Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384084
Xiao Bing Chen, H. Lee, V. Chong, D. Wang
Partial Inferior turbinectomy is typically performed for patients suffering from chronic nasal obstruction due to hypertrophy of inferior turbinates and are refractory to other more conservative treatments In this paper, the effects of the various manner of incision performed on the inferior turbinates in terms of the resulting nasal air flow pattern were analyzed using computational fluid dynamics (CFD). The three 3D nasal models with partial inferior turbinectomy were reconstructed from the MRI scans of a healthy human subject by simulating the three remaining shapes of inferior turbinate after the respective turbinate surgery with the use of the software MIMICS 12.1. Thereafter high resolution 3D volume meshes comprising boundary layer effects and computational domain exterior to the nose were constructed. Numerical simulations were carried out using FLUENTS for CFD simulations. The Reynolds averaged Navier-Stokes equations were solved for the turbulence flow with SST k - ω model. The consequences of the various types of turbinate surgery were compared with the originally healthy nasal model as well as the nasal model with severe nasal obstruction. The velocity streamlines, the total pressure drop through the nasal cavity, and the local wall shear stress distribution were presented. The existence of small vortices, relatively larger local velocity and wall shear stress showed that turbinate surgery should be carefully planned as it may affect normal local nasal functions.
下鼻甲部分切除术是由于下鼻甲肥大引起的慢性鼻塞患者的典型手术，其他保守的治疗方法难以治疗。本文利用计算流体动力学(CFD)分析了不同切口方式对下鼻甲鼻腔气流模式的影响。通过使用MIMICS 12.1软件模拟下鼻甲手术后剩余的三种形状，根据健康受试者的MRI扫描重建三个部分切除下鼻甲的3D鼻模型。在此基础上，构建了包含边界层效应和鼻鼻外计算域的高分辨率三维体网格。采用FLUENTS进行数值模拟。用SST k - ω模型求解了湍流流场的Reynolds平均Navier-Stokes方程。将不同鼻甲手术方式与原健康鼻模型及重度鼻塞鼻模型进行比较。给出了速度流线、通过鼻腔的总压降和局部壁面剪应力分布。小漩涡的存在，相对较大的局部速度和壁剪切应力表明鼻甲手术应仔细计划，因为它可能影响正常的局部鼻功能。
{"title":"Numerical simulation for nasal flow with partial inferior turbinatomy-a turbulent model","authors":"Xiao Bing Chen, H. Lee, V. Chong, D. Wang","doi":"10.1109/ICBPE.2009.5384084","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384084","url":null,"abstract":"Partial Inferior turbinectomy is typically performed for patients suffering from chronic nasal obstruction due to hypertrophy of inferior turbinates and are refractory to other more conservative treatments In this paper, the effects of the various manner of incision performed on the inferior turbinates in terms of the resulting nasal air flow pattern were analyzed using computational fluid dynamics (CFD). The three 3D nasal models with partial inferior turbinectomy were reconstructed from the MRI scans of a healthy human subject by simulating the three remaining shapes of inferior turbinate after the respective turbinate surgery with the use of the software MIMICS 12.1. Thereafter high resolution 3D volume meshes comprising boundary layer effects and computational domain exterior to the nose were constructed. Numerical simulations were carried out using FLUENTS for CFD simulations. The Reynolds averaged Navier-Stokes equations were solved for the turbulence flow with SST k - ω model. The consequences of the various types of turbinate surgery were compared with the originally healthy nasal model as well as the nasal model with severe nasal obstruction. The velocity streamlines, the total pressure drop through the nasal cavity, and the local wall shear stress distribution were presented. The existence of small vortices, relatively larger local velocity and wall shear stress showed that turbinate surgery should be carefully planned as it may affect normal local nasal functions.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125304963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384064
P. Y. Li, P. Lai, C. Lin
Drug resistance is a frequent clinical problem that seriously reduces the efficacy of many chemotherapy agents. In this study, the effect of micellar encapsulation using poly(L-lactide)-vitamin E TPGS (PLA-TPGS) copolymer on intracellular distribution of doxorubicin was studied in vitro. As our results, doxorubicin can be encapsulated successfully into PLA-TPGS formed micelle with a uniform particle size (≪ 200nm) that could exhibit the passive targeting ability to cancer tissue. Moreover, the nuclear accumulation of doxorubicin can be improved significantly in micelle form that can utilize as a potential carrier to overcome doxorubicin-resistance in breast MCF-7 cancer cells.
