Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-7-10
V. Abakumets, K. Bulanava
Violation of protein folding leads to the development of a number of systemic and neurodegenerative diseases-proteinopathy. In these pathologies, proteins acquire an incorrect conformation that differs from the native one, become functionally inactive, toxic, and prone to aggregation and deposition in various organs and tissues. There is a widespread hypothesis that the primary cytotoxic agents in the development of proteinopathies are protein oligomers that are prone to aggregation. These diseases include Parkinson’s disease, Creutzfeldt-Jakob disease, type 2 diabetes, and many others.
{"title":"THE INFLUENCE OF INSULIN FIBRILLATION","authors":"V. Abakumets, K. Bulanava","doi":"10.46646/sakh-2021-2-7-10","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-7-10","url":null,"abstract":"Violation of protein folding leads to the development of a number of systemic and neurodegenerative diseases-proteinopathy. In these pathologies, proteins acquire an incorrect conformation that differs from the native one, become functionally inactive, toxic, and prone to aggregation and deposition in various organs and tissues. There is a widespread hypothesis that the primary cytotoxic agents in the development of proteinopathies are protein oligomers that are prone to aggregation. These diseases include Parkinson’s disease, Creutzfeldt-Jakob disease, type 2 diabetes, and many others.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132124314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-55-58
P. T. Zhurko, I. Koktysh, R. Smolyakova
The circulating microRNAs (let-7e and miR-140) expression levels were studied in the plasma of peripheral blood and synovial fluid of patients with gonarthrosis and coxarthrosis. There was a statistically significant decrease in the expression of miR-140 in synovial fluid and let-7e in the peripheral blood of patients with osteoarthritis (p <0.05). MicroRNA let-7e characterizes comorbidity and indicates the development of metabolic syndrome. It was established a correlation between the microRNAs expression levels and the disease severity.
{"title":"MicroRNA let-7e AND miR-140 AS BIOMARKERS OF DEFORMING JOINT DISEASES","authors":"P. T. Zhurko, I. Koktysh, R. Smolyakova","doi":"10.46646/sakh-2021-2-55-58","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-55-58","url":null,"abstract":"The circulating microRNAs (let-7e and miR-140) expression levels were studied in the plasma of peripheral blood and synovial fluid of patients with gonarthrosis and coxarthrosis. There was a statistically significant decrease in the expression of miR-140 in synovial fluid and let-7e in the peripheral blood of patients with osteoarthritis (p <0.05). MicroRNA let-7e characterizes comorbidity and indicates the development of metabolic syndrome. It was established a correlation between the microRNAs expression levels and the disease severity.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133739073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-209-213
A. N. Savitsky, K. Mukina
The article discusses the environmental management system. Based on the data of the enterprise, an analysis of the protection of atmospheric air, the use of water resources, the management of industrial waste, environmental aspects and a methodology for assessing the importance of environmental aspects were carried out.
{"title":"ANALYSIS OF THE ENVIRONMENTAL MANAGEMENT SYSTEM AT OJSC “BMZ”","authors":"A. N. Savitsky, K. Mukina","doi":"10.46646/sakh-2021-2-209-213","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-209-213","url":null,"abstract":"The article discusses the environmental management system. Based on the data of the enterprise, an analysis of the protection of atmospheric air, the use of water resources, the management of industrial waste, environmental aspects and a methodology for assessing the importance of environmental aspects were carried out.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133485787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-395-398
A. A. Akantinova, U. Ivaniukovich
The structure and functionality of a mobile application designed for accounting and ordering of chemicals used in an enterprise is described. The application allows real-time use of the database created on a specialized site.
