Current Opinion in Biomedical Engineering最新文献

英文中文

Bioengineering gradients for controlled embryo and organ modeling 控制胚胎和器官建模的生物工程梯度

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-05-31 DOI: 10.1016/j.cobme.2025.100605

Shiyu Sun , Zhuowei Zhou , Aoife Tang , Jianping Fu

Symmetry breaking and tissue patterning are fundamental processes in mammalian development. Understanding these events is essential not only for advancing mammalian developmental biology but also for the ongoing efforts to create in vitro models of mammalian embryogenesis and organogenesis using stem cells. This review highlights recent bioengineering innovations designed to control exogenous and endogenous gradients of soluble biochemical signals and insoluble biophysical cues, effectively guiding cell differentiation and spatial organization in embryo and organ modeling. Specifically, we discuss microfluidics- and micropatterning-based multicellular culture systems, as well as approaches that use porous beads loaded with soluble factors and engineered cells as synthetic signaling centers to replicate dynamic in vivo signaling. We evaluate the effectiveness and limitations of each technique in influencing cell fate decisions, morphogenesis, and patterning, and explore their applications in modeling mammalian development. Finally, we outline emerging approaches that leverage bioengineered tools to construct mammalian embryo and organ models for both basic research and translational applications.

对称破坏和组织图案是哺乳动物发育的基本过程。了解这些事件不仅对推进哺乳动物发育生物学至关重要，而且对正在进行的利用干细胞建立哺乳动物胚胎发生和器官发生的体外模型也至关重要。本文综述了最近的生物工程创新，旨在控制外源性和内源性可溶性生化信号和不可溶性生物物理信号的梯度，有效地指导胚胎和器官建模中的细胞分化和空间组织。具体来说，我们讨论了基于微流体和微模式的多细胞培养系统，以及使用负载可溶性因子的多孔珠和工程细胞作为合成信号中心来复制动态体内信号的方法。我们评估了每种技术在影响细胞命运决定、形态发生和模式方面的有效性和局限性，并探索了它们在哺乳动物发育建模中的应用。最后，我们概述了利用生物工程工具构建哺乳动物胚胎和器官模型的新兴方法，用于基础研究和转化应用。

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引用次数: 0

The next phase of mammalian synthetic biology: Trends and applications 哺乳动物合成生物学的下一阶段：趋势和应用

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-06-04 DOI: 10.1016/j.cobme.2025.100608

Wilson W. Wong, Ahmad S. Khalil

引用次数: 0

Recent advances in hydrogel-based platforms for periodontal tissue regeneration 基于水凝胶的牙周组织再生平台研究进展

IF 4.2 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-07-16 DOI: 10.1016/j.cobme.2025.100615

Reihaneh Khademi, Mahshid Kharaziha

Periodontitis is a severe and progressive inflammatory disease triggered by microbial infection, destroying essential tooth-supporting structures, including the alveolar bone, gingiva, periodontal ligament, and cementum. While traditional therapies like scaling and root planning can effectively manage disease progression, they often fail to restore the natural architecture and functionality of periodontal tissues due to the limited regenerative capacity of these structures. Periodontal tissue engineering has emerged as a promising solution to this challenge. This technology is based on multifunctional biomaterials, especially hydrogels, for restoring damaged alveolar bone, periodontal ligament, and root cementum. This review aims to provide a comprehensive overview of the properties required for hydrogels to facilitate periodontal tissue regeneration. Moreover, it discusses the use of hydrogels as delivery systems for cells, drugs, and growth factors, as well as their role in photothermal therapy and periodontal tissue regeneration. Finally, the review addresses the current challenges associated with the use of hydrogels and outlines the potential future directions for integrating hydrogels into periodontitis treatment and diagnosis.

牙周炎是一种严重的进行性炎症性疾病，由微生物感染引起，破坏牙齿的基本支撑结构，包括牙槽骨、牙龈、牙周韧带和牙骨质。虽然像刮治和牙根规划这样的传统疗法可以有效地控制疾病的进展，但由于牙周组织的再生能力有限，它们往往无法恢复牙周组织的自然结构和功能。牙周组织工程已成为解决这一挑战的一个有希望的解决方案。该技术基于多功能生物材料，特别是水凝胶，用于修复受损的牙槽骨、牙周韧带和牙根骨质。本文综述了促进牙周组织再生所需的水凝胶的性能。此外，它还讨论了水凝胶作为细胞、药物和生长因子的递送系统的使用，以及它们在光热治疗和牙周组织再生中的作用。最后，回顾了目前与水凝胶使用相关的挑战，并概述了将水凝胶整合到牙周炎治疗和诊断中的潜在未来方向。

