首页 > 最新文献

IEEE Reviews in Biomedical Engineering最新文献

英文 中文
Toward Clinical Applications of Intelligent Robotic Ultrasound Systems 智能机器人超声系统的临床应用研究。
IF 12 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-10-02 DOI: 10.1109/RBME.2025.3610605
Taiyu Han;Guochen Ning;Hanying Liang;Zihan Li;Zhongliang Jiang;Fang Chen;Yan Kang;Jianwen Luo;Hongen Liao
The Robotic Ultrasound System (RUSS) has the potential to transform medical imaging by addressing limitations such as operator dependency, diagnostic variability, and reproducibility in traditional ultrasound (US) examination. Despite rapid technological advancements, a substantial gap remains between RUSS research progress and clinical adoption. This review examined the clinical roles and engineering advances of RUSS, identifying key barriers to translation. Clinically, it evaluated the current applications of RUSS in supporting US procedures, while from an engineering standpoint, it summarized recent innovations and remaining technical challenges. This review examined the current state-of-the-art RUSS technologies, categorizing them based on diverse organ-specific applications while also analyzing their core functional capabilities. This review revealed a focus disparity: while abdominal US is the most commonly used in clinical practice, vascular-targeted RUSS dominates current research. It also highlighted a misalignment between research priorities and actual clinical tasks. Current studies predominantly focused on autonomous scanning and imaging, with limited attention to downstream tasks such as disease diagnosis and analysis. Building on these observations, it identified critical challenges and future trends in RUSS development. This work provides a foundation for future research, fostering collaboration between clinicians and engineers to accelerate the translation of next-generation RUSS from bench to bedside.
机器人超声系统(RUSS)通过解决传统超声(US)检查中的操作员依赖性、诊断可变性和可重复性等局限性,有可能改变医学成像。尽管技术进步迅速,但RUSS研究进展与临床应用之间仍存在实质性差距。本文综述了RUSS的临床作用和工程进展,确定了翻译的主要障碍。在临床上,它评估了RUSS在支持美国手术中的当前应用,而从工程的角度来看,它总结了最近的创新和仍然存在的技术挑战。本文综述了目前最先进的RUSS技术,根据不同的器官特异性应用对它们进行了分类,同时分析了它们的核心功能。这篇综述揭示了一种焦点差异:虽然腹部US在临床实践中最常用,但血管靶向RUSS在目前的研究中占主导地位。它还强调了研究重点与实际临床任务之间的不一致。目前的研究主要集中在自主扫描和成像,对下游任务如疾病诊断和分析的关注有限。在这些观察的基础上,它确定了俄罗斯发展中的关键挑战和未来趋势。这项工作为未来的研究奠定了基础,促进了临床医生和工程师之间的合作,以加速下一代RUSS从实验室到床边的转化。
{"title":"Toward Clinical Applications of Intelligent Robotic Ultrasound Systems","authors":"Taiyu Han;Guochen Ning;Hanying Liang;Zihan Li;Zhongliang Jiang;Fang Chen;Yan Kang;Jianwen Luo;Hongen Liao","doi":"10.1109/RBME.2025.3610605","DOIUrl":"10.1109/RBME.2025.3610605","url":null,"abstract":"The Robotic Ultrasound System (RUSS) has the potential to transform medical imaging by addressing limitations such as operator dependency, diagnostic variability, and reproducibility in traditional ultrasound (US) examination. Despite rapid technological advancements, a substantial gap remains between RUSS research progress and clinical adoption. This review examined the clinical roles and engineering advances of RUSS, identifying key barriers to translation. Clinically, it evaluated the current applications of RUSS in supporting US procedures, while from an engineering standpoint, it summarized recent innovations and remaining technical challenges. This review examined the current state-of-the-art RUSS technologies, categorizing them based on diverse organ-specific applications while also analyzing their core functional capabilities. This review revealed a focus disparity: while abdominal US is the most commonly used in clinical practice, vascular-targeted RUSS dominates current research. It also highlighted a misalignment between research priorities and actual clinical tasks. Current studies predominantly focused on autonomous scanning and imaging, with limited attention to downstream tasks such as disease diagnosis and analysis. Building on these observations, it identified critical challenges and future trends in RUSS development. This work provides a foundation for future research, fostering collaboration between clinicians and engineers to accelerate the translation of next-generation RUSS from bench to bedside.","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"19 ","pages":"227-247"},"PeriodicalIF":12.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hill-Type Models of Skeletal Muscle and Neuromuscular Actuators: A Systematic Review 骨骼肌和神经肌肉致动器的hill型模型:系统综述。
