Miki Takahashi, S. Iwaki, Keisuke Iritani, Shun Tatehara, T. Furukawa, M. Teshima, H. Shinomiya, K. Nibu
{"title":"The importance of speech therapists （ST） intervention for voice rehabilitation and management of tracheostoma after total laryngectomy","authors":"Miki Takahashi, S. Iwaki, Keisuke Iritani, Shun Tatehara, T. Furukawa, M. Teshima, H. Shinomiya, K. Nibu","doi":"10.5981/jjhnc.47.322","DOIUrl":"https://doi.org/10.5981/jjhnc.47.322","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is recommended that elderly cancer patients should be evaluated for geriatric assessment. This study in-vestigated the diagnostic characteristics of two geriatric screening tools, G8 （Geriatric 8） and fTRST （Flemish version of Triage Risk Screening Tool）, in older patients with head and neck cancer and the prognostic value of these screening tools for overall survival, treatment completion and complications. The subjects were 30 patients over 70 years old who were evaluated by G8 and fTRST between March 2017 and October 2019. A Cox regression analysis with G8 and fTRST as the independent variables was conducted for the OS analysis. Univariate analysis showed that only G8, in which we set the cut-off value to 14, was a statistically significant prognostic predictor （hazard ratio 9.64, p ＝ 0.036）. G8 was considered to be a more useful screening tool in predicting the prognosis of elderly patients with head and neck cancer.
建议对老年癌症患者进行老年评估。本研究探讨了两种老年筛查工具G8 (geriatric 8)和fTRST (Flemish version of Triage Risk screening Tool)在老年头颈癌患者中的诊断特点，以及这些筛查工具对总生存期、治疗完成度和并发症的预后价值。研究对象为30例70岁以上的患者，于2017年3月至2019年10月期间通过G8和fTRST进行评估。采用以G8和fTRST为自变量的Cox回归分析进行OS分析。单因素分析显示，只有我们设定临界值为14的G8是具有统计学意义的预后预测因子(风险比9.64,p = 0.036)。G8被认为是预测老年头颈癌患者预后更有用的筛查工具。
{"title":"Prognostic value of geriatric screening tools in elderly patients with head and neck cancer","authors":"Teppei Kaminota, H. Aritomo, Yusuke Shinomori","doi":"10.5981/jjhnc.47.376","DOIUrl":"https://doi.org/10.5981/jjhnc.47.376","url":null,"abstract":"It is recommended that elderly cancer patients should be evaluated for geriatric assessment. This study in-vestigated the diagnostic characteristics of two geriatric screening tools, G8 （Geriatric 8） and fTRST （Flemish version of Triage Risk Screening Tool）, in older patients with head and neck cancer and the prognostic value of these screening tools for overall survival, treatment completion and complications. The subjects were 30 patients over 70 years old who were evaluated by G8 and fTRST between March 2017 and October 2019. A Cox regression analysis with G8 and fTRST as the independent variables was conducted for the OS analysis. Univariate analysis showed that only G8, in which we set the cut-off value to 14, was a statistically significant prognostic predictor （hazard ratio 9.64, p ＝ 0.036）. G8 was considered to be a more useful screening tool in predicting the prognosis of elderly patients with head and neck cancer.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mami Yasumoto, S. Shinohara, S. Takebayashi, Kiyomi Hamaguchi, Tetsuhiko Michida, Tadashi Ikenaga, Yota Tobe, Ayami Hamamoto
