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Central and Eastern Europe: A crucible for clinical cancer innovation? 中欧和东欧:临床癌症创新的熔炉?
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-10-15 DOI: 10.1016/j.jcpo.2025.100647
Mark Lawler , Susan Bhatti , Pawel Przewiezlikowski , Birgit Wolf , Joanna Frątczak-Kazana , Piotr Rutkowski , Peter Šišovský , Lidia Zielińska , Axel Glasmacher
Clinical research in oncology is essential for improving patient outcomes; however, cancer care provision and access to novel therapies remains highly heterogeneous across Europe, particularly between Western and Eastern EU27 regions. This has been further compounded by the Russian invasion of Ukraine, severely disrupting regional cancer treatment, research infrastructures and clinical trials activity. Challenges to clinical research in the Central and Eastern regions of the European Union (EU27-CEE) are multifactorial, relating to patient access, local implementation and conduct of trials, education, infrastructure and regulatory procedures. Nevertheless, EU27-CEE comprises a very active clinical trial landscape with its specialist workforce, high productivity and quality of data, empowering a growing regional pharmaceutical industry and establishing itself as an important clinical cancer research hub for conducting global trials. Consequently, patients recruited in EU27-CEE exercise an important impact on global cancer drug development. Poland has proven to be a model for biomedical innovation, serving as the region’s blueprint for a productive clinical trials ecosystem. Multi-stakeholder collaboration and patient-centric approaches are required to streamline procedures for quicker trial initiation, simpler trial conduct, and better cross-border access. Recognizing these challenges and opportunities, we have developed, through a consultative approach, a Call to Action that, if implemented, would enhance the cancer clinical trials landscape in EU27-CEE countries and empower patient access to the latest advances and therapies in cancer drug development.
肿瘤学临床研究对改善患者预后至关重要;然而,癌症治疗的提供和新疗法的获得在整个欧洲,特别是在欧盟27国的西部和东部地区之间,仍然高度不同。俄罗斯入侵乌克兰进一步加剧了这种情况,严重破坏了区域癌症治疗、研究基础设施和临床试验活动。欧盟中部和东部地区(EU27-CEE)临床研究面临的挑战是多方面的,涉及患者可及性、试验的当地实施和开展、教育、基础设施和监管程序。尽管如此,欧盟27-中东欧地区拥有非常活跃的临床试验环境,拥有专业的劳动力、高生产率和高质量的数据,为不断增长的区域制药行业提供了动力,并将自己确立为开展全球试验的重要临床癌症研究中心。因此,在欧盟27-中东欧招募的患者对全球癌症药物开发具有重要影响。事实证明,波兰是生物医学创新的典范,是该地区高效临床试验生态系统的蓝图。需要多方利益攸关方合作和以患者为中心的方法来简化程序,以更快地启动试验,更简单地进行试验,并更好地跨境获取。认识到这些挑战和机遇,我们通过协商的方式制定了一项行动呼吁,如果实施,将加强欧盟27-中东欧国家的癌症临床试验环境,并使患者能够获得癌症药物开发的最新进展和治疗方法。
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引用次数: 0
Indirect economic burden of cancer in populations in China, 2021: A measurement based on a human capital approach 2021年中国癌症间接经济负担:基于人力资本方法的系统测量
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-10-15 DOI: 10.1016/j.jcpo.2025.100648
Xin-Yi Zhou , Xin Wang , Sen-Yao Cai , Yan-Jie Li , Jie-Bin Lew , Wanqing Chen , Ju-Fang Shi

Objectives

Cancer imposes an enormous burden. In China, research on cancer economic burden has primarily focused on the direct economic burden while the indirect economic burden of cancer (IEBC) has been overlooked. Therefore, we aimed to conduct a systematic quantification of IEBC in populations in China.

Methods

A human capital approach was used to estimate the IEBC. The loss of productivity time was approximated based on disability-adjusted life years (DALYs) from the GBD 2021. The labour force participation rate and per capita economic parameters were sourced from various datasets, and subgroup and sensitivity analyses were conducted. The indirect-to-direct economic burden ratio was estimated partially based on results from a literature review.

Results

The overall IEBC in populations in China was estimated to be CNY1014.4 billion in 2021, representing 0.89 % of the gross domestic product (GDP). Among this total, CNY990.3 billion (97.6 %) was attributed to premature death and CNY24.1 billion to disability; CNY822.3 billion (81.1 %) to males and CNY853.8 billion (84.2 %) to populations under the age of 60 years. Region heterogeneity was observed to be CNY26.5 billion for the Northwest and CNY263.7 billion for the East. Of the overall IEBC, 58.8 % (CNY596.9 billion) could be attributed to a range of modifiable risk factors (tobacco was the leading one at CNY304.6 billion); 76.0 % (CNY770.8 billion) was attributed to screening-targeted cancers, mainly gastrointestinal cancers (CNY458.2 billion), lung cancer (CNY232.9 billion), breast and cervical cancer (CNY57.2 billion). The by-cancer median value of the indirect-to-direct economic burden ratio was 2.56 (range 0.83–4.76).

