M. Politi, Nahuel Simonet, Eric Kube, Tereza Rumlerová, Edilberto Chuquilín Bustamante, Gary Saucedo Rojas, Fabio Friso, G. Zengin, L. Menghini, C. Ferrante
Aristolochia didyma (Yawar Panga) and other Aristolochia species are used as traditional herbal remedies with potent emetic properties. Scientific data for such Yawar Panga species, however, are scarce in the literature. The aim of this study was to describe the use of Yawar Panga within the context of the therapeutic community Takiwasi, in which the plant is used as part of the protocol for the rehabilitation of individuals with drug addiction. Fieldwork with experts in the administration of Yawar Panga at Takiwasi Center, as well as a retrospective qualitative analysis of experiences with this plant remedy in a residential inpatient population were performed. In-silico analysis of the main constituents of A. didyma as represented in the literature was completed in order to identify its putative pharmacological targets. The therapists interviewed consider Yawar Panga to be the most potent purga at Takiwasi and consider it especially useful in attenuating addiction withdrawal syndrome. From the patient’s perspective, this plant induces strong physical effects, and commonly precipitates effects in the oneiric and emotional dimensions. GABA B seems to be the receptor involved in the emesis induced by the phytochemicals contained in this plant species. Despite some relevant concerns related to the safety of the genus Aristolochia in modern western pharmacopoeias, some species, including A. didyma, are routinely used in the context of traditional herbal medicine in the Peruvian Amazon. Further phyto-pharmacological investigations would be helpful to elaborate this species’ medical utility, especially within the context of addiction treatment.
{"title":"Ethnomedical uses of Yawar Panga (Aristolochia didyma) in a therapeutic community dedicated to the treatment of drug addiction in the Peruvian Amazon","authors":"M. Politi, Nahuel Simonet, Eric Kube, Tereza Rumlerová, Edilberto Chuquilín Bustamante, Gary Saucedo Rojas, Fabio Friso, G. Zengin, L. Menghini, C. Ferrante","doi":"10.53365/nrfhh/159613","DOIUrl":"https://doi.org/10.53365/nrfhh/159613","url":null,"abstract":"Aristolochia didyma (Yawar Panga) and other Aristolochia species are used as traditional herbal remedies with potent emetic properties. Scientific data for such Yawar Panga species, however, are scarce in the literature. The aim of this study was to describe the use of Yawar Panga within the context of the therapeutic community Takiwasi, in which the plant is used as part of the protocol for the rehabilitation of individuals with drug addiction. Fieldwork with experts in the administration of Yawar Panga at Takiwasi Center, as well as a retrospective qualitative analysis of experiences with this plant remedy in a residential inpatient population were performed. In-silico analysis of the main constituents of A. didyma as represented in the literature was completed in order to identify its putative pharmacological targets. The therapists interviewed consider Yawar Panga to be the most potent purga at Takiwasi and consider it especially useful in attenuating addiction withdrawal syndrome. From the patient’s perspective, this plant induces strong physical effects, and commonly precipitates effects in the oneiric and emotional dimensions. GABA B seems to be the receptor involved in the emesis induced by the phytochemicals contained in this plant species. Despite some relevant concerns related to the safety of the genus Aristolochia in modern western pharmacopoeias, some species, including A. didyma, are routinely used in the context of traditional herbal medicine in the Peruvian Amazon. Further phyto-pharmacological investigations would be helpful to elaborate this species’ medical utility, especially within the context of addiction treatment.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124471345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Barros, Leonardo Pereira de Araújo, N. Silveira, B. Santos
It is notorious that since the beginnings of spacetime, the human being lives with microorganisms of countless forms, be it in a positive way as in case of Bacteroidetes present in the intestine’s microbiota or negative way as in case of recent epidemic of Sars-Cov-2. So, the negative impacts caused by microorganisms are objects of study in the whole world, for instance, Candida albicans, which is a fungus that lives in the human body symbiotically and assists in the maintenance of body homeostasis, but the same can present an invasive features that become harmful to the human health, mainly in people who present some kind of immunodeficiency, causing its proliferation to become exacerbated, may cause the death. Said that, the use of drugs to control C. albicans is very important, being the nystatin and fluconazole that are the ones that are currently used. However, the updating of such medicines as time goes by becomes ineffective to some kinds of strains, since the capacity of the fungus in evolution creates resistance to medicines. So, the Discovery of new drugs is necessary and natural products are an excellent research source for the same. Therefore, this study made the methodology in silico of molecular docking to investigate the forms of connection of the natural compounds fukugetin, guttiferone-A, lapachol, mangiferin, plumbagin and 7-epiclusianone in potential molecular targets of fungus Candida albicans.
