Current Opinion in Biomedical Engineering最新文献

英文中文

Advances in nanoparticle-mediated transdermal delivery of nucleic acids as therapy of skin disorders and cancer 纳米粒子介导的核酸经皮递送治疗皮肤病和癌症的研究进展

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-06-30 DOI: 10.1016/j.cobme.2025.100611

Fatemeh Mokhles , Juan Gonzalez-Valdivieso , Mohammad Amin Moosavi , Marco Cordani

Transdermal delivery of gene and RNA therapies represents a promising strategy in addressing genetic skin disorders and cancers, offering localized treatment with enhanced bioavailability and reduced systemic side effects. Despite these advantages, the stratum corneum presents a formidable barrier to the delivery of nucleic acids due to its dense lipid-protein structure and susceptibility to enzymatic degradation. Recent innovations in nanoparticle technologies, such as cationic liposomes and polymer-based carriers, have overcome these challenges by enhancing penetration, stability, and target specificity. Additionally, techniques like microneedles and iontophoretic applications further facilitate effective delivery into skin layers. Advanced formulations combining nanoparticles with therapeutic agents such as siRNA and CRISPR-Cas9 demonstrate significant potential in tumor growth inhibition, immune modulation, and gene correction. These approaches offer targeted therapeutic options, reduce drug resistance, and support genetic modifications for skin conditions. While challenges like immunogenicity and systemic degradation persist, emerging integration of artificial intelligence (AI) optimizes nanoparticle design and delivery systems. AI-driven advancements promise to refine transdermal delivery technologies, advancing precision medicine in dermatological applications and cancer therapy.

基因和RNA经皮给药治疗是解决遗传性皮肤病和癌症的一种很有前途的策略，它提供了具有增强生物利用度和减少全身副作用的局部治疗。尽管有这些优势，角质层由于其致密的脂质-蛋白质结构和对酶降解的敏感性，对核酸的递送构成了一个强大的障碍。最近纳米颗粒技术的创新，如阳离子脂质体和聚合物载体，通过增强穿透性、稳定性和靶向特异性，克服了这些挑战。此外，微针和离子渗透应用等技术进一步促进了皮肤层的有效递送。将纳米颗粒与治疗药物（如siRNA和CRISPR-Cas9）结合的先进配方在肿瘤生长抑制、免疫调节和基因校正方面显示出显著的潜力。这些方法提供了有针对性的治疗选择，减少了耐药性，并支持对皮肤状况进行基因改造。虽然免疫原性和系统降解等挑战仍然存在，但人工智能（AI）的新兴集成优化了纳米颗粒的设计和输送系统。人工智能驱动的进步有望改进透皮给药技术，推进皮肤病学应用和癌症治疗中的精准医学。

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引用次数: 0

Editorial overview: Current perspectives in bioelectronic medicine: Mechanisms, technologies, and clinical frontiers 编辑概述：生物电子医学的当前观点：机制、技术和临床前沿

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-06-26 DOI: 10.1016/j.cobme.2025.100610

Tracy Cui, Douglas J. Weber

引用次数: 0

Organoid bioprinting to pattern the matrix microenvironment 类器官生物打印以模拟基质微环境

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-06-05 DOI: 10.1016/j.cobme.2025.100607

Daiyao Zhang , Carla Huerta-López , Sarah C. Heilshorn

The development of organoid cultures has propelled the fields of cell biology, tissue engineering, and regenerative medicine forward. These cultures better mimic in vivo tissue structure and function compared to 2D cell culture; however, organoids are limited in size and do not inherently allow precise control over tissue architecture and cell heterogeneity. Hand-wrought organoid biofabrication approaches enable the production of larger and more complex tissues, but they still lack reproducible control of spatiotemporal tissue patterns. In contrast, bioprinting is a collection of machine-wrought technologies that are emerging as powerful tools in tissue engineering and disease modeling, but have not yet been widely applied to organoids. When combined with advances in biomaterials science, bioprinting offers the possibility to control spatiotemporal cellular and microenvironmental features. The interactions between biomaterial inks, support baths, and embedded cells provide the opportunity to guide the maturation and functionality of engineered tissues. This review describes how recent advances in organoid technology, bioprinting, and biomaterials science can be integrated to achieve spatiotemporal patterning of four aspects of the microenvironment: matrix structure and mechanics, matrix ligands and morphogens, co-culture of multiple cell types, and incorporation of vasculature. These insights underscore the potential for organoid bioprinting to advance the fabrication of in vitro tissue mimics for applications in drug screening, disease modeling, and regenerative medicine.

