Introduction: Coronavirus Disease 2019 (COVID-19) is a pandemic infectious disease caused by SARS-CoV-2 that was declared in March 2020. The goal of this study was to see if there was a link between patient characteristics (age, gender) and patient severity with the use of Covid-19 antiviral drugs in Covid-19 patients hospitalized at Rumah Sakit Ichsan Medical Center Bintaro between July and December 2021. Methods: Through retrospective data tracing, this study employed an analytical observational method with a cross sectional design. The research data was gathered from Covid-19’s medical records. With purposive sampling, the number of respondents as a sample reached 107 patients. Results: The results showed that the age range of most Covid-19 patients was 26–45 years old by 46.7%, males were more exposed to Covid-19 by 52.3%, the highest degree of severity was included in the mild category, namely 62.6%, and the highest use of antiviral was favipiravir at 70.1%. The analysis revealed that there was no significant relationship between age (p value = 0.346) and gender (p value = 0.387) with the use of Covid-19 antiviral drugs, but there was a significant relationship between patient everity and antiviral drug use (p value = 0.005). Conclusion: Finally, there is no significant relationship between age and gender with the use of Covid-19 antiviral drugs, while between the severity of patients there is a significant relationship with the use of Covid-19 antiviral drugs.
简介:2019冠状病毒病(COVID-19)是由SARS-CoV-2引起的大流行性传染病，于2020年3月宣布。本研究的目的是了解2021年7月至12月期间在宾塔罗Rumah Sakit Ichsan医疗中心住院的Covid-19患者中，患者特征(年龄、性别)和患者严重程度与使用Covid-19抗病毒药物之间是否存在联系。方法:通过回顾性资料追溯，采用横断面设计的分析观察方法。研究数据是从Covid-19的医疗记录中收集的。有目的的抽样，作为样本的回答者达到107例。结果:结果显示，26-45岁感染者最多，占46.7%，男性感染者较多，占52.3%，严重程度最高的为轻度，占62.6%，抗病毒药物使用率最高的为favipiravir，占70.1%。分析发现，年龄(p值= 0.346)和性别(p值= 0.387)与抗病毒药物的使用无显著相关，但患者的年龄与抗病毒药物的使用有显著相关(p值= 0.005)。结论:最后，年龄和性别与Covid-19抗病毒药物的使用无显著相关性，而患者严重程度与Covid-19抗病毒药物的使用有显著相关性。
{"title":"Relationship Between Patient Characteristics and Severity With the Use of Antiviral Drugs Among Covid-19 Patients at Rumah Sakit Ichsan Medical Centre Bintaro","authors":"Gina Aulia, Humaira Fadhilah, Tania Rizki Amalia, Fenita Purnama Sari Indah, Nurihardianti Nurihardianti, Sintia Sintia, Sandeep Poddar","doi":"10.47836/mjmhs.19.s9.18","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.18","url":null,"abstract":"Introduction: Coronavirus Disease 2019 (COVID-19) is a pandemic infectious disease caused by SARS-CoV-2 that was declared in March 2020. The goal of this study was to see if there was a link between patient characteristics (age, gender) and patient severity with the use of Covid-19 antiviral drugs in Covid-19 patients hospitalized at Rumah Sakit Ichsan Medical Center Bintaro between July and December 2021. Methods: Through retrospective data tracing, this study employed an analytical observational method with a cross sectional design. The research data was gathered from Covid-19’s medical records. With purposive sampling, the number of respondents as a sample reached 107 patients. Results: The results showed that the age range of most Covid-19 patients was 26–45 years old by 46.7%, males were more exposed to Covid-19 by 52.3%, the highest degree of severity was included in the mild category, namely 62.6%, and the highest use of antiviral was favipiravir at 70.1%. The analysis revealed that there was no significant relationship between age (p value = 0.346) and gender (p value = 0.387) with the use of Covid-19 antiviral drugs, but there was a significant relationship between patient everity and antiviral drug use (p value = 0.005). Conclusion: Finally, there is no significant relationship between age and gender with the use of Covid-19 antiviral drugs, while between the severity of patients there is a significant relationship with the use of Covid-19 antiviral drugs.","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tatik Pujiastuti, Musheer A. Aljaberi, Tukimin Sansuwito, Bibi Florina Abdullah, Ruma Poddar