{"title":"Reversal of multidrug resistance using poly(L-lactide)-vitamin E TPGS micelles in breast cancer cell","authors":"P. Y. Li, P. Lai, C. Lin","doi":"10.1109/ICBPE.2009.5384064","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384064","url":null,"abstract":"Drug resistance is a frequent clinical problem that seriously reduces the efficacy of many chemotherapy agents. In this study, the effect of micellar encapsulation using poly(L-lactide)-vitamin E TPGS (PLA-TPGS) copolymer on intracellular distribution of doxorubicin was studied in vitro. As our results, doxorubicin can be encapsulated successfully into PLA-TPGS formed micelle with a uniform particle size (≪ 200nm) that could exhibit the passive targeting ability to cancer tissue. Moreover, the nuclear accumulation of doxorubicin can be improved significantly in micelle form that can utilize as a potential carrier to overcome doxorubicin-resistance in breast MCF-7 cancer cells.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125280143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384060
Wendan Xie, Weijia Kong, Enmin Song, Qiang Zhang
This paper presents a virtual reality system that allows a user to learn accurately mimic 3D temporal bone and ear anatomy. The computer-based system simulator is helpful to medical students in identifying the anatomic structures on the view of the auditory system. The surgical training system simulator can be effectively used to anatomic training and teaching at all levels of education.
{"title":"A surgical training simulator for temporal bone anatomy education","authors":"Wendan Xie, Weijia Kong, Enmin Song, Qiang Zhang","doi":"10.1109/ICBPE.2009.5384060","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384060","url":null,"abstract":"This paper presents a virtual reality system that allows a user to learn accurately mimic 3D temporal bone and ear anatomy. The computer-based system simulator is helpful to medical students in identifying the anatomic structures on the view of the auditory system. The surgical training system simulator can be effectively used to anatomic training and teaching at all levels of education.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115053458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384081
S. Ravichandran, B.Y.X. Dan, Lim Wan Yi, Tan Kee Kwoon, Then Tze Kang, Siti Faradina Bte Isa, S. Kumar
The scope of the paper is to investigate the design of an ultraviolet sterilization unit developed to work in conjunction with a fluid dispenser for dispensing fluids in measured quantities periodically. Common problems associated with contamination of fluids in these dispensers have been carefully investigated to qualitatively document the requirements of the system. We have designed a protocol to study the efficiency of the system and in order to have a real picture of the antimicrobial effects of ultraviolet radiation at various locations inside the dispensing chamber. To implement this protocol, we have designed an implantable array which is capable of containing micro organisms in Petri dishes which can be stationed at various levels within the stainless steel dispenser. Studies on the microbial growth conducted periodically under the influence of ultraviolet radiation of known intensity provide a qualitative picture on the antimicrobial effects of ultraviolet rays at various depths. Thus it was possible to qualitatively analyze each sample for documenting antimicrobial effect. The study has been focused on the qualitative assessment of the antimicrobial effects at various parts of the dispenser and also the variations of the antimicrobial effects at various depths of the fluid contained in the dispenser. This study provides a good understanding on the intensity of the ultraviolet radiation required for providing a perfect antimicrobial environment and also other factors that are critical in the design of the system as a whole for dispensing fluids used in biological applications.
