T. Sangeetha, A. Vijaya Anand, T. Nargis Begum, P. Karthika, M. Arun, B. Balamuralikrishnan
Coriandrum sativum L. is a potential herb that is commonly known as coriander or Chinese parsley is being possessed to have various medicinal properties. Almost all the parts of the herb have been examined for its effectiveness in various human diseases such as migraine, hypertension and diabetes specifically. The diseases considered for the current review are migraine, hypertension and diabetes, which are highly prevalent as well as major co-morbidity for other clinical conditions. The extracts of different parts of C. sativum have been identified to have roles in treating and managing migraine, hypertension and diabetes. The genetic inter-relationship of C. sativum with the diseases are also being discussed in this review. The literature surf was done in platforms for the journals life science and medicinal research using the keywords C. sativum, herbal medicine, anti-diabetic, anti-hypertensive, migraine, genetics etc. The results obtained through the clinical trials conducted by various researchers globally were satisfactorily acceptable in treating these diseases along with some other diseases to a certain extent, whereas the genetic studies were insignificant. Henceforth, the current literature review highlights the medicinal exploitation of C. sativum in accordance with the treatment and management of migraine, hypertension and diabetes.
{"title":"Medicinal Exploitation of Coriandrum sativum L.","authors":"T. Sangeetha, A. Vijaya Anand, T. Nargis Begum, P. Karthika, M. Arun, B. Balamuralikrishnan","doi":"10.53365/nrfhh/147312","DOIUrl":"https://doi.org/10.53365/nrfhh/147312","url":null,"abstract":"Coriandrum sativum L. is a potential herb that is commonly known as coriander or Chinese parsley is being possessed to have various medicinal properties. Almost all the parts of the herb have been examined for its effectiveness in various human diseases such as migraine, hypertension and diabetes specifically. The diseases considered for the current review are migraine, hypertension and diabetes, which are highly prevalent as well as major co-morbidity for other clinical conditions. The extracts of different parts of C. sativum have been identified to have roles in treating and managing migraine, hypertension and diabetes. The genetic inter-relationship of C. sativum with the diseases are also being discussed in this review. The literature surf was done in platforms for the journals life science and medicinal research using the keywords C. sativum, herbal medicine, anti-diabetic, anti-hypertensive, migraine, genetics etc. The results obtained through the clinical trials conducted by various researchers globally were satisfactorily acceptable in treating these diseases along with some other diseases to a certain extent, whereas the genetic studies were insignificant. Henceforth, the current literature review highlights the medicinal exploitation of C. sativum in accordance with the treatment and management of migraine, hypertension and diabetes.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126454056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Arumugam, B. Elanchezhian, Jayakumar Samidurai, K. Amirthaganesan
The emerging microbial infections and their resistance to the existing antibiotics lead to discovering novel compounds, primarily from medicinal plants with secondary metabolites having several bioactive potentials, including antioxidants. The current investigation aims to measure the antioxidant and antibacterial efficacy of ethanolic extracts from roots, stems, leaves and seeds of Cleome rutidosperma. The extracts were subjected to quantitative (total phenolic and flavonoid), qualitative phytochemical studies, and functional groups identification by FT-IR analysis. The extract of leaves showed the highest total antioxidant (54.21±1.56 mg ABAE/g), DPPH (62.92±1.94 mg GAEs/g), and FRAP (71.64±2.02 mg GAEs/g) activity among the all-tested parts. The antibacterial efficacy of extracts was determined by the microdilution bioassay method, which demonstrated that G(+ve) bacteria appear to be more susceptible to the crude extracts than G (-ve) bacteria. The qualitative phytochemical screening-detected alkaloids, flavonoids, phenols, sugars, proteins, saponins, sterols, tannins, and terpenoids. The leaves have the highest levels of phenolics (70.451.23 mg GAE/g DW) and flavonoids (32.261.12 mg RE/g DW) among the all-tested parts. The extracts' functional group was validated using the FT-IR spectra. Polyphenols, flavonoids, and tannins were identified in the crude extracts. These findings imply that C. rutidoserma could be a promising candidate for further research into infectious illness treatment and as a resource of novel antioxidants in nutraceutical and biopharmaceutical industries as a functional additive.
