Akilandeswari Govindraj, M. Ramasamy, Velayuthapraphu Shanmugam, S. Muthukrishnan, B. Balasubramanian, V. Arumugam
The present investigation aimed to identify the effects of ethanolic extract of Andrographis paniculata Linn. and Rhinacanthus nasutus Kurz. on enzymatic and non-enzymatic antioxidants on isoniazid and rifampicin induced Wistar rats. Animals were randomly divided into nine groups of 6 rats each and housed in individually ventilated cages for further experimental procedure. The levels of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-s-transfersase (GST), lipid peroxides (LPO), reduced glutathione (GSH), vitamin C (vit C) and vitamin E (vit E) and carbohydrate metabolism parameters of glucose, glycogen, glucose-6-phosphatase, glucose-6-phosphatase dehydrogenase and hexokinase are estimated at the end of the study. The present study results highlighted that the leaves extract of A. paniculata and R. nasutus have an antioxidant effect and anti-diabetic activity against the toxin treated rats.
{"title":"Antioxidant and antidiabetic activity of Andrographis paniculata and Rhinacanthus nasutus in isoniazid and rifampicin induced Wistar rats","authors":"Akilandeswari Govindraj, M. Ramasamy, Velayuthapraphu Shanmugam, S. Muthukrishnan, B. Balasubramanian, V. Arumugam","doi":"10.53365/nrfhh/147427","DOIUrl":"https://doi.org/10.53365/nrfhh/147427","url":null,"abstract":"The present investigation aimed to identify the effects of ethanolic extract of Andrographis paniculata Linn. and Rhinacanthus nasutus Kurz. on enzymatic and non-enzymatic antioxidants on isoniazid and rifampicin induced Wistar rats. Animals were randomly divided into nine groups of 6 rats each and housed in individually ventilated cages for further experimental procedure. The levels of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-s-transfersase (GST), lipid peroxides (LPO), reduced glutathione (GSH), vitamin C (vit C) and vitamin E (vit E) and carbohydrate metabolism parameters of glucose, glycogen, glucose-6-phosphatase, glucose-6-phosphatase dehydrogenase and hexokinase are estimated at the end of the study. The present study results highlighted that the leaves extract of A. paniculata and R. nasutus have an antioxidant effect and anti-diabetic activity against the toxin treated rats.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116171792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Klev Gaïtan Sikam, Virginia Kien Ntabo, Happi Mouthe Gervais, Livine Zemo Meikeu, J. Wansi
Aridanin, a triterpenoid N-acetylglycoside has been obtained from chemical investigations of the root of Tetrapleura tetraptera, a well-known seasoning spice from Cameroonian food. The structure of the compound has been established using its NMR data and by comparison of that data with the one reported in the literature. Further evidence has been compiled from literature and discussed on the occurrence, the extraction, isolation and analytical techniques as well as the reported biological activities of aridanin. Based on its potency and its high yield in Tetrapleura tetraptera fruits, the compound can be considered as lead compound in the development of medicine for the control of schistosomiasis and bacterial infections caused by the bacterial strainsE. coli, E. smartii and E. aeroginese. this paper sheds light on the compound aridanin which deserves more attention in the development of a new potent drug or on the formulation of Tetrapleura tetraptera for effective use by the local population.