{"title":"Advances in the development of ultraviolet sterilization system for specific biological applications","authors":"S. Ravichandran, B.Y.X. Dan, Lim Wan Yi, Tan Kee Kwoon, Then Tze Kang, Siti Faradina Bte Isa, S. Kumar","doi":"10.1109/ICBPE.2009.5384081","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384081","url":null,"abstract":"The scope of the paper is to investigate the design of an ultraviolet sterilization unit developed to work in conjunction with a fluid dispenser for dispensing fluids in measured quantities periodically. Common problems associated with contamination of fluids in these dispensers have been carefully investigated to qualitatively document the requirements of the system. We have designed a protocol to study the efficiency of the system and in order to have a real picture of the antimicrobial effects of ultraviolet radiation at various locations inside the dispensing chamber. To implement this protocol, we have designed an implantable array which is capable of containing micro organisms in Petri dishes which can be stationed at various levels within the stainless steel dispenser. Studies on the microbial growth conducted periodically under the influence of ultraviolet radiation of known intensity provide a qualitative picture on the antimicrobial effects of ultraviolet rays at various depths. Thus it was possible to qualitatively analyze each sample for documenting antimicrobial effect. The study has been focused on the qualitative assessment of the antimicrobial effects at various parts of the dispenser and also the variations of the antimicrobial effects at various depths of the fluid contained in the dispenser. This study provides a good understanding on the intensity of the ultraviolet radiation required for providing a perfect antimicrobial environment and also other factors that are critical in the design of the system as a whole for dispensing fluids used in biological applications.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126430355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384078
Seng Kok Yong, Loke Weng Keong, M. Shabbir, Jon Deoon Lee
Pyridostigmine is a reversible inhibitor of acetylcholinesterase (AChE). The objective of the present analysis was to characterise the population pharmacokinetics / pharmacodynamics (PK/PD) of pyridostigmine given as pyridostigmine bromide. Fifty healthy Chinese males received 7 doses of 30 mg of pyridostigmine bromide each every 8 hours orally. Plasma concentrations of pyridostigmine and red blood cell (RBC) AChE activity were determined at various times within 8 hours after the first and the seventh doses. The resulting PK data were fit to a single compartment open model with first order absorption and elimination. The PD was modelled using an inhibitory Emax model. The potential influence of demographic and biological covariates on the model parameters was investigated. Modelling was performed using NONMEM VI. The apparent clearance and volume of distribution as well as absorption rate constant of plasma pyridostigmine were estimated to be 136 L/hr, 130 L and 0.68 1/hr respectively. The maximum RBC AChE activity decrease (Emax) and plasma pyridostigmine concentration producing 50% of this reduction (EC50) were estimated to be 9.32 AChE units per gram haemoglobin and 51.9 ng/ml respectively. None of the tested covariates explained any additional variability in either PK or PD. Dosing simulations suggested that 30 mg repeated every 6 hours might be needed to achieve steady-state trough percentage inhibition above the recommended 10% in healthy Chinese male adults.
{"title":"Nonlinear mixed effects pharmacokinetic/pharmacodynamic analysis of the cholinesterase inhibitor pyridostigmine bromide in Chinese males","authors":"Seng Kok Yong, Loke Weng Keong, M. Shabbir, Jon Deoon Lee","doi":"10.1109/ICBPE.2009.5384078","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384078","url":null,"abstract":"Pyridostigmine is a reversible inhibitor of acetylcholinesterase (AChE). The objective of the present analysis was to characterise the population pharmacokinetics / pharmacodynamics (PK/PD) of pyridostigmine given as pyridostigmine bromide. Fifty healthy Chinese males received 7 doses of 30 mg of pyridostigmine bromide each every 8 hours orally. Plasma concentrations of pyridostigmine and red blood cell (RBC) AChE activity were determined at various times within 8 hours after the first and the seventh doses. The resulting PK data were fit to a single compartment open model with first order absorption and elimination. The PD was modelled using an inhibitory Emax model. The potential influence of demographic and biological covariates on the model parameters was investigated. Modelling was performed using NONMEM VI. The apparent clearance and volume of distribution as well as absorption rate constant of plasma pyridostigmine were estimated to be 136 L/hr, 130 L and 0.68 1/hr respectively. The maximum RBC AChE activity decrease (Emax) and plasma pyridostigmine concentration producing 50% of this reduction (EC50) were estimated to be 9.32 AChE units per gram haemoglobin and 51.9 ng/ml respectively. None of the tested covariates explained any additional variability in either PK or PD. Dosing simulations suggested that 30 mg repeated every 6 hours might be needed to achieve steady-state trough percentage inhibition above the recommended 10% in healthy Chinese male adults.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127108538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384070
M. Shieh, Y. Shieh, P. Lai
A specialized G-quadruplex DNA aptamer with nucleolin targeting ability, AS1411, has been studied for cancer therapy. In this study, we report a novel delivery strategy for chemo-photodynamic combined treatment using AS1411 aptamer conjugated with tetra-(N-methyl-4-pyridyl)-porphine by intercalation and outside binding. Our results show that the apt-TMP complex exhibited higher TMPyP4 accumulation in nucleolin over-expressing MCF-7 breast cancer cells than in M10 normal epithelium cells. After irradiation for 180 sec, the photodamage was apparently observed in MCF-7 cells. These results indicate that AS1411 aptamer can play as a potential photosensitizer carrier for for cancer therapy.
