首页 > 最新文献

CJC Open最新文献

英文 中文
Approach to Right-Sided Chamber Dilatation in Cardiac Shunts: Part 1 of a 2-Part Series 心脏分流术中右侧心腔扩张的方法:两部分系列之第一部分
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.06.005
{"title":"Approach to Right-Sided Chamber Dilatation in Cardiac Shunts: Part 1 of a 2-Part Series","authors":"","doi":"10.1016/j.cjco.2024.06.005","DOIUrl":"10.1016/j.cjco.2024.06.005","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24002555/pdfft?md5=2f6278c7daf59e0c9cf7eff9eaccc443&pid=1-s2.0-S2589790X24002555-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Noninvasive Index Combining Echocardiography and Computed Tomography for Screening for Pulmonary Hypertension in Patients With Systemic Sclerosis 结合超声心动图和计算机断层扫描筛查系统性硬化症肺动脉高压的新型无创指标
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.05.005

Background

In patients with systemic sclerosis (SSc), early detection of pulmonary hypertension (PH) improves survival. This study aimed to investigate whether a combination index (cPAT) of the tricuspid regurgitation jet peak gradient and the ratio of pulmonary artery (PA) diameter to aortic diameter measured by computed tomography (CT; PA ratio) can estimate the mean PA pressure (mPAP) and detect PH more accurately than conventional parameters in SSc patients.

Methods

A total of 36 SSc patients who underwent PH screening were retrospectively analyzed. All patients were screened for PH between 2013 and 2017 by echocardiography, CT, and right heart catheterization. Patients with mPAP > 20 mm Hg by right heart catheterization were diagnosed as having PH. Additionally, patients with an mPAP > 20 mm Hg, pulmonary vascular resistance > 2 Wood units, and PA wedge pressure ≤ 15 mm Hg, for whom other causes were ruled out, including group 2-5, were defined as having pulmonary atrial hypertension.

Results

Of 36 patients, 29 patients were female (81%), and the average duration of SSc was 7.5 years. The mPAP was significantly correlated with the tricuspid regurgitation jet peak gradient (r = 0.734), the PA ratio (r = 0.584), and the cPAT (r = 0.848). In receiver operating characteristic analysis to identify PH, the cPAT showed the highest area under the curve, 0.906, among the 3 parameters. Additionally, in receiver operating characteristic analysis to identify pulmonary atrial hypertension, the cPAT also showed the highest area under the curve, 0.851, among the 3 parameters.

Conclusions

The cPAT is a new index combining echocardiogram and CT results that provides the most accurate noninvasive assessment of mPAP in SSc patients. The cPAT can also help detect PH early in SSc patients, thereby allowing for earlier treatment.

