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Digital Health and Machine Learning Technologies for Blood Glucose Monitoring and Management of Gestational Diabetes 用于血糖监测和妊娠糖尿病管理的数字健康和机器学习技术。
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2023-02-07 DOI: 10.1109/RBME.2023.3242261
Huiqi Y. Lu;Xiaorong Ding;Jane E. Hirst;Yang Yang;Jenny Yang;Lucy Mackillop;David A. Clifton
Innovations in digital health and machine learning are changing the path of clinical health and care. People from different geographical locations and cultural backgrounds can benefit from the mobility of wearable devices and smartphones to monitor their health ubiquitously. This paper focuses on reviewing the digital health and machine learning technologies used in gestational diabetes – a subtype of diabetes that occurs during pregnancy. This paper reviews sensor technologies used in blood glucose monitoring devices, digital health innovations and machine learning models for gestational diabetes monitoring and management, in clinical and commercial settings, and discusses future directions. Despite one in six mothers having gestational diabetes, digital health applications were underdeveloped, especially the techniques that can be deployed in clinical practice. There is an urgent need to (1) develop clinically interpretable machine learning methods for patients with gestational diabetes, assisting health professionals with treatment, monitoring, and risk stratification before, during and after their pregnancies; (2) adapt and develop clinically-proven devices for patient self-management of health and well-being at home settings (“virtual ward” and virtual consultation), thereby improving clinical outcomes by facilitating timely intervention; and (3) ensure innovations are affordable and sustainable for all women with different socioeconomic backgrounds and clinical resources.
数字健康和机器学习领域的创新正在改变临床健康和护理的路径。来自不同地理位置和文化背景的人们可以从可穿戴设备和智能手机的移动性中受益,随时随地监测自己的健康状况。本文重点回顾了用于妊娠糖尿病(一种发生在孕期的糖尿病亚型)的数字健康和机器学习技术。本文回顾了临床和商业环境中用于血糖监测设备的传感器技术、数字健康创新技术以及用于妊娠糖尿病监测和管理的机器学习模型,并讨论了未来的发展方向。尽管每六位母亲中就有一位患有妊娠糖尿病,但数字健康应用,尤其是可在临床实践中应用的技术,却发展不足。目前迫切需要:(1)为妊娠糖尿病患者开发临床可解释的机器学习方法,协助医护人员在妊娠前、妊娠中和妊娠后进行治疗、监测和风险分层;(2)改造和开发经临床验证的设备,用于患者在家庭环境中自我管理健康和福祉("虚拟病房 "和虚拟咨询),从而通过促进及时干预改善临床结果;以及(3)确保创新对不同社会经济背景和临床资源的所有妇女来说都是可负担和可持续的。
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引用次数: 2
IEEE Engineering in Medicine and Biology Society Information IEEE医学与生物工程学会信息
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2023-01-05 DOI: 10.1109/RBME.2022.3228083
Presents a listing of the editorial board, board of governors, current staff, committee members, and/or society editors for this issue of the publication.
列出本期出版物的编辑委员会、董事会、现任工作人员、委员会成员和/或协会编辑。
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引用次数: 0
IEEE Reviews in Biomedical Engineering (R-BME) Information IEEE生物医学工程(R-BME)信息综述
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2023-01-05 DOI: 10.1109/RBME.2022.3228079
These instructions give guidelines for preparing papers for this publication. Presents information for authors publishing in this journal.
这些说明为编写本出版物的论文提供了指导。为在本期刊上发表文章的作者提供信息。
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引用次数: 0
MRI Coil Development Strategies for Hybrid MR-PET Systems: A Review 混合 MR-PET 系统的 MRI 线圈开发策略:综述。
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-12-07 DOI: 10.1109/RBME.2022.3227337
Chang-Hoon Choi;Jörg Felder;Christoph Lerche;N. Jon Shah
Simultaneously operating MR-PET systems have the potential to provide synergetic multi-parametric information, and, as such, interest surrounding their use and development is increasing. However, despite the potential advantages offered by fully combined MR-PET systems, implementing this hybrid integration is technically laborious, and any factors degrading the quality of either modality must be circumvented to ensure optimal performance. In order to attain the best possible quality from both systems, most full MR-PET integrations tend to place the shielded PET system inside the MRI system, close to the target volume of the subject. The radiofrequency (RF) coil used in MRI systems is a key factor in determining the quality of the MR images, and, in simultaneous acquisition, it is generally positioned inside the PET system and PET imaging region, potentially resulting in attenuation and artefacts in the PET images. Therefore, when designing hybrid MR-PET systems, it is imperative that consideration be given to the RF coils inside the PET system. In this review, we present current state-of-the-art RF coil designs used for hybrid MR-PET experiments and discuss various design strategies for constructing PET transparent RF coils.