{"title":"AS1411 aptamer for targetable photosensitizer delivery","authors":"M. Shieh, Y. Shieh, P. Lai","doi":"10.1109/ICBPE.2009.5384070","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384070","url":null,"abstract":"A specialized G-quadruplex DNA aptamer with nucleolin targeting ability, AS1411, has been studied for cancer therapy. In this study, we report a novel delivery strategy for chemo-photodynamic combined treatment using AS1411 aptamer conjugated with tetra-(N-methyl-4-pyridyl)-porphine by intercalation and outside binding. Our results show that the apt-TMP complex exhibited higher TMPyP4 accumulation in nucleolin over-expressing MCF-7 breast cancer cells than in M10 normal epithelium cells. After irradiation for 180 sec, the photodamage was apparently observed in MCF-7 cells. These results indicate that AS1411 aptamer can play as a potential photosensitizer carrier for for cancer therapy.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133594390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384087
Jingran Wen, Xiaoyan Zhang, Ye Xu, Zuofeng Li, Lei Liu
Synchronous liver metastasis is one of the leading causes of the mortality in colorectal cancer patients. In this study, predictive models based on AdaBoost and logistic regression for detecting colorectal cancer patients with synchronous liver metastasis before operation were built and compared. Information gain method, genetic algorithm and AdaBoost were used for feature selection. The predictive performance of each model was evaluated with 10-fold cross-validation and the area under the receiver operating characteristic (ROC) curves. Four predictive variables were identified: CEA, CA50, tumor location (rectum) and maximum diameter. The influence of missing values was also evaluated and compared using serum biomarkers CEA and CA50. Our results indicate that AdaBoost performs better on data set with missing values, while logistic regression has better sensitivity. Both models could be used to develop a predictive model for colorectal cancer patients with synchronous liver metastasis.
{"title":"Comparison of AdaBoost and logistic regression for detecting colorectal cancer patients with synchronous liver metastasis","authors":"Jingran Wen, Xiaoyan Zhang, Ye Xu, Zuofeng Li, Lei Liu","doi":"10.1109/ICBPE.2009.5384087","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384087","url":null,"abstract":"Synchronous liver metastasis is one of the leading causes of the mortality in colorectal cancer patients. In this study, predictive models based on AdaBoost and logistic regression for detecting colorectal cancer patients with synchronous liver metastasis before operation were built and compared. Information gain method, genetic algorithm and AdaBoost were used for feature selection. The predictive performance of each model was evaluated with 10-fold cross-validation and the area under the receiver operating characteristic (ROC) curves. Four predictive variables were identified: CEA, CA50, tumor location (rectum) and maximum diameter. The influence of missing values was also evaluated and compared using serum biomarkers CEA and CA50. Our results indicate that AdaBoost performs better on data set with missing values, while logistic regression has better sensitivity. Both models could be used to develop a predictive model for colorectal cancer patients with synchronous liver metastasis.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132825513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384065
Charlie Nathanael Otto, S. D. Handoko, K. C. Keong
Key to adaptive immune response is the recognition of HLA/peptide complexes by a particular T-cell receptor, which obviously is preceded by HLA binding of the antigenic peptides. Extreme polymorphism of the HLA gene has claimed exhaustive revelation of the possible (TCR-)HLA/peptide interactions to be intractable should it be based on the wet-lab experiments alone. Sequence-based and structure-based predictors have since been developed to allow researchers perform the wet-lab experiments selectively on the potential candidates that have previously been predicted to elicit some immunogenic activities. Structure-based predictors, which often include the use of molecular simulations and the concept of association as well as dissociation energy, are generally unsuited for high-throughput screening despite ability of these predictors to generate more accurate prediction results. As the binding and recognition process occurs, new inter-atomic interactions are introduced—suggesting conformational changes are really anticipated. Nonetheless, only parts of the constituents shall experience structural changes. It is therefore desirable that all the substantial regions around which conformational changes are likely to happen be identified. The internal coordinates—i.e. the bond lengths, the bond angles, as well as the torsion angles—of the HLA-A*0201 were analyzed in this work before and after the binding and recognition process took place. The findings can hence be used as a guide to decide the flexibility of the molecules in the molecular simulations. For many of them, it is common to treat the whole receptor as rigid and the whole ligand as flexible since fully flexible receptor could incur huge computational cost. Semi-flexible receptor, therefore, could yield better accuracy yet maintain computational cost within reasonable limit.
