Pub Date : 2020-01-01DOI: 10.1007/978-3-030-27881-6_14
C. Fundakowski
{"title":"In Their Words","authors":"C. Fundakowski","doi":"10.1007/978-3-030-27881-6_14","DOIUrl":"https://doi.org/10.1007/978-3-030-27881-6_14","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86369610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Kinjo, Y. Yamashita, T. Ikegami, Yuki Kayo, J. Uezato, S. Agena, Takayuki Uehara, H. Hirakawa, H. Maeda, Mikio Suzuki
{"title":"Clinical features of death cases in human papillomavirus related oropharyngeal carcinoma","authors":"H. Kinjo, Y. Yamashita, T. Ikegami, Yuki Kayo, J. Uezato, S. Agena, Takayuki Uehara, H. Hirakawa, H. Maeda, Mikio Suzuki","doi":"10.5981/jjhnc.45.397","DOIUrl":"https://doi.org/10.5981/jjhnc.45.397","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71242904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical analysis for head and neck cancer cases treated with nivolumab in Osaka International Cancer Institute","authors":"Tomoyuki Otsuka, Takayuki Kimura, R. Koike, Hironori Cho, S. Otozai, T. Yoshii, T. Yagi, T. Fujii","doi":"10.5981/JJHNC.45.46","DOIUrl":"https://doi.org/10.5981/JJHNC.45.46","url":null,"abstract":"要 旨 CheckMate 141 試験において,再発・転移性頭頸部扁平上皮癌に対してニボルマブは医師選択治療と比較して 全生存期間(OS)を有意に延長することが示された。しかし,同試験には扁平上皮癌以外の組織型および上咽頭 癌は含まれていない。今回我々は,当院でニボルマブを投与した頭頸部癌 28 例について後方視的に検討した。本 検討では,非扁平上皮癌が 2 例,上咽頭癌が 9 例含まれていた。全症例の無増悪生存期間(PFS)中央値 4.3 ヶ 月,OS 中央値は未到達であった。測定可能病変を有する 24 例の検討で,奏効率は 16.7%,病勢コントロール率は 54.2%であった。免疫関連有害事象(irAE)は 46.4%で発症し,Grade 3 の irAE は 7.1%で発症した。irAE 発症 群は未発症群と比較して有意な PFS の延長が示された。本検討では非扁平上皮癌や上咽頭癌の症例が含まれてい たが,ニボルマブの有効性が示されていた。","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71242975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hiroyuki Yamada, Tomohito Fuke, Kohei Fukukita, Mamika Kaneko, Masahiro Sawa, K. Ueda, D. Kobayashi
Surgical therapy is the main strategy for medullary thyroid cancer, but there is no effective therapy for resectable advanced cases. Vandetanib is a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor signaling. We experienced a case medicated by Vandetanib for medullary thyroid cancer. A 55-year-old female was diagnosed with medullary thyroid cancer by aspiration cytology of a thyroid tumor and needle biopsy histology. Since FDG-PET showed multiple bone metastases, she was treated with Vandetanib. Serum calcitonin and carcinoembryonic antigen decreased after withdrawal of the medication, and US showed decreased size of the thyroid tumor and cervical lymph nodes similarly. Since PET-CT showed decreased accumulation into these nodules, she was judged to have responded to the treatment. Though Vandetanib is a first-line TKI for unresectable medullary thyroid cancer, the purpose of this therapy is to control progression of the cancer.
{"title":"Effectiveness of Vandetanib for unresectable medullary thyroid cancer","authors":"Hiroyuki Yamada, Tomohito Fuke, Kohei Fukukita, Mamika Kaneko, Masahiro Sawa, K. Ueda, D. Kobayashi","doi":"10.5981/jjhnc.45.71","DOIUrl":"https://doi.org/10.5981/jjhnc.45.71","url":null,"abstract":"Surgical therapy is the main strategy for medullary thyroid cancer, but there is no effective therapy for resectable advanced cases. Vandetanib is a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal growth factor receptor signaling. We experienced a case medicated by Vandetanib for medullary thyroid cancer. A 55-year-old female was diagnosed with medullary thyroid cancer by aspiration cytology of a thyroid tumor and needle biopsy histology. Since FDG-PET showed multiple bone metastases, she was treated with Vandetanib. Serum calcitonin and carcinoembryonic antigen decreased after withdrawal of the medication, and US showed decreased size of the thyroid tumor and cervical lymph nodes similarly. Since PET-CT showed decreased accumulation into these nodules, she was judged to have responded to the treatment. Though Vandetanib is a first-line TKI for unresectable medullary thyroid cancer, the purpose of this therapy is to control progression of the cancer.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3 Carcinoma of the Buccal Mucosa","authors":"","doi":"10.1055/b-0039-171241","DOIUrl":"https://doi.org/10.1055/b-0039-171241","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74761915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"27 Surveillance of the Patient","authors":"","doi":"10.1055/b-0039-171265","DOIUrl":"https://doi.org/10.1055/b-0039-171265","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83830502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of double cancer performing total laryngectomy and transhiatal esophagectomy preserving hypopharyngeal mucosa","authors":"Tomohito Fuke, Hiroyuki Yamada, Kohei Fukukita, Mamika Kaneko, Masahiro Sawa, K. Ueda, D. Kobayashi","doi":"10.5981/jjhnc.45.61","DOIUrl":"https://doi.org/10.5981/jjhnc.45.61","url":null,"abstract":"要 旨 頭頸部癌治療では重複癌の検索は必須であり,同時重複癌が判明した場合には原発巣や転移部のみならず,患 者の社会的背景や全身状態も考慮した上で治療方針を決定する必要がある。今回,食道癌を合併した喉頭癌症例 に対して同時手術を行った症例を提示する。症例は 72 歳男性で,既往歴として脊髄小脳変性症があった。左声門 T3N2bM0 の精査中に,食道表在癌(Mt,Pw,0-IIc,T1b-SM)が判明した。咽喉頭摘出および食道抜去,挙上胃 管による咽頭食道再建も考慮したが,リスク因子(脊髄小脳変性症の基礎疾患,高度喫煙による閉塞障害)を考慮 して,喉頭摘出・非開胸食道抜去術を行った。喉頭摘出時に可能な限り下咽頭粘膜を温存し,残存する咽頭食道粘 膜の血流障害がないことを確認し,咽頭縫合して縫合不全の軽減目的に甲状腺で被覆し,その尾側で挙上胃管と吻 合した。手術 13 日後より経口摂取を開始したが縫合不全はなく,再発転移はみられていない。","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"14 Carcinoma of the Hypopharynx","authors":"","doi":"10.1055/b-0039-171252","DOIUrl":"https://doi.org/10.1055/b-0039-171252","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81782882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"29 The Vessel-Depleted Neck: Microvascular Reconstruction","authors":"","doi":"10.1055/b-0039-171267","DOIUrl":"https://doi.org/10.1055/b-0039-171267","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83454061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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