Obesity Medicine最新文献_第7页

Evolving paradigms in nutrition therapy for Diabetes: From carbohydrate counting to precision diets 糖尿病营养治疗的进化范式：从碳水化合物计数到精确饮食

Q2 Medicine

Obesity Medicine

Pub Date : 2025-06-09 DOI: 10.1016/j.obmed.2025.100622

Esther Ugo Alum , David Chukwu Obasi , Jacinta Nnennaya Abba , Ugonna Cassandra Aniokete , Prince Nkemakolam Okoroh , Ada Ak Akwari

The global prevalence of diabetes is on the rise, necessitating advanced strategies for effective management. Nutrition therapy plays a critical role in managing diabetes, contributing to glycemic control, weight regulation, and complication prevention. Historically centered around carbohydrate counting and standardized meal plans, nutrition strategies have evolved toward more flexible, patient-centered approaches. Emerging evidence underscores the importance of individualized dietary interventions tailored to patients’ cultural preferences, metabolic profiles, and comorbid conditions. Approaches such as the Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH), and plant-based diets have demonstrated significant benefits in both type 1 and type 2 diabetes. The integration of digital tools, behavioral science, and emerging insights from nutrigenomics and the gut microbiome further supports a paradigm shift toward precision nutrition. In this commentary, we highlight the evolution of nutrition therapy in diabetes care, emphasizing the transition from generic recommendations to personalized dietary strategies aimed at improving long-term outcomes. It emphasizes the potential of precision nutrition to optimize glycemic control, mitigate complications, and improve patient adherence. We argue that the future of diabetes care depends on a personalized nutrition model that accounts for metabolic individuality, cultural context, and digital health integration. Our discussion highlights a critical transition in practice and research priorities, offering a timely framework for clinicians and policymakers navigating the evolving landscape of diabetes management. Peer-reviewed articles, clinical guidelines, and systematic reviews were sourced from databases such as PubMed, Scopus, and Google Scholar. The analysis focused on studies evaluating carbohydrate counting, personalized nutrition, and their respective impacts on glycemic control and patient outcomes. Key topics included advancements in nutrigenomics, metabolomics, and the integration of precision medicine in dietary interventions. The findings were synthesized to highlight current challenges, emerging trends, and potential solutions in implementing personalized nutrition strategies for diabetes care.

全球糖尿病患病率呈上升趋势，需要先进的策略进行有效的管理。营养治疗在糖尿病治疗中起着至关重要的作用，有助于血糖控制、体重调节和并发症预防。历史上以碳水化合物计数和标准化膳食计划为中心，营养策略已经向更灵活、以患者为中心的方法发展。新出现的证据强调了根据患者的文化偏好、代谢特征和合并症进行个性化饮食干预的重要性。地中海饮食、停止高血压的饮食方法（DASH）和植物性饮食等方法已经证明对1型和2型糖尿病都有显著的益处。数字工具、行为科学以及营养基因组学和肠道微生物组的新见解的整合进一步支持了向精准营养的范式转变。在这篇评论中，我们强调了糖尿病护理中营养治疗的演变，强调了从通用推荐到个性化饮食策略的转变，旨在改善长期结果。它强调了精准营养在优化血糖控制、减轻并发症和提高患者依从性方面的潜力。我们认为，糖尿病护理的未来取决于个性化的营养模式，该模式考虑了代谢个性、文化背景和数字健康整合。我们的讨论强调了实践和研究重点的关键转变，为临床医生和政策制定者提供了一个及时的框架，以引导糖尿病管理的发展前景。同行评议的文章、临床指南和系统评论均来自PubMed、Scopus和谷歌Scholar等数据库。该分析侧重于评估碳水化合物计数、个性化营养及其各自对血糖控制和患者预后的影响的研究。主要议题包括营养基因组学、代谢组学的进展，以及精准医学在饮食干预中的整合。综合研究结果，突出当前的挑战，新趋势，和潜在的解决方案，在实施个性化的营养策略，糖尿病护理。