类器官培养的发展推动了细胞生物学、组织工程和再生医学领域的发展。与二维细胞培养相比，这些培养物能更好地模拟体内组织结构和功能；然而，类器官在大小上是有限的，并且不允许对组织结构和细胞异质性进行精确控制。手工制作的类器官生物制造方法能够生产更大、更复杂的组织，但它们仍然缺乏对时空组织模式的可重复性控制。相比之下，生物打印是一种机器制造技术的集合，它正在成为组织工程和疾病建模的强大工具，但尚未广泛应用于类器官。当与生物材料科学的进步相结合时，生物打印提供了控制时空细胞和微环境特征的可能性。生物材料墨水、支撑液和嵌入细胞之间的相互作用为指导工程组织的成熟和功能提供了机会。本文介绍了如何将类器官技术、生物打印和生物材料科学的最新进展整合起来，以实现微环境的四个方面的时空模式：基质结构和力学、基质配体和形态原、多种细胞类型的共培养以及血管系统的整合。这些发现强调了类器官生物打印技术在药物筛选、疾病建模和再生医学中促进体外组织模拟制造的潜力。

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引用次数: 0

Editorial overview: Scaffold-based and scaffold-free approaches for mechanobiology, in vitro disease modeling and treatment 综述：基于支架和无支架的机械生物学、体外疾病建模和治疗方法

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-06-05 DOI: 10.1016/j.cobme.2025.100609

Angelo Accardo, Enrico D. Lemma

引用次数: 0

The next phase of mammalian synthetic biology: Trends and applications 哺乳动物合成生物学的下一阶段：趋势和应用

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-06-04 DOI: 10.1016/j.cobme.2025.100608

Wilson W. Wong, Ahmad S. Khalil

引用次数: 0

Microfluidic and organ-on-a-chip approaches to model the tumor microenvironment 微流控和器官芯片方法模拟肿瘤微环境

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-06-02 DOI: 10.1016/j.cobme.2025.100606

Valentin Bonnet , Emmanouil Angelidakis , Sébastien Sart , Charles N. Baroud

The tumor microenvironment (TME) is a complex ecosystem that involves cancer cells, immune and stromal cells, in addition to extracellular matrix and secreted factors. The interactions within this complex ecosystem regulate tumor cell phenotypes and direct cancer progression, making their understanding essential for advancing our knowledge of cancer biology and developing innovative treatments. Since standard culture conditions cannot account for the complexity of the TME, organ-on-a-chip (OOC) technologies have been developed to fill this need. Here, we describe the recent advances in OOCs designed to improve in vitro models of the TME by controlling the physical, chemical, geometrical, and biological environment of tumor cells. We begin with studies that leverage OOCs to understand cancer biology, followed by a description of works that test drug effects within the TME. Finally, we discuss future avenues for development that will enhance the interest of OOCs for diverse applications, including clinical testing.

肿瘤微环境（tumor microenvironment， TME）是一个复杂的生态系统，除细胞外基质和分泌因子外，还涉及癌细胞、免疫细胞和基质细胞。在这个复杂的生态系统内的相互作用调节肿瘤细胞表型和直接癌症进展，使他们的理解对推进我们的癌症生物学知识和开发创新治疗至关重要。由于标准培养条件无法解释TME的复杂性，因此开发了器官芯片（OOC）技术来满足这一需求。在这里，我们描述了通过控制肿瘤细胞的物理、化学、几何和生物环境来改善体外TME模型的OOCs的最新进展。我们从利用ooc来了解癌症生物学的研究开始，然后描述在TME内测试药物作用的工作。最后，我们讨论了未来的发展途径，这将提高OOCs在各种应用中的兴趣，包括临床测试。