{"title":"Identifying patterns of conformational changes in HLA-A*0201-related immunological activities","authors":"Charlie Nathanael Otto, S. D. Handoko, K. C. Keong","doi":"10.1109/ICBPE.2009.5384065","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384065","url":null,"abstract":"Key to adaptive immune response is the recognition of HLA/peptide complexes by a particular T-cell receptor, which obviously is preceded by HLA binding of the antigenic peptides. Extreme polymorphism of the HLA gene has claimed exhaustive revelation of the possible (TCR-)HLA/peptide interactions to be intractable should it be based on the wet-lab experiments alone. Sequence-based and structure-based predictors have since been developed to allow researchers perform the wet-lab experiments selectively on the potential candidates that have previously been predicted to elicit some immunogenic activities. Structure-based predictors, which often include the use of molecular simulations and the concept of association as well as dissociation energy, are generally unsuited for high-throughput screening despite ability of these predictors to generate more accurate prediction results. As the binding and recognition process occurs, new inter-atomic interactions are introduced—suggesting conformational changes are really anticipated. Nonetheless, only parts of the constituents shall experience structural changes. It is therefore desirable that all the substantial regions around which conformational changes are likely to happen be identified. The internal coordinates—i.e. the bond lengths, the bond angles, as well as the torsion angles—of the HLA-A*0201 were analyzed in this work before and after the binding and recognition process took place. The findings can hence be used as a guide to decide the flexibility of the molecules in the molecular simulations. For many of them, it is common to treat the whole receptor as rigid and the whole ligand as flexible since fully flexible receptor could incur huge computational cost. Semi-flexible receptor, therefore, could yield better accuracy yet maintain computational cost within reasonable limit.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132851405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384101
Ajay M. Cheriyan, Albert O. Jarvi, Z. Kalbarczyk, R. Iyer, K. Watkin
With the tremendous advancements in low cost, power efficient hardware and the recent interest in biomedical embedded systems, numerous traditional biomedical systems can be replaced with smaller embedded systems that do real-time analysis to provide bio-feedback to the users. This paper presents a prototype of an embedded system which is capable of real-time data collection, using analog and digital sensors and processing, to compute physiological variables and metrics. These metrics in turn can be used to determine information about the user's general well being. The sensors provide motion, brain wave activity (EEG) and blood oxygenation (SpO2) information. The system presented automatically computes the application specific metrics and indicates the results of the detection scheme to the user and to a monitoring base station. The metrics being used have been validated using raw data from patients suffering epileptic seizures and from past research. The paper also deals with application scenarios for such systems and architecture for an FPGA based implementation is discussed.
{"title":"Pervasive real-time biomedical monitoring system","authors":"Ajay M. Cheriyan, Albert O. Jarvi, Z. Kalbarczyk, R. Iyer, K. Watkin","doi":"10.1109/ICBPE.2009.5384101","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384101","url":null,"abstract":"With the tremendous advancements in low cost, power efficient hardware and the recent interest in biomedical embedded systems, numerous traditional biomedical systems can be replaced with smaller embedded systems that do real-time analysis to provide bio-feedback to the users. This paper presents a prototype of an embedded system which is capable of real-time data collection, using analog and digital sensors and processing, to compute physiological variables and metrics. These metrics in turn can be used to determine information about the user's general well being. The sensors provide motion, brain wave activity (EEG) and blood oxygenation (SpO2) information. The system presented automatically computes the application specific metrics and indicates the results of the detection scheme to the user and to a monitoring base station. The metrics being used have been validated using raw data from patients suffering epileptic seizures and from past research. The paper also deals with application scenarios for such systems and architecture for an FPGA based implementation is discussed.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129499875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384090
X.S. Teh, Y. Chng, W. Chong, T. Foo
Bone graft generation in vitro is limited by slow nutrient-waste exchange through thick scaffolds and insufficient mechanical stimuli required for induction and differentiation of osteoprogenitor cells, often requiring the use of suitable bioreactors to circumvent these limitations. In this study, we test the suitability of a modified rotary miniPERM™ bioreactor system in inducing proliferation and osteodifferentiation of human foetal mesenchymal stem cell (hfMSC) on poly-ε-caprolactone (PCL)-tricalcium phosphate (TCP) scaffolds.
{"title":"Use of a rotary bioreactor for growth and differentiation of mesenchymal stem cells","authors":"X.S. Teh, Y. Chng, W. Chong, T. Foo","doi":"10.1109/ICBPE.2009.5384090","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384090","url":null,"abstract":"Bone graft generation in vitro is limited by slow nutrient-waste exchange through thick scaffolds and insufficient mechanical stimuli required for induction and differentiation of osteoprogenitor cells, often requiring the use of suitable bioreactors to circumvent these limitations. In this study, we test the suitability of a modified rotary miniPERM™ bioreactor system in inducing proliferation and osteodifferentiation of human foetal mesenchymal stem cell (hfMSC) on poly-ε-caprolactone (PCL)-tricalcium phosphate (TCP) scaffolds.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121949799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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