Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-10-13
O. S. Aksenenko
A statistical analysis of the incidence of lung cancer in the period from 2013-2019 and the prevention of lung cancer was carried out. The databases of the Minsk City Clinical Oncology Dispensary were studied and analyzed for 2013, 2014, 2015, 2016, 2017, 2018, 2019 years.
{"title":"INCIDENCE AND PREVENTION OF LUNG CANCER IN THE REPUBLIC OF BELARUS","authors":"O. S. Aksenenko","doi":"10.46646/sakh-2021-2-10-13","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-10-13","url":null,"abstract":"A statistical analysis of the incidence of lung cancer in the period from 2013-2019 and the prevention of lung cancer was carried out. The databases of the Minsk City Clinical Oncology Dispensary were studied and analyzed for 2013, 2014, 2015, 2016, 2017, 2018, 2019 years.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"45 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133680911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-293-296
А. А. Butsko, А. А. Kirukhin, V. Pashynski, А. I. Rodzkin
The article presents the results of the development of a stochastic model for simulating time meteorological series (stochastic weather generator). Modeling of artificial meteorological series with a discreteness of one day is performed on the basis of the Monte Carlo method for the following elements: maximum and minimum air temperature, solar radiation, wind speed, relative humidity, amount and intensity of precipitation. When developing the stochastic model, the ground-level network observations of the State Institution «Republican Hydrometeorological Center» for the Minsk OMN (ф = 53.92°, Z = 27.63°) obtained for the period from 2000-2020 were used. The resulting simulated meteorological series are statistically identical to the actual series.
{"title":"STOCHASTIC MODEL FOR SIMULATING TIME SERIES OF METEOROLOGICAL ELEMENTS","authors":"А. А. Butsko, А. А. Kirukhin, V. Pashynski, А. I. Rodzkin","doi":"10.46646/sakh-2021-2-293-296","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-293-296","url":null,"abstract":"The article presents the results of the development of a stochastic model for simulating time meteorological series (stochastic weather generator). Modeling of artificial meteorological series with a discreteness of one day is performed on the basis of the Monte Carlo method for the following elements: maximum and minimum air temperature, solar radiation, wind speed, relative humidity, amount and intensity of precipitation. When developing the stochastic model, the ground-level network observations of the State Institution «Republican Hydrometeorological Center» for the Minsk OMN (ф = 53.92°, Z = 27.63°) obtained for the period from 2000-2020 were used. The resulting simulated meteorological series are statistically identical to the actual series.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132744588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-76-79
A. Morozova, A. Bakunovich
The leading cause of human death throughout the world is atherothrombosis of various localization. The key point in the fight against this pathology is the appointment of antiplatelet agents. These drugs differ from each other in the mechanism of inhibiting platelet activity. Prasugrel, an antagonist of the thienopyridine class, is a potent inhibitor of platelet activation and aggregation mediated by platelet ADP receptors of the P2Y12 class.
{"title":"MOLECULAR MODELING OF THE P2Y12 COMPLEX OF HUMAN RECEPTOR WITH R-138727 MOLECULE","authors":"A. Morozova, A. Bakunovich","doi":"10.46646/sakh-2021-2-76-79","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-76-79","url":null,"abstract":"The leading cause of human death throughout the world is atherothrombosis of various localization. The key point in the fight against this pathology is the appointment of antiplatelet agents. These drugs differ from each other in the mechanism of inhibiting platelet activity. Prasugrel, an antagonist of the thienopyridine class, is a potent inhibitor of platelet activation and aggregation mediated by platelet ADP receptors of the P2Y12 class.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133606965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-45-48
Y. V. Zhyltsova, E. A. Sinevich, N. Smolnik, P. R. Khilimonchyk
The work analyzes the factors influencing the development of excess, deficiency, or imbalance of macro-and microelements in the organism of 7-10-year-old children living in a large industrial city. Based on a questionnaire survey, it was revealed that the development of natural exogenous microelementosis associated with a lack of B, Mo, Zn, Mn, Se in the soil is subject to more than 80 % of respondents, iodine deficiency - 30 %. The risks of acquiring technogenic microelementosis by the population are possible as a result of the increased content of Pb, Cu, Sn, Cr, Co in the soil, Ni, Sn, Zr, Cr, Cu, Co in the production of meadow and agrophytocenoses, Fe and Mn in the water. More than 40 % of children consume tap water without preliminary preparation, 4 % of families periodically use water from wells. The development of natural endogenous microelementosis is possible in 12-58 % cases, iatrogenic microelementosis - in more than 6 % cases.
