Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-103-107
A. Svirskaya, K. Komissarov, E. Minchenko, N. A. Manaeva, D. Nizheharodava
The redistribution of Y5T-lymphocytes subpopulations in the peripheral blood characterized by a predominance of tissue-resident cells as well as changes in their activation and cytotoxic potential were established in patients with IgA-nephropathy as compared to healthy donors what may be used as potential biomarkers in the early diagnosis of kidney autoimmune pathology.
{"title":"THE COMPOSITION OF y6T-LYMPHOCYTES IN PATIENTS WITH IgA-NEPHROPATHY","authors":"A. Svirskaya, K. Komissarov, E. Minchenko, N. A. Manaeva, D. Nizheharodava","doi":"10.46646/sakh-2021-2-103-107","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-103-107","url":null,"abstract":"The redistribution of Y5T-lymphocytes subpopulations in the peripheral blood characterized by a predominance of tissue-resident cells as well as changes in their activation and cytotoxic potential were established in patients with IgA-nephropathy as compared to healthy donors what may be used as potential biomarkers in the early diagnosis of kidney autoimmune pathology.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128692270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-96-99
A. S. Rodzkin, T. S. Erchinskaya, N. Ikonnikova
The content of the main biochemical components: protein, polysaccharides, lipids, melanin pigments, and phenolic compounds was studied in the fruit bodies of strains of fungi of the genera Ganoderma, Inonotus, Phallus, and Pleurotus. The amount of total and true protein was 14.6-28.0% and 10.9-18.5%, respectively, polysaccharides-10.8-28.4%, lipids-3.1-3.5%, phenolic compounds-580-2200 mg%. Higher protein content was observed in the strains of the fungus P. ostreatus, polysaccharides - in the strains of G. lucidum and Ph. impudicus, phenolic compounds in the strains of the fungus I. obliquus. The largest amount of polysaccharides (22.0-24.0 %) was isolated from the fruit bodies of G. lucidum (reishi). The leader in the content of polysaccharides in the dry biomass of fruit bodies is the fungus Phallus impudicus (common Veselka). The fruit bodies of Chaga I. obliquus (strains KI 5, KI 7) and Veselka Ph. impudicus (strains PI 2, PI 5, and PI 9) contained significant amounts of melanin pigments - 10.3-13.8% and 7.1-7.4%, respectively.
{"title":"BIOCHEMICAL CHARACTERISTICS OF THE COMPONENT COMPOSITION OF FRUIT BODIES OF MEDICINAL BASIDIOMYCETES","authors":"A. S. Rodzkin, T. S. Erchinskaya, N. Ikonnikova","doi":"10.46646/sakh-2021-2-96-99","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-96-99","url":null,"abstract":"The content of the main biochemical components: protein, polysaccharides, lipids, melanin pigments, and phenolic compounds was studied in the fruit bodies of strains of fungi of the genera Ganoderma, Inonotus, Phallus, and Pleurotus. The amount of total and true protein was 14.6-28.0% and 10.9-18.5%, respectively, polysaccharides-10.8-28.4%, lipids-3.1-3.5%, phenolic compounds-580-2200 mg%. Higher protein content was observed in the strains of the fungus P. ostreatus, polysaccharides - in the strains of G. lucidum and Ph. impudicus, phenolic compounds in the strains of the fungus I. obliquus. The largest amount of polysaccharides (22.0-24.0 %) was isolated from the fruit bodies of G. lucidum (reishi). The leader in the content of polysaccharides in the dry biomass of fruit bodies is the fungus Phallus impudicus (common Veselka). The fruit bodies of Chaga I. obliquus (strains KI 5, KI 7) and Veselka Ph. impudicus (strains PI 2, PI 5, and PI 9) contained significant amounts of melanin pigments - 10.3-13.8% and 7.1-7.4%, respectively.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116557143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-408-411
М. А. Ibrakhim, М. M. Ibrakhim
The development of a system for processing and storing data when booking is considered. The necessity of automation of processes, reliable storage of data, saving of human and paper resources is substantiated.
{"title":"DATA PROCESSING AND STORAGE FOR THE BOOKING AUTOMATION SYSTEM","authors":"М. А. Ibrakhim, М. M. Ibrakhim","doi":"10.46646/sakh-2021-2-408-411","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-408-411","url":null,"abstract":"The development of a system for processing and storing data when booking is considered. The necessity of automation of processes, reliable storage of data, saving of human and paper resources is substantiated.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130239885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-184-188
G. Krusir, O. Sagdeeva, A. S. Gnezdovsky, A. Tsykalo
The work is devoted to the study of the solid waste enzymatic destruction process from fruit and vegetable canning enterprises for the introduction of an improved technology for their utilization and the creation of an optimally balanced feed additive. Enzymatic destruction of cellulose in the waste composition by cellulase under the microorganisms influence is the basis of the biotechnological process. The main characteristics of the enzymatic destruction process have been determined and data have been obtained for improving the technology of solid waste utilization from enterprises of the canning industry. Comparative analysis of bioconversion of the waste various types proves that enzymatic destruction by cellulase is effective specifically for the fruit and vegetable pomace in the waste composition, allows you to obtain a valuable feed additive from them and reduce the stress level on the environment.