Introduction: Hypertension is a cardiovascular disease that evolves worldwide. Hypertension prevalence increased by 7.61% over five years, from 26,5% in 2013 to 34,11% in 2018 in Indonesia. Then in Yogyakarta, the prevalence of hypertension is 8.8% higher than the national average. It has become the leading cause of non-communicable diseases. The problem has focused on the issue of hypertension management and has not been effective. According to various sources, hypertension self-care education via smartphone applications is one of the interventions used to improve self-care behaviour in hypertensive patients. Thus, it is important to study the effectiveness of these interventions on hypertensive patients. The study aimed to determine the effectiveness of android-based hypertension self-care education on knowledge and behavior among hypertensive patients. Methods: A quantitative descriptive-analytic study was conducted. One hundred and eight hypertensive patients were selected in Yogyakarta randomly. The patients followed an android-based hypertension self-care education programme for three months. Results: Statistical analysis with paired and independent t-tests showed a significant difference in self-care knowledge and behavior before and after intervention in the intervention group (p=0.000 <0.05; p=0.000<0.05, respectively). There was a significant difference in self-care knowledge and behavior between the intervention group and the control group (p=0.000<0.05; p=0.003<0.05, respectively). Conclusion: A minimal, three-month android-based hypertension self-care education programme enhanced self-care knowledge and behavior among hypertensive patients. It was suggested that the nurses educate hypertensive patients about hypertensionself-care more intensively.
{"title":"Effectiveness of Self Care Education on Knowledge and Behavior Among Android-based Hypertension Patients at Yogyakarta Health Center","authors":"Tatik Pujiastuti, Musheer A. Aljaberi, Tukimin Sansuwito, Bibi Florina Abdullah, Ruma Poddar","doi":"10.47836/mjmhs.19.s9.1","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.1","url":null,"abstract":"Introduction: Hypertension is a cardiovascular disease that evolves worldwide. Hypertension prevalence increased by 7.61% over five years, from 26,5% in 2013 to 34,11% in 2018 in Indonesia. Then in Yogyakarta, the prevalence of hypertension is 8.8% higher than the national average. It has become the leading cause of non-communicable diseases. The problem has focused on the issue of hypertension management and has not been effective. According to various sources, hypertension self-care education via smartphone applications is one of the interventions used to improve self-care behaviour in hypertensive patients. Thus, it is important to study the effectiveness of these interventions on hypertensive patients. The study aimed to determine the effectiveness of android-based hypertension self-care education on knowledge and behavior among hypertensive patients. Methods: A quantitative descriptive-analytic study was conducted. One hundred and eight hypertensive patients were selected in Yogyakarta randomly. The patients followed an android-based hypertension self-care education programme for three months. Results: Statistical analysis with paired and independent t-tests showed a significant difference in self-care knowledge and behavior before and after intervention in the intervention group (p=0.000 <0.05; p=0.000<0.05, respectively). There was a significant difference in self-care knowledge and behavior between the intervention group and the control group (p=0.000<0.05; p=0.003<0.05, respectively). Conclusion: A minimal, three-month android-based hypertension self-care education programme enhanced self-care knowledge and behavior among hypertensive patients. It was suggested that the nurses educate hypertensive patients about hypertensionself-care more intensively.","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The global challenge in managing diabetes is the low level of patient health literacy. Health professionals have promoted the use of technology as an effort to improve patient health literacy. However, the data shows health literacy of urban area patients is higher than in rural areas. Also, many studies have focused on health literacy by using a quantitative approach and few studies have explored this issue more deeply to understand a patient’s real story about health literacy after they use the diabetes application. Method: We conducted a qualitative approach by using in-depth interviews to assess ten patients’ health literacy from one of the rural areas in Indonesia, before and after using the diabetes application. Results: The results showed that there was a change in the patients’ habit to take care of themselves more independently through the diabetes application compared to when they were more dependent on their families before they utilized the diabetes application. Conclusion: This study proved that health literacy could improve by using the diabetes application for patients in rural areas.
