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2018 IEEE Micro Electro Mechanical Systems (MEMS)最新文献

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Multiplexed molecular biomarker analysis using an expanded library of nanoelectronically barcoded particles enabled through machine learning analysis 通过机器学习分析,使用扩展的纳米电子条形码粒子库进行多路分子生物标志物分析
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346584
Jianye Sui, Pengfei Xie, Zhongtian Lin, M. Javanmard
Electronically barcoded micro-particles have been demonstrated for use in various multiplexed molecular biomarker assays. Traditional optical and plasmonic methods for barcoding are capable of high throughput and high sensitivity, but require bulky instrumentation for readout, which cannot be easily made into a portable device. Previously, we reported a novel impedance based barcoding technique by fabricating tunable nano-capacitors on micro-particle surfaces thus modulating the overall particle impedance. In this work, we expand the library of barcoded particles using atomic layer deposited oxides of varying thickness and dielectric permittivity and study the effect of thickness and dielectric permittivity using multi-frequency impedance flow cytometry and utilize machine learning to classify different particle barcodes.
电子条形码微粒子已被证明用于各种多重分子生物标志物测定。传统的光学和等离子体条形码方法具有高通量和高灵敏度的特点,但需要笨重的读出仪器,不易制成便携式设备。在此之前,我们报道了一种新的基于阻抗的条形码技术,该技术通过在微粒子表面制造可调谐的纳米电容器来调节粒子的整体阻抗。在这项工作中,我们使用不同厚度和介电常数的原子层沉积氧化物扩展了条形码粒子库,并使用多频阻抗流式细胞术研究了厚度和介电常数的影响,并利用机器学习对不同颗粒条形码进行分类。
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引用次数: 2
An SH0 lithium niobate trans-impedance chirp compressor with high voltage gain 一种具有高电压增益的SH0型铌酸锂反阻抗啁啾压缩机
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346672
T. Manzaneque, Ruochen Lu, Yansong Yang, S. Gong
We present a new type of acoustic devices that, for the first time, can simultaneously perform chirp compression and impedance transformation to achieve passive voltage amplification with a gain of 12. The device consists of an acoustic dispersive delay line (DDL) based on shear-horizontal waves (SH0) in lithium niobate (LiNbO3). SH0 waves are employed due to their demonstrated high electromechanical coupling (k2) of 39%, low propagation loss, and a slow phase velocity of 3700 m/s. As a result of these desirable features, the fabricated device demonstrates a large fractional bandwidth (FBW) of 50%, a low insertion loss (IL), a high processing gain (TB) of 76, and a compact size of 1.57 by 0.23 mm. In addition to the compression, the device harnesses an asymmetrical transduction scheme to provide a compounding voltage gain from impedance transformation. Consequently, it results in a much higher voltage at the device output, which can be exploited to attain a higher sensitivity for wake-up radio receivers.
我们首次提出了一种新型的声学器件,它可以同时进行啁啾压缩和阻抗变换,以实现增益为12的无源电压放大。该器件由铌酸锂(LiNbO3)中基于剪切水平波(SH0)的声色散延迟线(DDL)组成。采用SH0波是因为它们具有39%的高机电耦合(k2),低传播损耗和3700 m/s的慢相速度。由于这些理想的特性,制造的器件具有50%的大分数带宽(FBW),低插入损耗(IL), 76的高处理增益(TB),以及1.57 × 0.23 mm的紧凑尺寸。除了压缩之外,该器件还利用不对称转导方案从阻抗变换中提供复合电压增益。因此,它的结果在一个高得多的电压在设备输出,这可以被利用,以获得更高的灵敏度唤醒无线电接收机。
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引用次数: 3
Selective pairing and fusion of vesicles using dielectrophoretic tweezers 用介电泳镊子对囊泡进行选择性配对和融合
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346542
S. Yoshida, S. Takeuchi
This manuscript describes selective pairing and fusion of biological vesicles using dielectrophoretic (DEP) tweezer. Fusion of biological vesicles have been widely studied for artificial cell system, however, low selectivity of fused vesicle has been problematic. We propose selective pairing and fusion of vesicles such as cell-sized liposomes and giant bacteria using microfabricated DEP tweezer. As DEP force can manipulate cell-sized (approximately 10 μm) objects, for the first time we achieved selective pairing and fusion of the vesicles and in conjunction with electrofusion device. We believe our method will be useful in vesicle fusion studies including material transport and generation of artificial cells.