背景在系统性硬化症(SSc)患者中,早期发现肺动脉高压(PH)可提高生存率。本研究旨在探讨三尖瓣反流喷射峰梯度和计算机断层扫描(CT;PA ratio)测量的肺动脉(PA)直径与主动脉直径的比值的组合指数(cPAT)是否能比传统参数更准确地估算出SSc患者的平均肺动脉压力(mPAP)并检测出PH。所有患者均在2013年至2017年期间通过超声心动图、CT和右心导管检查进行了PH筛查。通过右心导管检查发现 mPAP > 20 mm Hg 的患者被诊断为 PH。此外,mPAP > 20 mm Hg、肺血管阻力 > 2 Wood单位、PA楔压≤15 mm Hg且排除其他原因(包括第2-5组)的患者被定义为肺动脉高压。mPAP 与三尖瓣反流喷射峰梯度(r = 0.734)、PA 比值(r = 0.584)和 cPAT(r = 0.848)明显相关。在识别 PH 的接收器操作特征分析中,cPAT 在 3 个参数中显示出最高的曲线下面积(0.906)。结论 cPAT 是一种结合超声心动图和 CT 结果的新指标,可对 SSc 患者的 mPAP 进行最准确的无创评估。cPAT 还有助于早期发现 SSc 患者的 PH,从而及早进行治疗。
{"title":"Novel Noninvasive Index Combining Echocardiography and Computed Tomography for Screening for Pulmonary Hypertension in Patients With Systemic Sclerosis","authors":"","doi":"10.1016/j.cjco.2024.05.005","DOIUrl":"10.1016/j.cjco.2024.05.005","url":null,"abstract":"<div><h3>Background</h3><p>In patients with systemic sclerosis (SSc), early detection of pulmonary hypertension (PH) improves survival. This study aimed to investigate whether a combination index (cPAT) of the tricuspid regurgitation jet peak gradient and the ratio of pulmonary artery (PA) diameter to aortic diameter measured by computed tomography (CT; PA ratio) can estimate the mean PA pressure (mPAP) and detect PH more accurately than conventional parameters in SSc patients.</p></div><div><h3>Methods</h3><p>A total of 36 SSc patients who underwent PH screening were retrospectively analyzed. All patients were screened for PH between 2013 and 2017 by echocardiography, CT, and right heart catheterization. Patients with mPAP &gt; 20 mm Hg by right heart catheterization were diagnosed as having PH. Additionally, patients with an mPAP &gt; 20 mm Hg, pulmonary vascular resistance &gt; 2 Wood units, and PA wedge pressure ≤ 15 mm Hg, for whom other causes were ruled out, including group 2-5, were defined as having pulmonary atrial hypertension.</p></div><div><h3>Results</h3><p>Of 36 patients, 29 patients were female (81%), and the average duration of SSc was 7.5 years. The mPAP was significantly correlated with the tricuspid regurgitation jet peak gradient (<em>r</em> = 0.734), the PA ratio (<em>r</em> = 0.584), and the cPAT (<em>r</em> = 0.848). In receiver operating characteristic analysis to identify PH, the cPAT showed the highest area under the curve, 0.906, among the 3 parameters. Additionally, in receiver operating characteristic analysis to identify pulmonary atrial hypertension, the cPAT also showed the highest area under the curve, 0.851, among the 3 parameters.</p></div><div><h3>Conclusions</h3><p>The cPAT is a new index combining echocardiogram and CT results that provides the most accurate noninvasive assessment of mPAP in SSc patients. The cPAT can also help detect PH early in SSc patients, thereby allowing for earlier treatment.</p></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24002154/pdfft?md5=e2f47b5127e47dfc392362d60b354c76&pid=1-s2.0-S2589790X24002154-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141053476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Disparities in the Use and Outcomes of Septal Reduction Therapies for Obstructive Hypertrophic Cardiomyopathy 阻塞性肥厚型心肌病室间隔缩窄疗法的使用和疗效方面的性别差异
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.05.013

Background

Data are limited that examine potential sex-based disparities in the utilization and complications of septal reduction therapy (SRT) in patients with obstructive hypertrophic cardiomyopathy. Our aim was to assess the use and in-hospital outcomes of SRT, according to sex. We performed a retrospective cohort study using the 2017-2019 National Inpatient Sample database. Adult patients with obstructive hypertrophic cardiomyopathy were identified.

Methods

We assessed the use of SRT (surgical septal myectomy and alcohol septal ablation), according to sex. In those who underwent SRT, rates of in-hospital mortality, pacemaker implantation, implantable cardioverter defibrillator (ICD) implantation, ischemic stroke, major bleeding, and pericardial complication were assessed. All outcomes were compared between groups using inverse probability of treatment weighting (IPTW), adjusting for demographics, comorbidity burden, and hospital characteristics.

Results

In total, 72,680 weighted hospitalizations (median age: 67 years [range: 57-77]; 61% female patients) were included, and only 5.9% of patients underwent SRT. After IPTW adjustment, female patients were more likely to undergo SRT (adjusted risk ratio [aRR] 1.18, 95% confidence interval [95% CI] 1.03-1.36) and alcohol septal ablation (aRR 1.38, 95% CI 1.04-1.83). Likewise, female patients received pacemaker implantation more often (aRR 1.96, 95% CI 1.10-3.50) and ICD implantation (aRR 0.58, 95% CI 0.34-0.99) less frequently, compared with male patients. No differences were present in rates of surgical septal myectomy, in-hospital mortality, ischemic stroke, major bleeding, and pericardial complication between groups.

Conclusions

Our results suggest that female patients were slightly more likely to undergo SRT, especially alcohol septal ablation. In-hospital mortality and postprocedural complications were similar between the sexes, but women received more pacemaker implantation and less ICD implantation.