{"title":"ANALYSIS OF MICROELEMENTOSIS FORMATION FACTORS OF ZHODINO’ PRIMARY SCHOOL AGE CHILDREN","authors":"Y. V. Zhyltsova, E. A. Sinevich, N. Smolnik, P. R. Khilimonchyk","doi":"10.46646/sakh-2021-2-45-48","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-45-48","url":null,"abstract":"The work analyzes the factors influencing the development of excess, deficiency, or imbalance of macro-and microelements in the organism of 7-10-year-old children living in a large industrial city. Based on a questionnaire survey, it was revealed that the development of natural exogenous microelementosis associated with a lack of B, Mo, Zn, Mn, Se in the soil is subject to more than 80 % of respondents, iodine deficiency - 30 %. The risks of acquiring technogenic microelementosis by the population are possible as a result of the increased content of Pb, Cu, Sn, Cr, Co in the soil, Ni, Sn, Zr, Cr, Cu, Co in the production of meadow and agrophytocenoses, Fe and Mn in the water. More than 40 % of children consume tap water without preliminary preparation, 4 % of families periodically use water from wells. The development of natural endogenous microelementosis is possible in 12-58 % cases, iatrogenic microelementosis - in more than 6 % cases.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115008809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-107-110
A. N. Semak, E. Busko, V. Stelmakh
The study of the genesis of domestic animals in zoogeographic, phylogenetic and cytogenetic aspects allowed us to identify patterns of occurrence and development of various diseases and to predict their dynamics in connection with changes in the complex conditions of their habitat. It was found that among the examined group of dogs in 80,3% of cases were benign neoplasms, in 19,7% of cases the possibility of the occurrence and development of malignant neoplasms was diagnosed. Malignant neoplasms of the skin among the examined cats are detected more often and make up 63,0%, benign - 37,0%, respectively.
{"title":"MEDICAL-ECOLOGICAL AND CYTOGENETIC ASSESSMENT OF INDICATORS OF THE SKIN OF DOMESTIC ANIMALS OF THE CANINE FAMILY (CANIDAE) AND FELIDS (FELIDAE) OF CENTRAL BELARUS","authors":"A. N. Semak, E. Busko, V. Stelmakh","doi":"10.46646/sakh-2021-2-107-110","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-107-110","url":null,"abstract":"The study of the genesis of domestic animals in zoogeographic, phylogenetic and cytogenetic aspects allowed us to identify patterns of occurrence and development of various diseases and to predict their dynamics in connection with changes in the complex conditions of their habitat. It was found that among the examined group of dogs in 80,3% of cases were benign neoplasms, in 19,7% of cases the possibility of the occurrence and development of malignant neoplasms was diagnosed. Malignant neoplasms of the skin among the examined cats are detected more often and make up 63,0%, benign - 37,0%, respectively.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121726511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-153-155
B. Adamovich
Trophic status is one of the key characteristics of aquatic ecosystems, which most adequately reflects the level of eutrophication of natural waters. We have shown the possibility of using the Carlson trophic state index (TSI) for assessment of the trophicity of surface waters in Belarus on the example of the lakes of the Naroch region.
{"title":"TROPHIC STATUS AS AN IMPORTANT INDICATOR OF THE ECOLOGICAL STATE OF WATER ECOSYSTEMS","authors":"B. Adamovich","doi":"10.46646/sakh-2021-2-153-155","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-153-155","url":null,"abstract":"Trophic status is one of the key characteristics of aquatic ecosystems, which most adequately reflects the level of eutrophication of natural waters. We have shown the possibility of using the Carlson trophic state index (TSI) for assessment of the trophicity of surface waters in Belarus on the example of the lakes of the Naroch region.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123991542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-327-331
L. Shapovalova, E. Y. Kirshina, V. Nurmatova, S. Mirzalimova
The article presents the results of studies of systems with natural aeration (NAS) used for the treatment of domestic wastewater in the countries of Central Asia, both in cities and in small settlements. NAS of artificial and natural origin, with depths of 2.0-4.0 m were studied. It was shown that in their hydrological characteristics NAS are close to natural reservoirs of the lake-pond complex - eutrophic lakes. It has been established that during the operation bottom sediments accumulate in them, the greatest thickness of which is noted in the initial part of the NAS. The formation of bottom sediments occurs under anaerobic conditions with the active participation of bacterial microflora in the processes of mineralization. In terms of moisture, ash content and organic matter content, NAS bottom sediments are similar to sapropels of eutrophic lakes.