{"title":"Comparative antioxidant, antibacterial and phytochemical analysis of roots, stems, leaves and seeds from Cleome rutidosperma DC","authors":"R. Arumugam, B. Elanchezhian, Jayakumar Samidurai, K. Amirthaganesan","doi":"10.53365/nrfhh/146009","DOIUrl":"https://doi.org/10.53365/nrfhh/146009","url":null,"abstract":"The emerging microbial infections and their resistance to the existing antibiotics lead to discovering novel compounds, primarily from medicinal plants with secondary metabolites having several bioactive potentials, including antioxidants. The current investigation aims to measure the antioxidant and antibacterial efficacy of ethanolic extracts from roots, stems, leaves and seeds of Cleome rutidosperma. The extracts were subjected to quantitative (total phenolic and flavonoid), qualitative phytochemical studies, and functional groups identification by FT-IR analysis. The extract of leaves showed the highest total antioxidant (54.21±1.56 mg ABAE/g), DPPH (62.92±1.94 mg GAEs/g), and FRAP (71.64±2.02 mg GAEs/g) activity among the all-tested parts. The antibacterial efficacy of extracts was determined by the microdilution bioassay method, which demonstrated that G(+ve) bacteria appear to be more susceptible to the crude extracts than G (-ve) bacteria. The qualitative phytochemical screening-detected alkaloids, flavonoids, phenols, sugars, proteins, saponins, sterols, tannins, and terpenoids. The leaves have the highest levels of phenolics (70.451.23 mg GAE/g DW) and flavonoids (32.261.12 mg RE/g DW) among the all-tested parts. The extracts' functional group was validated using the FT-IR spectra. Polyphenols, flavonoids, and tannins were identified in the crude extracts. These findings imply that C. rutidoserma could be a promising candidate for further research into infectious illness treatment and as a resource of novel antioxidants in nutraceutical and biopharmaceutical industries as a functional additive.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122896212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study aimed to provide confirmatory status on traditional usage of Detarium microcapum against urinary and intestinal infections and serve as an alternative in fighting against multi-drug resistance. Hence, the determination of chemical constituents of stem bark using GC-MS because of its sensitivity and high resolving power in identifying compounds, and test the antibacterial potential of methanol crude extract on some bacteria associated with the diseases claimed to be treated by traditional healers. Bacterial isolates were collected, and zone of inhibition diameter (ZID), minimum inhibition concentration (MIC), minimum bactericidal concentration (MBC) and minimum bacteriostatic concentration (MBS) were conducted to determine antibacterial activity. At the same time, gas chromatography coupled with mass spectrometry (GC-MS) was used to identify the phytoconstituents. The mean ZID (mm) ranged from 17.3±21 to 20.0±35 mm and showed a statistical significance difference at P< 0.05 for S. aureus, E. coli, and K. pneumonia. The MIC ranged from 11.67±7.6 to 4.17±1.4 mg/L, MBS 16.67±5.8 to 5.00±00, MBC 20.0±00 to 5.0±00, in order of increasing concentrations. Inspection of the MBC/MIC ratio indicated a bactericidal effect across isolates. From the GC-MS analysis, twenty-six phytochemical constituents were identified, primarily fatty acids or their esters. Chemical constituents' from D. microcapum methanol crude extract were identified. The antibacterial activity of some compounds directly correlates with the bioactivity of the same isolated and tested elsewhere, from a different source, thus its potential and therefore supporting the claim for its traditional usage. The research recommends in-depth research toward identifying specific active compounds for public health solutions.