{"title":"An in silico study involving Mangiferin, 7-Epiclusianone, Fukugetin, Lapachol, Plumbagin and Guttiferone-A against C. albicans proteins","authors":"A. Barros, Leonardo Pereira de Araújo, N. Silveira, B. Santos","doi":"10.53365/nrfhh/158808","DOIUrl":"https://doi.org/10.53365/nrfhh/158808","url":null,"abstract":"It is notorious that since the beginnings of spacetime, the human being lives with microorganisms of countless forms, be it in a positive way as in case of Bacteroidetes present in the intestine’s microbiota or negative way as in case of recent epidemic of Sars-Cov-2. So, the negative impacts caused by microorganisms are objects of study in the whole world, for instance, Candida albicans, which is a fungus that lives in the human body symbiotically and assists in the maintenance of body homeostasis, but the same can present an invasive features that become harmful to the human health, mainly in people who present some kind of immunodeficiency, causing its proliferation to become exacerbated, may cause the death. Said that, the use of drugs to control C. albicans is very important, being the nystatin and fluconazole that are the ones that are currently used. However, the updating of such medicines as time goes by becomes ineffective to some kinds of strains, since the capacity of the fungus in evolution creates resistance to medicines. So, the Discovery of new drugs is necessary and natural products are an excellent research source for the same. Therefore, this study made the methodology in silico of molecular docking to investigate the forms of connection of the natural compounds fukugetin, guttiferone-A, lapachol, mangiferin, plumbagin and 7-epiclusianone in potential molecular targets of fungus Candida albicans.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127622099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Among angiosperms, the Fabaceae (Leguminosae) family is well known for providing traditional or ethnic food and medicine. This family has three subfamilies with approximately 665 genera and 17500 species worldwide, with approximately 1100 species and 100 genera represented in India. Astragalus (>3000 species), Acacia (>1000 species), and Indigofera (>700 species) are the largest genera in this family. Many species in these genera have been identified as producing a variety of phytochemicals, including 3-nitropropanoic acid, a powerful mycotoxin. Almost every tribal community in India is aware of the medicinal uses of leguminous plants. In this regard, India's arid state can be regarded as an extremely rich territory; thus, a review of the scientific literature on their phytochemical characteristics and ethnomedicinal uses is expected to contribute to the further exploration and utilization of members of this large plant family.
