Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-327-331
L. Shapovalova, E. Y. Kirshina, V. Nurmatova, S. Mirzalimova
The article presents the results of studies of systems with natural aeration (NAS) used for the treatment of domestic wastewater in the countries of Central Asia, both in cities and in small settlements. NAS of artificial and natural origin, with depths of 2.0-4.0 m were studied. It was shown that in their hydrological characteristics NAS are close to natural reservoirs of the lake-pond complex - eutrophic lakes. It has been established that during the operation bottom sediments accumulate in them, the greatest thickness of which is noted in the initial part of the NAS. The formation of bottom sediments occurs under anaerobic conditions with the active participation of bacterial microflora in the processes of mineralization. In terms of moisture, ash content and organic matter content, NAS bottom sediments are similar to sapropels of eutrophic lakes.
{"title":"COMPARATIVE CHARACTERISTICS OF LAKE SAPROPELS AND BOTTOM SEDIMENTS IN SYSTEMS WITH NATURAL AERATION","authors":"L. Shapovalova, E. Y. Kirshina, V. Nurmatova, S. Mirzalimova","doi":"10.46646/sakh-2021-2-327-331","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-327-331","url":null,"abstract":"The article presents the results of studies of systems with natural aeration (NAS) used for the treatment of domestic wastewater in the countries of Central Asia, both in cities and in small settlements. NAS of artificial and natural origin, with depths of 2.0-4.0 m were studied. It was shown that in their hydrological characteristics NAS are close to natural reservoirs of the lake-pond complex - eutrophic lakes. It has been established that during the operation bottom sediments accumulate in them, the greatest thickness of which is noted in the initial part of the NAS. The formation of bottom sediments occurs under anaerobic conditions with the active participation of bacterial microflora in the processes of mineralization. In terms of moisture, ash content and organic matter content, NAS bottom sediments are similar to sapropels of eutrophic lakes.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122717523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-346-348
E. Kotlyarova
The problem of negative environmental impacts of various types on the environment of built-up territories from the operation of capital construction and urban facilities is currently especially urgent. To solve this problem, at the first stage of the study, a study was made of existing scientific approaches to assessing the state of the environment and the choice of a scientific basis for subsequent studies. Improving the existing scientific base in order to minimize the shortcomings of the available approaches can reduce the risk for society from the increase in anthropogenic pressure on the environment and bring closer the achievement of the global goal in the field of sustainable development of urban areas.
{"title":"SCIENTIFIC BASIS OF ENSURING ENVIRONMENTAL SAFETY OF URBANIZED TERRITORIES","authors":"E. Kotlyarova","doi":"10.46646/sakh-2021-2-346-348","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-346-348","url":null,"abstract":"The problem of negative environmental impacts of various types on the environment of built-up territories from the operation of capital construction and urban facilities is currently especially urgent. To solve this problem, at the first stage of the study, a study was made of existing scientific approaches to assessing the state of the environment and the choice of a scientific basis for subsequent studies. Improving the existing scientific base in order to minimize the shortcomings of the available approaches can reduce the risk for society from the increase in anthropogenic pressure on the environment and bring closer the achievement of the global goal in the field of sustainable development of urban areas.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130028607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-20-23
L. Birichevskaya, M. Vinter, A. A. Doroshevich, M. Khancheuski, E. Kvasyuk, A. Zinchenko
Modified nucleoside 8-bromoadenosine possessing high reactive capacity may serve as a basic compound for the synthesis of a large number of purine antimetabolites showing potentially therapeutic activities toward several tumor and viral diseases. In this study, 8-bromoadenosine was produced by a simple eco-friendly procedure following the treatment of nucleoside precursor adenosine with aqueous bromine solution. In the course of enzymatic transphosphatidylation reaction, the first synthesis of phospholipid derivative of the above-mentioned nucleoside -5‘-(1,2-dimyristoyl phosphatidyl)-8-bromoadenosine was accomplished. Novel compounds may presumably act as non-toxic progenitors of bioactive antimetabolites to be used in drug formulas.
