Synergy最新文献

英文中文

THE RHETORIC OF CRISIS: POLITICAL COMMUNICATION ON SOCIAL NETWORKS DURING THE 2020 CORONAVIRUS OUTBREAK 危机的修辞:2020年冠状病毒爆发期间社交网络上的政治传播

Q2 Medicine

Synergy

Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.06

E. Antonia, Militaru Marina

The present paper analyses political communication on social platforms like Facebook, Twitter and Instagram during the 2020 coronavirus crisis. We are looking into the discourse of important political actors in the USA, Canada, France, the UK, the EU and Romania, attempting to highlight the rhetorical strategies they use to communicate with their audiences, to reassure them, to convince them that the crisis will be eventually overcome, to motivate and persuade them to comply with official regulations and to gain credibility and legitimacy for the policies enforced. The paper also provides an outline of the main advantages of using social platforms to reach the public, as well as of the most commonly used concepts and buzz-words that rhetors resort to in order to achieve their goals.

本文分析了2020年冠状病毒危机期间Facebook、Twitter和Instagram等社交平台上的政治传播。我们正在研究美国、加拿大、法国、英国、欧盟和罗马尼亚的重要政治行动者的话语，试图突出他们用于与受众沟通的修辞策略，让他们放心，让他们相信危机最终会被克服，激励和说服他们遵守官方规定，并为所执行的政策获得信誉和合法性。本文还概述了使用社交平台接触公众的主要优势，以及修辞家为了实现目标而诉诸的最常用概念和流行语。

引用次数: 0

QUELQUES RAMIFICATIONS TANGIBLES DE LA SOCIABILITÉ EN LIGNE: UN RAPPORT ENTRE VIE RÉELLE ET VIE VIRTUELLE DANS WORLD OF WARCRAFT 网络社交的一些有形后果:魔兽世界中现实生活和虚拟生活之间的关系

Q2 Medicine

Synergy

Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.04

Negrici Dominic

This one-off, largely exploratory study seeks to answer questions that map several basic phenomena of online sociability, in order to be able to have a basis for a possible analysis of the external cultural reception of an entity formed in a theoretically different culture – the Romanian culture. By going through the empirical inventory of some common typologies of online gamers, by means of randomized, anonymous interviews with players, our final goal (and hope) was to sketch a relationship between social capital and group configuration, within an internal community of the online game (MMORPG) World of Warcraft.

这个一次性的、主要是探索性的研究试图回答一些关于网络社交的基本现象的问题，以便能够为一个在理论上不同的文化中形成的实体的外部文化接受的可能分析提供基础-罗马尼亚文化。通过对在线玩家的一些常见类型进行实证调查，通过随机、匿名的玩家访谈，我们的最终目标(也是希望)是在在线游戏《魔兽世界》的内部社区中勾勒出社会资本和群体配置之间的关系。

引用次数: 0

FORGING A NEW TYPE OF FEMINIST IDENTITY: CHICANA FEMINISM, FEMININITY, AND THE INSTITUTION OF MEMORY 塑造一种新型的女性主义身份:墨西哥女性主义、女性气质和记忆制度

Q2 Medicine

Synergy

Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.01

Got Monica

Drawing on Jan Assmann’s interpretation of cultural memory as devoid of any racial/biological component, as well as James Clifford’s repudiation of the notion of cultural purity, the paper redefines memory as a mentally configured cultural institution, claiming that any reconfiguration of group identity is an act of symbolic violence. By emphasizing the crucial role that identity plays in understanding the fundamental themes tackled by Chicana literature—patriarchal oppression, racial terror, domestic abuse, sexism, homophobia—, the paper illustrates the extent to which the ethnic-gender binomial, i.e. belonging to a group that faces bias on various levels (femininity, Mexican American genealogy and, sporadically, sexual minority status), stands at the very core of the desire to redefine identity that largely fuels contemporary Chicana prose.