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引用次数: 0

Syzygium aromaticum loaded copper oxide nanoparticles ameliorates diabetic nephropathy by diminishing oxidative stress and inflammatory responses in Wistar rats 紫丁香载氧化铜纳米颗粒通过减少Wistar大鼠的氧化应激和炎症反应来改善糖尿病肾病

Q2 Medicine

Obesity Medicine

Pub Date : 2025-05-24 DOI: 10.1016/j.obmed.2025.100621

Momin Aramash , Manisha N. Chalse , Aniroodha V. Pethkar , Urmila M. Aswar

Background and aims

Diabetic nephropathy (DN) is a major disorder of prolonged diabetes mellitus (DM) which ends up in chronic renal failure. Here, we report the beneficial effects of copper oxide nanoparticles loaded with Syzygium aromaticum extract (SaCuONpls) on DN in Wistar rats. Syzygium aromaticum is a spice with numerous therapeutic uses. Altered copper concentration in the blood is responsible for various diseases and affects different organs. Moreover minor copper deficiencies can promote the progression of many pathologies including DM.

Methods

Diabetes induced nephropathy was produced by administration of nicotinamide and streptozotocin. Rats with a blood glucose of more than 250 mg/dL were considered hyperglycemic. Diabetic rats were left untreated for 42 days for the development of nephropathy that was characterized by a marked decline in urine creatinine levels and increased levels of microproteinuria. The nephropathic rats were orally treated with SaCuONpls (2.5, 5, and 10 mg/kg) and the standard drug, glimepiride (10 mg/kg) for 42 days. At the end of the experiment, the serum parameters, urine parameters, oxidative stress, and inflammatory markers were studied and kidneys were removed for histology (H&E, PAS, and MT staining).

Results

Treatment of SaCuONpls significantly improved the serum and urine biochemistry, antioxidant potential by increasing activity of SOD, CAT and GSH and declined the oxidative stress mediated by MDA and NO and the ameliorative effect of proinflammatory mediators (NF-κB, TNF-α, IL-1β and IL-6) was noticed. SaCuONpls mitigated adverse histopathological changes.

Conclusions

The therapeutic potential of SaCuONpls was ascertained by enhanced renal function.

背景与目的糖尿病肾病（DN）是长期糖尿病（DM）的主要疾病，最终发展为慢性肾功能衰竭。在这里，我们报道了氧化铜纳米颗粒负载丁香提取物（SaCuONpls）对Wistar大鼠DN的有益影响。香辛草是一种具有多种治疗用途的香料。血液中铜浓度的改变是导致多种疾病和影响不同器官的原因。此外，微量铜缺乏可促进包括糖尿病在内的多种疾病的进展。方法采用烟酰胺和链脲佐菌素诱导糖尿病肾病。血糖超过250毫克/分升的大鼠被认为是高血糖。糖尿病大鼠未经治疗42天，其肾病发展的特点是尿肌酐水平明显下降，微量蛋白尿水平升高。肾病大鼠分别口服SaCuONpls（2.5、5、10 mg/kg）和标准药物格列美脲（10 mg/kg）治疗42 d。实验结束时，检测大鼠血清参数、尿液参数、氧化应激、炎症指标，并取肾进行组织学检查（H&；E、PAS、MT染色）。结果SaCuONpls通过提高SOD、CAT和GSH活性，显著改善大鼠血清和尿液生化及抗氧化能力，降低MDA和NO介导的氧化应激，并对促炎介质NF-κB、TNF-α、IL-1β和IL-6有改善作用。SaCuONpls减轻了不良的组织病理学改变。结论SaCuONpls的治疗潜力是通过增强肾功能来确定的。

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引用次数: 0

Exploring uric acid as a biomarker in lipedema and lymphedema: A metabolomics study with prospective validation 探索尿酸作为脂水肿和淋巴水肿的生物标志物：一项具有前瞻性验证的代谢组学研究