{"title":"Improving Diabetes Condition Through Health Literacy: A Case Study From Cianjur, West Java, Indonesia","authors":"Siti Kamillah Siti Kamillah, Santhna Letchmi Panduragan, Sandeep Poddar, Amiya Bhaumik","doi":"10.47836/mjmhs.19.s9.31","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.31","url":null,"abstract":"Introduction: The global challenge in managing diabetes is the low level of patient health literacy. Health professionals have promoted the use of technology as an effort to improve patient health literacy. However, the data shows health literacy of urban area patients is higher than in rural areas. Also, many studies have focused on health literacy by using a quantitative approach and few studies have explored this issue more deeply to understand a patient’s real story about health literacy after they use the diabetes application. Method: We conducted a qualitative approach by using in-depth interviews to assess ten patients’ health literacy from one of the rural areas in Indonesia, before and after using the diabetes application. Results: The results showed that there was a change in the patients’ habit to take care of themselves more independently through the diabetes application compared to when they were more dependent on their families before they utilized the diabetes application. Conclusion: This study proved that health literacy could improve by using the diabetes application for patients in rural areas.","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui Yi Koh, Nor Farahani Ali Othman, Ainihayati Abdul Rahim, Seri Intan Mokhtar, Khomaizon Abdul Kadir Pahirulzaman
Introduction: Flooding may cause the microbial population in the soil to move from one area to another. Actinomycete, a type of soil microbe, has the most commercial value due to its ability to produce secondary metabolites. This study aimed to elucidate the antimicrobial activities of actinomycetes isolated from flooded and unflooded areas. Methods: Soils samples were collected from flooded areas in Dabong, Kelantan, and unflooded areas in Jeli, Kelantan. Three isolation methods were used to isolate actinomycetes; Sonication, Centrifugation and Chloramine T. The isolated strains were screened for morphological characteristics based on their growth pattern (spore formation), colony color, aerial and substrate mycelia color, and soluble pigment formation in the growth medium. Morphologically different strains were tested against Escherichia coli and Candida albicans for its antibacterial and antifungal activities. Results: A total of 970 actinomycete strains were isolated from soil samples (570 strains from flooded soil and 400 strains from unflooded soils). Only 281 strains were morphologically different. Thirty actinomycete strains were tested for antibacterial and antifungal activity. Seventeen of these inhibit at least one test microorganism. Conclusion: In conclusion, our observations reveal that the soil samples obtained from flooded areas display a wide variety of actinomycetes, as evident from their morphological characteristics. This finding suggests that the flooded soil areas possess a higher diversity of actinomycetes compared to non-flooded soil areas. Furthermore, we found that 57% of the tested actinomycete strains exhibited activity against at least one test organism, indicating their potential for future research.