背景研究阻塞性肥厚型心肌病患者在使用室间隔减容疗法(SRT)和并发症方面可能存在的性别差异的数据非常有限。我们的目的是根据性别评估 SRT 的使用情况和院内预后。我们利用 2017-2019 年全国住院患者样本数据库进行了一项回顾性队列研究。方法我们根据性别评估了SRT(外科室间隔肌切除术和酒精室间隔消融术)的使用情况。我们评估了接受 SRT 的患者的院内死亡率、起搏器植入率、植入式心律转复除颤器(ICD)植入率、缺血性中风率、大出血率和心包并发症率。结果共纳入了 72,680 例加权住院病例(中位年龄:67 岁 [范围:57-77];61% 为女性患者),只有 5.9% 的患者接受了 SRT 治疗。经过 IPTW 调整后,女性患者更有可能接受 SRT(调整风险比 [aRR] 1.18,95% 置信区间 [95% CI] 1.03-1.36)和酒精隔消融术(aRR 1.38,95% CI 1.04-1.83)。同样,与男性患者相比,女性患者接受起搏器植入术的频率更高(aRR 1.96,95% CI 1.10-3.50),接受 ICD 植入术的频率更低(aRR 0.58,95% CI 0.34-0.99)。结论我们的研究结果表明,女性患者接受 SRT 的几率略高,尤其是酒精室间隔消融术。男女患者的院内死亡率和术后并发症相似,但女性接受起搏器植入术的较多,接受 ICD 植入术的较少。
{"title":"Sex Disparities in the Use and Outcomes of Septal Reduction Therapies for Obstructive Hypertrophic Cardiomyopathy","authors":"","doi":"10.1016/j.cjco.2024.05.013","DOIUrl":"10.1016/j.cjco.2024.05.013","url":null,"abstract":"<div><h3>Background</h3><p>Data are limited that examine potential sex-based disparities in the utilization and complications of septal reduction therapy (SRT) in patients with obstructive hypertrophic cardiomyopathy. Our aim was to assess the use and in-hospital outcomes of SRT, according to sex. We performed a retrospective cohort study using the 2017-2019 National Inpatient Sample database. Adult patients with obstructive hypertrophic cardiomyopathy were identified.</p></div><div><h3>Methods</h3><p>We assessed the use of SRT (surgical septal myectomy and alcohol septal ablation), according to sex. In those who underwent SRT, rates of in-hospital mortality, pacemaker implantation, implantable cardioverter defibrillator (ICD) implantation, ischemic stroke, major bleeding, and pericardial complication were assessed. All outcomes were compared between groups using inverse probability of treatment weighting (IPTW), adjusting for demographics, comorbidity burden, and hospital characteristics.</p></div><div><h3>Results</h3><p>In total, 72,680 weighted hospitalizations (median age: 67 years [range: 57-77]; 61% female patients) were included, and only 5.9% of patients underwent SRT. After IPTW adjustment, female patients were more likely to undergo SRT (adjusted risk ratio [aRR] 1.18, 95% confidence interval [95% CI] 1.03-1.36) and alcohol septal ablation (aRR 1.38, 95% CI 1.04-1.83). Likewise, female patients received pacemaker implantation more often (aRR 1.96, 95% CI 1.10-3.50) and ICD implantation (aRR 0.58, 95% CI 0.34-0.99) less frequently, compared with male patients. No differences were present in rates of surgical septal myectomy, in-hospital mortality, ischemic stroke, major bleeding, and pericardial complication between groups.</p></div><div><h3>Conclusions</h3><p>Our results suggest that female patients were slightly more likely to undergo SRT, especially alcohol septal ablation. In-hospital mortality and postprocedural complications were similar between the sexes, but women received more pacemaker implantation and less ICD implantation.</p></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24002257/pdfft?md5=d0b9ef5ef21e0f2c8ff7f2e35d9cbdf7&pid=1-s2.0-S2589790X24002257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total Arch vs Hemiarch Repair in Acute Type A Aortic Dissection: Systematic Review and Meta-Analysis of Comparative Studies 急性 A 型主动脉夹层中的全弓与半弓修复术:比较研究的系统回顾和元分析
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.04.012

Background

We aimed to compare the short- and long-term outcomes of total arch replacement (TAR) vs hemiarch replacement (HAR) in the management of acute type A aortic dissection.

Methods

We searched the literature for studies directly comparing TAR to HAR in acute type A aortic dissection. Hazard ratios (HRs) were extracted from digitized Kaplan-Meier curves.

Results

A total of 6526 patients were identified, of which 2060 (32%) had received a TAR. A total of 37% of patients were female, and the mean age (standard deviation) of the cohort was 59.8 ± 11.8 years. TAR patients had a higher prevalence of preoperative malperfusion (34% vs 26%). The TAR group had higher odds of 30-day mortality (4404 patients; odds ratio [OR] 1.79, 95% confidence interval [CI] 1.29-2.49), renal failure requiring dialysis (3475 patients; OR 1.34, 95% CI 1.02-1.76), and a trend toward higher rates of stroke (3292 patients; OR 1.49, 95% CI 0.93-2.39). No significant differences were observed in prevalence of permanent spinal cord injury, visceral ischemia, or reoperation for bleeding. The TAR group had a non–statistically significant increase in long-term mortality (4408 patients; HR 1.25, 95% CI 0.99-1.57), but showed a trend toward improved freedom from long-term aortic reoperation (1359 patients; HR 0.53; 95% CI 0.18-1.59). In a subgroup analysis, the hazard ratio of long-term mortality favoured TAR in only the subgroup of studies in which the difference in malperfusion was > 10% between groups.