Q2 Medicine

Obesity Medicine

Pub Date : 2025-05-01 DOI: 10.1016/j.obmed.2025.100618

Fahad Alkhalfan , Naseer Sangwan , Anu Aggarwal , Alliefair Scalise , José O. Alemán , Bhairavi Rajasekar , Douglas Joseph , Kimberly Peterson , Annelise Hamer , Mariya Ali , John R. Bartholomew , Scott J. Cameron

Aims

Lipedema is a condition often mistaken for other causes of limb swelling including lymphedema and obesity. Lipedema may have a unique metabolic profile. Interrogation of the metabolome is a strategy that could reveal unique biomarkers to distinguish lipedema from lymphedema and obesity.

Methods

Unbiased metabolomics was utilized to examine 38 BMI-matched overweight patients compared with patients with lipedema, lymphedema, and lipolymphedema. Machine learning identified biomarkers to distinguish diseases, and further examined in a validation cohort of 198 patients with each disorders. Adjustments were made for baseline clinical and demographic variables.

Results

Plasma metabolomics firstly revealed uric acid as a biomarker that performs well to distinguish between phenotypically similar diseases in patients with elevated BMI. In a validation cohort of 64 patients with lipedema, uric acid (5.05 mg/dL) was compared with 64 patients with lymphedema (5.4 mg/dl), and 70 overweight patients without these conditions (4.6 mg/dL, p < 0.05). Uric acid-to-cystatin c ratio distinguished between all three groups (Lipedema: 5.2; Lymphedema: 6.3; overweight: 4.0, p < 0.01); however, significance was lost after adjustment for renal function.

Conclusion

Metabolomic analysis revealed uric acid may differentiate between lipedema, lymphedema, lipolymphedema and obese individuals without those conditions. In a validation cohort, while uric acid was higher in lipedema and lymphedema, uric acid adjusted by cystatin c clearance revealed uric acid to be a less useful marker to distinguish lipedema from lymphedema in the context of renal insufficiency.

目的：肢体水肿是一种经常被误认为肢体肿胀的其他原因，包括淋巴水肿和肥胖。脂水肿可能具有独特的代谢特征。代谢组的询问是一种策略，可以揭示独特的生物标志物，以区分脂水肿、淋巴水肿和肥胖。方法采用偏倚代谢组学方法对38例bmi匹配的超重患者与脂性水肿、淋巴水肿和脂性水肿患者进行比较。机器学习识别生物标志物以区分疾病，并在每种疾病的198名患者的验证队列中进一步检查。对基线临床和人口统计学变量进行了调整。结果血浆代谢组学首次揭示了尿酸作为一种生物标志物，能够很好地区分BMI升高患者的表型相似疾病。在64例脂水肿患者的验证队列中，尿酸（5.05 mg/dL）与64例淋巴水肿患者（5.4 mg/dL）和70例没有这些情况的超重患者(4.6 mg/dL, p <；0.05)。尿酸与胱抑素c比值在三组之间的差异(脂水肿：5.2；淋巴水肿:6.3;超重：4.0,p <；0.01);然而，在调整肾功能后，其意义就失去了。结论代谢组学分析显示尿酸可区分脂肪水肿、淋巴水肿、脂肪水肿和肥胖个体。在一个验证队列中，虽然尿酸在脂水肿和淋巴水肿中较高，但通过胱抑素c清除调节的尿酸显示，在肾功能不全的情况下，尿酸作为区分脂水肿和淋巴水肿的一个不太有用的标志物。