借鉴Jan Assmann对文化记忆的解释，即文化记忆没有任何种族/生物成分，以及James Clifford对文化纯洁性概念的否定，本文将记忆重新定义为一种心理配置的文化制度，声称任何群体身份的重新配置都是一种象征性暴力行为。通过强调身份在理解墨西哥文学所处理的基本主题——父权压迫、种族恐怖、家庭暴力、性别歧视、同性恋恐惧症——中所起的关键作用，本文阐明了种族-性别二元对立的程度，即属于一个在不同层面上面临偏见的群体(女性气质、墨西哥裔美国人的家谱，以及偶尔的性少数地位)，是重新定义身份的欲望的核心，这种欲望在很大程度上推动了当代墨西哥散文的发展。

引用次数: 0

THE TYRANNY OF MERIT: WHAT’S BECOME OF THE COMMON GOOD 功绩专制:公共利益变成了什么

Q2 Medicine

Synergy

Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.07

Marinescu Roxana-Elisabeta

引用次数: 217

10 SKILLS FOR EFFECTIVE BUSINESS COMMUNICATION. PRACTICAL STRATEGIES FOR THE WORLD’S GREATEST LEADERS 10个有效的商务沟通技巧。为世界上最伟大的领导人准备的实用策略

Q2 Medicine

Synergy

Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.08

Serban-Obrescu Anca-Teodora

引用次数: 0

PERSPECTIVES ADVANCED. STUDENT’S BOOK 视角先进。学生的书

Q2 Medicine

Synergy

Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.09

David Irina

引用次数: 0

MAY THE LOVE BE WITH YOU: FROM THE JOY OF LIFE TO THE TRANSCENDENCE OF EXISTENCE IN TAKAHATA ISAO’S ANIMATION WORKS 愿爱与你同在:高畑勋动画作品从生命的喜悦到存在的超越

Q2 Medicine

Synergy

Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.03

Grajdian Maria

From Ponpoko: The Heisei Tanuki War (1994), through My Neighbours, the Yamadas (1999), and until The Tale of Princess Kaguya (2013), the animation movies directed by the reputed animation director Takahata Isao (1935-2018) and released by Studio Ghibli since mid-1990s address the phenomenon of “life” as a meaningful endeavour towards attaining higher levels of human awareness. This occurs either by living in accordance with the flow of history, or by enjoying every moment as it comes, or, respectively, by delving into cosmic rhythms of imponderability: every single entity of existence delivers significance and comprehension, as displayed on multiple layers in the three animation works analyzed in this paper. Thus, in a phenomenological approach inspired by Julia Kristeva’s monumental publication La Révolution du langage poétique (1974) which views cultural products as mirroring channels of repression (Verdrängung) and desire (Begehren), the analysis draws on an anthropological framework in which the researcher functions as a dynamic, self-reflexive interface mediating between the self-ness of the theoretical structure (here: life and the quest for its significance) and the other-ness of the representation medium (here: Japanese animated works).

从《本坡子:平成Tanuki之战》(1994)，到《我的邻居》、《山田家》(1999)，再到《香谷公主的故事》(2013)，由著名动画导演高畑勲(1935-2018)执导、吉卜力工作室自20世纪90年代中期以来发行的动画电影将“生命”这一现象作为一种有意义的努力，以达到更高的人类意识水平。这可以通过按照历史的流动生活，或者通过享受每一个到来的时刻，或者分别通过探究不可估量的宇宙节奏来实现:每一个存在的实体都具有意义和理解，这在本文分析的三部动画作品中有多个层次的表现。因此，在Julia Kristeva的不朽著作《La r version du语言的自由变异》(1974)的启发下，采用现像学方法，将文化产品视为压抑(Verdrängung)和欲望(Begehren)的镜像渠道，分析借鉴了人类学框架，在该框架中，研究者作为动态的、自我反思的界面，在理论结构的自我性之间进行调解(这里:生活和对其意义的追求)以及表现媒介的他者性(这里是日本动画作品)。

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引用次数: 0

BETWEEN ‘CELESTIAL MAIDEN’ AND ‘SACRED PROSTITUTE’: THE MYTH OF THE DEVAͲDS5 IN THE IMAGINARY OF THE CONTEMPORARY INDIAN CLASSICAL DANCE PRACTITIONERS 在“天女”与“神圣妓女”之间:当代印度古典舞从业者想象中的devaͲds5神话