IF 12 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-09-12 DOI: 10.1109/RBME.2025.3593185
Arnault H Caillet;Andrew T M Phillips;Christopher Carty;Dario Farina;Luca Modenese
Backed by a century of research and development, Hill-type models of skeletal muscle, often including a muscle-tendon complex and neuromechanical interface, are widely used for countless applications. Lacking recent comprehensive reviews, the field of Hill-type modeling is, however, dense and hard-to-explore, with detrimental consequences on innovation. Here we present the first systematic review of Hill-type muscle modeling. It aims to clarify the literature by detailing its contents and critically discussing the state-of-the-art by identifying the latest advances, current gaps, and potential future directions in Hill-type modeling. For this purpose, fifty-eight criteria-abiding Hill-type models were assessed according to a completeness evaluation, which identified the modelled muscle properties, and a modeling evaluation, which considered the level of validation and reusability of the models, as well as their modeling strategy and calibration. It is concluded that most models (1) do not significantly advance beyond historical foundational standards, (2) neglect the importance of parameter identification, (3) lack robust validation, and (4) are not reusable in other studies. Besides providing a convenient tool supported by extensive supplementary materials for navigating the literature, the results of this review highlight the need for global recommendations in Hill-type modeling to optimize inter-study consistency, knowledge transfer, and model reusability.
经过一个世纪的研究和发展,hill型骨骼肌模型,通常包括肌肉-肌腱复合体和神经力学接口,被广泛用于无数的应用。然而,由于缺乏最近全面的综述,hill型建模领域过于密集,难以探索,不利于创新。在这里,我们提出了希尔型肌肉建模的第一个系统综述。它旨在通过详细介绍其内容来澄清文献,并通过确定hill型建模的最新进展,当前差距和潜在的未来方向来批判性地讨论最先进的技术。为此,对58个符合标准的hill型模型进行了完整性评估,完整性评估确定了模型的肌肉特性,建模评估考虑了模型的有效性和可重用性,以及模型的建模策略和校准。得出的结论是,大多数模型(1)没有明显超越历史基础标准,(2)忽视参数识别的重要性,(3)缺乏鲁棒验证,(4)不能在其他研究中重用。除了提供了一个方便的工具,通过大量的补充材料来导航文献,本综述的结果强调了在hill型建模中需要全局推荐,以优化研究间的一致性、知识转移和模型可重用性。
{"title":"Hill-Type Models of Skeletal Muscle and Neuromuscular Actuators: A Systematic Review","authors":"Arnault H Caillet;Andrew T M Phillips;Christopher Carty;Dario Farina;Luca Modenese","doi":"10.1109/RBME.2025.3593185","DOIUrl":"10.1109/RBME.2025.3593185","url":null,"abstract":"Backed by a century of research and development, Hill-type models of skeletal muscle, often including a muscle-tendon complex and neuromechanical interface, are widely used for countless applications. Lacking recent comprehensive reviews, the field of Hill-type modeling is, however, dense and hard-to-explore, with detrimental consequences on innovation. Here we present the first systematic review of Hill-type muscle modeling. It aims to clarify the literature by detailing its contents and critically discussing the state-of-the-art by identifying the latest advances, current gaps, and potential future directions in Hill-type modeling. For this purpose, fifty-eight criteria-abiding Hill-type models were assessed according to a completeness evaluation, which identified the modelled muscle properties, and a modeling evaluation, which considered the level of validation and reusability of the models, as well as their modeling strategy and calibration. It is concluded that most models (1) do not significantly advance beyond historical foundational standards, (2) neglect the importance of parameter identification, (3) lack robust validation, and (4) are not reusable in other studies. Besides providing a convenient tool supported by extensive supplementary materials for navigating the literature, the results of this review highlight the need for global recommendations in Hill-type modeling to optimize inter-study consistency, knowledge transfer, and model reusability.","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"19 ","pages":"159-181"},"PeriodicalIF":12.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11162721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Precision Oncology Through Modeling of Longitudinal and Multimodal Data 通过纵向和多模态数据建模推进精准肿瘤学。