{"title":"Antibacterial and phytochemicals status of Detarium microcarpum (guill and perr) stem bark","authors":"M. Dahiru, Kolawole Saheed, T. Adamu","doi":"10.53365/nrfhh/145597","DOIUrl":"https://doi.org/10.53365/nrfhh/145597","url":null,"abstract":"The study aimed to provide confirmatory status on traditional usage of Detarium microcapum against urinary and intestinal infections and serve as an alternative in fighting against multi-drug resistance. Hence, the determination of chemical constituents of stem bark using GC-MS because of its sensitivity and high resolving power in identifying compounds, and test the antibacterial potential of methanol crude extract on some bacteria associated with the diseases claimed to be treated by traditional healers. Bacterial isolates were collected, and zone of inhibition diameter (ZID), minimum inhibition concentration (MIC), minimum bactericidal concentration (MBC) and minimum bacteriostatic concentration (MBS) were conducted to determine antibacterial activity. At the same time, gas chromatography coupled with mass spectrometry (GC-MS) was used to identify the phytoconstituents. The mean ZID (mm) ranged from 17.3±21 to 20.0±35 mm and showed a statistical significance difference at P< 0.05 for S. aureus, E. coli, and K. pneumonia. The MIC ranged from 11.67±7.6 to 4.17±1.4 mg/L, MBS 16.67±5.8 to 5.00±00, MBC 20.0±00 to 5.0±00, in order of increasing concentrations. Inspection of the MBC/MIC ratio indicated a bactericidal effect across isolates. From the GC-MS analysis, twenty-six phytochemical constituents were identified, primarily fatty acids or their esters. Chemical constituents' from D. microcapum methanol crude extract were identified. The antibacterial activity of some compounds directly correlates with the bioactivity of the same isolated and tested elsewhere, from a different source, thus its potential and therefore supporting the claim for its traditional usage. The research recommends in-depth research toward identifying specific active compounds for public health solutions.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"15 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134412783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ibrahim B. E. El Bashir, Maha Y. Kordofani, S. Yagi, A. Al-Atar, A. Qahtan, Eslam M. Abdel-Salam, A. Alkahtani, M. Al-Mansoub, A. A. Ahmed Ali, Ali M. Batah, G. Zengin
Fourteen plants endogenous to Sudan were selected to evaluate their total phenolic content, antioxidant, antimalarial and cytotoxicity potential in the present work. Extracts were prepared by maceration of each plant material in chloroform: methanol (C: M; 1:1 v/v) mixture. The antioxidant activity was determined by measuring the radical scavenging effects against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and ferric-reducing (FRAP) capacity. The antiplasmodial activity was determined using the NF54 strain of Plasmodium falciparum. Cytotoxicity was evaluated towards human colorectal carcinoma cell line (HCT-116), human hormone-sensitive and invasive breast cancer cell line (MCF-7), and human hormone-resistant breast cancer cell line (MDA-MB-231), in addition to endothelial normal EAhy-296 cell line. Results showed that the plants' total phenolic and flavonoid contents were variable. Of the 14 plant species, only Burnatia enneandra showed high in vitro antiplasmodial activity (IC50 5758 ɳg/mL). Some plants possessed considerable free radical scavenging ability and reducing power. Coccinia grandis fruit extract (IC50 13.23 ± 0.51 μg/mL) and Geigeria alata root extract (IC50 35.54 ± 0.27 μg/mL) displayed the highest DPPH and ABTS scavenging activity, respectively. Striga hermonthica whole plant extract exhibited the highest FRAP reducing power (107.15 ± 0.11 nmol Fe+2 eq./mg). At a 100 μg/mL concentration, Dioscorea hirtiflora bulb extract displayed the highest cytotoxicity (74.23 ± 03.72%), followed by Mitragyna inermis fruit extract (65.28 ± 04.60%) against HCT-116 cell line. Aerva javanica leaf extract showed toxicity to the MDA-MB-231 cell line (50.82 ± 07.46%) at 100 μg/mL. The current study results showed that endogenous medicinal plants might represent a rich source of natural antioxidant, antimalarial and antitumor agents.
