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DETERMINATION OF CORNEAL POWER AFTER REFRACTIVE SURGERY WITH EXCIMER LASER: A CONCISE REVIEW. 准分子激光屈光手术后角膜功率的测定:简要回顾。
Q4 Medicine Pub Date : 2023-01-01
V Galvis, A Tello, V Otoya, S Arba-Mosquera, Villamizar, A Translateur, R Morales

Refractive surgery with excimer laser has been a very common surgical procedure worldwide during the last decades. Currently, patients who underwent refractive surgery years ago are older, with a growing number of them now needing cataract surgery. To establish the power of the intraocular lens to be implanted in these patients, it is essential to define the true corneal power. However, since the refractive surgery modified the anterior, but not the posterior surface of the cornea, the determination of the corneal power in this group of patients is challenging. This article reviews the different sources of error in finding the true corneal power in these cases, and comments on several approaches, including the clinical history method as described originally by Holladay, and a modified version of it, as well as new alternatives based on corneal tomography, using devices that are able to measure the actual anterior and posterior corneal curvatures, which have emerged in recent years to address this issue.

近几十年来,准分子激光屈光手术在世界范围内已成为一种非常普遍的手术方法。目前,几年前接受过屈光手术的患者年龄较大,现在需要白内障手术的患者越来越多。为了确定这些患者需要植入的人工晶状体的度数,有必要确定角膜的真实度数。然而,由于屈光手术改变的是角膜的前表面,而不是角膜的后表面,因此确定这组患者的角膜功率是具有挑战性的。本文回顾了在这些病例中发现真实角膜力量的不同误差来源,并对几种方法进行了评论,包括Holladay最初描述的临床病史方法及其修改版本,以及基于角膜断层扫描的新替代方法,使用能够测量实际角膜前和后曲率的设备,近年来出现了解决这一问题的方法。
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引用次数: 0
TRAUMA-RELATED ACUTE MACULAR NEURORETINOPATHY. A CASE REPORT. 创伤性急性黄斑神经视网膜病变。一份病例报告。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.31348/2023/16
H Hasani, S Sheikhghomi, M Ojani

Aims: To introduce a case report and review the literature on trauma-related acute macular neuroretinopathy as an unusual etiology of acute macular neuroretinopathy.

Material and methods: A 24-year-old man presented with unilateral paracentral scotoma following non-ocular trauma in a car accident. The relative afferent pupillary defect was negative and the best corrected visual acuities of both eyes were 10/10 (by the Snellen chart scale).

Results: Retinoscopy revealed a reduced foveal reflex, along with a small pre-retinal hemorrhage over the mid-pathway of the supranasal arteriole. OCT images showed an obvious ellipsoid zone (EZ) layer disruption in the macula of the left eye. The infrared fundus photograph of the same eye revealed a distinct hyporeflective area involving the macula. On fundus angiography, no macular vascular lesion was detected. The scotoma persisted after 3 months follow-up.

Conclusion: Non-ocular trauma including head or chest trauma without direct ocular injury accounts for most cases of trauma-related acute macular neuroretinopathy. It is important to distinguish this entity, given that there are also unremarkable findings in the retinal examination of these patients. Indeed, proper clinical suspicion leads to further suitable investigations and impedes other extraordinary images, which are the basic rules in the management of traumatic patients suffering multiple injuries and incurring medical expenses.