Q2 Medicine

Synergy

Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.05

M. Angelica

One of the most controversial discussions in the contemporary Indian arts environment remains the connection of the post-colonial classical dance practice with the DevadƗsƯ or the MaharƯ, the temple dancing girls. Born in the Early Medieval India, amidst and in close connection to the Bhakti and the Tantric movements, abiding in the temple institution, the so-called ‘DevadƗsƯ temple system’ remains a mystery, between awe and fascination to the nowadays practitioner and connaisseur of Indian arts. While tracing back the socio-religious contexts that brought the temple dancers on the foremost place of the stage of Indian art history, the author looks for the understanding of this myth in the imaginary and the reality of contemporary practitioners, from the perspective of a foreigner researcher-cum-practitioner of an Indian art form. The paper is based on consulting the existing literary sources concerning the DevadƗsƯ system, and the research is focusing on the nowadays classical dance practitioners’ imaginary (re)construction(s) of this system. Till today, here she stands, the woman-as-dance practitioner, either Indian or from any other part of the world, at the cross-road of all myths, imaginarily rooted in the past, but living all the aspirations of the nowadays social, cultural, religious, political dynamics, neither celestial maiden, nor sacred prostitute.

在当代印度艺术环境中，最具争议的讨论之一仍然是后殖民时期的古典舞蹈实践与DevadƗsƯ或MaharƯ，即寺庙舞蹈女孩之间的联系。出生于中世纪早期的印度，与巴克提和密宗运动密切相关，居住在寺庙制度中，所谓的“DevadƗsƯ寺庙系统”仍然是一个谜，对当今的实践者和印度艺术大师来说，它充满了敬畏和迷恋。在追溯将寺庙舞者带到印度艺术史舞台上最重要位置的社会宗教背景的同时，作者从一个印度艺术形式的外国研究者兼实践者的角度，在当代实践者的想象和现实中寻找对这一神话的理解。本文在查阅现有文献资料的基础上，重点研究当今古典舞从业者对DevadƗsƯ制度的想象(重构)。直到今天，她站在这里，作为舞蹈实践者的女人，无论是印度人还是来自世界其他地方的人，站在所有神话的十字路口，想象地植根于过去，但生活在当今社会，文化，宗教，政治动态的所有愿望，既不是天上的少女，也不是神圣的妓女。

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引用次数: 0

Predicting and understanding synergistic pairwise compound combinations of Shexian Baoxin Pill (SBP) using network biology 利用网络生物学预测和理解蛇仙保心丸(SBP)的协同配对组合

Q2 Medicine

Synergy

Pub Date : 2020-12-01 DOI: 10.1016/j.synres.2021.100073

Siti Zuraidah Mohamad Zobir , Ran Joo Choi , Dezso Modos , Tai-Ping Fan , Andreas Bender

The Traditional Chinese Medicine (TCM) formulation Shexiang Baoxin Pill (SBP) is commonly used in the treatment of coronary heart disease (CHD) in East Asia and regarded to promote the regulation of angiogenesis and to improve endothelial function. SBP comprises of seven TCM materials; however, the interactions of their effects in a biological system are unknown. In this work we developed an algorithm to predict the synergy of pairwise combinations of 22 compounds present in SBP. The algorithm is based on the targets of the compounds network properties in an angiogenesis- and CHD-specific network. We evaluated our synergy score prospectively by testing the 20 highest-ranked and the 20 lowest-ranked compound combinations for their synergistic potential to promote cell proliferation of human umbilical vascular endothelial cells. Results showed that 70 % of the 20 highest-ranked combinations increased cell proliferation synergistically, while only 30 % of the 20 lowest-ranked combinations had a synergistic effect. Based on the target and pathway predictions for the combinations, we hypothesized that two complementary pathways are responsible for the synergistic effect, apoptosis through caspase-3 and caspase-8 and cell growth through the proto-oncogene c-Fos and fibroblast growth factor 1. Hence, in this work we introduce an algorithm which was able to increase the probability of identifying compound pairs from SBP exhibiting synergy, which was experimentally validated in a disease-relevant model. Furthermore, we were able, based on this model, to provide a hypothesis for interactions causing synergy to promote endothelial cell growth.