{"title":"Antimalarial, cytotoxic and antioxidant activities of 14 medicinal plants from Sudan","authors":"Ibrahim B. E. El Bashir, Maha Y. Kordofani, S. Yagi, A. Al-Atar, A. Qahtan, Eslam M. Abdel-Salam, A. Alkahtani, M. Al-Mansoub, A. A. Ahmed Ali, Ali M. Batah, G. Zengin","doi":"10.53365/nrfhh/146223","DOIUrl":"https://doi.org/10.53365/nrfhh/146223","url":null,"abstract":"Fourteen plants endogenous to Sudan were selected to evaluate their total phenolic content, antioxidant, antimalarial and cytotoxicity potential in the present work. Extracts were prepared by maceration of each plant material in chloroform: methanol (C: M; 1:1 v/v) mixture. The antioxidant activity was determined by measuring the radical scavenging effects against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and ferric-reducing (FRAP) capacity. The antiplasmodial activity was determined using the NF54 strain of Plasmodium falciparum. Cytotoxicity was evaluated towards human colorectal carcinoma cell line (HCT-116), human hormone-sensitive and invasive breast cancer cell line (MCF-7), and human hormone-resistant breast cancer cell line (MDA-MB-231), in addition to endothelial normal EAhy-296 cell line. Results showed that the plants' total phenolic and flavonoid contents were variable. Of the 14 plant species, only Burnatia enneandra showed high in vitro antiplasmodial activity (IC50 5758 ɳg/mL). Some plants possessed considerable free radical scavenging ability and reducing power. Coccinia grandis fruit extract (IC50 13.23 ± 0.51 μg/mL) and Geigeria alata root extract (IC50 35.54 ± 0.27 μg/mL) displayed the highest DPPH and ABTS scavenging activity, respectively. Striga hermonthica whole plant extract exhibited the highest FRAP reducing power (107.15 ± 0.11 nmol Fe+2 eq./mg). At a 100 μg/mL concentration, Dioscorea hirtiflora bulb extract displayed the highest cytotoxicity (74.23 ± 03.72%), followed by Mitragyna inermis fruit extract (65.28 ± 04.60%) against HCT-116 cell line. Aerva javanica leaf extract showed toxicity to the MDA-MB-231 cell line (50.82 ± 07.46%) at 100 μg/mL. The current study results showed that endogenous medicinal plants might represent a rich source of natural antioxidant, antimalarial and antitumor agents.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129817509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed. Khattab, Zeinab Sayed, Rawan. Altaf, Noha Yasen, Ahmed Al Aiashy, Hajar Alfeqy, G. Khedr, Shurouk. Atef, D. Ezzat, Mohamed H Nafady
Antioxidants play a very crucial naturally role in our bodies. Still, unfortunately, that is not enough. We need to compensate for the shortage we face by increasing the dietary antioxidants as exogenous sources, especially when there is an exogenous factor-induced oxidative stress as with the medical radiology staff because how much ionizing radiation they are exposed to exceeds the primitive dose limit by the International Commission on Radiological Protection (ICRP). Thus, a suitable uptake of minerals, vitamins, and Combinations of dietary antioxidants through the daily diet and balanced it remains the promising approach without exceeding the uptakes doses that could reverse the positive effects of this approach. This review focuses on the present knowledge about dietary antioxidant sources, mechanisms, effects of the cell components. It critically investigates studies examining the effects of dietary antioxidant supplementation and its role among medical radiology workers.