目的:介绍一例外伤相关性急性黄斑神经视网膜病变的病例报告,并回顾相关文献。材料和方法:一名24岁的男性在车祸中出现非眼外伤后单侧中央旁暗斑。瞳孔相对传入缺损阴性,双眼最佳矫正视力为10/10 (Snellen量表)。结果:视网膜镜检查显示中央凹反射减少,鼻上小动脉中间通路伴有少量视网膜前出血。OCT示左眼黄斑明显椭球区(EZ)层破裂。同一只眼睛的红外眼底照片显示一个明显的低反射区,包括黄斑。眼底血管造影未见黄斑血管病变。随访3个月后,暗斑仍然存在。结论:创伤性急性黄斑神经视网膜病变以头部或胸部外伤为主,无直接眼部损伤。考虑到在这些患者的视网膜检查中也有不显著的发现,区分这种实体是很重要的。事实上,适当的临床怀疑导致进一步的适当调查,并阻碍其他异常图像,这是管理多重受伤和产生医疗费用的创伤患者的基本规则。
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引用次数: 0
SEVERE NEAR REFLEX SPASM IN A HEALTHY TEENAGER. A CASE REPORT. 一个健康青少年的严重近反射性痉挛。一份病例报告。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.31348/2023/15
G Mejía, S Guevara, Y Salgado, A Tello
INTRODUCTION Spasm of the near reflex usually includes accommodative spasm, esophoria/tropia, and different degrees of miosis. Patients usually refer to distance blurred and fluctuating vision, ocular discomfort, and headaches. The diagnosis is established with refraction with and without cycloplegia; most of the cases have a functional etiology. However, some cases require neurological conditions to be ruled out; cycloplegics have an important diagnostic and therapeutic role. PURPOSE To describe a case of bilateral severe accommodative spasm in a healthy 14-year-old teenager. CASE PRESENTATION A 14-year-old boy with progressive diminished visual acuity attended for YSP consultation. The diagnosis of bilateral spasm of the near reflex was made, based on a gap refraction of 9.75 D between retinoscopy with and without cycloplegia and esophoria with normal keratometry and axial length. The spasm was eliminated with 2 drops of cycloplegic in each eye separated by 15 days; no clear etiology was found other than the start of school. CONCLUSION Clinicians should be aware of pseudomyopia, especially in children with acute changes in visual acuity, who are usually exposed to myopigenic environmental factors that induce overstimulation of the parasympathetic third cranial nerve's innervation.
简介:近反射痉挛通常包括调节性痉挛、食管/斜视和不同程度的瞳孔缩小。患者通常表现为距离模糊、视力波动、眼部不适和头痛。诊断是建立在有或没有单眼麻痹的屈光;大多数病例有功能性病因。然而,有些病例需要排除神经系统疾病;独眼麻痹症具有重要的诊断和治疗作用。目的:描述一例健康的14岁青少年双侧严重的适应性痉挛。病例介绍:一名14岁进行性视力下降的男孩参加YSP会诊。根据角膜度数和眼轴长度正常的食管与伴和不伴睫状体麻痹的视网膜镜之间的间隙屈光度为9.75 D,诊断双侧近反射痉挛。每眼2滴截瘫液,间隔15天消除痉挛;除开始上学外,未发现明确的病因。结论:临床医生应注意假性近视,特别是急性视力改变的儿童,他们通常暴露于致近视的环境因素中,导致副交感神经第三颅神经的神经支配过度刺激。
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引用次数: 0
CHANGE OF SURGICALLY INDUCED CORNEAL ASTIGMATISM AND POSITION OF ARTIFICIAL INTRAOCULAR LENS OVER TIME. 手术引起的角膜散光和人工晶状体位置随时间的变化。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.31348/2023/14
I Popov, J Juhas, K Kopálová, V Krásnik

Aims: To analyze changes in surgically induced corneal astigmatism and articial intraocular lens (IOL) stability over time following cataract surgery. To compare the interchangeability of measurements between an automatic keratorefractometer (AKRM) and a biometer.

Material and methods: In this prospective observational study, the above-mentioned parameters were collected from 25 eyes (25 subjects) on the first day, first week, first and third month after uncomplicated cataract surgery. We used IOL-induced astigmatism (difference between refractometry and keratometry) as an indirect indicator of IOL stability change. We used the Blant-Altman method to analyze consistency between devices.

Results: At the above time points, surgically induced astigmatism (SIA) decreased as follows: 0.65 D; 0.62 D; 0.60 D and 0.41 D (in the first day, week, month and third month respectively). Astigmatism induced by changes of the position of the IOL varied as follows: 0.88 D; 0.59 D; 0.44 D and 0.49 D. Changes in both parameters were statistically significant (p0.05).

Conclusion: Both surgically induced astigmatism and astigmatism induced by IOL decreased over time, in which both changes were statistically significant. The decrease in SIA was most pronounced between the first and third month after surgery. For IOL-induced astigmatism, the greatest decrease was within the first month after surgery. The differences in measurement between the biometer and AKRM were statistically insignificant, but the clinical interchangeability between the given methods is questionable, especially with regard to measurement of the astigmatism angle.