{"title":"Antimicrobial Activities of Actinomycetes Isolated From Flooded and Unflooded Soils","authors":"Hui Yi Koh, Nor Farahani Ali Othman, Ainihayati Abdul Rahim, Seri Intan Mokhtar, Khomaizon Abdul Kadir Pahirulzaman","doi":"10.47836/mjmhs.19.s9.7","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.7","url":null,"abstract":"Introduction: Flooding may cause the microbial population in the soil to move from one area to another. Actinomycete, a type of soil microbe, has the most commercial value due to its ability to produce secondary metabolites. This study aimed to elucidate the antimicrobial activities of actinomycetes isolated from flooded and unflooded areas. Methods: Soils samples were collected from flooded areas in Dabong, Kelantan, and unflooded areas in Jeli, Kelantan. Three isolation methods were used to isolate actinomycetes; Sonication, Centrifugation and Chloramine T. The isolated strains were screened for morphological characteristics based on their growth pattern (spore formation), colony color, aerial and substrate mycelia color, and soluble pigment formation in the growth medium. Morphologically different strains were tested against Escherichia coli and Candida albicans for its antibacterial and antifungal activities. Results: A total of 970 actinomycete strains were isolated from soil samples (570 strains from flooded soil and 400 strains from unflooded soils). Only 281 strains were morphologically different. Thirty actinomycete strains were tested for antibacterial and antifungal activity. Seventeen of these inhibit at least one test microorganism. Conclusion: In conclusion, our observations reveal that the soil samples obtained from flooded areas display a wide variety of actinomycetes, as evident from their morphological characteristics. This finding suggests that the flooded soil areas possess a higher diversity of actinomycetes compared to non-flooded soil areas. Furthermore, we found that 57% of the tested actinomycete strains exhibited activity against at least one test organism, indicating their potential for future research.","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nurul Nur Fazzana Dazrulhafizi, Elysha Nur Ismail, Reezal Ishak
Developing wound dressings with good properties to accelerate wound healing has always been challenging. Mammal collagen is well known as the desired choice among naturally produced dressings despite experiencing major drawbacks. Therefore, researchers have explored the by products of Oreochromis niloticus fish or red Nile tilapia, such as the scales and skin as alternative source of collagen. This narrative review analyzes the effectiveness of collagen extracted from Oreochromis niloticus skin and its beneficial properties to accelerate wound healing in vivo. Recent studies were compiled to provide a compact review on the effectiveness of the collagen in hastening wound healing process. Faster wound closure with upregulation of multiple growth factors, and high hydroxyproline content are some of the findings. The collagen extract could also promote the formation of epidermal layers, fibroblasts proliferation, and dermal reconstitution. Thus, Oreochromis niloticus skin collagen extract has the potential to be developed as an effective wound dressing.
{"title":"Effectiveness of Collagen Extracted From the Skin of Nile Tilapia Fish (Oreochromis niloticus) to Accelerate Wound Healing in vivo: A Narrative Review","authors":"Nurul Nur Fazzana Dazrulhafizi, Elysha Nur Ismail, Reezal Ishak","doi":"10.47836/mjmhs.19.s9.44","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.44","url":null,"abstract":"Developing wound dressings with good properties to accelerate wound healing has always been challenging. Mammal collagen is well known as the desired choice among naturally produced dressings despite experiencing major drawbacks. Therefore, researchers have explored the by products of Oreochromis niloticus fish or red Nile tilapia, such as the scales and skin as alternative source of collagen. This narrative review analyzes the effectiveness of collagen extracted from Oreochromis niloticus skin and its beneficial properties to accelerate wound healing in vivo. Recent studies were compiled to provide a compact review on the effectiveness of the collagen in hastening wound healing process. Faster wound closure with upregulation of multiple growth factors, and high hydroxyproline content are some of the findings. The collagen extract could also promote the formation of epidermal layers, fibroblasts proliferation, and dermal reconstitution. Thus, Oreochromis niloticus skin collagen extract has the potential to be developed as an effective wound dressing.","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fazliana Mansor, Liyana Ahmad Zamri, Hanifullah Khan
Introduction: Polycystic ovary syndrome (PCOS) is a common hormonal disorder worldwide among women of reproductive age. It is characterized by endocrine, reproductive, and metabolic abnormalities. Insulin resistance (IR) is one of its most important clinical features, which has been associated with metabolic disorders and increased risk of type 2 diabetes (T2D). This study aimed to explore the whole blood gene expression profiling related to IR in PCOS patients compared to controls. Methods: Blood RNA was extracted from 5 PCOS and 5 non-PCOS women with matched age and BMI. Homeostasis model assessment (HOMA-IR) was used to estimate the IR. The expression of IR genes was analyzed by Profiler PCR array. Results: Both groups have similar levels of HOMA-IR (p>0.05). However, differential expression levels were observed between them. Fourteen genes were upregulated and 26 genes were downregulated in PCOS samples. Among the upregulated genes (>2 fold-change, p-value<0.05) are ADIPOQ, ADIPOR1, OLR, IGF-1, and APOE. Downregulated genes (>-2 fold-change, p-value<0.05) include HK-2, IRS1, and SERPINE1. These genes are involved in insulin and adipokines signaling, commonly dysregulated in T2D. They are also involved in innate immunity and inflammatory processes and are important for lipid and carbohydrate metabolism. Conclusion: Our finding suggests that despite both groups having no difference in IR level, there are differentially expressed genes involved in the IR pathway.