{"title":"The prophylactic roles of dietary antioxidants for medical radiology workers: A mini-review","authors":"Mohamed. Khattab, Zeinab Sayed, Rawan. Altaf, Noha Yasen, Ahmed Al Aiashy, Hajar Alfeqy, G. Khedr, Shurouk. Atef, D. Ezzat, Mohamed H Nafady","doi":"10.53365/nrfhh/146248","DOIUrl":"https://doi.org/10.53365/nrfhh/146248","url":null,"abstract":"Antioxidants play a very crucial naturally role in our bodies. Still, unfortunately, that is not enough. We need to compensate for the shortage we face by increasing the dietary antioxidants as exogenous sources, especially when there is an exogenous factor-induced oxidative stress as with the medical radiology staff because how much ionizing radiation they are exposed to exceeds the primitive dose limit by the International Commission on Radiological Protection (ICRP). Thus, a suitable uptake of minerals, vitamins, and Combinations of dietary antioxidants through the daily diet and balanced it remains the promising approach without exceeding the uptakes doses that could reverse the positive effects of this approach. This review focuses on the present knowledge about dietary antioxidant sources, mechanisms, effects of the cell components. It critically investigates studies examining the effects of dietary antioxidant supplementation and its role among medical radiology workers.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134211708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Banerjee, Souvik Pal, P. K. Das Mohapatra, S. Samanta
Dengue fever is an infectious disease of the dengue virus. It becomes a severe problem, particularly prevalent in the tropics and the subtropical countries. The disease can make a life-threatening illness at any age of the people. Still, there is no definite treatment regimen for dengue infection. Nature is a vast reservoir of precious phytochemical substances that can be explored to develop new phytotherapeutics for dengue treatment. Using natural resources either directly as pharmaceuticals or as a structural base for chemical synthesis can optimize the development of new antiviral agents against dengue. In this paper, we have tried to determine the therapeutic potentialities of some natural products as the dengue antiviral agents through in silico study. We had studied the inhibitory pattern of five phytochemical components (baicalein, fisetin, fucoidan, hyperoside, β-carboline) against the dengue envelope protein of dengue virus serotype-2. Among the components, baicalein and β-carboline were the potential phytochemicals that can inhibit the early step of viral infection after binding with dengue envelope protein. Other phytochemicals did not show satisfactory results. This result will be helpful for the development of new medicines from natural resources.
{"title":"Preliminary identification of potential phytochemical components as antiviral agents against Dengue Virus 2: An in silico study","authors":"A. Banerjee, Souvik Pal, P. K. Das Mohapatra, S. Samanta","doi":"10.53365/nrfhh/145575","DOIUrl":"https://doi.org/10.53365/nrfhh/145575","url":null,"abstract":"Dengue fever is an infectious disease of the dengue virus. It becomes a severe problem, particularly prevalent in the tropics and the subtropical countries. The disease can make a life-threatening illness at any age of the people. Still, there is no definite treatment regimen for dengue infection. Nature is a vast reservoir of precious phytochemical substances that can be explored to develop new phytotherapeutics for dengue treatment. Using natural resources either directly as pharmaceuticals or as a structural base for chemical synthesis can optimize the development of new antiviral agents against dengue. In this paper, we have tried to determine the therapeutic potentialities of some natural products as the dengue antiviral agents through in silico study. We had studied the inhibitory pattern of five phytochemical components (baicalein, fisetin, fucoidan, hyperoside, β-carboline) against the dengue envelope protein of dengue virus serotype-2. Among the components, baicalein and β-carboline were the potential phytochemicals that can inhibit the early step of viral infection after binding with dengue envelope protein. Other phytochemicals did not show satisfactory results. This result will be helpful for the development of new medicines from natural resources.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132662173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although vaccines are successfully developed against Severe Acute Respiratory Syndrome Coronavirus-19 (COVID-19), and many anticancer, anti-malarial, antibiotic drugs have been repurposed against the disease, it has been just impossible to save valuable human lives in specific conditions. Therefore, medical care has been developed against COVID-19 but not fully able to save human life from the disease. As a result, the third wave is noticed in many countries. Preventive methods such as social distancing, wearing masks, and hand salinization have been accepted as the main strategies to break the chain of the disease. Due to the reduction in pollution under less or no industrial and vehicular operations, water and air ecosystems have been restored in an unseen manner. Especially, NO2, SO2 and particulate matters etc. modulated higher expression of angiotensin-converting enzyme 2, the receptor of Severe Acute Respiratory Syndrome Coronavirus -2 in humans have also been emphatically documented. Therefore, along with medical care, environmental protection (especially to regulate NO2 emissions) along with practicing COVID-19 guidelines is to be maintained fully to combat COVID-19 the disease. Human beings must use this knowledge and experience as a spotlight to save nature in current and future times.
