A. Arai, Nariyasu Ishizaka, N. Tadaki, Rei Murakami, Hitosuke Tameno, K. Kayano, K. Tei, S. Koike, K. Nobuhara, H. Okano, Hiroki Morimoto, G. Omura, T. Tsujikawa, Y. Sugiyama, S. Hirano
{"title":"An interim analysis of malnutrition and prognosis in elderly head and neck cancer patient: Koto-SG multicenter research","authors":"A. Arai, Nariyasu Ishizaka, N. Tadaki, Rei Murakami, Hitosuke Tameno, K. Kayano, K. Tei, S. Koike, K. Nobuhara, H. Okano, Hiroki Morimoto, G. Omura, T. Tsujikawa, Y. Sugiyama, S. Hirano","doi":"10.5981/jjhnc.47.329","DOIUrl":"https://doi.org/10.5981/jjhnc.47.329","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Toshifumi Tomioka, K. Matsuura, Y. Morishita, W. Okano, T. Shinozaki, T. Yano, R. Hayashi
Background: Recent developments in transoral surgery （TOS） have improved outcomes in early-stage hypopharyngeal cancer. To date, however, indications for TOS and partial pharyngectomy with primary closure （PP-PC）, which is also used in these early-stage diseases, have not been considered in detail. Here, we investigated whether TOS could be used as minimally invasive surgery while maintaining outcomes comparable to those of PP-PC. Methods: This was a single-center retrospective case control study. Median follow-up period was 59.4 months （1.2-174） for TOS and 88.8 months （3.6-158.4） for PP-PC. Patients who received initial surgical treatment for hypopharyngeal cancer were recruited from 2002 through 2014. Among these patients who underwent TOS or PP-PC, cT1-3N0M0 was included. Those with histopathological invasion of the muscularis propria were excluded. Of 117 consecutive cases, 87 cases were treated with TOS and 30 with PP-PC. Median age was 66 years （42-88）. Lesions were in the pyriform sinus （PS） in 91 cases, posterior wall （PW） in 18, and postcricoid area （PC） in 8. cT classification was cT1 in 62 cases, cT2 in 51, and cT3 in 4. We compared patients by patient background; prognosis, including postoperative complications; Results: Median operation time was 40 minutes （12-240） for TOS and 118 minutes （58-250） for PP-PC. Postoperative complications occurred in 10 cases （10/87, 11.5％） with TOS and 10 （10/30, 33.3％） with PP-PC （P ＝ 0.0275）. postoperative hospital stay was 7 days （4-137） with TOS and 15 days （9-37） with PP-PC （P ＝ 0.002）. function Five-year overall survival rate for 0.99）. hypopharyngeal cancer （cT1N0, cT2N0 and some cT3N0 without muscular infiltration）.
背景:经口手术(TOS)的最新进展改善了早期下咽癌的预后。然而，到目前为止，还没有详细考虑TOS和部分咽切除术并初级关闭(PP-PC)的适应症，这也用于这些早期疾病。在这里，我们研究了TOS是否可以作为微创手术，同时保持与PP-PC相当的结果。方法:本研究为单中心回顾性病例对照研究。TOS的中位随访时间为59.4个月(1.2-174)，PP-PC的中位随访时间为88.8个月(3.6-158.4)。从2002年到2014年招募了接受下咽癌初始手术治疗的患者。在这些接受TOS或PP-PC的患者中，包括c1 - 3n0m0。排除组织病理学上侵犯固有肌层者。117例患者中，87例采用TOS治疗，30例采用PP-PC治疗。中位年龄为66岁(42-88岁)。梨状窦91例，后壁18例，环后区8例。cT分型cT1 62例，cT2 51例，cT3 4例。我们根据患者背景对患者进行比较;预后，包括术后并发症;结果:TOS手术中位时间为40分钟(12 ~ 240分钟)，PP-PC手术中位时间为118分钟(58 ~ 250分钟)。TOS组10例(10/87,11.5%)，PP-PC组10例(10/30,33.3%)出现术后并发症(P = 0.0275)。TOS组术后住院时间为7 d (4-137)， PP-PC组术后住院时间为15 d (9-37) (P = 0.002)。5年总生存率为0.99)。下咽癌(cT1N0、cT2N0及部分cT3N0无肌肉浸润)。
{"title":"Comparison of trans oral surgery and partial pharyngectomy with primary closure for early stage hypopharyngeal cancer","authors":"Toshifumi Tomioka, K. Matsuura, Y. Morishita, W. Okano, T. Shinozaki, T. Yano, R. Hayashi","doi":"10.5981/jjhnc.47.267","DOIUrl":"https://doi.org/10.5981/jjhnc.47.267","url":null,"abstract":"Background: Recent developments in transoral surgery （TOS） have improved outcomes in early-stage hypopharyngeal cancer. To date, however, indications for TOS and partial pharyngectomy with primary closure （PP-PC）, which is also used in these early-stage diseases, have not been considered in detail. Here, we investigated whether TOS could be used as minimally invasive surgery while maintaining outcomes comparable to those of PP-PC. Methods: This was a single-center retrospective case control study. Median