{"title":"ORGANIZATION OF THE STORAGE AND USE OF CHEMICALS IN AN ENTERPRISE","authors":"A. A. Akantinova, U. Ivaniukovich","doi":"10.46646/sakh-2021-2-395-398","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-395-398","url":null,"abstract":"The structure and functionality of a mobile application designed for accounting and ordering of chemicals used in an enterprise is described. The application allows real-time use of the database created on a specialized site.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127834858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-245-248
D. Brinkevich, S. Brinkevich, H. Kiyavitskaya, A. Kiyko
The accumulation of secondary radionuclides (PRN) in water [18O]H2O under irradiation on a Cyclone 18/9 HC cyclotron with a niobium target and an entrance window made of Havar alloy was studied. It is shown that the activity of PRN is mainly determined by the accumulated dose of the target. The dominant source of PRN is the entrance window made of Havar alloy. The niobium target is the source of only one radionuclide, 92mNb, whose activity is low. In the process of water activation, radioisotopes 7Be and probably 65Zn are formed. The water [18O] H2O irradiated on the cyclotron is a dispersed system. Up to 30 % of the activity of cobalt and manganese, as well as ~7% of chromium, are in the composition of solid particles >5 microns in size, washed out of the input foil of the cyclotron target due to intergranular corrosion.
{"title":"SOURCES OF GAMMA-EMITTING RADIONUCLIDES IN THE PRODUCTION OF RADIOPHARMACEUTICALS USING ТНЕ CYCLONE 18/9 HC CYCLOTRON","authors":"D. Brinkevich, S. Brinkevich, H. Kiyavitskaya, A. Kiyko","doi":"10.46646/sakh-2021-2-245-248","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-245-248","url":null,"abstract":"The accumulation of secondary radionuclides (PRN) in water [18O]H2O under irradiation on a Cyclone 18/9 HC cyclotron with a niobium target and an entrance window made of Havar alloy was studied. It is shown that the activity of PRN is mainly determined by the accumulated dose of the target. The dominant source of PRN is the entrance window made of Havar alloy. The niobium target is the source of only one radionuclide, 92mNb, whose activity is low. In the process of water activation, radioisotopes 7Be and probably 65Zn are formed. The water [18O] H2O irradiated on the cyclotron is a dispersed system. Up to 30 % of the activity of cobalt and manganese, as well as ~7% of chromium, are in the composition of solid particles >5 microns in size, washed out of the input foil of the cyclotron target due to intergranular corrosion.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131473615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-324-327
A. Khamitsevich, A. Butko, L. A. Lipnitsky
This paper discusses the possibility of fuel saving with deep utilization of flue gases from boilers using fastgrowing woody biomass. It is proposed to use willow as biomass.
本文讨论了利用快速生长的木质生物质深度利用锅炉烟气节约燃料的可能性。建议利用柳树作为生物质。
{"title":"DEEP UTILIZATION OF BOILER’S SMOKE GASES ON WOOD BIOMASS","authors":"A. Khamitsevich, A. Butko, L. A. Lipnitsky","doi":"10.46646/sakh-2021-2-324-327","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-324-327","url":null,"abstract":"This paper discusses the possibility of fuel saving with deep utilization of flue gases from boilers using fastgrowing woody biomass. It is proposed to use willow as biomass.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123673267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-17-20
G. V. Bel’kov, M. Piatkevich
For the correct application of high-tech methods of radiation therapy, it is necessary to use strict requirements for the technical and dosimetric parameters of radiotherapy equipment, the accuracy of adjustment and calibration of its geometric, mechanical and radiation parameters. To determine the values of possible errors in patient positioning during radiation treatment, the authors considered the design and characteristics of typical RTS, developed a model of the patient’s «average» body, which allows changing the load on the TP RTS with a step of 1 kg. The parameters of the TP position were determined for the main types of localizations of radiation therapy for malignant neoplasms. Numerical values of deviations of the radiation beam isocenter from the treatment couch prescribed horizontal position were experimentally established for a load on it from 40 to 180 kg for treatment couch used for patients’ treatments in N.N. Alexandrov National Cancer Centre of Belarus.