Conclusions

TAR could be associated with improved freedom from long-term aortic reoperation but with potentially increased perioperative risks. We recommend a tailored surgical approach.

背景我们旨在比较全弓置换术(TAR)与半弓置换术(HAR)在治疗急性A型主动脉夹层中的短期和长期疗效。结果共发现 6526 例患者,其中 2060 例(32%)接受了 TAR。37%的患者为女性,平均年龄(标准差)为 59.8 ± 11.8 岁。TAR患者术前灌注不良的发生率更高(34% 对 26%)。TAR组患者的30天死亡率(4404例患者;比值比[OR]1.79,95%置信区间[CI]1.29-2.49)、需要透析的肾衰竭(3475例患者;比值比1.34,95%置信区间[CI]1.02-1.76)和中风发生率呈上升趋势(3292例患者;比值比1.49,95%置信区间[CI]0.93-2.39)。在永久性脊髓损伤、内脏缺血或因出血再次手术的发生率方面没有观察到明显差异。TAR 组的长期死亡率(4408 例患者;HR 1.25,95% CI 0.99-1.57)增加无统计学意义,但主动脉长期再手术率有改善趋势(1359 例患者;HR 0.53;95% CI 0.18-1.59)。在亚组分析中,只有在研究组间灌注不良率差异为 10%的亚组中,长期死亡率的危险比更倾向于 TAR。我们建议采用量身定制的手术方法。
{"title":"Total Arch vs Hemiarch Repair in Acute Type A Aortic Dissection: Systematic Review and Meta-Analysis of Comparative Studies","authors":"","doi":"10.1016/j.cjco.2024.04.012","DOIUrl":"10.1016/j.cjco.2024.04.012","url":null,"abstract":"<div><h3>Background</h3><p>We aimed to compare the short- and long-term outcomes of total arch replacement (TAR) vs hemiarch replacement (HAR) in the management of acute type A aortic dissection.</p></div><div><h3>Methods</h3><p>We searched the literature for studies directly comparing TAR to HAR in acute type A aortic dissection. Hazard ratios (HRs) were extracted from digitized Kaplan-Meier curves.</p></div><div><h3>Results</h3><p>A total of 6526 patients were identified, of which 2060 (32%) had received a TAR. A total of 37% of patients were female, and the mean age (standard deviation) of the cohort was 59.8 ± 11.8 years. TAR patients had a higher prevalence of preoperative malperfusion (34% vs 26%). The TAR group had higher odds of 30-day mortality (4404 patients; odds ratio [OR] 1.79, 95% confidence interval [CI] 1.29-2.49), renal failure requiring dialysis (3475 patients; OR 1.34, 95% CI 1.02-1.76), and a trend toward higher rates of stroke (3292 patients; OR 1.49, 95% CI 0.93-2.39). No significant differences were observed in prevalence of permanent spinal cord injury, visceral ischemia, or reoperation for bleeding. The TAR group had a non–statistically significant increase in long-term mortality (4408 patients; HR 1.25, 95% CI 0.99-1.57), but showed a trend toward improved freedom from long-term aortic reoperation (1359 patients; HR 0.53; 95% CI 0.18-1.59). In a subgroup analysis, the hazard ratio of long-term mortality favoured TAR in only the subgroup of studies in which the difference in malperfusion was &gt; 10% between groups.</p></div><div><h3>Conclusions</h3><p>TAR could be associated with improved freedom from long-term aortic reoperation but with potentially increased perioperative risks. We recommend a tailored surgical approach.</p></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24002208/pdfft?md5=c73272a6f0a2fbc6e7fe18bf80857f1c&pid=1-s2.0-S2589790X24002208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approach to Left-Sided Chamber Dilatation in Cardiac Shunts: Part 2 of a 2-Part Series 心脏分流术中左心房扩张的方法:两部分系列之二
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.06.007
{"title":"Approach to Left-Sided Chamber Dilatation in Cardiac Shunts: Part 2 of a 2-Part Series","authors":"","doi":"10.1016/j.cjco.2024.06.007","DOIUrl":"10.1016/j.cjco.2024.06.007","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24002579/pdfft?md5=6868c8d01552851d952869df50f41f10&pid=1-s2.0-S2589790X24002579-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing Left Bundle Branch Area vs Right-Ventricular Septal Pacing in High-Degree Conduction Disease After Transcatheter Aortic Valve Replacement: Randomized Trial Study Protocol 左束支区与右室间隔起搏在 TAVR 术后高度传导疾病中的比较:随机试验研究方案 左束 BRAVE:研究方案。
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.05.006