{"title":"Ethnomedicinal importance of Fabaceae family (Angiosperms) among the tribes of Rajasthan, India","authors":"R. Shreya, B. Sharma, A. Alam, Supriya Sharma","doi":"10.53365/nrfhh/158809","DOIUrl":"https://doi.org/10.53365/nrfhh/158809","url":null,"abstract":"Among angiosperms, the Fabaceae (Leguminosae) family is well known for providing traditional or ethnic food and medicine. This family has three subfamilies with approximately 665 genera and 17500 species worldwide, with approximately 1100 species and 100 genera represented in India. Astragalus (>3000 species), Acacia (>1000 species), and Indigofera (>700 species) are the largest genera in this family. Many species in these genera have been identified as producing a variety of phytochemicals, including 3-nitropropanoic acid, a powerful mycotoxin. Almost every tribal community in India is aware of the medicinal uses of leguminous plants. In this regard, India's arid state can be regarded as an extremely rich territory; thus, a review of the scientific literature on their phytochemical characteristics and ethnomedicinal uses is expected to contribute to the further exploration and utilization of members of this large plant family.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133662977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Kasali, Muhammad Ali, J. Kadima, J. Tusiimire, M. Lateef, Ruth Omole, Gaétan Tabakam, A. Agaba
Chenopodium ambrosioides is widely used in traditional medicines to manage several health conditions. This study aimed to investigate the chemical composition of the n-hexane fraction and the in vitro antidiabetic and antioxidant properties of C. ambrosioides L. The chemical composition was determined using Gas Chromatography-Flame Ionization Detection and Gas Chromatography-Mass Spectrometry. In vitro evaluations were assessed by evaluating the inhibitory potentials on the activities of α-glucosidase and antioxidants. A total of 58 phytochemicals were identified belonging to 11 classes of substances, of which aliphatic hydrocarbons (38.25%), diterpenes (20.54%), esters (16.33%), triterpenes (11.91%), diverse functional groups (3.74%), aromatic hydrocarbons (2.64%), sesquiterpenes (2.31%), alcohols (1.41%), ketones (0.29%), monoterpenes (0.16%), and fatty acids (0.14%). The major compounds were heptacosane (30.48%) (46), phytol (20.94) (35), and squalene (11.07%) (56). The methanol extract and its fractions showed moderate α-glucosidase activity, but their IC50 values were lower than the positive control 1-deoxynojirimycin. However, the methanol and methanol-water fractions exhibited more scavenging activity on 2,2-diphenyl-1-picrylhydrazyl with IC50 values similar to butylated hydroxyanisole (BHA). The plant is rich in various phytoconstituents, and its α-glucosidase and antioxidant status may justify its use in traditional medicine, especially for preventing complications of diabetes.
{"title":"GC-FID and GC-MS profiling and in vitro antidiabetic and antioxidant activities of Chenopodium ambrosioides L.","authors":"F. Kasali, Muhammad Ali, J. Kadima, J. Tusiimire, M. Lateef, Ruth Omole, Gaétan Tabakam, A. Agaba","doi":"10.53365/nrfhh/156457","DOIUrl":"https://doi.org/10.53365/nrfhh/156457","url":null,"abstract":"Chenopodium ambrosioides is widely used in traditional medicines to manage several health conditions. This study aimed to investigate the chemical composition of the n-hexane fraction and the in vitro antidiabetic and antioxidant properties of C. ambrosioides L. The chemical composition was determined using Gas Chromatography-Flame Ionization Detection and Gas Chromatography-Mass Spectrometry. In vitro evaluations were assessed by evaluating the inhibitory potentials on the activities of α-glucosidase and antioxidants. A total of 58 phytochemicals were identified belonging to 11 classes of substances, of which aliphatic hydrocarbons (38.25%), diterpenes (20.54%), esters (16.33%), triterpenes (11.91%), diverse functional groups (3.74%), aromatic hydrocarbons (2.64%), sesquiterpenes (2.31%), alcohols (1.41%), ketones (0.29%), monoterpenes (0.16%), and fatty acids (0.14%). The major compounds were heptacosane (30.48%) (46), phytol (20.94) (35), and squalene (11.07%) (56). The methanol extract and its fractions showed moderate α-glucosidase activity, but their IC50 values were lower than the positive control 1-deoxynojirimycin. However, the methanol and methanol-water fractions exhibited more scavenging activity on 2,2-diphenyl-1-picrylhydrazyl with IC50 values similar to butylated hydroxyanisole (BHA). The plant is rich in various phytoconstituents, and its α-glucosidase and antioxidant status may justify its use in traditional medicine, especially for preventing complications of diabetes.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131261701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The development of new drugs is a long-term and expensive process. Among the strategies to find out new drugs, natural products have an important role in providing new drugs and prototypes. However, physicochemical and pharmacokinetics properties demand chemical optimization for many natural products to improve their safety and efficacy. Molecular modifications (MM) represent a successful approach to optimising such properties. Here, we describe the use of MM to enhance the properties of resveratrol. Thus, we described some strategies to find new resveratrol derivatives useful as sunscreen and treat sickle cell disease. Some examples are described, showing the role of MM in discovering new bioactive compounds.
