Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384083
Jiang Liu, Zhuo Zhang, S. M. Chin, Yikying Teo, W. K. Wong, N. Tan, Joo-Hwee Lim, Shijian Lu, Huiqi Li, T. Wong
The Genome-Wide Association (GWA) study is the latest approach in the development of genetic studies and is renowned for its widespread success in identifying disease variants within the genome for various common diseases. It is a highly popular study amongst geneticists worldwide, evident from the numerous GWA studies conducted in laboratories all over the world. This paper introduces various GWA study designs currently recognized, including other aspects such as the software tools and its progress thus far. Especially, the paper reviews the genetic studies for glaucoma, an ocular disease which can lead to irreversible and permanent vision loss. Glaucomatous progression can be slowed or even halted if detected early; however, genetic information on glaucoma has not been well established yet. Therefore, by conducting a GWA study on glaucoma to find comprehensive associated genetic variants, the early detection of glaucoma through GWA may finally be seen as a possibility.
{"title":"Genome-Wide Association study for glaucoma","authors":"Jiang Liu, Zhuo Zhang, S. M. Chin, Yikying Teo, W. K. Wong, N. Tan, Joo-Hwee Lim, Shijian Lu, Huiqi Li, T. Wong","doi":"10.1109/ICBPE.2009.5384083","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384083","url":null,"abstract":"The Genome-Wide Association (GWA) study is the latest approach in the development of genetic studies and is renowned for its widespread success in identifying disease variants within the genome for various common diseases. It is a highly popular study amongst geneticists worldwide, evident from the numerous GWA studies conducted in laboratories all over the world. This paper introduces various GWA study designs currently recognized, including other aspects such as the software tools and its progress thus far. Especially, the paper reviews the genetic studies for glaucoma, an ocular disease which can lead to irreversible and permanent vision loss. Glaucomatous progression can be slowed or even halted if detected early; however, genetic information on glaucoma has not been well established yet. Therefore, by conducting a GWA study on glaucoma to find comprehensive associated genetic variants, the early detection of glaucoma through GWA may finally be seen as a possibility.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114839203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384076
B. Notarberardino, P. Young, G. Tabor, Liang Hao, I. Turner, A. Harkara
Bio-scaffolds which are most commonly open celled porous structures are increasingly used for tissue engineering and regenerative medicine. Numerical studies exploring the influence of architecture on structural and flow characteristics of porous media have been carried out but these studies almost exclusively assume an idealized repeating unit cell approach. However, most of the traditional techniques employed to manufacture bio-scaffolds do not result in uniform pore sizes and connectivities. A number of studies have shown that the bulk properties of such irregular structures are poorly modeled using idealized unit cell approaches. Therefore, accurate modeling of bio-scaffolds with non-uniform cellular structures is very important for the development of optimal scaffolds for tissue engineering application. The paper will use novel image based meshing techniques to explore both fluid flow and bulk structural properties of a bone scaffold. The work highlights the potential use of image based meshing for the ad hoc characterization of scaffolds as well as for assisting in the design of scaffolds with tailored strength, stiffness and transport properties.
{"title":"Structural and fluid transport characterization of bio-scaffolds based on 3D imaging data","authors":"B. Notarberardino, P. Young, G. Tabor, Liang Hao, I. Turner, A. Harkara","doi":"10.1109/ICBPE.2009.5384076","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384076","url":null,"abstract":"Bio-scaffolds which are most commonly open celled porous structures are increasingly used for tissue engineering and regenerative medicine. Numerical studies exploring the influence of architecture on structural and flow characteristics of porous media have been carried out but these studies almost exclusively assume an idealized repeating unit cell approach. However, most of the traditional techniques employed to manufacture bio-scaffolds do not result in uniform pore sizes and connectivities. A number of studies have shown that the bulk properties of such irregular structures are poorly modeled using idealized unit cell approaches. Therefore, accurate modeling of bio-scaffolds with non-uniform cellular structures is very important for the development of optimal scaffolds for tissue engineering application. The paper will use novel image based meshing techniques to explore both fluid flow and bulk structural properties of a bone scaffold. The work highlights the potential use of image based meshing for the ad hoc characterization of scaffolds as well as for assisting in the design of scaffolds with tailored strength, stiffness and transport properties.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130213237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384105
M. J. Russell, D. Rubin, T. Marwala, B. Wigdorowitz
A new artificial Larynx is currently under development at the University of the Witwatersrand, Johannesburg. This device uses dynamic tongue movement from a palatometer system to infer what the user is trying to say. Feature selection algorithms extract information from the palatometer data and are then used as input to a Multi-Layer Perceptron Neural Network. This paper deals with improving the success rate of the Neural Networks by using a voting system as well as a word prediction system. By using a voting system unknown non-rejected input words were correctly identified 93.5% of the time, while the system has a rejection rate of 17.36%. A set of grammar rules were developed for the word set and this improved the number of correct unknown, non-rejected words to 94.14% but increased the rejection rate to 17.74%.