Left bundle branch area pacing (LBBAP) is a novel method of conduction-system pacing in the muscular interventricular septum. Although LBBAP has been shown to produce physiologic electrical and mechanical intraventricular synchrony, superiority of LBBAP, compared to right ventricular septal pacing (RVSP) at preserving normal left-ventricular (LV) systolic function after transcatheter aortic valve replacement (TAVR) has not been demonstrated. Left Bundle BRAVE is an investigator-initiated, multicentre, prospective, double-blinded, randomized, crossover study investigating the superiority of LBBAP, compared to RVSP, with respect to preservation of systolic function in patients with high-degree conduction disease after TAVR. Adults with severe aortic stenosis and normal systolic function who sustain high-grade atrioventricular block within 4 weeks of TAVR are eligible. All subjects receive a biventricular pacemaker generator with RVSP, and LBBAP leads. Participants are randomly assigned to 9 months of each pacing mode, in series. The primary endpoint is change in global longitudinal strain, tested in series with change in LV ejection fraction, comparing RVSP to LBBAP. Secondary endpoints include the following: echocardiographic markers of interventricular synchrony and right ventricular performance; heart failure functional status and symptom classification; 6-minute walk test results; pacemaker and lead performance; and brain natriuretic peptide concentration. The Left Bundle BRAVE study is designed to identify an upstream and clinically relevant marker of superiority in LBBAP, compared to RVSP, at preventing deterioration of LV function in patients with a high ventricular pacing burden after TAVR.

ClinicalTrials.gov identifier

NCT05541679

左束支区起搏(LBBAP)是一种在肌性室间隔进行传导系统起搏的新方法。虽然左束支区起搏已被证明能产生生理上的心室内电气和机械同步,但与右室间隔起搏(RVSP)相比,左束支区起搏在经导管主动脉瓣置换术(TAVR)后保留正常左室收缩功能方面的优势尚未得到证实。左束 BRAVE 是一项由研究者发起的多中心、前瞻性、双盲、随机、交叉研究,旨在调查 LBBAP 与 RVSP 相比,在经导管主动脉瓣置换术后高度传导疾病患者的收缩功能保护方面的优越性。患有严重主动脉瓣狭窄且收缩功能正常的成人,如果在 TAVR 术后 4 周内出现高度房室传导阻滞,则符合条件。所有受试者均接受带有 RVSP 和 LBBAP 导联的双心室起搏器。受试者被随机分配到每种起搏模式下进行为期 9 个月的系列治疗。主要终点是整体纵向应变的变化,与左心室射血分数的变化一起进行系列测试,比较 RVSP 和 LBBAP。次要终点包括:心室间同步性和右心室性能的超声心动图标记;心衰功能状态和症状分类;6 分钟步行测试结果;起搏器和导联性能;脑钠肽浓度。左束BRAVE研究旨在确定一个上游和临床相关的指标,以确定与RVSP相比,LBBAP在防止TAVR后心室起搏负担重的患者左心室功能恶化方面的优势。
{"title":"Comparing Left Bundle Branch Area vs Right-Ventricular Septal Pacing in High-Degree Conduction Disease After Transcatheter Aortic Valve Replacement: Randomized Trial Study Protocol","authors":"","doi":"10.1016/j.cjco.2024.05.006","DOIUrl":"10.1016/j.cjco.2024.05.006","url":null,"abstract":"<div><p>Left bundle branch area pacing (LBBAP) is a novel method of conduction-system pacing in the muscular interventricular septum. Although LBBAP has been shown to produce physiologic electrical and mechanical intraventricular synchrony, superiority of LBBAP, compared to right ventricular septal pacing (RVSP) at preserving normal left-ventricular (LV) systolic function after transcatheter aortic valve replacement (TAVR) has not been demonstrated. Left Bundle BRAVE is an investigator-initiated, multicentre, prospective, double-blinded, randomized, crossover study investigating the superiority of LBBAP, compared to RVSP, with respect to preservation of systolic function in patients with high-degree conduction disease after TAVR. Adults with severe aortic stenosis and normal systolic function who sustain high-grade atrioventricular block within 4 weeks of TAVR are eligible. All subjects receive a biventricular pacemaker generator with RVSP, and LBBAP leads. Participants are randomly assigned to 9 months of each pacing mode, in series. The primary endpoint is change in global longitudinal strain, tested in series with change in LV ejection fraction, comparing RVSP to LBBAP. Secondary endpoints include the following: echocardiographic markers of interventricular synchrony and right ventricular performance; heart failure functional status and symptom classification; 6-minute walk test results; pacemaker and lead performance; and brain natriuretic peptide concentration. The Left Bundle BRAVE study is designed to identify an upstream and clinically relevant marker of superiority in LBBAP, compared to RVSP, at preventing deterioration of LV function in patients with a high ventricular pacing burden after TAVR.</p></div><div><h3>ClinicalTrials.gov identifier</h3><p>NCT05541679</p></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24002166/pdfft?md5=41919ab37a9b28b63927c797255e6ee2&pid=1-s2.0-S2589790X24002166-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141130721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac Safety of Ozanimod Use, a Novel Sphingosine-1-Phosphate Receptor Ligand, in COVID-19 Patients Requiring Oxygen: Secondary Analysis of the COZI Randomized Clinical Trial 新型鞘氨醇-1-磷酸受体配体奥扎莫德在需要吸氧的 COVID-19 患者中的心脏安全性
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.05.002

