Saori Takahashi, N. Monden, Jiro Aoi, Naoki Akisada, Y. Hayashi, S. Morita, Masataka Nakamura
{"title":"Four cases of adult alveolar rhabdomyosarcoma in the head and neck area","authors":"Saori Takahashi, N. Monden, Jiro Aoi, Naoki Akisada, Y. Hayashi, S. Morita, Masataka Nakamura","doi":"10.5981/jjhnc.48.330","DOIUrl":"https://doi.org/10.5981/jjhnc.48.330","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Yasuda, M. Ōsaki, M. Hara, S. Kinoshita, Kazuhiro Mitsumura, K. Kuba, Keitaro Nagano, Rei Sugihara, Ryouhei Mukae, Akio Hatanaka, W. Nishijima, Eikichi Tokunaga, M. Shimoda, T. Hashimoto, Sanae Bandou, Yusuke Yamamoto, Hideki Fujiwara
gested epithelial-myoepithelial carcinoma that had undergone high-grade transformation.
胚胎上皮-肌上皮癌经历了高级别转化。
{"title":"A case of suspected epithelial myoepithelial carcinoma in the parotid gland with high-grade transformation in which an HRAS mutation was detected","authors":"T. Yasuda, M. Ōsaki, M. Hara, S. Kinoshita, Kazuhiro Mitsumura, K. Kuba, Keitaro Nagano, Rei Sugihara, Ryouhei Mukae, Akio Hatanaka, W. Nishijima, Eikichi Tokunaga, M. Shimoda, T. Hashimoto, Sanae Bandou, Yusuke Yamamoto, Hideki Fujiwara","doi":"10.5981/jjhnc.48.34","DOIUrl":"https://doi.org/10.5981/jjhnc.48.34","url":null,"abstract":"gested epithelial-myoepithelial carcinoma that had undergone high-grade transformation.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yukiko Ito, K. Honda, Shinpei Kada, M. Miyazaki, R. Asato
A case of myxofibrosarcoma in the neck treated with postoperative radiation therapy : Yukiko Ito1), Keigo Honda2), Shinpei Kada3), Masakazu Miyazaki4) and Ryo Asato1) 1) Department of Head and Neck Surgery, National Hospital Organization Kyoto Medical Center 2) Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University 3) Department of Otolaryngology-Head and Neck Surgery, Japanese Red Cross Society 4) Department of Head and Neck Surgery, Nara Prefecture General Medical Center
{"title":"A case of myxofibrosarcoma in the neck treated with postoperative radiation therapy","authors":"Yukiko Ito, K. Honda, Shinpei Kada, M. Miyazaki, R. Asato","doi":"10.5981/jjhnc.48.291","DOIUrl":"https://doi.org/10.5981/jjhnc.48.291","url":null,"abstract":"A case of myxofibrosarcoma in the neck treated with postoperative radiation therapy : Yukiko Ito1), Keigo Honda2), Shinpei Kada3), Masakazu Miyazaki4) and Ryo Asato1) 1) Department of Head and Neck Surgery, National Hospital Organization Kyoto Medical Center 2) Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University 3) Department of Otolaryngology-Head and Neck Surgery, Japanese Red Cross Society 4) Department of Head and Neck Surgery, Nara Prefecture General Medical Center","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miyuki Tani, T. Sugimoto, Norio Kondo, Yuki Suzuki
{"title":"Two cases with pneumatosis intestinalis and portal venous gas which occurred after chemoradiotherapy for hypopharyngeal cancer","authors":"Miyuki Tani, T. Sugimoto, Norio Kondo, Yuki Suzuki","doi":"10.5981/jjhnc.48.338","DOIUrl":"https://doi.org/10.5981/jjhnc.48.338","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keitaro Fujii, T. Imai, Yuya Miyakura, Kohsei Hasegawa, Akira Nakazato, Shinkichi Morita, Satoshi Saijyo, Y. Asada
subsequent to hypothyroidism: A 60-year-old man was treated with pembrolizumab for recurrence of lung metastasis after surgery for hy-popharyngeal carcinoma. Three months after the first dose, severe hypothyroidism was observed. This was thought to be an immune-related adverse event （irAE） and treatment was temporarily discontinued. Levothy-roxine was started, thyroid function recovered, and pembrolizumab was restarted. Seven months after the first dose, general malaise and anorexia were observed. On the basis of the decrease in serum ACTH and cortisol levels, we diagnosed hypopituitarism as an irAE. Hydrocortisone was administered and the general condition promptly improved. Hypothyroidism induced by immune checkpoint inhibitors is a frequently observed irAE and may be secondary to hypopituitarism, as in this case.