{"title":"Chemistry and pharmacological aspects of Aridanin, a lead compound from Tetrapleura tetraptera (Fabaceae)","authors":"Klev Gaïtan Sikam, Virginia Kien Ntabo, Happi Mouthe Gervais, Livine Zemo Meikeu, J. Wansi","doi":"10.53365/nrfhh/152273","DOIUrl":"https://doi.org/10.53365/nrfhh/152273","url":null,"abstract":"Aridanin, a triterpenoid N-acetylglycoside has been obtained from chemical investigations of the root of Tetrapleura tetraptera, a well-known seasoning spice from Cameroonian food. The structure of the compound has been established using its NMR data and by comparison of that data with the one reported in the literature. Further evidence has been compiled from literature and discussed on the occurrence, the extraction, isolation and analytical techniques as well as the reported biological activities of aridanin. Based on its potency and its high yield in Tetrapleura tetraptera fruits, the compound can be considered as lead compound in the development of medicine for the control of schistosomiasis and bacterial infections caused by the bacterial strainsE. coli, E. smartii and E. aeroginese. this paper sheds light on the compound aridanin which deserves more attention in the development of a new potent drug or on the formulation of Tetrapleura tetraptera for effective use by the local population.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116555376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mouthe Gervais Happi, Virginia Kien Ntabo, Désiré Soh, J. Wansi
Streptomyces are bacteria of great importance for several decades. Numerous potent metabolites characterized as antibiotics including macrolides and polypetides have been reported from Streptomyces and developed as effective drugs for the treatment of several illnesses. Therefore, Streptomyces can be considered as an important source of bioactive compounds which might help in the eradication of malaria which remains one of the greatest threats to human life, especially in the tropical and sub-tropical regions. The reported in vitro antiplasmodial properties of chemical constituents from Streptomyces strains have led to promising results like bafilomycin A1 (9), concanamycin A (10), elaiophylin (17), cyclomarin C (23), urdamycinone E (44), geldanamycin (52) and metacycloprodigiosin (74) which individually exhibited strong antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 with IC50 values of 0.041 μg/ml, 0.2 nM, 0.22 μg/ml, 0.24 μg/ml, 0.0534 μg/ml, 0.35 μg/ml and 0.0050 μg/ml, respectively. In some cases, the tested compound was most active than the reference and without observed toxicity until the highest concentration. However, more in vivo and toxicity studies are necessary for further guidance in the process of drug development. To the best of our knowledge, no specific review has been done on the potential of Streptomyces in furnishing antiplasmodial compounds for malaria control. This paper aims to compile the literature up to 2021 on antiplasmodial compounds isolated from Streptomyces for easy and rapid access to the literature for further investigations in continuity.
{"title":"Potential of Streptomyces in producing antiplasmodial lead compounds","authors":"Mouthe Gervais Happi, Virginia Kien Ntabo, Désiré Soh, J. Wansi","doi":"10.53365/nrfhh/150397","DOIUrl":"https://doi.org/10.53365/nrfhh/150397","url":null,"abstract":"Streptomyces are bacteria of great importance for several decades. Numerous potent metabolites characterized as antibiotics including macrolides and polypetides have been reported from Streptomyces and developed as effective drugs for the treatment of several illnesses. Therefore, Streptomyces can be considered as an important source of bioactive compounds which might help in the eradication of malaria which remains one of the greatest threats to human life, especially in the tropical and sub-tropical regions. The reported in vitro antiplasmodial properties of chemical constituents from Streptomyces strains have led to promising results like bafilomycin A1 (9), concanamycin A (10), elaiophylin (17), cyclomarin C (23), urdamycinone E (44), geldanamycin (52) and metacycloprodigiosin (74) which individually exhibited strong antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 with IC50 values of 0.041 μg/ml, 0.2 nM, 0.22 μg/ml, 0.24 μg/ml, 0.0534 μg/ml, 0.35 μg/ml and 0.0050 μg/ml, respectively. In some cases, the tested compound was most active than the reference and without observed toxicity until the highest concentration. However, more in vivo and toxicity studies are necessary for further guidance in the process of drug development. To the best of our knowledge, no specific review has been done on the potential of Streptomyces in furnishing antiplasmodial compounds for malaria control. This paper aims to compile the literature up to 2021 on antiplasmodial compounds isolated from Streptomyces for easy and rapid access to the literature for further investigations in continuity.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115192365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justicia gendarussa Burm f., a member of Acanthaceae family, is indigenous to China and is widely dispersed throughout India, including the Andaman and Nicobar Islands. J. gendarussa is one of the most important plant species utilised in Ayurveda and Chinese medicine. Typically the plants are employed for different medicinal purposes. The plant possesses diverse biological activities like antiangiogenic, antibacterial, hepatoprotection, antifungal, antidepressant, sedative-hypnotic, anxiolytic, immunosuppressant, cytotoxicity, antioxidant and anthelmintic activities. Various chemical elements such as carbohydrates, alkaloids, polyphenolic chemicals, steroids, terpenoids, and saponins have been identified to contribute to these functions. The leaves were found to own most of the constituents like lupeol, friedelin, ß-sitosterol and aromatic amines. The current review emphases on Justicia gendarussa Burm's ethnobotanical significance, bioactive ingredients, and pharmacological profile.