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引用次数: 0

Diabetes mellitus, Obesity and Periodontitis – A three way interconnection

Q2 Medicine

Obesity Medicine

Pub Date : 2025-05-01 DOI: 10.1016/j.obmed.2025.100615

Pavithra Velusamy , Sri Chinthu Kenniyan Kumar , Monica Charlotte Solomon

Type 2 diabetes mellitus (T2DM) is the most common metabolic and endocrine disorder which causes a rise in blood glucose levels often attributed to insulin resistance or relative insulin insufficiency. The listed complications T2DM include retinopathy, neuropathy, nephropathy, stroke, and peripheral vascular diseases. Apart from these patients having uncontrolled and longstanding T2DM are prone to various cardiovascular disorders and oral diseases. Periodontitis, which involves inflammation of the periodontal ligament and alveolar bone has been listed as the sixth complication of diabetes mellitus for decades. Obesity is a serious social problem and is ranked as the fifth leading cause of mortality worldwide. Insulin resistance makes obesity a major risk factor for T2DM. Diabetes mellitus further adds to the periodontal tissue destruction. The hormones and cytokines in obese persons produce a series of inflammatory reactions that aid in developing periodontal disease. There are several studies linking the inflammatory triad between obesity, diabetes mellitus, and periodontitis. This review elucidates the interconnection between T2DM, obesity, and periodontitis.

2型糖尿病（T2DM）是一种最常见的代谢和内分泌紊乱，通常由胰岛素抵抗或相对胰岛素不足引起血糖水平升高。T2DM的并发症包括视网膜病变、神经病变、肾病、中风和周围血管疾病。除此之外，长期不受控制的T2DM患者还容易发生各种心血管疾病和口腔疾病。牙周炎，包括牙周韧带和牙槽骨的炎症，几十年来一直被列为糖尿病的第六大并发症。肥胖是一个严重的社会问题，是全球第五大致死原因。胰岛素抵抗使肥胖成为2型糖尿病的主要危险因素。糖尿病进一步加重了牙周组织的破坏。肥胖的人体内的激素和细胞因子会产生一系列炎症反应，从而导致牙周病的发生。有几项研究将肥胖、糖尿病和牙周炎三者之间的炎症联系起来。这篇综述阐明了T2DM、肥胖和牙周炎之间的联系。

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引用次数: 0

Exploring female infertility: A comprehensive review of polycystic ovary syndrome (PCOS) and its impact on reproductive health 探讨女性不孕症：多囊卵巢综合征（PCOS）及其对生殖健康影响的综合综述

Q2 Medicine

Obesity Medicine

Pub Date : 2025-05-01 DOI: 10.1016/j.obmed.2025.100619

Suparna Parua , Mahuya Patra Purkait , Aniruddha Bhattacharjee , Rajesh Thangarajan , Subramanian Rammohan , Kamirul Islam , Koushik Bhattacharya , Alak Kumar Syamal

Polycystic ovary syndrome (PCOS), a complicated endocrine disorder that causes female infertility, affects 6–10 % of reproductive-age women. Although it is necessary to intricate the relationship between PCOS and reproductive health to illuminate how it affects female fertility. Pathophysiology describing that how the hormonal imbalances cause ovarian cyst formation following clinical issues in ovulation. These imbalances include low FSH, high LH, and high androgens as well as increased AMH, all of which disrupt normal follicular development and ovulation. PCOS related metabolic problems such insulin resistance, obesity, and dyslipidaemia have been carefully investigated for reproductive health implications along with the pharmacological aspects. The effects of oral contraceptives, anti-androgens (such as spironolactone), and insulin-sensitizing drugs (such as metformin) on ovulation and fertility heve been reviewed. This article examines the use of the Rotterdam criteria and imaging techniques such as transvaginal ultrasound for diagnosing PCOS, while also exploring comprehensive management strategies including pharmacological treatments, alternative medicine approach and lifestyle modifications like diet and exercise to improve metabolic and reproductive outcomes. Besides those explorations of emerging treatments and early-stage studies for PCOS, including the potential of supplementary therapies like myo-inositol and lifestyle modifications tailored to individual metabolic profiles. It also highlights the latest studies on the factors contributing to PCOS and their implications for personalized treatment approaches. Emphasizing the importance of a holistic management plan, the article addresses both physical and emotional well-being, including the psychosocial impact of PCOS on mental health and overall quality of life.