Conclusions

The previously underestimated IEBC was roughly 3 times the reported direct economic burden in populations in China. Systematic quantification of the IEBC from "preventable" and "screenable" cancer types suggests there to be a potential extent of future economic benefit of implementing more effective and scaled-up population-based primary and secondary interventions.
目标:癌症带来了巨大的负担。在中国,对癌症经济负担的研究主要集中在直接经济负担上,而对癌症间接经济负担(IEBC)的研究被忽视。因此,我们的目标是在2021年对中国的IEBC进行系统量化。方法:采用人力资本方法对企业间创业行为进行评估。生产力时间损失是根据GBD 2021中的残疾调整生命年(DALYs)估算的。劳动力参与率和人均经济参数来源于各种数据集,并进行了亚组分析和敏感性分析。间接与直接经济负担率的估算部分基于文献综述的结果。结果:2021年中国人口总体IEBC预计为10144亿元,占国内生产总值(GDP)的0.89%。其中,9903亿元(97.6%)归因于过早死亡,241亿元归因于残疾;男性8223亿元(81.1%),60岁以下8538亿元(84.2%)。区域异质性为西北265亿元,东部2637亿元。在总体的IEBC中,58.8%(5969亿元)可归因于一系列可改变的风险因素(烟草是主要风险,为3046亿元);76.0%(7708亿元)用于筛查靶向癌症,主要是胃肠道癌症(4582亿元)、肺癌(2329亿元)、乳腺癌和宫颈癌(572亿元)。不同癌症的间接-直接经济负担率中位数为2.56(范围0.83 ~ 4.76)。结论:以前被低估的IEBC大约是中国人口直接经济负担的3倍。对“可预防”和“可筛查”癌症类型的IEBC进行系统量化表明,实施更有效和规模更大的以人群为基础的初级和二级干预措施,在未来可能产生一定程度的经济效益。
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引用次数: 0
Invisible geographies - the rural and coastal blind spot in UK cancer policy: A content analysis 看不见的地理——英国癌症政策中的农村和沿海盲点:内容分析。
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-10-14 DOI: 10.1016/j.jcpo.2025.100650
David Nelson , Natalia Calanzani , Ben Pickwell-Smith , Katie Spencer , Samuel Cooke , Tanja K. Kleinhappel , Maxime Inghels , Kathie McPeake , Ros Kane , Shahana A. Naqvi , Eila Watson , Anna Prytherch , Rebecca Foster , Lynn Calman , Peter Selby , Mark Lawler , Peter Murchie

Background

The United Kingdom’s (UK) diverse geography means many people live in rural and coastal areas, where cancer outcomes are often poorer than in urban settings. Devolution means that the four nations of the UK have distinct approaches to cancer care. Scotland, Wales, and Northern Ireland have recently published national cancer strategies, while England’s new plan is expected later in 2025. This study examined UK cancer policy documents, to identify, how, and to what extent, rural or coastal issues were considered.

Methods

UK cancer policy documents from 2000 to 2024 were sourced via The International Cancer Control Partnership (ICCP) website (https://iccp-portal.org/), UK government sites and Google. Documents were searched for rural and coastal related terms.

Results

Fifty-five documents were included (England n = 17; Northern Ireland n = 10; Scotland n = 21; Wales n = 7). No recent policies included a specific section or explicit recommendations for rural or coastal cancer care. Across the policies, contextual analysis highlighted that terms to promote rural or coastal equity rarely appeared within recommendations. Northern Ireland gave more attention to rural issues than other nations, as evidenced by a rural needs impact assessment and supporting documents to inform Northern Ireland’s Cancer Strategy 2022–2032.

Conclusion

Despite sizeable rural and coastal populations facing specific health challenges across the UK, national cancer policies excepting Northern Ireland gave minimal guidance for delivering cancer care tailored to these communities. Other UK nations should consider adopting more rural-centric approaches like Northern Ireland.