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引用次数: 0

Organoids and derived models to study the microenvironments of bacterial infections 研究细菌感染微环境的类器官和衍生模型

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-05-14 DOI: 10.1016/j.cobme.2025.100595

Katrina Lyon, Kai Yee Eng, Francesco Boccellato, Antonella D'Amore

The microenvironment of an infection is the biological space surrounding the interaction between the pathogen and the host. Focusing on epithelial barriers, the apical microenvironment corresponds to the lumen of the organ, where the pathogen must survive amidst body fluids, microbiota, and cellular secretions. On the opposite side, the basal microenvironment includes stromal cells, endothelial cells of blood vessels, and immune cells recruited to combat infection. The first distinguishing element between the apical and basal domains is the epithelium itself, which consists of polarized cells that secrete different molecules to their apical and basal domains. Organoids and other stem cell-derived culture systems have emerged as valuable models for studying epithelial barriers and their capacities for pathogen recognition, inflammatory signalling, and differentiation. By mimicking multiple aspects of epithelial biology in vitro, organoids provide an opportunity to investigate infections from the initial attack to the subsequent defences. This review explores how organoids, stem cell-derived planar cultures, and micro-physiological systems are transforming our understanding of infection microenvironments.

感染的微环境是围绕病原体和宿主之间相互作用的生物空间。关注上皮屏障，根尖微环境对应于器官的管腔，病原体必须在体液、微生物群和细胞分泌物中生存。另一方面，基底微环境包括基质细胞、血管内皮细胞和对抗感染的免疫细胞。顶域和基域之间的第一个区别是上皮本身，上皮由极化细胞组成，它们向顶域和基域分泌不同的分子。类器官和其他干细胞衍生的培养系统已经成为研究上皮屏障及其病原体识别、炎症信号和分化能力的有价值的模型。通过在体外模拟上皮生物学的多个方面，类器官提供了一个机会来研究从最初的攻击到随后的防御的感染。这篇综述探讨了类器官、干细胞衍生的平面培养和微生理系统如何改变我们对感染微环境的理解。

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引用次数: 0

Microneedle-assisted nanomedicine: Emerging strategies for transdermal drug delivery 微针辅助纳米医学：经皮给药的新策略

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-05-21 DOI: 10.1016/j.cobme.2025.100602

Atefeh Zarepour , Asieh Soozanipour , Arezoo Khosravi

Transdermal drug delivery provides a non-invasive and patient-friendly alternative to conventional administration routes, such as injections and oral medications. Among the latest innovations, microneedles have emerged as a promising technology, offering painless and minimally invasive drug delivery through the skin. MNs allow for precise and controlled drug release, improving therapeutic outcomes while minimizing side effects. Recent advances have focused on integrating nanomaterials—such as nanoparticles, liposomes, and polymeric carriers—into MN systems to enhance drug penetration, targeting, and release kinetics. This combination can overcome the skin's natural barrier, enabling accurate dosing and improved patient compliance. This review explores the principles and advantages of nanomaterial-based microneedles for transdermal delivery, highlighting their role in improving treatment efficiency and patient outcomes. Additionally, we discuss critical challenges in microneedle development, including fabrication scalability, skin compatibility, and long-term stability. Finally, future directions for clinical translation are examined, underscoring their strong potential in modern therapeutic strategies.

经皮给药为传统给药途径（如注射和口服药物）提供了一种非侵入性和对患者友好的替代方法。在最新的创新中，微针已经成为一种很有前途的技术，可以通过皮肤提供无痛和微创的药物输送。MNs允许精确和控制药物释放，提高治疗效果，同时最大限度地减少副作用。最近的进展主要集中在将纳米材料（如纳米颗粒、脂质体和聚合物载体）整合到MN系统中，以增强药物的渗透、靶向和释放动力学。这种组合可以克服皮肤的天然屏障，使准确的剂量和提高患者的依从性。本文综述了基于纳米材料的微针透皮给药的原理和优势，强调了它们在提高治疗效率和患者预后方面的作用。此外，我们还讨论了微针开发中的关键挑战，包括制造可扩展性，皮肤兼容性和长期稳定性。最后，研究了临床翻译的未来方向，强调了它们在现代治疗策略中的强大潜力。