IF 12 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-07-03 DOI: 10.1109/RBME.2025.3577587
Luoting Zhuang;Stephen H. Park;Steven J. Skates;Ashley E. Prosper;Denise R. Aberle;William Hsu
Cancer evolves continuously over time through a complex interplay of genetic, epigenetic, microenvironmental, and phenotypic changes. This dynamic behavior drives uncontrolled cell growth, metastasis, immune evasion, and therapy resistance, posing challenges for effective monitoring and treatment. However, today’s data-driven research in oncology has primarily focused on cross-sectional analysis using data from a single modality, limiting the ability to fully characterize and interpret the disease’s dynamic heterogeneity. Advances in multiscale data collection and computational methods now enable the discovery of longitudinal multimodal biomarkers for precision oncology. Longitudinal data reveal patterns of disease progression and treatment response that are not evident from single-timepoint data, enabling timely abnormality detection and dynamic treatment adaptation. Multimodal data integration offers complementary information from diverse sources for more precise risk assessment and targeting of cancer therapy. In this review, we survey methods of longitudinal and multimodal modeling, highlighting their synergy in providing multifaceted insights for personalized care tailored to the unique characteristics of a patient’s cancer. We summarize the current challenges and future directions of longitudinal multimodal analysis in advancing precision oncology.
随着时间的推移,癌症通过遗传、表观遗传、微环境和表型变化的复杂相互作用不断演变。这种动态行为驱动不受控制的细胞生长、转移、免疫逃避和治疗抵抗,为有效监测和治疗带来挑战。然而,今天的肿瘤学数据驱动研究主要集中在使用单一模式数据的横断面分析,限制了充分表征和解释疾病动态异质性的能力。多尺度数据收集和计算方法的进步现在使精确肿瘤学的纵向多模态生物标志物的发现成为可能。纵向数据揭示了单时间点数据不明显的疾病进展和治疗反应模式,从而能够及时发现异常并动态适应治疗。多模式数据集成提供了来自不同来源的补充信息,以便更精确地进行风险评估和靶向癌症治疗。在这篇综述中,我们调查了纵向和多模态建模的方法,强调了它们在为针对患者癌症的独特特征量身定制个性化护理提供多方面见解方面的协同作用。我们总结了目前的挑战和未来的方向纵向多模态分析在推进精准肿瘤学。
{"title":"Advancing Precision Oncology Through Modeling of Longitudinal and Multimodal Data","authors":"Luoting Zhuang;Stephen H. Park;Steven J. Skates;Ashley E. Prosper;Denise R. Aberle;William Hsu","doi":"10.1109/RBME.2025.3577587","DOIUrl":"10.1109/RBME.2025.3577587","url":null,"abstract":"Cancer evolves continuously over time through a complex interplay of genetic, epigenetic, microenvironmental, and phenotypic changes. This dynamic behavior drives uncontrolled cell growth, metastasis, immune evasion, and therapy resistance, posing challenges for effective monitoring and treatment. However, today’s data-driven research in oncology has primarily focused on cross-sectional analysis using data from a single modality, limiting the ability to fully characterize and interpret the disease’s dynamic heterogeneity. Advances in multiscale data collection and computational methods now enable the discovery of longitudinal multimodal biomarkers for precision oncology. Longitudinal data reveal patterns of disease progression and treatment response that are not evident from single-timepoint data, enabling timely abnormality detection and dynamic treatment adaptation. Multimodal data integration offers complementary information from diverse sources for more precise risk assessment and targeting of cancer therapy. In this review, we survey methods of longitudinal and multimodal modeling, highlighting their synergy in providing multifaceted insights for personalized care tailored to the unique characteristics of a patient’s cancer. We summarize the current challenges and future directions of longitudinal multimodal analysis in advancing precision oncology.","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"19 ","pages":"182-200"},"PeriodicalIF":12.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles and Operation of Virtual Brain Twins 虚拟脑双胞胎原理与操作。