目的:分析白内障手术后角膜散光和人工晶状体稳定性随时间的变化。比较自动角折计(AKRM)和生物计测量值的互换性。材料与方法:本前瞻性观察研究在白内障术后第一天、第一周、第1个月和第3个月采集25只眼(25名受试者)的上述参数。我们使用人工晶状体诱导的散光(屈光和角膜屈光的差异)作为人工晶状体稳定性变化的间接指标。我们使用Blant-Altman方法来分析设备之间的一致性。结果:在上述时间点,手术性散光(SIA)降低幅度如下:0.65 D;0.62 D;0.60 D、0.41 D(第1天、第1周、第1月、第3月)。人工晶状体位置变化引起的散光变化如下:0.88 D;0.59 D;0.44 D、0.49 D,两项参数变化均有统计学意义(p0.05)。结论:手术散光和人工晶状体散光均随时间的推移而降低,两者变化均有统计学意义。术后第一个月至第三个月,SIA的下降最为明显。对于人工晶状体引起的散光,术后第一个月内下降幅度最大。生物计和AKRM测量的差异在统计学上不显著,但给定方法之间的临床互换性值得怀疑,特别是在散光角的测量方面。
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引用次数: 0
CHANGES IN THE VISION OF ADULT AMBLYOPIC PATIENTS FOLLOWING CLEAR LENS EXTRACTION. 成人弱视患者摘除透明晶状体后视力的变化。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.31348/2023/17
J Halička, R Vida, M Gajdoš, M Králik, M Javorka, L Jančo, P Žiak

Aims: The aim of the study was to retrospectively evaluate changes in vision after the implantation of trifocal (tIOL) or rotationally asymmetric multifocal artificial intraocular lenses (mIOL) in patients undergoing clear lens extraction. The main goal was to determine whether changes to central visual acuity occur after the implantation of an IOL at a follow-up examination after one year. Other objectives were to determine the difference between the groups with implanted diffractive and rotationally asymmetric artificial intraocular lenses, as well as to evaluate the risk of accurate correction in patients who had lived most of their lives "undercorrected".

Material and methods: In our study, we present a retrospective longitudinal evaluation of results in patients after the implantation of an artificial intraocular lens. In the period from 2013 to 2020, we evaluated changes in the vision of 22 patients aged 39-59 years, of whom 18 were women and 5 were men. The average preoperative refraction of myopic eyes was +5.7 ±2.13 Dsf and +1.24 ±0.86 Dcyl. In amblyopic eyes, 7 diffractive lenses and 15 rotationally asymmetric lenses were used.

Results: Uncorrected distance visual acuity before surgery and one year (1Y) after was 0.13 ±0.09 vs. 0.57 ±0.28 (p < 0.001); the best corrected distance visual acuity before and 1Y after was 0.53 ±0.22 vs. 0.62 ±0.29 (p = 0.024); uncorrected near visual acuity before and 1Y after was 0.06 ±0.06 vs. 0.48 ±0.32 (p < 0.001); the best corrected near visual acuity before and afér the surgical procedure was 0.45 ±0.27vs. 0.55 ±0.35 (p = 0.014).

Conclusion: Implantation of tIOL and mIOL lenses was effective in our group of patients with amblyopia, thus improving uncorrected distance and near visual acuity and without serious adverse effects. At the same time, we evaluate that the change in refraction and the removal of anisometropia lead to a significant change in the best corrected visual acuity for distance or near vision at the one-year follow-up examination.

