T. Matsuzuka, Tetsuro Kobayashi, Masahiro Suzuki, Y. Nakaegawa, Tomotaka Kawase, Y. Hasegawa, S. Murono
Discriminate potential of VTIQ between malignant tumor and benign salivary gland tumor by propagation Virtual touch tissue imaging quantification （VTIQ） is an elastography technique that measures the tissue elasticity quantitatively as the propagation velocity （Vs） of shear waves and displays tissue elasticity images. We analyzed the histological relationship of 51 salivary gland tumors whose VTIQ was measured and pathologi-cally diagnosed from 2016 to 2019 at Fukushima Medical University Hospital. There were 11 malignant tumors, 21 benign tumors with pleomorphic adenoma, and 19 other benign tumors, and Vs and tissue elasticity images were compared among the three groups. Vs of 4.8m/s or higher was 45％ overall, 91％ for malignant tumors, 55％ for pleomorphic adenomas, and 0％ for other benign tumors. Vs for pleomorphic adenomas had a large range and was difficult to distinguish from that for malignant tumors. The tissue elasticity images of each tumor were classified into four types: 91％ of malignant tumors and 10％ of pleomorphic adenomas were the homogeneous type or geographic type, and 9％ of malignant tumors and 67％ of pleomorphic adenomas were the mottled type. Although it was difficult to discriminate by Vs, it may be possible to discriminate between malignant tumors and pleomorphic adenomas by tissue elasticity images.
{"title":"Discriminate potential of VTIQ between malignant tumor and benign salivary gland tumor by propagation velocity and tissue elasticity image","authors":"T. Matsuzuka, Tetsuro Kobayashi, Masahiro Suzuki, Y. Nakaegawa, Tomotaka Kawase, Y. Hasegawa, S. Murono","doi":"10.5981/JJHNC.47.30","DOIUrl":"https://doi.org/10.5981/JJHNC.47.30","url":null,"abstract":"Discriminate potential of VTIQ between malignant tumor and benign salivary gland tumor by propagation Virtual touch tissue imaging quantification （VTIQ） is an elastography technique that measures the tissue elasticity quantitatively as the propagation velocity （Vs） of shear waves and displays tissue elasticity images. We analyzed the histological relationship of 51 salivary gland tumors whose VTIQ was measured and pathologi-cally diagnosed from 2016 to 2019 at Fukushima Medical University Hospital. There were 11 malignant tumors, 21 benign tumors with pleomorphic adenoma, and 19 other benign tumors, and Vs and tissue elasticity images were compared among the three groups. Vs of 4.8m/s or higher was 45％ overall, 91％ for malignant tumors, 55％ for pleomorphic adenomas, and 0％ for other benign tumors. Vs for pleomorphic adenomas had a large range and was difficult to distinguish from that for malignant tumors. The tissue elasticity images of each tumor were classified into four types: 91％ of malignant tumors and 10％ of pleomorphic adenomas were the homogeneous type or geographic type, and 9％ of malignant tumors and 67％ of pleomorphic adenomas were the mottled type. Although it was difficult to discriminate by Vs, it may be possible to discriminate between malignant tumors and pleomorphic adenomas by tissue elasticity images.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tsuyoshi Takemoto, H. Orita, Y. Okazaki, R. Murakami, Ritsuko Miyauchi
We report a case of basal cell adenocarcinoma (BCAC) of the hard palate. A 63-year-old woman visited our hospital because of swelling of the left cheek. The tumor occupied the hard palate and gingiva on her left side. CT scan and MRI scan revealed that the tumor had destroyed her maxillary bone and invaded the infraorbital wall and skin of the cheek. Pathological examination revealed that the tumor was BCAC. The tumor was resected, including the maxillary bone, skin of the cheek and orbital periosteum. After resection, we reconstructed her hard palate using a vascularized iliac flap with internal oblique muscle and reconstructed her cheek skin using a cervicofacial flap. However, the cervicofacial flap became partially necrotic three weeks after operation, so we reconstructed her cheek skin using a median forehead flap.