同时运行的 MR-PET 系统具有提供多参数协同信息的潜力,因此,人们对其使用和开发的兴趣与日俱增。然而,尽管完全联合的 MR-PET 系统具有潜在的优势,但实施这种混合集成在技术上非常费力,而且必须避免任何降低两种模式质量的因素,以确保最佳性能。为了使两种系统都能达到最佳质量,大多数全面的 MR-PET 集成系统都倾向于将屏蔽 PET 系统置于 MRI 系统内部,靠近受检者的目标容积。MRI 系统中使用的射频(RF)线圈是决定 MR 图像质量的关键因素,而在同步采集中,它通常位于 PET 系统和 PET 成像区域内,可能会导致 PET 图像的衰减和伪影。因此,在设计 MR-PET 混合系统时,必须考虑 PET 系统内的射频线圈。在本综述中,我们将介绍目前用于混合 MR-PET 实验的最先进的射频线圈设计,并讨论构建 PET 透明射频线圈的各种设计策略。
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引用次数: 1
Editorial A Message From the New Editor-in-Chief 社论新任总编辑寄语
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-11-10 DOI: 10.1109/RBME.2022.3221366
Bin He
Presents the introductory editorial for this issue of the publication.
介绍本期出版物的介绍性社论。
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引用次数: 0
Spectral Analysis of Heart Rate Variability in Time-Varying Conditions and in the Presence of Confounding Factors 时变条件下和存在干扰因素时的心率变异性频谱分析
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-11-08 DOI: 10.1109/RBME.2022.3220636
Leif Sörnmo;Raquel Bailón;Pablo Laguna
The tools for spectrally analyzing heart rate variability (HRV) has in recent years grown considerably, with emphasis on the handling of time-varying conditions and confounding factors. Time–frequency analysis holds since long an important position in HRV analysis, however, this technique cannot alone handle a mean heart rate or a respiratory frequency which vary over time. Overlapping frequency bands represents another critical condition which needs to be dealt with to produce accurate spectral measurements. The present survey offers a comprehensive account of techniques designed to handle such conditions and factors by providing a brief description of the main principles of the different methods. Several methods derive from a mathematical/statistical model, suggesting that the model can be used to simulate data used for performance evaluation. The inclusion of a respiratory signal, whether measured or derived, is another feature of many recent methods, e.g., used to guide the decomposition of the HRV signal so that signals related as well as unrelated to respiration can be analyzed. It is concluded that the development of new approaches to handling time-varying scenarios are warranted, as is benchmarking of performance evaluated in technical as well as in physiological/clinical terms.
近年来,对心率变异性(HRV)进行频谱分析的工具有了很大发展,重点是处理时变条件和混杂因素。长期以来,时频分析在心率变异分析中占据重要地位,但这种技术无法单独处理随时间变化的平均心率或呼吸频率。频带重叠是产生精确频谱测量的另一个关键条件,需要加以解决。本调查通过简述不同方法的主要原理,全面介绍了旨在处理这些条件和因素的技术。有几种方法源自数学/统计模型,表明该模型可用于模拟用于性能评估的数据。许多最新方法的另一个特点是加入了呼吸信号,无论是测量的还是推导的,例如,用于指导心率变异信号的分解,以便分析与呼吸有关或无关的信号。结论是,有必要开发新的方法来处理时变情况,并对技术和生理/临床方面的性能进行基准评估。
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引用次数: 0
A Review in On-Body Compression Using Soft Actuators and Sensors: Applications, Mechanisms, and Challenges 使用软致动器和传感器进行人体压缩的综述:应用、机制和挑战》一书中的一篇评论。
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-11-08 DOI: 10.1109/RBME.2022.3220505
Alireza Golgouneh;Lucy E. Dunne
Body compression through a garment or inflatable pneumatic mechanism has various applications in aesthetic, athletic, robotics, haptics, astronautics, and especially medical fields for treatment of various disorders such as varicose veins, lymphedema, deep vein thrombosis, and orthostatic intolerance. Traditionally, compression has been done through under-sized (e.g. elastic) or size-adjustable (e.g. inflatable) compression garments. Such systems are designed to apply substantially uniform pressure on the body. However, due to reasons such as anatomical variations and body posture change, different levels of compression may be applied to the body. Further, a high level of discomfort and non-compliance is reported among patients due to donning difficulties. Therefore, there have been some efforts to make compression garments smart by employing advanced functional soft materials and actuators (such as Shape Memory Alloy (SMA), Shape Memory Polymer (SMP), Electroactive polymer (EAP), etc.) as well as soft force-pressure sensors so that the compression level could be controlled and regulated for each person or specific tasks. However, despite these advances, there are still challenges to accurately controlling the on-body compression level that are mainly due to the inherent characteristics of the soft actuators or sensors and the sophisticated human body conditions. In this paper, we will first investigate the soft actuators and sensors that have the potential to be used for on-body compression applications. Then, integrated soft sensing-actuation systems for interfacial compression purposes are studied. Finally, the challenges that might be associated with this work are introduced.