目的:本研究的目的是回顾性评价接受透明晶状体摘出术的患者在植入三焦(tIOL)或旋转不对称多焦人工晶状体(mIOL)后视力的变化。主要目的是在一年后的随访检查中确定人工晶状体植入后中央视力是否发生变化。其他目的是确定植入衍射和旋转不对称人工晶状体组之间的差异,以及评估那些大部分时间都处于“未矫正”状态的患者进行准确矫正的风险。材料和方法:在我们的研究中,我们对人工晶状体植入术后的患者进行了回顾性的纵向评价。在2013年至2020年期间,我们评估了22名年龄在39-59岁之间的患者的视力变化,其中18名女性,5名男性。术前近视眼平均屈光度分别为+5.7±2.13 Dsf和+1.24±0.86 Dcyl。弱视采用衍射晶状体7枚,旋转非对称晶状体15枚。结果:术前和术后1年(1Y)未矫正距离视力分别为0.13±0.09和0.57±0.28 (p <0.001);治疗前和治疗后1Y的最佳矫正距离视力分别为0.53±0.22和0.62±0.29 (p = 0.024);术前、术后1Y未矫正近视力分别为0.06±0.06∶0.48±0.32 (p <0.001);手术前后最佳矫正近视力为0.45±0.27。0.55±0.35 (p = 0.014)。结论:本组弱视患者行tIOL和mIOL晶状体植入术,可改善未矫正的远近视力,无严重不良反应。同时,在一年的随访检查中,我们评估了屈光的改变和屈光参差的去除导致远处或近处最佳矫正视力的显著变化。
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引用次数: 0
THE PREVALENCE OF MYOPIA IN SCHOOL-AGE CHILDREN IN SLOVAKIA AND THE COVID-19 PANDEMIC. 斯洛伐克学龄儿童近视患病率与COVID-19大流行
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.31348/2023/24
L Pršová, J Halička, M Kozár, Z Kuderavá, M Pršo, Ľ Jakušová, P Bánovčin, P Žiak

Aims: The aim of the authors' study was to determine the prevalence of myopia and premyopia in children and adolescents attending primary school in a village in the north of Slovakia in the period before and after the peak of the Covid-19 pandemic.

Material and methods: Changes in the spherical equivalent and axial length of the eyes were measured in 2019 and 2022 in a group of 47 children and adolescents within the age range of 7-12 years at the time of first measurement. In all the individuals, refraction was measured using an automatic keratorefractometer without the use of cycloplegic eye drops, and axial length was measured with an optical biometer. Refraction was also measured using an automatic keratorefractometer after using cycloplegic eye drops.

Results: We recorded a significant change in the mean spherical equivalent (1.02 ±1.16 D vs. 0.72 ±1.29) and the axial length of the eyes (23.05 ±0.72mm vs. 23.30 ±0.74mm) when comparing the measurements from 2019 to 2022. The probands manifested a myopic refractive shift of -0.30 D throughout the entire cohort (-0.24 D in boys and -0.38 D in girls), and the mean axial length increased by 0.2 mm in the entire cohort (by 0.3 mm in boys and 0.2 mm in girls). The percentage of myopic and premyopic eyes increased (4.3% vs. 8.5% a 31.9% vs. 48.9%).

Conclusion: We noted a decrease in the spherical equivalent and increase in the axial length of the eyes after the Covid-19 pandemic compared to the period before the pandemic in Slovak school-aged children. During this period, the prevalence of myopia and premyopia increased.

目的:作者研究的目的是确定斯洛伐克北部一个村庄小学儿童和青少年在Covid-19大流行高峰期前后的近视和准近视患病率。材料与方法:于2019年和2022年对47名年龄在7-12岁的儿童和青少年进行首次测量时的眼球当量和眼轴长度的变化。在所有个体中,使用自动角膜屈光计测量屈光,不使用眼药水,并使用光学生物计测量眼轴长度。使用眼药水后,也用自动角膜屈光计测量屈光。结果:与2019年和2022年相比,我们记录了平均球当量(1.02±1.16 D vs 0.72±1.29)和眼轴长度(23.05±0.72mm vs 23.30±0.74mm)的显著变化。在整个队列中,先证者的近视屈光位移为-0.30 D(男孩为-0.24 D,女孩为-0.38 D),整个队列的平均眼轴长度增加0.2 mm(男孩为0.3 mm,女孩为0.2 mm)。近视眼和准近视眼的比例增加(4.3%对8.5%,31.9%对48.9%)。结论:我们注意到,与新冠肺炎大流行前相比,斯洛伐克学龄儿童在新冠肺炎大流行后眼睛的球形当量减少,眼轴长度增加。在此期间,近视和准近视的患病率增加。
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引用次数: 0
DETERMINATION OF CORNEAL POWER AFTER REFRACTIVE SURGERY WITH EXCIMER LASER: A CONCISE REVIEW. 准分子激光屈光手术后角膜功率的测定:简要回顾。
Q4 Medicine Pub Date : 2023-01-01
V Galvis, A Tello, V Otoya, S Arba-Mosquera, Villamizar, A Translateur, R Morales

Refractive surgery with excimer laser has been a very common surgical procedure worldwide during the last decades. Currently, patients who underwent refractive surgery years ago are older, with a growing number of them now needing cataract surgery. To establish the power of the intraocular lens to be implanted in these patients, it is essential to define the true corneal power. However, since the refractive surgery modified the anterior, but not the posterior surface of the cornea, the determination of the corneal power in this group of patients is challenging. This article reviews the different sources of error in finding the true corneal power in these cases, and comments on several approaches, including the clinical history method as described originally by Holladay, and a modified version of it, as well as new alternatives based on corneal tomography, using devices that are able to measure the actual anterior and posterior corneal curvatures, which have emerged in recent years to address this issue.