本文描述了使用介电泳(DEP)镊子对生物囊泡进行选择性配对和融合。生物囊泡的融合在人工细胞系统中得到了广泛的研究,但融合囊泡的低选择性一直是一个问题。我们提出选择配对和融合囊泡,如细胞大小的脂质体和巨大的细菌使用微制造DEP镊子。由于DEP力可以操纵细胞大小(约10 μm)的物体,我们首次实现了囊泡的选择性配对和融合,并与电融合装置相结合。我们相信我们的方法将有助于囊泡融合研究,包括材料运输和人工细胞的产生。
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引用次数: 0
Waterproof pitot tube with high sensitive differential pressure sensor and nano-hole array 防水皮托管与高灵敏度差压传感器和纳米孔阵列
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346522
Hidetoshi Takahashi, I. Shimoyama
This paper reports a Pitot tube type airflow sensor, which achieves both high sensitivity and water resistance. The proposed Pitot tube is composed of piezoresistive cantilevers as differential pressure sensing elements and nano-hole arrays as waterproof elements. The nano-hole arrays are attached to the air inlets, which are located the tip of the tube and sides of the sphere. When airflow is applied to the Pitot tube, air passes through the nano-hole arrays, and differential pressure between two inlets acts on the piezoresistive cantilevers. On the other hand, when locating in water, the nano-hole arrays protect the water penetration into the tube. The Pitot tube will be used for the airspeed measurement of flying marine birds.
本文报道了一种具有高灵敏度和耐水性能的皮托管式气流传感器。所提出的皮托管由压阻悬臂梁作为差压传感元件和纳米孔阵列作为防水元件组成。纳米孔阵列附着在空气入口上,空气入口位于管的尖端和球体的两侧。当气流作用于皮托管时,空气通过纳米孔阵列,两个入口之间的压差作用于压阻悬臂梁。另一方面,当定位在水中时,纳米孔阵列保护水渗透到管中。皮托管将用于测量飞行的海鸟的空速。
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引用次数: 4
A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly 一种转移多孔PDMS膜的新方法,用于高通量芯片上器官和芯片上实验室组装
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346550
W. F. Quirós-Solano, N. Gaio, C. Silvestri, Yusuf B Arık, Oscar Stassen, A. D. V. D. Meer, C. Bouten, A. V. D. Berg, Ronald Dekker, P. M. Sarro
We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.
我们提出了一种新的方法,可以轻松可靠地在芯片实验室(LOC)和芯片器官(OOC)设备上转移高孔、大面积、薄的微加工聚二甲基硅氧烷(PDMS)多孔膜。使用硅作为载体衬底和水溶性牺牲层,可以将膜简单且可重复地转移到任何基于pdms的OOC和LOC设备。集成电路和MEMS兼容技术的使用大大减少了制造时间和人工处理的需要。我们的方法适用于自动装配系统,如拾取和放置,这对于显著提高OOC和LOC设备装配的吞吐量至关重要。孔径为8 μm、厚度为4 μm的膜成功转移。通过在带有转移的多孔PDMS膜的OOC上培养两种不同的细胞系来评估转移的活力和生物相容性。
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引用次数: 2
In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment 生物相容性掺氟类金刚石碳纳米孔膜用于血液过滤处理的体外和体内试验
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346575
T. Ota, Masamitsu Nakayama, Y. Kanno, Tetsuya Suzuki, N. Miki
In this report, we experimentally investigated the blood hemofiltration capacity of a nanoporous dialysis membrane (poly(ether sulfone), PES) whose surface was modified with fluorine-doped diamond-like carbon(f-DLC). Surface modification of the nanoporous membrane without clogging the nanopores is challenging. In vitro experiments revealed that the modified membrane successfully exhibited water permeability of one-tenth of the untreated. In vivo experiments with ultra-small hemofiltration devices composed of f-DLC PES membranes using SD rats were also conducted for the first time. The results proved that the f-DLC coated PES membrane can be used for hemofiltration, which will extend the lifetime of microfluidics-based implantable artificial kidney.