{"title":"Differential Expression of Insulin Resistance Genes in Polycystic Ovary Syndrome","authors":"Fazliana Mansor, Liyana Ahmad Zamri, Hanifullah Khan","doi":"10.47836/mjmhs.19.s9.4","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.4","url":null,"abstract":"Introduction: Polycystic ovary syndrome (PCOS) is a common hormonal disorder worldwide among women of reproductive age. It is characterized by endocrine, reproductive, and metabolic abnormalities. Insulin resistance (IR) is one of its most important clinical features, which has been associated with metabolic disorders and increased risk of type 2 diabetes (T2D). This study aimed to explore the whole blood gene expression profiling related to IR in PCOS patients compared to controls. Methods: Blood RNA was extracted from 5 PCOS and 5 non-PCOS women with matched age and BMI. Homeostasis model assessment (HOMA-IR) was used to estimate the IR. The expression of IR genes was analyzed by Profiler PCR array. Results: Both groups have similar levels of HOMA-IR (p>0.05). However, differential expression levels were observed between them. Fourteen genes were upregulated and 26 genes were downregulated in PCOS samples. Among the upregulated genes (>2 fold-change, p-value<0.05) are ADIPOQ, ADIPOR1, OLR, IGF-1, and APOE. Downregulated genes (>-2 fold-change, p-value<0.05) include HK-2, IRS1, and SERPINE1. These genes are involved in insulin and adipokines signaling, commonly dysregulated in T2D. They are also involved in innate immunity and inflammatory processes and are important for lipid and carbohydrate metabolism. Conclusion: Our finding suggests that despite both groups having no difference in IR level, there are differentially expressed genes involved in the IR pathway.","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Weight is an indicator of the nutritional status of toddlers; it shows if they have poor nutrition, undernutrition, good nutrition, or overnutrition. One of the interventions carried out to solve the malnutrition problem is the provision of supplementary foods with various innovations, such as fortified biscuits with the extract of Moringa leaves (Moringa oleifera). This study aims to determine the effect of supplemental moringa biscuits on improving the nutritional status of toddler’s nutritional as seen from the increase in toddler weight. Methods: This quasi-experimental study uses a pre- and post- test design approach. The number of respondents in this study was 113 toddlers. The research was carried out in the work area of the Hinai Kiri Health Centre Integrated Service Unit, Langkat Regency, North Sumatra Province. Results: This shows that there is a significant difference in the weight of the toddler between the first measurement (before the intervention) and the second measurement (a month after the intervention). In the third measurement (2 months after the intervention) there was an increase in the average toddler’s weight, namely 1.18 kg with a p-value = 0.005 which indicated a significant difference between the toddler’s weight with the first measurement and the third measurement (2 months after the biscuit intervention). Conclusion: Moringa oleifera contains multivitamins that are effective in improving the nutritional status of malnourished toddlers. It is suggested that Moringa leaf extract can be used as a supplement to toddlers diets which can be processed according to toddlers’ tastes.