{"title":"The multiple biological effects of new resveratrol derivatives","authors":"João Lucas Bruno Prates, J. D. dos Santos","doi":"10.53365/nrfhh/156437","DOIUrl":"https://doi.org/10.53365/nrfhh/156437","url":null,"abstract":"The development of new drugs is a long-term and expensive process. Among the strategies to find out new drugs, natural products have an important role in providing new drugs and prototypes. However, physicochemical and pharmacokinetics properties demand chemical optimization for many natural products to improve their safety and efficacy. Molecular modifications (MM) represent a successful approach to optimising such properties. Here, we describe the use of MM to enhance the properties of resveratrol. Thus, we described some strategies to find new resveratrol derivatives useful as sunscreen and treat sickle cell disease. Some examples are described, showing the role of MM in discovering new bioactive compounds.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122731857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The hepatoprotective potential of grape and polyphenols has been scientifically well demonstrated in several experimental studies. However, there is no systematic review performed on their hepatoprotective activity. Based on scientific evidence, the goal of this systematic review was to describe and make inferences on the therapeutic advantages of grape and polyphenols against various chemical hepatotoxicities. Grape and polyphenols from preclinical and clinical studies were included for the online search utilising electronic databases such as PubMed, Web of Science, Scopus, Springer Nature, and Google Scholar. The searched words and terms were: “Hepatotoxicity” OR “Hepatoprotective” OR “Liver injury” AND “Hepatotoxic drug” AND “Grape” OR “Grapefruit” OR “Grape seed” OR “Grape peels” OR “Bioactive compounds” OR “Polyphenols” AND “Preclinical studies” OR “Clinical studies”. A total of sixty-five studies were included based on the rigorous inclusion and exclusion criteria. The systematic review revealed that grape and polyphenolic compounds could significantly alleviate hepatic markers (ALP, ALT and AST), antioxidant status (CAT, GPx, GSH and SOD), hepatic anti-inflammatory status (TNF-α, IL-1, IL-6, COX-2, and NF-κB pathways) and apoptosis markers [caspase-3 (CASP) and caspase-9] in chemical induced-hepatotoxicity. Furthermore, improvements in the structural, functional, and physiological characteristics of the liver were observed after treatment with grape and polyphenols, reflecting modulation in the cellular and molecular alterations. Conclusively, this study supports the therapeutic potential of grape and polyphenols for the management of hepatotoxicity in various conditions based on available scientific evidence.
葡萄和多酚的肝保护潜力已经在一些实验研究中得到了很好的科学证明。然而，没有对其肝保护活性进行系统评价。基于科学证据，本系统综述的目的是描述和推断葡萄和多酚对各种化学肝毒性的治疗优势。利用PubMed、Web of Science、Scopus、b施普林格Nature和谷歌Scholar等电子数据库进行在线搜索，包括临床前和临床研究中的葡萄和多酚。搜索的关键词和术语是:“肝毒性”或“保肝”或“肝损伤”、“肝毒性药物”、“葡萄”或“葡萄柚”或“葡萄籽”或“葡萄皮”或“生物活性化合物”或“多酚”和“临床前研究”或“临床研究”。根据严格的纳入和排除标准，共纳入65项研究。系统评价显示，葡萄和多酚类化合物可显著缓解化学诱导肝毒性的肝脏标志物(ALP、ALT和AST)、抗氧化状态(CAT、GPx、GSH和SOD)、肝脏抗炎状态(TNF-α、IL-1、IL-6、COX-2和NF-κB通路)和凋亡标志物[caspase-3 (CASP)和caspase-9]。此外，在葡萄和多酚处理后，肝脏的结构、功能和生理特性得到改善，反映了细胞和分子改变的调节。最后，根据现有的科学证据，本研究支持葡萄和多酚在各种情况下对肝毒性管理的治疗潜力。