引用次数: 0

Bioengineering gradients for controlled embryo and organ modeling 控制胚胎和器官建模的生物工程梯度

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-05-31 DOI: 10.1016/j.cobme.2025.100605

Shiyu Sun , Zhuowei Zhou , Aoife Tang , Jianping Fu

Symmetry breaking and tissue patterning are fundamental processes in mammalian development. Understanding these events is essential not only for advancing mammalian developmental biology but also for the ongoing efforts to create in vitro models of mammalian embryogenesis and organogenesis using stem cells. This review highlights recent bioengineering innovations designed to control exogenous and endogenous gradients of soluble biochemical signals and insoluble biophysical cues, effectively guiding cell differentiation and spatial organization in embryo and organ modeling. Specifically, we discuss microfluidics- and micropatterning-based multicellular culture systems, as well as approaches that use porous beads loaded with soluble factors and engineered cells as synthetic signaling centers to replicate dynamic in vivo signaling. We evaluate the effectiveness and limitations of each technique in influencing cell fate decisions, morphogenesis, and patterning, and explore their applications in modeling mammalian development. Finally, we outline emerging approaches that leverage bioengineered tools to construct mammalian embryo and organ models for both basic research and translational applications.

对称破坏和组织图案是哺乳动物发育的基本过程。了解这些事件不仅对推进哺乳动物发育生物学至关重要，而且对正在进行的利用干细胞建立哺乳动物胚胎发生和器官发生的体外模型也至关重要。本文综述了最近的生物工程创新，旨在控制外源性和内源性可溶性生化信号和不可溶性生物物理信号的梯度，有效地指导胚胎和器官建模中的细胞分化和空间组织。具体来说，我们讨论了基于微流体和微模式的多细胞培养系统，以及使用负载可溶性因子的多孔珠和工程细胞作为合成信号中心来复制动态体内信号的方法。我们评估了每种技术在影响细胞命运决定、形态发生和模式方面的有效性和局限性，并探索了它们在哺乳动物发育建模中的应用。最后，我们概述了利用生物工程工具构建哺乳动物胚胎和器官模型的新兴方法，用于基础研究和转化应用。

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引用次数: 0

Recent advances in niosome-based transdermal drug delivery systems 基于niosome的透皮给药系统的最新进展

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-05-24 DOI: 10.1016/j.cobme.2025.100603

Lefkothea Antonara , Efstathia Triantafyllopoulou , Maria Chountoulesi , Natassa Pippa , Nefeli Lagopati , Paraskevas P. Dallas , Dimitrios M. Rekkas , Maria Gazouli

Niosomes are promising drug delivery nanosystems for transdermal administration. They exhibit several advantages for drug delivery and targeting applications, (i.e. biocompatibility, increased physical stability, modified drug release properties, low cost, and easy scale-up). Additionally, they are deemed as favorable candidates caused by their capability to enhance skin permeation, which is the main challenge in transcutaneous delivery. The aim of this review is to summarize from a critical point of view the most recent niosome-based nanoparticulate formulations for transdermal administration and their added value in pharmaceutical technology and engineering. The formulation protocols, the main excipients and Active Pharmaceutical Ingredients (APIs), and the main physicochemical and biological properties and applications of niosome-based transdermal drug delivery systems are discussed and analyzed. Taking into account their scale-up in the pharmaceutical industry, the critical quality attributes (CQAs), along with the most critical design and process parameters, are reviewed in depth, while existing limitations are also considered. Niosomes are candidate drug delivery platforms with added value in transdermal administration.