{"title":"Bioactive constituents and pharmacological profile of willow-leaved Justicia: A review","authors":"Priyanka Roy, Litty Joseph","doi":"10.53365/nrfhh/146769","DOIUrl":"https://doi.org/10.53365/nrfhh/146769","url":null,"abstract":"Justicia gendarussa Burm f., a member of Acanthaceae family, is indigenous to China and is widely dispersed throughout India, including the Andaman and Nicobar Islands. J. gendarussa is one of the most important plant species utilised in Ayurveda and Chinese medicine. Typically the plants are employed for different medicinal purposes. The plant possesses diverse biological activities like antiangiogenic, antibacterial, hepatoprotection, antifungal, antidepressant, sedative-hypnotic, anxiolytic, immunosuppressant, cytotoxicity, antioxidant and anthelmintic activities. Various chemical elements such as carbohydrates, alkaloids, polyphenolic chemicals, steroids, terpenoids, and saponins have been identified to contribute to these functions. The leaves were found to own most of the constituents like lupeol, friedelin, ß-sitosterol and aromatic amines. The current review emphases on Justicia gendarussa Burm's ethnobotanical significance, bioactive ingredients, and pharmacological profile.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116625450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. C. Marcelino, Leonardo Pereira de Araújo, João Bueno de Morais Borba, N. J. F. da Silveira
At the end of 2019, atypical cases of pneumonia accompanied by particular symptoms started being reported in the Chinese city of Wuhan. After a few weeks had passed, the aforementioned disease spread throughout China and became a global pandemic some months later. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the etiological agent of that atypical pneumonia, which has been named Coronavirus Disease 2019 (COVID-19). In an attempt to find an efficient therapy to either fight the spread of COVID-19 or to cure infected people from its tissue damages, researchers around the world have been studying several plants, herbs and natural products. These potential medicines have been used for therapeutic purposes throughout the years due to the great variety of bioactive compounds characterizing them. The present work aimed to perform virtual screenings by using AutoDock Vina software to execute molecular docking studies of tridimensional (3D) structures of well-known bioactive natural compounds against 24 SARS-CoV-2 proteins. We have analyzed energy scores (provided in -Kcal/mol) as well as ligand-protein intermolecular binding interactions. In vitro and in vivo assays should be furtherly conducted to corroborate with our findings and therefore validate chemical substances derived from plants and herbs, such as Punica granatum, Centella asiatica and Solanum spp., as promising drug candidates to either treat or prevent COVID-19.
{"title":"Molecular docking study involving bioactive natural compounds against SARS-CoV-2 proteins","authors":"R. C. Marcelino, Leonardo Pereira de Araújo, João Bueno de Morais Borba, N. J. F. da Silveira","doi":"10.53365/nrfhh/147375","DOIUrl":"https://doi.org/10.53365/nrfhh/147375","url":null,"abstract":"At the end of 2019, atypical cases of pneumonia accompanied by particular symptoms started being reported in the Chinese city of Wuhan. After a few weeks had passed, the aforementioned disease spread throughout China and became a global pandemic some months later. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the etiological agent of that atypical pneumonia, which has been named Coronavirus Disease 2019 (COVID-19). In an attempt to find an efficient therapy to either fight the spread of COVID-19 or to cure infected people from its tissue damages, researchers around the world have been studying several plants, herbs and natural products. These potential medicines have been used for therapeutic purposes throughout the years due to the great variety of bioactive compounds characterizing them. The present work aimed to perform virtual screenings by using AutoDock Vina software to execute molecular docking studies of tridimensional (3D) structures of well-known bioactive natural compounds against 24 SARS-CoV-2 proteins. We have analyzed energy scores (provided in -Kcal/mol) as well as ligand-protein intermolecular binding interactions. In vitro and in vivo assays should be furtherly conducted to corroborate with our findings and therefore validate chemical substances derived from plants and herbs, such as Punica granatum, Centella asiatica and Solanum spp., as promising drug candidates to either treat or prevent COVID-19.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129089681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article documents the first time isolation of Carissic acid from Neolamarckia cadamba (Roxb.) Bosser (Family: Rubiaceae) leaves. This bioactive triterpenic acid was isolated with a yield of 3.26% by ultrasonic waves. One-dimensional Nuclear Magnetic Resonance (NMR) spectroscopic techniques such as proton NMR (1H NMR), carbon-13 NMR (13C NMR), distortionless enhancement by polarisation transfer (DEPT), and two-dimensional NMR spectroscopic methods such as heteronuclear single quantum coherence (HSQC) were used to identify the structure. About 63.0 mg of pure carissic acid was isolated from 1.931 grams of acetone extract using sonomaceration as an extraction technique.