IF 12 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-04-21 DOI: 10.1109/RBME.2025.3562951
Meysam Hashemi;Damien Depannemaecker;Marisa Saggio;Paul Triebkorn;Giovanni Rabuffo;Jan Fousek;Abolfazl Ziaeemehr;Viktor Sip;Anastasios Athanasiadis;Martin Breyton;Marmaduke Woodman;Huifang Wang;Spase Petkoski;Pierpaolo Sorrentino;Viktor Jirsa
Current clinical methods often overlook individual variability by relying on population-wide trials, while mechanism-based trials remain underutilized in neuroscience due to the brain’s complexity. This situation may change through the use of a Virtual Brain Twin (VBT), which is a personalized digital replica of an individual’s brain, integrating structural and functional brain data into advanced computational models and inference algorithms. By bridging the gap between molecular mechanisms, whole-brain dynamics, and imaging data, VBTs enhance the understanding of (patho)physiological mechanisms, advancing insights into both healthy and disordered brain function. Central to VBT is the network modeling that couples mesoscopic representation of neuronal activity through white matter connectivity, enabling the simulation of brain dynamics at a network level. This transformative approach provides interpretable predictive capabilities, supporting clinicians in personalizing treatments and optimizing interventions. This Review outlines the key components of VBT development, covering the conceptual, mathematical, technical, and clinical aspects. We describe the stages of VBT construction–from anatomical coupling and modeling to simulation and Bayesian inference–and demonstrate their applications in resting-state, healthy aging, multiple sclerosis, and epilepsy. Finally, we discuss potential extensions to other neurological disorders, such as Parkinson’s disease, and explore future applications in consciousness research and brain-computer interfaces, paving the way for advancements in personalized medicine and brain-machine integration.
目前的临床方法往往依赖于人群范围的试验而忽略了个体的可变性,而由于大脑的复杂性,基于机制的试验在神经科学中仍未得到充分利用。这种情况可以通过使用虚拟大脑双胞胎(VBT)来改变,这是一种个性化的个人大脑数字复制品,将大脑的结构和功能数据集成到先进的计算模型和推理算法中。通过弥合分子机制、全脑动力学和成像数据之间的差距,vvb增强了对(病理)生理机制的理解,推进了对健康和紊乱大脑功能的认识。VBT的核心是网络建模,通过白质连接耦合神经元活动的介观表征,从而在网络水平上模拟大脑动力学。这种变革性方法提供了可解释的预测能力,支持临床医生个性化治疗和优化干预措施。本综述概述了VBT发展的关键组成部分,包括概念、数学、技术和临床方面。我们描述了VBT构建的各个阶段——从解剖耦合和建模到仿真和贝叶斯推理——并展示了它们在静息状态、健康衰老、多发性硬化症和癫痫中的应用。最后,我们讨论了其他神经系统疾病的潜在扩展,如帕金森病,并探索了未来在意识研究和脑机接口方面的应用,为个性化医疗和脑机集成的进步铺平了道路。
{"title":"Principles and Operation of Virtual Brain Twins","authors":"Meysam Hashemi;Damien Depannemaecker;Marisa Saggio;Paul Triebkorn;Giovanni Rabuffo;Jan Fousek;Abolfazl Ziaeemehr;Viktor Sip;Anastasios Athanasiadis;Martin Breyton;Marmaduke Woodman;Huifang Wang;Spase Petkoski;Pierpaolo Sorrentino;Viktor Jirsa","doi":"10.1109/RBME.2025.3562951","DOIUrl":"10.1109/RBME.2025.3562951","url":null,"abstract":"Current clinical methods often overlook individual variability by relying on population-wide trials, while mechanism-based trials remain underutilized in neuroscience due to the brain’s complexity. This situation may change through the use of a Virtual Brain Twin (VBT), which is a personalized digital replica of an individual’s brain, integrating structural and functional brain data into advanced computational models and inference algorithms. By bridging the gap between molecular mechanisms, whole-brain dynamics, and imaging data, VBTs enhance the understanding of (patho)physiological mechanisms, advancing insights into both healthy and disordered brain function. Central to VBT is the network modeling that couples mesoscopic representation of neuronal activity through white matter connectivity, enabling the simulation of brain dynamics at a network level. This transformative approach provides interpretable predictive capabilities, supporting clinicians in personalizing treatments and optimizing interventions. This Review outlines the key components of VBT development, covering the conceptual, mathematical, technical, and clinical aspects. We describe the stages of VBT construction–from anatomical coupling and modeling to simulation and Bayesian inference–and demonstrate their applications in resting-state, healthy aging, multiple sclerosis, and epilepsy. Finally, we discuss potential extensions to other neurological disorders, such as Parkinson’s disease, and explore future applications in consciousness research and brain-computer interfaces, paving the way for advancements in personalized medicine and brain-machine integration.","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"19 ","pages":"111-139"},"PeriodicalIF":12.