纳米粒是一种很有前途的经皮给药纳米系统。它们在药物递送和靶向应用方面具有几个优点（即生物相容性，增加的物理稳定性，修饰的药物释放特性，低成本和易于扩大规模）。此外，它们被认为是有利的候选者，因为它们具有增强皮肤渗透的能力，这是经皮给药的主要挑战。这篇综述的目的是从一个关键的角度来总结最新的基于纳米粒的透皮给药配方及其在制药技术和工程中的附加价值。讨论和分析了niosomes基透皮给药系统的配方方案、主要赋形剂和活性药物成分，以及主要的理化生物学特性和应用。考虑到它们在制药工业中的规模扩大，对关键质量属性（cqa）以及最关键的设计和工艺参数进行了深入审查，同时也考虑了现有的限制。Niosomes是候选的药物传递平台，在经皮给药中具有附加价值。

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引用次数: 0

Tuning the matrix: Recent advances in mechanobiology unveiled through polyacrylamide hydrogels 调整基质：聚丙烯酰胺水凝胶揭示了机械生物学的最新进展

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-05-22 DOI: 10.1016/j.cobme.2025.100604

Giuseppe Ciccone , Manuel Salmeron-Sanchez

Over the past 30 years, polyacrylamide (PAAm) hydrogels have become essential tools to mimic the mechanical properties, chemical composition, and dimensionality of the extracellular matrix (ECM) in in vitro mechanobiology studies. This brief review highlights recent developments that have transformed PAAm hydrogels from simple 2D static elastic hydrogels to complex ECM-mimicking systems involving protein micropatterning, mechanical patterning, stretching, DNA tension probes, viscoelasticity, and the microfabrication of 3D systems. We focus on novel mechanobiological questions that have been elucidated using these platforms and give a perspective on the future of PAAm hydrogels for mechanobiology research.

在过去的30年里，在体外力学生物学研究中，聚丙烯酰胺（PAAm）水凝胶已经成为模拟细胞外基质（ECM）的力学特性、化学成分和尺寸的重要工具。本文简要回顾了PAAm水凝胶从简单的二维静态弹性水凝胶到复杂的ecm模拟系统的最新进展，包括蛋白质微图谱、机械图谱、拉伸、DNA张力探针、粘弹性和3D系统的微制造。我们将重点关注利用这些平台阐明的新的机械生物学问题，并对PAAm水凝胶用于机械生物学研究的未来进行展望。

引用次数: 0

Microneedle-assisted nanomedicine: Emerging strategies for transdermal drug delivery 微针辅助纳米医学：经皮给药的新策略

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-05-21 DOI: 10.1016/j.cobme.2025.100602

Atefeh Zarepour , Asieh Soozanipour , Arezoo Khosravi

Transdermal drug delivery provides a non-invasive and patient-friendly alternative to conventional administration routes, such as injections and oral medications. Among the latest innovations, microneedles have emerged as a promising technology, offering painless and minimally invasive drug delivery through the skin. MNs allow for precise and controlled drug release, improving therapeutic outcomes while minimizing side effects. Recent advances have focused on integrating nanomaterials—such as nanoparticles, liposomes, and polymeric carriers—into MN systems to enhance drug penetration, targeting, and release kinetics. This combination can overcome the skin's natural barrier, enabling accurate dosing and improved patient compliance. This review explores the principles and advantages of nanomaterial-based microneedles for transdermal delivery, highlighting their role in improving treatment efficiency and patient outcomes. Additionally, we discuss critical challenges in microneedle development, including fabrication scalability, skin compatibility, and long-term stability. Finally, future directions for clinical translation are examined, underscoring their strong potential in modern therapeutic strategies.

经皮给药为传统给药途径（如注射和口服药物）提供了一种非侵入性和对患者友好的替代方法。在最新的创新中，微针已经成为一种很有前途的技术，可以通过皮肤提供无痛和微创的药物输送。MNs允许精确和控制药物释放，提高治疗效果，同时最大限度地减少副作用。最近的进展主要集中在将纳米材料（如纳米颗粒、脂质体和聚合物载体）整合到MN系统中，以增强药物的渗透、靶向和释放动力学。这种组合可以克服皮肤的天然屏障，使准确的剂量和提高患者的依从性。本文综述了基于纳米材料的微针透皮给药的原理和优势，强调了它们在提高治疗效率和患者预后方面的作用。此外，我们还讨论了微针开发中的关键挑战，包括制造可扩展性，皮肤兼容性和长期稳定性。最后，研究了临床翻译的未来方向，强调了它们在现代治疗策略中的强大潜力。

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