{"title":"Isolation and structural determination of ursane-type triterpene from Neolamarckia cadamba dried leaves","authors":"V. Patil, J. George, G. Meshram","doi":"10.53365/nrfhh/147428","DOIUrl":"https://doi.org/10.53365/nrfhh/147428","url":null,"abstract":"This article documents the first time isolation of Carissic acid from Neolamarckia cadamba (Roxb.) Bosser (Family: Rubiaceae) leaves. This bioactive triterpenic acid was isolated with a yield of 3.26% by ultrasonic waves. One-dimensional Nuclear Magnetic Resonance (NMR) spectroscopic techniques such as proton NMR (1H NMR), carbon-13 NMR (13C NMR), distortionless enhancement by polarisation transfer (DEPT), and two-dimensional NMR spectroscopic methods such as heteronuclear single quantum coherence (HSQC) were used to identify the structure. About 63.0 mg of pure carissic acid was isolated from 1.931 grams of acetone extract using sonomaceration as an extraction technique.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132704307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mawunu, Mazekanua H. G. Panzo, A. Telo, K. Ngbolua, Lukoki Luyeye, L. Ndiku, T. Lautenschläger
The forests and savannahs of Mucaba municipality in northern Angola hold enormous potential for plant-based non-timber forest products (NTFPs), including wild food plants (WFPs). Mucaba communities have accumulated a wealth of traditional knowledge on the use of wild edible plants over their long history. However, few studies have highlighted this unique and globally attractive culture. The ethnobotanical survey was conducted in 9 villages in Mucaba Municipality in September and October 2020. A total of 65 local informants were interviewed (35 women and 30 men), and their traditional knowledge of wild edible plants was documented. A total of 46 wild edible plants, belonging to 25 families and 30 genera were documented. These plants are consumed as wild edible vegetables, seasonal fruits, spice substitutes for tea, and forest alcoholic drinks. The traditional knowledge of wild edible plants held by the villagers of Mucaba is rich but is in danger of being lost among the younger generation. Therefore, the diversified cultivation of these local plants would allow their sustainable use and conservation especially of the endangered species in this part of Angola.