{"title":"THE EFFECT OF POSITIONING ACCURACY OF CANCER PATIENTS ON THE PARAMETERS OF THE INDIVIDUAL THREE-DIMENSIONAL DOSE DISTRIBUTION DELIVERED TO THEM","authors":"G. V. Bel’kov, M. Piatkevich","doi":"10.46646/sakh-2021-2-17-20","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-17-20","url":null,"abstract":"For the correct application of high-tech methods of radiation therapy, it is necessary to use strict requirements for the technical and dosimetric parameters of radiotherapy equipment, the accuracy of adjustment and calibration of its geometric, mechanical and radiation parameters. To determine the values of possible errors in patient positioning during radiation treatment, the authors considered the design and characteristics of typical RTS, developed a model of the patient’s «average» body, which allows changing the load on the TP RTS with a step of 1 kg. The parameters of the TP position were determined for the main types of localizations of radiation therapy for malignant neoplasms. Numerical values of deviations of the radiation beam isocenter from the treatment couch prescribed horizontal position were experimentally established for a load on it from 40 to 180 kg for treatment couch used for patients’ treatments in N.N. Alexandrov National Cancer Centre of Belarus.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115775825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-132-135
M. Khancheuski, V. N. Lesik, E. Kvasyuk
This article shows methods for the preparation of 8-bromoadenosine which is an important intermediate in the syntheses of analogs of purines nucleosides and nucleotides with a broad spectrum of biological activity. The influence of the pH values of the medium on the yield of 8-bromoadenosine was studied. It was showed that pH 4.3 is optimal for the preparation of 8-bromoadenosine by reaction of adenosine with a solution of bromine in water.
{"title":"SYNTHESIS OF 8-BROMOADENOSINE AT DIFFERENT PH VALUES","authors":"M. Khancheuski, V. N. Lesik, E. Kvasyuk","doi":"10.46646/sakh-2021-2-132-135","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-132-135","url":null,"abstract":"This article shows methods for the preparation of 8-bromoadenosine which is an important intermediate in the syntheses of analogs of purines nucleosides and nucleotides with a broad spectrum of biological activity. The influence of the pH values of the medium on the yield of 8-bromoadenosine was studied. It was showed that pH 4.3 is optimal for the preparation of 8-bromoadenosine by reaction of adenosine with a solution of bromine in water.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121767044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-115-117
O. A. Sokolovich, N. V. Bogdanova, V. Sagan, K. Y. Bulanova
As a result of studies, information of the influence of cAMP and nelarabine on the processes of fibrillation of insulin molecules is presented. In vitro experiments revealed that cAMP and nelarabine reduces the process of fibrillation.
{"title":"cAMP AND NELARABINE EFFECTS ON THE FIBRIL FORMATION OF THE INSULIN MOLECULE","authors":"O. A. Sokolovich, N. V. Bogdanova, V. Sagan, K. Y. Bulanova","doi":"10.46646/sakh-2021-2-115-117","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-115-117","url":null,"abstract":"As a result of studies, information of the influence of cAMP and nelarabine on the processes of fibrillation of insulin molecules is presented. In vitro experiments revealed that cAMP and nelarabine reduces the process of fibrillation.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116573329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-83-86
I. D. Pashkouskaya, N. Nechipurenko, A. Zajogin, T. Prokopenko
The study of macro-and microelements in the blood and hair was carried out in 91 patients with ischemic stroke and 24 practically healthy persons, the results of which were taken as normal. It was found that in the blood of patients with ischemic stroke, the concentrations of magnesium, iron, copper, lithium, and aluminum are reduced, and a decrease in the levels of calcium, magnesium, iron, copper, and zinc in the hair was revealed. It has been shown that calcium, magnesium, zinc, and iron in hair have high diagnostic sensitivity, specificity, and efficiency (more than 60%) in ischemic stroke and they can be used as additional informative chemical markers of this pathology.
{"title":"CONTENT OF MACRO- AND MICROELEMENTS IN BLOOD AND HAIR WITH DETERMINATION OF THEIR DIAGNOSTIC SIGNIFICANCE IN PATIENTS WITH ISCHEMIC STROKE","authors":"I. D. Pashkouskaya, N. Nechipurenko, A. Zajogin, T. Prokopenko","doi":"10.46646/sakh-2021-2-83-86","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-83-86","url":null,"abstract":"The study of macro-and microelements in the blood and hair was carried out in 91 patients with ischemic stroke and 24 practically healthy persons, the results of which were taken as normal. It was found that in the blood of patients with ischemic stroke, the concentrations of magnesium, iron, copper, lithium, and aluminum are reduced, and a decrease in the levels of calcium, magnesium, iron, copper, and zinc in the hair was revealed. It has been shown that calcium, magnesium, zinc, and iron in hair have high diagnostic sensitivity, specificity, and efficiency (more than 60%) in ischemic stroke and they can be used as additional informative chemical markers of this pathology.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117290781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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