{"title":"A case of pembrolizumab-induced hypopituitarism subsequent to hypothyroidism","authors":"Keitaro Fujii, T. Imai, Yuya Miyakura, Kohsei Hasegawa, Akira Nakazato, Shinkichi Morita, Satoshi Saijyo, Y. Asada","doi":"10.5981/jjhnc.48.295","DOIUrl":"https://doi.org/10.5981/jjhnc.48.295","url":null,"abstract":"subsequent to hypothyroidism: A 60-year-old man was treated with pembrolizumab for recurrence of lung metastasis after surgery for hy-popharyngeal carcinoma. Three months after the first dose, severe hypothyroidism was observed. This was thought to be an immune-related adverse event （irAE） and treatment was temporarily discontinued. Levothy-roxine was started, thyroid function recovered, and pembrolizumab was restarted. Seven months after the first dose, general malaise and anorexia were observed. On the basis of the decrease in serum ACTH and cortisol levels, we diagnosed hypopituitarism as an irAE. Hydrocortisone was administered and the general condition promptly improved. Hypothyroidism induced by immune checkpoint inhibitors is a frequently observed irAE and may be secondary to hypopituitarism, as in this case.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenshi Iwanaga, A. Suehiro, Shin-ichi Sato, H. Tamaki, Koichi Omori
Although multidisciplinary treatment, including resective and reconstructive surgery, should be considered for the management of advanced oropharyngeal cancer, severe postoperative dysphagia may occur, and laryngeal preservation may be difficult. Oropharyngeal carcinoma of the posterior wall is rare and has a poorer postoperative swallowing function and prognosis than that of other subsites, but detailed reports on swallowing dynamics are limited. Here, we report the case of a 76-year-old man. He underwent resection of the oropharynx, neck dissection, cricopharyngeal myotomy for oropharyngeal posterior wall carcinoma, and reconstruction with an anterolateral thigh flap. After surgery, the patient presented severe dysphagia but recovered the ability to swallow food that required mastication in approximately 2 months, and was discharged home. After approximately 4.5 years post-surgery, he remains able to consume regular food without showing any recurrence. We believe that preservation of most of the suprahyoid muscle group and cricopharyngeal myotomy were factors for maintaining swallowing function. In addition, by focusing on functional compensation, including postoperative rehabilitation, laryngeal preservation is suggested to help patients with oropharyngeal posterior wall cancer.
{"title":"A case report of swallowing function in a patient who resumed oral intake after reconstructive surgery for oropharyngeal cancer of the posterior wall","authors":"Kenshi Iwanaga, A. Suehiro, Shin-ichi Sato, H. Tamaki, Koichi Omori","doi":"10.5981/jjhnc.48.301","DOIUrl":"https://doi.org/10.5981/jjhnc.48.301","url":null,"abstract":"Although multidisciplinary treatment, including resective and reconstructive surgery, should be considered for the management of advanced oropharyngeal cancer, severe postoperative dysphagia may occur, and laryngeal preservation may be difficult. Oropharyngeal carcinoma of the posterior wall is rare and has a poorer postoperative swallowing function and prognosis than that of other subsites, but detailed reports on swallowing dynamics are limited. Here, we report the case of a 76-year-old man. He underwent resection of the oropharynx, neck dissection, cricopharyngeal myotomy for oropharyngeal posterior wall carcinoma, and reconstruction with an anterolateral thigh flap. After surgery, the patient presented severe dysphagia but recovered the ability to swallow food that required mastication in approximately 2 months, and was discharged home. After approximately 4.5 years post-surgery, he remains able to consume regular food without showing any recurrence. We believe that preservation of most of the suprahyoid muscle group and cricopharyngeal myotomy were factors for maintaining swallowing function. In addition, by focusing on functional compensation, including postoperative rehabilitation, laryngeal preservation is suggested to help patients with oropharyngeal posterior wall cancer.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three cases of skull base osteoradionecrosis","authors":"Takashi Kitani, Sohei Mitani, Eriko Sato, N. Hato","doi":"10.5981/jjhnc.48.323","DOIUrl":"https://doi.org/10.5981/jjhnc.48.323","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masao Hashidume, H. Kurita, Kiriko Kubo, E. Kondo, H. Sakai, S. Yamada
Examination of late stage elderly patients with oral cancer who were classified as prefrail （vulnerable）: We examined 23 prefrail （vulnerable） patients among patients with late-stage elderly oral cancer treated in our department. The 5-year overall survival rate was 41.9%, and when classified according to treatment approach, the survival rate was higher in the group that received absolute curative treatment （standard treatment）. Uni-variate analysis of each factor affecting prognosis showed significant differences in G8 score （p=0.047） and stage （p=0.022）, and treatment approach （p=0.052） also tended to affect prognosis. In the results of multivariate analysis, only therapeutic approach was extracted as a factor that significantly affected prognosis （p=0.034）. In addition, decision tree analysis showed that the G8 score was divided into 14 points or more and less than 14 points, suggesting that it may be a predictor of prognosis. Prefrail （vulnerable） is a conceptual category in which it is difficult to apply standard treatment, but it is thought that aiming for standard treatment without easily reducing the treatment intensity will lead to improvement in prognosis. In addition, it is considered useful to use the G8 screening tool as a patient evaluation method.