近几十年来,准分子激光屈光手术在世界范围内已成为一种非常普遍的手术方法。目前,几年前接受过屈光手术的患者年龄较大,现在需要白内障手术的患者越来越多。为了确定这些患者需要植入的人工晶状体的度数,有必要确定角膜的真实度数。然而,由于屈光手术改变的是角膜的前表面,而不是角膜的后表面,因此确定这组患者的角膜功率是具有挑战性的。本文回顾了在这些病例中发现真实角膜力量的不同误差来源,并对几种方法进行了评论,包括Holladay最初描述的临床病史方法及其修改版本,以及基于角膜断层扫描的新替代方法,使用能够测量实际角膜前和后曲率的设备,近年来出现了解决这一问题的方法。
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引用次数: 0
PATHOGENESIS AND CURRENT METHODS OF TREATMENT OF SECONDARY UVEITIC GLAUCOMA. A REVIEW. 继发性葡萄膜炎性青光眼的发病机制和现有治疗方法。综述。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.31348/2023/7
E Škrlová, P Svozílková, J Heissigerová, M Fichtl

Secondary uveitic glaucoma is a serious sight-threatening complication of intraocular inflammation (uveitis). It develops in approximately 10-20% of patients with uveitis (although this figure may be higher depending on the type of inflammation). It is more commonly associated with chronic forms of uveitis, especially anterior uveitis. Elevation of intraocular pressure (IOP) and the development of secondary glaucoma arise as a direct or indirect consequence of uveitis, and may develop further in association with therapy for intraocular inflammation. Several types of uveitic glaucoma are distinguished according to the mechanism of development: open-angle secondary glaucoma (including steroid-induced secondary glaucoma), angle-closure secondary glaucoma, and a combination of both. It is necessary to determine the pathogenesis of uveitis and target the treatment of the inflammatory process according to it. Subsequently, it is necessary to determine the type of secondary glaucoma, which influences the choice of therapy. Compensation for IOP should be achieved as quickly as possible, before irreversible damage to the optic nerve and visual field occurs. In the first instance, we choose conservative pharmacological therapy. However, this therapy fails more often in secondary uveitic glaucoma than in primary open-angle glaucoma. For this reason, surgical or laser therapy is necessary for refractory glaucoma. Trabeculectomy remains the gold standard in surgical therapy for secondary uveitic glaucoma, but other surgical techniques can also be used (Ahmed drainage implants, goniotomy in the paediatric population, surgical iridectomy, and synechiae for angle closure etc.). The choice of method is individualised according to the clinical findings of the patient and previous ocular procedures. However, the main factor influencing the success and efficacy of filtration surgery is adequate therapy and control of the intraocular inflammatory process.

继发性葡萄膜炎性青光眼是眼内炎症(葡萄膜炎)的一种严重威胁视力的并发症。约有 10-20% 的葡萄膜炎患者会患上这种疾病(但根据炎症的类型,这一数字可能会更高)。它更常见于慢性葡萄膜炎,尤其是前葡萄膜炎。眼内压(IOP)升高和继发性青光眼的发生是葡萄膜炎的直接或间接后果,并可能与眼内炎症治疗相关联而进一步发展。葡萄膜炎性青光眼根据发病机制可分为几种类型:开角型继发性青光眼(包括类固醇诱发的继发性青光眼)、闭角型继发性青光眼以及两者的结合。有必要确定葡萄膜炎的发病机制,并根据发病机制有针对性地治疗炎症过程。随后,有必要确定继发性青光眼的类型,这将影响治疗方法的选择。应在对视神经和视野造成不可逆转的损害之前,尽快实现对眼压的补偿。首先,我们会选择保守的药物治疗。然而,与原发性开角型青光眼相比,这种疗法在继发性葡萄膜炎性青光眼中更容易失败。因此,难治性青光眼必须采用手术或激光治疗。小梁切除术仍是继发性葡萄膜炎性青光眼手术治疗的金标准,但也可采用其他手术技术(艾哈迈德引流植入术、儿童眼球切开术、手术虹膜切除术、闭角缝合术等)。手术方法的选择要根据患者的临床表现和以往的眼部手术情况而定。不过,影响滤过手术成功和疗效的主要因素是适当的治疗和对眼内炎症过程的控制。
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引用次数: 0
RARE NON-SURGICAL RELATED MASSIVE SPONTANEOUS SUPRACHOROIDAL HEMORRHAGE. A CASE REPORT. 罕见的非手术相关性自发性脉络膜上大出血。一份病例报告。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.31348/2023/26
Hasan, M Musa, Ali, M Mustapha, Halim