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10972118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IEEE Reviews in Biomedical Engineering (R-BME) IEEE生物医学工程评论(R-BME)
IF 17.2 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-28 DOI: 10.1109/RBME.2024.3518719
{"title":"IEEE Reviews in Biomedical Engineering (R-BME)","authors":"","doi":"10.1109/RBME.2024.3518719","DOIUrl":"https://doi.org/10.1109/RBME.2024.3518719","url":null,"abstract":"","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"18 ","pages":"C3-C3"},"PeriodicalIF":17.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10856219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143361452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Harnessing Reviews to Advance Biomedical Engineering's New Horizons 社论:利用评论推进生物医学工程的新视野
IF 17.2 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-28 DOI: 10.1109/RBME.2024.3518852
Bin He
{"title":"Editorial: Harnessing Reviews to Advance Biomedical Engineering's New Horizons","authors":"Bin He","doi":"10.1109/RBME.2024.3518852","DOIUrl":"https://doi.org/10.1109/RBME.2024.3518852","url":null,"abstract":"","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"18 ","pages":"3-4"},"PeriodicalIF":17.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10856220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IEEE Engineering in Medicine and Biology Society 医学与生物工程学会
IF 17.2 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-28 DOI: 10.1109/RBME.2024.3518715
{"title":"IEEE Engineering in Medicine and Biology Society","authors":"","doi":"10.1109/RBME.2024.3518715","DOIUrl":"https://doi.org/10.1109/RBME.2024.3518715","url":null,"abstract":"","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"18 ","pages":"C2-C2"},"PeriodicalIF":17.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10856213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measures and Models of Brain-Heart Interactions 脑-心相互作用的测量和模型。
IF 12 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-23 DOI: 10.1109/RBME.2025.3529363
Diego Candia-Rivera;Luca Faes;Fabrizio de Vico Fallani;Mario Chavez
Exploring brain-heart interactions within various paradigms, including affective computing, human-computer interfaces, and sensorimotor evaluation, has demonstrated enormous potential in biomarker development and neuroscientific research. A range of techniques, from molecular to behavioral approaches, has been proposed to measure these interactions. Different frameworks use signal processing techniques, from estimating brain responses to individual heartbeats to interactions linking the heart to changes in brain organization. This review provides an overview of the most notable signal processing strategies currently used for measuring and modeling brain-heart interactions. It discusses their usability and highlights the main challenges that need to be addressed for future methodological developments. Current methodologies have deepened our understanding of the impact of physiological disruptions on brain-heart interactions, solidifying it as a biomarker. The vast outlook of these methods could provide tools for disease stratification in neurological and psychiatric disorders. As we tackle new methodological challenges, gaining a more profound understanding of how these interactions operate, we anticipate further insights into the role of peripheral neurons and the environmental input from the rest of the body in shaping brain functioning.