在这篇报道中,我们实验研究了纳米多孔透析膜(聚醚砜),PES)的血液过滤能力,其表面被氟掺杂类金刚石碳(f-DLC)修饰。在不堵塞纳米孔的情况下对纳米孔膜进行表面改性是一项具有挑战性的工作。体外实验表明,改性膜成功地表现出十分之一的未经处理的透水性。我们还首次在SD大鼠身上进行了由f-DLC PES膜组成的超小型血液滤过装置的体内实验。结果表明,f-DLC包覆的PES膜可用于血液过滤,延长微流控植入式人工肾的使用寿命。
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引用次数: 1
A wireless dual-mode micro thermal flow sensor system with extended flow range by using CMOS-MEMS process 基于CMOS-MEMS工艺的无线双模微热流传感器系统
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346682
Wei Xu, Beiqi Lijin, Mingzheng Duan, Xiaoyi Wang, Jeffry Wicaksana, A. Min, Moaaz Ahmed, Ruijin Wang, N. Fang, A. Bermak, Yi-Kuen Lee
In this paper, we report a wireless dual-mode micro thermal flow (DMTF) sensor system with the extended flow range by using InvenSense 0.18μm CMOS MEMS technology. For the N2 gas flow, the DMTF sensor gains a flow range of 0∼73m/s, which is 2.4 times larger than that of calorimetric flow sensor (0∼31m/s) setup. Besides, the calibrated DMTF sensor system shows an accuracy of less than 2% with the wireless monitoring capability. Therefore, this low-cost wireless DMTF sensor system will be a promising IoT (Internet of Things) device for the smart energy-efficient buildings application.
本文采用InvenSense 0.18μm CMOS MEMS技术,设计了一种扩展流量范围的无线双模微热流(DMTF)传感器系统。对于N2气体流量,DMTF传感器获得的流量范围为0 ~ 73m/s,是量热流量传感器(0 ~ 31m/s)设置的2.4倍。此外,校准后的DMTF传感器系统具有无线监测能力,精度低于2%。因此,这种低成本的无线DMTF传感器系统将成为智能节能建筑应用的一种有前途的物联网设备。
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引用次数: 18
Self-rolling up micro assembly using temperature — Responsive hydrogel sheet with rigid plate array 使用温度响应水凝胶片和刚性板阵列的自卷起微组件
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346491
Y. Iwata, S. Miyashita, E. Iwase
We propose a design method of a micro self-rolling up structure using a temperature-responsive hydrogel sheet with rigid plate array. Our self-rolling up is a method for developing a micro three-dimensional (3D) structure performed by rolling up a two-dimensional (2D) flat sheet, like making a croissant, through a continuous self-folding. The local curvature of the self-rolled up structure could be controlled by the length of rigid plates. By controlling the local curvature, we designed and developed self-rolled up structures with or without gaps between the self-rolled up layers, such as cylindrical and croissant-like ellipsoidal structures. In addition, all the structures demonstrated repetitive deformation of forward and backward rolling up by changing a temperature of water.