{"title":"A voting and predictive Neural Network system for use in a new artificial Larynx","authors":"M. J. Russell, D. Rubin, T. Marwala, B. Wigdorowitz","doi":"10.1109/ICBPE.2009.5384105","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384105","url":null,"abstract":"A new artificial Larynx is currently under development at the University of the Witwatersrand, Johannesburg. This device uses dynamic tongue movement from a palatometer system to infer what the user is trying to say. Feature selection algorithms extract information from the palatometer data and are then used as input to a Multi-Layer Perceptron Neural Network. This paper deals with improving the success rate of the Neural Networks by using a voting system as well as a word prediction system. By using a voting system unknown non-rejected input words were correctly identified 93.5% of the time, while the system has a rejection rate of 17.36%. A set of grammar rules were developed for the word set and this improved the number of correct unknown, non-rejected words to 94.14% but increased the rejection rate to 17.74%.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130237211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384085
S. Piriyaprasarth, V. Patomchaiviwat, P. Sriamonsak
The objective of this study was to develop neural network model of drug release from HPMC matrix tablets in terms of formulation factors and process variables. The physicochemical properties of the drug and HPMC and manufacturing process were investigated and used as independent factors. The % cumulative release of different drugs from hyroxypropylmethylcellulose (HPMC) matrix tablets was used as the response factors. The correlation between causal factors and response factor was examined using feed-forward back-propagation neural networks. The in silico model was optimized by considering goodness-of-fit and cross-validated predictability. A “leave-one-out” cross-validation revealed that the neural network model could predict release properties of drug from HPMC tablets with a reasonable accuracy (predictive r2 of 0.73–0.89 and predictive root mean square error of 1.68–8.90). The predictive ability of these models was validated by a set of 3 formulations that were not included in the training set. The predicted and observed cumulative releases (%) were well correlated.
{"title":"In silico modeling of pharmaceutical formulation using artificial neural networks","authors":"S. Piriyaprasarth, V. Patomchaiviwat, P. Sriamonsak","doi":"10.1109/ICBPE.2009.5384085","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384085","url":null,"abstract":"The objective of this study was to develop neural network model of drug release from HPMC matrix tablets in terms of formulation factors and process variables. The physicochemical properties of the drug and HPMC and manufacturing process were investigated and used as independent factors. The % cumulative release of different drugs from hyroxypropylmethylcellulose (HPMC) matrix tablets was used as the response factors. The correlation between causal factors and response factor was examined using feed-forward back-propagation neural networks. The in silico model was optimized by considering goodness-of-fit and cross-validated predictability. A “leave-one-out” cross-validation revealed that the neural network model could predict release properties of drug from HPMC tablets with a reasonable accuracy (predictive r2 of 0.73–0.89 and predictive root mean square error of 1.68–8.90). The predictive ability of these models was validated by a set of 3 formulations that were not included in the training set. The predicted and observed cumulative releases (%) were well correlated.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117225203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384093
M. Baboli, A. Sharafi, A. Ahmadian, S. Karimifard
Ultra-Wide Band (UWB) signals have become attractive for their particular advantage of having narrow pulse width which makes them suitable for remote sensing of vital signals. In this work, a MATLAB framework is presented which simulates an environment whereby the UWB signals can be observed and evaluated at different locations of the simulated channel for wireless measurement of heart rate. Main parts of the simulated system include UWB signal generator, transmitter and receiver, channel model which contains human body. The proposed system enables us to evaluate the effect of different parameters, such as thickness of channel layers and heart motion parameters on the accuracy of heart rate measurement. One of the main features of this work is employing a five layers channel model with arbitrary attenuation parameters defined by user for simulation of human body. In our experiments attenuation of transmitted Gaussian monocycle pulse centered at 4GHz frequency in each layer with different thickness for all existing multipath are calculated. Moreover, the effects of receiver sensitivity and three types of irregularities in the accuracy of measured heart rates are investigated.