{"title":"Improvement of Toddler Weight With Giving of Moringa Leaf Extract Biscuit (Moringa oleifera)","authors":"Rinawati Sembiring, Santhana Letchmi Panduragan, Satheesh Babu Natarajan, Ruma Poddar, Agnes Purba, Henny Syapitri, Elsarika Damanik, Taruli Rohana Sinaga","doi":"10.47836/mjmhs.19.s9.21","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.21","url":null,"abstract":"Introduction: Weight is an indicator of the nutritional status of toddlers; it shows if they have poor nutrition, undernutrition, good nutrition, or overnutrition. One of the interventions carried out to solve the malnutrition problem is the provision of supplementary foods with various innovations, such as fortified biscuits with the extract of Moringa leaves (Moringa oleifera). This study aims to determine the effect of supplemental moringa biscuits on improving the nutritional status of toddler’s nutritional as seen from the increase in toddler weight. Methods: This quasi-experimental study uses a pre- and post- test design approach. The number of respondents in this study was 113 toddlers. The research was carried out in the work area of the Hinai Kiri Health Centre Integrated Service Unit, Langkat Regency, North Sumatra Province. Results: This shows that there is a significant difference in the weight of the toddler between the first measurement (before the intervention) and the second measurement (a month after the intervention). In the third measurement (2 months after the intervention) there was an increase in the average toddler’s weight, namely 1.18 kg with a p-value = 0.005 which indicated a significant difference between the toddler’s weight with the first measurement and the third measurement (2 months after the biscuit intervention). Conclusion: Moringa oleifera contains multivitamins that are effective in improving the nutritional status of malnourished toddlers. It is suggested that Moringa leaf extract can be used as a supplement to toddlers diets which can be processed according to toddlers’ tastes.","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siti Saleha Masrudin, Nur Izzah Athirah Razwan, Che Norma Mat Taib, Nurul Huda Mohd Nor, Siti Fadziyah Mohd Asri, Zazali Alias, Jamaludin Mohamad
Introduction: Benign prostatic hyperplasia (BPH) is the most prevalent prostatic disease in ageing men, characterised by an excessive proliferation of the prostatic epithelial and stromal cells. Despite the extensive choices of pharmaceutical therapies, the current treatments possess side effects, necessitating the search for new alternative options, including herbal substances such as Pueraria mirifica. This tuberous root of P. mirifica is a medicinal plant that contains numerous phytoestrogens, traditionally used for health rejuvenation in aged men and women. This study was carried out to access the inhibitory effect of 5α-reductase of P. mirifica and its histoprotective effect in a rat model of testosterone-induced BPH. Methods: Adult Sprague Dawley (12 weeks) were subcutaneously injected with testosterone propionate (3 mg/kg) daily to induce BPH. Rats (n=6) in all groups (aqueous extract of P. mirifica (APM): 10, 100, and 1000 mg/kg, p.o.; finasteride: 2mg/kg, p.o., BPH model, and sham groups) were treated for 30 days. The determination of serum dihydrotestosterone (DHT) level, prostatic index and prostate structural changes were investigated. Results: APM and finasteride-treated groups showed significantly lesser prostatic weight and prostatic index, serum DHT levels compared to the model group (p<0.05). Furthermore, there was a significantly lower prostate score with improved prostate histomorphology, demonstrating fewer epithelial involutions of glandular tissues and improved stromal and epithelial cells. Conclusion: In conclusion, the aqueous extract of P. mirifica tuberous root mitigates the development of BPH and it can be inferred that aqueous extract of P. mirifica tuberous root may possess the active agents for anti-BPH treatment.