{"title":"COMPARATIVE CHARACTERISTICS OF LAKE SAPROPELS AND BOTTOM SEDIMENTS IN SYSTEMS WITH NATURAL AERATION","authors":"L. Shapovalova, E. Y. Kirshina, V. Nurmatova, S. Mirzalimova","doi":"10.46646/sakh-2021-2-327-331","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-327-331","url":null,"abstract":"The article presents the results of studies of systems with natural aeration (NAS) used for the treatment of domestic wastewater in the countries of Central Asia, both in cities and in small settlements. NAS of artificial and natural origin, with depths of 2.0-4.0 m were studied. It was shown that in their hydrological characteristics NAS are close to natural reservoirs of the lake-pond complex - eutrophic lakes. It has been established that during the operation bottom sediments accumulate in them, the greatest thickness of which is noted in the initial part of the NAS. The formation of bottom sediments occurs under anaerobic conditions with the active participation of bacterial microflora in the processes of mineralization. In terms of moisture, ash content and organic matter content, NAS bottom sediments are similar to sapropels of eutrophic lakes.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122717523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-415-418
I. Lefanova, T. V. Smirnova
Compartmental models are used for mathematical modeling and subsequent computational experiment of the dynamics of the spread of infectious diseases. The initial population is divided into isolated compartments (compartments), individuals move between the compartments in accordance with the specified parameters. These models most often work with systems of ordinary differential equations and are used to predict the spread of infectious diseases, the duration of epidemics, make it possible to estimate various epidemiological parameters, and, by introducing the necessary compartments, make it possible to predict the impact of various kinds of public health measures on the development and outcome of infectious disease epidemics.
{"title":"OVERVIEW OF COMPARTMENT MODELS OF INFECTIOUS DISEASES PREVALENCE DYNAMICS","authors":"I. Lefanova, T. V. Smirnova","doi":"10.46646/sakh-2021-2-415-418","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-415-418","url":null,"abstract":"Compartmental models are used for mathematical modeling and subsequent computational experiment of the dynamics of the spread of infectious diseases. The initial population is divided into isolated compartments (compartments), individuals move between the compartments in accordance with the specified parameters. These models most often work with systems of ordinary differential equations and are used to predict the spread of infectious diseases, the duration of epidemics, make it possible to estimate various epidemiological parameters, and, by introducing the necessary compartments, make it possible to predict the impact of various kinds of public health measures on the development and outcome of infectious disease epidemics.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128875014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-195-198
P. N. Paulenka, E. Melnik, A. Liudchik
A methodology and a computer program have been developed for preliminary analysis and selection of qualitative observational data by the atmospheric air monitoring system in order to form a unified database and further more complex processing. The program converts the data to a single specified format, analyzes the completeness of observation data at individual observation periods and possible errors due to poor-quality measuring equipment, calculates the monthly average values of the measured parameters and their variances.
{"title":"METHOD OF PRELIMINARY QUALITY ANALYSIS AND SELECTION OF MEASUREMENT DATA BY ATMOSPHERIC AIR MONITORING SYSTEM FOR FURTHER TREATMENT","authors":"P. N. Paulenka, E. Melnik, A. Liudchik","doi":"10.46646/sakh-2021-2-195-198","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-195-198","url":null,"abstract":"A methodology and a computer program have been developed for preliminary analysis and selection of qualitative observational data by the atmospheric air monitoring system in order to form a unified database and further more complex processing. The program converts the data to a single specified format, analyzes the completeness of observation data at individual observation periods and possible errors due to poor-quality measuring equipment, calculates the monthly average values of the measured parameters and their variances.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130797520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-73-76
Y. Melnikova, Y. V. Laikov
Conjugates of Pd (II) coproporphyrin I N-hydroxysuccinimide ester with ferritin-specific monoclonal antibodies of the IgG2a subclass were obtained in a one-step conjugation reaction, with antigen-binding activity increased by 3-7 times. The two-phase dependence of the functional activity of the conjugates on the depth of modification indicates the presence of two populations of modified amino groups. Modification of the more accessible ones leads to functional activation of the IgG molecule. Advantages in binding to an antigen of modified monoclonal antibodies HSF 102 compared to native monoclonal antibodies are shown.
通过一步偶联反应获得Pd (II) coproporphyrin I n-羟基琥珀酰亚胺酯与IgG2a亚类铁蛋白特异性单克隆抗体的偶联物，其抗原结合活性提高3-7倍。缀合物的功能活性与修饰深度的两相依赖性表明存在两个修饰的氨基群体。更容易接近的修饰导致IgG分子的功能激活。与天然单克隆抗体相比，与修饰单克隆抗体HSF 102的抗原结合的优势显示。
{"title":"GETTING AND CHARACTERISTICS OF COPROPORPHYRIN CONJUGATES OF MONOCLONAL ANTIBODIES","authors":"Y. Melnikova, Y. V. Laikov","doi":"10.46646/sakh-2021-2-73-76","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-73-76","url":null,"abstract":"Conjugates of Pd (II) coproporphyrin I N-hydroxysuccinimide ester with ferritin-specific monoclonal antibodies of the IgG2a subclass were obtained in a one-step conjugation reaction, with antigen-binding activity increased by 3-7 times. The two-phase dependence of the functional activity of the conjugates on the depth of modification indicates the presence of two populations of modified amino groups. Modification of the more accessible ones leads to functional activation of the IgG molecule. Advantages in binding to an antigen of modified monoclonal antibodies HSF 102 compared to native monoclonal antibodies are shown.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124977337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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