多囊卵巢综合征（PCOS）是一种导致女性不孕的复杂内分泌紊乱，影响了6 - 10%的育龄妇女。虽然多囊卵巢综合征与生殖健康之间的关系错综复杂，以阐明其如何影响女性生育能力是必要的。病理生理学描述如何荷尔蒙失衡导致卵巢囊肿形成后的临床问题排卵。这些失衡包括低FSH，高LH，高雄激素以及AMH增加，所有这些都会破坏正常的卵泡发育和排卵。多囊卵巢综合征相关的代谢问题，如胰岛素抵抗、肥胖和血脂异常，已经被仔细研究了生殖健康的影响以及药理学方面。口服避孕药、抗雄激素（如螺内酯）和胰岛素增敏药物（如二甲双胍）对排卵和生育的影响已经进行了综述。本文探讨了使用鹿特丹标准和经阴道超声等成像技术诊断多囊卵巢综合征，同时也探讨了综合管理策略，包括药物治疗，替代医学方法和生活方式的改变，如饮食和运动，以改善代谢和生殖结果。除了对多囊卵巢综合征的新兴治疗方法和早期研究的探索，包括潜在的补充疗法，如肌醇和针对个人代谢特征的生活方式改变。它还重点介绍了导致多囊卵巢综合征的因素及其对个性化治疗方法的影响的最新研究。文章强调了整体管理计划的重要性，涉及身体和情感健康，包括多囊卵巢综合征对心理健康和整体生活质量的心理社会影响。

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引用次数: 0

Mechanistic insights into the anti-obesity actions of coumarins: Therapeutic potential and future directions 香豆素抗肥胖作用的机制：治疗潜力和未来方向

Q2 Medicine

Obesity Medicine

Pub Date : 2025-05-01 DOI: 10.1016/j.obmed.2025.100620

Yasser Fakri Mustafa

Obesity is a complex and chronic metabolic disorder characterized by excessive fat accumulation, leading to severe health complications such as diabetes, cardiovascular diseases, and metabolic syndromes. Traditional drug and lifestyle changes can help, but they have problems like side effects and don't work for a long time, so people need to look for other ways to treat their conditions. Coumarins, a diverse class of naturally occurring polyphenolic compounds, have garnered significant attention for their potential anti-obesity effects. This review systematically explores the mechanistic pathways of coumarins—including their modulation of lipid metabolism, glucose homeostasis, thermogenic activity, inflammation, and adipogenic signaling—highlighting their multifaceted role in combating obesity. Preclinical studies show that coumarins stop adipocytes from differentiating, speed up lipolysis, and manage key metabolic pathways involving adiponectin, AMPK, and PPARγ. New evidence also suggests that coumarins change the composition of the gut microbiota, which adds to their ability to handle obesity. However, clinical evidence remains limited, with only a few studies investigating their efficacy in human populations. Safety considerations, including potential hepatotoxicity and anticoagulant effects, also necessitate careful evaluation. Future research should focus on optimizing coumarin derivatives, elucidating their precise mechanisms, and conducting large-scale clinical trials to establish their therapeutic potential. This review shows that coumarins have a lot of potential as natural weight loss aids, but more research is needed before these results can be used in patients.

肥胖是一种复杂的慢性代谢紊乱，其特征是脂肪过度积累，导致严重的健康并发症，如糖尿病、心血管疾病和代谢综合征。传统的药物和生活方式的改变可以有所帮助，但它们有副作用等问题，而且长期不起作用，所以人们需要寻找其他方法来治疗他们的病情。香豆素是一种多种天然多酚类化合物，因其潜在的抗肥胖作用而受到广泛关注。这篇综述系统地探讨了香豆素的机制途径，包括它们对脂质代谢、葡萄糖稳态、产热活性、炎症和脂肪生成信号的调节，强调了它们在对抗肥胖中的多方面作用。临床前研究表明，香豆素可以阻止脂肪细胞分化，加速脂肪分解，并管理包括脂联素、AMPK和PPARγ在内的关键代谢途径。新的证据还表明，香豆素可以改变肠道微生物群的组成，从而增强它们应对肥胖的能力。然而，临床证据仍然有限，只有少数研究调查了它们在人群中的功效。安全性方面的考虑，包括潜在的肝毒性和抗凝作用，也需要仔细评估。未来的研究应集中在优化香豆素衍生物，阐明其确切的机制，并进行大规模的临床试验，以确定其治疗潜力。这篇综述表明，香豆素作为天然减肥辅助药物有很大的潜力，但在这些结果可以用于患者之前，还需要更多的研究。