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引用次数: 0

Spatiotemporally-patterned biomaterials for organoid culture 用于类器官培养的时空模式生物材料

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-05-08 DOI: 10.1016/j.cobme.2025.100594

Luis F. Arrieta-Viana , Andrés J. García

Spatiotemporally-patterned biomaterials have emerged as powerful tools for enhancing organoid development and functionality by recreating the dynamic complexity of native tissues. Recent innovations in photopatterning, bioprinting, and stimuli-responsive materials have expanded our ability to control the cellular microenvironment with remarkable precision. These advances have significantly improved our ability to control organoid development, leading to better structural organization and functionality. However, transitioning from proof-of-concept studies to standardized, scalable platforms remains challenging. Breakthrough technologies developed in recent years have transformed organoid applications and accelerated their translation. We suggest that the integration of multiple control systems, especially through microfluidics and “smart” materials, offers the most promising path toward realizing the full potential of organoid technologies.

时空模式生物材料已经成为通过重建原生组织的动态复杂性来增强类器官发育和功能的有力工具。最近在光图案、生物打印和刺激响应材料方面的创新扩大了我们以惊人的精度控制细胞微环境的能力。这些进步大大提高了我们控制类器官发育的能力，导致更好的结构组织和功能。然而，从概念验证研究到标准化、可扩展平台的过渡仍然具有挑战性。近年来发展的突破性技术已经改变了类器官的应用并加速了它们的转化。我们认为，集成多个控制系统，特别是通过微流体和“智能”材料，为实现类器官技术的全部潜力提供了最有希望的途径。

引用次数: 0

Gut-on-chip and liver-on-chip platforms for pathophysiological modeling 用于病理生理建模的肠道芯片和肝脏芯片平台

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-05-17 DOI: 10.1016/j.cobme.2025.100601

Chiara Coricciati , Eleonora Mello , Elisa De Luca , Giuseppe Gigli , Alberto Rainer , Pamela Mozetic

Organs-on-chips (OoCs) are micro-engineered systems recapitulating the microenvironment and functions of native organs, thus representing a platform for studying complex biological processes in vitro. Advances in OoC technology have transformed the landscape of disease modeling, opening new avenues for research and therapeutic development. Gut- and liver-on-chip models are particularly relevant, given the involvement of these two organs in several physiological processes. Indeed, the intricate interactions between the gastrointestinal and hepatic systems, named gut-liver axis, play a key role in metabolic processes and in the pathogenesis of several conditions such as non-alcoholic fatty liver disease and inflammatory bowel disease. This review summarizes the advancements in the field of gut- and liver-on-chip models over the past five years, focusing on their application in disease modeling. By highlighting recent developments and open challenges, we aim to underscore the potential of these systems in enhancing our understanding of disease mechanisms and improving therapeutic strategies.

芯片上器官（器官芯片）是一种再现天然器官微环境和功能的微工程系统，因此代表了研究体外复杂生物过程的平台。OoC技术的进步改变了疾病建模的格局，为研究和治疗开发开辟了新的途径。肠道和肝脏芯片模型尤其相关，因为这两个器官参与了几个生理过程。事实上，胃肠道和肝脏系统之间复杂的相互作用，被称为肠-肝轴，在代谢过程和非酒精性脂肪性肝病和炎症性肠病等几种疾病的发病机制中起着关键作用。本文综述了近五年来肠道和肝脏芯片模型的研究进展，重点介绍了它们在疾病建模中的应用。通过强调最近的发展和开放的挑战，我们的目标是强调这些系统在增强我们对疾病机制的理解和改进治疗策略方面的潜力。

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引用次数: 0

Imaging the microscale mechanical properties of cancer using optical coherence elastography 利用光学相干弹性成像技术对癌症的微观力学特性进行成像

IF 4.2 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-07-11 DOI: 10.1016/j.cobme.2025.100614

Rowan W. Sanderson , Brendan F. Kennedy

Optical coherence elastography (OCE) is emerging as an important technique in characterising and mapping the mechanical properties of cancer on the microscale. This review presents the latest advances in the development of OCE for oncology, highlighting cancer mechanobiology, drug-delivery monitoring and clinical diagnostics as the three most promising areas. Key technical innovations are described including the development of novel loading methods to enable the imaging of single cells, as well as the design of imaging probes that enable OCE's application to in vivo imaging. We also provide our perspective on how these developments may shape future translation and adoption of OCE in oncology.