{"title":"Examination of late stage elderly patients with oral cancer who were classified as prefrail （vulnerable）","authors":"Masao Hashidume, H. Kurita, Kiriko Kubo, E. Kondo, H. Sakai, S. Yamada","doi":"10.5981/jjhnc.48.28","DOIUrl":"https://doi.org/10.5981/jjhnc.48.28","url":null,"abstract":"Examination of late stage elderly patients with oral cancer who were classified as prefrail （vulnerable）: We examined 23 prefrail （vulnerable） patients among patients with late-stage elderly oral cancer treated in our department. The 5-year overall survival rate was 41.9%, and when classified according to treatment approach, the survival rate was higher in the group that received absolute curative treatment （standard treatment）. Uni-variate analysis of each factor affecting prognosis showed significant differences in G8 score （p=0.047） and stage （p=0.022）, and treatment approach （p=0.052） also tended to affect prognosis. In the results of multivariate analysis, only therapeutic approach was extracted as a factor that significantly affected prognosis （p=0.034）. In addition, decision tree analysis showed that the G8 score was divided into 14 points or more and less than 14 points, suggesting that it may be a predictor of prognosis. Prefrail （vulnerable） is a conceptual category in which it is difficult to apply standard treatment, but it is thought that aiming for standard treatment without easily reducing the treatment intensity will lead to improvement in prognosis. In addition, it is considered useful to use the G8 screening tool as a patient evaluation method.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71244090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayano Kondo-Matsumura, D. Kawakita, T. Matoba, Gaku Takano, Keisuke Oguri, Akihiro Murashima, K. Minohara, Kazuyuki Nakai, Sho Iwaki, H. Tsuge, Koji Tsukamoto, Wataru Hojo, Shin-ichi Iwasaki
She was diagnosed with squamous cell carcinoma of the tongue （cT4aN3bM1: lung metastasis）. Due to poor performance status, best supportive care was selected. Because of concerns about metachronal and multiple recurrence after surgery in patients with chronic oral GVHD, long-term follow-up should be considered.
{"title":"Two cases of chronic GVHD-related tongue cancer","authors":"Ayano Kondo-Matsumura, D. Kawakita, T. Matoba, Gaku Takano, Keisuke Oguri, Akihiro Murashima, K. Minohara, Kazuyuki Nakai, Sho Iwaki, H. Tsuge, Koji Tsukamoto, Wataru Hojo, Shin-ichi Iwasaki","doi":"10.5981/jjhnc.48.286","DOIUrl":"https://doi.org/10.5981/jjhnc.48.286","url":null,"abstract":"She was diagnosed with squamous cell carcinoma of the tongue （cT4aN3bM1: lung metastasis）. Due to poor performance status, best supportive care was selected. Because of concerns about metachronal and multiple recurrence after surgery in patients with chronic oral GVHD, long-term follow-up should be considered.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuta Yamamura, Y. Horichi, H. Matsui, S. Iwae, T. Okimoto, Y. Demizu
{"title":"Current status of particle cancer board","authors":"Yuta Yamamura, Y. Horichi, H. Matsui, S. Iwae, T. Okimoto, Y. Demizu","doi":"10.5981/jjhnc.48.319","DOIUrl":"https://doi.org/10.5981/jjhnc.48.319","url":null,"abstract":"","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71243911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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