{"title":"A case of basal cell adenocarcinoma of the hard palate which progressed to the cheek","authors":"Tsuyoshi Takemoto, H. Orita, Y. Okazaki, R. Murakami, Ritsuko Miyauchi","doi":"10.5981/jjhnc.47.353","DOIUrl":"https://doi.org/10.5981/jjhnc.47.353","url":null,"abstract":"We report a case of basal cell adenocarcinoma (BCAC) of the hard palate. A 63-year-old woman visited our hospital because of swelling of the left cheek. The tumor occupied the hard palate and gingiva on her left side. CT scan and MRI scan revealed that the tumor had destroyed her maxillary bone and invaded the infraorbital wall and skin of the cheek. Pathological examination revealed that the tumor was BCAC. The tumor was resected, including the maxillary bone, skin of the cheek and orbital periosteum. After resection, we reconstructed her hard palate using a vascularized iliac flap with internal oblique muscle and reconstructed her cheek skin using a cervicofacial flap. However, the cervicofacial flap became partially necrotic three weeks after operation, so we reconstructed her cheek skin using a median forehead flap.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Jingu, N. Takahashi, S. Tasaka, R. Umezawa, Takaya Yamamoto, Y. Ishikawa, K. Takeda, Yu Suzuki, N. Kadoya, H. Matsushita
Long-term Xerostomia is one of the most common adverse events of radiotherapy （RT） in head and neck cancer patients. The salivary glands are highly sensitive to and damaged by radiation, leading to xerostomia, which de-creases patientsʼ quality of life （QOL） after radiotherapy. The purpose of this study was to evaluate long-term changes of oral health related QOL after definitive RT. Patients who were treated by RT with 60Gy or more for head and neck cancer were analyzed retrospectively. Patients with recurrence were excluded. Oral health related QOL was assessed with the General Oral Health Assessment Index （GOHAI） at follow-up dates. Sixty-six patients without recurrence were enrolled in this study. Oral health related QOL decreased rapidly during RT and recovered to the same level as normal in 3-3.5 months after the completion of RT. The nadir of GOHAI score appeared immediately after radiotherapy and the score had recovered significantly in all periods. There was no significant difference in changes in oral related QOL after RT between patients with a mean irradiated dose to the bilateral parotid glands of less than 35Gy and those of 35Gy or more.
{"title":"Long-term change in the oral health related QOL of patients treated with definitive radiotherapy for head and neck cancer","authors":"K. Jingu, N. Takahashi, S. Tasaka, R. Umezawa, Takaya Yamamoto, Y. Ishikawa, K. Takeda, Yu Suzuki, N. Kadoya, H. Matsushita","doi":"10.5981/jjhnc.47.290","DOIUrl":"https://doi.org/10.5981/jjhnc.47.290","url":null,"abstract":"Long-term Xerostomia is one of the most common adverse events of radiotherapy （RT） in head and neck cancer patients. The salivary glands are highly sensitive to and damaged by radiation, leading to xerostomia, which de-creases patientsʼ quality of life （QOL） after radiotherapy. The purpose of this study was to evaluate long-term changes of oral health related QOL after definitive RT. Patients who were treated by RT with 60Gy or more for head and neck cancer were analyzed retrospectively. Patients with recurrence were excluded. Oral health related QOL was assessed with the General Oral Health Assessment Index （GOHAI） at follow-up dates. Sixty-six patients without recurrence were enrolled in this study. Oral health related QOL decreased rapidly during RT and recovered to the same level as normal in 3-3.5 months after the completion of RT. The nadir of GOHAI score appeared immediately after radiotherapy and the score had recovered significantly in all periods. There was no significant difference in changes in oral related QOL after RT between patients with a mean irradiated dose to the bilateral parotid glands of less than 35Gy and those of 35Gy or more.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Abe, Yu Ito, Hiroki Hayashi, Takanori Ishihama, H. Furuta, Hiroshi Horibe, K. Tange
A clinicopathological study, focusing on local recurrence, was performed on 107 patients who were histologically diagnosed with oral squamous cell carcinoma and who underwent radical surgery at the Department of Oral and Maxillofacial Surgery of Nagoya Ekisaikai Hospital between January 2007 and March 2020. Among these 107 patients, 14 developed local recurrence with a recurrence rate of 13.1％. The median interval between surgery and local recurrence was 293.5 days （range: 21-1,408 days）. An analysis of the risk factors for local recurrence was performed, and depth of invasion was identified as an independent risk factor. Salvage treatments included surgery in 7 patients, radiation and chemoradiotherapy in 4 patients, and palliative care in 3 patients. Seven of the 11 patients （63.6％） were successfully salvaged. Analysis of the patients with local recurrence showed that the surgery resulted in a better outcome. However, further studies are needed to analyze the risk factors for the recurrence and efficacy of the salvage treatments from multiple perspectives.