光学相干弹性成像（OCE）是一种在微观尺度上表征和绘制癌症力学特性的重要技术。本文综述了肿瘤OCE的最新进展，重点介绍了肿瘤机械生物学、药物传递监测和临床诊断三个最有前景的领域。关键的技术创新包括开发新的加载方法，使单细胞成像，以及成像探针的设计，使OCE应用于体内成像。我们还提供了我们对这些发展如何影响OCE在肿瘤学中的未来翻译和采用的观点。

引用次数: 0

Recent advances in niosome-based transdermal drug delivery systems 基于niosome的透皮给药系统的最新进展

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-05-24 DOI: 10.1016/j.cobme.2025.100603

Lefkothea Antonara , Efstathia Triantafyllopoulou , Maria Chountoulesi , Natassa Pippa , Nefeli Lagopati , Paraskevas P. Dallas , Dimitrios M. Rekkas , Maria Gazouli

Niosomes are promising drug delivery nanosystems for transdermal administration. They exhibit several advantages for drug delivery and targeting applications, (i.e. biocompatibility, increased physical stability, modified drug release properties, low cost, and easy scale-up). Additionally, they are deemed as favorable candidates caused by their capability to enhance skin permeation, which is the main challenge in transcutaneous delivery. The aim of this review is to summarize from a critical point of view the most recent niosome-based nanoparticulate formulations for transdermal administration and their added value in pharmaceutical technology and engineering. The formulation protocols, the main excipients and Active Pharmaceutical Ingredients (APIs), and the main physicochemical and biological properties and applications of niosome-based transdermal drug delivery systems are discussed and analyzed. Taking into account their scale-up in the pharmaceutical industry, the critical quality attributes (CQAs), along with the most critical design and process parameters, are reviewed in depth, while existing limitations are also considered. Niosomes are candidate drug delivery platforms with added value in transdermal administration.

纳米粒是一种很有前途的经皮给药纳米系统。它们在药物递送和靶向应用方面具有几个优点（即生物相容性，增加的物理稳定性，修饰的药物释放特性，低成本和易于扩大规模）。此外，它们被认为是有利的候选者，因为它们具有增强皮肤渗透的能力，这是经皮给药的主要挑战。这篇综述的目的是从一个关键的角度来总结最新的基于纳米粒的透皮给药配方及其在制药技术和工程中的附加价值。讨论和分析了niosomes基透皮给药系统的配方方案、主要赋形剂和活性药物成分，以及主要的理化生物学特性和应用。考虑到它们在制药工业中的规模扩大，对关键质量属性（cqa）以及最关键的设计和工艺参数进行了深入审查，同时也考虑了现有的限制。Niosomes是候选的药物传递平台，在经皮给药中具有附加价值。

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Hyaluronic acid-based models of the brain microenvironment: Challenges and advances 基于透明质酸的大脑微环境模型：挑战和进展

IF 4.2 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering

Pub Date : 2025-09-01 Epub Date: 2025-07-02 DOI: 10.1016/j.cobme.2025.100613

Anna Weldy , Sanjay Kumar

While hyaluronic acid (HA) extracellular matrix (ECM) models continue to provide valuable insights into brain physiology and disease, much room for improvement remains in terms of capturing the cellular and structural complexity of the brain microenvironment. Here we review next-generation HA models that are aimed at better capturing brain microenvironmental complexity. We discuss functionalization and crosslinking strategies designed to improve HA stability and biocompatibility. We also cover efforts to incorporate ECM proteins and stromal elements into HA hydrogels, including astrocytes, endothelial cells, and macrophages. We conclude with a brief discussion of nascent advancements and applications of these models, ranging from the reconstruction of multicellular stromal structures to the development of high-throughput screening platforms. This new suite of matrix technologies and the resulting applications should contribute greatly to mechanistic and therapeutic discovery in brain physiology and disease.

虽然透明质酸（HA）细胞外基质（ECM）模型继续为大脑生理学和疾病提供有价值的见解，但在捕捉大脑微环境的细胞和结构复杂性方面仍有很大的改进空间。在这里，我们回顾旨在更好地捕捉大脑微环境复杂性的下一代HA模型。我们讨论功能化和交联策略，旨在提高透明质酸的稳定性和生物相容性。我们还介绍了将ECM蛋白和基质元素纳入透明质酸水凝胶的努力，包括星形胶质细胞、内皮细胞和巨噬细胞。最后，我们简要讨论了这些模型的新进展和应用，从多细胞基质结构的重建到高通量筛选平台的发展。这套新的基质技术和由此产生的应用将极大地促进脑生理学和疾病的机制和治疗发现。

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