{"title":"A framework for simulation of UWB system for heart rate detection","authors":"M. Baboli, A. Sharafi, A. Ahmadian, S. Karimifard","doi":"10.1109/ICBPE.2009.5384093","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384093","url":null,"abstract":"Ultra-Wide Band (UWB) signals have become attractive for their particular advantage of having narrow pulse width which makes them suitable for remote sensing of vital signals. In this work, a MATLAB framework is presented which simulates an environment whereby the UWB signals can be observed and evaluated at different locations of the simulated channel for wireless measurement of heart rate. Main parts of the simulated system include UWB signal generator, transmitter and receiver, channel model which contains human body. The proposed system enables us to evaluate the effect of different parameters, such as thickness of channel layers and heart motion parameters on the accuracy of heart rate measurement. One of the main features of this work is employing a five layers channel model with arbitrary attenuation parameters defined by user for simulation of human body. In our experiments attenuation of transmitted Gaussian monocycle pulse centered at 4GHz frequency in each layer with different thickness for all existing multipath are calculated. Moreover, the effects of receiver sensitivity and three types of irregularities in the accuracy of measured heart rates are investigated.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125265710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384100
Suisheng Tang, Zhuo Zhang, B. Pang, C. Lim, B. Ang, C. Lee, C. Tan, Tianxia Gong, Ruizhe Liu, Qi Tian
Approximately ten million people in the world suffer from traumatic brain injury (TBI) each year. A total of $60 billion cost due to TBI was estimated in the United States in year 2000. To reduce the burden more clinical research and education are required. In this study we developed MiBank, a web-based integrated TBI information system, to enable rapid access to both digital images and associated text reports for audit, education and research. MiBank contains more than 30,000 brain computed tomography (CT) images from over 500 patients and is equipped with functional options to search, compare, summarize and annotate CT images, radiology reports and clinician remarks online. The image annotation function is designed to enable clinicians and researchers to capture and display domain expert knowledge, and a discussion forum function encourages active communication and sharing. Emphasizing confidentiality of anonymised data and access control, MiBank provides a virtual collaboration platform integrating various clinical data sets for research and continuing education. As an online information system, it eliminates the restrictions of the traditional isolated DICOM workstations. MiBank can potentially support remote consulting and statistical analysis of aggregated multimodality data. Although MiBank is designed and implemented for TBI, it may be extended and customized to study other clinical disorders. In this report, we share our learning experience through user survey and also propose a future plan to improve the system. MiBank may be accessible by researchers and clinicians on request.
{"title":"MiBank: A web-based integrated medical information system for traumatic brain injury","authors":"Suisheng Tang, Zhuo Zhang, B. Pang, C. Lim, B. Ang, C. Lee, C. Tan, Tianxia Gong, Ruizhe Liu, Qi Tian","doi":"10.1109/ICBPE.2009.5384100","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384100","url":null,"abstract":"Approximately ten million people in the world suffer from traumatic brain injury (TBI) each year. A total of $60 billion cost due to TBI was estimated in the United States in year 2000. To reduce the burden more clinical research and education are required. In this study we developed MiBank, a web-based integrated TBI information system, to enable rapid access to both digital images and associated text reports for audit, education and research. MiBank contains more than 30,000 brain computed tomography (CT) images from over 500 patients and is equipped with functional options to search, compare, summarize and annotate CT images, radiology reports and clinician remarks online. The image annotation function is designed to enable clinicians and researchers to capture and display domain expert knowledge, and a discussion forum function encourages active communication and sharing. Emphasizing confidentiality of anonymised data and access control, MiBank provides a virtual collaboration platform integrating various clinical data sets for research and continuing education. As an online information system, it eliminates the restrictions of the traditional isolated DICOM workstations. MiBank can potentially support remote consulting and statistical analysis of aggregated multimodality data. Although MiBank is designed and implemented for TBI, it may be extended and customized to study other clinical disorders. In this report, we share our learning experience through user survey and also propose a future plan to improve the system. MiBank may be accessible by researchers and clinicians on request.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117332461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384108
F. Huq, A. Alshehri, P. Beale, J. Q. Yu
The present study shows that combinations of cisplatin and YH12 produce sequence- and concentration-dependent synergism in human ovarian cancer cell lines A2780 and A2780cisR. Addition of YH12 followed by cisplatin 4 h later or addition of the two compounds at the same time produces synergism whereas the addition of cisplatin first followed by YH12 4 h later results into antagonism. If the results are found to be true in vivo, they may have profound implication in the design of combination therapy.
{"title":"Synergism from combination of platinums in ovarian cancer","authors":"F. Huq, A. Alshehri, P. Beale, J. Q. Yu","doi":"10.1109/ICBPE.2009.5384108","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384108","url":null,"abstract":"The present study shows that combinations of cisplatin and YH12 produce sequence- and concentration-dependent synergism in human ovarian cancer cell lines A2780 and A2780cisR. Addition of YH12 followed by cisplatin 4 h later or addition of the two compounds at the same time produces synergism whereas the addition of cisplatin first followed by YH12 4 h later results into antagonism. If the results are found to be true in vivo, they may have profound implication in the design of combination therapy.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"180 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116897686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384063
Mahnaz Arvaneh, Hamed Ahmadi, A. Azemi, M. Shajiee, Z. S. Dastgheib
In this work, we propose a new method for prediction of Paroxysmal Atrial Fibrillation (PAF) by only using the PR interval of ECG signal. We first obtain a nonlinear structure and parameters of PR interval by a Genetic Programming (GP) based algorithm. Next, we use the neural networks for prediction of PAF. The inputs of the neural networks are the parameters of nonlinear model of the PR intervals. For the modeling and prediction we have limited ourselves to only 30 seconds of an ECG signal, which is one of the advantages of our proposed approach. For comparison purposes, we have modeled 30 seconds of ECG signals by time based modeling method and have compared prediction results of them.
