲击载荷对结构和机器的影响,以及不同分析和实验方法的优点和局限性。结论:这篇综述为振动和冲击载荷的动力学及其对结构完整性的潜在影响提供了有价值的见解。研究结果强调了采用适当的分析和实验方法来准确预测和评估结构构件在冲击载荷下的响应的重要性。
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引用次数: 0
A Mini Review: Zinc Oxide NPs as a Promising Cancer Treatment Strategy: Insights into Synthesis Methodology and Mechanisms 氧化锌NPs作为一种有前景的癌症治疗策略:合成方法和机制的见解
Pub Date : 2023-09-18 DOI: 10.2174/2666145417666230918115854
Jian Xin Lim, Muhammad Nazrul Hakim Abdullah, Vuanghao Lim, Han Kee Lee, Yoke Keong Yong
Abstract: Cancer has become a major global public health concern, with millions of new cases and deaths reported annually. Conventional cancer treatments, such as chemotherapy and surgery, continue to be the standard of care; however, they frequently bear significant risks and high costs, necessitating the development of more cost-effective and safe alternatives. These limitations can be overcome by nanoparticle (NPs), composed of organic or inorganic substances in the nanoscale range, which offer benefits including enhanced pharmacokinetics, selective targeting of cancer cells, reduced toxicity, and decreased drug resistance. Green nanotechnology, which integrates nanotechnology with natural compounds, has emerged as a strategy for reducing toxicity on human health and the environment by functioning as reducing, capping, and stabilising agents. Compared to other NPs, Zinc oxide NPs (ZnO NPs) possess a unique selectivity and a potent capacity to target cancer cells, in addition to being biocompatible and considered safer for both humans and the environment. Due to the physiological function of zinc, an essential micronutrient, ZnO NPs have demonstrated greater bioavailability than other metal or metal oxide NPs. NP plays a more significant role in bioavailability than particle size, making ZnO NPs an attractive option for various applications. This mini review aims to comprehensively explore the synthesis methodology of ZnO NPs and the potential mechanisms underlying their anticancer properties. `
摘要:癌症已成为全球关注的主要公共卫生问题,每年有数百万新发病例和死亡病例报告。传统的癌症治疗,如化疗和手术,仍然是标准的治疗方法;然而,它们往往有很大的风险和高昂的费用,因此有必要开发更具成本效益和更安全的替代品。这些限制可以通过纳米颗粒(NPs)来克服,纳米颗粒由纳米级范围内的有机或无机物质组成,它提供的好处包括增强药代动力学,选择性靶向癌细胞,降低毒性和降低耐药性。绿色纳米技术将纳米技术与天然化合物结合在一起,已经成为一种战略,通过发挥减少、封顶和稳定剂的作用,减少对人类健康和环境的毒性。与其他NPs相比,氧化锌NPs (ZnO NPs)除了具有生物相容性和对人类和环境更安全外,还具有独特的选择性和靶向癌细胞的强大能力。锌是一种必需微量营养素,由于锌的生理功能,ZnO NPs比其他金属或金属氧化物NPs具有更高的生物利用度。NP在生物利用度中扮演着比粒径更重要的角色,这使得ZnO NPs成为各种应用的有吸引力的选择。本文旨在全面探讨氧化锌NPs的合成方法及其抗癌特性的潜在机制。`
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Current Materials Science
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