Aims: We present two rare cases of non-surgical-related massive spontaneous suprachoroidal hemorrhage.

Case report: The first case was a 73-year-old male with uncontrolled hypertension, who presented with left vision loss, only able to perceive light, with very high intraocular pressure (IOP) and blood pressure (BP), 68 mmHg and 196/106 mmHg, respectively. Ocular examination showed a limited fundus view, and the B-scan revealed near kissing suprachoroidal hemorrhage. The second case was a 59-year-old male, post valve replacement surgery on life-long warfarin, who presented with hand movement vision and IOP of 47 mmHg. The B-scan showed massive submacular and suprachoroidal hemorrhage with therapeutic range International Normalized Ratio (INR).

Conclusion: Suprachoroidal hemorrhage is one of the rare complications that can be seen in any ocular surgery. However, spontaneous suprachoroidal hemorrhage is a rarer disease. Most of the reported cases are associated with underlying medical conditions. Thus prevention is crucial. This involves ophthalmologists, physicians and general practitioners in managing this group of patients with associated risk factors, for better recognition of this devastating ocular complication in which early detection may reduce ocular morbidity.

目的:我们报告两例罕见的非手术相关自发性脉络膜上出血。病例报告:首例患者为73岁男性,高血压未得到控制,表现为左视力丧失,仅能感知光,眼压(IOP)和血压(BP)非常高,分别为68 mmHg和196/106 mmHg。眼部检查显示眼底视野受限,b超显示近吻处脉络膜上出血。第二例患者为59岁男性,接受终身华法林瓣膜置换术后,出现手部运动视力和IOP为47 mmHg。b超显示黄斑下及脉络膜上大量出血,治疗范围为国际标准化比值(INR)。结论:脉络膜上出血是眼科手术中罕见的并发症之一。然而,自发性脉络膜上出血是一种罕见的疾病。大多数报告的病例都与潜在的医疗条件有关。因此,预防至关重要。这需要眼科医生、内科医生和全科医生来管理这组有相关危险因素的患者,以便更好地识别这种破坏性的眼部并发症,早期发现可能会降低眼部发病率。
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引用次数: 0
GIANT PROLACTINOMA. A CASE REPORT. 巨泌乳素瘤。一份病例报告。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.31348/2023/20
Z Šulavíková, V Krásnik

Aim: Prolactinoma is a pituitary adenoma that secretes prolactin. Approximately 40% of all pituitary adenomas are prolactinomas. According to size, they are divided into micro, macro and giant prolactinomas. In women, prolactinomas cause irregularities of the menstrual cycle such as amenorrhea, galactorrhea, weight gain, in both sexes they cause sterility, hypogonadism, decreased libido and depression. In macroadenomas, symptoms due to the compression of the surrounding structures are also manifested, such as headache, vomiting, lower chiasmatic syndrome and ophthalmoplegia. Loss of the visual field due to compression of the optic chiasm is caused by a tumor larger than 10-15 mm with suprasellar spreading, which breaks through the diaphragma sellae. Giant prolactinomas are larger than 40 mm and make up 1-5% of all prolactinomas.

Case report: In this article I present the case of a 38-year-old woman from Ukraine with advanced chiasmatic syndrome caused by a giant prolactinoma. The tumor is infiltrating the left cavernous sinus, causing left-sided amaurosis and right-sided temporal hemianopsia.