follow-up period was 59.4 months （1.2-174） for TOS and 88.8 months （3.6-158.4） for PP-PC. Patients who received initial surgical treatment for hypopharyngeal cancer were recruited from 2002 through 2014. Among these patients who underwent TOS or PP-PC, cT1-3N0M0 was included. Those with histopathological invasion of the muscularis propria were excluded. Of 117 consecutive cases, 87 cases were treated with TOS and 30 with PP-PC. Median age was 66 years （42-88）. Lesions were in the pyriform sinus （PS） in 91 cases, posterior wall （PW） in 18, and postcricoid area （PC） in 8. cT classification was cT1 in 62 cases, cT2 in 51, and cT3 in 4. We compared patients by patient background; prognosis, including postoperative complications; Results: Median operation time was 40 minutes （12-240） for TOS and 118 minutes （58-250） for PP-PC. Postoperative complications occurred in 10 cases （10/87, 11.5％） with TOS and 10 （10/30, 33.3％） with PP-PC （P ＝ 0.0275）. postoperative hospital stay was 7 days （4-137） with TOS and 15 days （9-37） with PP-PC （P ＝ 0.002）. function Five-year overall survival rate for 0.99）. hypopharyngeal cancer （cT1N0, cT2N0 and some cT3N0 without muscular infiltration）.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Mizoguchi, K. Shirai, Kio Kano, Wataru Anno, K. Tsuchida, Y. Takakusagi, Itsuko Serizawa, K. Akahane, Masahiro Kawahara, T. Kamada, D. Yoshida, H. Katoh
Radiotherapy for adenoid cystic carcinoma of the head and neck : Nobutaka Mizoguchi1, 2), Katsuyuki Shirai2, 3), Kio Kano1), Wataru Anno1), Keisuke Tsuchida1), Yosuke Takakusagi1), Itsuko Serizawa1), Keiko Akahane2), Masahiro Kawahara2), Tadashi Kamada1), Daisaku Yoshida1) and Hiroyuki Katoh1) 1)Department of Radiation Oncology, Kanagawa Cancer Center 2)Department of Radiology, Saitama Medical Center, Jichi Medical University 3)Department of Radiation Oncology, Jichi Medical University Hospital
{"title":"Radiotherapy for adenoid cystic carcinoma of the head and neck","authors":"N. Mizoguchi, K. Shirai, Kio Kano, Wataru Anno, K. Tsuchida, Y. Takakusagi, Itsuko Serizawa, K. Akahane, Masahiro Kawahara, T. Kamada, D. Yoshida, H. Katoh","doi":"10.5981/jjhnc.47.279","DOIUrl":"https://doi.org/10.5981/jjhnc.47.279","url":null,"abstract":"Radiotherapy for adenoid cystic carcinoma of the head and neck : Nobutaka Mizoguchi1, 2), Katsuyuki Shirai2, 3), Kio Kano1), Wataru Anno1), Keisuke Tsuchida1), Yosuke Takakusagi1), Itsuko Serizawa1), Keiko Akahane2), Masahiro Kawahara2), Tadashi Kamada1), Daisaku Yoshida1) and Hiroyuki Katoh1) 1)Department of Radiation Oncology, Kanagawa Cancer Center 2)Department of Radiology, Saitama Medical Center, Jichi Medical University 3)Department of Radiation Oncology, Jichi Medical University Hospital","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Kosugi, T. Kawamoto, M. Oshima, Michimasa Suzuki, M. Fujimaki, S. Ohba, F. Matsumoto, N. Shikama, K. Sasai
We retrospectively analyzed the frequency of retropharyngeal lymph node （Rp） metastasis on diagnostic images and the irradiation dose to the same area in 55 patients with advanced maxillary sinus squamous cell carcinoma who underwent external radiotherapy and superselective intra-arterial chemotherapy at Juntendo Hospital. Reassessment of pretreatment images revealed potential Rp metastases in 10 patients （18％）; 9 who were diagnosed with a minor axis of ≥ 5 mm and 1 diagnosed with a major axis of ≥ 10 mm. Patients who underwent MRI or PET-CT tended to have a high rate of Rp node metastases （P ＝ 0.090）. The median irradiation dose for Rp metastasis was 57.7 Gy, and 8/10 patients were irradiated with high doses without targeting. As a result, no recurrence of Rp metastasis was observed. When the Rp region is not targeted during intensity-modulated radiation therapy, the Rp region dose is significantly lower than that of three-dimensional radiation therapy （47.4 Gy vs. 36.0 Gy, respectively; p ＝ 0.040）.