Background

Ozanimod is a novel immune modulator that could be useful in viral pulmonary infections by reducing lung inflammation. It is an S1P receptor ligand known to induce bradycardia and more serious adverse cardiac effects, such as atrioventricular block and QT interval prolongation. We present a substudy of the COVID-19 Ozanimod Intervention (COZI) trial in which ozanimod was administered in acute pulmonary infection patients, to assess cardiac safety.

Methods

In this pilot randomized open-label trial, COVID-19 patients requiring oxygen support were randomized into 2 groups: standard-of-care + ozanimod (OZA) vs standard-of-care alone (SOC). All patients were monitored with a 14-day electrocardiogram monitor (CardioSTAT, Icentia, Quebec, QC) during their hospitalization. We evaluated the cardiac effects of ozanimod on heart rate (HR), PR interval length, and QT interval duration.

Results

A total of 42 patients were analyzed: 23 in the SOC group and 19 in the OZA group. Mean hourly HR over the first 10 days of treatment decreased in the OZA group, compared with that in the SOC group (P < 0.0001). The maximum decrease in HR occurred on day 3. The maximum decrease in HR occurred on day 3, without a significant difference between groups: 49 beats per minute (interquartile range, 42-59) in the OZA group, and 54 beats per minute (48–60) in the SOC group, P = 0.45. No high-degree atrioventricular block was recorded. QT and PR interval median values were within the normal range in both groups, without a significant difference.

Conclusions

The maximal reduction in HR occurred 3 days after the onset of ozanimod treatment in patients hospitalized for COVID-19, but it did not remain significant over the 10-day treatment period. No relevant cardiac adverse event was observed.