{"title":"INVESTIGATION OF THE SOLID WASTE ENZYMATIC DEGRADATION OF THE ENTERPRISES OF THE FRUIT AND VEGETABLE CANNING INDUSTRY","authors":"G. Krusir, O. Sagdeeva, A. S. Gnezdovsky, A. Tsykalo","doi":"10.46646/sakh-2021-2-184-188","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-184-188","url":null,"abstract":"The work is devoted to the study of the solid waste enzymatic destruction process from fruit and vegetable canning enterprises for the introduction of an improved technology for their utilization and the creation of an optimally balanced feed additive. Enzymatic destruction of cellulose in the waste composition by cellulase under the microorganisms influence is the basis of the biotechnological process. The main characteristics of the enzymatic destruction process have been determined and data have been obtained for improving the technology of solid waste utilization from enterprises of the canning industry. Comparative analysis of bioconversion of the waste various types proves that enzymatic destruction by cellulase is effective specifically for the fruit and vegetable pomace in the waste composition, allows you to obtain a valuable feed additive from them and reduce the stress level on the environment.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122682899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-111-114
Yu. V. Serdukov, А. Y. Adamovich, V. K. Shadrina, D. Nizheharodava
The morpho-functional characteristics (viability, sterility, immunophenotype, proliferative and differentiation potential, immunosuppressive properties) of multipotent mesenchymal stromal cells obtained from donors of different age groups are presented in this work.
{"title":"THE COMPARISON OF MULTIPOTENT MESENCHYMAL STROMAL CELLS IN DONORS OF DIFFERENT AGE GROUPS","authors":"Yu. V. Serdukov, А. Y. Adamovich, V. K. Shadrina, D. Nizheharodava","doi":"10.46646/sakh-2021-2-111-114","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-111-114","url":null,"abstract":"The morpho-functional characteristics (viability, sterility, immunophenotype, proliferative and differentiation potential, immunosuppressive properties) of multipotent mesenchymal stromal cells obtained from donors of different age groups are presented in this work.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130766659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-27-30
S. Bruyakin, D. Makarevich
The S1 protein of SARS-CoV-2 (hereinafter referred to as the S1 protein) is probably the main factor in the pathogenesis of COVID-19. In our opinion, the elimination or decrease in the concentration of this protein will reduce the inflammatory process and, accordingly, damage to organs and tissues by the activated immune system. An analysis of the complexes of the Angiotensin-converting enzyme 2 (ACE2) and the S1 protein (ACE2-S1) will determine the oligopeptides that are ligands for binding the S1 protein, the timely removal of which from the blood of patients with COVID-19 will prevent the development of severe multi-organ complications. Besides, the immobilized oligopeptide that binds the S1 protein will be able to remove from the body viral particles located in the extracellular space [1].
{"title":"MODELING OF POTENTIAL PROTEIN S1 SARS-COV-2 LIGANDS","authors":"S. Bruyakin, D. Makarevich","doi":"10.46646/sakh-2021-2-27-30","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-27-30","url":null,"abstract":"The S1 protein of SARS-CoV-2 (hereinafter referred to as the S1 protein) is probably the main factor in the pathogenesis of COVID-19. In our opinion, the elimination or decrease in the concentration of this protein will reduce the inflammatory process and, accordingly, damage to organs and tissues by the activated immune system. An analysis of the complexes of the Angiotensin-converting enzyme 2 (ACE2) and the S1 protein (ACE2-S1) will determine the oligopeptides that are ligands for binding the S1 protein, the timely removal of which from the blood of patients with COVID-19 will prevent the development of severe multi-organ complications. Besides, the immobilized oligopeptide that binds the S1 protein will be able to remove from the body viral particles located in the extracellular space [1].","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131128791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-226-230
V. Shimalov
The monitoring results of the helminth fauna of small rodents living on meliorative channel banks in the mixed forests of Western Belarusian Polesie (Brest Polesie) in 2015-2016 are presented. One hundred and seventeen specimens of three rodent species are caught. 72.3 % of red-backed voles and 60.0 % of yellow-necked mice are found infected by helminths. Seventeen helminth species (2 species of trematodes, 7 species of cestodes, 8 species of nematodes) are found. Twelve species of helminths are localized in red-backed voles, and nine species of helminths in yellow-necked mice. The nematode Heligmosomum mixtum Schulz, 1954 dominates in the infestation of red-backed voles, while the cestode Skrjabinotaenia lobata (Baer, 1925) and the nematode Syphacia frederici Roman, 1945 dominates in the infestation of yellow-necked mice. Four species of helminths identified in rodents are of medical and veterinary significance.