{"title":"Inhibitory Effects of Pueraria mirifica Aqueous Extracts on 5α-reductase and Prostate Histomorphometry in Testosterone-induced Benign Prostatic Hyperplasia Sprague Dawley Rats","authors":"Siti Saleha Masrudin, Nur Izzah Athirah Razwan, Che Norma Mat Taib, Nurul Huda Mohd Nor, Siti Fadziyah Mohd Asri, Zazali Alias, Jamaludin Mohamad","doi":"10.47836/mjmhs.19.s9.32","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.32","url":null,"abstract":"Introduction: Benign prostatic hyperplasia (BPH) is the most prevalent prostatic disease in ageing men, characterised by an excessive proliferation of the prostatic epithelial and stromal cells. Despite the extensive choices of pharmaceutical therapies, the current treatments possess side effects, necessitating the search for new alternative options, including herbal substances such as Pueraria mirifica. This tuberous root of P. mirifica is a medicinal plant that contains numerous phytoestrogens, traditionally used for health rejuvenation in aged men and women. This study was carried out to access the inhibitory effect of 5α-reductase of P. mirifica and its histoprotective effect in a rat model of testosterone-induced BPH. Methods: Adult Sprague Dawley (12 weeks) were subcutaneously injected with testosterone propionate (3 mg/kg) daily to induce BPH. Rats (n=6) in all groups (aqueous extract of P. mirifica (APM): 10, 100, and 1000 mg/kg, p.o.; finasteride: 2mg/kg, p.o., BPH model, and sham groups) were treated for 30 days. The determination of serum dihydrotestosterone (DHT) level, prostatic index and prostate structural changes were investigated. Results: APM and finasteride-treated groups showed significantly lesser prostatic weight and prostatic index, serum DHT levels compared to the model group (p<0.05). Furthermore, there was a significantly lower prostate score with improved prostate histomorphology, demonstrating fewer epithelial involutions of glandular tissues and improved stromal and epithelial cells. Conclusion: In conclusion, the aqueous extract of P. mirifica tuberous root mitigates the development of BPH and it can be inferred that aqueous extract of P. mirifica tuberous root may possess the active agents for anti-BPH treatment.","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nur Hani Najwa Zainal Abidin, Nur Fatin Nabila Ramli, Nur Zakirah Zainal Abidin, Kartini Ilias, Siti Sabariah Buhari, Nur Azma Amin
Introduction: Baristas highlighted unsustainable working conditions such as wage cuts, excessive work demands, insufficient employee benefits, and lengthy workdays in the food and beverage industry. This overwhelming situation was found to have adversely affected the workers’ mental health. Objective: This research investigated mental health status and its relation to perceived workplace psychosocial factors among baristas. Methods: This cross-sectional study employed 398 baristas (response rate: 64.82.%) working in the Greater Klang Valley using the Malay version of the self-administered survey. The Depression Anxiety Stress Scale (M-DASS 21) was used to assess the participant’s mental health status while the Job Content Questionnaire (M-JCQ) evaluated the workplace psychosocial factors perceived by the participants. The socio-demographic and occupational information of the participants were also documented. The data were managed using SPSS and analyzed for descriptive and inferential analyses. Results: The results reported 195 baristas (75.60%) encountered poor mental health with the most common symptoms reported for stress (66.70%), anxiety (65.10%) and depression (49.60%). Approximately, half of the baristas experienced high job demands, low job control, and poor job support. Significant associations were recognized between depression and poor psychosocial factors (high job demands and poor job support). Conclusion: The findings indicated high prevalence of poor mental health status among baristas. Significant associations were documented between depression and workplace perceived psychosocial domains of high job demands and poor job support. This preliminary study can be used as a reference for future research in ensuring the wellness of workers in the Food and Beverage industry.