{"title":"Potential retropharyngeal lymph node metastasis on diagnostic image and changes in retropharyngeal regional dose depending on the irradiation technique in maxillary sinus cancer","authors":"Y. Kosugi, T. Kawamoto, M. Oshima, Michimasa Suzuki, M. Fujimaki, S. Ohba, F. Matsumoto, N. Shikama, K. Sasai","doi":"10.5981/JJHNC.47.47","DOIUrl":"https://doi.org/10.5981/JJHNC.47.47","url":null,"abstract":"We retrospectively analyzed the frequency of retropharyngeal lymph node （Rp） metastasis on diagnostic images and the irradiation dose to the same area in 55 patients with advanced maxillary sinus squamous cell carcinoma who underwent external radiotherapy and superselective intra-arterial chemotherapy at Juntendo Hospital. Reassessment of pretreatment images revealed potential Rp metastases in 10 patients （18％）; 9 who were diagnosed with a minor axis of ≥ 5 mm and 1 diagnosed with a major axis of ≥ 10 mm. Patients who underwent MRI or PET-CT tended to have a high rate of Rp node metastases （P ＝ 0.090）. The median irradiation dose for Rp metastasis was 57.7 Gy, and 8/10 patients were irradiated with high doses without targeting. As a result, no recurrence of Rp metastasis was observed. When the Rp region is not targeted during intensity-modulated radiation therapy, the Rp region dose is significantly lower than that of three-dimensional radiation therapy （47.4 Gy vs. 36.0 Gy, respectively; p ＝ 0.040）.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
of the transferred free jejunum due to temporary obstruction of the vascular anastomosis site: Total pharyngolaryngoesophagectomy （TPLE） is performed on patients with advanced head and neck cancer. It is most frequently followed by pharyngoesophageal reconstruction with free jejunal flap because there is a relatively low operative risk and it improves postoperative function of the reconstructed pharynx and esophagus. A 79-year-old man developed hypopharyngeal carcinoma and underwent TPLE, neck dissection on both sides, and free jejunal transfer at our hospital. Early after surgery, we conducted thrombectomy because obstruction by the artery anastomotic region occurred. Blood flow was improved by early thrombectomy, and the flap sur-vived. However, a scarring stenosis which gradually reached full length occurred, and so we performed free jejunal transfer again. The pathological findings indicated that the mucosa had atrophied and been lost, while blood vessels were preserved. Even if the free jejunal flap survives early reoperation for vascular problems after TPLE, it may gradually develop scarring and stenosis.