Policy summary

Coastal and rural health issues have received policy attention via the Chief Medical Officer for England’s annual reports (2021; 2023) and more recently in the UK Government’s 10 Year Health Plan for England (July 2025). However, when it comes to high-level cancer policy across the UK, the needs of rural and coastal people with cancer are not being adequately or specifically recognised.
背景:英国(UK)多样化的地理环境意味着许多人生活在农村和沿海地区,那里的癌症预后往往比城市环境差。权力下放意味着英国的四个国家有不同的癌症治疗方法。苏格兰、威尔士和北爱尔兰最近公布了国家癌症战略,而英格兰的新计划预计将在2025年晚些时候出台。这项研究检查了英国的癌症政策文件,以确定如何以及在多大程度上考虑了农村或沿海问题。方法:从国际癌症控制伙伴关系(ICCP)网站(https://iccp-portal.org/)、英国政府网站和谷歌获取2000-2024年英国癌症政策文件。对文件进行了农村和沿海相关术语的搜索。结果:共纳入文献55篇(英格兰17篇;北爱尔兰10篇;苏格兰21篇;威尔士7篇)。最近的政策中没有针对农村或沿海地区癌症治疗的专门章节或明确建议。在所有政策中,背景分析强调,促进农村或沿海公平的术语很少出现在建议中。北爱尔兰比其他国家更关注农村问题,为北爱尔兰《2022-2032年癌症战略》提供信息的农村需求影响评估和支持性文件证明了这一点。结论:尽管英国各地有大量农村和沿海人口面临特定的健康挑战,但除了北爱尔兰以外,国家癌症政策对为这些社区提供量身定制的癌症护理提供了最低限度的指导。其他英国国家应该考虑采取像北爱尔兰那样以农村为中心的方法。政策摘要:通过英格兰首席医疗官的年度报告(2021年和2023年)以及最近的联合王国政府的《英格兰10年健康计划》(2025年7月),沿海和农村健康问题得到了政策关注。然而,当涉及到英国高水平的癌症政策时,农村和沿海地区癌症患者的需求没有得到充分或特别的认识。
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引用次数: 0
Longitudinal validation of the PROFFIT questionnaire to assess financial toxicity in cancer patients profit问卷评估癌症患者财务毒性的纵向验证。
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-10-04 DOI: 10.1016/j.jcpo.2025.100645
L. Arenare , C. Porta , D. Barberio , S. Terzolo , V. Zagonel , S. Pisconti , L. Del Mastro , C. Pinto , D. Bilancia , S. Cinieri , M. Rizzo , G. Migliaccio , V. Montesarchio , L. Del Campo , F. De Lorenzo , E. Iannellil , L. Gitto , C.M. Vaccaro , L. Frontini , D. Giannarelli , F. Perrone

Background

Financial toxicity (FT) is a growing issue for cancer patients worldwide. The PROFFIT questionnaire was developed in Italy to measure FT and identify its determinants in cancer patients within a public health system.

Methods

A prospective study was conducted with 221 cancer patients from 10 Italian centres between March 2021 and July 2022 to validate the PROFFIT questionnaire in patients undergoing active treatment. The PROFFIT and EORTC-QLQ-C30 questionnaires were administered. Statistical analyses were performed on the PROFFIT-score (items 1–7), the financial difficulties item (Q28), and the global health status/quality of life (HR-QOL) scale from the EORTC-QLQ-C30. Geographic disparities were also analysed.

Results

A total of 1149 questionnaires were completed (83 % paper-based, 17 % electronically). The median observation period was 5 months (IQR 4.5–5.8). Missing phenomenon increased over time but was not affected by the baseline PROFFIT-score. PROFFIT-score remained stable throughout treatment, with patients in Southern Italy reporting higher (worse) values. Significant associations (p < 0.0001) were found between PROFFIT-score and Q28 at all time-points. Moderate inverse correlations were observed between PROFFIT-score and HR-QOL.

Conclusions

PROFFIT shows strong longitudinal validity for assessing FT in cancer patients. PROFFIT-score does not significantly change during treatment, but regional disparities highlight the need for targeted interventions, particularly in underserved areas. Further research will define cut-off values and explore FT dynamics across different patient populations.