{"title":"Prediction of Paroxysmal Atrial Fibrillation by dynamic modeling of the PR interval of ECG","authors":"Mahnaz Arvaneh, Hamed Ahmadi, A. Azemi, M. Shajiee, Z. S. Dastgheib","doi":"10.1109/ICBPE.2009.5384063","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384063","url":null,"abstract":"In this work, we propose a new method for prediction of Paroxysmal Atrial Fibrillation (PAF) by only using the PR interval of ECG signal. We first obtain a nonlinear structure and parameters of PR interval by a Genetic Programming (GP) based algorithm. Next, we use the neural networks for prediction of PAF. The inputs of the neural networks are the parameters of nonlinear model of the PR intervals. For the modeling and prediction we have limited ourselves to only 30 seconds of an ECG signal, which is one of the advantages of our proposed approach. For comparison purposes, we have modeled 30 seconds of ECG signals by time based modeling method and have compared prediction results of them.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134399722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384097
P. Hiremath, Jyothi R. Tegnoor
Knowledge about the status of the female reproductive system is important for fertility problems and age related family planning. The volume of these fertility requests in our emancipated society is steadily increasing. Transvaginal ultrasound imaging of the follicles in the ovary gives important information about the ovarian aging, i.e., number of follicles, size, position and response to hormonal stimulation. Manual analysis of many follicles is laborious and error-prone. In this paper, a new method for recognition of follicles in ultrasound images of ovaries is proposed. This fully automated recognition method is based on extraction of geometric features of follicles. The proposed technique is tested on ultrasonographic images of ovaries. The experimental results are compared with inferences drawn by medical expert and demonstrate the efficacy of the method.
{"title":"Recognition of follicles in ultrasound images of ovaries using geometric features","authors":"P. Hiremath, Jyothi R. Tegnoor","doi":"10.1109/ICBPE.2009.5384097","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384097","url":null,"abstract":"Knowledge about the status of the female reproductive system is important for fertility problems and age related family planning. The volume of these fertility requests in our emancipated society is steadily increasing. Transvaginal ultrasound imaging of the follicles in the ovary gives important information about the ovarian aging, i.e., number of follicles, size, position and response to hormonal stimulation. Manual analysis of many follicles is laborious and error-prone. In this paper, a new method for recognition of follicles in ultrasound images of ovaries is proposed. This fully automated recognition method is based on extraction of geometric features of follicles. The proposed technique is tested on ultrasonographic images of ovaries. The experimental results are compared with inferences drawn by medical expert and demonstrate the efficacy of the method.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123242723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-12-01DOI: 10.1109/ICBPE.2009.5384072
D. Wong, N. Tan, Jiang Liu, Z. Tan, Y. Tang, Zhuo Zhang, J. Lim, W. J. Ng, Haizhou Li, Shijian Lu, T. Y. Wong
We propose a method for improving the accuracy of the optic cup detected from the ARGALI system. This method makes use of key points from the branching points of large vessels, the analysis of intensity variation and kinks from small vessels to obtain an enhanced optic cup. Measures used to assess the detection of the optic cup showed an 11% and 40% improvement in the mean average overlap and relative area difference respectively over the previous method. The difference in the CDR error was also shown to be reduced to less than 0.1CDR units. The improved optic cup detection is more consistent with the clinical ground truth, facilitating its use in ARGALI for mass screening for glaucoma for early detection to save sight.
{"title":"Enhancement of optic cup detection from ARGALI using key points","authors":"D. Wong, N. Tan, Jiang Liu, Z. Tan, Y. Tang, Zhuo Zhang, J. Lim, W. J. Ng, Haizhou Li, Shijian Lu, T. Y. Wong","doi":"10.1109/ICBPE.2009.5384072","DOIUrl":"https://doi.org/10.1109/ICBPE.2009.5384072","url":null,"abstract":"We propose a method for improving the accuracy of the optic cup detected from the ARGALI system. This method makes use of key points from the branching points of large vessels, the analysis of intensity variation and kinks from small vessels to obtain an enhanced optic cup. Measures used to assess the detection of the optic cup showed an 11% and 40% improvement in the mean average overlap and relative area difference respectively over the previous method. The difference in the CDR error was also shown to be reduced to less than 0.1CDR units. The improved optic cup detection is more consistent with the clinical ground truth, facilitating its use in ARGALI for mass screening for glaucoma for early detection to save sight.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"401 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131497781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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