在各种范式中探索脑-心相互作用,包括情感计算、人机界面和感觉运动评估,已经在生物标志物开发和神经科学研究中显示出巨大的潜力。一系列的技术,从分子到行为的方法,已经被提出来测量这些相互作用。不同的框架使用信号处理技术,从估计大脑对个体心跳的反应到将心脏与大脑组织变化联系起来的相互作用。本文综述了目前用于测量和模拟脑-心相互作用的最显著的信号处理策略。它讨论了它们的可用性,并强调了未来方法开发需要解决的主要挑战。目前的方法加深了我们对生理中断对脑-心相互作用的影响的理解,巩固了它作为生物标志物的地位。这些方法的广阔前景可以为神经和精神疾病的疾病分层提供工具。随着我们应对新的方法挑战,对这些相互作用的运作方式有了更深刻的理解,我们预计将进一步深入了解外周神经元和来自身体其他部分的环境输入在塑造大脑功能中的作用。
{"title":"Measures and Models of Brain-Heart Interactions","authors":"Diego Candia-Rivera;Luca Faes;Fabrizio de Vico Fallani;Mario Chavez","doi":"10.1109/RBME.2025.3529363","DOIUrl":"10.1109/RBME.2025.3529363","url":null,"abstract":"Exploring brain-heart interactions within various paradigms, including affective computing, human-computer interfaces, and sensorimotor evaluation, has demonstrated enormous potential in biomarker development and neuroscientific research. A range of techniques, from molecular to behavioral approaches, has been proposed to measure these interactions. Different frameworks use signal processing techniques, from estimating brain responses to individual heartbeats to interactions linking the heart to changes in brain organization. This review provides an overview of the most notable signal processing strategies currently used for measuring and modeling brain-heart interactions. It discusses their usability and highlights the main challenges that need to be addressed for future methodological developments. Current methodologies have deepened our understanding of the impact of physiological disruptions on brain-heart interactions, solidifying it as a biomarker. The vast outlook of these methods could provide tools for disease stratification in neurological and psychiatric disorders. As we tackle new methodological challenges, gaining a more profound understanding of how these interactions operate, we anticipate further insights into the role of peripheral neurons and the environmental input from the rest of the body in shaping brain functioning.","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"19 ","pages":"24-40"},"PeriodicalIF":12.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10851428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Survey of Foundation Models in Medicine 医学基础模型综合调查。
IF 12 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-20 DOI: 10.1109/RBME.2025.3531360
Wasif Khan;Seowung Leem;Kyle B. See;Joshua K. Wong;Shaoting Zhang;Ruogu Fang
Foundation models (FMs) are large-scale deep learning models trained on massive datasets, often using self-supervised learning techniques. These models serve as a versatile base for a wide range of downstream tasks, including those in medicine and healthcare. FMs have demonstrated remarkable success across multiple healthcare domains. However, existing surveys in this field do not comprehensively cover all areas where FMs have made significant strides. In this survey, we present a comprehensive review of FMs in medicine, focusing on their evolution, learning strategies, flagship models, applications, and associated challenges. We examine how prominent FMs, such as the BERT and GPT families, are transforming various aspects of healthcare, including clinical large language models, medical image analysis, and omics research. Additionally, we provide a detailed taxonomy of FM-enabled healthcare applications, spanning clinical natural language processing, medical computer vision, graph learning, and other biology- and omics-related tasks. Despite the transformative potential of FMs, they also pose unique challenges. This survey delves into these challenges and highlights open research questions and lessons learned to guide researchers and practitioners. Our goal is to provide valuable insights into the capabilities of FMs in health, facilitating responsible deployment and mitigating associated risks.