{"title":"Human health care against COVID-19 via environmental management","authors":"B. Paital","doi":"10.53365/nrfhh/143833","DOIUrl":"https://doi.org/10.53365/nrfhh/143833","url":null,"abstract":"Although vaccines are successfully developed against Severe Acute Respiratory Syndrome Coronavirus-19 (COVID-19), and many anticancer, anti-malarial, antibiotic drugs have been repurposed against the disease, it has been just impossible to save valuable human lives in specific conditions. Therefore, medical care has been developed against COVID-19 but not fully able to save human life from the disease. As a result, the third wave is noticed in many countries. Preventive methods such as social distancing, wearing masks, and hand salinization have been accepted as the main strategies to break the chain of the disease. Due to the reduction in pollution under less or no industrial and vehicular operations, water and air ecosystems have been restored in an unseen manner. Especially, NO2, SO2 and particulate matters etc. modulated higher expression of angiotensin-converting enzyme 2, the receptor of Severe Acute Respiratory Syndrome Coronavirus -2 in humans have also been emphatically documented. Therefore, along with medical care, environmental protection (especially to regulate NO2 emissions) along with practicing COVID-19 guidelines is to be maintained fully to combat COVID-19 the disease. Human beings must use this knowledge and experience as a spotlight to save nature in current and future times.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130349397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blaise M. Mbembo, C. L. Inkoto, J. O. Amogu, C. Ashande, J. Nagahuedi, P. Mpiana, K. Ngbolua
The purpose of this mini-review was to summarize and update knowledge on the phytochemistry, pharmacology, and toxicity of Cola nitida, with the view of providing baseline data for herbal drug formulation. In January 2021, a non-exhaustive online search of relevant articles was carried out on the phytochemistry, pharmacology, and toxicology of C. nitida from scientifically well-established databases such as Science Direct, PubMed, Web of Science, Scopus, Google Scholar, and SciELO. The plant's scientific name as well as phytochemistry, pharmacology, pharmacognosy, bioactivity and toxicology were used as keywords. The chemical structures of the compounds isolated from this plant were drawn using ChemBioDraw Ultra 12.0 software. A literature survey has revealed that C. nitida is highly appreciated by African populations in various cultures, especially in West Africa. Phytochemical analyses showed that C. nitida contains interesting compounds like catechin, caffeine, epicatechin, polyphenols, alkaloids, tannins, saponins, bromelain, cardenolides, proanthocyanidins, triterpenes, glycosides, flavonoids, anthraquinones, steroids, anthocyanins, glycosides, alkaloids, etc. The presence of these phyto-compounds in the investigated plant species justifies its used as an antimicrobial, anti-malarial, anti-inflammatory, anti-diabetic, anti-coagulant agent. Thus, C. nitida could be used as a raw material for manufacturing efficient medication against various diseases, including sickle cell disease.