{"title":"SYNTHESIS OF THE MODIFIED NUCLEOSIDE 8-BROMADENOSINE AND ITS PHOSPHOLIPID DERIVATIVE","authors":"L. Birichevskaya, M. Vinter, A. A. Doroshevich, M. Khancheuski, E. Kvasyuk, A. Zinchenko","doi":"10.46646/sakh-2021-2-20-23","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-20-23","url":null,"abstract":"Modified nucleoside 8-bromoadenosine possessing high reactive capacity may serve as a basic compound for the synthesis of a large number of purine antimetabolites showing potentially therapeutic activities toward several tumor and viral diseases. In this study, 8-bromoadenosine was produced by a simple eco-friendly procedure following the treatment of nucleoside precursor adenosine with aqueous bromine solution. In the course of enzymatic transphosphatidylation reaction, the first synthesis of phospholipid derivative of the above-mentioned nucleoside -5‘-(1,2-dimyristoyl phosphatidyl)-8-bromoadenosine was accomplished. Novel compounds may presumably act as non-toxic progenitors of bioactive antimetabolites to be used in drug formulas.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129502623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-73-76
Y. Melnikova, Y. V. Laikov
Conjugates of Pd (II) coproporphyrin I N-hydroxysuccinimide ester with ferritin-specific monoclonal antibodies of the IgG2a subclass were obtained in a one-step conjugation reaction, with antigen-binding activity increased by 3-7 times. The two-phase dependence of the functional activity of the conjugates on the depth of modification indicates the presence of two populations of modified amino groups. Modification of the more accessible ones leads to functional activation of the IgG molecule. Advantages in binding to an antigen of modified monoclonal antibodies HSF 102 compared to native monoclonal antibodies are shown.
通过一步偶联反应获得Pd (II) coproporphyrin I n-羟基琥珀酰亚胺酯与IgG2a亚类铁蛋白特异性单克隆抗体的偶联物，其抗原结合活性提高3-7倍。缀合物的功能活性与修饰深度的两相依赖性表明存在两个修饰的氨基群体。更容易接近的修饰导致IgG分子的功能激活。与天然单克隆抗体相比，与修饰单克隆抗体HSF 102的抗原结合的优势显示。
{"title":"GETTING AND CHARACTERISTICS OF COPROPORPHYRIN CONJUGATES OF MONOCLONAL ANTIBODIES","authors":"Y. Melnikova, Y. V. Laikov","doi":"10.46646/sakh-2021-2-73-76","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-73-76","url":null,"abstract":"Conjugates of Pd (II) coproporphyrin I N-hydroxysuccinimide ester with ferritin-specific monoclonal antibodies of the IgG2a subclass were obtained in a one-step conjugation reaction, with antigen-binding activity increased by 3-7 times. The two-phase dependence of the functional activity of the conjugates on the depth of modification indicates the presence of two populations of modified amino groups. Modification of the more accessible ones leads to functional activation of the IgG molecule. Advantages in binding to an antigen of modified monoclonal antibodies HSF 102 compared to native monoclonal antibodies are shown.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124977337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-415-418
I. Lefanova, T. V. Smirnova
Compartmental models are used for mathematical modeling and subsequent computational experiment of the dynamics of the spread of infectious diseases. The initial population is divided into isolated compartments (compartments), individuals move between the compartments in accordance with the specified parameters. These models most often work with systems of ordinary differential equations and are used to predict the spread of infectious diseases, the duration of epidemics, make it possible to estimate various epidemiological parameters, and, by introducing the necessary compartments, make it possible to predict the impact of various kinds of public health measures on the development and outcome of infectious disease epidemics.
{"title":"OVERVIEW OF COMPARTMENT MODELS OF INFECTIOUS DISEASES PREVALENCE DYNAMICS","authors":"I. Lefanova, T. V. Smirnova","doi":"10.46646/sakh-2021-2-415-418","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-415-418","url":null,"abstract":"Compartmental models are used for mathematical modeling and subsequent computational experiment of the dynamics of the spread of infectious diseases. The initial population is divided into isolated compartments (compartments), individuals move between the compartments in accordance with the specified parameters. These models most often work with systems of ordinary differential equations and are used to predict the spread of infectious diseases, the duration of epidemics, make it possible to estimate various epidemiological parameters, and, by introducing the necessary compartments, make it possible to predict the impact of various kinds of public health measures on the development and outcome of infectious disease epidemics.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128875014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-153-155
B. Adamovich
Trophic status is one of the key characteristics of aquatic ecosystems, which most adequately reflects the level of eutrophication of natural waters. We have shown the possibility of using the Carlson trophic state index (TSI) for assessment of the trophicity of surface waters in Belarus on the example of the lakes of the Naroch region.