Policy Summary

PROFFIT validation analyses make the instrument suitable to measure FT in cancer patients within public health systems. In addition, it may represent a valuable tool to plan specific local health policies being sensible to macro-regional variability. Finally, on the long run, it might be useful to test the impact of policies implemented against FT.
背景:金融毒性(FT)是全球癌症患者日益关注的问题。PROFFIT问卷是在意大利开发的,用于测量FT并确定公共卫生系统中癌症患者的决定因素。方法:在2021年3月至2022年7月期间,对来自意大利10个中心的221名癌症患者进行了一项前瞻性研究,以验证PROFFIT问卷在接受积极治疗的患者中的有效性。采用profit问卷和EORTC-QLQ-C30问卷。对proffit评分(项目1-7)、财务困难项目(Q28)和EORTC-QLQ-C30的整体健康状况/生活质量(HR-QOL)量表进行统计分析。还分析了地理差异。结果:共完成问卷1149份,其中纸质问卷83%,电子问卷17%。中位观察期为5个月(IQR 4.5 ~ 5.8)。缺失现象随着时间的推移而增加,但不受基线profit -score的影响。在整个治疗过程中,profit -评分保持稳定,意大利南部的患者报告更高(更差)的值。结论:PROFFIT在评估癌症患者的FT方面具有很强的纵向有效性。profit -score在治疗期间没有显著变化,但地区差异突出了有针对性干预的必要性,特别是在服务不足的地区。进一步的研究将定义临界值,并探索不同患者群体的FT动态。政策摘要:profit验证分析使该工具适用于在公共卫生系统中测量癌症患者的FT。此外,它可能是规划适合宏观区域变化的具体地方卫生政策的宝贵工具。最后,从长期来看,测试针对金融危机实施的政策的影响可能是有用的。
{"title":"Longitudinal validation of the PROFFIT questionnaire to assess financial toxicity in cancer patients","authors":"L. Arenare ,&nbsp;C. Porta ,&nbsp;D. Barberio ,&nbsp;S. Terzolo ,&nbsp;V. Zagonel ,&nbsp;S. Pisconti ,&nbsp;L. Del Mastro ,&nbsp;C. Pinto ,&nbsp;D. Bilancia ,&nbsp;S. Cinieri ,&nbsp;M. Rizzo ,&nbsp;G. Migliaccio ,&nbsp;V. Montesarchio ,&nbsp;L. Del Campo ,&nbsp;F. De Lorenzo ,&nbsp;E. Iannellil ,&nbsp;L. Gitto ,&nbsp;C.M. Vaccaro ,&nbsp;L. Frontini ,&nbsp;D. Giannarelli ,&nbsp;F. Perrone","doi":"10.1016/j.jcpo.2025.100645","DOIUrl":"10.1016/j.jcpo.2025.100645","url":null,"abstract":"<div><h3>Background</h3><div>Financial toxicity (FT) is a growing issue for cancer patients worldwide. The PROFFIT questionnaire was developed in Italy to measure FT and identify its determinants in cancer patients within a public health system.</div></div><div><h3>Methods</h3><div>A prospective study was conducted with 221 cancer patients from 10 Italian centres between March 2021 and July 2022 to validate the PROFFIT questionnaire in patients undergoing active treatment. The PROFFIT and EORTC-QLQ-C30 questionnaires were administered. Statistical analyses were performed on the PROFFIT-score (items 1–7), the financial difficulties item (Q28), and the global health status/quality of life (HR-QOL) scale from the EORTC-QLQ-C30. Geographic disparities were also analysed.</div></div><div><h3>Results</h3><div>A total of 1149 questionnaires were completed (83 % paper-based, 17 % electronically). The median observation period was 5 months (IQR 4.5–5.8). Missing phenomenon increased over time but was not affected by the baseline PROFFIT-score. PROFFIT-score remained stable throughout treatment, with patients in Southern Italy reporting higher (worse) values. Significant associations (p &lt; 0.0001) were found between PROFFIT-score and Q28 at all time-points. Moderate inverse correlations were observed between PROFFIT-score and HR-QOL.</div></div><div><h3>Conclusions</h3><div>PROFFIT shows strong longitudinal validity for assessing FT in cancer patients. PROFFIT-score does not significantly change during treatment, but regional disparities highlight the need for targeted interventions, particularly in underserved areas. Further research will define cut-off values and explore FT dynamics across different patient populations.</div></div><div><h3>Policy Summary</h3><div>PROFFIT validation analyses make the instrument suitable to measure FT in cancer patients within public health systems. In addition, it may represent a valuable tool to plan specific local health policies being sensible to macro-regional variability. Finally, on the long run, it might be useful to test the impact of policies implemented against FT.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"46 ","pages":"Article 100645"},"PeriodicalIF":2.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seizing the opportunity to leverage home-based palliative care for cancer education and screening in high-burden and resource-limited settings in India 抓住机会,在印度高负担和资源有限的环境中利用家庭姑息治疗进行癌症教育和筛查。
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-10-03 DOI: 10.1016/j.jcpo.2025.100646
Laxman Kumar Mahaseth , Subhadra Goala , Vidhubala Elangovan , Kathirvel Soundappan , Krishnakumar Rathnam , Bibha Thapa , Kanan Singha , Ravi Kannan

Background

Despite national screening efforts and a high cancer burden, the cancer screening rate is low in the northeast region of India. Seizing every opportunity for early detection is crucial in reducing cancer-related morbidity and mortality. This study assessed the outcomes of cancer education and symptom screening (CESS) among family members and neighbours of cancer patients on home-based palliative care (Home-PC) in Barak Valley of Assam, India.