这篇小型综述的目的是总结和更新关于可乐的植物化学、药理学和毒性的知识，以期为草药配方提供基线数据。2021年1月，我们从科学完善的数据库(如Science Direct、PubMed、Web of Science、Scopus、Google Scholar和SciELO)中对C. nitida的植物化学、药理学和毒理学进行了非详尽的在线搜索。以该植物的学名、植物化学、药理学、生药学、生物活性和毒理学作为关键词。利用ChemBioDraw Ultra 12.0软件绘制该植物分离化合物的化学结构。一项文献调查显示，在不同的文化中，特别是在西非，非洲人对乳酸菌非常欣赏。植物化学分析表明，硝酸菌含有儿茶素、咖啡因、表儿茶素、多酚、生物碱、单宁、皂苷、菠萝蛋白酶、核桃苷、原花青素、三萜、苷类、黄酮类、蒽醌类、类固醇、花青素、苷类、生物碱等有趣的化合物。这些植物化合物在被调查植物物种中的存在证明了其作为抗菌，抗疟疾，抗炎，抗糖尿病，抗凝血剂的用途。因此，乳酸菌可以作为一种原料，用于制造有效的药物治疗各种疾病，包括镰状细胞病。
{"title":"Mini-review on the phyto-chemistry, pharmacology and toxicology of Cola nitida (Vent.) Schott & Endl. (Malvaceae): A medically interesting bio-resource of multiple purposes in Africa","authors":"Blaise M. Mbembo, C. L. Inkoto, J. O. Amogu, C. Ashande, J. Nagahuedi, P. Mpiana, K. Ngbolua","doi":"10.53365/nrfhh/145511","DOIUrl":"https://doi.org/10.53365/nrfhh/145511","url":null,"abstract":"The purpose of this mini-review was to summarize and update knowledge on the phytochemistry, pharmacology, and toxicity of Cola nitida, with the view of providing baseline data for herbal drug formulation. In January 2021, a non-exhaustive online search of relevant articles was carried out on the phytochemistry, pharmacology, and toxicology of C. nitida from scientifically well-established databases such as Science Direct, PubMed, Web of Science, Scopus, Google Scholar, and SciELO. The plant's scientific name as well as phytochemistry, pharmacology, pharmacognosy, bioactivity and toxicology were used as keywords. The chemical structures of the compounds isolated from this plant were drawn using ChemBioDraw Ultra 12.0 software. A literature survey has revealed that C. nitida is highly appreciated by African populations in various cultures, especially in West Africa. Phytochemical analyses showed that C. nitida contains interesting compounds like catechin, caffeine, epicatechin, polyphenols, alkaloids, tannins, saponins, bromelain, cardenolides, proanthocyanidins, triterpenes, glycosides, flavonoids, anthraquinones, steroids, anthocyanins, glycosides, alkaloids, etc. The presence of these phyto-compounds in the investigated plant species justifies its used as an antimicrobial, anti-malarial, anti-inflammatory, anti-diabetic, anti-coagulant agent. Thus, C. nitida could be used as a raw material for manufacturing efficient medication against various diseases, including sickle cell disease.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114221206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural palmitic acid is a pivotal saturated fatty acid used in many biochemical processes occurring in humans and diverse living creatures, as it is the most common natural long-chain carboxylic acid whose unrivaled amphiphilic sperm-like skeleton with the inert single 15-C aliphatic chain (tail or carrier) and the very active one carboxyl group (head) represent a rich reactive entity and carrier for several organic/medicinal chemistry and pharmaceutics applications with respect to drug design and formulation. Derivatives of 1,3,4-oxadiazoles along with their 1,3,4-thiadiazoles and 1,2,4-triazoles analogs exhibit a broad spectrum of substantial pharmacological activities. Agreeing with the well-known hybridization principles and incorporation norms in hybrid chemistry, if a substituted nitrogenous heterocyclic aromatic nucleus of the three aforementioned kinds is straightway attached to the simple straight palmitic acid backbone at the position of the carboxyl group, the produced molecules are supposed to be very bioactive. This research work reports for the first once the efficient design/synthesis and characterization/elucidation of four one-tailed nitrogen-containing heterocyclic derivatives of palmitic acid constructure, which introduce a novel biologically-important pharmacophore having biocompatible amphiphilic sperm-shaped heteroaromatic structure.