{"title":"Total excision for the diagnosis of lingual leukoplakia: How do we set a surgical margin for safety excision?","authors":"Mami Yasumoto, S. Shinohara, S. Takebayashi, Kiyomi Hamaguchi, Tetsuhiko Michida, Tadashi Ikenaga, Yota Tobe, Ayami Hamamoto","doi":"10.5981/jjhnc.47.311","DOIUrl":"https://doi.org/10.5981/jjhnc.47.311","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katsushige Kawase, Keiichi Koshizuka, Riyo Yoneda, K. Yamasaki, S. Yonekura, T. Hanazawa
{"title":"A study of 44 cases of recurrent or metastatic head and neck cancer treated with nivolumab","authors":"Katsushige Kawase, Keiichi Koshizuka, Riyo Yoneda, K. Yamasaki, S. Yonekura, T. Hanazawa","doi":"10.5981/jjhnc.47.284","DOIUrl":"https://doi.org/10.5981/jjhnc.47.284","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two cases of synovial sarcoma in the Adolescent and Young Adult （AYA） generation","authors":"Megumi Mogi, H. Chazono, Keiichi Koshizuka, T. Kinoshita, K. Yamasaki, N. Kikkawa, T. Hanazawa","doi":"10.5981/jjhnc.47.400","DOIUrl":"https://doi.org/10.5981/jjhnc.47.400","url":null,"abstract":"要 旨 思春期・若年成人(AYA)世代の頭頸部悪性腫瘍手術では機能温存が重要である。AYA 世代の頭頸部原 発滑膜肉腫の 2 症例を報告する。【症例 1】18 歳男性。CT で下咽頭輪状後部を基部とする長径 135mm の腫 瘤を認めた。生検で悪性が疑われ,喉頭温存し下咽頭腫瘍切除術,両頸部郭清術,遊離空腸再建術を施行し た。術後滑膜肉腫の診断で補助化学療法を施行したが,頸部再発と肺転移のため術後 3 年半で原病死した。 【症例 2】15 歳女性。CT で右副咽頭間隙に長径 95mm の腫瘤を認めた。右内頸動脈との癒着を伴う傍神経腫 が疑われ腫瘍摘出術を施行した。右内頸動脈は温存した。術後滑膜肉腫の診断で補助化学療法を施行したが, 頭蓋底再発,骨転移および髄膜播種のため術後 5 年半で原病死した。滑膜肉腫の治療の第一選択は手術だが, 上記 2 症例ではより広い安全域の必要性が示唆された。AYA 世代での術式の選択は難しく今後の症例の蓄積 が望まれる。","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preserving cervical vessels and surgical margins in good condition enables reconstructive surgeons （not only plastic surgeons but all members of the team） to perform safe and reliable reconstruction.
{"title":"Points of free jejunal flap transfer with multiple vascular pedicles in hypopharyngeal reconstruction","authors":"T. Kurita","doi":"10.5981/jjhnc.46.317","DOIUrl":"https://doi.org/10.5981/jjhnc.46.317","url":null,"abstract":"Preserving cervical vessels and surgical margins in good condition enables reconstructive surgeons （not only plastic surgeons but all members of the team） to perform safe and reliable reconstruction.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nivolumab was approved for platinum refractory recurrent and metastatic head and neck carcinoma in 2017. Pembrolizumab as first-line treatment for recurrent and metastatic head and neck carcinoma was reported in 2019 and it is predicted that the first-line treatment will change. Many immune-related adverse events were reported by immune checkpoint inhibitors. Therefore, we should start administering steroid to control inflam-mation and severe IrAE. In addition, some patients should be put on steroid for a long time because of anti-inflammation. Furthermore, when cisplatin, which is one of the key drugs for head and neck cancer, is adminis-tered, steroid can prevent delayed nausea. Here, we review the important points and observations on the use of steroid against irAE.