{"title":"MONITORING OF HELMINTH FAUNA OF SMALL RODENTS LIVING ON THE BANKS OF MELIORATIVE CHANNELS IN MIXED FOREST OF BELORUSSIAN POLESIE","authors":"V. Shimalov","doi":"10.46646/sakh-2021-2-226-230","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-226-230","url":null,"abstract":"The monitoring results of the helminth fauna of small rodents living on meliorative channel banks in the mixed forests of Western Belarusian Polesie (Brest Polesie) in 2015-2016 are presented. One hundred and seventeen specimens of three rodent species are caught. 72.3 % of red-backed voles and 60.0 % of yellow-necked mice are found infected by helminths. Seventeen helminth species (2 species of trematodes, 7 species of cestodes, 8 species of nematodes) are found. Twelve species of helminths are localized in red-backed voles, and nine species of helminths in yellow-necked mice. The nematode Heligmosomum mixtum Schulz, 1954 dominates in the infestation of red-backed voles, while the cestode Skrjabinotaenia lobata (Baer, 1925) and the nematode Syphacia frederici Roman, 1945 dominates in the infestation of yellow-necked mice. Four species of helminths identified in rodents are of medical and veterinary significance.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126793276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-286-289
M. M. Haqdod, Z. Kobuliev, A. S. Haqdodov
The issue of safe management of uranium production waste is very relevant for Tajikistan, since the storage conditions do not meet modern requirements for radiation safety, and bringing these facilities to a state of safety requires significant financial costs and consolidation of efforts at the international level.
{"title":"INTERNATIONAL EFFORTS TO REHABILITATE URANIUM HERITAGE SITES OF TAJIKISTAN","authors":"M. M. Haqdod, Z. Kobuliev, A. S. Haqdodov","doi":"10.46646/sakh-2021-2-286-289","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-286-289","url":null,"abstract":"The issue of safe management of uranium production waste is very relevant for Tajikistan, since the storage conditions do not meet modern requirements for radiation safety, and bringing these facilities to a state of safety requires significant financial costs and consolidation of efforts at the international level.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115989632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-404-408
V. Zhuravkov, B. Tonkonogov
The article presents conceptual approaches to the creation of an information resource «Online monitoring system for the state of environmental components of Orsha and Orsha district». The work was carried out within the framework of the State Program «Environmental Protection and Sustainable Use of Natural Resources» for 2016 -2020, approved by the resolution of the Council of Ministers of the Republic of Belarus No. 205. of 17.03.2016.
{"title":"DEVELOPMENT OF THE INFORMATION AND ANALYTICAL RESOURCE «ONLINE MONITORING SYSTEM FOR THE STATE OF ENVIRONMENTAL COMPONENTS OF ORSHA AND ORSHA DISTRICT»","authors":"V. Zhuravkov, B. Tonkonogov","doi":"10.46646/sakh-2021-2-404-408","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-404-408","url":null,"abstract":"The article presents conceptual approaches to the creation of an information resource «Online monitoring system for the state of environmental components of Orsha and Orsha district». The work was carried out within the framework of the State Program «Environmental Protection and Sustainable Use of Natural Resources» for 2016 -2020, approved by the resolution of the Council of Ministers of the Republic of Belarus No. 205. of 17.03.2016.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122671998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-41-44
E. S. Deusova, M. Khancheuski, E. Kvasyuk
Nucleoside derivatives with broken sugar moiety like dialdehydes or trioles have unusual structures and are called seco-nucleosides. They have different types of biological activity which till this time have not been studied enough. It is a result of the high reactivity of aldehydes and hydroxyl groups and the unusual structure of compounds. This article presents two approaches for the synthesis of trihydroxy-inosine from inosine. It was shown that the method for oxidation of diol groups of ribonucleosides using the ion exchange resin in IO4-former has preferences to the method which used NaIO4 as a reagent.
{"title":"SYNTHESIS OF TRIHYDROXY-INOSINE","authors":"E. S. Deusova, M. Khancheuski, E. Kvasyuk","doi":"10.46646/sakh-2021-2-41-44","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-41-44","url":null,"abstract":"Nucleoside derivatives with broken sugar moiety like dialdehydes or trioles have unusual structures and are called seco-nucleosides. They have different types of biological activity which till this time have not been studied enough. It is a result of the high reactivity of aldehydes and hydroxyl groups and the unusual structure of compounds. This article presents two approaches for the synthesis of trihydroxy-inosine from inosine. It was shown that the method for oxidation of diol groups of ribonucleosides using the ion exchange resin in IO4-former has preferences to the method which used NaIO4 as a reagent.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129769583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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