{"title":"A case of scarring stenosis of the transferred free jejunum due to temporary obstruction of the vascular anastomosis site","authors":"Ryotaro Nakazawa, K. Akashi, S. Kishimoto","doi":"10.5981/jjhnc.47.348","DOIUrl":"https://doi.org/10.5981/jjhnc.47.348","url":null,"abstract":"of the transferred free jejunum due to temporary obstruction of the vascular anastomosis site: Total pharyngolaryngoesophagectomy （TPLE） is performed on patients with advanced head and neck cancer. It is most frequently followed by pharyngoesophageal reconstruction with free jejunal flap because there is a relatively low operative risk and it improves postoperative function of the reconstructed pharynx and esophagus. A 79-year-old man developed hypopharyngeal carcinoma and underwent TPLE, neck dissection on both sides, and free jejunal transfer at our hospital. Early after surgery, we conducted thrombectomy because obstruction by the artery anastomotic region occurred. Blood flow was improved by early thrombectomy, and the flap sur-vived. However, a scarring stenosis which gradually reached full length occurred, and so we performed free jejunal transfer again. The pathological findings indicated that the mucosa had atrophied and been lost, while blood vessels were preserved. Even if the free jejunal flap survives early reoperation for vascular problems after TPLE, it may gradually develop scarring and stenosis.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naoki Akisada, N. Monden, Jiro Aoi, Y. Hayashi, Saori Takahashi, Masataka Nakamura
A radiation-induced malignant tumor is a malignant tumor that develops at the irradiation site after radiation therapy. The latent period is long and the actual situation has not been fully clarified. Intensity-modulated radiation therapy （IMRT）, which has been on the increase in recent years, exposes many normal tissues to radiation. Therefore, by using IMRT, it is estimated that the incidence of radiation-induced malignant tumors is twice as high as that in the past. Although the case we experienced was not caused by IMRT but by con-ventional radiation therapy, it is highly possible that radiation-induced malignant tumors will increase due to the increasing number of IMRT cases and increasing use of chemoradiotherapy. It is essential to review the frequency and end time of follow-up and to establish close cooperation with regional medical institutions.
{"title":"A case of radiation-induced malignant tumor in the head and neck area","authors":"Naoki Akisada, N. Monden, Jiro Aoi, Y. Hayashi, Saori Takahashi, Masataka Nakamura","doi":"10.5981/JJHNC.47.83","DOIUrl":"https://doi.org/10.5981/JJHNC.47.83","url":null,"abstract":"A radiation-induced malignant tumor is a malignant tumor that develops at the irradiation site after radiation therapy. The latent period is long and the actual situation has not been fully clarified. Intensity-modulated radiation therapy （IMRT）, which has been on the increase in recent years, exposes many normal tissues to radiation. Therefore, by using IMRT, it is estimated that the incidence of radiation-induced malignant tumors is twice as high as that in the past. Although the case we experienced was not caused by IMRT but by con-ventional radiation therapy, it is highly possible that radiation-induced malignant tumors will increase due to the increasing number of IMRT cases and increasing use of chemoradiotherapy. It is essential to review the frequency and end time of follow-up and to establish close cooperation with regional medical institutions.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Hirata, Tomohito Fuke, Mamika Kaneko, Daisuke Kobayashi, Hiroyuki Yamada
Diffuse sclerosing variant of papillary thyroid carcinoma is a rare variant. This variant is characterized by diffuse fibrosis, calcification, abundant lymphocytic infiltration and psammoma bodies. This variant is usually seen in female patients in the second decade and has an associated chronic thyroiditis. The sonographic findings of diffuse involvement without an obvious mass in the thyroid make it often misdiagnosed as chronic thyroiditis. The treatment is total thyroidectomy, which is similar to high-risk papillary cancer, but since there are many cases with lymph node metastasis in the lateral neck, modified neck dissection is often performed. Here, we performed total thyroidectomy and modified neck dissection in two young women and added radioiodine isotope therapy postoperatively. Although the observation period was short, no recurrence was observed in either case.