提出了一种基于刚性板阵列的温度响应水凝胶片的微自卷结构设计方法。我们的自卷起是一种开发微型三维(3D)结构的方法,通过卷起二维(2D)平面,就像制作羊角面包一样,通过连续的自折叠。自卷结构的局部曲率可以通过刚性板的长度来控制。通过控制局部曲率,我们设计和开发了自卷层之间有或没有间隙的自卷结构,如圆柱形和牛角面包状椭球结构。此外,所有结构都表现出通过改变水的温度而重复地向前和向后卷起的变形。
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引用次数: 0
Inline relative permittivity sensing using silicon electrodes realized in surface channel technology 采用表面通道技术实现了硅电极的在线相对介电常数传感
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346686
D. Alveringh, R. Wiegerink, J. C. Lotters
Sensing relative permittivity is useful for fluid characterization, since its value differs significantly for different substances. A microfabricated inline relative permittivity sensor is realized using surface channel technology with support for isolated silicon electrodes. This enables non-invasive composition measurements of chemicals, i.e. the chemicals are not in contact with an electrode, do not need to be heated or need to be mixed with a chemical marker. Since this sensor operates inline, real-time measurements of the fluid can be obtained. Besides, integration with other fluid sensors, e.g. flow or pressure sensors, on a single chip could be achieved due to the sensor's full compatibility with surface channel technology. This is the first device that successfully uses the isolated silicon electrode functionality of this fabrication technology. Preliminary measurement results show a high coefficient of determination (R2 = 99.83 %) with the model.
感应相对介电常数对流体表征是有用的,因为它的值对不同的物质有很大的不同。采用表面通道技术,在隔离硅电极的支撑下,实现了一种微结构内联相对介电常数传感器。这使得化学物质的非侵入性成分测量成为可能,即化学物质不与电极接触,不需要加热或需要与化学标记物混合。由于该传感器在线工作,因此可以获得流体的实时测量。此外,由于该传感器与表面通道技术完全兼容,因此可以与其他流体传感器(例如流量或压力传感器)集成在单个芯片上。这是第一个成功使用这种制造技术的隔离硅电极功能的设备。初步测定结果表明,该模型具有较高的决定系数(R2 = 99.83%)。
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引用次数: 3
Location-specific fabrication of suspended metal nanowire based on electrospun nanofibers on MEMS platform MEMS平台上基于静电纺纳米纤维的悬浮金属纳米线的定位制备
Pub Date : 2018-04-24 DOI: 10.1109/MEMSYS.2018.8346597
Yongkeun Oh, D. Kwon, Wondo Kim, Jongbaeg Kim
In this paper, we propose a location-specific batch fabrication process to form suspended metal nanowire between two microelectrodes. This simple and low temperature fabrication method consists of 3 steps; electrospinning polymer nanofibers on MEMS platform with micro gap, metal evaporation, and dissolving polymer nanofibers in liquid and drying. Here we demonstrate the proposed process with Pd to form suspended Pd nanowire, for the possible future application as hydrogen sensor. The surface tension force during the drying enables the formation of single wire from multiple wires. The proposed method allows diverse choice of nanowire material and thus can find various applications of two-terminal nanowire devices.
在本文中,我们提出了一种特定位置的批量制造工艺,在两个微电极之间形成悬浮金属纳米线。这种简单的低温制作方法包括3个步骤;基于微间隙MEMS平台的静电纺丝聚合物纳米纤维,金属蒸发,聚合物纳米纤维在液体中溶解和干燥。在这里,我们展示了用钯形成悬浮钯纳米线的工艺,为未来可能的氢传感器应用提供了可能。干燥过程中的表面张力使多条线形成单线。该方法允许多种纳米线材料的选择,从而可以找到双端纳米线器件的各种应用。
{"title":"Location-specific fabrication of suspended metal nanowire based on electrospun nanofibers on MEMS platform","authors":"Yongkeun Oh, D. Kwon, Wondo Kim, Jongbaeg Kim","doi":"10.1109/MEMSYS.2018.8346597","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346597","url":null,"abstract":"In this paper, we propose a location-specific batch fabrication process to form suspended metal nanowire between two microelectrodes. This simple and low temperature fabrication method consists of 3 steps; electrospinning polymer nanofibers on MEMS platform with micro gap, metal evaporation, and dissolving polymer nanofibers in liquid and drying. Here we demonstrate the proposed process with Pd to form suspended Pd nanowire, for the possible future application as hydrogen sensor. The surface tension force during the drying enables the formation of single wire from multiple wires. The proposed method allows diverse choice of nanowire material and thus can find various applications of two-terminal nanowire devices.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129594744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
2018 IEEE Micro Electro Mechanical Systems (MEMS)
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