{"title":"Design, Synthesis, and Characterization of Novel Series of Pharmacologically-important Sperm-shaped Amphiphilic Heterocyclic Compounds derived from Natural Palmitic Acid","authors":"A. Rabie","doi":"10.53365/nrfhh/144888","DOIUrl":"https://doi.org/10.53365/nrfhh/144888","url":null,"abstract":"Natural palmitic acid is a pivotal saturated fatty acid used in many biochemical processes occurring in humans and diverse living creatures, as it is the most common natural long-chain carboxylic acid whose unrivaled amphiphilic sperm-like skeleton with the inert single 15-C aliphatic chain (tail or carrier) and the very active one carboxyl group (head) represent a rich reactive entity and carrier for several organic/medicinal chemistry and pharmaceutics applications with respect to drug design and formulation. Derivatives of 1,3,4-oxadiazoles along with their 1,3,4-thiadiazoles and 1,2,4-triazoles analogs exhibit a broad spectrum of substantial pharmacological activities. Agreeing with the well-known hybridization principles and incorporation norms in hybrid chemistry, if a substituted nitrogenous heterocyclic aromatic nucleus of the three aforementioned kinds is straightway attached to the simple straight palmitic acid backbone at the position of the carboxyl group, the produced molecules are supposed to be very bioactive. This research work reports for the first once the efficient design/synthesis and characterization/elucidation of four one-tailed nitrogen-containing heterocyclic derivatives of palmitic acid constructure, which introduce a novel biologically-important pharmacophore having biocompatible amphiphilic sperm-shaped heteroaromatic structure.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"434 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132079981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Postharvest losses from fungal pathogens to essential fruits and vegetables are enormous and alarming. Orthodox synthetic fungicides are being used as a regular practice to restrict these losses. However, now by knowing the hazards of these chemical-based fungicides, the situation demands alternative green technology. Consequently, many angiosperms plant extracts have been evaluated for their antifungal nature and achieved substantial success. However, the second most prevalent flora on land, i.e. bryophytes, have been scarcely used and somewhat remain neglected besides their remarkable thallus organization, water relations and antimicrobial potential. For postharvest fungus control, these bryophytes, the first land plants' extracts to be researched and promoted due to concerns about drug resistance, nephrotoxicity and biomagnification related to current synthetic fungicides. Since these amphibious plants have their unique protective mechanism against fungal or bacterial attacks due to their unique phytochemistry, therefore have great potential to be used as eco-friendly fungicides. Considering these factors, this article seeks to direct the attention of interested researchers toward the relatively accessible but vast underutilised bryo-diversity to investigate their remarkable potential as postharvest antifungal agents first in laboratories and then on a commercial scale in the future.
{"title":"Bryophytes as a safeguard of fruits from postharvest fungal diseases: A Review","authors":"S. Joshi, P. Bhardwaj, A. Alam","doi":"10.53365/nrfhh/145476","DOIUrl":"https://doi.org/10.53365/nrfhh/145476","url":null,"abstract":"Postharvest losses from fungal pathogens to essential fruits and vegetables are enormous and alarming. Orthodox synthetic fungicides are being used as a regular practice to restrict these losses. However, now by knowing the hazards of these chemical-based fungicides, the situation demands alternative green technology. Consequently, many angiosperms plant extracts have been evaluated for their antifungal nature and achieved substantial success. However, the second most prevalent flora on land, i.e. bryophytes, have been scarcely used and somewhat remain neglected besides their remarkable thallus organization, water relations and antimicrobial potential. For postharvest fungus control, these bryophytes, the first land plants' extracts to be researched and promoted due to concerns about drug resistance, nephrotoxicity and biomagnification related to current synthetic fungicides. Since these amphibious plants have their unique protective mechanism against fungal or bacterial attacks due to their unique phytochemistry, therefore have great potential to be used as eco-friendly fungicides. Considering these factors, this article seeks to direct the attention of interested researchers toward the relatively accessible but vast underutilised bryo-diversity to investigate their remarkable potential as postharvest antifungal agents first in laboratories and then on a commercial scale in the future.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132875378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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