{"title":"Ethnobotanical uses of wild edible plants of Mucaba municipality, Angola","authors":"M. Mawunu, Mazekanua H. G. Panzo, A. Telo, K. Ngbolua, Lukoki Luyeye, L. Ndiku, T. Lautenschläger","doi":"10.53365/nrfhh/146436","DOIUrl":"https://doi.org/10.53365/nrfhh/146436","url":null,"abstract":"The forests and savannahs of Mucaba municipality in northern Angola hold enormous potential for plant-based non-timber forest products (NTFPs), including wild food plants (WFPs). Mucaba communities have accumulated a wealth of traditional knowledge on the use of wild edible plants over their long history. However, few studies have highlighted this unique and globally attractive culture. The ethnobotanical survey was conducted in 9 villages in Mucaba Municipality in September and October 2020. A total of 65 local informants were interviewed (35 women and 30 men), and their traditional knowledge of wild edible plants was documented. A total of 46 wild edible plants, belonging to 25 families and 30 genera were documented. These plants are consumed as wild edible vegetables, seasonal fruits, spice substitutes for tea, and forest alcoholic drinks. The traditional knowledge of wild edible plants held by the villagers of Mucaba is rich but is in danger of being lost among the younger generation. Therefore, the diversified cultivation of these local plants would allow their sustainable use and conservation especially of the endangered species in this part of Angola.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128265135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Farhad Hossain, A. Afroz, Md. Shoaib Arifin, M. Begum, M. F. Jubayer
Aside from saving lives and restoring health, healthcare operations can result in the generation of hazardous biomedical wastes (BMW) that are harmful to humans and to the environment. The generation and disposal of BMW has emerged as a global issue. BMW management success is highly reliant on the knowledge, attitude, and practices (KAP) of healthcare individuals, and there is a scarcity of such works in the Bangladesh setting. This study was conducted to assess the KAP as well as the associated factors influencing knowledge on BMW management among hospital health care professionals (HCPs) in Cumilla, Bangladesh. This was a cross-sectional study. A total of 374 responses were collected for this study between January and April of 2019. The questionnaire was divided into four sections: socio-demographic data, BMW management knowledge and attitude, as well as an observational questionnaire evaluating HCPs' practice on BMW management. Among the 374 respondents, 168 HCPs used to have satisfactory knowledge with an overall mean score of 6.8±1.2. A high mean score (7.3 ± 1.4) was obtained by the doctors followed by the nurses (6.7 ± 1.6). The attitude was also positive, but the practice was found to be inadequate. A statistically significant (p<0.05) relationship was discovered between knowledge level and educational qualification, gender, work experience. The importance of educating and training all HCPs on proper BMW management should be emphasized.
{"title":"Factors associated with the current state of biomedical waste management knowledge, attitude, and practices among the healthcare professionals at a tertiary level hospital in Cumilla, Bangladesh","authors":"Md. Farhad Hossain, A. Afroz, Md. Shoaib Arifin, M. Begum, M. F. Jubayer","doi":"10.53365/nrfhh/146613","DOIUrl":"https://doi.org/10.53365/nrfhh/146613","url":null,"abstract":"Aside from saving lives and restoring health, healthcare operations can result in the generation of hazardous biomedical wastes (BMW) that are harmful to humans and to the environment. The generation and disposal of BMW has emerged as a global issue. BMW management success is highly reliant on the knowledge, attitude, and practices (KAP) of healthcare individuals, and there is a scarcity of such works in the Bangladesh setting. This study was conducted to assess the KAP as well as the associated factors influencing knowledge on BMW management among hospital health care professionals (HCPs) in Cumilla, Bangladesh. This was a cross-sectional study. A total of 374 responses were collected for this study between January and April of 2019. The questionnaire was divided into four sections: socio-demographic data, BMW management knowledge and attitude, as well as an observational questionnaire evaluating HCPs' practice on BMW management. Among the 374 respondents, 168 HCPs used to have satisfactory knowledge with an overall mean score of 6.8±1.2. A high mean score (7.3 ± 1.4) was obtained by the doctors followed by the nurses (6.7 ± 1.6). The attitude was also positive, but the practice was found to be inadequate. A statistically significant (p<0.05) relationship was discovered between knowledge level and educational qualification, gender, work experience. The importance of educating and training all HCPs on proper BMW management should be emphasized.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122397101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gurupalraj Durai Muthu Mani, B. Balamuralikrishnan, R. Manikandan, P. Sampathkumar, M. Arun, Rengasamy R Lakshminarayanan, Wen-Chao Liu, A. Vijaya Anand
The present investigation was aimed to identify the potentiality of Euphorbia thymifolia Linn. and Euphorbia hirta Linn. leaf extract on the toxin-induced (carbon tetrachloride - CCl4) Albino Wistar rats. The animals were grouped into 7 categories including control (basal diet, G1), CCl4-induced (1.5 mL/kg, b.w., i.p.) (G2), G1 administrated with 300 mg/kg b.w., extract of E. thymifolia (G3) and E. hirta (G4), G2 administrated with 300 mg/kg b.w., extract of E. thymifolia (G5), E. hirta (G6), and standard drug (silymarin 25 mg/kg b.w.; G7) for 21-days trial period with each group contains 6 rats. The samples were collected and the following parameters including mitochondrial enzymes, different ATPase and lipid profiles were analyzed. The membrane-bound enzymes, the mitochondrial enzymes levels and the lipid profiles were reduced in the toxin-induced rats but the levels of enzymes were restored, significantly increased and lipid profiles are returned to the normal in the treatment of both extracts.