{"title":"Diffuse sclerosing variant of papillary thyroid carcinoma","authors":"T. Hirata, Tomohito Fuke, Mamika Kaneko, Daisuke Kobayashi, Hiroyuki Yamada","doi":"10.5981/jjhnc.47.382","DOIUrl":"https://doi.org/10.5981/jjhnc.47.382","url":null,"abstract":"Diffuse sclerosing variant of papillary thyroid carcinoma is a rare variant. This variant is characterized by diffuse fibrosis, calcification, abundant lymphocytic infiltration and psammoma bodies. This variant is usually seen in female patients in the second decade and has an associated chronic thyroiditis. The sonographic findings of diffuse involvement without an obvious mass in the thyroid make it often misdiagnosed as chronic thyroiditis. The treatment is total thyroidectomy, which is similar to high-risk papillary cancer, but since there are many cases with lymph node metastasis in the lateral neck, modified neck dissection is often performed. Here, we performed total thyroidectomy and modified neck dissection in two young women and added radioiodine isotope therapy postoperatively. Although the observation period was short, no recurrence was observed in either case.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case report of oropharyngeal clear cell carcinoma with revised pathological diagnosis after multi-gene cancer panel testing","authors":"Keiichi Koshizuka, K. Yamasaki, T. Kinoshita, T. Iinuma, S. Yonekura, T. Hanazawa","doi":"10.5981/jjhnc.47.342","DOIUrl":"https://doi.org/10.5981/jjhnc.47.342","url":null,"abstract":"要 旨 標準治療が終了となった肺転移を伴う中咽頭癌患者に対して,がん遺伝子パネル検査を行った結果,扁平上 皮癌から明細胞癌に病理学的診断が修正された患者を経験したので報告する。症例は 57 歳,女性,中咽頭扁 平上皮癌,HPV 陰性,cT3N2bMX。シスプラチン併用放射線治療を施行したが,肺転移を疑っていた病変が 増大した。ニボルマブ投与を行ったが,肺転移は更に増大し,セツキシマブ+パクリタキセル投与を開始し た。その後,標準治療終了後の固形がんとしてがん遺伝子パネル検査を行った。治療対象となる遺伝子異常は 認められなかったが,EWSR1-ATF1 融合遺伝子が検出された。この遺伝子は唾液腺明細胞癌の 80 ~ 90%の 症例に検出される。この結果から,病理診断が扁平上皮癌から明細胞癌に修正された。後方視的に組織を確認 しても,明細胞癌の診断は困難であり,がん遺伝子パネル検査が診断修正の契機となった症例であった。","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomoya Ishida, Akimichi Minesaki, Eriko Shimazaki, M. Yamauchi, Rintaro Shimazu, Y. Kuratomi
tumor invasion potential: pT re-classification according to the UICC, 8th edition and evaluation of tumor invasion potential by the Yama-moto-Kohama （YK） classification were performed for 45 patients with pT1, 2N0 oral tongue cancers （UICC, 7th edition） who had undergone surgical resection as initial treatment followed by observation. Association between the two factors and late cervical metastases and survival rates were analyzed. The number of patients with pT1/2/3 （UICC, 8th edition） and YK-1, 2/3/4C, 4D was 17/20/8 and 10/18/17, respectively. The late cervical metastasis rate and 5-year disease-specific survival rate for pT1/2/3 were 29/45/63％ and 88/85/63％, and for YK-1, 2/3/4C, 4D were 10/39/65％ and 100/100/53％, respectively. Tumor invasion potential was more strongly associated with prognosis than pT classification （8th edition）. All of the low to moderately invasive YK-1-3 tumors were controlled by neck dissection after the appearance of late cervical metastasis, and therefore, the observation strategy seems to be appropriate for these tumors. In contrast, the highly invasive YK-4C, 4D tumors presented poor control rates by the observation strategy, and therefore, might need more intensive treatments such as additional neck dissection following primary tumor resection before late cervical metastasis appears.
{"title":"Strategy of neck dissection for early tongue cancer based on tumor invasion potential","authors":"Tomoya Ishida, Akimichi Minesaki, Eriko Shimazaki, M. Yamauchi, Rintaro Shimazu, Y. Kuratomi","doi":"10.5981/jjhnc.47.295","DOIUrl":"https://doi.org/10.5981/jjhnc.47.295","url":null,"abstract":"tumor invasion potential: pT re-classification according to the UICC, 8th edition and evaluation of tumor invasion potential by the Yama-moto-Kohama （YK） classification were performed for 45 patients with pT1, 2N0 oral tongue cancers （UICC, 7th edition） who had undergone surgical resection as initial treatment followed by observation. Association between the two factors and late cervical metastases and survival rates were analyzed. The number of patients with pT1/2/3 （UICC, 8th edition） and YK-1, 2/3/4C, 4D was 17/20/8 and 10/18/17, respectively. The late cervical metastasis rate and 5-year disease-specific survival rate for pT1/2/3 were 29/45/63％ and 88/85/63％, and for YK-1, 2/3/4C, 4D were 10/39/65％ and 100/100/53％, respectively. Tumor invasion potential was more strongly associated with prognosis than pT classification （8th edition）. All of the low to moderately invasive YK-1-3 tumors were controlled by neck dissection after the appearance of late cervical metastasis, and therefore, the observation strategy seems to be appropriate for these tumors. In contrast, the highly invasive YK-4C, 4D tumors presented poor control rates by the observation strategy, and therefore, might need more intensive treatments such as additional neck dissection following primary tumor resection before late cervical metastasis appears.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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