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Japanese Journal of Head and Neck Cancer最新文献

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2 Reconstruction of the Oral Tongue and Floor of Mouth 口腔舌和口腔底的重建
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.1055/b-0039-171240
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引用次数: 0
13 Reconstruction of the Oropharynx 13口咽重建
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.1055/b-0039-171251
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引用次数: 0
7 Management of Carcinoma of the Lateral Pharynx and Soft Palate 侧咽及软腭癌的治疗
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.1055/b-0039-171245
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引用次数: 0
Treatment of the cervical lymph nodes and significance of sentinel lymph nodes in early stage oral cancer 早期口腔癌颈淋巴结的治疗及前哨淋巴结的意义
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.5981/jjhnc.45.369
N. Wakisaka, T. Yoshizaki
要 旨 我々の施設で臨床的に転移を認めない早期口腔癌 40 症例について原発巣の切除のみを行い頸部は経過観察を 行った。後発転移が 22.5%で発生していた。 一部の施設ではラジオアイソトープを用いたセンチネルリンパ節(SN)同定法・生検法が導入されている。頭 頸部癌における SN 生検術は欧米では既に標準治療として位置付けられている。我が国ではようやく頭頸部癌診療 ガイドライン 2018 年版で記載されるに留まっている。 我々は,1)超音波造影剤ソナゾイドを用いた SN 同定法,と,2)超音波の新技術 Superb Microvascular Imaging による微小血流評価による SN 転移判定法を考案し,第 I 相試験を実施している。この一連の方法が確立 すれば,超音波機器さえあれば「SN の同定」から「SN における転移の有無の判定」まで,一般の外来で安全・ 確実にしかも安価で頸部郭清術の適応の有無を決めることが可能となる。
在我们的设施中,对于临床上不允许转移的40个早期口腔癌病例,只进行了原发灶的切除,颈部则进行了随访。发生后转移的占22.5%。部分设施采用了利用无线电同位素的前哨淋巴结(SN)鉴定法·活检法。SN活检术治疗头颈癌在欧美已经成为标准治疗。在我国,头颈癌诊疗指南2018年版才被写入。1)采用超声波造影剂的SN同定法;2)基于超声波新技术Superb Microvascular Imaging的微血流评估SN转移判定法。正在实施相试验。如果这一系列方法得以确立,那么只要有超声波仪器,就可以从“SN的鉴定”到“SN有无转移的判定”,在普通外来领域安全、可靠且价格低廉地决定颈部郭清术是否适合。
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引用次数: 0
A prospective observation study of Japanese patients with locally advanced squamous cell carcinoma of the head and neck treated by radiotherapy with cetuximab (JROSG12-2): interim appraisal of the safety and treatment compliance 西妥昔单抗(JROSG12-2)治疗日本局部晚期头颈部鳞状细胞癌患者的前瞻性观察研究:安全性和治疗依从性的中期评价
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.5981/jjhnc.45.330
Y. Ota, T. Kodaira, H. Fujii, M. Shimokawa, T. Nakashima, N. Monden, T. Yokota, A. Homma, S. Ueda, T. Akimoto
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引用次数: 0
The advantages and limitations of animal models of head and neck cancers 头颈部肿瘤动物模型的优点和局限性
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.5981/jjhnc.45.366
D. Sano, N. Oridate
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引用次数: 0
An analysis of the efficacy of concurrent chemoradiotherapy on hypopharyngeal and laryngeal cancer 同步放化疗治疗下咽喉癌的疗效分析
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.5981/jjhnc.45.51
Y. Hiraga, A. Okamoto, Motohiro Moriyama
要 旨 化学・放射線同時併用療法(CCRT)で治療した切除可能頭頸部扁平上皮がんのうち,下咽頭がん 29 例,喉頭 がん 25 例の計 54 例を対象に,生存率・喉頭温存率を臨床統計的に解析し,CCRT の有効性を検討した。 その結果,下咽頭がん / 喉頭がんの 2 年疾患特異的生存率(DSS)はそれぞれ 73%/ 92%,stage 別 2 年 DSS は,stage III 100% / 100%,IVA 75% / 88%,IVB 0% / 100%であった。CCRT 中の化学療法 1 コース群の 2 年 DSS62%,2+3 コース群 90%と有意差を認めた。2 年喉頭温存率は全例 89%,T 分類別では全例 / 下咽頭がん / 喉頭がんで T2 それぞれ 100% / 100% /-,T3 91%/ 92%/ 90%,T4 81%/ 91%/ 60%であった。重篤な有害事 象は,長期的胃管挿入 1 例のみであった。 以上から,当科における CCRT 治療結果において,2 年生存率・2 年喉頭温存率は比較的良好であり,一方有害 事象の発生は少ない結果であった。
采用必要化学和放射线同时联合疗法(CCRT)治疗的可切除头颈部鳞状细胞癌中,下咽癌29例,喉头癌25例,共计54例以实例为对象,从临床统计角度分析了存活率和喉保存率,探讨了CCRT的有效性。结果,下咽癌/喉癌的2年疾病特异性生存率(DSS)分别为73%/ 92%,不同stage的2年DSS分别为stage III 100% / 100%,IVA 75% /88%, ivb0% / 100%。与CCRT中化疗1疗程组的2年dss62%,2+3疗程组90%显著性差异。2年喉保存率全例89%,按T分类全例/咽癌/喉癌T2分别为100% / 100% /-,T3 91%/ 92%/ 90%,T4 81%/ 91%/占60%。严重的有害症状只有1例长期胃管插入。综上所述,在我科CCRT治疗结果中,2年生存率和2年喉保存率较好,另一方面,有害事件的发生较少。