{"title":"Clinicopathological study on local recurrence of primary oral squamous cell carcinoma","authors":"A. Abe, Yu Ito, Hiroki Hayashi, Takanori Ishihama, H. Furuta, Hiroshi Horibe, K. Tange","doi":"10.5981/JJHNC.47.35","DOIUrl":"https://doi.org/10.5981/JJHNC.47.35","url":null,"abstract":"A clinicopathological study, focusing on local recurrence, was performed on 107 patients who were histologically diagnosed with oral squamous cell carcinoma and who underwent radical surgery at the Department of Oral and Maxillofacial Surgery of Nagoya Ekisaikai Hospital between January 2007 and March 2020. Among these 107 patients, 14 developed local recurrence with a recurrence rate of 13.1％. The median interval between surgery and local recurrence was 293.5 days （range: 21-1,408 days）. An analysis of the risk factors for local recurrence was performed, and depth of invasion was identified as an independent risk factor. Salvage treatments included surgery in 7 patients, radiation and chemoradiotherapy in 4 patients, and palliative care in 3 patients. Seven of the 11 patients （63.6％） were successfully salvaged. Analysis of the patients with local recurrence showed that the surgery resulted in a better outcome. However, further studies are needed to analyze the risk factors for the recurrence and efficacy of the salvage treatments from multiple perspectives.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yusuke Nakata, Y. Demizu, T. Okimoto, Takeshi Shimizu
A 41-year old man with nasopharyngeal adenoid cystic carcinoma （T4aN0M0） received carbon ion radiotherapy of 65 Gy （RBE） in 25 fractions. The treatment was well tolerated and complete response was obtained. At 30 months after the therapy, mucosal necrosis and brain necrosis were observed as a late toxicity. Despite treatment with oral steroid, brain necrosis worsened and osteonecrosis of the skull base and cervical spine was newly observed. The patient died of intracranial infection caused by mucosal necrosis, brain necrosis and osteonecrosis of the skull base and cervical spine at 54 months after the carbon ion radiotherapy. A pathological au-topsy revealed no recurrence of adenoid cystic carcinoma. Carbon ion radiotherapy may be a useful treatment option for radioresistant malignant tumors of the head and neck. Optimal treatment planning and long-term careful follow-up are necessary to control fatal late toxicities.
{"title":"A case of treatment related death caused by mucosal necrosis, brain necrosis and osteonecrosis after carbon ion radiotherapy in nasopharyngeal adenoid cystic carcinoma","authors":"Yusuke Nakata, Y. Demizu, T. Okimoto, Takeshi Shimizu","doi":"10.5981/JJHNC.47.71","DOIUrl":"https://doi.org/10.5981/JJHNC.47.71","url":null,"abstract":"A 41-year old man with nasopharyngeal adenoid cystic carcinoma （T4aN0M0） received carbon ion radiotherapy of 65 Gy （RBE） in 25 fractions. The treatment was well tolerated and complete response was obtained. At 30 months after the therapy, mucosal necrosis and brain necrosis were observed as a late toxicity. Despite treatment with oral steroid, brain necrosis worsened and osteonecrosis of the skull base and cervical spine was newly observed. The patient died of intracranial infection caused by mucosal necrosis, brain necrosis and osteonecrosis of the skull base and cervical spine at 54 months after the carbon ion radiotherapy. A pathological au-topsy revealed no recurrence of adenoid cystic carcinoma. Carbon ion radiotherapy may be a useful treatment option for radioresistant malignant tumors of the head and neck. Optimal treatment planning and long-term careful follow-up are necessary to control fatal late toxicities.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kinoshita, M. Hara, Kazuhiro Mitsumura, M. Ōsaki, Eikichi Tokunaga, Akio Hatanaka, W. Nishijima
We encountered a patient who underwent cochlear implant surgery for bilateral severe hearing loss after administration of cisplatin. The patient was a 69-year-old man who received cisplatin and vinorelbine as post-operative chemotherapy for lung cancer. On day 7 of administration, the patient experienced hearing loss. On day 9, pure tone audiometry showed bilateral deafness. The patient also developed a renal disorder, but it subsequently improved. As hearing aids were ineffective, cochlear implantation was performed to treat the bilateral severe hearing loss. The patientʼs hearing ability was favorable immediately after the implantation. This case shows that hearing loss can be induced by cisplatin after not only dose accumulation but also single administration. Identifying genes related to cisplatin-induced hearing loss to predict post-administration hearing can contribute to a safer cancer treatment plan. Currently, there is no method for predicting or preventing the onset of hearing loss; therefore, cochlear implant surgery may be the only option for patients who develop bilateral severe hearing loss after the first administration of cisplatin.