{"title":"TROPHIC STATUS AS AN IMPORTANT INDICATOR OF THE ECOLOGICAL STATE OF WATER ECOSYSTEMS","authors":"B. Adamovich","doi":"10.46646/sakh-2021-2-153-155","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-153-155","url":null,"abstract":"Trophic status is one of the key characteristics of aquatic ecosystems, which most adequately reflects the level of eutrophication of natural waters. We have shown the possibility of using the Carlson trophic state index (TSI) for assessment of the trophicity of surface waters in Belarus on the example of the lakes of the Naroch region.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123991542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-76-79
A. Morozova, A. Bakunovich
The leading cause of human death throughout the world is atherothrombosis of various localization. The key point in the fight against this pathology is the appointment of antiplatelet agents. These drugs differ from each other in the mechanism of inhibiting platelet activity. Prasugrel, an antagonist of the thienopyridine class, is a potent inhibitor of platelet activation and aggregation mediated by platelet ADP receptors of the P2Y12 class.
{"title":"MOLECULAR MODELING OF THE P2Y12 COMPLEX OF HUMAN RECEPTOR WITH R-138727 MOLECULE","authors":"A. Morozova, A. Bakunovich","doi":"10.46646/sakh-2021-2-76-79","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-76-79","url":null,"abstract":"The leading cause of human death throughout the world is atherothrombosis of various localization. The key point in the fight against this pathology is the appointment of antiplatelet agents. These drugs differ from each other in the mechanism of inhibiting platelet activity. Prasugrel, an antagonist of the thienopyridine class, is a potent inhibitor of platelet activation and aggregation mediated by platelet ADP receptors of the P2Y12 class.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133606965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-10-13
O. S. Aksenenko
A statistical analysis of the incidence of lung cancer in the period from 2013-2019 and the prevention of lung cancer was carried out. The databases of the Minsk City Clinical Oncology Dispensary were studied and analyzed for 2013, 2014, 2015, 2016, 2017, 2018, 2019 years.
{"title":"INCIDENCE AND PREVENTION OF LUNG CANCER IN THE REPUBLIC OF BELARUS","authors":"O. S. Aksenenko","doi":"10.46646/sakh-2021-2-10-13","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-10-13","url":null,"abstract":"A statistical analysis of the incidence of lung cancer in the period from 2013-2019 and the prevention of lung cancer was carried out. The databases of the Minsk City Clinical Oncology Dispensary were studied and analyzed for 2013, 2014, 2015, 2016, 2017, 2018, 2019 years.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133680911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-181-184
T. A. Korolko, I. Rovenskaya
This article presents an analysis of the main issues in the field of handling objects of the plant world. The features of the use, accounting, removal of plant objects, as well as the conditions for the implementation of compensation measures, are discussed in detail.
{"title":"THE ANALYSIS OF LEGISLATIVE DOCUMENTS OF THE REPUBLIC OF BELARUS IN THE FIELD OF HANDLING OBJECTS OF THE PLANT WORLD","authors":"T. A. Korolko, I. Rovenskaya","doi":"10.46646/sakh-2021-2-181-184","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-181-184","url":null,"abstract":"This article presents an analysis of the main issues in the field of handling objects of the plant world. The features of the use, accounting, removal of plant objects, as well as the conditions for the implementation of compensation measures, are discussed in detail.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122202285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-20DOI: 10.46646/sakh-2021-2-125-128
E. Tarun, E. A. Staselovich, P. Y. Krasovskaya, T. M. Halavach, R. Romanovich
{"title":"ANTIOXIDANT ACTIVITY OF WHEY AND COLOSTRUM HYDROLYZATES COMPLEXES WITH CYCLODEXTRIN","authors":"E. Tarun, E. A. Staselovich, P. Y. Krasovskaya, T. M. Halavach, R. Romanovich","doi":"10.46646/sakh-2021-2-125-128","DOIUrl":"https://doi.org/10.46646/sakh-2021-2-125-128","url":null,"abstract":"","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122205415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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