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引用次数: 0
Clinical analysis of palliative care alone in end-stage head and neck cancer treatment 姑息治疗在终末期头颈癌治疗中的临床分析
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.5981/JJHNC.45.34
T. Wakasugi, Fumiko Takenaga, S. Ikezaki, S. Takeuchi, J. Ohkubo, Hideaki Suzuki
There are only a few reports on the terminal clinical course of patients who received palliative care alone. We retrospectively analyzed the clinical records of 130 patients with head and neck cancer who accepted a policy of palliative care alone at our institute between March 2008 and February 2018. Median overall survival (OS) was 3.6 months. Patients’ age, histological type, primary site, palliative treatment or use of opioids did not influence OS. On the other hand, OS was significantly shorter in patients with distant metastasis (p = 0.004), those who had received second-line chemotherapy (p = 0.033), intervention by the palliative care team (p = 0.023), those with steroid use (p = 0.005), and those who spent their terminal period in our hospital (p = 0.005). A significant correlation was found between the palliative treatment period and the total period of terminal care (r = 0.631, p < 0.0001). These results suggest that longer palliative treatment may extend the entire course of the terminal period. Since the survival period of patients with head and neck cancers under palliative care alone is generally short, patients’ quality of life is the most important issue to be addressed in this period.
只有少数报告的病人谁接受姑息治疗的最终临床过程单独。我们回顾性分析了2008年3月至2018年2月期间在我们研究所接受姑息治疗政策的130例头颈癌患者的临床记录。中位总生存期(OS)为3.6个月。患者的年龄、组织学类型、原发部位、姑息治疗或阿片类药物的使用对OS没有影响。另一方面,远处转移患者(p = 0.004)、接受过二线化疗(p = 0.033)、姑息治疗小组干预(p = 0.023)、使用类固醇(p = 0.005)和在我院度过末期的患者(p = 0.005)的OS明显较短。姑息治疗时间与总末期护理时间有显著相关(r = 0.631, p < 0.0001)。这些结果表明,较长的姑息治疗可能延长整个过程的终末期。由于单纯姑息治疗的头颈癌患者生存期普遍较短,患者的生活质量是这一时期最需要解决的问题。
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引用次数: 0
A case report on childhood acinic cell carcinoma of parotid gland 儿童腮腺腺泡细胞癌1例报告
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.5981/JJHNC.45.66
Hiroyuki Iuchi, H. Nagano, Y. Kurono
Acinic cell carcinoma is a relatively rare malignancy of ductal cell origin that accounts for 1–6% of salivary gland neoplasms, and often occurs in the parotid gland. Acinic cell carcinoma of the parotid gland in children is extremely rare. A 10-year-old boy was referred to our hospital because of left parotid tumor. Magnetic resonance imaging T1 examination revealed a low signal and T2 examination revealed an iso-high signal. The formation of cysts was observed inside, and many of them had hemorrhagic change. There was no characteristic finding in the preoperative imaging diagnosis, and schwannoma was considered. The maxillary branch of the facial nerve was involved in the tumor, and the facial nerve was resected. There has been no clinical evidence of recurrence or metastasis for 3 years since the surgery.
腺泡细胞癌是一种相对罕见的起源于导管细胞的恶性肿瘤,占唾液腺肿瘤的1-6%,常发生在腮腺。儿童腮腺腺泡细胞癌极为罕见。一名10岁男童因左腮腺肿瘤转介至本院。磁共振T1示低信号,T2示等高信号。内见囊肿形成,多见出血性改变。术前影像学诊断未见特征性发现,考虑神经鞘瘤。面神经上颌支累及肿瘤,切除面神经。手术后3年无复发或转移的临床证据。
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引用次数: 0
6 Reconstruction of the Palate and Maxilla 上颚及上颌骨重建
Q4 Medicine Pub Date : 2019-01-01 DOI: 10.1055/b-0039-171244
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引用次数: 0
期刊
Japanese Journal of Head and Neck Cancer
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