基础模型(FMs)是使用大型数据集和自监督学习方法开发的大规模深度学习模型。这些模型可作为不同下游任务(包括医疗保健)的基础。在医疗保健的各个领域采用FMs取得了巨大的成功。现有的基于医疗保健的调查尚未包括所有这些领域。因此,我们对医疗保健中的FMs进行了详细调查。我们专注于FMs的历史、学习策略、旗舰模型、应用和挑战。我们探讨了BERT和GPT家族等FMs如何重塑各种医疗保健领域,包括临床大型语言模型、医学图像分析和组学。此外,我们还提供了由FMs促进的医疗保健应用的详细分类,例如临床NLP、医学计算机视觉、图学习和其他与生物学相关的任务。尽管FMs提供了有希望的机会,但它们也有一些相关的挑战,下面将详细解释。我们还概述了开放的研究问题和潜在的经验教训,以便为研究人员和从业人员提供关于医疗保健中fm功能的见解,以推进其部署并降低相关风险。
{"title":"A Comprehensive Survey of Foundation Models in Medicine","authors":"Wasif Khan;Seowung Leem;Kyle B. See;Joshua K. Wong;Shaoting Zhang;Ruogu Fang","doi":"10.1109/RBME.2025.3531360","DOIUrl":"10.1109/RBME.2025.3531360","url":null,"abstract":"Foundation models (FMs) are large-scale deep learning models trained on massive datasets, often using self-supervised learning techniques. These models serve as a versatile base for a wide range of downstream tasks, including those in medicine and healthcare. FMs have demonstrated remarkable success across multiple healthcare domains. However, existing surveys in this field do not comprehensively cover all areas where FMs have made significant strides. In this survey, we present a comprehensive review of FMs in medicine, focusing on their evolution, learning strategies, flagship models, applications, and associated challenges. We examine how prominent FMs, such as the BERT and GPT families, are transforming various aspects of healthcare, including clinical large language models, medical image analysis, and omics research. Additionally, we provide a detailed taxonomy of FM-enabled healthcare applications, spanning clinical natural language processing, medical computer vision, graph learning, and other biology- and omics-related tasks. Despite the transformative potential of FMs, they also pose unique challenges. This survey delves into these challenges and highlights open research questions and lessons learned to guide researchers and practitioners. Our goal is to provide valuable insights into the capabilities of FMs in health, facilitating responsible deployment and mitigating associated risks.","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"19 ","pages":"283-304"},"PeriodicalIF":12.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational Analysis of Intravascular OCT Images for Future Clinical Support: A Comprehensive Review 血管内 OCT 图像的计算分析为未来临床提供支持:全面回顾
IF 12 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-16 DOI: 10.1109/RBME.2025.3530244
Juhwan Lee;Yazan Gharaibeh;Pengfei Dong;Luis A. P. Dallan;Gabriel T. R. Pereira;Justin N. Kim;Ammar Hoori;Linxia Gu;Hiram G. Bezerra;Bernardo Cortese;David L. Wilson
Over the past two decades, intravascular optical coherence tomography (IVOCT) has emerged as a promising tool for planning percutaneous coronary interventions (PCI), studying coronary artery disease, and assessing treatments. With its near-histological resolution and optical contrast, IVOCT uniquely evaluates coronary plaque characteristics, enhancing the guidance of interventional procedures. Artificial intelligence (AI) techniques have been widely applied to IVOCT imaging, providing fast and accurate automated interpretation. These techniques hold significant potential for both clinical and research purposes. Clinically, automated analysis offers comprehensive assessments of coronary plaques, leading to better treatment decisions during PCI. For research, automated interpretation of IVOCT opens new avenues to understand the pathophysiology of coronary atherosclerosis. However, these techniques face several limitations, including issues related to spatial resolution, challenges in manual assessments, and the additional time required for these analyses. This review covers recent advancements and applications of AI techniques and computational simulation methods in IVOCT image analysis, including vessel wall segmentation, plaque characterization, stent analysis, and their clinical applications. Furthermore, we discuss the potential of AI-enhanced IVOCT analysis to facilitate personalized decision-making, potentially improving short- and long-term patient outcomes.