{"title":"The knowledge and management of steroid side effects for head and neck cancer oncology treatment physician","authors":"T. Yamazaki","doi":"10.5981/jjhnc.46.26","DOIUrl":"https://doi.org/10.5981/jjhnc.46.26","url":null,"abstract":"Nivolumab was approved for platinum refractory recurrent and metastatic head and neck carcinoma in 2017. Pembrolizumab as first-line treatment for recurrent and metastatic head and neck carcinoma was reported in 2019 and it is predicted that the first-line treatment will change. Many immune-related adverse events were reported by immune checkpoint inhibitors. Therefore, we should start administering steroid to control inflam-mation and severe IrAE. In addition, some patients should be put on steroid for a long time because of anti-inflammation. Furthermore, when cisplatin, which is one of the key drugs for head and neck cancer, is adminis-tered, steroid can prevent delayed nausea. Here, we review the important points and observations on the use of steroid against irAE.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.1007/978-3-030-27881-6_12
Y. Kram, Eric D. Wirtz
{"title":"Multidisciplinary Care","authors":"Y. Kram, Eric D. Wirtz","doi":"10.1007/978-3-030-27881-6_12","DOIUrl":"https://doi.org/10.1007/978-3-030-27881-6_12","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"53 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90675670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of prosthetic devices for reduction of mechanical irritation that induces tongue cancers","authors":"R. Aijima, A. Danjo, Y. Yamashita","doi":"10.5981/jjhnc.46.378","DOIUrl":"https://doi.org/10.5981/jjhnc.46.378","url":null,"abstract":"要 旨 舌縁部は舌がんの好発部位であり,がん発症の誘因として不適合な補綴装置,歯の傾斜などの歯列不正によ る慢性的な機械刺激があげられる。また歯列不正がない場合でも,歯列弓と舌の大きさの不調和により,舌縁 部へ持続的な刺激が加わることも舌がん発症の誘因となりうる。歯列不正や舌房が狭いことで口腔粘膜への機 械刺激が持続する患者には,矯正歯科治療は有効と考えられるが,年齢や経済的問題からすべての症例に適応 とはならない。今回,舌縁部に発生したがんの一次治療後に,持続する機械刺激が疑われる 3 症例に対して, 刺激軽減を目的とした補綴装置を作製した。本補綴装置を使用することにより,全例ともに局所への刺激が軽 減され,再発防止に繋がる可能性が示唆された。本補綴装置の使用は簡易で可逆的であり,機械刺激に対する 新しい対処法として有用であると考える。ただし,装置の未使用で容易に症状が再燃することから,十分な患 者教育が必要である。","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71242785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Matsuo, R. Uchi, Masahiko Taura, T. Wakasaki, R. Yasumatsu, Takashi Nakagawa
Distant metastasis occurs occasionally in differentiated thyroid cancer patients, with the lungs and bones being the most frequent locations. An extremely rare location of distant metastasis is the pancreas, as reported in only 16 published cases. In this article we report a case with pancreatic metastases from thyroid papillary carcinoma. A 71-year-old woman underwent total thyroidectomy for thyroid papillary carcinoma with lung metastases. While the patient was undergoing TSH suppression therapy, the thyroid cancer spread to the pancreas. She began receiving Lenvatinib, a molecular-targeted drug, which was very effective, and the lung and pancreatic metastases diminished during 15 months. In rare cases like pancreatic metastasis from differentiated thyroid cancer, the standard of care is unclear. If the case has a condition that cannot be removed with surgery, or cannot be treated by RAI therapy, we believe that molecular-targeted drugs might be a good treatment as one of the choices.
{"title":"Pancreatic metastasis from differentiated thyroid cancer : a case report","authors":"M. Matsuo, R. Uchi, Masahiko Taura, T. Wakasaki, R. Yasumatsu, Takashi Nakagawa","doi":"10.5981/jjhnc.46.385","DOIUrl":"https://doi.org/10.5981/jjhnc.46.385","url":null,"abstract":"Distant metastasis occurs occasionally in differentiated thyroid cancer patients, with the lungs and bones being the most frequent locations. An extremely rare location of distant metastasis is the pancreas, as reported in only 16 published cases. In this article we report a case with pancreatic metastases from thyroid papillary carcinoma. A 71-year-old woman underwent total thyroidectomy for thyroid papillary carcinoma with lung metastases. While the patient was undergoing TSH suppression therapy, the thyroid cancer spread to the pancreas. She began receiving Lenvatinib, a molecular-targeted drug, which was very effective, and the lung and pancreatic metastases diminished during 15 months. In rare cases like pancreatic metastasis from differentiated thyroid cancer, the standard of care is unclear. If the case has a condition that cannot be removed with surgery, or cannot be treated by RAI therapy, we believe that molecular-targeted drugs might be a good treatment as one of the choices.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71242797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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