蛇香保心丸(SBP)是东亚地区治疗冠心病(CHD)常用的中药制剂，被认为具有促进血管生成和改善内皮功能的作用。SBP由七种中药组成;然而，它们在生物系统中的相互作用是未知的。在这项工作中，我们开发了一种算法来预测存在于SBP中的22种化合物的成对组合的协同作用。该算法基于血管生成和冠心病特异性网络中化合物网络特性的目标。我们通过测试20个排名最高和20个排名最低的化合物组合来评估我们的协同作用评分，以促进人类脐带血管内皮细胞的细胞增殖。结果显示，在20个排名最高的组合中，70%的组合具有协同作用，而在20个排名最低的组合中，只有30%的组合具有协同作用。基于对这些组合的靶点和通路的预测，我们假设两个互补的通路负责协同作用，通过caspase-3和caspase-8进行细胞凋亡，通过原癌基因c-Fos和成纤维细胞生长因子1进行细胞生长。因此，在这项工作中，我们引入了一种算法，该算法能够增加从SBP中识别出具有协同作用的化合物对的概率，这在疾病相关模型中得到了实验验证。此外，基于该模型，我们能够提供一个相互作用导致协同作用促进内皮细胞生长的假设。

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引用次数: 1

Synergistic anti-cancer effect of pristimerin and docetaxel on human colorectal HCT-116 cells pritimerin和docetaxel对人结直肠癌HCT-116细胞的协同抗癌作用

Q2 Medicine

Synergy

Pub Date : 2020-12-01 DOI: 10.1016/j.synres.2020.100068

Bashir A. Yousef , Hozeifa M. Hassan , Muhanad Elhafiz , Luyong Zhang , Zhenzhou Jiang

Pristimerin is a quinonemethide triterpenoid compound that exerts anticancer activities against different cancer cells, including colorectal cancer. The current study aimed to study the cytotoxic and apoptosis-inducing effects of pristimerin alone or in combination with docetaxel on HCT-116 human colorectal cancer cell line. The cytotoxicity of pristimerin, or docetaxel, or the combination on HCT-116 cells were measured using the MTT method. The combination index (CI) was calculated using the isobologram method of Chou and Talalay. Annexin V/PI double staining was used to assess the apoptosis-inducing effect of these agents. Our results showed that both pristimerin and docetaxel showed potent cytotoxic effects against HCT-116 cells in dose-dependent manners. Moreover, the efficacy of docetaxel combined pristimerin was significantly increased, compared to individual treatment. The CI value was (0.55 to 0.89) that indicated the synergistic interaction between two agents to inhibit cell growth of CRC cells. Furthermore, Annexin V/PI assay showed that both agents induced apoptosis in HCT-116 in cancer cells. While treatment with combination resulted in a significant enhancement in apoptosis rates compared to individual treatment. Collectively, the data indicated that pristimerin potentiated the anticancer activities of docetaxel in colon cancer cells by reducing cell viability and promoting apoptosis.

pritimerin是一种醌类三萜化合物，对包括结直肠癌在内的不同癌细胞具有抗癌活性。本研究旨在研究普丽丝汀单用或联合多西他赛对HCT-116人结直肠癌细胞系的细胞毒性和诱导凋亡作用。采用MTT法检测普丽丝汀、多西紫杉醇或联合用药对HCT-116细胞的细胞毒性。采用Chou和Talalay等线图法计算组合指数(CI)。采用Annexin V/PI双染色法观察各药物的诱导凋亡作用。我们的研究结果表明，pritimerin和docetaxel对HCT-116细胞均表现出剂量依赖性的细胞毒性作用。此外，与单用治疗相比，多西他赛联合普瑞替林的疗效显著提高。CI值为(0.55 ~ 0.89)，表明两种药物协同作用抑制结直肠癌细胞的生长。此外，Annexin V/PI实验显示，两种药物均可诱导癌细胞HCT-116细胞凋亡。与单独治疗相比，联合治疗可显著提高细胞凋亡率。总的来说，这些数据表明，pritimerin通过降低细胞活力和促进细胞凋亡来增强多西紫杉醇在结肠癌细胞中的抗癌活性。

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