{"title":"Cochlear implantation for bilateral severe hearing loss after a single administration of cisplatin: A case report","authors":"S. Kinoshita, M. Hara, Kazuhiro Mitsumura, M. Ōsaki, Eikichi Tokunaga, Akio Hatanaka, W. Nishijima","doi":"10.5981/JJHNC.47.78","DOIUrl":"https://doi.org/10.5981/JJHNC.47.78","url":null,"abstract":"We encountered a patient who underwent cochlear implant surgery for bilateral severe hearing loss after administration of cisplatin. The patient was a 69-year-old man who received cisplatin and vinorelbine as post-operative chemotherapy for lung cancer. On day 7 of administration, the patient experienced hearing loss. On day 9, pure tone audiometry showed bilateral deafness. The patient also developed a renal disorder, but it subsequently improved. As hearing aids were ineffective, cochlear implantation was performed to treat the bilateral severe hearing loss. The patientʼs hearing ability was favorable immediately after the implantation. This case shows that hearing loss can be induced by cisplatin after not only dose accumulation but also single administration. Identifying genes related to cisplatin-induced hearing loss to predict post-administration hearing can contribute to a safer cancer treatment plan. Currently, there is no method for predicting or preventing the onset of hearing loss; therefore, cochlear implant surgery may be the only option for patients who develop bilateral severe hearing loss after the first administration of cisplatin.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kohki Tohyama, Y. Kano, Rika Noji, Yasuko Aoyagi, Shotaro Matsudera, K. Ohno, Yosuke Ariizumi, Y. Michi, H. Tomioka, H. Shimamoto, R. Yoshimura, T. Asakage, H. Harada, S. Miyake, M. Miura, S. Ikeda
{"title":"The clinical utility of comprehensive genomic profiling for recurrent / metastatic head and neck cancer","authors":"Kohki Tohyama, Y. Kano, Rika Noji, Yasuko Aoyagi, Shotaro Matsudera, K. Ohno, Yosuke Ariizumi, Y. Michi, H. Tomioka, H. Shimamoto, R. Yoshimura, T. Asakage, H. Harada, S. Miyake, M. Miura, S. Ikeda","doi":"10.5981/jjhnc.47.359","DOIUrl":"https://doi.org/10.5981/jjhnc.47.359","url":null,"abstract":"要 旨 頭頸部癌患者 14 例 18 件に対し FoundationOne CDx などのがん遺伝子パネル検査を使用し,組織検体 15 件(83.3%),血液検体 3 件(16.6%)における遺伝子変異の解析を行った。原発部位別では,舌癌が 6 例(42.8%) と最多で,検出された遺伝子変異としては TP53,TERT promoter,CDKN2A などであり,全ゲノム解析を 用いた既報と矛盾しない結果となった。14 例のうち,治療候補があった症例は 11 例(78.6%)であったが, 実際に遺伝子パネル検査に基づいて治療を行った症例は 2 例(14.3%)であり治療薬へのアクセス率の向上が 今後の課題となった。また,TMB(Tumor Mutational Burden)が高値を示した 3 症例のうち 2 例で免疫チェッ クポイント阻害剤による奏効が得られ,TMB が頭頸部癌の実臨床における新たなバイオマーカーとして有用 である可能性が示唆された。","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Virtual reality is a rapidly developing technology in the field of computer science and can contribute to surgical care. The mixed reality （MR） technique is the merging of real and virtual worlds and provides the user with a hologram in the real world. Here, we report a new cadaver training technique with holograms called hybrid cadaver training. The MR technique makes it possible to show teaching materials as holograms during cadaver training. The application for the MR was developed by the faculty of engineering, Ehime University. Four oto-laryngology-head and neck surgery residents participated in the hybrid cadaver training and answered a ques-tionnaire. All participants rated the usefulness of the training as 5 points out of 5. The hybrid cadaver training with holograms may be a new promising simulation training for otolaryngology-head and neck surgery residents.