{"title":"Effects of Euphorbia thymifolia and Euphorbia hirta leaf extracts on membrane-bound, mitochondrial enzymes and lipid profile of carbon tetrachloride-induced hepatotoxicity in rats","authors":"Gurupalraj Durai Muthu Mani, B. Balamuralikrishnan, R. Manikandan, P. Sampathkumar, M. Arun, Rengasamy R Lakshminarayanan, Wen-Chao Liu, A. Vijaya Anand","doi":"10.53365/nrfhh/146770","DOIUrl":"https://doi.org/10.53365/nrfhh/146770","url":null,"abstract":"The present investigation was aimed to identify the potentiality of Euphorbia thymifolia Linn. and Euphorbia hirta Linn. leaf extract on the toxin-induced (carbon tetrachloride - CCl4) Albino Wistar rats. The animals were grouped into 7 categories including control (basal diet, G1), CCl4-induced (1.5 mL/kg, b.w., i.p.) (G2), G1 administrated with 300 mg/kg b.w., extract of E. thymifolia (G3) and E. hirta (G4), G2 administrated with 300 mg/kg b.w., extract of E. thymifolia (G5), E. hirta (G6), and standard drug (silymarin 25 mg/kg b.w.; G7) for 21-days trial period with each group contains 6 rats. The samples were collected and the following parameters including mitochondrial enzymes, different ATPase and lipid profiles were analyzed. The membrane-bound enzymes, the mitochondrial enzymes levels and the lipid profiles were reduced in the toxin-induced rats but the levels of enzymes were restored, significantly increased and lipid profiles are returned to the normal in the treatment of both extracts.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116225514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thevetia peruviana is a large flowering shrub in the Apocynaceae family used medicinally. The current study aims to determine the phytochemicals and antimicrobial potential of T. peruviana. GC-MS was used to screen the ethanol and n-hexane extracts. Leaf extracts (ethanol and hexane) revealed alkaloids, phenols, anthraquinones, cardiac glycosides, flavonoids, tannins, steroid glycosides, carbohydrates, proteins, terpenoids, terpenoids and fixed oils and fats. GC-MS analysis of the ethanol and hexane extract revealed 24 bioactive metabolites. T. peruviana leaf extracts inhibited tested pathogens at 50, 100, and 200 mg/ml concentrations. A plethora of secondary metabolites demonstrated promising pharmacological benefits. The bioactive chemicals are utilised to treat bacterial infections, cancer, diabetes, and inflammation. This study demonstrated the antibacterial activity of several plants used in traditional medicine.
{"title":"Antibacterial, phytochemical and GC-MS analysis of Thevetia peruviana extracts: An approach in drug formulation","authors":"G. Edo","doi":"10.53365/nrfhh/146543","DOIUrl":"https://doi.org/10.53365/nrfhh/146543","url":null,"abstract":"Thevetia peruviana is a large flowering shrub in the Apocynaceae family used medicinally. The current study aims to determine the phytochemicals and antimicrobial potential of T. peruviana. GC-MS was used to screen the ethanol and n-hexane extracts. Leaf extracts (ethanol and hexane) revealed alkaloids, phenols, anthraquinones, cardiac glycosides, flavonoids, tannins, steroid glycosides, carbohydrates, proteins, terpenoids, terpenoids and fixed oils and fats. GC-MS analysis of the ethanol and hexane extract revealed 24 bioactive metabolites. T. peruviana leaf extracts inhibited tested pathogens at 50, 100, and 200 mg/ml concentrations. A plethora of secondary metabolites demonstrated promising pharmacological benefits. The bioactive chemicals are utilised to treat bacterial infections, cancer, diabetes, and inflammation. This study demonstrated the antibacterial activity of several plants used in traditional medicine.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128011014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：