Conclusion: Inferior chiasmatic syndrome is characterized by bitemporal hemianopsia, a deterioration of visual acuity, bilateral bow-tie descendent atrophy of the optic nerve disc, and hemianopic rigidity of the pupils. Macroprolactinomas occur more frequently in men than in women. The diagnosis is often delayed, probably because the symptoms of hyperprolactinemia are less obvious in men, while women tend to present earlier due to menstrual cycle irregularities. Prolactinomas usually have a good prognosis. Effective medical treatment with dopamine agonists is available. Knowledge of the prolactinoma symptoms could help the diagnosis of compressive lesions of the optic chiasm.

目的:催乳素瘤是一种分泌催乳素的垂体腺瘤。约40%的垂体腺瘤为泌乳素瘤。按大小分为微泌乳素瘤、宏泌乳素瘤和巨泌乳素瘤。在女性中,催乳素瘤引起月经周期不规律,如闭经、溢乳、体重增加,在两性中都引起不育、性腺功能减退、性欲下降和抑郁。在大腺瘤中,由于周围结构受到压迫,也表现出头痛、呕吐、下交叉综合征和眼麻痹等症状。视交叉压迫导致视野丧失是由大于10- 15mm的肿瘤引起的,其鞍上扩散,突破鞍膈。巨大催乳素瘤大于40毫米,占所有催乳素瘤的1-5%。病例报告:在这篇文章中,我提出的情况下,38岁的妇女从乌克兰与晚期交叉综合征引起的巨大催乳素瘤。肿瘤浸润左侧海绵窦,造成左侧黑朦及右侧颞部偏盲。结论:下交叉综合征以双颞偏视、视力下降、双侧视神经盘弓结性萎缩、瞳孔偏视强直为特征。巨泌乳素瘤在男性中比在女性中更常见。诊断往往被推迟,可能是因为高泌乳素血症的症状在男性中不太明显,而女性往往由于月经周期不规律而更早出现。催乳素瘤通常预后良好。使用多巴胺激动剂进行有效的医学治疗是可行的。了解催乳素瘤的症状有助于诊断视交叉的压缩性病变。
{"title":"GIANT PROLACTINOMA. A CASE REPORT.","authors":"Z Šulavíková,&nbsp;V Krásnik","doi":"10.31348/2023/20","DOIUrl":"https://doi.org/10.31348/2023/20","url":null,"abstract":"<p><strong>Aim: </strong>Prolactinoma is a pituitary adenoma that secretes prolactin. Approximately 40% of all pituitary adenomas are prolactinomas. According to size, they are divided into micro, macro and giant prolactinomas. In women, prolactinomas cause irregularities of the menstrual cycle such as amenorrhea, galactorrhea, weight gain, in both sexes they cause sterility, hypogonadism, decreased libido and depression. In macroadenomas, symptoms due to the compression of the surrounding structures are also manifested, such as headache, vomiting, lower chiasmatic syndrome and ophthalmoplegia. Loss of the visual field due to compression of the optic chiasm is caused by a tumor larger than 10-15 mm with suprasellar spreading, which breaks through the diaphragma sellae. Giant prolactinomas are larger than 40 mm and make up 1-5% of all prolactinomas.</p><p><strong>Case report: </strong>In this article I present the case of a 38-year-old woman from Ukraine with advanced chiasmatic syndrome caused by a giant prolactinoma. The tumor is infiltrating the left cavernous sinus, causing left-sided amaurosis and right-sided temporal hemianopsia.</p><p><strong>Conclusion: </strong>Inferior chiasmatic syndrome is characterized by bitemporal hemianopsia, a deterioration of visual acuity, bilateral bow-tie descendent atrophy of the optic nerve disc, and hemianopic rigidity of the pupils. Macroprolactinomas occur more frequently in men than in women. The diagnosis is often delayed, probably because the symptoms of hyperprolactinemia are less obvious in men, while women tend to present earlier due to menstrual cycle irregularities. Prolactinomas usually have a good prognosis. Effective medical treatment with dopamine agonists is available. Knowledge of the prolactinoma symptoms could help the diagnosis of compressive lesions of the optic chiasm.</p>","PeriodicalId":39839,"journal":{"name":"Ceska a Slovenska Oftalmologie","volume":"79 3","pages":"143-148"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10032661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Ceska a Slovenska Oftalmologie
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