背景奥扎莫德是一种新型免疫调节剂,可通过减轻肺部炎症来治疗病毒性肺部感染。它是一种 S1P 受体配体,已知会诱发心动过缓和更严重的心脏不良反应,如房室传导阻滞和 QT 间期延长。在这项随机开放标签试验中,需要氧气支持的 COVID-19 患者被随机分为两组:标准护理 + 奥扎莫德 (OZA) 与单独标准护理 (SOC)。所有患者在住院期间都接受了为期 14 天的心电图监测(CardioSTAT,Icentia 公司,魁北克省)。我们评估了奥扎莫德对心率(HR)、PR 间期长度和 QT 间期持续时间的影响。与 SOC 组相比,OZA 组在治疗的前 10 天内平均每小时心率下降(P < 0.0001)。心率的最大降幅出现在第 3 天。心率的最大降幅出现在第 3 天,组间差异不显著:OZA 组为每分钟 49 次(四分位间范围,42-59),SOC 组为每分钟 54 次(48-60),P = 0.45。没有记录到高度房室传导阻滞。两组的 QT 和 PR 间期中位值均在正常范围内,无显著差异。结论 COVID-19 住院患者在开始奥扎莫德治疗 3 天后心率下降达到最大值,但在 10 天的治疗期间心率下降并不显著。未观察到相关的心脏不良事件。
{"title":"Cardiac Safety of Ozanimod Use, a Novel Sphingosine-1-Phosphate Receptor Ligand, in COVID-19 Patients Requiring Oxygen: Secondary Analysis of the COZI Randomized Clinical Trial","authors":"","doi":"10.1016/j.cjco.2024.05.002","DOIUrl":"10.1016/j.cjco.2024.05.002","url":null,"abstract":"<div><h3>Background</h3><p>Ozanimod is a novel immune modulator that could be useful in viral pulmonary infections by reducing lung inflammation. It is an S1P receptor ligand known to induce bradycardia and more serious adverse cardiac effects, such as atrioventricular block and QT interval prolongation. We present a substudy of the <strong>C</strong>OVID-19 <strong>Oz</strong>animod <strong>I</strong>ntervention (COZI) trial in which ozanimod was administered in acute pulmonary infection patients, to assess cardiac safety.</p></div><div><h3>Methods</h3><p>In this pilot randomized open-label trial, COVID-19 patients requiring oxygen support were randomized into 2 groups: standard-of-care + ozanimod (OZA) vs standard-of-care alone (SOC). All patients were monitored with a 14-day electrocardiogram monitor (CardioSTAT, Icentia, Quebec, QC) during their hospitalization. We evaluated the cardiac effects of ozanimod on heart rate (HR), PR interval length, and QT interval duration.</p></div><div><h3>Results</h3><p>A total of 42 patients were analyzed: 23 in the SOC group and 19 in the OZA group. Mean hourly HR over the first 10 days of treatment decreased in the OZA group, compared with that in the SOC group (<em>P</em> &lt; 0.0001). The maximum decrease in HR occurred on day 3. The maximum decrease in HR occurred on day 3, without a significant difference between groups: 49 beats per minute (interquartile range, 42-59) in the OZA group, and 54 beats per minute (48–60) in the SOC group, <em>P</em> = 0.45. No high-degree atrioventricular block was recorded. QT and PR interval median values were within the normal range in both groups, without a significant difference.</p></div><div><h3>Conclusions</h3><p>The maximal reduction in HR occurred 3 days after the onset of ozanimod treatment in patients hospitalized for COVID-19, but it did not remain significant over the 10-day treatment period. No relevant cardiac adverse event was observed.</p></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24002129/pdfft?md5=92f1fbffaa8f6a3a1bb60c8070785f0f&pid=1-s2.0-S2589790X24002129-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141029005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Features of Calcific Aortic Stenosis in Female and Male Patients 女性和男性钙化性主动脉瓣狭窄的分子特征
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.06.002

Over the past 15 years, sex-related differences in aortic valve (AV) stenosis (AS) have been highlighted, affecting various aspects of AS, such as the pathophysiology, AV lesions, left ventricle remodelling, and outcomes. Female patients were found to present a more profibrotic pattern of leaflet remodelling and/or thickening, whereas male patients have a preponderance of calcification within stenosed leaflets. The understanding of these sex differences is still limited, owing to the underrepresentation of female patients in many basic and clinical research studies and trials. A better understanding of sex differences in the pathophysiology of AS may highlight new therapeutic targets that potentially could be sex-specific. This review aims to summarize sex-related differences in AS, as discovered from basic research experiments, covering aspects of the disease ranging from leaflet composition to signalling pathways, sex hormones, genetics and/or transcriptomics, and potential sex-adapted medical treatments.