Methods

This is a retrospective cohort study based on record review. Trained lay health workers (TLHW) attached to a tertiary cancer hospital conducted CESS sessions (self-administered or facilitated questionnaire) during routine Home-PC visits.

Results

Of 916 individuals, 75 (8.2 %) reported cancer-related symptoms and 33 (44 %) attended the screening OPD of a tertiary hospital for assessment. Of them, 17 (51.5 %) were diagnosed with cancer, predominantly oral, breast, and other cancers. The median (interquartile range) days from symptom screening to screening OPD visit was 10 (2.5, 49.5) days, while from screening OPD visit to diagnosis was 1 (0, 8) day.

Conclusion

Integrating CESS into Home-PC is feasible and aids in prompt diagnosis in resource-limited settings. This strategy could be used as an opportunity for early cancer detection and management, especially in high-burden regions like Northeast India.
背景:尽管国家努力筛查和高癌症负担,癌症筛查率在印度东北部地区很低。抓住每一个早期发现的机会对于降低癌症相关发病率和死亡率至关重要。本研究评估了印度阿萨姆邦巴拉克山谷癌症患者家庭成员和邻居对家庭姑息治疗(Home-PC)的癌症教育和症状筛查(CESS)的结果。方法:这是一项基于文献回顾的回顾性队列研究。附属于三级癌症医院的训练有素的非专业保健工作者(TLHW)在常规家庭个人电脑访问期间进行了CESS会议(自我管理或辅助问卷调查)。结果:在916名患者中,75名(8.2%)报告了癌症相关症状,33名(44%)参加了三级医院的门诊筛查评估。其中17人(51.5%)被诊断患有癌症,主要是口腔癌、乳腺癌和其他癌症。从症状筛查到筛查门诊就诊的中位数(四分位数间距)为10(2.5,49.5)天,而从筛查门诊就诊到诊断为1(0,8)天。结论:在资源有限的情况下,将CESS纳入家庭pc是可行的,有助于及时诊断。这一策略可以作为早期癌症检测和管理的机会,特别是在印度东北部等高负担地区。
{"title":"Seizing the opportunity to leverage home-based palliative care for cancer education and screening in high-burden and resource-limited settings in India","authors":"Laxman Kumar Mahaseth ,&nbsp;Subhadra Goala ,&nbsp;Vidhubala Elangovan ,&nbsp;Kathirvel Soundappan ,&nbsp;Krishnakumar Rathnam ,&nbsp;Bibha Thapa ,&nbsp;Kanan Singha ,&nbsp;Ravi Kannan","doi":"10.1016/j.jcpo.2025.100646","DOIUrl":"10.1016/j.jcpo.2025.100646","url":null,"abstract":"<div><h3>Background</h3><div>Despite national screening efforts and a high cancer burden, the cancer screening rate is low in the northeast region of India. Seizing every opportunity for early detection is crucial in reducing cancer-related morbidity and mortality. This study assessed the outcomes of cancer education and symptom screening (CESS) among family members and neighbours of cancer patients on home-based palliative care (Home-PC) in Barak Valley of Assam, India.</div></div><div><h3>Methods</h3><div>This is a retrospective cohort study based on record review. Trained lay health workers (TLHW) attached to a tertiary cancer hospital conducted CESS sessions (self-administered or facilitated questionnaire) during routine Home-PC visits.</div></div><div><h3>Results</h3><div>Of 916 individuals, 75 (8.2 %) reported cancer-related symptoms and 33 (44 %) attended the screening OPD of a tertiary hospital for assessment. Of them, 17 (51.5 %) were diagnosed with cancer, predominantly oral, breast, and other cancers. The median (interquartile range) days from symptom screening to screening OPD visit was 10 (2.5, 49.5) days, while from screening OPD visit to diagnosis was 1 (0, 8) day.</div></div><div><h3>Conclusion</h3><div>Integrating CESS into Home-PC is feasible and aids in prompt diagnosis in resource-limited settings. This strategy could be used as an opportunity for early cancer detection and management, especially in high-burden regions like Northeast India.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"46 ","pages":"Article 100646"},"PeriodicalIF":2.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to rethink diffusion modality of preliminary results from industry-sponsored clinical trials in oncology: Considerations from the Italian Network of Cancer Patients (ROPI). 是时候重新思考行业资助的肿瘤学临床试验初步结果的扩散模式了:来自意大利癌症患者网络(ROPI)的考虑。
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-09-25 DOI: 10.1016/j.jcpo.2025.100644
Stefania Gori
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引用次数: 0
Promoting a research agenda for cancer treatment for intravenous devices with clinicians in Europe; the PRACTICE survey 与欧洲临床医生一起推动静脉注射装置治疗癌症的研究议程;PRACTICE调查。
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-09-22 DOI: 10.1016/j.jcpo.2025.100643
Caitriona Duggan , Orlaith Hernon , Andrew J. Simpkin , Viktor Manasek , Julio C. de la Torre-Montero , Paulo Santos-Costa , Jonathan G. Moss , Christina H. Ruhlmann , Knut Taxbro , Miguel Angel Rodriguez- Calero , Rodrigo Oom , Rita Barroca , Onagh O. Grady , Jacqueline Daly , Ian Blanco-Mavillard , Nikolina Dodlek , Jiri Charvát , Saloa Unanue-Arza , Bibiana Krakovska , Peter J. Carr