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引用次数: 0

Exploring the anti-diabetic potential of Ulva lactuca flavonoids in a Drosophila model 探索芦荟黄酮类化合物在果蝇模型中的抗糖尿病作用

Q2 Medicine

Obesity Medicine

Pub Date : 2025-05-01 DOI: 10.1016/j.obmed.2025.100616

Sotubdhi Sharma , Asif Mahmud , Md Amjad Patwary , Mantasha Mahmud Hia , Sobnom Mustari Shukti , Nusrat Jahan Tisha , Zobada Kanak Khan , Md Faruque Miah

Aims

The study aimed to evaluate the anti-diabetic potential of Ulva lactuca crude flavonoids by assessing their effects on external morphology and hemolymph glucose concentrations in Drosophila melanogaster under various dietary conditions, including a high-sugar diet.

Methods

Four dietary conditions were tested in D. melanogaster to assess the effects of U. lactuca crude flavonoids: control diet, high-sugar diet, high-sugar with standard diet, and diets with flavonoid concentrations (0.1M, 0.2M, 0.3M). External morphology and hemolymph glucose concentrations were evaluated.

Results

Hemolymph glucose concentrations were found 0.045 mg/mL in the high-sugar group and 0.054 mg/mL in the sugar-with-standard diet group, compared to 0.016 mg/mL in control flies. Flavonoid treatments reduced glucose levels in a dose-dependent manner, with 0.1M, 0.2M, and 0.3M flavonoid concentrations lowering glucose to 0.038 mg/mL, 0.035 mg/mL, and 0.017 mg/mL, respectively. The highest concentration (0.3M) nearly restored glucose levels to those of the control, along with a significant decrease in both abdominal width (0.87 ± 0.03 mm) and body weight (1.27 ± 0.04 mg).

Conclusion

U. lactuca flavonoids effectively reduced glucose levels and mitigated obesity in sugar-treated D. melanogaster, suggesting their potential as safe dietary interventions for metabolic disorders like diabetes.

目的通过观察不同饮食条件（包括高糖饮食）对黑腹果蝇体外形态和血淋巴葡萄糖浓度的影响，探讨黑腹Ulva lactuca粗黄酮的抗糖尿病潜力。方法采用对照日粮、高糖日粮、高糖标准日粮和黄酮浓度（0.1M、0.2M、0.3M）日粮4种饲料条件，对黑腹巨蛋粗黄酮的影响进行评价。观察外部形态学和血淋巴葡萄糖浓度。结果高糖组和标准糖组小鼠淋巴细胞葡萄糖浓度分别为0.045 mg/mL和0.054 mg/mL，对照组为0.016 mg/mL。黄酮类化合物处理以剂量依赖性方式降低葡萄糖水平，0.1M、0.2M和0.3M黄酮类化合物浓度分别使葡萄糖降低0.038 mg/mL、0.035 mg/mL和0.017 mg/mL。最高浓度（0.3M）使血糖水平基本恢复到对照组水平，腹宽（0.87±0.03 mm）和体重（1.27±0.04 mg）均显著降低。在糖处理过的黑腹龙葵中，黄酮类化合物有效地降低了葡萄糖水平，减轻了肥胖，这表明它们有可能作为糖尿病等代谢紊乱的安全饮食干预措施。

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引用次数: 0

Effects of high fat diet on blood lipids and liver enzymes in murine model: the systemic and experimental study 高脂饮食对小鼠血脂及肝酶的影响：系统与实验研究