{"title":"A systematic review on hepatoprotective potential of grape and polyphenolic compounds: molecular mechanism and future prospective","authors":"Shabina Khan, M. Ibrahim","doi":"10.53365/nrfhh/156261","DOIUrl":"https://doi.org/10.53365/nrfhh/156261","url":null,"abstract":"The hepatoprotective potential of grape and polyphenols has been scientifically well demonstrated in several experimental studies. However, there is no systematic review performed on their hepatoprotective activity. Based on scientific evidence, the goal of this systematic review was to describe and make inferences on the therapeutic advantages of grape and polyphenols against various chemical hepatotoxicities. Grape and polyphenols from preclinical and clinical studies were included for the online search utilising electronic databases such as PubMed, Web of Science, Scopus, Springer Nature, and Google Scholar. The searched words and terms were: “Hepatotoxicity” OR “Hepatoprotective” OR “Liver injury” AND “Hepatotoxic drug” AND “Grape” OR “Grapefruit” OR “Grape seed” OR “Grape peels” OR “Bioactive compounds” OR “Polyphenols” AND “Preclinical studies” OR “Clinical studies”. A total of sixty-five studies were included based on the rigorous inclusion and exclusion criteria. The systematic review revealed that grape and polyphenolic compounds could significantly alleviate hepatic markers (ALP, ALT and AST), antioxidant status (CAT, GPx, GSH and SOD), hepatic anti-inflammatory status (TNF-α, IL-1, IL-6, COX-2, and NF-κB pathways) and apoptosis markers [caspase-3 (CASP) and caspase-9] in chemical induced-hepatotoxicity. Furthermore, improvements in the structural, functional, and physiological characteristics of the liver were observed after treatment with grape and polyphenols, reflecting modulation in the cellular and molecular alterations. Conclusively, this study supports the therapeutic potential of grape and polyphenols for the management of hepatotoxicity in various conditions based on available scientific evidence.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130277216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fedoua Ben Rejeb, H. Chograni, Mériam Ben Romdhane, L. Riahi
Artemisia arborescens L., well known as tree wormwood, is a medicinal species of the Asteraceae family that makes a part of the folk medicine system in the Mediterranean regions. Several scientific studies have validated the traditional medicinal use of tree wormwood and confirmed its antimicrobial, anti-tumor, antioxidant, anti-inflammatory and hepatoprotective properties. In this study, the incidence of two abiotic elicitors (NaCl and KCl) on the concentration and bioactivity of secondary metabolites in tree wormwood microshoots regenerated in vitro was evaluated. The obtained results showed that the application of 100 mM NaCl or KCl to one-month old in vitro developed microshoots resulted in the enhancement of the accumulation of total polyphenols, flavonoids, condensed tannins and volatile compounds. The highest improvement rates of total polyphenols (80%) and flavonoids (53%) over the control were obtained with NaCl elicitor. However, KCl elicitor has been shown more efficient in the enhancement of condensed tannins (430%) and volatile metabolites (39%) contents. The application of the two salt elicitors led also to a significant increase of the antioxidant activities of ethanolic and volatile metabolites extracts in the treated microshoots. The obtained results are promising and further detailed investigations are needed for the optimization of this strategy to improve the in vitro production of Artemisia arborescens L. phytochemicals with high potentialities in alternative medicine and pharmaceutical industry.