Aims

The PRACTICE survey aimed to characterize vascular access device (VAD) practices for systemic anti-cancer therapy (SACT) across Europe, addressing gaps in clinician decision-making, training, and complication management.

Methods

Conducted as a cross-sectional survey from May to October 2024, the study engaged healthcare professionals (HCPs) from 18 European countries, with 403 completing demographic questions and 166 responding to procedural and training-related queries.

Results

Results revealed significant variability in VAD selection, influenced by institutional protocols, geographic location, and the presence of vascular access teams (VATs). Oncologists were identified as primary decision-makers (36 %), though nursing staff played a pivotal role in daily management. Peripheral intravenous catheters (PIVCs) dominated in Ireland and Finland (43–49 %), while tunnelled implantable devices (TIVADs) were preferred in Belgium (65 %). Barriers to optimal VAD selection included insufficient training (80 % sought further education) and inconsistent guideline adoption (51 % reported institutional protocols).

Conclusion

The study underscores the need for standardised practices, interdisciplinary collaboration, and enhanced training. Findings highlight opportunities for integrating VAD selection into cancer care certification metrics and fostering partnerships between oncology and vascular access societies.
目的:PRACTICE调查旨在描述整个欧洲用于全身抗癌治疗(SACT)的血管通路装置(VAD)实践,解决临床医生决策、培训和并发症管理方面的差距。方法:采用横断面调查的方法,于2024年5月至10月对来自18个欧洲国家的卫生保健专业人员(HCPs)进行了研究,其中403人完成了人口统计问题,166人回答了程序和培训相关问题。结果:结果显示,VAD的选择存在显著差异,受机构协议、地理位置和血管通路小组(VATs)存在的影响。肿瘤学家被确定为主要决策者(36%),尽管护理人员在日常管理中发挥了关键作用。外周静脉导管(pivc)在爱尔兰和芬兰占主导地位(43-49%),而隧道植入装置(tivad)在比利时更受欢迎(65%)。选择最佳VAD的障碍包括培训不足(80%的人寻求继续教育)和指南采用不一致(51%的人报告了机构协议)。结论:该研究强调了标准化实践、跨学科合作和加强培训的必要性。研究结果强调了将VAD选择纳入癌症护理认证指标以及促进肿瘤和血管准入协会之间合作的机会。
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引用次数: 0
Exploring experiences of reasonable adjustments in cancer care among patients with disabilities and their carers: A focus group study in South West England 残障患者及其照护者在癌症照护中合理调整的经验探讨:英格兰西南部的焦点小组研究。
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-09-18 DOI: 10.1016/j.jcpo.2025.100641
Selin Siviş , Andrew Turner , Hannah Little , Shamim Kholwadia , Ruth Hendy , Fiona Spence , Gifty Markey , Jon Banks

Background

The UK Equality Act 2010 mandates equal access to healthcare for people with disabilities. For those with disabilities who have also been diagnosed with cancer, addressing these needs is complex and multifaceted. Whilst existing research has primarily focused on reasonable adjustments for individuals with learning disabilities or autism, this study broadens the scope to include physical disabilities, cognitive or sensory impairments, and mental health conditions.

Aim

This study aimed qualitatively explore and understand the experiences of individuals with disabilities requiring reasonable adjustments, who have direct or indirect exposure to cancer treatment within the cancer care setting, as well as the experiences of their carers.

Methods

Qualitative study based on seven focus groups with 44 participants who have direct or indirect experience of cancer treatment and experience of one or more of a range of conditions that may require reasonable adjustments. Thematic analysis was used inductively to explore patterns.

Results

Participants described various care pathway adjustments but also noted their limited effectiveness. The main concern was a lack of alignment with individual needs. Three key areas for improvement emerged: (1) communication and coordination (e.g., clearer signposting, longer appointments, better understanding of needs); (2) support for family and carers (e.g., tailored adjustments for caregivers, clearer explanations); and (3) adherence to compassion and empathy (e.g., avoiding jargon, using accessible language, and ensuring patients feel heard).