{"title":"Hybrid cadaver training with holograms by mixed reality technique","authors":"Kayo Sakamoto, Sohei Mitani, Eriko Sato, Takashi Kitani, Tomoyoshi Sanada, N. Hato","doi":"10.5981/jjhnc.47.366","DOIUrl":"https://doi.org/10.5981/jjhnc.47.366","url":null,"abstract":"Virtual reality is a rapidly developing technology in the field of computer science and can contribute to surgical care. The mixed reality （MR） technique is the merging of real and virtual worlds and provides the user with a hologram in the real world. Here, we report a new cadaver training technique with holograms called hybrid cadaver training. The MR technique makes it possible to show teaching materials as holograms during cadaver training. The application for the MR was developed by the faculty of engineering, Ehime University. Four oto-laryngology-head and neck surgery residents participated in the hybrid cadaver training and answered a ques-tionnaire. All participants rated the usefulness of the training as 5 points out of 5. The hybrid cadaver training with holograms may be a new promising simulation training for otolaryngology-head and neck surgery residents.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katsuji Asano, Y. Somekawa, K. Takano, M. Kurose, Shigeru Koshiba, Yousuke Nagai, M. Myoujin, Hikaru Ikeda, M. Nishio
The author performed larynx-conserving surgery on a total of 82 patients （59 primary cases and 23 secondary cases） of laryngeal cancer. The disease-specific 5-year survival rate of all 82 patients was 92.6％. The larynx con-servation rate was 87.8％ in all 82 cases. In regard to the treatment of early-stage laryngeal cancer （T1, 2）, we suggested that larynx-conserving surgery should be considered as an option for initial treatment because it is not inferior to radiotherapy in terms of clinical outcome and preservation of laryngeal function in daily life. Larynx-conserving surgery as a salvage treatment for recurrence did not present a lower laryngeal preservation rate than for primary cases, and seemed to be an effective method of salvage surgery for recurrent patients. these 11 cases, 5 cases whose surgical margins were diagnosed as negative on histopathological examination suffered local recurrence. We performed total laryngectomy as a salvage surgery on these 5 cases. Of the 16 cases of locally advanced cancer （T3, 4）, 5 cases （1 case of deep tongue muscle invasion, 3 cases of anterior invasion of the epiglottis, and 1 case of anterior wall invasion of the cricoid cartilage） showed no local recurrence and local control was successfully achieved with surgery alone. Regarding indications, in the case of locally advanced laryngeal cancer involving anterior invasion of the epiglottis, deep tongue muscle invasion, and anterior wall invasion of the cricoid cartilage, larynx-conserving surgery appropriately indicated because the cases were local controlled with surgery alone. However, in the case of recurrence, postoperative radiotherapy should be considered because of the difficulty of preserving the function of the larynx.
{"title":"82 cases of laryngeal preservation surgery for laryngeal cancer","authors":"Katsuji Asano, Y. Somekawa, K. Takano, M. Kurose, Shigeru Koshiba, Yousuke Nagai, M. Myoujin, Hikaru Ikeda, M. Nishio","doi":"10.5981/jjhnc.47.371","DOIUrl":"https://doi.org/10.5981/jjhnc.47.371","url":null,"abstract":"The author performed larynx-conserving surgery on a total of 82 patients （59 primary cases and 23 secondary cases） of laryngeal cancer. The disease-specific 5-year survival rate of all 82 patients was 92.6％. The larynx con-servation rate was 87.8％ in all 82 cases. In regard to the treatment of early-stage laryngeal cancer （T1, 2）, we suggested that larynx-conserving surgery should be considered as an option for initial treatment because it is not inferior to radiotherapy in terms of clinical outcome and preservation of laryngeal function in daily life. Larynx-conserving surgery as a salvage treatment for recurrence did not present a lower laryngeal preservation rate than for primary cases, and seemed to be an effective method of salvage surgery for recurrent patients. these 11 cases, 5 cases whose surgical margins were diagnosed as negative on histopathological examination suffered local recurrence. We performed total laryngectomy as a salvage surgery on these 5 cases. Of the 16 cases of locally advanced cancer （T3, 4）, 5 cases （1 case of deep tongue muscle invasion, 3 cases of anterior invasion of the epiglottis, and 1 case of anterior wall invasion of the cricoid cartilage） showed no local recurrence and local control was successfully achieved with surgery alone. Regarding indications, in the case of locally advanced laryngeal cancer involving anterior invasion of the epiglottis, deep tongue muscle invasion, and anterior wall invasion of the cricoid cartilage, larynx-conserving surgery appropriately indicated because the cases were local controlled with surgery alone. However, in the case of recurrence, postoperative radiotherapy should be considered because of the difficulty of preserving the function of the larynx.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：