通过服装或充气气动装置对人体进行压缩,在美学、运动、机器人、触觉、宇航,特别是医疗领域有多种应用,用于治疗各种疾病,如静脉曲张、淋巴水肿、深静脉血栓和正压性不耐受。传统上,压力治疗是通过尺寸不足(如弹性)或尺寸可调(如充气)的压力衣来实现的。这些系统的设计目的是对身体施加基本均匀的压力。然而,由于解剖结构的变化和身体姿势的改变等原因,可能会对身体施加不同程度的压力。此外,据报道,由于穿戴困难,患者会感到高度不适,并且不服从治疗。因此,人们一直在努力通过采用先进的功能性软材料和致动器(如形状记忆合金(SMA)、形状记忆聚合物(SMP)、电活性聚合物(EAP)等)以及软力-压力传感器来实现压力衣的智能化,从而可以根据每个人或特定任务来控制和调节压力水平。然而,尽管取得了这些进步,但要精确控制人体压缩水平仍面临挑战,这主要是由于软致动器或传感器的固有特性以及复杂的人体条件造成的。在本文中,我们将首先研究有可能用于人体压缩应用的软致动器和传感器。然后,研究用于界面压缩的集成软传感-执行系统。最后,我们将介绍这项工作可能面临的挑战。
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引用次数: 5
Emerging Technologies Used in Health Management and Efficiency Improvement During Different Contact Tracing Phases Against COVID-19 Pandemic 在新冠肺炎大流行的不同接触者追踪阶段用于健康管理和提高效率的新兴技术
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-11-04 DOI: 10.1109/RBME.2022.3219433
Maggie Ezzat Gaber Gendy;Mehmet Rasit Yuce
Confronted with the COVID-19 health crisis, the year 2020 represented a turning point for the entire world. It paved the way for health-care systems to reaffirm their foundations by using different technologies such as sensors, wearables, mobile applications, drones, robots, Artificial Intelligence (AI), Machine Learning (ML) and the Internet of Things (IoT). A lot of domains have been renovated such as diagnosis, treatment, and monitoring, as well as previously unprecedented domains such as contact tracing. Contact tracing, in conjunction with the emergence, spread, and public compliance for vaccines, was a critical step for controlling and limiting the spread of the pandemic. Traditional contact tracing is usually dependent on individuals ability to recall their interactions, which is challenging and yet not effective. Consequently, further development and usage of automated, privacy-preserving, digital contact-tracing was required. As the pandemic is coming to an end, it is vital to collect and learn the effective used technologies that aided in fighting the virus in order to be prepared for any future pandemics and to be aware of any literature gaps that must be filled. This paper surveys state-of-the-art architectures, platforms, and applications combating COVID-19 at each phase of the five basic contact tracing phases, including case identification, contacts identification and rapid exposure notification, surveillance, regular follow up and prevention. In addition, there is a phase of preparation and post-pandemic services for current and needed future technology that will aid in the fight against any incoming infectious diseases.