Conclusion

Reasonable adjustments are necessary but not sufficient for equitable care. Participants emphasised the need for an integrated approach to individual needs to ensure adjustments are both accessible and effective.

Policy summary

An integrated understanding of individuals’ and their family carers’ needs should underpin approaches to reasonable adjustments by healthcare providers. A first step to achieving this is to develop training for healthcare professionals to encompass a broader understanding of reasonable adjustments beyond legal categories.
背景:2010年《联合王国平等法》规定残疾人享有平等的医疗保健机会。对于那些同时被诊断患有癌症的残疾人来说,解决这些需求是复杂和多方面的。虽然现有的研究主要集中在对有学习障碍或自闭症的个体进行合理调整,但这项研究扩大了范围,包括身体残疾、认知或感觉障碍以及精神健康状况。目的:本研究旨在定性地探索和了解在癌症护理环境中直接或间接接受癌症治疗的需要合理调整的残疾个体的经历,以及他们的照顾者的经历。方法:定性研究基于7个焦点小组的44名参与者,他们有直接或间接的癌症治疗经验,并经历了一种或多种可能需要合理调整的条件。主题分析采用归纳分析的方法来探索模式。结果:参与者描述了各种护理路径调整,但也注意到其有限的有效性。主要的担忧是缺乏与个人需求的一致性。出现了三个需要改进的关键领域:(1)沟通和协调(例如,更清楚的指示、更长的预约、更好地了解需要);(2)对家庭和照顾者的支持(例如,为照顾者量身定制调整,更清晰的解释);(3)坚持同情和同理心(例如,避免行话,使用通俗易懂的语言,并确保患者感到被倾听)。结论:合理的调整是必要的,但不足以实现公平护理。与会者强调需要对个人需求采取综合办法,以确保调整既容易获得又有效。政策总结:对个人及其家庭照顾者需求的综合理解应该是医疗保健提供者进行合理调整的基础。实现这一目标的第一步是为医疗保健专业人员开展培训,使其对法律类别之外的合理调整有更广泛的理解。
{"title":"Exploring experiences of reasonable adjustments in cancer care among patients with disabilities and their carers: A focus group study in South West England","authors":"Selin Siviş ,&nbsp;Andrew Turner ,&nbsp;Hannah Little ,&nbsp;Shamim Kholwadia ,&nbsp;Ruth Hendy ,&nbsp;Fiona Spence ,&nbsp;Gifty Markey ,&nbsp;Jon Banks","doi":"10.1016/j.jcpo.2025.100641","DOIUrl":"10.1016/j.jcpo.2025.100641","url":null,"abstract":"<div><h3>Background</h3><div>The UK Equality Act 2010 mandates equal access to healthcare for people with disabilities. For those with disabilities who have also been diagnosed with cancer, addressing these needs is complex and multifaceted. Whilst existing research has primarily focused on reasonable adjustments for individuals with learning disabilities or autism, this study broadens the scope to include physical disabilities, cognitive or sensory impairments, and mental health conditions.</div></div><div><h3>Aim</h3><div>This study aimed qualitatively explore and understand the experiences of individuals with disabilities requiring reasonable adjustments, who have direct or indirect exposure to cancer treatment within the cancer care setting, as well as the experiences of their carers.</div></div><div><h3>Methods</h3><div>Qualitative study based on seven focus groups with 44 participants who have direct or indirect experience of cancer treatment and experience of one or more of a range of conditions that may require reasonable adjustments. Thematic analysis was used inductively to explore patterns.</div></div><div><h3>Results</h3><div>Participants described various care pathway adjustments but also noted their limited effectiveness. The main concern was a lack of alignment with individual needs. Three key areas for improvement emerged: (1) communication and coordination (e.g., clearer signposting, longer appointments, better understanding of needs); (2) support for family and carers (e.g., tailored adjustments for caregivers, clearer explanations); and (3) adherence to compassion and empathy (e.g., avoiding jargon, using accessible language, and ensuring patients feel heard).</div></div><div><h3>Conclusion</h3><div>Reasonable adjustments are necessary but not sufficient for equitable care. Participants emphasised the need for an integrated approach to individual needs to ensure adjustments are both accessible and effective.</div></div><div><h3>Policy summary</h3><div>An integrated understanding of individuals’ and their family carers’ needs should underpin approaches to reasonable adjustments by healthcare providers. A first step to achieving this is to develop training for healthcare professionals to encompass a broader understanding of reasonable adjustments beyond legal categories.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"46 ","pages":"Article 100641"},"PeriodicalIF":2.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of the cost-effectiveness of HPV (self-sampling and health care provider sampling) versus VIA for cervical cancer screening in India 印度宫颈癌筛查HPV(自我抽样和卫生保健提供者抽样)与VIA的成本效益比较