Q2 Medicine

Obesity Medicine

Pub Date : 2025-05-01 DOI: 10.1016/j.obmed.2025.100614

Thuy-Duong Vu , Anh-Dao Ngo , Son-Tung Nguyen , Yen-Nhi Khuong , Van-Bao Phan , Tien-Dat Pham , Duc-Anh Le , Thanh-Thuy To , Chia-Ching Wu , Dinh-Toi Chu

Background

A high fat diet is associated various metabolic disorders, including fatty liver disease and dyslipidemia. This work is aimed to examine effects of excess lard usage from diet on blood lipids and liver enzymes in murine models in the aspects of genetics and food types.

Methods

A systematic review was conducted to form a general picture of the effects of high fat diet (HFD) on blood lipid and liver enzyme profiles of mice and compare these indices between study designs. At the same time, 24 Swiss albino mice were included in an experimental study, two groups with different diets (HFD and standard diet - STD) in 18 weeks to examine serum levels of liver enzymes and blood lipids.

Results

Our results in the systematic review indicate that HFD from lard increased TG, TC, LDL-C, ALT indexes in the majority of studies. C57BL/6 strain was used the most as well as being seen as the best results in these studies. In addition, the most popular types of HFD used in these results were HFD 60 % and HFD 45 %. They also showed the most appropriate results, in which those related to HFD 60 % had lower dispersion than those of HFD 40 %. The change in blood lipids and serum liver enzymes due to HFD from lard also varied among studies using the same strain as well as different strains, especially that of HDL-C and AST. Our experiment on Swiss mice confirmed these results. After 18 weeks eating HFD, mice gained weight and accumulated white fat. All four indices of blood lipids including TC, TG, HDL-C and LDL-C of HFD group were significantly higher than STD group, with 15.90 %, 28.49 %, 20.12 % and 41.79 %, respectively. Although AST level did not show a difference between two groups, HFD leads to a 1.29-fold-increase in ALT level in mice.

Conclusion

In conclusion, both our systematic and experimental results indicate that HFD can increase blood lipids and liver enzymes in mice, and systematic analysis suggests that dyslipidemia and detrimental effects on the liver by HFD are depending on the animal genetics and types of diet.

背景：高脂肪饮食与多种代谢紊乱有关，包括脂肪肝和血脂异常。本研究旨在从遗传学和食物类型方面研究饮食中过量使用猪油对小鼠血脂和肝酶的影响。方法对高脂饮食对小鼠血脂和肝酶谱的影响进行系统评价，并在不同的研究设计之间进行比较。同时，24只瑞士白化病小鼠被纳入一项实验研究，两组在18周内采用不同的饮食（HFD和标准饮食- STD）来检测血清肝酶和血脂水平。结果我们的系统综述结果表明，在大多数研究中，来自猪油的HFD增加了TG、TC、LDL-C、ALT指标。C57BL/6菌株在这些研究中使用最多，效果最好。此外，在这些结果中，最常用的HFD类型是HFD 60%和HFD 45%。他们还显示了最合适的结果，即与HFD 60%相关的患者的弥散度低于HFD 40%相关的患者。来自猪油的HFD引起的血脂和血清肝酶的变化在使用同一菌株和不同菌株的研究中也有所不同，特别是HDL-C和AST。我们在瑞士小鼠身上的实验证实了这些结果。食用HFD 18周后，小鼠体重增加，白色脂肪堆积。HFD组的TC、TG、HDL-C、LDL-C 4项血脂指标均显著高于STD组，分别为15.90%、28.49%、20.12%、41.79%。虽然两组间谷丙转氨酶水平没有差异，但HFD导致小鼠谷丙转氨酶水平升高1.29倍。综上所述，我们的系统和实验结果都表明，HFD可以增加小鼠的血脂和肝酶，系统分析表明，HFD对肝脏的血脂异常和有害影响与动物的遗传和饮食类型有关。