{"title":"Exploring Perceived Workplace Psychosocial Factors and Its Relation on Mental Health Among Baristas","authors":"Nur Hani Najwa Zainal Abidin, Nur Fatin Nabila Ramli, Nur Zakirah Zainal Abidin, Kartini Ilias, Siti Sabariah Buhari, Nur Azma Amin","doi":"10.47836/mjmhs.19.s9.27","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.27","url":null,"abstract":"Introduction: Baristas highlighted unsustainable working conditions such as wage cuts, excessive work demands, insufficient employee benefits, and lengthy workdays in the food and beverage industry. This overwhelming situation was found to have adversely affected the workers’ mental health. Objective: This research investigated mental health status and its relation to perceived workplace psychosocial factors among baristas. Methods: This cross-sectional study employed 398 baristas (response rate: 64.82.%) working in the Greater Klang Valley using the Malay version of the self-administered survey. The Depression Anxiety Stress Scale (M-DASS 21) was used to assess the participant’s mental health status while the Job Content Questionnaire (M-JCQ) evaluated the workplace psychosocial factors perceived by the participants. The socio-demographic and occupational information of the participants were also documented. The data were managed using SPSS and analyzed for descriptive and inferential analyses. Results: The results reported 195 baristas (75.60%) encountered poor mental health with the most common symptoms reported for stress (66.70%), anxiety (65.10%) and depression (49.60%). Approximately, half of the baristas experienced high job demands, low job control, and poor job support. Significant associations were recognized between depression and poor psychosocial factors (high job demands and poor job support). Conclusion: The findings indicated high prevalence of poor mental health status among baristas. Significant associations were documented between depression and workplace perceived psychosocial domains of high job demands and poor job support. This preliminary study can be used as a reference for future research in ensuring the wellness of workers in the Food and Beverage industry.","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: HIV/AIDS is a worldwide health problem that has claimed a total of 36.7 million lives due to the HIV virus. In Indonesia, there are 30,935 cases of HIV and 7,185 cases of AIDS. HIV/AIDS can affect a person’s mental and psychological health. For example, the most common psychological problem faced by HIV/AIDS patients is depression. Depression experienced by HIV/AIDS patients is caused by the burden of life and social stigma. To overcome the psychological problems experienced by PLHIV, it is necessary to provide psychotherapy such as Acceptance and Commitment Therapy (ACT). ACT is a form of psychotherapy that focuses on changing a person’s mindset through their experiences so that they can move on with their lives. Objective: The purpose of this study was to identify the effect of ACT on depression in PLHIV. Methods: This study used a quasi-experimental design with a one group pretest-posttest design. This study’s population consisted of all HIV/AIDS patients who were also depressed. The number of samples in this study is 33 PLWHA who had depression problems using a purposive sampling technique. The intervention given to treat depression in HIV/AIDS patients is ACT with 4 sessions, and the analysis of this study used a t-test. Results: The average depression score of respondents decreased from 38.73 before being given Acceptance and Commitment Therapy to 19.27 after being given ACT. Conclusion: There was a significant difference in the average depression score between before and after being given ACT (t= 63,162 and p=0.000).
{"title":"Depression Management Using Acceptance and Commitment Therapy Among HIV/AIDS Patients","authors":"Jek Amidos Pardede, Santhana Letchmi Panduragan, Satheesh Babu Natarajan, Galvani Volta Simanjuntak, Henny Syapitri, Marthalena Simamora, Mehru Nisha","doi":"10.47836/mjmhs.19.s9.12","DOIUrl":"https://doi.org/10.47836/mjmhs.19.s9.12","url":null,"abstract":"Introduction: HIV/AIDS is a worldwide health problem that has claimed a total of 36.7 million lives due to the HIV virus. In Indonesia, there are 30,935 cases of HIV and 7,185 cases of AIDS. HIV/AIDS can affect a person’s mental and psychological health. For example, the most common psychological problem faced by HIV/AIDS patients is depression. Depression experienced by HIV/AIDS patients is caused by the burden of life and social stigma. To overcome the psychological problems experienced by PLHIV, it is necessary to provide psychotherapy such as Acceptance and Commitment Therapy (ACT). ACT is a form of psychotherapy that focuses on changing a person’s mindset through their experiences so that they can move on with their lives. Objective: The purpose of this study was to identify the effect of ACT on depression in PLHIV. Methods: This study used a quasi-experimental design with a one group pretest-posttest design. This study’s population consisted of all HIV/AIDS patients who were also depressed. The number of samples in this study is 33 PLWHA who had depression problems using a purposive sampling technique. The intervention given to treat depression in HIV/AIDS patients is ACT with 4 sessions, and the analysis of this study used a t-test. Results: The average depression score of respondents decreased from 38.73 before being given Acceptance and Commitment Therapy to 19.27 after being given ACT. Conclusion: There was a significant difference in the average depression score between before and after being given ACT (t= 63,162 and p=0.000).","PeriodicalId":40029,"journal":{"name":"Malaysian Journal of Medicine and Health Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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