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-09-18 DOI: 10.1016/j.jcpo.2025.100642
Apourv Pant, Gowthaman Thangavel, Stany Mathew, Anita Nath
Cervical cancer ranks as the fourth most common cancer in women globally and the second most prevalent in India. Preventive measures, such as HPV vaccination and various screening methods, are essential. Despite these strategies, the economic burden of cervical cancer remains significant due to its long-term nature and treatment costs. This study evaluates the cost-effectiveness of three screening approaches—VIA, HPV physician sampling, and HPV self-sampling—for women aged 30–65. A Markov-based cost-utility analysis with a lifetime horizon and one-year cycle length was conducted. Model parameters were sourced from peer-reviewed literature, national cancer registries, and health economic studies. Deterministic and probabilistic sensitivity analyses were performed to ensure the robustness of the results. Health Provider HPV sampling yielded the highest Quality-Adjusted Life Years (QALYs) at 5.97 (three years) and 4.28 (five years), compared to VIA’s 4.01 (three years) and 2.9 (five years), and HPV self-sampling’s 4.71 (three years) and 3.41 (five years). Over 30 cycles for 100,000 women, healthcare provider sampling achieved a maximum QALY gain of 13.40. Compared to other methods, it offered a gain of 2.94 QALYs at an incremental cost of 19,409 INR. While VIA screening is cost-saving, it provides reduced health benefits. HPV healthcare provider sampling is more cost-effective in terms of QALYs gained despite higher screening costs. A policy analysis is necessary to achieve 70 % cervical cancer screening coverage in India, focusing on current HPV screening strategies and identifying areas for improvement.
子宫颈癌是全球第四大最常见的女性癌症,在印度排名第二。预防措施,如HPV疫苗接种和各种筛查方法是必不可少的。尽管有这些策略,子宫颈癌的经济负担仍然很大,因为它的长期性和治疗费用。本研究评估了三种筛查方法的成本效益- via, HPV医生抽样和HPV自我抽样-用于30至65岁的女性。基于马尔可夫的成本-效用分析包括生命周期和一年的周期长度。模型参数来源于同行评议文献、国家癌症登记处和卫生经济学研究。进行确定性和概率敏感性分析,以确保结果的稳健性。健康提供者HPV抽样产生的最高质量调整生命年(QALYs)为5.97(3年)和4.28(5年),而VIA为4.01(3年)和2.9(5年),HPV自抽样为4.71(3年)和3.41(5年)。在超过30个周期的10万名妇女中,医疗保健提供者抽样实现了13.40的最大质量aly增益。与其他方法相比,它提供了2.94个QALYs的增益,增量成本为19,409印度卢比。虽然VIA筛查节省了成本,但它提供的健康益处却减少了。尽管筛查成本较高,但HPV医疗保健提供者抽样在获得质量aly方面更具成本效益。为了在印度实现70%的宫颈癌筛查覆盖率,有必要进行政策分析,重点关注当前的HPV筛查战略并确定需要改进的领域。
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引用次数: 0
Psycho-oncology in India 印度的精神肿瘤学。
IF 2 Q3 HEALTH POLICY & SERVICES Pub Date : 2025-09-16 DOI: 10.1016/j.jcpo.2025.100640
J. Deodhar , P. Nayak , C.S. Pramesh , A. Purushotham
Psychosocial care is essential for high-quality cancer care. Psycho-oncology is a developing discipline globally. A narrative review was conducted of studies published in India from 2000 to 2024 on psychosocial care in patients with cancer. Of 233 papers identified, 85 were included. Distress rates ranged from 22 % to 62 % with the highest being in head and neck and breast cancer. Seven tools for measuring distress have been validated in a few Indian languages. Cancer-related communication revealed high rates of collusion and use of euphemisms. There is a paucity of intervention studies. Few studies described psychosocial issues in children and adolescents and older adults.Therefore, future high-quality intervention and outcome studies are required. There is an urgent need for the inclusion of psycho-oncology in national cancer control policy globally.
心理社会护理对于高质量的癌症护理至关重要。精神肿瘤学是一门全球性的新兴学科。对2000年至2024年在印度发表的关于癌症患者心理社会护理的研究进行了叙述性回顾。在233篇论文中,85篇被收录。焦虑率从22-62%不等,其中头颈癌和乳腺癌的比例最高。七种测量痛苦的工具已经在一些印度语言中得到了验证。与癌症相关的交流表明,相互勾结和使用委婉语的比例很高。干预研究很少。很少有研究描述儿童、青少年和老年人的社会心理问题。因此,未来需要进行高质量的干预和结果研究。迫切需要将精神肿瘤学纳入全球国家癌症控制政策。
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引用次数: 0
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Journal of Cancer Policy
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