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引用次数: 0

Major dietary patterns in candidates for bariatric surgery and their relationships with metabolic syndrome

Q2 Medicine

Obesity Medicine

Pub Date : 2025-05-01 DOI: 10.1016/j.obmed.2025.100612

Hastimansooreh Ansar , Negar Zamaninour , Gholamreza Mohammadi Farsani , Atefeh Seifollahi , Mohadeseh Hassan zadeh , Abdolreza Pazouki , Khadijeh Mirzaei , Ali Kabir

Background

The study examined 374 individuals who were candidates for bariatric surgery due to morbid obesity. The primary objective was to explore the significant dietary patterns and their potential correlation with metabolic syndrome (MetS).

Methods

Two distinct dietary patterns were determined in this cross-sectional study using principal components analysis: a healthy dietary pattern (HDP) that contains an abundance of fruits, veggies, and lean protein sources, and a western dietary pattern (WDP) that is identified by the intake of processed foods and high-fat items. The odds ratio was estimated using multivariate logistic regression.

Results

The findings showed a concerning link between the WDP and a reduced amount of high-density lipoprotein cholesterol (HDL-C), a crucial element of lipid metabolism and cardiovascular health. Conversely, the HDP did not show a significant link with MetS or its components in this cohort of individuals with morbid obesity.

Conclusion

These results underscore the potential adverse impact of a Western-style diet on metabolic health parameters, particularly HDL-C levels, in this population. The study highlights the importance of dietary patterns in influencing metabolic outcomes in individuals with morbid obesity and emphasizes that further researches may elucidate the interventions to reduce the risk of MetS in this high-risk group.

该研究调查了374名因病态肥胖而准备接受减肥手术的患者。主要目的是探索重要的饮食模式及其与代谢综合征（MetS）的潜在相关性。方法采用主成分分析的横断面研究确定了两种不同的饮食模式：一种是健康饮食模式（HDP），包含大量的水果、蔬菜和瘦肉蛋白来源，另一种是西方饮食模式（WDP），通过摄入加工食品和高脂肪食物来确定。比值比采用多元逻辑回归估计。结果：研究结果表明，WDP与高密度脂蛋白胆固醇（HDL-C）含量降低之间存在相关联系，高密度脂蛋白胆固醇是脂质代谢和心血管健康的关键因素。相反，在这组病态肥胖个体中，HDP没有显示出与MetS或其组成部分的显著联系。结论：这些结果强调了西式饮食对该人群代谢健康参数，特别是HDL-C水平的潜在不利影响。该研究强调了饮食模式在影响病态肥胖个体代谢结果中的重要性，并强调进一步的研究可能会阐明降低这一高危人群MetS风险的干预措施。

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引用次数: 0

Effectiveness of polyherbal formulation on Obesity: A review of preclinical and clinical trial studies 多药复方治疗肥胖的有效性：临床前和临床试验研究综述

Q2 Medicine

Obesity Medicine

Pub Date : 2025-05-01 DOI: 10.1016/j.obmed.2025.100617

Mozhgan Mohammadzadeh , Ali Shamsizadeh , Jalal Hassanshahi , Ayat Kaeidi , Mohammad-Reza Shafiepour

This comprehensive review delves into the potential of polyherbal formulations for obesity management, exploring the scientific evidence from preclinical and clinical trials. Given the global prevalence of obesity and the limitations of conventional treatments, the need for safe, effective, and holistic alternatives is paramount. Polyherbalism, leveraging the synergistic effects of multiple medicinal plants, offers a promising avenue for addressing this complex metabolic disorder.

这篇综合综述深入探讨了多草药配方对肥胖管理的潜力，探索了临床前和临床试验的科学证据。鉴于肥胖的全球流行和传统治疗的局限性，对安全、有效和全面的替代方案的需求是至关重要的。多草药疗法利用多种药用植物的协同作用，为解决这种复杂的代谢紊乱提供了一条有希望的途径。

引用次数: 0