面对新冠肺炎健康危机,2020年是整个世界的转折点。它通过使用传感器、可穿戴设备、移动应用程序、无人机、机器人、人工智能(AI)、机器学习(ML)和物联网(IoT)等不同技术,为医疗保健系统重申其基础铺平了道路。许多领域都进行了翻新,如诊断、治疗和监测,以及以前前所未有的领域,如接触者追踪。接触者追踪,再加上疫苗的出现、传播和公众对疫苗的遵守,是控制和限制疫情传播的关键一步。传统的接触者追踪通常取决于个人回忆互动的能力,这很有挑战性,但并不有效。因此,需要进一步开发和使用自动化、保护隐私的数字联系人追踪。随着大流行即将结束,收集和学习有助于抗击病毒的有效使用技术至关重要,以便为未来的任何大流行做好准备,并意识到必须填补的任何文献空白。本文调查了在五个基本接触者追踪阶段的每个阶段抗击新冠肺炎的最先进架构、平台和应用程序,包括病例识别、接触者识别和快速接触通知、监测、定期随访和预防。此外,目前和未来所需的技术还有一个准备阶段和疫情后服务阶段,这将有助于对抗任何传入的传染病。
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引用次数: 5
Neuron(s)-on-a-Chip: A Review of the Design and Use of Microfluidic Systems for Neural Tissue Culture 神经元芯片:神经组织培养微流体系统的设计与使用综述》。
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-10-27 DOI: 10.1109/RBME.2022.3217486
David Choy Buentello;Mariana García-Corral;Grissel Trujillo-de Santiago;Mario Moisés Alvarez
Neuron-on-chip (NoC) systems—microfluidic devices in which neurons are cultured—have become a promising alternative to replace or minimize the use of animal models and have greatly facilitated in vitro research. Here, we review and discuss current developments in neuron-on-chip platforms, with a particular emphasis on existing biological models, culturing techniques, biomaterials, and topologies. We also discuss how the architecture, flow, and gradients affect neuronal growth, differentiation, and development. Finally, we discuss some of the most recent applications of NoCs in fundamental research (i.e., studies on the effects of electrical, mechanical/topological, or chemical stimuli) and in disease modeling.
神经元芯片(NoC)系统--培养神经元的微流控设备--已成为替代动物模型或最大限度减少动物模型使用的一种有前途的替代方法,并极大地促进了体外研究。在此,我们回顾并讨论了神经元芯片平台的当前发展,特别强调了现有的生物模型、培养技术、生物材料和拓扑结构。我们还讨论了结构、流动和梯度如何影响神经元的生长、分化和发育。最后,我们还讨论了 NoCs 在基础研究(即电、机械/拓扑或化学刺激效应研究)和疾病建模中的一些最新应用。
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引用次数: 2
Systematic Review of Advanced AI Methods for Improving Healthcare Data Quality in Post COVID-19 Era 后新冠肺炎时代提高医疗保健数据质量的先进人工智能方法的系统回顾
IF 17.6 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2022-10-21 DOI: 10.1109/RBME.2022.3216531
Monica Isgut;Logan Gloster;Katherine Choi;Janani Venugopalan;May D. Wang
At the beginning of the COVID-19 pandemic, there was significant hype about the potential impact of artificial intelligence (AI) tools in combatting COVID-19 on diagnosis, prognosis, or surveillance. However, AI tools have not yet been widely successful. One of the key reason is the COVID-19 pandemic has demanded faster real-time development of AI-driven clinical and health support tools, including rapid data collection, algorithm development, validation, and deployment. However, there was not enough time for proper data quality control. Learning from the hard lessons in COVID-19, we summarize the important health data quality challenges during COVID-19 pandemic such as lack of data standardization, missing data, tabulation errors, and noise and artifact. Then we conduct a systematic investigation of computational methods that address these issues, including emerging novel advanced AI data quality control methods that achieve better data quality outcomes and, in some cases, simplify or automate the data cleaning process. We hope this article can assist healthcare community to improve health data quality going forward with novel AI development.
在新冠肺炎大流行开始时,有人大肆炒作人工智能(AI)工具在抗击新冠肺炎方面对诊断、预后或监测的潜在影响。然而,人工智能工具尚未取得广泛成功。其中一个关键原因是新冠肺炎大流行要求更快地实时开发人工智能驱动的临床和健康支持工具,包括快速数据收集、算法开发、验证和部署。然而,没有足够的时间进行适当的数据质量控制。从新冠肺炎的惨痛教训中,我们总结了新冠肺炎大流行期间重要的健康数据质量挑战,如数据标准化不足、数据缺失、制表错误以及噪音和人为因素。然后,我们对解决这些问题的计算方法进行了系统的研究,包括新兴的先进人工智能数据质量控制方法,这些方法可以实现更好的数据质量结果,在某些情况下,还可以简化或自动化数据清理过程。我们希望这篇文章能够帮助医疗保健界在新的人工智能开发中提高健康数据质量。
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引用次数: 7
期刊
IEEE Reviews in Biomedical Engineering
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