在过去的 15 年中,主动脉瓣狭窄(AV)中与性别有关的差异得到了强调,这些差异影响着主动脉瓣狭窄的各个方面,如病理生理学、AV 病变、左心室重塑和预后。研究发现,女性患者的瓣叶重塑和/或增厚更多表现为深纤维化模式,而男性患者的狭窄瓣叶钙化则更多。由于女性患者在许多基础和临床研究及试验中的代表性不足,人们对这些性别差异的了解仍然有限。更好地了解强直性脊柱炎病理生理学中的性别差异可能会突出新的治疗靶点,这些靶点可能具有性别特异性。本综述旨在总结从基础研究实验中发现的强直性脊柱炎与性别有关的差异,涉及疾病的各个方面,从小叶组成到信号通路、性激素、遗传学和/或转录组学,以及潜在的性别适应性医疗。
{"title":"Molecular Features of Calcific Aortic Stenosis in Female and Male Patients","authors":"","doi":"10.1016/j.cjco.2024.06.002","DOIUrl":"10.1016/j.cjco.2024.06.002","url":null,"abstract":"<div><p>Over the past 15 years, sex-related differences in aortic valve (AV) stenosis (AS) have been highlighted, affecting various aspects of AS, such as the pathophysiology, AV lesions, left ventricle remodelling, and outcomes. Female patients were found to present a more profibrotic pattern of leaflet remodelling and/or thickening, whereas male patients have a preponderance of calcification within stenosed leaflets. The understanding of these sex differences is still limited, owing to the underrepresentation of female patients in many basic and clinical research studies and trials. A better understanding of sex differences in the pathophysiology of AS may highlight new therapeutic targets that potentially could be sex-specific. This review aims to summarize sex-related differences in AS, as discovered from basic research experiments, covering aspects of the disease ranging from leaflet composition to signalling pathways, sex hormones, genetics and/or transcriptomics, and potential sex-adapted medical treatments.</p></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24002506/pdfft?md5=8439170e3d9803b4e4aa05a22494d653&pid=1-s2.0-S2589790X24002506-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid DNA Diagnosis of Familial Hypercholesterolemia Due to the LDLR 15.8-Kilobase Deletion 快速 DNA 诊断 LDLR 15.8 kb 缺失导致的家族性高胆固醇血症
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.06.001
{"title":"Rapid DNA Diagnosis of Familial Hypercholesterolemia Due to the LDLR 15.8-Kilobase Deletion","authors":"","doi":"10.1016/j.cjco.2024.06.001","DOIUrl":"10.1016/j.cjco.2024.06.001","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X2400249X/pdfft?md5=0bdf8382453008b357fb18c2dc76190b&pid=1-s2.0-S2589790X2400249X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141403792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of a Mobile, Cloud-Based Care-Coordination Platform on Door-to-Balloon Time in Patients With STEMI: Initial Results 基于云的移动护理协调平台对 STEMI 患者 "门到气球 "时间的影响:初步结果
IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.cjco.2024.05.011

Care-coordination platforms may optimize ST-elevation myocardial infarction (STEMI) treatment delays. This study aimed to assess the impact of Stenoa use on treatment delays in STEMI patients. We conducted a retrospective cohort study on local STEMI cases for the period between September 2020 and March 2023, comparing the times from first medical contact to device, before vs after the implementation of the Stenoa platform by the catheterization laboratory (cath-lab) and emergency department. A total of 180 patients were included. Significant reductions were found in times from first medical contact to electrocardiogram, from electrocardiogram to cath-lab activation, and from cath-lab activation to cath-lab arrival (P = 0.02, P = 0.04, and P = 0.02, respectively), after the platform was implemented. These findings suggest that use of Stenoa reduces STEMI door-to-balloon–time components.

护理协调平台可优化ST段抬高型心肌梗死(STEMI)的治疗延迟。本研究旨在评估 STenoa 的使用对 STEMI 患者治疗延迟的影响。我们对 2020 年 9 月至 2023 年 3 月期间的当地 STEMI 病例进行了一项回顾性队列研究,比较了导管室(cath-lab)和急诊科实施 Stenoa 平台前后从首次医疗接触到设备的时间。共纳入 180 名患者。结果发现,在实施该平台后,从首次医疗接触到心电图检查、从心电图检查到导管室启动以及从导管室启动到导管室到达的时间均有显著缩短(分别为 P = 0.02、P = 0.04 和 P = 0.02)。这些研究结果表明,使用 Stenoa 缩短了 STEMI 门到气管插管时间。
{"title":"Impact of a Mobile, Cloud-Based Care-Coordination Platform on Door-to-Balloon Time in Patients With STEMI: Initial Results","authors":"","doi":"10.1016/j.cjco.2024.05.011","DOIUrl":"10.1016/j.cjco.2024.05.011","url":null,"abstract":"<div><p>Care-coordination platforms may optimize ST-elevation myocardial infarction (STEMI) treatment delays. This study aimed to assess the impact of Stenoa use on treatment delays in STEMI patients. We conducted a retrospective cohort study on local STEMI cases for the period between September 2020 and March 2023, comparing the times from first medical contact to device, before vs after the implementation of the Stenoa platform by the catheterization laboratory (cath-lab) and emergency department. A total of 180 patients were included. Significant reductions were found in times from first medical contact to electrocardiogram, from electrocardiogram to cath-lab activation, and from cath-lab activation to cath-lab arrival (<em>P</em> = 0.02, <em>P</em> = 0.04, and <em>P</em> = 0.02, respectively), after the platform was implemented. These findings suggest that use of Stenoa reduces STEMI door-to-balloon–time components.</p></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24002233/pdfft?md5=9f09afd49adc5acabfa5f66d8ef58269&pid=1-s2.0-S2589790X24002233-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
CJC Open
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1