艾草(Artemisia arborescens L.)是菊科的一种药用植物，是地中海地区民间医药体系的一部分。多项科学研究证实了艾草的传统药用价值，并证实了其抗菌、抗肿瘤、抗氧化、抗炎和保护肝脏的特性。研究了两种非生物激发子(NaCl和KCl)对艾草离体再生微梢次生代谢产物浓度和生物活性的影响。结果表明，100 mM NaCl或KCl处理月龄离体发育微芽，可促进总多酚、总黄酮、缩合单宁和挥发性化合物的积累。NaCl激发剂对总多酚(80%)和总黄酮(53%)的提高率最高。然而，KCl激发子在提高浓缩单宁(430%)和挥发性代谢物(39%)含量方面更有效。两种盐激发剂的应用也导致处理过的微芽中乙醇和挥发性代谢物提取物的抗氧化活性显著增加。本研究结果具有广阔的应用前景，为进一步优化这一策略，提高在替代医学和制药工业中具有较大潜力的青蒿植物化学物质的体外生产水平，还需进一步深入研究。
{"title":"Effects of two abiotic elicitors on secondary metabolites accumulation and bioactivity in tree wormwood in vitro shoot cultures","authors":"Fedoua Ben Rejeb, H. Chograni, Mériam Ben Romdhane, L. Riahi","doi":"10.53365/nrfhh/154953","DOIUrl":"https://doi.org/10.53365/nrfhh/154953","url":null,"abstract":"Artemisia arborescens L., well known as tree wormwood, is a medicinal species of the Asteraceae family that makes a part of the folk medicine system in the Mediterranean regions. Several scientific studies have validated the traditional medicinal use of tree wormwood and confirmed its antimicrobial, anti-tumor, antioxidant, anti-inflammatory and hepatoprotective properties. In this study, the incidence of two abiotic elicitors (NaCl and KCl) on the concentration and bioactivity of secondary metabolites in tree wormwood microshoots regenerated in vitro was evaluated. The obtained results showed that the application of 100 mM NaCl or KCl to one-month old in vitro developed microshoots resulted in the enhancement of the accumulation of total polyphenols, flavonoids, condensed tannins and volatile compounds. The highest improvement rates of total polyphenols (80%) and flavonoids (53%) over the control were obtained with NaCl elicitor. However, KCl elicitor has been shown more efficient in the enhancement of condensed tannins (430%) and volatile metabolites (39%) contents. The application of the two salt elicitors led also to a significant increase of the antioxidant activities of ethanolic and volatile metabolites extracts in the treated microshoots. The obtained results are promising and further detailed investigations are needed for the optimization of this strategy to improve the in vitro production of Artemisia arborescens L. phytochemicals with high potentialities in alternative medicine and pharmaceutical industry.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126256436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our search for antimicrobial and cytotoxic leads from Ficus sycomorus led to the isolation of twenty-four known compounds (1‒24) from its methanolic stem bark and root extracts. The structures of all the isolated compounds were established using their 1D- and 2D-NMR spectroscopic data while the crude extracts, some fractions and compounds were tested for their antibacterial, antifungal and cytotoxicity activities. In the antimicrobial assay, compound 18 displayed good to moderate activity with MIC values of 31.25 µg/ml against Escherichia coli, 125 µg/ml against Salmonella typhimurium cpc and Pseudomonas aeruginosa, while compounds 10, 13 and 14 demonstrated moderate activities on almost all the tested strains, with the highest potency observed for compound 13 on E. coli (MIC = 125 µg/ml). However, although compounds 18 and 19 gave a significant inhibition of the VERO cell line ATCC CRT-1586 with CC50 values of 52.60 µg/ml and 69.10 µg/ml, respectively, all the extract samples and other tested compounds did not show distinguishable cytotoxicity. Finally, the chemophenetic significance of the isolated compounds is discussed.