在过去的二十年里,血管内光学相干断层扫描(IVOCT)已经成为一种有前途的工具,用于计划经皮冠状动脉介入治疗(PCI),研究冠状动脉疾病和评估治疗。凭借其近组织学分辨率和光学对比度,IVOCT独特地评估冠状动脉斑块特征,增强介入手术的指导。人工智能(AI)技术已广泛应用于IVOCT成像,提供快速、准确的自动解释。这些技术在临床和研究方面都具有巨大的潜力。在临床上,自动分析提供了对冠状动脉斑块的全面评估,从而在PCI期间做出更好的治疗决策。在研究方面,IVOCT的自动解释为了解冠状动脉粥样硬化的病理生理学开辟了新的途径。然而,这些技术面临着一些限制,包括与空间分辨率相关的问题,人工评估的挑战,以及这些分析所需的额外时间。本文综述了人工智能技术和计算模拟方法在IVOCT图像分析中的最新进展和应用,包括血管壁分割、斑块表征、支架分析及其临床应用。此外,我们讨论了人工智能增强的IVOCT分析的潜力,以促进个性化决策,潜在地改善患者的短期和长期结果。
{"title":"Computational Analysis of Intravascular OCT Images for Future Clinical Support: A Comprehensive Review","authors":"Juhwan Lee;Yazan Gharaibeh;Pengfei Dong;Luis A. P. Dallan;Gabriel T. R. Pereira;Justin N. Kim;Ammar Hoori;Linxia Gu;Hiram G. Bezerra;Bernardo Cortese;David L. Wilson","doi":"10.1109/RBME.2025.3530244","DOIUrl":"10.1109/RBME.2025.3530244","url":null,"abstract":"Over the past two decades, intravascular optical coherence tomography (IVOCT) has emerged as a promising tool for planning percutaneous coronary interventions (PCI), studying coronary artery disease, and assessing treatments. With its near-histological resolution and optical contrast, IVOCT uniquely evaluates coronary plaque characteristics, enhancing the guidance of interventional procedures. Artificial intelligence (AI) techniques have been widely applied to IVOCT imaging, providing fast and accurate automated interpretation. These techniques hold significant potential for both clinical and research purposes. Clinically, automated analysis offers comprehensive assessments of coronary plaques, leading to better treatment decisions during PCI. For research, automated interpretation of IVOCT opens new avenues to understand the pathophysiology of coronary atherosclerosis. However, these techniques face several limitations, including issues related to spatial resolution, challenges in manual assessments, and the additional time required for these analyses. This review covers recent advancements and applications of AI techniques and computational simulation methods in IVOCT image analysis, including vessel wall segmentation, plaque characterization, stent analysis, and their clinical applications. Furthermore, we discuss the potential of AI-enhanced IVOCT analysis to facilitate personalized decision-making, potentially improving short- and long-term patient outcomes.","PeriodicalId":39235,"journal":{"name":"IEEE Reviews in Biomedical Engineering","volume":"19 ","pages":"396-411"},"PeriodicalIF":12.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
IEEE Reviews in Biomedical Engineering
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1