{"title":"Antimicrobial and cytotoxic extractives from Ficus sycomorus L. (Moraceae)","authors":"Vanini Samiyatou Michiren Mandou, Willifred Dongmo Tekapi Tsopgni, Mohamed Foundikou Nsangou, Gervais Mouthé Happi, A. F. Kamdem Waffo, Emmanuel Ngeufa Happi","doi":"10.53365/nrfhh/155330","DOIUrl":"https://doi.org/10.53365/nrfhh/155330","url":null,"abstract":"Our search for antimicrobial and cytotoxic leads from Ficus sycomorus led to the isolation of twenty-four known compounds (1‒24) from its methanolic stem bark and root extracts. The structures of all the isolated compounds were established using their 1D- and 2D-NMR spectroscopic data while the crude extracts, some fractions and compounds were tested for their antibacterial, antifungal and cytotoxicity activities. In the antimicrobial assay, compound 18 displayed good to moderate activity with MIC values of 31.25 µg/ml against Escherichia coli, 125 µg/ml against Salmonella typhimurium cpc and Pseudomonas aeruginosa, while compounds 10, 13 and 14 demonstrated moderate activities on almost all the tested strains, with the highest potency observed for compound 13 on E. coli (MIC = 125 µg/ml). However, although compounds 18 and 19 gave a significant inhibition of the VERO cell line ATCC CRT-1586 with CC50 values of 52.60 µg/ml and 69.10 µg/ml, respectively, all the extract samples and other tested compounds did not show distinguishable cytotoxicity. Finally, the chemophenetic significance of the isolated compounds is discussed.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126547519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanoy Mazumder, Md. Abdus Salam, Shuvo Mitra, S. Hossain, M. Hussain
Thrombosis-associated cardiovascular and cerebrovascular disorders are the leading causes of global mortality and morbidity; this rate is alarmingly rising. A diverse class of antithrombotic drugs like antiplatelet and anticoagulant agents are frequently used to manage thrombus-induced physiological consequences, including cardiovascular and cerebrovascular diseases. But these agents have reported producing a series of adverse effects on the body, including potential bleeding episodes, which makes it urgent to discover antithrombotic therapy with higher efficacy, novel mechanisms of action, and fewer side effects. Research is still going on to isolate antithrombotic agents from various natural sources, and researchers are making remarkable progress in this field. In different experimental models, medicinal plant extracts and plant-derived bioactive compounds have been documented to produce antithrombotic activity through mechanisms like conventional drugs, with minimal or no side effects. Plant extracts and their bioactive compounds (phenolics, polysaccharides, peptides, terpenes, flavonoids) have proven their efficacy as potential candidates for developing safe antithrombotic therapy in numerous in vivo and in vitro models. Our review aims to introduce the readers to the relationship between thrombus formation and cardiovascular diseases (CVDs), problems with traditional therapies, and the role of natural resources in managing thrombus-induced cardiovascular and cerebrovascular diseases with possible mechanisms.
{"title":"Current antithrombotic therapies and prospects of natural compounds in the management of the thrombotic disorder","authors":"Tanoy Mazumder, Md. Abdus Salam, Shuvo Mitra, S. Hossain, M. Hussain","doi":"10.53365/nrfhh/154960","DOIUrl":"https://doi.org/10.53365/nrfhh/154960","url":null,"abstract":"Thrombosis-associated cardiovascular and cerebrovascular disorders are the leading causes of global mortality and morbidity; this rate is alarmingly rising. A diverse class of antithrombotic drugs like antiplatelet and anticoagulant agents are frequently used to manage thrombus-induced physiological consequences, including cardiovascular and cerebrovascular diseases. But these agents have reported producing a series of adverse effects on the body, including potential bleeding episodes, which makes it urgent to discover antithrombotic therapy with higher efficacy, novel mechanisms of action, and fewer side effects. Research is still going on to isolate antithrombotic agents from various natural sources, and researchers are making remarkable progress in this field. In different experimental models, medicinal plant extracts and plant-derived bioactive compounds have been documented to produce antithrombotic activity through mechanisms like conventional drugs, with minimal or no side effects. Plant extracts and their bioactive compounds (phenolics, polysaccharides, peptides, terpenes, flavonoids) have proven their efficacy as potential candidates for developing safe antithrombotic therapy in numerous in vivo and in vitro models. Our review aims to introduce the readers to the relationship between thrombus formation and cardiovascular diseases (CVDs), problems with traditional therapies, and the role of natural resources in managing thrombus-induced cardiovascular and cerebrovascular diseases with possible mechanisms.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"134 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131049452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ibrahim, R. Tiwari, Mohammad Fahim, Sadique Nirban
{"title":"Withdrawal notice to \"Integrating phytochemical profiling, in vitro studies and network pharmacology to reveal the antidiabetic action mechanism of Punica granatum fruit peel\"","authors":"M. Ibrahim, R. Tiwari, Mohammad Fahim, Sadique Nirban","doi":"10.53365/nrfhh/155370","DOIUrl":"https://doi.org/10.53365/nrfhh/155370","url":null,"abstract":"","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"166 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124658390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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